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Randal Kaufman

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Stewart Siyan Cao; Brandy-Mengchieh Chuang; Kathryn A Eaton; Anosike Nwokoye; Benbo Song; J Erby Wilkinson; Ellen M Zimmermann; Randal J Kaufman
The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.
J Han; H Malhi; R Murthy; Benbo Song; B Sun; S Wang; B Wood; Randal J Kaufman
ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Justin Hassler; Stewart S Cao; Randal J Kaufman
IRE1, a double-edged sword in pre-miRNA slicing and cell death.

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All Publications

2013: Stewart Siyan Cao; Brandy-Mengchieh Chuang; Kathryn A Eaton; Anosike Nwokoye; Benbo Song; J Erby Wilkinson; Ellen M Zimmermann; Randal J Kaufman
The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.
Gastroenterology 2013;144(5):989-1000.e6.
2013: J Han; H Malhi; R Murthy; Benbo Song; B Sun; S Wang; B Wood; Randal J Kaufman
ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Diabetologia 2013;56(4):911-24.
2012: Justin Hassler; Stewart S Cao; Randal J Kaufman
IRE1, a double-edged sword in pre-miRNA slicing and cell death.
Developmental cell 2012;23(5):921-3.
2012: Shiyu Wang; Vivian Lam; Zhouji Chen; Nicholas O Davidson; Brian N Finck; Jaeseok Han; Justin Hassler; Randal J Kaufman
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.
Cell metabolism 2012;16(4):473-86.
2012: Stewart Siyan Cao; Benbo Song; Randal J Kaufman
PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling.
Inflammatory bowel diseases 2012;18(9):1735-42.
2012: Stewart Siyan Cao; Randal J Kaufman
Unfolded protein response.
Current biology : CB 2012;22(16):R622-6.
2012: Kenjiro Sakaki; Xiaohua Shen; Mon Xiong; Sawako Yoshina; Melinda R DeSantis; Jaeseok Han; Shohei Mitani; Randal J Kaufman
RNA surveillance is required for endoplasmic reticulum homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(21):8079-84.
2012: Chunbin Zhang; Xuebao Zhang; Ze Zheng; Stephen A Duncan; Gregory Dyson; Randal J Kaufman; Krishna Rao Maddipati; Guohui Wang; Paul Williams; Kezhong Zhang
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice.
Hepatology (Baltimore, Md.) 2012;55(4):1070-82.
2012: Jeffrey G Dickhout; Sanjay Garg; Danielle E Jerome; Hua Jiang; Randal J Kaufman; Kenneth N Maclean; Sarathi Mani; Zahraa Mohammed-Ali; Rui Wang; Guangdong Yang; Ruma Banerjee; Rachel E Carlisle; Richard C Austin
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.
The Journal of biological chemistry 2012;287(10):7603-14.
2012: S R Selvaraj; A N Scheller; Randal J Kaufman; H Z Miao; Steven W Pipe
Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop.
Journal of thrombosis and haemostasis : JTH 2012;10(1):107-15.
2011: Bin Zhang; Chunlei zheng; Min Zhu; Andrea Baines; Randal J Kaufman; Jinoh Kim; Randy Schekman; Jiayi Tao; Matthew P Vasievich; David Ginsburg
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Blood 2011;118(12):3384-91.
2011: Jyoti D Malhotra; Randal J Kaufman
ER stress and its functional link to mitochondria: role in cell survival and death.
Cold Spring Harbor perspectives in biology 2011;3(9):a004424.
2011: Ningguo Gao; Heather P Harding; Dang Huynh; Randal J Kaufman; Vijaya L Manthati; Ian Mohr; David Ron; Jie Shang; Carolina Arias; John R Falck; Mark A Lehrman
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.
Molecular biology of the cell 2011;22(17):2994-3009.
2011: Stewart Siyan Cao; Randal J Kaufman
iRhoms: ERADicating the messenger in growth control signaling.
Developmental cell 2011;20(4):414-6.
2011: Kezhong Zhang; Shiyu Wang; Jyoti D Malhotra; Justin R Hassler; Sung Hoon Back; Guohui Wang; Lin Chang; Wenbo Xu; Hongzhi Miao; Roberta Leonardi; Y Eugene Chen; Suzanne Jackowski; Randal J Kaufman
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.
The EMBO journal 2011;30(7):1357-75.
2011: Harmeet Malhi; Randal J Kaufman
Endoplasmic reticulum stress in liver disease.
Journal of hepatology 2011;54(4):795-809.
2011: Jun Wu; Jorge L Ruas; Jennifer L Estall; Kyle A Rasbach; Jang Hyun Choi; Li Ye; Pontus Boström; Heather M Tyra; Robert W Crawford; Kevin P Campbell; D Thomas Rutkowski; Randal J Kaufman; Bruce M Spiegelman
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.
Cell metabolism 2011;13(2):160-9.
2011: Andrew M Fribley; Justin R Miller; Tyler E Reist; Michael U Callaghan; Randal J Kaufman
Large-scale analysis of UPR-mediated apoptosis in human cells.
Methods in enzymology 2011;491():57-71.
2010: Randal J Kaufman; Sung Hoon Back; Benbo Song; J Han; J Hassler
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells.
Diabetes, obesity & metabolism 2010;12 Suppl 2():99-107.
2010: Hala Muaddi; Mithu Majumder; Philippos Peidis; Andreas I Papadakis; Martin Holcik; Donalyn Scheuner; Randal J Kaufman; Maria Hatzoglou; Antonis E Koromilas
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
Molecular biology of the cell 2010;21(18):3220-31.
2010: Juthakorn Poothong; Pattarawut Sopha; Randal J Kaufman; Witoon Tirasophon
Domain compatibility in Ire1 kinase is critical for the unfolded protein response.
FEBS letters 2010;584(14):3203-8.
2010: Charlie C Huang; Yi Li; Alex B Lopez; Cheng-Ming Chiang; Randal J Kaufman; Martin D Snider; Maria Hatzoglou
Temporal regulation of Cat-1 (cationic amino acid transporter-1) gene transcription during endoplasmic reticulum stress.
The Biochemical journal 2010;429(1):215-24.
2010: Randal J Kaufman; Siyan Cao
Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism.
EMBO molecular medicine 2010;2(6):189-92.
2010: Bradley R Pearse; Taku Tamura; Johan C Sunryd; Gregory A Grabowski; Randal J Kaufman; Daniel N Hebert
The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin.
The Journal of cell biology 2010;189(5):829-41.
2010: Elena Bevilacqua; Xinglong Wang; Mithu Majumder; Francesca Gaccioli; Celvie L Yuan; Chuanping Wang; Xiongwei Zhu; Lindsay E Jordan; Donalyn Scheuner; Randal J Kaufman; Antonis E Koromilas; Martin D Snider; Martin Holcik; Maria Hatzoglou
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.
The Journal of biological chemistry 2010;285(22):17098-111.
2010: Oliver Schulz; Andreas Pichlmair; Jan Rehwinkel; Neil C Rogers; Donalyn Scheuner; Hiroki Kato; Osamu Takeuchi; Shizuo Akira; Randal J Kaufman; Caetano Reis e Sousa
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.
Cell host & microbe 2010;7(5):354-61.
2010: Radiah A Corn Minor; Gino V Limmon; Laura Miller-DeGraff; Darlene Dixon; Danica M K Andrews; Randal J Kaufman; Farhad Imani
Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(4):263-72.
2010: Yifu Qiu; Ting Mao; Yongliang Zhang; Mengle Shao; Jia You; Qiurong Ding; Yan Chen; Dongmei Wu; Dong Xie; Xu Lin; Xiang Gao; Randal J Kaufman; Wenjun Li; Yong Liu
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.
Science signaling 2010;3(106):ra7.
2009: Chiara Vecchi; Giuliana Montosi; Kezhong Zhang; Igor Lamberti; Stephen A Duncan; Randal J Kaufman; Antonello Pietrangelo
ER stress controls iron metabolism through induction of hepcidin.
Science (New York, N.Y.) 2009;325(5942):877-80.
2009: Jenny B DuRose; Donalyn Scheuner; Randal J Kaufman; Lawrence I Rothblum; Maho Niwa
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.
Molecular and cellular biology 2009;29(15):4295-307.
2009: Mark J Davies; Elena Miranda; Benoit D Roussel; Randal J Kaufman; Stefan Marciniak; David A Lomas
Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.
The Journal of biological chemistry 2009;284(27):18202-9.
2009: Sung Hoon Back; Donalyn Scheuner; Jaeseok Han; Benbo Song; Mark Ribick; Junying Wang; Robert D Gildersleeve; Subramaniam Pennathur; Randal J Kaufman
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
Cell metabolism 2009;10(1):13-26.
2009: Sophie Mokas; John R Mills; Cristina Garreau; Marie-Josée Fournier; Francis Robert; Prabhat Arya; Randal J Kaufman; Jerry Pelletier; Rachid Mazroui
Uncoupling stress granule assembly and translation initiation inhibition.
Molecular biology of the cell 2009;20(11):2673-83.
2009: Hemamalini Bommiasamy; Sung Hoon Back; Paolo Fagone; Kyungho Lee; Sasha Meshinchi; Elizabeth Vink; Rungtawan Sriburi; Matthew Frank; Suzanne Jackowski; Randal J Kaufman; Joseph W Brewer
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.
Journal of cell science 2009;122(Pt 10):1626-36.
2009: Heather P Harding; Yuhong Zhang; Donalyn Scheuner; Jane-Jane Chen; Randal J Kaufman; David Ron
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1832-7.
2009: Jiou Wang; George W Farr; Caroline J Zeiss; Diego Rodríguez Gil; Jean H Wilson; Krystyna J Furtak; D Thomas Rutkowski; Randal J Kaufman; Cristian I Ruse; John R Yates; Steve Perrin; Mel B Feany; Arthur L Horwich
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1392-7.
2009: Zineb Mounir; Jothi Latha Krishnamoorthy; Gavin P Robertson; Donalyn Scheuner; Randal J Kaufman; Maria-Magdalena Georgescu; Antonis E Koromilas
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Science signaling 2009;2(102):ra85.
2009: Andrew Fribley; Kezhong Zhang; Randal J Kaufman
Regulation of apoptosis by the unfolded protein response.
Methods in molecular biology (Clifton, N.J.) 2009;559():191-204.
2008: D Thomas Rutkowski; Jun Wu; Sung-Hoon Back; Michael U Callaghan; Sean P Ferris; Jahangir Iqbal; Robert Clark; Hongzhi Miao; Justin R Hassler; Jamie Fornek; Michael G Katze; M Mahmood Hussain; Benbo Song; Jayanth Swathirajan; Junying Wang; Grace D-Y Yau; Randal J Kaufman
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
Developmental cell 2008;15(6):829-40.
2008: Jyoti D Malhotra; Hongzhi Miao; Kezhong Zhang; Anna Wolfson; Subramaniam Pennathur; Steven W Pipe; Randal J Kaufman
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18525-30.
2008: Jinhwan Kim; Tae Gyu Choi; Yan Ding; Yeonghwan Kim; Kwon-Soo Ha; Kyung Ho Lee; Insug Kang; Joohun Ha; Randal J Kaufman; Jinhwa Lee; Wonchae Choe; Sung Soo Kim
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress.
Journal of cell science 2008;121(Pt 21):3636-48.
2008: Frank C Brosius III; Randal J Kaufman
Is the ER stressed out in diabetic kidney disease?
Journal of the American Society of Nephrology : JASN 2008;19(11):2040-2.
2008: Benbo Song; Donalyn Scheuner; David Ron; Subramaniam Pennathur; Randal J Kaufman
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
The Journal of clinical investigation 2008;118(10):3378-89.
2008: Jennifer Luebke-Wheeler; Kezhong Zhang; Michele Battle; Karim Si-Tayeb; Wendy D Garrison; Sodhi Chhinder; Jixuan Li; Randal J Kaufman; Stephen A Duncan
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H.
Hepatology (Baltimore, Md.) 2008;48(4):1242-50.
2008: Keisuke Yamamoto; Natsumi Suzuki; Tadashi Wada; Tetsuya Okada; Hiderou Yoshida; Randal J Kaufman; Kazutoshi Mori
Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.
Journal of biochemistry 2008;144(4):477-86.
2008: Baldwin C Mak; Qin Wang; Carol A Laschinger; Wilson Lee; David Ron; Heather P Harding; Randal J Kaufman; Donalyn Scheuner; Richard C Austin; Christopher A McCulloch
Novel function of PERK as a mediator of force-induced apoptosis.
The Journal of biological chemistry 2008;283(34):23462-72.
2008: Hesso Farhan; Matthias Weiss; Katsuko Tani; Randal J Kaufman; Hans-Peter Hauri
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load.
The EMBO journal 2008;27(15):2043-54.
2008: Kenjiro Sakaki; Randal J Kaufman
Regulation of ER stress-induced macroautophagy by protein kinase C.
Autophagy 2008;4(6):841-3.
2008: Kezhong Zhang; Randal J Kaufman
From endoplasmic-reticulum stress to the inflammatory response.
Nature 2008;454(7203):455-62.
2008: Bin Zhang; Marta Spreafico; Chunlei zheng; Angela Yang; Petra Platzer; Michael U Callaghan; Zekai Avci; Namik Ozbek; Johnny Mahlangu; Tabitha Haw; Randal J Kaufman; Kandice Marchant; Edward G D Tuddenham; Uri Seligsohn; Flora Peyvandi; David Ginsburg
Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.
Blood 2008;111(12):5592-600.
2008: Kenjiro Sakaki; Jun Wu; Randal J Kaufman
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum.
The Journal of biological chemistry 2008;283(22):15370-80.
2008: Donalyn Scheuner; Randal J Kaufman
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.
Endocrine reviews 2008;29(3):317-33.
2008: Michelle M Thiaville; Yuan-Xiang Pan; Altin Gjymishka; Can Zhong; Randal J Kaufman; Michael S Kilberg
MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.
The Journal of biological chemistry 2008;283(16):10848-57.
2008: Vladimir V Zeenko; Chuanping Wang; Mithu Majumder; Anton A Komar; Martin D Snider; William C Merrick; Randal J Kaufman; Maria Hatzoglou
An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation.
RNA (New York, N.Y.) 2008;14(3):593-602.
2008: Kezhong Zhang; Randal J Kaufman
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo.
Methods in enzymology 2008;442():395-419.
2007: Jyoti D Malhotra; Randal J Kaufman
The endoplasmic reticulum and the unfolded protein response.
Seminars in cell & developmental biology 2007;18(6):716-31.
2007: Jyoti D Malhotra; Randal J Kaufman
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
Antioxidants & redox signaling 2007;9(12):2277-93.
2007: Vincenzo Cerullo; Michael Seiler; Viraj Mane; Racel Cela; Christian Clarke; Randal J Kaufman; Steven W Pipe; Brendan Lee
Correction of murine hemophilia A and immunological differences of factor VIII variants delivered by helper-dependent adenoviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2080-7.
2007: D Thomas Rutkowski; Randal J Kaufman
That which does not kill me makes me stronger: adapting to chronic ER stress.
Trends in biochemical sciences 2007;32(10):469-76.
2007: Jun Wu; D Thomas Rutkowski; Meghan Dubois; Jayanth Swathirajan; Thomas L Saunders; Junying Wang; Benbo Song; Grace D-Y Yau; Randal J Kaufman
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.
Developmental cell 2007;13(3):351-64.
2007: D Thomas Rutkowski; Sang-Wook Kang; Alan G Goodman; Jennifer L Garrison; Jack Taunton; Michael G Katze; Randal J Kaufman; Ramanujan S Hegde
The role of p58IPK in protecting the stressed endoplasmic reticulum.
Molecular biology of the cell 2007;18(9):3681-91.
2007: Maurizio Renna; Maria Gabriella Caporaso; Stefano Bonatti; Randal J Kaufman; Paolo Remondelli
Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress.
The Journal of biological chemistry 2007;282(31):22499-512.
2007: Tatiana Soldà; Carmela Galli; Randal J Kaufman; Maurizio Molinari
Substrate-specific requirements for UGT1-dependent release from calnexin.
Molecular cell 2007;27(2):238-49.
2007: Benjamin Drogat; Patrick Auguste; Duc Thang Nguyên; Marion Bouchecareilh; Raphael Pineau; Josephine Nalbantoglu; Randal J Kaufman; Eric Chevet; Andreas Bikfalvi; Michel Moenner
IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.
Cancer research 2007;67(14):6700-7.
2007: Rachid Mazroui; Sergio Di Marco; Randal J Kaufman; Imed-Eddine Gallouzi
Inhibition of the ubiquitin-proteasome system induces stress granule formation.
Molecular biology of the cell 2007;18(7):2603-18.
2007: Aihua Zhu; Hongmin Sun; Richard M Raymond; Barbara C Furie; Bruce Furie; Mila Bronstein; Randal J Kaufman; Randal J Westrick; David Ginsburg
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
Blood 2007;109(12):5270-5.
2007: Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Randal J Kaufman; Kazuhiro Nagata
Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.
EMBO reports 2007;8(5):483-9.
2007: Mauro Costa-Mattioli; Delphine Gobert; Elad Stern; Karine Gamache; Rodney Colina; Claudio Cuello; Wayne S Sossin; Randal J Kaufman; Jerry Pelletier; Kobi Rosenblum; Kresimir Krnjević; Jean-Claude Lacaille; Karim Nader; Nahum Sonenberg
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Cell 2007;129(1):195-206.
2007: Jie Shang; Ningguo Gao; Randal J Kaufman; David Ron; Heather P Harding; Mark A Lehrman
Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux.
The Journal of cell biology 2007;176(5):605-16.
2007: Dirk Vander Mierde; Donalyn Scheuner; Roel Quintens; Rupali Patel; Benbo Song; Katsura Tsukamoto; Monique Beullens; Randal J Kaufman; Mathieu Bollen; Frans Schuit
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.
Endocrinology 2007;148(2):609-17.
2007: Yoriko Kouroku; Eriko Fujita; Isei Tanida; T Ueno; Atsushi Isoai; Hiromichi Kumagai; S Ogawa; Randal J Kaufman; E Kominami; Takashi Momoi
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
Cell death and differentiation 2007;14(2):230-9.
2006: D Thomas Rutkowski; Stacey Marie Arnold; Corey N Miller; Jun Wu; Jack Li; Kathryn M Gunnison; Kazutoshi Mori; Amir A Sadighi Akha; David Raden; Randal J Kaufman
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.
PLoS biology 2006;4(11):e374.
2006: Beat Nyfeler; Bin Zhang; David Ginsburg; Randal J Kaufman; Hans-Peter Hauri
Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.
Traffic (Copenhagen, Denmark) 2006;7(11):1473-81.
2006: Francis Robert; Lee Kapp; Shakila N Khan; Michael Acker; Sarah E Kolitz; Shirin Kazemi; Randal J Kaufman; William C Merrick; Antonis E Koromilas; Jon R Lorsch; Jerry Pelletier
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability.
Molecular biology of the cell 2006;17(11):4632-44.
2006: Yongjun Dang; Nancy Kedersha; Woon-Kai Low; Daniel Romo; Myriam Gorospe; Randal J Kaufman; Paul Anderson; Jun O Liu
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.
The Journal of biological chemistry 2006;281(43):32870-8.
2006: Andrew Fribley; Benjamin Evenchik; Qinghua Zeng; Bae-Keun Park; Jean Y Guan; Honglai Zhang; Timothy J Hale; Maria S Soengas; Randal J Kaufman; Cun-Yu Wang
Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.
The Journal of biological chemistry 2006;281(42):31440-7.
2006: Christophe Denoyelle; George A Abou-Rjaily; Vladimir Bezrookove; Monique Verhaegen; Timothy M Johnson; Douglas R Fullen; Jenny N Pointer; Stephen B Gruber; Lyndon D Su; Mikhail Nikiforov; Randal J Kaufman; Boris C Bastian; Maria S Soengas
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.
Nature cell biology 2006;8(10):1053-63.
2006: Rachid Mazroui; Rami Sukarieh; Marie-Eve Bordeleau; Randal J Kaufman; Peter T Northcote; Junichi Tanaka; Imed-Eddine Gallouzi; Jerry Pelletier
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.
Molecular biology of the cell 2006;17(10):4212-9.
2006: Jiahai Zhou; Chuan Yin Liu; Sung Hoon Back; Robert L Clark; Daniel Peisach; Zhaohui Xu; Randal J Kaufman
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14343-8.
2006: Donalyn Scheuner; Rupali Patel; Feng Wang; Kuei Lee; Kotlo Kumar; Jun Wu; Anders Nilsson; Michael Karin; Randal J Kaufman
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
The Journal of biological chemistry 2006;281(30):21458-68.
2006: Sung Hoon Back; Kyungho Lee; Elizabeth Vink; Randal J Kaufman
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.
The Journal of biological chemistry 2006;281(27):18691-706.
2006: Flora Peyvandi; Randal J Kaufman; U Seligsohn; O Salomon; Paula H B Bolton-Maggs; Marta Spreafico; Marzia Menegatti; Roberta Palla; Simona Maria Siboni; Pier M Mannucci
Rare bleeding disorders.
Haemophilia : the official journal of the World Federation of Hemophilia 2006;12 Suppl 3():137-42.
2006: Ping Hu; Zhang Han; Anthony D Couvillon; Randal J Kaufman; John H Exton
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression.
Molecular and cellular biology 2006;26(8):3071-84.
2006: Marianne Koritzinsky; Michaël G Magagnin; Twan van den Beucken; Renaud Seigneuric; Kim Savelkouls; Josée Dostie; Stéphane Pyronnet; Randal J Kaufman; Sherry A Weppler; Jan Willem Voncken; Philippe Lambin; Constantinos Koumenis; Nahum Sonenberg; Bradly G Wouters
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.
The EMBO journal 2006;25(5):1114-25.
2006: J Wu; Randal J Kaufman
From acute ER stress to physiological roles of the Unfolded Protein Response.
Cell death and differentiation 2006;13(3):374-84.
2006: Bin Zhang; Beth McGee; Jennifer S Yamaoka; Hugo Guglielmone; Katharine A Downes; Salvador Minoldo; Gustavo Jarchum; Flora Peyvandi; Norma de Bosch; Arlette Ruiz-Saez; Bernard Chatelain; Marian Olpinski; Paula L Bockenstedt; Wolfgang Sperl; Randal J Kaufman; William C Nichols; Edward G D Tuddenham; David Ginsburg
Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.
Blood 2006;107(5):1903-7.
2006: Kezhong Zhang; Xiaohua Shen; Jun Wu; Kenjiro Sakaki; Thomas L Saunders; D Thomas Rutkowski; Sung Hoon Back; Randal J Kaufman
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.
Cell 2006;124(3):587-99.
2006: Martin Schröder; Randal J Kaufman
Divergent roles of IRE1alpha and PERK in the unfolded protein response.
Current molecular medicine 2006;6(1):5-36.
2006: Jennifer A Smith; Stephen C Schmechel; Arvind Raghavan; Michelle L Abelson; Cavan Reilly; Michael G Katze; Randal J Kaufman; Paul R Bohjanen; Leslie A Schiff
Reovirus induces and benefits from an integrated cellular stress response.
Journal of virology 2006;80(4):2019-33.
2006: Yukako Oda; Tetsuya Okada; Hiderou Yoshida; Randal J Kaufman; Kazuhiro Nagata; Kazutoshi Mori
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.
The Journal of cell biology 2006;172(3):383-93.
2006: Kezhong Zhang; Randal J Kaufman
The unfolded protein response: a stress signaling pathway critical for health and disease.
Neurology 2006;66(2 Suppl 1):S102-9.
2006: Kezhong Zhang; Randal J Kaufman
Protein folding in the endoplasmic reticulum and the unfolded protein response.
Handbook of experimental pharmacology 2006;(172):69-91.
2005: Heather P Harding; Yuhong Zhang; Sonya Khersonsky; Stefan Marciniak; Donalyn Scheuner; Randal J Kaufman; Norman B Javitt; Young-Tae Chang; David Ron
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.
Cell metabolism 2005;2(6):361-71.
2005: Maurizio Molinari; Carmela Galli; Omar Vanoni; Stacey Marie Arnold; Randal J Kaufman
Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence.
Molecular cell 2005;20(4):503-12.
2005: Meixia Bi; Christine Naczki; Marianne Koritzinsky; Diane R Fels; Jaime Blais; Nianping Hu; Heather P Harding; Isabel Novoa; Mahesh Varia; James Raleigh; Donalyn Scheuner; Randal J Kaufman; John Bell; David Ron; Bradly G Wouters; Constantinos Koumenis
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.
The EMBO journal 2005;24(19):3470-81.
2005: Xiaohua Shen; Ronald E. Ellis; Kenjiro Sakaki; Randal J Kaufman
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
PLoS genetics 2005;1(3):e37.
2005: Gerald McInerney; Nancy Kedersha; Randal J Kaufman; Paul Anderson; Peter Liljeström
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation.
Molecular biology of the cell 2005;16(8):3753-63.
2005: Bin Zhang; Randal J Kaufman; David Ginsburg
LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway.
The Journal of biological chemistry 2005;280(27):25881-6.
2005: Donalyn Scheuner; Dirk Vander Mierde; Benbo Song; Daisy Flamez; John W M Creemers; Katsura Tsukamoto; Mark Ribick; Frans Schuit; Randal J Kaufman
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.
Nature medicine 2005;11(7):757-64.
2005: Nancy Kedersha; Georg Stoecklin; Maranatha Ayodele; Patrick Yacono; Jens Lykke-Andersen; Marvin Fritzler; Donalyn Scheuner; Randal J Kaufman; David E Golan; Paul Anderson
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.
The Journal of cell biology 2005;169(6):871-84.
2005: Edward McEwen; Nancy Kedersha; Benbo Song; Donalyn Scheuner; Natalie Gilks; Anping Han; Jane-Jane Chen; Paul Anderson; Randal J Kaufman
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.
The Journal of biological chemistry 2005;280(17):16925-33.
2005: Sung Hoon Back; Martin Schröder; Kyungho Lee; Kezhong Zhang; Randal J Kaufman
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1.
Methods (San Diego, Calif.) 2005;35(4):395-416.
2005: Michael Boyce; Kevin F Bryant; Céline Jousse; Kai Long; Heather P Harding; Donalyn Scheuner; Randal J Kaufman; Dawei Ma; Donald M Coen; David Ron; Junying Yuan
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 2005;307(5711):935-9.
2005: James Fernandez; Ibrahim Yaman; Charles Huang; Haiyan Liu; Alex B Lopez; Anton A Komar; Mark G Caprara; William C Merrick; Martin D Snider; Randal J Kaufman; Wouter H Lamers; Maria Hatzoglou
Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.
Molecular cell 2005;17(3):405-16.
2005: Kezhong Zhang; Hetty N Wong; Benbo Song; Corey N Miller; Donalyn Scheuner; Randal J Kaufman
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
The Journal of clinical investigation 2005;115(2):268-81.
2005: Martin Schröder; Randal J Kaufman
ER stress and the unfolded protein response.
Mutation research 2005;569(1-2):29-63.
2005: Martin Schröder; Randal J Kaufman
The mammalian unfolded protein response.
Annual review of biochemistry 2005;74():739-89.
2004: Jing Deng; Phoebe D Lu; Yuhong Zhang; Donalyn Scheuner; Randal J Kaufman; Nahum Sonenberg; Heather P Harding; David Ron
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.
Molecular and cellular biology 2004;24(23):10161-8.
2004: Keisuke Yamamoto; Hiderou Yoshida; Koichi Kokame; Randal J Kaufman; Kazutoshi Mori
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II.
Journal of biochemistry 2004;136(3):343-50.
2004: Xiaohua Shen; Kezhong Zhang; Randal J Kaufman
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum.
Journal of chemical neuroanatomy 2004;28(1-2):79-92.
2004: Duc Thang Nguyên; Sem Kebache; Ali Fazel; Hetty N Wong; Sarah Jenna; Anouk Emadali; Eun-Hye Lee; John J M Bergeron; Randal J Kaufman; Louise Larose; Eric Chevet
Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress.
Molecular biology of the cell 2004;15(9):4248-60.
2004: Shiyong Wu; Randal J Kaufman
trans-Autophosphorylation by the isolated kinase domain is not sufficient for dimerization or activation of the dsRNA-activated protein kinase PKR.
Biochemistry 2004;43(34):11027-34.
2004: Shiyong Wu; Mingjia Tan; Yuanyuan Hu; Ju-Lin Wang; Donalyn Scheuner; Randal J Kaufman
Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis.
The Journal of biological chemistry 2004;279(33):34898-902.
2004: Peiqing Ye; Arthur R Thompson; Rita Sarkar; Zhenping Shen; David P Lillicrap; Randal J Kaufman; Hans D Ochs; David J Rawlings; Carol H Miao
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(1):117-26.
2004: Kezhong Zhang; Randal J Kaufman
Signaling the unfolded protein response from the endoplasmic reticulum.
The Journal of biological chemistry 2004;279(25):25935-8.
2004: Martin Schröder; Robert Clark; Chuan Yin Liu; Randal J Kaufman
The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase.
The EMBO journal 2004;23(11):2281-92.
2004: Hongzhi Z Miao; Nongnuch Sirachainan; Lisa Palmer; Phillip Kucab; Michael A Cunningham; Randal J Kaufman; Steven W Pipe
Bioengineering of coagulation factor VIII for improved secretion.
Blood 2004;103(9):3412-9.
2004: Keith D Tardif; Kazutoshi Mori; Randal J Kaufman; Aleem Siddiqui
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.
The Journal of biological chemistry 2004;279(17):17158-64.
2004: Li-Chung Hsu; Jin Mo Park; Kezhong Zhang; Jun-Li Luo; Shin Maeda; Randal J Kaufman; Lars Eckmann; Donald G Guiney; Michael Karin
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.
Nature 2004;428(6980):341-5.
2004: Randal J Kaufman
Regulation of mRNA translation by protein folding in the endoplasmic reticulum.
Trends in biochemical sciences 2004;29(3):152-8.
2004: Phoebe D Lu; Céline Jousse; Stefan Marciniak; Yuhong Zhang; Isabel Novoa; Donalyn Scheuner; Randal J Kaufman; David Ron; Heather P Harding
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.
The EMBO journal 2004;23(1):169-79.
2004: D Thomas Rutkowski; Randal J Kaufman
A trip to the ER: coping with stress.
Trends in cell biology 2004;14(1):20-8.
2004: C Wiederkehr; R Basavaraj; C Sarrauste de Menthière; L Hermida; R Koch; U Schlecht; A Amon; S Brachat; M Breitenbach; P Briza; S Caburet; M Cherry; R Davis; A Deutschbauer; H G Dickinson; T Dumitrescu; M Fellous; A Goldman; J A Grootegoed; R Scott Hawley; Ryohei Ishii; B Jégou; Randal J Kaufman; F Klein; N Lamb; B Maro; K Nasmyth; A Nicolas; Terry L. Orr-Weaver; P Philippsen; C Pineau; K P Rabitsch; V Reinke; H Roest; W Saunders; M Schröder; T Schedl; M Siep; A Villeneuve; D J Wolgemuth; M Yamamoto; D Zickler; R E Esposito; Michael Primig
GermOnline, a cross-species community knowledgebase on germ cell differentiation.
Nucleic acids research 2004;32(Database issue):D560-7.
2003: Gunda Aparna; Abani K Bhuyan; Sudhir Sahdev; Seyed E Hasnain; Randal J Kaufman; Kolluru V A Ramaiah
Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation.
Biochemistry 2003;42(51):15352-60.
2003: Donalyn Scheuner; Matthias Gromeier; Monique V Davies; Andrew J Dorner; Benbo Song; Rupali V Patel; Eckard J Wimmer; Roger E McLendon; Randal J Kaufman
The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.
Virology 2003;317(2):263-74.
2003: Randal J Kaufman
Good things come in small packages for hemophilia.
Journal of thrombosis and haemostasis : JTH 2003;1(12):2472-3.
2003: Michael A Cunningham; Steven W Pipe; Bin Zhang; Hans-Peter Hauri; David Ginsburg; Randal J Kaufman
LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII.
Journal of thrombosis and haemostasis : JTH 2003;1(11):2360-7.
2003: Stacey Marie Arnold; Randal J Kaufman
The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.
The Journal of biological chemistry 2003;278(44):43320-8.
2003: Sara B. Cullinan Gladden; Donna D Zhang; Mark Hannink; Edward Arvisais; Randal J Kaufman; J Alan Diehl
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.
Molecular and cellular biology 2003;23(20):7198-209.
2003: Kezhong Zhang; Randal J Kaufman
Unfolding the toxicity of cholesterol.
Nature cell biology 2003;5(9):769-70.
2003: Gazi S Hossain; Johannes V van Thienen; Geoff Werstuck; Ji Zhou; Sudesh K Sood; Jeffrey G Dickhout; A B Lawrence de Koning; Damu Tang; Dongcheng Wu; Erling Falk; Ranjana Poddar; Donald W Jacobsen; Kezhong Zhang; Randal J Kaufman; Richard C Austin
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia.
The Journal of biological chemistry 2003;278(32):30317-27.
2003: Hao-Yuan Jiang; Sheree A Wek; Barbara C McGrath; Donalyn Scheuner; Randal J Kaufman; Douglas R Cavener; Ronald C Wek
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Molecular and cellular biology 2003;23(16):5651-63.
2003: Martin Schröder; Robert Clark; Randal J Kaufman
IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast.
Molecular microbiology 2003;49(3):591-606.
2003: Tomoko Komiyama; Bryan VanderLugt; Martin Fugere; Robert Day; Randal J Kaufman; Robert S Fuller
Optimization of protease-inhibitor interactions by randomizing adventitious contacts.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8205-10.
2003: Ramachandra K Reddy; Changhui Mao; Peter Baumeister; Richard C Austin; Randal J Kaufman; Amy S Lee
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.
The Journal of biological chemistry 2003;278(23):20915-24.
2003: Bin Zhang; Michael A Cunningham; William C Nichols; John A Bernat; Uri Seligsohn; Steven W Pipe; John H McVey; Ursula Schulte-Overberg; Norma de Bosch; Arlette Ruiz-Saez; Gilbert C White; Edward G D Tuddenham; Randal J Kaufman; David Ginsburg
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
Nature genetics 2003;34(2):220-5.
2003: Ibrahim Yaman; James Fernandez; Haiyan Liu; Mark G Caprara; Anton A Komar; Antonis E Koromilas; Lingyin Zhou; Martin D Snider; Donalyn Scheuner; Randal J Kaufman; Maria Hatzoglou
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.
Cell 2003;113(4):519-31.
2003: Rai Knee; Irfan Ahsan; Nasrin Mesaeli; Randal J Kaufman; Marek Michalak
Compromised calnexin function in calreticulin-deficient cells.
Biochemical and biophysical research communications 2003;304(4):661-6.
2003: Chuan Yin Liu; Zhaohui Xu; Randal J Kaufman
Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.
The Journal of biological chemistry 2003;278(20):17680-7.
2003: Chuan Yin Liu; Randal J Kaufman
The unfolded protein response.
Journal of cell science 2003;116(Pt 10):1861-2.
2003: Kyungho Lee; Lenore Neigeborn; Randal J Kaufman
The unfolded protein response is required for haploid tolerance in yeast.
The Journal of biological chemistry 2003;278(14):11818-27.
2003: D Thomas Rutkowski; Randal J Kaufman
All roads lead to ATF4.
Developmental cell 2003;4(4):442-4.
2003: Stephen L Ward; Donalyn Scheuner; Jeremy Poppers; Randal J Kaufman; Ian Mohr; David A Leib
In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.
Journal of virology 2003;77(8):4626-34.
2003: Hiderou Yoshida; Toshie Matsui; Nobuko Hosokawa; Randal J Kaufman; Kazuhiro Nagata; Kazutoshi Mori
A time-dependent phase shift in the mammalian unfolded protein response.
Developmental cell 2003;4(2):265-71.
2002: Robert E Kingston; Randal J Kaufman; C R Bebbington; M R Rolfe
Amplification using CHO cell expression vectors.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2002;Chapter 16():Unit 16.23.
2002: Randal J Kaufman
Orchestrating the unfolded protein response in health and disease.
The Journal of clinical investigation 2002;110(10):1389-98.
2002: William H Hakeos; Hongzhi Miao; Nongnuch Sirachainan; Geoffrey Kemball-Cook; Evgueni L Saenko; Randal J Kaufman; Steven W Pipe
Hemophilia A mutations within the factor VIII A2-A3 subunit interface destabilize factor VIIIa and cause one-stage/two-stage activity discrepancy.
Thrombosis and haemostasis 2002;88(5):781-7.
2002: Jing Deng; Heather P Harding; Brian Raught; Anne-Claude Gingras; Juan Jose Berlanga; Donalyn Scheuner; Randal J Kaufman; David Ron; Nahum Sonenberg
Activation of GCN2 in UV-irradiated cells inhibits translation.
Current biology : CB 2002;12(15):1279-86.
2002: Randal J Kaufman; Donalyn Scheuner; Martin Schröder; Xiaohua Shen; Kyungho Lee; Chuan Yin Liu; Stacey Marie Arnold
The unfolded protein response in nutrient sensing and differentiation.
Nature reviews. Molecular cell biology 2002;3(6):411-21.
2002: Chuan Yin Liu; Hetty N Wong; Joseph A Schauerte; Randal J Kaufman
The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain.
The Journal of biological chemistry 2002;277(21):18346-56.
2002: Shiyong Wu; Yuanyuan Hu; Ju-Lin Wang; Madhumita Chatterjee; Yuguang Shi; Randal J Kaufman
Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum.
The Journal of biological chemistry 2002;277(20):18077-83.
2002: Gary E Gilbert; Randal J Kaufman; Andrew A Arena; Hongzhi Miao; Steven W Pipe
Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs.
The Journal of biological chemistry 2002;277(8):6374-81.
2002: Kyungho Lee; Witoon Tirasophon; Xiaohua Shen; Marek Michalak; Ron Prywes; Tetsuya Okada; Hiderou Yoshida; Kazutoshi Mori; Randal J Kaufman
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Genes & development 2002;16(4):452-66.
2002: Zsolt Tallóczy; Wenxia Jiang; Herbert W Virgin; David A Leib; Donalyn Scheuner; Randal J Kaufman; Eeva-Liisa Eskelinen; Beth Levine
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):190-5.
2001: Xiaohua Shen; Ronald E. Ellis; K Lee; C Y Liu; K Yang; A Solomon; Hiderou Yoshida; R Morimoto; David M Kurnit; K Mori; Randal J Kaufman
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
Cell 2001;107(7):893-903.
2001: Chun Zhang; Y Cai; Mimi T Adachi; Satoru Oshiro; Teijiro Aso; Randal J Kaufman; Shigetaka Kitajima
Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.
The Journal of biological chemistry 2001;276(38):35867-74.
2001: Anna L Scarim; M Arnush; Libby A Blair; J Concepcion; Monique R Heitmeier; Donalyn Scheuner; Randal J Kaufman; Jan S Ryerse; R Mark L Buller; John A Corbett
Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.
The American journal of pathology 2001;159(1):273-83.
2001: Donalyn Scheuner; Benbo Song; Edward McEwen; C Liu; R Laybutt; P Gillespie; Thomas L Saunders; S Bonner-Weir; Randal J Kaufman
Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
Molecular cell 2001;7(6):1165-76.
2001: Steven W Pipe; Evgueni L Saenko; A N Eickhorst; Geoffrey Kemball-Cook; Randal J Kaufman
Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa.
Blood 2001;97(3):685-91.
2000: Martin Schröder; J S Chang; Randal J Kaufman
The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast.
Genes & development 2000;14(23):2962-75.
2000: Witoon Tirasophon; Kyungho Lee; B Callaghan; Ajith Welihinda; Randal J Kaufman
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response.
Genes & development 2000;14(21):2725-36.
2000: A Sudhakar; A Ramachandran; S Ghosh; Seyed E Hasnain; Randal J Kaufman; Kolluru V A Ramaiah
Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B.
Biochemistry 2000;39(42):12929-38.
2000: Randal J Kaufman
Overview of vector design for mammalian gene expression.
Molecular biotechnology 2000;16(2):151-60.
2000: Y Wang; Jingshi Shen; N Arenzana; Witoon Tirasophon; Randal J Kaufman; Ron Prywes
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.
The Journal of biological chemistry 2000;275(35):27013-20.
2000: Chuan Yin Liu; M Schröder; Randal J Kaufman
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.
The Journal of biological chemistry 2000;275(32):24881-5.
2000: Leonard Bruno Maggi; Monique R Heitmeier; Donalyn Scheuner; Randal J Kaufman; R Mark L Buller; John A Corbett
Potential role of PKR in double-stranded RNA-induced macrophage activation.
The EMBO journal 2000;19(14):3630-8.
2000: Stacey Marie Arnold; Liselotte I Fessler; John H Fessler; Randal J Kaufman
Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.
Biochemistry 2000;39(9):2149-63.
2000: Steven W Pipe; Randal J Kaufman
A chamber of hope for hemophilia.
Nature biotechnology 2000;18(3):264-5.
2000: Luigina Tagliavacca; Q Wang; Randal J Kaufman
ATP-dependent dissociation of non-disulfide-linked aggregates of coagulation factor VIII is a rate-limiting step for secretion.
Biochemistry 2000;39(8):1973-81.
2000: Ajith Welihinda; Witoon Tirasophon; Randal J Kaufman
The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo.
The Journal of biological chemistry 2000;275(5):3377-81.
1999: Maho Niwa; C Sidrauski; Randal J Kaufman; Peter Walter
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response.
Cell 1999;99(7):691-702.
1999: A Sudhakar; T Krishnamoorthy; A Jain; U Chatterjee; Seyed E Hasnain; Randal J Kaufman; Kolluru V A Ramaiah
Serine 48 in initiation factor 2 alpha (eIF2 alpha) is required for high-affinity interaction between eIF2 alpha(P) and eIF2B.
Biochemistry 1999;38(46):15398-405.
1999: MJ Moussalli; Steven W Pipe; Hans-Peter Hauri; William C Nichols; David Ginsburg; Randal J Kaufman
Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII.
The Journal of biological chemistry 1999;274(46):32539-42.
1999: DM Foti; A Welihinda; Randal J Kaufman; Amy S Lee
Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1.
The Journal of biological chemistry 1999;274(43):30402-9.
1999: Randal J Kaufman
Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11693-5.
1999: Randal J Kaufman
Advances toward gene therapy for hemophilia at the millennium.
Human gene therapy 1999;10(13):2091-107.
1999: Randal J Kaufman; Steven W Pipe
Regulation of factor VIII expression and activity by von Willebrand factor.
Thrombosis and haemostasis 1999;82(2):201-8.
1999: Randal J Kaufman
Correction of genetic disease by making sense from nonsense.
The Journal of clinical investigation 1999;104(4):367-8.
1999: Randal J Kaufman
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.
Genes & development 1999;13(10):1211-33.
1999: E Thorelli; Randal J Kaufman; Björn Dahlbäck
Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V.
Blood 1999;93(8):2552-8.
1999: William C Nichols; Valeri Terry; M A Wheatley; A Yang; A Zivelin; N Ciavarella; C Stefanile; T Matsushita; H Saito; Norma de Bosch; Arlette Ruiz-Saez; A Torres; A R Thompson; D I Feinstein; Gilbert C White; Claude Negrier; Christine Vinciguerra; M Aktan; Randal J Kaufman; David Ginsburg; Uri Seligsohn
ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families.
Blood 1999;93(7):2261-6.
1999: Mary J Heeb; Alnawaz Rehemtulla; M Moussalli; Yumi Kojima; Randal J Kaufman
Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.
European journal of biochemistry / FEBS 1999;260(1):64-75.
1999: Donald J DeGracia; S Adamczyk; Adam Folbe; L L Konkoly; J E Pittman; Robert W Neumar; Jonathon M. Sullivan; Donalyn Scheuner; Randal J Kaufman; Blaine C White; Gary S Krause
Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion.
Experimental neurology 1999;155(2):221-7.
1999: Sheila Connelly; Julie L Andrews; AM Gallo-Penn; Luigina Tagliavacca; Randal J Kaufman; Michael Kaleko
Evaluation of an adenoviral vector encoding full-length human factor VIII in hemophiliac mice.
Thrombosis and haemostasis 1999;81(2):234-9.
1999: KU Kumar; S P Srivastava; Randal J Kaufman
Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18.
Molecular and cellular biology 1999;19(2):1116-25.
1999: Randal J Kaufman
Molecular chaperones and the heat shock response. Sponsored by Cold Spring Harbor Laboratory, 6-10 May 1998.
Biochimica et biophysica acta 1999;1423(1):R13-27.
1999: Ajith Welihinda; Witoon Tirasophon; Randal J Kaufman
The cellular response to protein misfolding in the endoplasmic reticulum.
Gene expression 1999;7(4-6):293-300.
1999: Randal J Kaufman; Andrew J Dorner; D N Fass
von Willebrand factor elevates plasma factor VIII without induction of factor VIII messenger RNA in the liver.
Blood 1999;93(1):193-7.
1999: Steven W Pipe; A N Eickhorst; S H McKinley; Evgueni L Saenko; Randal J Kaufman
Mild hemophilia A caused by increased rate of factor VIII A2 subunit dissociation: evidence for nonproteolytic inactivation of factor VIIIa in vivo.
Blood 1999;93(1):176-83.
1998: Shiyong Wu; KU Kumar; Randal J Kaufman
Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR).
Biochemistry 1998;37(39):13816-26.
1998: A V Bendetowicz; J A Morris; R J Wise; Gary E Gilbert; Randal J Kaufman
Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers.
Blood 1998;92(2):529-38.
1998: David Ginsburg; William C Nichols; A Zivelin; Randal J Kaufman; Uri Seligsohn
Combined factors V and VIII deficiency--the solution.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):677-82.
1998: Randal J Kaufman; Steven W Pipe
Can we improve on nature? "Super molecules" of factor VIII.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):370-9.
1998: E Thorelli; Randal J Kaufman; Björn Dahlbäck
Cleavage requirements of factor V in tissue-factor induced thrombin generation.
Thrombosis and haemostasis 1998;80(1):92-8.
1998: E Thorelli; Randal J Kaufman; Björn Dahlbäck
The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V.
The Journal of biological chemistry 1998;273(26):16140-5.
1998: Witoon Tirasophon; Ajith Welihinda; Randal J Kaufman
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.
Genes & development 1998;12(12):1812-24.
1998: Tony L Yang; J Cui; A Rehumtulla; Angela Yang; MJ Moussalli; Randal J Kaufman; David Ginsburg
The structure and function of murine factor V and its inactivation by protein C.
Blood 1998;91(12):4593-9.
1998: Randal J Kaufman
Post-translational modifications required for coagulation factor secretion and function.
Thrombosis and haemostasis 1998;79(6):1068-79.
1998: William C Nichols; Uri Seligsohn; A Zivelin; Valeri Terry; C E Hertel; M A Wheatley; MJ Moussalli; Hans-Peter Hauri; N Ciavarella; Randal J Kaufman; David Ginsburg
Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII.
Cell 1998;93(1):61-70.
1998: Steven W Pipe; J A Morris; J Shah; Randal J Kaufman
Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.
The Journal of biological chemistry 1998;273(14):8537-44.
1998: Ajith Welihinda; Witoon Tirasophon; S R Green; Randal J Kaufman
Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.
Molecular and cellular biology 1998;18(4):1967-77.
1998: K Amano; D A Michnick; MJ Moussalli; Randal J Kaufman
Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.
Thrombosis and haemostasis 1998;79(3):557-63.
1998: Jonathan B Rosenberg; P A Foster; Randal J Kaufman; E A Vokac; M Moussalli; Philip A Kroner; Robert R Montgomery
Intracellular trafficking of factor VIII to von Willebrand factor storage granules.
The Journal of clinical investigation 1998;101(3):613-24.
1998: S P Srivastava; KU Kumar; Randal J Kaufman
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase.
The Journal of biological chemistry 1998;273(4):2416-23.
1998: K Amano; R Sarkar; S Pemberton; Geoffrey Kemball-Cook; Haig Kazazian ; Randal J Kaufman
The molecular basis for cross-reacting material-positive hemophilia A due to missense mutations within the A2-domain of factor VIII.
Blood 1998;91(2):538-48.
1997: Randal J Kaufman; Steven W Pipe; Luigina Tagliavacca; M Swaroop; MJ Moussalli
Biosynthesis, assembly and secretion of coagulation factor VIII.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8 Suppl 2():S3-14.
1997: Steven W Pipe; Randal J Kaufman
Characterization of a genetically engineered inactivation-resistant coagulation factor VIIIa.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11851-6.
1997: Luigina Tagliavacca; Namdoo Moon; W Richard Dunham; Randal J Kaufman
Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII.
The Journal of biological chemistry 1997;272(43):27428-34.
1997: M Swaroop; MJ Moussalli; Steven W Pipe; Randal J Kaufman
Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII.
The Journal of biological chemistry 1997;272(39):24121-4.
1997: E Thorelli; Randal J Kaufman; Björn Dahlbäck
Cleavage requirements for activation of factor V by factor Xa.
European journal of biochemistry / FEBS 1997;247(1):12-20.
1997: Ajith Welihinda; Witoon Tirasophon; S R Green; Randal J Kaufman
Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4289-94.
1997: Randal J Kaufman
DNA transfection to study translational control in mammalian cells.
Methods (San Diego, Calif.) 1997;11(4):361-70.
1997: William C Nichols; Uri Seligsohn; A Zivelin; Valeri Terry; N D Arnold; DR Siemieniak; Randal J Kaufman; David Ginsburg
Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping.
The Journal of clinical investigation 1997;99(4):596-601.
1997: J A Morris; Andrew J Dorner; C A Edwards; L M Hendershot; Randal J Kaufman
Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins.
The Journal of biological chemistry 1997;272(7):4327-34.
1997: Shiyong Wu; Randal J Kaufman
A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.
The Journal of biological chemistry 1997;272(2):1291-6.
1997: Randal J Kaufman
Overview of vector design for mammalian gene expression.
Methods in molecular biology (Clifton, N.J.) 1997;62():287-300.
1996: Steven W Pipe; Randal J Kaufman
Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins.
The Journal of biological chemistry 1996;271(41):25671-6.
1996: Charles O Brostrom; C R Prostko; Randal J Kaufman; Margaret A Brostrom
Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha kinase.
The Journal of biological chemistry 1996;271(40):24995-5002.
1996: Karen L Mohlke; William C Nichols; Alnawaz Rehemtulla; Randal J Kaufman; H M Fagerström; K L Ritvanen; R Kekomăki; David Ginsburg
A common frameshift mutation in von Willebrand factor does not alter mRNA stability but interferes with normal propeptide processing.
British journal of haematology 1996;95(1):184-91.
1996: William C Nichols; K Amano; P M Cacheris; M S Figueiredo; K Michaelides; Rainer Schwaab; L Hoyer; Randal J Kaufman; David Ginsburg
Moderation of hemophilia A phenotype by the factor V R506Q mutation.
Blood 1996;88(4):1183-7.
1996: Ajith Welihinda; Randal J Kaufman
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation.
The Journal of biological chemistry 1996;271(30):18181-7.
1996: S Wu; Alnawaz Rehemtulla; NK Gupta; Randal J Kaufman
A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells.
Biochemistry 1996;35(25):8275-80.
1996: Philip J Fay; T L Beattie; L M Regan; L M O'Brien; Randal J Kaufman
Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis.
The Journal of biological chemistry 1996;271(11):6027-32.
1996: Shiyong Wu; Randal J Kaufman
Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).
The Journal of biological chemistry 1996;271(3):1756-63.
1996: D I Israel; J Nove; K M Kerns; Randal J Kaufman; Vicki Rosen; K A Cox; John M Wozney
Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo.
Growth factors (Chur, Switzerland) 1996;13(3-4):291-300.
1995: R Drews; RK Paleyanda; T K Lee; R R Chang; Alnawaz Rehemtulla; Randal J Kaufman; W N Drohan; H Luboń
Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10462-6.
1995: K A Marquette; D D Pittman; Randal J Kaufman
The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain.
Blood 1995;86(8):3026-34.
1995: S P Srivastava; M V Davies; Randal J Kaufman
Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis.
The Journal of biological chemistry 1995;270(28):16619-24.
1995: K A Marquette; D D Pittman; Randal J Kaufman
A 110-amino acid region within the A1-domain of coagulation factor VIII inhibits secretion from mammalian cells.
The Journal of biological chemistry 1995;270(17):10297-303.
1994: D D Pittman; K A Marquette; Randal J Kaufman
Role of the B domain for factor VIII and factor V expression and function.
Blood 1994;84(12):4214-25.
1994: Randal J Kaufman
Control of gene expression at the level of translation initiation.
Current opinion in biotechnology 1994;5(5):550-7.
1994: Randal J Kaufman; M Swaroop; P Murtha-Riel
Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells.
Biochemistry 1994;33(33):9813-9.
1994: D A Michnick; D D Pittman; R J Wise; Randal J Kaufman
Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.
The Journal of biological chemistry 1994;269(31):20095-102.
1994: K V Ramaiah; M V Davies; J J Chen; Randal J Kaufman
Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation.
Molecular and cellular biology 1994;14(7):4546-53.
1994: D D Pittman; K N Tomkinson; Randal J Kaufman
Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.
The Journal of biological chemistry 1994;269(25):17329-37.
1994: D D Pittman; K N Tomkinson; D Michnick; U Selighsohn; Randal J Kaufman
Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Biochemistry 1994;33(22):6952-9.
1994: A J Dorner; Randal J Kaufman
The levels of endoplasmic reticulum proteins and ATP affect folding and secretion of selective proteins.
Biologicals : journal of the International Association of Biological Standardization 1994;22(2):103-12.
1994: H Park; M V Davies; J O Langland; H W Chang; Y S Nam; J Tartaglia; E Paoletti; Bertram L Jacobs; Randal J Kaufman; S Venkatesan
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4713-7.
1993: Alnawaz Rehemtulla; P J Barr; C J Rhodes; Randal J Kaufman
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
Biochemistry 1993;32(43):11586-90.
1993: David A Roth; Alnawaz Rehemtulla; Randal J Kaufman; Christopher T Walsh; Bruce Furie; Barbara C Furie
Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8372-6.
1993: P Murtha-Riel; M V Davies; B J Scherer; S Y Choi; John W B Hershey; Randal J Kaufman
Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis.
The Journal of biological chemistry 1993;268(17):12946-51.
1993: Randal J Kaufman; P Murtha-Riel; D D Pittman; M V Davies
Characterization of wild-type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells.
The Journal of biological chemistry 1993;268(16):11902-9.
1993: D D Pittman; E M Alderman; K N Tomkinson; J H Wang; Alan Giles; Randal J Kaufman
Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII.
Blood 1993;81(11):2925-35.
1993: C M Lynch; D I Israel; Randal J Kaufman; A Dusty Miller
Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production.
Human gene therapy 1993;4(3):259-72.
1993: M J Clemens; J W Hershey; A C Hovanessian; B C Jacobs; M G Katze; Randal J Kaufman; P Lengyel; C E Samuel; G C Sen; B R Williams
PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon.
Journal of interferon research 1993;13(3):241.
1993: Alnawaz Rehemtulla; David A Roth; L C Wasley; A Kuliopulos; Christopher T Walsh; Bruce Furie; Barbara C Furie; Randal J Kaufman
In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4611-5.
1993: D I Israel; Randal J Kaufman
Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/glucocorticoid receptor protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4290-4.
1993: L C Wasley; Alnawaz Rehemtulla; J A Bristol; Randal J Kaufman
PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway.
The Journal of biological chemistry 1993;268(12):8458-65.
1993: M V Davies; H W Chang; Bertram L Jacobs; Randal J Kaufman
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.
Journal of virology 1993;67(3):1688-92.
1993: D D Pittman; Randal J Kaufman
Site-directed mutagenesis and expression of coagulation factors VIII and V in mammalian cells.
Methods in enzymology 1993;222():236-60.
1992: Randal J Kaufman
Expression and structure-function properties of recombinant factor VIII.
Transfusion medicine reviews 1992;6(4):235-46.
1992: Alnawaz Rehemtulla; Randal J Kaufman
Protein processing within the secretory pathway.
Current opinion in biotechnology 1992;3(5):560-5.
1992: M V Davies; Randal J Kaufman
Internal translation initiation in the design of improved expression vectors.
Current opinion in biotechnology 1992;3(5):512-7.
1992: Alnawaz Rehemtulla; A J Dorner; Randal J Kaufman
Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8235-9.
1992: Alnawaz Rehemtulla; Randal J Kaufman
Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes.
Blood 1992;79(9):2349-55.
1992: D D Pittman; J H Wang; Randal J Kaufman
Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII.
Biochemistry 1992;31(13):3315-25.
1992: A J Dorner; L C Wasley; Randal J Kaufman
Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.
The EMBO journal 1992;11(4):1563-71.
1992: M V Davies; O Elroy-Stein; R Jagus; Bernard Moss; Randal J Kaufman
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
Journal of virology 1992;66(4):1943-50.
1992: M V Davies; Randal J Kaufman
The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation.
Journal of virology 1992;66(4):1924-32.
1992: H M Koo; A M Brown; Randal J Kaufman; C M Prorock; Yacov Ron; Joseph P Dougherty
A spleen necrosis virus-based retroviral vector which expresses two genes from a dicistronic mRNA.
Virology 1992;186(2):669-75.
1992: D D Pittman; M Millenson; K Marquette; K Bauer; Randal J Kaufman
A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage.
Blood 1992;79(2):389-97.
1992: S Y Choi; B J Scherer; Joachim B Schnier; M V Davies; Randal J Kaufman; John W B Hershey
Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2.
The Journal of biological chemistry 1992;267(1):286-93.
1992: Randal J Kaufman
Biological regulation of factor VIII activity.
Annual review of medicine 1992;43():325-39.
1992: A C Chang; J N Nunberg; Randal J Kaufman; Henry A Erlich; R T Schimke; S N Cohen
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. 1978.
Biotechnology (Reading, Mass.) 1992;24():330-6.
1992: D I Israel; J Nove; K M Kerns; I K Moutsatsos; Randal J Kaufman
Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells.
Growth factors (Chur, Switzerland) 1992;7(2):139-50.
1991: R J Wise; A J Dorner; M Krane; D D Pittman; Randal J Kaufman
The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.
The Journal of biological chemistry 1991;266(32):21948-55.
1991: Randal J Kaufman
Developing rDNA products for treatment of hemophilia A.
Trends in biotechnology 1991;9(10):353-9.
1991: Michael E Nesheim; D D Pittman; Alan Giles; D N Fass; J H Wang; D Slonosky; Randal J Kaufman
The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets.
The Journal of biological chemistry 1991;266(27):17815-20.
1991: Clive R Wood; G E Morris; E M Alderman; L Fouser; Randal J Kaufman
An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8006-10.
1991: Randal J Kaufman
Insight into the structure, function, and biosynthesis of factor VIII through recombinant DNA technology.
Annals of hematology 1991;63(3):155-65.
1991: A J Dorner; F Bonneville; Ron Kriz; Kerry Kelleher; K Bean; Randal J Kaufman
Molecular cloning and characterization of a complete Chinese hamster provirus related to intracisternal A particle genomes.
Journal of virology 1991;65(9):4713-9.
1991: Randal J Kaufman; M V Davies; L C Wasley; D Michnick
Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus.
Nucleic acids research 1991;19(16):4485-90.
1991: M V Davies; J Pelletier; Karen Meerovitch; N Sonenberg; Randal J Kaufman
The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation.
The Journal of biological chemistry 1991;266(22):14714-20.
1991: L C Wasley; G Timony; P Murtha; J Stoudemire; A J Dorner; J Caro; M Krieger; Randal J Kaufman
The importance of N- and O-linked oligosaccharides for the biosynthesis and in vitro and in vivo biologic activities of erythropoietin.
Blood 1991;77(12):2624-32.
1991: T L Messier; D D Pittman; George L Long; Randal J Kaufman; W R Church
Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.
Gene 1991;99(2):291-4.
1990: A J Dorner; L C Wasley; P Raney; S Haugejorden; M Green; Randal J Kaufman
The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.
The Journal of biological chemistry 1990;265(35):22029-34.
1990: R J Wise; P J Barr; P A Wong; M C Kiefer; A J Brake; Randal J Kaufman
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9378-82.
1990: L S Lum; L A Sultzman; Randal J Kaufman; Daniel I H Linzer; B J Wu
A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter.
Molecular and cellular biology 1990;10(12):6709-17.
1990: Randal J Kaufman
Mammalian recombinant proteins: structure, function and immunological analysis.
Current opinion in biotechnology 1990;1(2):141-50.
1990: Clive R Wood; A J Dorner; G E Morris; E M Alderman; D Wilson; R M O'Hara; Randal J Kaufman
High level synthesis of immunoglobulins in Chinese hamster ovary cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):3011-6.
1990: A J Dorner; L C Wasley; Randal J Kaufman
Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7429-32.
1990: S C Milburn; John W B Hershey; M V Davies; K Kelleher; Randal J Kaufman
Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.
The EMBO journal 1990;9(9):2783-90.
1990: D I Israel; Randal J Kaufman
Retroviral-mediated transfer and amplification of a functional human factor VIII gene.
Blood 1990;75(5):1074-80.
1990: A J Dorner; Randal J Kaufman
Analysis of synthesis, processing, and secretion of proteins expressed in mammalian cells.
Methods in enzymology 1990;185():577-96.
1990: Randal J Kaufman
Use of recombinant DNA technology for engineering mammalian cells to produce proteins.
Bioprocess technology 1990;10():15-69.
1990: Randal J Kaufman
Control of translation initiation in mammalian cells.
Genetic engineering 1990;12():243-73.
1989: A J Dorner; L C Wasley; Randal J Kaufman
Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells.
The Journal of biological chemistry 1989;264(34):20602-7.
1989: M V Davies; M Furtado; J W Hershey; B Thimmappaya; Randal J Kaufman
Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9163-7.
1989: Randal J Kaufman
Genetic engineering of factor VIII.
Nature 1989;342(6246):207-8.
1989: Zeljka Smit-McBride; Joachim B Schnier; Randal J Kaufman; John W B Hershey
Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein.
The Journal of biological chemistry 1989;264(31):18527-30.
1989: D I Israel; Randal J Kaufman
Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptor.
Nucleic acids research 1989;17(12):4589-604.
1989: Claudia Derian; W VanDusen; C T Przysiecki; P N Walsh; K L Berkner; Randal J Kaufman; P A Friedman
Inhibitors of 2-ketoglutarate-dependent dioxygenases block aspartyl beta-hydroxylation of recombinant human factor IX in several mammalian expression systems.
The Journal of biological chemistry 1989;264(12):6615-8.
1989: D D Pittman; Randal J Kaufman
Structure-function relationships of factor VIII elucidated through recombinant DNA technology.
Thrombosis and haemostasis 1989;61(2):161-5.
1989: S K Jang; M V Davies; Randal J Kaufman; Eckard Wimmer
Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo.
Journal of virology 1989;63(4):1651-60.
1989: Randal J Kaufman; M V Davies; Vinay Pathak; John W B Hershey
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.
Molecular and cellular biology 1989;9(3):946-58.
1989: Randal J Kaufman; L C Wasley; M V Davies; R J Wise; D I Israel; A J Dorner
Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.
Molecular and cellular biology 1989;9(3):1233-42.
1988: Michael E Nesheim; D D Pittman; J H Wang; D Slonosky; Alan Giles; Randal J Kaufman
The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets.
The Journal of biological chemistry 1988;263(31):16467-70.
1988: A J Dorner; M G Krane; Randal J Kaufman
Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells.
Molecular and cellular biology 1988;8(10):4063-70.
1988: Randal J Kaufman; L C Wasley; A J Dorner
Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.
The Journal of biological chemistry 1988;263(13):6352-62.
1988: D D Pittman; Randal J Kaufman
Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII).
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2429-33.
1988: R J Wise; D D Pittman; R I Handin; Randal J Kaufman; Stuart H Orkin
The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers.
Cell 1988;52(2):229-36.
1987: A J Dorner; D G Bole; Randal J Kaufman
The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins.
The Journal of cell biology 1987;105(6 Pt 1):2665-74.
1987: D D Oprian; R S Molday; Randal J Kaufman; H Gobind Khorana
Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8874-8.
1987: O J Nielsen; SJ Schuster; Randal J Kaufman; A J Erslev; Jaime Caro
Regulation of erythropoietin production in a human hepatoblastoma cell line.
Blood 1987;70(6):1904-9.
1987: L C Wasley; D H Atha; K A Bauer; Randal J Kaufman
Expression and characterization of human antithrombin III synthesized in mammalian cells.
The Journal of biological chemistry 1987;262(30):14766-72.
1987: R J Jenny; D D Pittman; J J Toole; Ron Kriz; R A Aldape; R M Hewick; Randal J Kaufman; K G Mann
Complete cDNA and derived amino acid sequence of human factor V.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(14):4846-50.
1987: Randal J Kaufman; P Murtha
Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells.
Molecular and cellular biology 1987;7(4):1568-71.
1987: G G Wong; P A Temple; A C Leary; J S Witek-Giannotti; Y C Yang; A B Ciarletta; M Chung; P Murtha; Ron Kriz; Randal J Kaufman
Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
Science (New York, N.Y.) 1987;235(4795):1504-8.
1987: J Ting; S K Wooden; Ron Kriz; Kerry Kelleher; Randal J Kaufman; Amy S Lee
The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat.
Gene 1987;55(1):147-52.
1987: Randal J Kaufman; P Murtha; M V Davies
Translational efficiency of polycistronic mRNAs and their utilization to express heterologous genes in mammalian cells.
The EMBO journal 1987;6(1):187-93.
1986: D T Bonthron; R I Handin; Randal J Kaufman; L C Wasley; E C Orr; L M Mitsock; Bruce M Ewenstein; J Loscalzo; David Ginsburg; Stuart H Orkin
Structure of pre-pro-von Willebrand factor and its expression in heterologous cells.
Nature 1986;324(6094):270-3.
1986: J J Toole; D D Pittman; E C Orr; P Murtha; L C Wasley; Randal J Kaufman
A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5939-42.
1986: Randal J Kaufman; L C Wasley; B C Furie; B Furie; C B Shoemaker
Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.
The Journal of biological chemistry 1986;261(21):9622-8.
1986: Randal J Kaufman; P Murtha; D E Ingolia; C Y Yeung; Rodney E Kellems
Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3136-40.
1986: D E Ingolia; C Y Yeung; C Shoemaker; Randal J Kaufman; Rodney E Kellems
Expression of murine ADA cDNA in bacterial and mammalian cells.
Advances in experimental medicine and biology 1986;195 Pt A():223-9.
1986: Robert E Donahue; E A Wang; Randal J Kaufman; L Foutch; A C Leary; J S Witek-Giannetti; Mark E Metzger; R M Hewick; D R Steinbrink; G Shaw
Effects of N-linked carbohydrate on the in vivo properties of human GM-CSF.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():685-92.
1986: B Fendrock; M Destrempes; Randal J Kaufman; S A Latt
Cytological, flow cytometric, and molecular analysis of the rapid evolution of mammalian chromosomes containing highly amplified DNA sequences.
Histochemistry 1986;84(2):121-30.
1986: J J Toole; D Pittman; P Murtha; L C Wasley; J Wang; G Amphlett; R Hewick; W B Foster; R Kamen; Randal J Kaufman
Exploration of structure-function relationships in human factor VIII by site-directed mutagenesis.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():543-9.
1985: C Y Yeung; D E Ingolia; David B Roth; C Shoemaker; Muayyad R Al-Ubaidi; J Y Yen; C Ching; C Bobonis; Randal J Kaufman; Rodney E Kellems
Identification of functional murine adenosine deaminase cDNA clones by complementation in Escherichia coli.
The Journal of biological chemistry 1985;260(18):10299-307.
1985: Randal J Kaufman; L C Wasley; A J Spiliotes; S D Gossels; S A Latt; G R Larsen; R M Kay
Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells.
Molecular and cellular biology 1985;5(7):1750-9.
1985: Judith C Gasson; David W Golde; S E Kaufman; C A Westbrook; R M Hewick; Randal J Kaufman; G G Wong; P A Temple; A C Leary; E L Brown
Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.
Nature 1985;315(6022):768-71.
1985: K Jacobs; C Shoemaker; R Rudersdorf; S D Neill; Randal J Kaufman; A Mufson; J Seehra; S S Jones; R Hewick; E F Fritsch
Isolation and characterization of genomic and cDNA clones of human erythropoietin.
Nature 1985;313(6005):806-10.
1985: Randal J Kaufman
Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(3):689-93.
1984: J J Toole; J L Knopf; J M Wozney; L A Sultzman; J L Buecker; D D Pittman; Randal J Kaufman; E Brown; C Shoemaker; E C Orr
Molecular cloning of a cDNA encoding human antihaemophilic factor.
Nature 1984;312(5992):342-7.
1984: R E Kingston; Randal J Kaufman; Phillip A Sharp
Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity.
Molecular and cellular biology 1984;4(10):1970-7.
1984: S C Clark; S K Arya; F Wong-Staal; M Matsumoto-Kobayashi; R M Kay; Randal J Kaufman; E L Brown; C Shoemaker; T Copeland; S Oroszlan
Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(8):2543-7.
1983: Randal J Kaufman; Phillip A Sharp
Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes.
Molecular and cellular biology 1983;3(9):1598-608.
1983: Randal J Kaufman; Phillip A Sharp; S A Latt
Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.
Molecular and cellular biology 1983;3(4):699-711.
1983: M J Murray; Randal J Kaufman; S A Latt; Robert A. Weinberg
Construction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimera.
Molecular and cellular biology 1983;3(1):32-43.
1982: Randal J Kaufman; Phillip A Sharp
Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression.
Molecular and cellular biology 1982;2(11):1304-19.
1982: Randal J Kaufman; Phillip A Sharp
Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene.
Journal of molecular biology 1982;159(4):601-21.
1982: R T Schimke; P C Brown; Randal J Kaufman
Gene amplification and drug resistance in mammalian cells.
National Cancer Institute monograph 1982;60():79-86.
1981: Randal J Kaufman; P C Brown; R T Schimke
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.
Molecular and cellular biology 1981;1(12):1084-93.
1981: Randal J Kaufman; R T Schimke
Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.
Molecular and cellular biology 1981;1(12):1069-76.
1981: H Handa; Randal J Kaufman; J Manley; M Gefter; Phillip A Sharp
Transcription of Simian virus 40 DNA in a HeLa whole cell extract.
The Journal of biological chemistry 1981;256(1):478-82.
1981: R T Schimke; P C Brown; Randal J Kaufman; M McGrogan; D L Slate
Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():785-97.
1980: A C Chang; Henry A Erlich; R P Gunsalus; J H Nunberg; Randal J Kaufman; R T Schimke; S N Cohen
Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1442-6.
1980: J H Nunberg; Randal J Kaufman; A C Chang; S N Cohen; R T Schimke
Structure and genomic organization of the mouse dihydrofolate reductase gene.
Cell 1980;19(2):355-64.
1979: B J Dolnick; R J Berenson; J R Bertino; Randal J Kaufman; J H Nunberg; R T Schimke
Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.
The Journal of cell biology 1979;83(2 Pt 1):394-402.
1979: Randal J Kaufman; P C Brown; R T Schimke
Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5669-73.
1979: R T Schimke; Randal J Kaufman; J H Nunberg; S L Dana
Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells.
Cold Spring Harbor symposia on quantitative biology 1979;43 Pt 2():1297-303.
1978: R T Schimke; Randal J Kaufman; F W Alt; R F Kellems
Gene amplification and drug resistance in cultured murine cells.
Science (New York, N.Y.) 1978;202(4372):1051-5.
1978: J H Nunberg; Randal J Kaufman; R T Schimke; G Urlaub; L A Chasin
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(11):5553-6.
1978: A C Chang; J H Nunberg; Randal J Kaufman; Henry A Erlich; R T Schimke; S N Cohen
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.
Nature 1978;275(5681):617-24.
1978: Randal J Kaufman; J R Bertino; R T Schimke
Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter.
The Journal of biological chemistry 1978;253(16):5852-60.
1978: R T Schimke; F W Alt; R E Kellems; Randal J Kaufman; J R Bertino
Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells.
Cold Spring Harbor symposia on quantitative biology 1978;42 Pt 2():649-57.