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Daniel Kaufmann

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Zaza M Ndhlovu; Florencia Pereyra; Alicja Piechocka-Trocha; Filippos Porichis; Jacqueline Proudfoot; Eleni Stampouloglou; Seanna Vine; Bruce D Walker; Donna Marie Alvino; Kevin Cesa; Lori B Chibnik; Philip L De Jager; Meghan G Hart; David Heckerman; R Brad Jones; Carl Kadie; Ashley McMullen; Daniel E Kaufmann
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Douglas S Kwon; Kenneth M Law; David F Pavlik; Filippos Porichis; Hendrik Streeck; Daniel P Tighe; Marylyn M Addo; Mathieu Angin; Meghan G Hart; Tomoyuki Hongo; Jessica Johnson; Daniel G Kavanagh; Daniel E Kaufmann
CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes.
Filippos Porichis; Daniel E Kaufmann
Role of PD-1 in HIV pathogenesis and as target for therapy.

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All Publications

2013: Zaza M Ndhlovu; Florencia Pereyra; Alicja Piechocka-Trocha; Filippos Porichis; Jacqueline Proudfoot; Eleni Stampouloglou; Seanna Vine; Bruce D Walker; Donna Marie Alvino; Kevin Cesa; Lori B Chibnik; Philip L De Jager; Meghan G Hart; David Heckerman; R Brad Jones; Carl Kadie; Ashley McMullen; Daniel E Kaufmann
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Blood 2013;121(5):801-11.
2012: Douglas S Kwon; Kenneth M Law; David F Pavlik; Filippos Porichis; Hendrik Streeck; Daniel P Tighe; Marylyn M Addo; Mathieu Angin; Meghan G Hart; Tomoyuki Hongo; Jessica Johnson; Daniel G Kavanagh; Daniel E Kaufmann
CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes.
Journal of virology 2012;86(12):6586-94.
2012: Filippos Porichis; Daniel E Kaufmann
Role of PD-1 in HIV pathogenesis and as target for therapy.
Current HIV/AIDS reports 2012;9(1):81-90.
2011: Jacques Thèze; Benoit Vingert; Lisa A Chakrabarti; Filippos Porichis; Daniel E Kaufmann
HIV controllers: a multifactorial phenotype of spontaneous viral suppression.
Clinical immunology (Orlando, Fla.) 2011;141(1):15-30.
2011: Christoph T Berger; Jason M Brenchley; Daniel C Douek; Nicole Frahm; Musie Ghebremichael; Kari L Hartman; Leah M Henry; Daniel E Kaufmann; Beatriz Mothe; Florencia Pereyra; David A Price; Laura E Ruff; Alessandro Sette; John Sidney; Vanessa Venturi; Bruce D Walker; Christian Brander
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Journal of virology 2011;85(18):9334-45.
2011: Filippos Porichis; Marta Rodriguez-Garcia; Daniel P Tighe; Jennifer Zupkosky; Daniel G Kavanagh; Douglas S Kwon; Ashley McMullen; David F Pavlik; Florencia Pereyra; Mark Alan Brockman; Gordon J Freeman; Daniel E Kaufmann
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Blood 2011;118(4):965-74.
2011: Filippos Porichis; Daniel E Kaufmann
HIV-specific CD4 T cells and immune control of viral replication.
Current opinion in HIV and AIDS 2011;6(3):174-80.
2011: Marta Rodríguez-García; Filippos Porichis; Olivier G de Jong; Karen Levi; Thomas J Diefenbach; Jeffrey D Lifson; Gordon J Freeman; Bruce D Walker; Daniel E Kaufmann; Daniel G Kavanagh
Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.
Journal of leukocyte biology 2011;89(4):507-15.
2010: Michael Quigley; Florencia Pereyra; Björn Nilsson; Filippos Porichis; Catia Fonseca; Quentin Eichbaum; Boris Julg; Jonathan L Jesneck; Kathleen Brosnahan; Sabrina Imam; Kate Russell; Ildiko Toth; Alicja Piechocka-Trocha; Douglas Dolfi; Jill Angelosanto; alison crawford; Haina Shin; Douglas S Kwon; Jennifer Zupkosky; Loise Francisco; Gordon J Freeman; E John Wherry; Daniel E Kaufmann; Bruce D Walker; Benjamin Ebert; W Nicholas Haining
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Nature medicine 2010;16(10):1147-51.
2010: Toshiyuki Miura; Zabrina L Brumme; Mark Alan Brockman; Pamela Rosato; Jennifer Sela; Chanson J Brumme; Florencia Pereyra; Daniel E Kaufmann; Alicja Trocha; Brian L Block; Eric S Daar; Elizabeth Connick; Heiko Jessen; Anthony D Kelleher; Eric Rosenberg; Martin Markowitz; Kim Schafer; Florin Vaida; Aikichi Iwamoto; Susan Little; Bruce D Walker
Impaired replication capacity of acute/early viruses in persons who become HIV controllers.
Journal of virology 2010;84(15):7581-91.
2010: Christoph Berger; Jonathan M Carlson; Chanson J Brumme; Kari L Hartman; Zabrina L Brumme; Leah M Henry; Pamela C Rosato; Alicja Piechocka-Trocha; Mark Alan Brockman; P Richard Harrigan; David Heckerman; Daniel E Kaufmann; Christian Brander
Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.
The Journal of experimental medicine 2010;207(1):61-75.
2010: Nadine C Salisch; Daniel E Kaufmann; Amany S Awad; R Keith Reeves; Daniel P Tighe; Yuan Li; Michael Piatak; Jeffrey D Lifson; David T Evans; Florencia Pereyra; Gordon J Freeman; R Paul Johnson
Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):476-87.
2009: Mark Alan Brockman; Douglas S Kwon; Daniel P Tighe; David F Pavlik; Pamela C Rosato; Jennifer Sela; Filippos Porichis; Sylvie Le Gall; Michael T Waring; Kristin Moss; Heiko Jessen; Florencia Pereyra; Daniel G Kavanagh; Bruce D Walker; Daniel E Kaufmann
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
Blood 2009;114(2):346-56.
2009: Daniel E Kaufmann; Bruce D Walker
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5891-7.
2009: Danni Ramduth; Cheryl L Day; Christina Thobakgale; Nompumelelo P Mkhwanazi; Chantal de Pierres; Sharon Reddy; Mary van der Stok; Zenele Mncube; Kriebashne Nair; Eshia S Moodley; Daniel E Kaufmann; Hendrik Streeck; Hoosen M Coovadia; Photini Kiepiela; Philip J R Goulder; Bruce D Walker
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
PloS one 2009;4(4):e5013.
2008: Florencia Pereyra; Marylyn M Addo; Daniel E Kaufmann; Yang Liu; Toshiyuki Miura; Almas Rathod; Brett Baker; Alicja Trocha; Rachel Rosenberg; Elizabeth Mackey; Peggy Ueda; Zhigang Lu; Daniel Cohen; Terri Wrin; Christos J Petropoulos; Eric S Rosenberg; Bruce D Walker
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
The Journal of infectious diseases 2008;197(4):563-71.
2007: Nicole Frahm; Daniel E Kaufmann; Karina Yusim; Mark Muldoon; Can Kesmir; Caitlyn H Linde; Will Fischer; Todd M Allen; Bin Li; Ben H McMahon; Kellie L Faircloth; Hannah S Hewitt; Elizabeth W Mackey; Toshiyuki Miura; Ashok Khatri; Steven Wolinsky; Andrew McMichael; Robert Funkhouser; Bruce D Walker; Christian Brander; Bette T Korber
Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6638-50.
2007: Daniel E Kaufmann; Daniel G Kavanagh; Florencia Pereyra; John J Zaunders; Elizabeth W Mackey; Toshiyuki Miura; Sarah Palmer; Mark Alan Brockman; Almas Rathod; Alicja Piechocka-Trocha; Brett Baker; Baogong Zhu; Sylvie Le Gall; Michael T Waring; Ryan Ahern; Kristin Moss; Anthony D Kelleher; John M Coffin; Gordon J Freeman; Eric S Rosenberg; Bruce D Walker
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Nature immunology 2007;8(11):1246-54.
2007: Florian Bihl; Murli Narayan; John V Chisholm; Leah M Henry; Todd J Suscovich; Elizabeth E Brown; Tania M Welzel; Daniel E Kaufmann; Tauheed M Zaman; Sheila Dollard; Jeffrey N Martin; Fred Wang; David T Scadden; Kenneth M Kaye; Christian Brander
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Journal of virology 2007;81(9):4904-8.
2006: Arthur Y Kim; julian schulze zur wiesch; Thomas Kuntzen; Joerg Timm; Daniel E Kaufmann; Jared E Duncan; Andrea M Jones; Alysse Wurcel; Benjamin T Davis; Rajesh T Gandhi; Gregory Robbins; Todd M Allen; Raymond T Chung; Georg M Lauer; Bruce D Walker
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.
PLoS medicine 2006;3(12):e492.
2006: John J Zaunders; Susanna Ip; Mee Ling Munier; Daniel E Kaufmann; Kazuo Suzuki; Choechoe Brereton; Sarah Sasson; Nabila Seddiki; Kersten Koelsch; Alan Landay; Pat Grey; Robert Finlayson; John Kaldor; Eric S Rosenberg; Bruce D Walker; Barbara Fazekas De St Groth; David A Cooper; Anthony D Kelleher
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
Journal of virology 2006;80(20):10162-72.
2006: Cheryl L Day; Daniel E Kaufmann; Photini Kiepiela; Julia A Brown; Eshia Moodley; Sharon Reddy; Elizabeth W Mackey; Joseph D Miller; Alasdair Leslie; Chantal DePierres; Zenele Mncube; Jaikumar Duraiswamy; Baogong Zhu; Quentin Eichbaum; Marcus Altfeld; E John Wherry; Hoosen M Coovadia; Philip J R Goulder; Paul Klenerman; Rafi Ahmed; Gordon J Freeman; Bruce D Walker
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Nature 2006;443(7109):350-4.
2006: Daniel G Kavanagh; Daniel E Kaufmann; Sherzana Sunderji; Nicole Frahm; Sylvie Le Gall; David Boczkowski; Eric S Rosenberg; David R Stone; Mary N Johnston; Bradford S Wagner; M Tauheed Zaman; Christian Brander; Eli Gilboa; Bruce D Walker; Nina Bhardwaj
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.
Blood 2006;107(5):1963-9.
2005: Todd M Allen; Marcus Altfeld; Shaun C Geer; Elizabeth T Kalife; Corey Moore; Kristin M O'Sullivan; Ivna Desouza; Margaret E Feeney; Robert L Eldridge; Erica L Maier; Daniel E Kaufmann; Matthew P Lahaie; Laura L Reyor; Giancarlo O Tanzi; Mary N Johnston; Christian Brander; Rika Draenert; Jürgen K Rockstroh; Heiko Jessen; Eric S Rosenberg; Simon Mallal; Bruce D Walker
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology 2005;79(21):13239-49.
2005: John J Zaunders; Mee Ling Munier; Daniel E Kaufmann; Susanna Ip; Pat Grey; Don Smith; Tim Ramacciotti; Dick Quan; Robert Finlayson; John Kaldor; Eric S Rosenberg; Bruce D Walker; David A Cooper; Anthony D Kelleher
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.
Blood 2005;106(5):1660-7.
2004: Daniel E Kaufmann; Mathias Lichterfeld; Marcus Altfeld; Marylyn M Addo; Mary N Johnston; Paul K Lee; Bradford S Wagner; Elizabeth T Kalife; Daryld Strick; Eric S Rosenberg; Bruce D Walker
Limited durability of viral control following treated acute HIV infection.
PLoS medicine 2004;1(2):e36.
2004: Mathias Lichterfeld; Daniel E Kaufmann; Xu G Yu; Stanley K Mui; Marylyn M Addo; Mary N Johnston; Daniel Cohen; Gregory Robbins; Eunice Pae; Galit Alter; Alysse Wurcel; David Stone; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
The Journal of experimental medicine 2004;200(6):701-12.
2004: Philip J Norris; Howell F Moffett; Otto O Yang; Daniel E Kaufmann; Margaret J Clark; Marylyn M Addo; Eric S Rosenberg
Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.
Journal of virology 2004;78(16):8844-51.
2004: Daniel E Kaufmann; Paul M Bailey; John Sidney; Bradford Wagner; Philip J Norris; Mary N Johnston; Lisa A Cosimi; Marylyn M Addo; Mathias Lichterfeld; Marcus Altfeld; Nicole Frahm; Christian Brander; Alessandro Sette; Bruce D Walker; Eric S Rosenberg
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology 2004;78(9):4463-77.
2004: Philip J Norris; Howell F Moffett; Christian Brander; Todd M Allen; Kristin M O'Sullivan; Lisa A Cosimi; Daniel E Kaufmann; Bruce D Walker; Eric S Rosenberg
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
AIDS research and human retroviruses 2004;20(3):315-25.