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Randal Kaufman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
29
Scheuner, Donalyn
16
Pipe, Steven
16
Ginsburg, David
13
Zhang, Kezhong
10
Rehemtulla, Alnawaz
9
Song, Benbo
9
Nichols, William
8
Ron, David
8
Rutkowski, Thomas
8
Tirasophon, Witoon
7
Welihinda, Ajith
7
Liu, Chuan Yin
7
Harding, Heather
6
Lee, Kyungho
6
Moussalli, MJ

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Publications

TOP 3
DuRose Jenny B; Scheuner Donalyn; Kaufman Randal J; Rothblum Lawrence I; Niwa Maho
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.
Back Sung Hoon; Scheuner Donalyn; Han Jaeseok; Song Benbo; Ribick Mark; Wang Junying; Gildersleeve Robert D; Pennathur Subramaniam; Kaufman Randal J
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
Mokas Sophie; Mills John R; Garreau Cristina; Fournier Marie-Josée; Robert Francis; Arya Prabhat; Kaufman Randal J; Pelletier Jerry; Mazroui Rachid
Uncoupling stress granule assembly and translation initiation inhibition.

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All Publications

2009: DuRose Jenny B; Scheuner Donalyn; Kaufman Randal J; Rothblum Lawrence I; Niwa Maho
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.
Molecular and cellular biology 2009;29(15):4295-307.
2009: Back Sung Hoon; Scheuner Donalyn; Han Jaeseok; Song Benbo; Ribick Mark; Wang Junying; Gildersleeve Robert D; Pennathur Subramaniam; Kaufman Randal J
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
Cell metabolism 2009;10(1):13-26.
2009: Mokas Sophie; Mills John R; Garreau Cristina; Fournier Marie-Josée; Robert Francis; Arya Prabhat; Kaufman Randal J; Pelletier Jerry; Mazroui Rachid
Uncoupling stress granule assembly and translation initiation inhibition.
Molecular biology of the cell 2009;20(11):2673-83.
2009: Harding Heather P; Zhang Yuhong; Scheuner Donalyn; Chen Jane-Jane; Kaufman Randal J; Ron David
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1832-7.
2009: Wang Jiou; Farr George W; Zeiss Caroline J; Rodriguez-Gil Diego J; Wilson Jean H; Furtak Krystyna; Rutkowski D Thomas; Kaufman Randal J; Ruse Cristian I; Yates John R; Perrin Steve; Feany Mel B; Horwich Arthur L
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1392-7.
2009: Fribley Andrew; Zhang Kezhong; Kaufman Randal J
Regulation of apoptosis by the unfolded protein response.
Methods in molecular biology (Clifton, N.J.) 2009;559():191-204.
2008: Rutkowski D Thomas; Wu Jun; Back Sung-Hoon; Callaghan Michael U; Ferris Sean P; Iqbal Jahangir; Clark Robert; Miao Hongzhi; Hassler Justin R; Fornek Jamie; Katze Michael G; Hussain M Mahmood; Song Benbo; Swathirajan Jayanth; Wang Junying; Yau Grace D-Y; Kaufman Randal J
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
Developmental cell 2008;15(6):829-40.
2008: Malhotra Jyoti D; Miao Hongzhi; Zhang Kezhong; Wolfson Anna; Pennathur Subramaniam; Pipe Steven W; Kaufman Randal J
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18525-30.
2008: Kim Jinhwan; Choi Tae Gyu; Ding Yan; Kim Yeonghwan; Ha Kwon Soo; Lee Kyung Ho; Kang Insug; Ha Joohun; Kaufman Randal J; Lee Jinhwa; Choe Wonchae; Kim Sung Soo
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress.
Journal of cell science 2008;121(Pt 21):3636-48.
2008: Song Benbo; Scheuner Donalyn; Ron David; Pennathur Subramaniam; Kaufman Randal J
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
The Journal of clinical investigation 2008;118(10):3378-89.
2008: Luebke-Wheeler Jennifer; Zhang Kezhong; Battle Michele; Si-Tayeb Karim; Garrison Wendy; Chhinder Sodhi; Li Jixuan; Kaufman Randal J; Duncan Stephen A
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H.
Hepatology (Baltimore, Md.) 2008;48(4):1242-50.
2008: Yamamoto Keisuke; Suzuki Natsumi; Wada Tadashi; Okada Tetsuya; Yoshida Hiderou; Kaufman Randal J; Mori Kazutoshi
Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.
Journal of biochemistry 2008;144(4):477-86.
2008: Sakaki Kenjiro; Kaufman Randal J
Regulation of ER stress-induced macroautophagy by protein kinase C.
Autophagy 2008;4(6):841-3.
2008: Farhan Hesso; Weiss Matthias; Tani Katsuko; Kaufman Randal J; Hauri Hans-Peter
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load.
The EMBO journal 2008;27(15):2043-54.
2008: Mak Baldwin C; Wang Qin; Laschinger Carol; Lee Wilson; Ron David; Harding Heather P; Kaufman Randal J; Scheuner Donalyn; Austin Richard C; McCulloch Christopher A
Novel function of PERK as a mediator of force-induced apoptosis.
The Journal of biological chemistry 2008;283(34):23462-72.
2008: Zhang Kezhong; Kaufman Randal J
From endoplasmic-reticulum stress to the inflammatory response.
Nature 2008;454(7203):455-62.
2008: Zhang Bin; Spreafico Marta; Zheng Chunlei; Yang Angela; Platzer Petra; Callaghan Michael U; Avci Zekai; Ozbek Namik; Mahlangu Johnny; Haw Tabitha; Kaufman Randal J; Marchant Kandice; Tuddenham Edward G D; Seligsohn Uri; Peyvandi Flora; Ginsburg David
Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.
Blood 2008;111(12):5592-600.
2008: Scheuner Donalyn; Kaufman Randal J
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.
Endocrine reviews 2008;29(3):317-33.
2008: Sakaki Kenjiro; Wu Jun; Kaufman Randal J
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum.
The Journal of biological chemistry 2008;283(22):15370-80.
2008: Thiaville Michelle M; Pan Yuan-Xiang; Gjymishka Altin; Zhong Can; Kaufman Randal J; Kilberg Michael S
MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.
The Journal of biological chemistry 2008;283(16):10848-57.
2008: Zeenko Vladimir V; Wang Chuanping; Majumder Mithu; Komar Anton A; Snider Martin D; Merrick William C; Kaufman Randal J; Hatzoglou Maria
An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation.
RNA (New York, N.Y.) 2008;14(3):593-602.
2008: Zhang Kezhong; Kaufman Randal J
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo.
Methods in enzymology 2008;442():395-419.
2007: Malhotra Jyoti D; Kaufman Randal J
The endoplasmic reticulum and the unfolded protein response.
Seminars in cell & developmental biology 2007;18(6):716-31.
2007: Malhotra Jyoti D; Kaufman Randal J
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
Antioxidants & redox signaling 2007;9(12):2277-93.
2007: Cerullo Vincenzo; Seiler Michael P; Mane Viraj; Cela Racel; Clarke Christian; Kaufman Randal J; Pipe Steven W; Lee Brendan
Correction of murine hemophilia A and immunological differences of factor VIII variants delivered by helper-dependent adenoviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2080-7.
2007: Rutkowski D Thomas; Kaufman Randal J
That which does not kill me makes me stronger: adapting to chronic ER stress.
Trends in biochemical sciences 2007;32(10):469-76.
2007: Wu Jun; Rutkowski D Thomas; Dubois Meghan; Swathirajan Jayanth; Saunders Thomas; Wang Junying; Song Benbo; Yau Grace D-Y; Kaufman Randal J
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.
Developmental cell 2007;13(3):351-64.
2007: Rutkowski D Thomas; Kang Sang-Wook; Goodman Alan G; Garrison Jennifer L; Taunton Jack; Katze Michael G; Kaufman Randal J; Hegde Ramanujan S
The role of p58IPK in protecting the stressed endoplasmic reticulum.
Molecular biology of the cell 2007;18(9):3681-91.
2007: Renna Maurizio; Caporaso Maria Gabriella; Bonatti Stefano; Kaufman Randal J; Remondelli Paolo
Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress.
The Journal of biological chemistry 2007;282(31):22499-512.
2007: Soldà Tatiana; Galli Carmela; Kaufman Randal J; Molinari Maurizio
Substrate-specific requirements for UGT1-dependent release from calnexin.
Molecular cell 2007;27(2):238-49.
2007: Drogat Benjamin; Auguste Patrick; Nguyen Duc Thang; Bouchecareilh Marion; Pineau Raphael; Nalbantoglu Josephine; Kaufman Randal J; Chevet Eric; Bikfalvi Andréas; Moenner Michel
IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.
Cancer research 2007;67(14):6700-7.
2007: Mazroui Rachid; Di Marco Sergio; Kaufman Randal J; Gallouzi Imed-Eddine
Inhibition of the ubiquitin-proteasome system induces stress granule formation.
Molecular biology of the cell 2007;18(7):2603-18.
2007: Zhu Aihua; Sun Hongmin; Raymond Richard M; Furie Barbara C; Furie Bruce; Bronstein Mila; Kaufman Randal J; Westrick Randal; Ginsburg David
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
Blood 2007;109(12):5270-5.
2007: Nagasawa Koji; Higashi Toshio; Hosokawa Nobuko; Kaufman Randal J; Nagata Kazuhiro
Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.
EMBO reports 2007;8(5):483-9.
2007: Costa-Mattioli Mauro; Gobert Delphine; Stern Elad; Gamache Karine; Colina Rodney; Cuello Claudio; Sossin Wayne; Kaufman Randal; Pelletier Jerry; Rosenblum Kobi; Krnjevic Kresimir; Lacaille Jean-Claude; Nader Karim; Sonenberg Nahum
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Cell 2007;129(1):195-206.
2007: Shang Jie; Gao Ningguo; Kaufman Randal J; Ron David; Harding Heather P; Lehrman Mark A
Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux.
The Journal of cell biology 2007;176(5):605-16.
2007: Vander Mierde Dirk; Scheuner Donalyn; Quintens Roel; Patel Rupali; Song Benbo; Tsukamoto Katsura; Beullens Monique; Kaufman Randal J; Bollen Mathieu; Schuit Frans C
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.
Endocrinology 2007;148(2):609-17.
2007: Kouroku Y; Fujita E; Tanida I; Ueno T; Isoai A; Kumagai H; Ogawa S; Kaufman R J; Kominami E; Momoi T
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
Cell death and differentiation 2007;14(2):230-9.
2006: Rutkowski D Thomas; Arnold Stacey M; Miller Corey N; Wu Jun; Li Jack; Gunnison Kathryn M; Mori Kazutoshi; Sadighi Akha Amir A; Raden David; Kaufman Randal J
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.
PLoS biology 2006;4(11):e374.
2006: Nyfeler Beat; Zhang Bin; Ginsburg David; Kaufman Randal J; Hauri Hans-Peter
Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.
Traffic (Copenhagen, Denmark) 2006;7(11):1473-81.
2006: Robert Francis; Kapp Lee D; Khan Shakila N; Acker Michael G; Kolitz Sarah; Kazemi Shirin; Kaufman Randal J; Merrick William C; Koromilas Antonis E; Lorsch Jon R; Pelletier Jerry
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability.
Molecular biology of the cell 2006;17(11):4632-44.
2006: Denoyelle Christophe; Abou-Rjaily George; Bezrookove Vladimir; Verhaegen Monique; Johnson Timothy M; Fullen Douglas R; Pointer Jenny N; Gruber Stephen B; Su Lyndon D; Nikiforov Mikhail A; Kaufman Randal J; Bastian Boris C; Soengas Maria S
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.
Nature cell biology 2006;8(10):1053-63.
2006: Dang Yongjun; Kedersha Nancy; Low Woon-Kai; Romo Daniel; Gorospe Myriam; Kaufman Randal; Anderson Paul; Liu Jun O
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.
The Journal of biological chemistry 2006;281(43):32870-8.
2006: Fribley Andrew M; Evenchik Benjamin; Zeng Qinghua; Park Bae Keun; Guan Jean Y; Zhang Honglai; Hale Timothy J; Soengas Maria S; Kaufman Randal J; Wang Cun-Yu
Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.
The Journal of biological chemistry 2006;281(42):31440-7.
2006: Mazroui Rachid; Sukarieh Rami; Bordeleau Marie-Eve; Kaufman Randal J; Northcote Peter; Tanaka Junichi; Gallouzi Imed; Pelletier Jerry
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.
Molecular biology of the cell 2006;17(10):4212-9.
2006: Zhou Jiahai; Liu Chuan Yin; Back Sung Hoon; Clark Robert L; Peisach Daniel; Xu Zhaohui; Kaufman Randal J
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14343-8.
2006: Scheuner Donalyn; Patel Rupali; Wang Feng; Lee Kuei; Kumar Kotlo; Wu Jun; Nilsson Anders; Karin Michael; Kaufman Randal J
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
The Journal of biological chemistry 2006;281(30):21458-68.
2006: Back Sung Hoon; Lee Kyungho; Vink Elizabeth; Kaufman Randal J
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.
The Journal of biological chemistry 2006;281(27):18691-706.
2006: Hu Ping; Han Zhang; Couvillon Anthony D; Kaufman Randal J; Exton John H
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression.
Molecular and cellular biology 2006;26(8):3071-84.
2006: Koritzinsky Marianne; Magagnin Michaël G; van den Beucken Twan; Seigneuric Renaud; Savelkouls Kim; Dostie Josée; Pyronnet Stéphane; Kaufman Randal J; Weppler Sherry A; Voncken Jan Willem; Lambin Philippe; Koumenis Constantinos; Sonenberg Nahum; Wouters Bradly G
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.
The EMBO journal 2006;25(5):1114-25.
2006: Zhang Bin; McGee Beth; Yamaoka Jennifer S; Guglielmone Hugo; Downes Katharine A; Minoldo Salvador; Jarchum Gustavo; Peyvandi Flora; de Bosch Norma B; Ruiz-Saez Arlette; Chatelain Bernard; Olpinski Marian; Bockenstedt Paula; Sperl Wolfgang; Kaufman Randal J; Nichols William C; Tuddenham Edward G D; Ginsburg David
Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.
Blood 2006;107(5):1903-7.
2006: Zhang Kezhong; Shen Xiaohua; Wu Jun; Sakaki Kenjiro; Saunders Thomas; Rutkowski D Thomas; Back Sung Hoon; Kaufman Randal J
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.
Cell 2006;124(3):587-99.
2006: Smith Jennifer A; Schmechel Stephen C; Raghavan Arvind; Abelson Michelle; Reilly Cavan; Katze Michael G; Kaufman Randal J; Bohjanen Paul R; Schiff Leslie A
Reovirus induces and benefits from an integrated cellular stress response.
Journal of virology 2006;80(4):2019-33.
2006: Oda Yukako; Okada Tetsuya; Yoshida Hiderou; Kaufman Randal J; Nagata Kazuhiro; Mori Kazutoshi
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.
The Journal of cell biology 2006;172(3):383-93.
2006: Zhang Kezhong; Kaufman Randal J
The unfolded protein response: a stress signaling pathway critical for health and disease.
Neurology 2006;66(2 Suppl 1):S102-9.
2005: Harding Heather P; Zhang Yuhong; Khersonsky Sonya; Marciniak Stefan; Scheuner Donalyn; Kaufman Randal J; Javitt Norman; Chang Young-Tae; Ron David
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.
Cell metabolism 2005;2(6):361-71.
2005: Molinari Maurizio; Galli Carmela; Vanoni Omar; Arnold Stacey M; Kaufman Randal J
Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence.
Molecular cell 2005;20(4):503-12.
2005: Bi Meixia; Naczki Christine; Koritzinsky Marianne; Fels Diane; Blais Jaime; Hu Nianping; Harding Heather; Novoa Isabelle; Varia Mahesh; Raleigh James; Scheuner Donalyn; Kaufman Randal J; Bell John; Ron David; Wouters Bradly G; Koumenis Constantinos
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.
The EMBO journal 2005;24(19):3470-81.
2005: Shen Xiaohua; Ellis Ronald E; Sakaki Kenjiro; Kaufman Randal J
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
PLoS genetics 2005;1(3):e37.
2005: McInerney Gerald M; Kedersha Nancy L; Kaufman Randal J; Anderson Paul; Liljeström Peter
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation.
Molecular biology of the cell 2005;16(8):3753-63.
2005: Scheuner Donalyn; Vander Mierde Dirk; Song Benbo; Flamez Daisy; Creemers John W M; Tsukamoto Katsura; Ribick Mark; Schuit Frans C; Kaufman Randal J
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.
Nature medicine 2005;11(7):757-64.
2005: Zhang Bin; Kaufman Randal J; Ginsburg David
LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway.
The Journal of biological chemistry 2005;280(27):25881-6.
2005: Kedersha Nancy; Stoecklin Georg; Ayodele Maranatha; Yacono Patrick; Lykke-Andersen Jens; Fritzler Marvin J; Scheuner Donalyn; Kaufman Randal J; Golan David E; Anderson Paul
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.
The Journal of cell biology 2005;169(6):871-84.
2005: Back Sung Hoon; Schröder Martin; Lee Kyungho; Zhang Kezhong; Kaufman Randal J
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1.
Methods (San Diego, Calif.) 2005;35(4):395-416.
2005: McEwen Edward; Kedersha Nancy; Song Benbo; Scheuner Donalyn; Gilks Natalie; Han Anping; Chen Jane-Jane; Anderson Paul; Kaufman Randal J
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.
The Journal of biological chemistry 2005;280(17):16925-33.
2005: Boyce Michael; Bryant Kevin F; Jousse Céline; Long Kai; Harding Heather P; Scheuner Donalyn; Kaufman Randal J; Ma Dawei; Coen Donald M; Ron David; Yuan Junying
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 2005;307(5711):935-9.
2005: Fernandez James; Yaman Ibrahim; Huang Charles; Liu Haiyan; Lopez Alex B; Komar Anton A; Caprara Mark G; Merrick William C; Snider Martin D; Kaufman Randal J; Lamers Wouter H; Hatzoglou Maria
Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.
Molecular cell 2005;17(3):405-16.
2005: Zhang Kezhong; Wong Hetty N; Song Benbo; Miller Corey N; Scheuner Donalyn; Kaufman Randal J
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
The Journal of clinical investigation 2005;115(2):268-81.
2004: Deng Jing; Lu Phoebe D; Zhang Yuhong; Scheuner Donalyn; Kaufman Randal J; Sonenberg Nahum; Harding Heather P; Ron David
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.
Molecular and cellular biology 2004;24(23):10161-8.
2004: Yamamoto Keisuke; Yoshida Hiderou; Kokame Koichi; Kaufman Randal J; Mori Kazutoshi
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II.
Journal of biochemistry 2004;136(3):343-50.
2004: Shen Xiaohua; Zhang Kezhong; Kaufman Randal J
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum.
Journal of chemical neuroanatomy 2004;28(1-2):79-92.
2004: Nguyên Duc Thang; Kebache Sem; Fazel Ali; Wong Hetty N; Jenna Sarah; Emadali Anouk; Lee Eun-Hye; Bergeron John J M; Kaufman Randal J; Larose Louise; Chevet Eric
Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress.
Molecular biology of the cell 2004;15(9):4248-60.
2004: Wu Shiyong; Kaufman Randal J
trans-Autophosphorylation by the isolated kinase domain is not sufficient for dimerization or activation of the dsRNA-activated protein kinase PKR.
Biochemistry 2004;43(34):11027-34.
2004: Wu Shiyong; Tan Mingjia; Hu Yuanyuan; Wang Ju-Lin; Scheuner Donalyn; Kaufman Randal J
Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis.
The Journal of biological chemistry 2004;279(33):34898-902.
2004: Ye Peiqing; Thompson Arthur R; Sarkar Rita; Shen Zhenping; Lillicrap David P; Kaufman Randal J; Ochs Hans D; Rawlings David J; Miao Carol H
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(1):117-26.
2004: Schröder Martin; Clark Robert; Liu Chuan Yin; Kaufman Randal J
The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase.
The EMBO journal 2004;23(11):2281-92.
2004: Zhang Kezhong; Kaufman Randal J
Signaling the unfolded protein response from the endoplasmic reticulum.
The Journal of biological chemistry 2004;279(25):25935-8.
2004: Miao Hongzhi Z; Sirachainan Nongnuch; Palmer Lisa; Kucab Phillip; Cunningham Michael A; Kaufman Randal J; Pipe Steven W
Bioengineering of coagulation factor VIII for improved secretion.
Blood 2004;103(9):3412-9.
2004: Tardif Keith D; Mori Kazutoshi; Kaufman Randal J; Siddiqui Aleem
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.
The Journal of biological chemistry 2004;279(17):17158-64.
2004: Hsu Li-Chung; Park Jin Mo; Zhang Kezhong; Luo Jun-Li; Maeda Shin; Kaufman Randal J; Eckmann Lars; Guiney Donald G; Karin Michael
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.
Nature 2004;428(6980):341-5.
2004: Kaufman Randal J
Regulation of mRNA translation by protein folding in the endoplasmic reticulum.
Trends in biochemical sciences 2004;29(3):152-8.
2004: Rutkowski D Thomas; Kaufman Randal J
A trip to the ER: coping with stress.
Trends in cell biology 2004;14(1):20-8.
2004: Lu Phoebe D; Jousse Céline; Marciniak Stefan J; Zhang Yuhong; Novoa Isabel; Scheuner Donalyn; Kaufman Randal J; Ron David; Harding Heather P
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.
The EMBO journal 2004;23(1):169-79.
2004: Wiederkehr C; Basavaraj R; Sarrauste de Menthière C; Hermida L; Koch R; Schlecht U; Amon A; Brachat S; Breitenbach M; Briza P; Caburet S; Cherry M; Davis R; Deutschbauer A; Dickinson H G; Dumitrescu T; Fellous M; Goldman A; Grootegoed J A; Hawley R; Ishii R; Jégou B; Kaufman R J; Klein F; Lamb N; Maro B; Nasmyth K; Nicolas A; Orr-Weaver T; Philippsen P; Pineau C; Rabitsch K P; Reinke V; Roest H; Saunders W; Schröder M; Schedl T; Siep M; Villeneuve A; Wolgemuth D J; Yamamoto M; Zickler D; Esposito R E; Primig M
GermOnline, a cross-species community knowledgebase on germ cell differentiation.
Nucleic acids research 2004;32(Database issue):D560-7.
2003: Scheuner Donalyn; Gromeier Matthias; Davies Monique V; Dorner Andrew J; Song Benbo; Patel Rupali V; Wimmer Eckard J; McLendon Roger E; Kaufman Randal J
The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.
Virology 2003;317(2):263-74.
2003: Aparna Gunda; Bhuyan Abani K; Sahdev Sudhir; Hasnain Seyed E; Kaufman Randal J; Ramaiah Kolluru V A
Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation.
Biochemistry 2003;42(51):15352-60.
2003: Kaufman R J
Good things come in small packages for hemophilia.
Journal of thrombosis and haemostasis : JTH 2003;1(12):2472-3.
2003: Cunningham M A; Pipe S W; Zhang B; Hauri H-P; Ginsburg D; Kaufman R J
LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII.
Journal of thrombosis and haemostasis : JTH 2003;1(11):2360-7.
2003: Cullinan Sara B; Zhang Donna; Hannink Mark; Arvisais Edward; Kaufman Randal J; Diehl J Alan
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.
Molecular and cellular biology 2003;23(20):7198-209.
2003: Arnold Stacey M; Kaufman Randal J
The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.
The Journal of biological chemistry 2003;278(44):43320-8.
2003: Jiang Hao-Yuan; Wek Sheree A; McGrath Barbara C; Scheuner Donalyn; Kaufman Randal J; Cavener Douglas R; Wek Ronald C
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Molecular and cellular biology 2003;23(16):5651-63.
2003: Schröder Martin; Clark Robert; Kaufman Randal J
IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast.
Molecular microbiology 2003;49(3):591-606.
2003: Hossain Gazi S; van Thienen Johannes V; Werstuck Geoff H; Zhou Ji; Sood Sudesh K; Dickhout Jeffrey G; de Koning A B Lawrence; Tang Damu; Wu Dongcheng; Falk Erling; Poddar Ranjana; Jacobsen Donald W; Zhang Kezhong; Kaufman Randal J; Austin Richard C
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia.
The Journal of biological chemistry 2003;278(32):30317-27.
2003: Komiyama Tomoko; VanderLugt Bryan; Fugère Martin; Day Robert; Kaufman Randal J; Fuller Robert S
Optimization of protease-inhibitor interactions by randomizing adventitious contacts.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8205-10.
2003: Zhang Bin; Cunningham Michael A; Nichols William C; Bernat John A; Seligsohn Uri; Pipe Steven W; McVey John H; Schulte-Overberg Ursula; de Bosch Norma B; Ruiz-Saez Arlette; White Gilbert C; Tuddenham E G D; Kaufman Randal J; Ginsburg David
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
Nature genetics 2003;34(2):220-5.
2003: Reddy Ramachandra K; Mao Changhui; Baumeister Peter; Austin Richard C; Kaufman Randal J; Lee Amy S
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.
The Journal of biological chemistry 2003;278(23):20915-24.
2003: Yaman Ibrahim; Fernandez James; Liu Haiyan; Caprara Mark; Komar Anton A; Koromilas Antonis E; Zhou Lingyin; Snider Martin D; Scheuner Donalyn; Kaufman Randal J; Hatzoglou Maria
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.
Cell 2003;113(4):519-31.
2003: Knee Rai; Ahsan Irfan; Mesaeli Nasrin; Kaufman Randal J; Michalak Marek
Compromised calnexin function in calreticulin-deficient cells.
Biochemical and biophysical research communications 2003;304(4):661-6.
2003: Liu Chuan Yin; Kaufman Randal J
The unfolded protein response.
Journal of cell science 2003;116(Pt 10):1861-2.
2003: Liu Chuan Yin; Xu Zhaohui; Kaufman Randal J
Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.
The Journal of biological chemistry 2003;278(20):17680-7.
2003: Rutkowski D Thomas; Kaufman Randal J
All roads lead to ATF4.
Developmental cell 2003;4(4):442-4.
2003: Ward Stephen L; Scheuner Donalyn; Poppers Jeremy; Kaufman Randal J; Mohr Ian; Leib David A
In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.
Journal of virology 2003;77(8):4626-34.
2003: Lee Kyungho; Neigeborn Lenore; Kaufman Randal J
The unfolded protein response is required for haploid tolerance in yeast.
The Journal of biological chemistry 2003;278(14):11818-27.
2003: Yoshida Hiderou; Matsui Toshie; Hosokawa Nobuko; Kaufman Randal J; Nagata Kazuhiro; Mori Kazutoshi
A time-dependent phase shift in the mammalian unfolded protein response.
Developmental cell 2003;4(2):265-71.
2002: Kingston Robert E; Kaufman Randal J; Bebbington C R; Rolfe M R
Amplification using CHO cell expression vectors.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2002;Chapter 16():Unit 16.23.
2002: Kaufman Randal J
Orchestrating the unfolded protein response in health and disease.
The Journal of clinical investigation 2002;110(10):1389-98.
2002: Hakeos William H; Miao Hongzhi; Sirachainan Nongnuch; Kemball-Cook Geoffrey; Saenko Evgueni L; Kaufman Randal J; Pipe Steven W
Hemophilia A mutations within the factor VIII A2-A3 subunit interface destabilize factor VIIIa and cause one-stage/two-stage activity discrepancy.
Thrombosis and haemostasis 2002;88(5):781-7.
2002: Deng Jing; Harding Heather P; Raught Brian; Gingras Anne-Claude; Berlanga Juan Jose; Scheuner Donalyn; Kaufman Randal J; Ron David; Sonenberg Nahum
Activation of GCN2 in UV-irradiated cells inhibits translation.
Current biology : CB 2002;12(15):1279-86.
2002: Kaufman Randal J; Scheuner Donalyn; Schröder Martin; Shen Xiaohua; Lee Kyungho; Liu Chuan Yin; Arnold Stacey M
The unfolded protein response in nutrient sensing and differentiation.
Nature reviews. Molecular cell biology 2002;3(6):411-21.
2002: Liu Chuan Yin; Wong Hetty N; Schauerte Joseph A; Kaufman Randal J
The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain.
The Journal of biological chemistry 2002;277(21):18346-56.
2002: Wu Shiyong; Hu Yuanyuan; Wang Ju-Lin; Chatterjee Madhumita; Shi Yuguang; Kaufman Randal J
Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum.
The Journal of biological chemistry 2002;277(20):18077-83.
2002: Lee Kyungho; Tirasophon Witoon; Shen Xiaohua; Michalak Marek; Prywes Ron; Okada Tetsuya; Yoshida Hiderou; Mori Kazutoshi; Kaufman Randal J
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Genes & development 2002;16(4):452-66.
2002: Gilbert Gary E; Kaufman Randal J; Arena Andrew A; Miao Hongzhi; Pipe Steven W
Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs.
The Journal of biological chemistry 2002;277(8):6374-81.
2002: Tallóczy Zsolt; Jiang Wenxia; Virgin Herbert W; Leib David A; Scheuner Donalyn; Kaufman Randal J; Eskelinen Eeva-Liisa; Levine Beth
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):190-5.
2001: Shen X; Ellis R E; Lee K; Liu C Y; Yang K; Solomon A; Yoshida H; Morimoto R; Kurnit D M; Mori K; Kaufman R J
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
Cell 2001;107(7):893-903.
2001: Zhang C; Cai Y; Adachi M T; Oshiro S; Aso T; Kaufman R J; Kitajima S
Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.
The Journal of biological chemistry 2001;276(38):35867-74.
2001: Scarim A L; Arnush M; Blair L A; Concepcion J; Heitmeier M R; Scheuner D; Kaufman R J; Ryerse J; Buller R M; Corbett J A
Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.
The American journal of pathology 2001;159(1):273-83.
2001: Scheuner D; Song B; McEwen E; Liu C; Laybutt R; Gillespie P; Saunders T; Bonner-Weir S; Kaufman R J
Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
Molecular cell 2001;7(6):1165-76.
2001: Pipe S W; Saenko E L; Eickhorst A N; Kemball-Cook G; Kaufman R J
Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa.
Blood 2001;97(3):685-91.
2000: Schröder M; Chang J S; Kaufman R J
The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast.
Genes & development 2000;14(23):2962-75.
2000: Tirasophon W; Lee K; Callaghan B; Welihinda A; Kaufman R J
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response.
Genes & development 2000;14(21):2725-36.
2000: Sudhakar A; Ramachandran A; Ghosh S; Hasnain S E; Kaufman R J; Ramaiah K V
Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B.
Biochemistry 2000;39(42):12929-38.
2000: Wang Y; Shen J; Arenzana N; Tirasophon W; Kaufman R J; Prywes R
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.
The Journal of biological chemistry 2000;275(35):27013-20.
2000: Liu C Y; Schröder M; Kaufman R J
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.
The Journal of biological chemistry 2000;275(32):24881-5.
2000: Maggi L B; Heitmeier M R; Scheuner D; Kaufman R J; Buller R M; Corbett J A
Potential role of PKR in double-stranded RNA-induced macrophage activation.
The EMBO journal 2000;19(14):3630-8.
2000: Arnold S M; Fessler L I; Fessler J H; Kaufman R J
Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.
Biochemistry 2000;39(9):2149-63.
2000: Tagliavacca L; Wang Q; Kaufman R J
ATP-dependent dissociation of non-disulfide-linked aggregates of coagulation factor VIII is a rate-limiting step for secretion.
Biochemistry 2000;39(8):1973-81.
2000: Welihinda A A; Tirasophon W; Kaufman R J
The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo.
The Journal of biological chemistry 2000;275(5):3377-81.
1999: Niwa M; Sidrauski C; Kaufman R J; Walter P
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response.
Cell 1999;99(7):691-702.
1999: Sudhakar A; Krishnamoorthy T; Jain A; Chatterjee U; Hasnain S E; Kaufman R J; Ramaiah K V
Serine 48 in initiation factor 2 alpha (eIF2 alpha) is required for high-affinity interaction between eIF2 alpha(P) and eIF2B.
Biochemistry 1999;38(46):15398-405.
1999: Moussalli M; Pipe S W; Hauri H P; Nichols W C; Ginsburg D; Kaufman R J
Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII.
The Journal of biological chemistry 1999;274(46):32539-42.
1999: Foti D M; Welihinda A; Kaufman R J; Lee A S
Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1.
The Journal of biological chemistry 1999;274(43):30402-9.
1999: Kaufman R J
Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11693-5.
1999: Kaufman R J
Advances toward gene therapy for hemophilia at the millennium.
Human gene therapy 1999;10(13):2091-107.
1999: Kaufman R J
Correction of genetic disease by making sense from nonsense.
The Journal of clinical investigation 1999;104(4):367-8.
1999: Kaufman R J
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.
Genes & development 1999;13(10):1211-33.
1999: Thorelli E; Kaufman R J; Dahlbäck B
Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V.
Blood 1999;93(8):2552-8.
1999: Nichols W C; Terry V H; Wheatley M A; Yang A; Zivelin A; Ciavarella N; Stefanile C; Matsushita T; Saito H; de Bosch N B; Ruiz-Saez A; Torres A; Thompson A R; Feinstein D I; White G C; Negrier C; Vinciguerra C; Aktan M; Kaufman R J; Ginsburg D; Seligsohn U
ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families.
Blood 1999;93(7):2261-6.
1999: Heeb M J; Rehemtulla A; Moussalli M; Kojima Y; Kaufman R J
Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.
European journal of biochemistry / FEBS 1999;260(1):64-75.
1999: DeGracia D J; Adamczyk S; Folbe A J; Konkoly L L; Pittman J E; Neumar R W; Sullivan J M; Scheuner D; Kaufman R J; White B C; Krause G S
Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion.
Experimental neurology 1999;155(2):221-7.
1999: Connelly S; Andrews J L; Gallo-Penn A M; Tagliavacca L; Kaufman R J; Kaleko M
Evaluation of an adenoviral vector encoding full-length human factor VIII in hemophiliac mice.
Thrombosis and haemostasis 1999;81(2):234-9.
1999: Kumar K U; Srivastava S P; Kaufman R J
Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18.
Molecular and cellular biology 1999;19(2):1116-25.
1999: Kaufman R J
Molecular chaperones and the heat shock response. Sponsored by Cold Spring Harbor Laboratory, 6-10 May 1998.
Biochimica et biophysica acta 1999;1423(1):R13-27.
1999: Kaufman R J; Dorner A J; Fass D N
von Willebrand factor elevates plasma factor VIII without induction of factor VIII messenger RNA in the liver.
Blood 1999;93(1):193-7.
1999: Pipe S W; Eickhorst A N; McKinley S H; Saenko E L; Kaufman R J
Mild hemophilia A caused by increased rate of factor VIII A2 subunit dissociation: evidence for nonproteolytic inactivation of factor VIIIa in vivo.
Blood 1999;93(1):176-83.
1999: Welihinda A A; Tirasophon W; Kaufman R J
The cellular response to protein misfolding in the endoplasmic reticulum.
Gene expression 1999;7(4-6):293-300.
1998: Wu S; Kumar K U; Kaufman R J
Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR).
Biochemistry 1998;37(39):13816-26.
1998: Ginsburg D; Nichols W C; Zivelin A; Kaufman R J; Seligsohn U
Combined factors V and VIII deficiency--the solution.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):677-82.
1998: Kaufman R J; Pipe S W
Can we improve on nature? "Super molecules" of factor VIII.
Haemophilia : the official journal of the World Federation of Hemophilia 1998;4(4):370-9.
1998: Thorelli E; Kaufman R J; Dahlbäck B
Cleavage requirements of factor V in tissue-factor induced thrombin generation.
Thrombosis and haemostasis 1998;80(1):92-8.
1998: Bendetowicz A V; Morris J A; Wise R J; Gilbert G E; Kaufman R J
Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers.
Blood 1998;92(2):529-38.
1998: Kaufman R J
Post-translational modifications required for coagulation factor secretion and function.
Thrombosis and haemostasis 1998;79(6):1068-79.
1998: Tirasophon W; Welihinda A A; Kaufman R J
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.
Genes & development 1998;12(12):1812-24.
1998: Thorelli E; Kaufman R J; Dahlbäck B
The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V.
The Journal of biological chemistry 1998;273(26):16140-5.
1998: Yang T L; Cui J; Rehumtulla A; Yang A; Moussalli M; Kaufman R J; Ginsburg D
The structure and function of murine factor V and its inactivation by protein C.
Blood 1998;91(12):4593-9.
1998: Nichols W C; Seligsohn U; Zivelin A; Terry V H; Hertel C E; Wheatley M A; Moussalli M J; Hauri H P; Ciavarella N; Kaufman R J; Ginsburg D
Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII.
Cell 1998;93(1):61-70.
1998: Welihinda A A; Tirasophon W; Green S R; Kaufman R J
Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.
Molecular and cellular biology 1998;18(4):1967-77.
1998: Pipe S W; Morris J A; Shah J; Kaufman R J
Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.
The Journal of biological chemistry 1998;273(14):8537-44.
1998: Amano K; Michnick D A; Moussalli M; Kaufman R J
Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.
Thrombosis and haemostasis 1998;79(3):557-63.
1998: Rosenberg J B; Foster P A; Kaufman R J; Vokac E A; Moussalli M; Kroner P A; Montgomery R R
Intracellular trafficking of factor VIII to von Willebrand factor storage granules.
The Journal of clinical investigation 1998;101(3):613-24.
1998: Srivastava S P; Kumar K U; Kaufman R J
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase.
The Journal of biological chemistry 1998;273(4):2416-23.
1998: Amano K; Sarkar R; Pemberton S; Kemball-Cook G; Kazazian H H; Kaufman R J
The molecular basis for cross-reacting material-positive hemophilia A due to missense mutations within the A2-domain of factor VIII.
Blood 1998;91(2):538-48.
1997: Kaufman R J; Pipe S W; Tagliavacca L; Swaroop M; Moussalli M
Biosynthesis, assembly and secretion of coagulation factor VIII.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8 Suppl 2():S3-14.
1997: Pipe S W; Kaufman R J
Characterization of a genetically engineered inactivation-resistant coagulation factor VIIIa.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11851-6.
1997: Tagliavacca L; Moon N; Dunham W R; Kaufman R J
Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII.
The Journal of biological chemistry 1997;272(43):27428-34.
1997: Swaroop M; Moussalli M; Pipe S W; Kaufman R J
Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII.
The Journal of biological chemistry 1997;272(39):24121-4.
1997: Thorelli E; Kaufman R J; Dahlbäck B
Cleavage requirements for activation of factor V by factor Xa.
European journal of biochemistry / FEBS 1997;247(1):12-20.
1997: Kaufman R J
DNA transfection to study translational control in mammalian cells.
Methods (San Diego, Calif.) 1997;11(4):361-70.
1997: Welihinda A A; Tirasophon W; Green S R; Kaufman R J
Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4289-94.
1997: Nichols W C; Seligsohn U; Zivelin A; Terry V H; Arnold N D; Siemieniak D R; Kaufman R J; Ginsburg D
Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping.
The Journal of clinical investigation 1997;99(4):596-601.
1997: Morris J A; Dorner A J; Edwards C A; Hendershot L M; Kaufman R J
Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins.
The Journal of biological chemistry 1997;272(7):4327-34.
1997: Wu S; Kaufman R J
A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.
The Journal of biological chemistry 1997;272(2):1291-6.
1997: Kaufman R J
Overview of vector design for mammalian gene expression.
Methods in molecular biology (Clifton, N.J.) 1997;62():287-300.
1996: Mohlke K L; Nichols W C; Rehemtulla A; Kaufman R J; Fagerström H M; Ritvanen K L; Kekomaki R; Ginsburg D
A common frameshift mutation in von Willebrand factor does not alter mRNA stability but interferes with normal propeptide processing.
British journal of haematology 1996;95(1):184-91.
1996: Pipe S W; Kaufman R J
Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins.
The Journal of biological chemistry 1996;271(41):25671-6.
1996: Brostrom C O; Prostko C R; Kaufman R J; Brostrom M A
Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha kinase.
The Journal of biological chemistry 1996;271(40):24995-5002.
1996: Nichols W C; Amano K; Cacheris P M; Figueiredo M S; Michaelides K; Schwaab R; Hoyer L; Kaufman R J; Ginsburg D
Moderation of hemophilia A phenotype by the factor V R506Q mutation.
Blood 1996;88(4):1183-7.
1996: Welihinda A A; Kaufman R J
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation.
The Journal of biological chemistry 1996;271(30):18181-7.
1996: Wu S; Rehemtulla A; Gupta N K; Kaufman R J
A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells.
Biochemistry 1996;35(25):8275-80.
1996: Fay P J; Beattie T L; Regan L M; O'Brien L M; Kaufman R J
Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis.
The Journal of biological chemistry 1996;271(11):6027-32.
1996: Wu S; Kaufman R J
Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).
The Journal of biological chemistry 1996;271(3):1756-63.
1996: Israel D I; Nove J; Kerns K M; Kaufman R J; Rosen V; Cox K A; Wozney J M
Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo.
Growth factors (Chur, Switzerland) 1996;13(3-4):291-300.
1995: Drews R; Paleyanda R K; Lee T K; Chang R R; Rehemtulla A; Kaufman R J; Drohan W N; Lubon H
Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10462-6.
1995: Marquette K A; Pittman D D; Kaufman R J
The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain.
Blood 1995;86(8):3026-34.
1995: Srivastava S P; Davies M V; Kaufman R J
Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis.
The Journal of biological chemistry 1995;270(28):16619-24.
1995: Marquette K A; Pittman D D; Kaufman R J
A 110-amino acid region within the A1-domain of coagulation factor VIII inhibits secretion from mammalian cells.
The Journal of biological chemistry 1995;270(17):10297-303.
1994: Pittman D D; Marquette K A; Kaufman R J
Role of the B domain for factor VIII and factor V expression and function.
Blood 1994;84(12):4214-25.
1994: Kaufman R J
Control of gene expression at the level of translation initiation.
Current opinion in biotechnology 1994;5(5):550-7.
1994: Kaufman R J; Swaroop M; Murtha-Riel P
Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells.
Biochemistry 1994;33(33):9813-9.
1994: Michnick D A; Pittman D D; Wise R J; Kaufman R J
Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.
The Journal of biological chemistry 1994;269(31):20095-102.
1994: Ramaiah K V; Davies M V; Chen J J; Kaufman R J
Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation.
Molecular and cellular biology 1994;14(7):4546-53.
1994: Pittman D D; Tomkinson K N; Michnick D; Selighsohn U; Kaufman R J
Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Biochemistry 1994;33(22):6952-9.
1994: Pittman D D; Tomkinson K N; Kaufman R J
Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.
The Journal of biological chemistry 1994;269(25):17329-37.
1994: Dorner A J; Kaufman R J
The levels of endoplasmic reticulum proteins and ATP affect folding and secretion of selective proteins.
Biologicals : journal of the International Association of Biological Standardization 1994;22(2):103-12.
1994: Park H; Davies M V; Langland J O; Chang H W; Nam Y S; Tartaglia J; Paoletti E; Jacobs B L; Kaufman R J; Venkatesan S
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4713-7.
1993: Rehemtulla A; Barr P J; Rhodes C J; Kaufman R J
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
Biochemistry 1993;32(43):11586-90.
1993: Roth D A; Rehemtulla A; Kaufman R J; Walsh C T; Furie B; Furie B C
Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8372-6.
1993: Murtha-Riel P; Davies M V; Scherer B J; Choi S Y; Hershey J W; Kaufman R J
Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis.
The Journal of biological chemistry 1993;268(17):12946-51.
1993: Kaufman R J; Murtha-Riel P; Pittman D D; Davies M V
Characterization of wild-type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells.
The Journal of biological chemistry 1993;268(16):11902-9.
1993: Pittman D D; Alderman E M; Tomkinson K N; Wang J H; Giles A R; Kaufman R J
Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII.
Blood 1993;81(11):2925-35.
1993: Lynch C M; Israel D I; Kaufman R J; Miller A D
Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production.
Human gene therapy 1993;4(3):259-72.
1993: Clemens M J; Hershey J W; Hovanessian A C; Jacobs B C; Katze M G; Kaufman R J; Lengyel P; Samuel C E; Sen G C; Williams B R
PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon.
Journal of interferon research 1993;13(3):241.
1993: Rehemtulla A; Roth D A; Wasley L C; Kuliopulos A; Walsh C T; Furie B; Furie B C; Kaufman R J
In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4611-5.
1993: Israel D I; Kaufman R J
Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/glucocorticoid receptor protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4290-4.
1993: Wasley L C; Rehemtulla A; Bristol J A; Kaufman R J
PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway.
The Journal of biological chemistry 1993;268(12):8458-65.
1993: Davies M V; Chang H W; Jacobs B L; Kaufman R J
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.
Journal of virology 1993;67(3):1688-92.
1992: Kaufman R J
Expression and structure-function properties of recombinant factor VIII.
Transfusion medicine reviews 1992;6(4):235-46.
1992: Rehemtulla A; Dorner A J; Kaufman R J
Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8235-9.
1992: Rehemtulla A; Kaufman R J
Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes.
Blood 1992;79(9):2349-55.
1992: Pittman D D; Wang J H; Kaufman R J
Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII.
Biochemistry 1992;31(13):3315-25.
1992: Dorner A J; Wasley L C; Kaufman R J
Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.
The EMBO journal 1992;11(4):1563-71.
1992: Davies M V; Elroy-Stein O; Jagus R; Moss B; Kaufman R J
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
Journal of virology 1992;66(4):1943-50.
1992: Davies M V; Kaufman R J
The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation.
Journal of virology 1992;66(4):1924-32.
1992: Koo H M; Brown A M; Kaufman R J; Prorock C M; Ron Y; Dougherty J P
A spleen necrosis virus-based retroviral vector which expresses two genes from a dicistronic mRNA.
Virology 1992;186(2):669-75.
1992: Pittman D D; Millenson M; Marquette K; Bauer K; Kaufman R J
A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage.
Blood 1992;79(2):389-97.
1992: Choi S Y; Scherer B J; Schnier J; Davies M V; Kaufman R J; Hershey J W
Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2.
The Journal of biological chemistry 1992;267(1):286-93.
1992: Kaufman R J
Biological regulation of factor VIII activity.
Annual review of medicine 1992;43():325-39.
1992: Israel D I; Nove J; Kerns K M; Moutsatsos I K; Kaufman R J
Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells.
Growth factors (Chur, Switzerland) 1992;7(2):139-50.
1991: Wise R J; Dorner A J; Krane M; Pittman D D; Kaufman R J
The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.
The Journal of biological chemistry 1991;266(32):21948-55.
1991: Kaufman R J
Insight into the structure, function, and biosynthesis of factor VIII through recombinant DNA technology.
Annals of hematology 1991;63(3):155-65.
1991: Nesheim M; Pittman D D; Giles A R; Fass D N; Wang J H; Slonosky D; Kaufman R J
The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets.
The Journal of biological chemistry 1991;266(27):17815-20.
1991: Dorner A J; Bonneville F; Kriz R; Kelleher K; Bean K; Kaufman R J
Molecular cloning and characterization of a complete Chinese hamster provirus related to intracisternal A particle genomes.
Journal of virology 1991;65(9):4713-9.
1991: Wood C R; Morris G E; Alderman E M; Fouser L; Kaufman R J
An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8006-10.
1991: Davies M V; Pelletier J; Meerovitch K; Sonenberg N; Kaufman R J
The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation.
The Journal of biological chemistry 1991;266(22):14714-20.
1991: Kaufman R J; Davies M V; Wasley L C; Michnick D
Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus.
Nucleic acids research 1991;19(16):4485-90.
1991: Wasley L C; Timony G; Murtha P; Stoudemire J; Dorner A J; Caro J; Krieger M; Kaufman R J
The importance of N- and O-linked oligosaccharides for the biosynthesis and in vitro and in vivo biologic activities of erythropoietin.
Blood 1991;77(12):2624-32.
1991: Messier T L; Pittman D D; Long G L; Kaufman R J; Church W R
Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.
Gene 1991;99(2):291-4.
1990: Dorner A J; Wasley L C; Raney P; Haugejorden S; Green M; Kaufman R J
The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.
The Journal of biological chemistry 1990;265(35):22029-34.
1990: Wise R J; Barr P J; Wong P A; Kiefer M C; Brake A J; Kaufman R J
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9378-82.
1990: Lum L S; Sultzman L A; Kaufman R J; Linzer D I; Wu B J
A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter.
Molecular and cellular biology 1990;10(12):6709-17.
1990: Kaufman R J
Mammalian recombinant proteins: structure, function and immunological analysis.
Current opinion in biotechnology 1990;1(2):141-50.
1990: Wood C R; Dorner A J; Morris G E; Alderman E M; Wilson D; O'Hara R M; Kaufman R J
High level synthesis of immunoglobulins in Chinese hamster ovary cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):3011-6.
1990: Dorner A J; Wasley L C; Kaufman R J
Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7429-32.
1990: Milburn S C; Hershey J W; Davies M V; Kelleher K; Kaufman R J
Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.
The EMBO journal 1990;9(9):2783-90.
1990: Israel D I; Kaufman R J
Retroviral-mediated transfer and amplification of a functional human factor VIII gene.
Blood 1990;75(5):1074-80.
1990: Kaufman R J
Control of translation initiation in mammalian cells.
Genetic engineering 1990;12():243-73.
1989: Davies M V; Furtado M; Hershey J W; Thimmappaya B; Kaufman R J
Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9163-7.
1989: Dorner A J; Wasley L C; Kaufman R J
Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells.
The Journal of biological chemistry 1989;264(34):20602-7.
1989: Smit-McBride Z; Schnier J; Kaufman R J; Hershey J W
Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein.
The Journal of biological chemistry 1989;264(31):18527-30.
1989: Israel D I; Kaufman R J
Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptor.
Nucleic acids research 1989;17(12):4589-604.
1989: Derian C K; VanDusen W; Przysiecki C T; Walsh P N; Berkner K L; Kaufman R J; Friedman P A
Inhibitors of 2-ketoglutarate-dependent dioxygenases block aspartyl beta-hydroxylation of recombinant human factor IX in several mammalian expression systems.
The Journal of biological chemistry 1989;264(12):6615-8.
1989: Jang S K; Davies M V; Kaufman R J; Wimmer E
Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo.
Journal of virology 1989;63(4):1651-60.
1989: Pittman D D; Kaufman R J
Structure-function relationships of factor VIII elucidated through recombinant DNA technology.
Thrombosis and haemostasis 1989;61(2):161-5.
1989: Kaufman R J; Davies M V; Pathak V K; Hershey J W
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.
Molecular and cellular biology 1989;9(3):946-58.
1989: Kaufman R J; Wasley L C; Davies M V; Wise R J; Israel D I; Dorner A J
Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.
Molecular and cellular biology 1989;9(3):1233-42.
1988: Nesheim M E; Pittman D D; Wang J H; Slonosky D; Giles A R; Kaufman R J
The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets.
The Journal of biological chemistry 1988;263(31):16467-70.
1988: Dorner A J; Krane M G; Kaufman R J
Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells.
Molecular and cellular biology 1988;8(10):4063-70.
1988: Kaufman R J; Wasley L C; Dorner A J
Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.
The Journal of biological chemistry 1988;263(13):6352-62.
1988: Pittman D D; Kaufman R J
Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII).
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2429-33.
1988: Wise R J; Pittman D D; Handin R I; Kaufman R J; Orkin S H
The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers.
Cell 1988;52(2):229-36.
1987: Dorner A J; Bole D G; Kaufman R J
The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins.
The Journal of cell biology 1987;105(6 Pt 1):2665-74.
1987: Oprian D D; Molday R S; Kaufman R J; Khorana H G
Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8874-8.
1987: Nielsen O J; Schuster S J; Kaufman R; Erslev A J; Caro J
Regulation of erythropoietin production in a human hepatoblastoma cell line.
Blood 1987;70(6):1904-9.
1987: Wasley L C; Atha D H; Bauer K A; Kaufman R J
Expression and characterization of human antithrombin III synthesized in mammalian cells.
The Journal of biological chemistry 1987;262(30):14766-72.
1987: Jenny R J; Pittman D D; Toole J J; Kriz R W; Aldape R A; Hewick R M; Kaufman R J; Mann K G
Complete cDNA and derived amino acid sequence of human factor V.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(14):4846-50.
1987: Kaufman R J; Murtha P
Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells.
Molecular and cellular biology 1987;7(4):1568-71.
1987: Wong G G; Temple P A; Leary A C; Witek-Giannotti J S; Yang Y C; Ciarletta A B; Chung M; Murtha P; Kriz R; Kaufman R J
Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
Science (New York, N.Y.) 1987;235(4795):1504-8.
1987: Kaufman R J; Murtha P; Davies M V
Translational efficiency of polycistronic mRNAs and their utilization to express heterologous genes in mammalian cells.
The EMBO journal 1987;6(1):187-93.
1987: Ting J; Wooden S K; Kriz R; Kelleher K; Kaufman R J; Lee A S
The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat.
Gene 1987;55(1):147-52.
1986: Bonthron D T; Handin R I; Kaufman R J; Wasley L C; Orr E C; Mitsock L M; Ewenstein B; Loscalzo J; Ginsburg D; Orkin S H
Structure of pre-pro-von Willebrand factor and its expression in heterologous cells.
Nature 1986;324(6094):270-3.
1986: Toole J J; Pittman D D; Orr E C; Murtha P; Wasley L C; Kaufman R J
A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5939-42.
1986: Kaufman R J; Wasley L C; Furie B C; Furie B; Shoemaker C B
Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.
The Journal of biological chemistry 1986;261(21):9622-8.
1986: Kaufman R J; Murtha P; Ingolia D E; Yeung C Y; Kellems R E
Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3136-40.
1986: Ingolia D E; Yeung C Y; Shoemaker C; Kaufman R J; Kellems R E
Expression of murine ADA cDNA in bacterial and mammalian cells.
Advances in experimental medicine and biology 1986;195 Pt A():223-9.
1986: Donahue R E; Wang E A; Kaufman R J; Foutch L; Leary A C; Witek-Giannetti J S; Metzger M; Hewick R M; Steinbrink D R; Shaw G
Effects of N-linked carbohydrate on the in vivo properties of human GM-CSF.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():685-92.
1986: Fendrock B; Destrempes M; Kaufman R J; Latt S A
Cytological, flow cytometric, and molecular analysis of the rapid evolution of mammalian chromosomes containing highly amplified DNA sequences.
Histochemistry 1986;84(2):121-30.
1986: Toole J J; Pittman D; Murtha P; Wasley L C; Wang J; Amphlett G; Hewick R; Foster W B; Kamen R; Kaufman R J
Exploration of structure-function relationships in human factor VIII by site-directed mutagenesis.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():543-9.
1985: Yeung C Y; Ingolia D E; Roth D B; Shoemaker C; Al-Ubaidi M R; Yen J Y; Ching C; Bobonis C; Kaufman R J; Kellems R E
Identification of functional murine adenosine deaminase cDNA clones by complementation in Escherichia coli.
The Journal of biological chemistry 1985;260(18):10299-307.
1985: Kaufman R J; Wasley L C; Spiliotes A J; Gossels S D; Latt S A; Larsen G R; Kay R M
Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells.
Molecular and cellular biology 1985;5(7):1750-9.
1985: Gasson J C; Golde D W; Kaufman S E; Westbrook C A; Hewick R M; Kaufman R J; Wong G G; Temple P A; Leary A C; Brown E L
Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.
Nature 1985;315(6022):768-71.
1985: Jacobs K; Shoemaker C; Rudersdorf R; Neill S D; Kaufman R J; Mufson A; Seehra J; Jones S S; Hewick R; Fritsch E F
Isolation and characterization of genomic and cDNA clones of human erythropoietin.
Nature 1985;313(6005):806-10.
1985: Kaufman R J
Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(3):689-93.
1984: Toole J J; Knopf J L; Wozney J M; Sultzman L A; Buecker J L; Pittman D D; Kaufman R J; Brown E; Shoemaker C; Orr E C
Molecular cloning of a cDNA encoding human antihaemophilic factor.
Nature 1984;312(5992):342-7.
1984: Kingston R E; Kaufman R J; Sharp P A
Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity.
Molecular and cellular biology 1984;4(10):1970-7.
1984: Clark S C; Arya S K; Wong-Staal F; Matsumoto-Kobayashi M; Kay R M; Kaufman R J; Brown E L; Shoemaker C; Copeland T; Oroszlan S
Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(8):2543-7.
1983: Kaufman R J; Sharp P A
Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes.
Molecular and cellular biology 1983;3(9):1598-608.
1983: Kaufman R J; Sharp P A; Latt S A
Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.
Molecular and cellular biology 1983;3(4):699-711.
1983: Murray M J; Kaufman R J; Latt S A; Weinberg R A
Construction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimera.
Molecular and cellular biology 1983;3(1):32-43.
1982: Kaufman R J; Sharp P A
Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression.
Molecular and cellular biology 1982;2(11):1304-19.
1982: Kaufman R J; Sharp P A
Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene.
Journal of molecular biology 1982;159(4):601-21.
1981: Kaufman R J; Brown P C; Schimke R T
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.
Molecular and cellular biology 1981;1(12):1084-93.
1981: Kaufman R J; Schimke R T
Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.
Molecular and cellular biology 1981;1(12):1069-76.
1981: Handa H; Kaufman R J; Manley J; Gefter M; Sharp P A
Transcription of Simian virus 40 DNA in a HeLa whole cell extract.
The Journal of biological chemistry 1981;256(1):478-82.
1981: Schimke R T; Brown P C; Kaufman R J; McGrogan M; Slate D L
Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():785-97.
1980: Chang A C; Erlich H A; Gunsalus R P; Nunberg J H; Kaufman R J; Schimke R T; Cohen S N
Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1442-6.
1980: Nunberg J H; Kaufman R J; Chang A C; Cohen S N; Schimke R T
Structure and genomic organization of the mouse dihydrofolate reductase gene.
Cell 1980;19(2):355-64.
1979: Dolnick B J; Berenson R J; Bertino J R; Kaufman R J; Nunberg J H; Schimke R T
Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.
The Journal of cell biology 1979;83(2 Pt 1):394-402.
1979: Kaufman R J; Brown P C; Schimke R T
Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5669-73.
1979: Schimke R T; Kaufman R J; Nunberg J H; Dana S L
Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells.
Cold Spring Harbor symposia on quantitative biology 1979;43 Pt 2():1297-303.
1978: Schimke R T; Kaufman R J; Alt F W; Kellems R F
Gene amplification and drug resistance in cultured murine cells.
Science (New York, N.Y.) 1978;202(4372):1051-5.
1978: Nunberg J H; Kaufman R J; Schimke R T; Urlaub G; Chasin L A
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(11):5553-6.
1978: Chang A C; Nunberg J H; Kaufman R J; Erlich H A; Schimke R T; Cohen S N
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.
Nature 1978;275(5681):617-24.
1978: Kaufman R J; Bertino J R; Schimke R T
Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter.
The Journal of biological chemistry 1978;253(16):5852-60.
1978: Schimke R T; Alt F W; Kellems R E; Kaufman R J; Bertino J R
Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells.
Cold Spring Harbor symposia on quantitative biology 1978;42 Pt 2():649-57.

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