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Scott Kaufmann

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Ming Y Lim; Mark R Litzow; Animesh Pardanani; Mrinal S Patnaik; Ayalew Tefferi; Alexandra P Wolanskyj; Aref Al-Kali; Aneel A Ashrani; Kebede H Begna; Michelle A Elliott; Diane E Grill; William J Hogan; C Christopher Hook; Scott H Kaufmann; Louis Letendre; Rajiv K Pruthi
Comparison of complication rates of Hickman(®) catheters versus peripherally inserted central catheters in patients with acute myeloid leukemia undergoing induction chemotherapy.
Erin L Schenk; B Douglas Smith; Brian D Koh; David Parry; Kevin L Peterson; Karen Flatten; Allan Hess; Larry M Karnitz; Judith E Karp; Scott H Kaufmann
Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro.
Anand G Patel; Guy G Poirier; Silvana B De Lorenzo; Karen Flatten; Scott H Kaufmann
Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro.

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2013: Ming Y Lim; Mark R Litzow; Animesh Pardanani; Mrinal S Patnaik; Ayalew Tefferi; Alexandra P Wolanskyj; Aref Al-Kali; Aneel A Ashrani; Kebede H Begna; Michelle A Elliott; Diane E Grill; William J Hogan; C Christopher Hook; Scott H Kaufmann; Louis Letendre; Rajiv K Pruthi
Comparison of complication rates of Hickman(®) catheters versus peripherally inserted central catheters in patients with acute myeloid leukemia undergoing induction chemotherapy.
Leukemia & lymphoma 2013;54(6):1263-7.
2012: Erin L Schenk; B Douglas Smith; Brian D Koh; David Parry; Kevin L Peterson; Karen Flatten; Allan Hess; Larry M Karnitz; Judith E Karp; Scott H Kaufmann
Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(19):5364-73.
2012: Anand G Patel; Guy G Poirier; Silvana B De Lorenzo; Karen Flatten; Scott H Kaufmann
Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(6):1655-62.
2012: Michelle A Elliott; William J Hogan; C Christopher Hook; Scott H Kaufmann; Louis Letendre; Animesh Pardanani; Rajiv K Pruthi; Ayalew Tefferi; alexandra wolanskyj; Aref Al-Kali; Aneel A Ashrani; Kebede H Begna; Mark R Litzow
Therapy-related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy.
European journal of haematology 2012;88(3):237-43.
2012: Gregory J Gores; Scott H Kaufmann
Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors.
Genes & development 2012;26(4):305-11.
2012: Anand G Patel; Guy G Poirier; Paula A Schneider; Nga T Dai; Karen Flatten; Jennifer S McDonald; Scott H Kaufmann
Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.
The Journal of biological chemistry 2012;287(6):4198-210.
2012: Andrea E Wahner Hendrickson; John K Camoriano; Gerardo Colon-Otero; Charles Erlichman; Gretchen Glaser; S Percy Ivy; Larry M Karnitz; Scott H Kaufmann; Ann L Oberg; Prema P Peethambaram; Paul Haluska
A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma.
Gynecologic oncology 2012;124(2):210-5.
2011: Thomas E Witzig; Cristine Allmer; Stephen M Ansell; Joseph P Colgan; Husheng Ding; Mamta Gupta; Thomas M Habermann; Ray Hohl; David J Inwards; Patrick B Johnston; Paul J Kurtin; Brian K Link; David Loegering; Svetomir N Markovic; Matthew J Maurer; Ivana N M Micallef; Grzegorz S Nowakowski; Kevin Peterson; Luis F Porrata; Paula Schneider; Hui Tang; Carrie A Thompson; George Weiner; Scott H Kaufmann
Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas.
Blood 2011;118(18):4882-9.
2011: Nan Soon Wong; Yali Zhu; Alex A. Adjei; David L Cutler; Scott H Kaufmann; Kellen L Meadows; Michael L Meyers; Michael A Morse; William P Petros; Lee S Rosen; Paul Statkevich; Herbert I Hurwitz
A phase I multicenter study of continuous oral administration of lonafarnib (SCH 66336) and intravenous gemcitabine in patients with advanced cancer.
Cancer investigation 2011;29(9):617-25.
2011: Haiming Dai; X Wei Meng; Yuan-Ping Pang; Paula A Schneider; Alyson Smith; Scott H Kaufmann
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization.
The Journal of cell biology 2011;194(1):39-48.
2011: Xiaonan Hou; Fei Huang; Joan M Carboni; Karen Flatten; Yan W Asmann; Cynthia Ten Eyck; Takeo Nakanishi; Jennifer D Tibodeau; Douglas Ross; Marco Gottardis; Charles Erlichman; Scott H Kaufmann; Paul Haluska
Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924.
Molecular cancer therapeutics 2011;10(1):117-25.
2010: Anand G Patel; Scott H Kaufmann
Cancer. Targeting bacteria to improve cancer therapy.
Science (New York, N.Y.) 2010;330(6005):766-7.
2010: Catherine J Huntoon; Monica D Nye; Liyi Geng; Kevin L Peterson; Karen Flatten; Paul Haluska; Scott H Kaufmann; Larry M Karnitz
Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.
Cancer research 2010;70(21):8642-50.
2010: Ivette M Sosa Seda; Justin L Mott; Yuko Akazawa; Fernando J Barreyro; Steven F Bronk; Scott H Kaufmann; Gregory J Gores
Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(7):701-10.
2010: Xue Wei Meng; Michael P Heldebrant; Karen Flatten; David Loegering; Haiming Dai; Paula A Schneider; Timothy Gomez; Kevin L Peterson; Sergey A Trushin; Allan Hess; B Douglas Smith; Judith E Karp; Daniel D Billadeau; Scott H Kaufmann
Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
The Journal of biological chemistry 2010;285(2):888-902.
2010: Anand Patel; Scott H Kaufmann
Development of PARP inhibitors: an unfinished story.
Oncology (Williston Park, N.Y.) 2010;24(1):66, 68.
2009: Andrea E Wahner Hendrickson; Paul Haluska; Paula A Schneider; David Loegering; Kevin L Peterson; Ricardo M Attar; B Douglas Smith; Charles Erlichman; Marco Gottardis; Judith E Karp; Joan M Carboni; Scott H Kaufmann
Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro.
Cancer research 2009;69(19):7635-43.
2009: Mamta Gupta; Stephen M Ansell; Anne J Novak; Shaji Kumar; Scott H Kaufmann; Thomas E Witzig
Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2.
Blood 2009;114(14):2926-35.
2009: Zheng Fu; Kevin Regan; Lizhi Zhang; Michael H Muders; Stephen N Thibodeau; Amy French; Yanhong Wu; Scott H Kaufmann; Wilma L Lingle; Junjie Chen; Donald J Tindall
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.
The Journal of clinical investigation 2009;119(9):2714-24.
2009: Marina Gálvez-Peralta; Jennifer S Hackbarth; Karen Flatten; Scott H Kaufmann; Hiroshi Hiasa; Chenguo Xing; David M Ferguson
On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
Bioorganic & medicinal chemistry letters 2009;19(15):4459-62.
2008: Julian R Molina; Scott H Kaufmann; Joel M Reid; Stephen D Rubin; Marina Gálvez-Peralta; Robert Friedman; Karen Flatten; Kevin M Koch; Tona M Gilmer; Robert J Mullin; Roxanne C Jewell; Sara J Felten; Sumithra J Mandrekar; Alex A. Adjei; Charles Erlichman
Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7900-8.
2008: Andrea Wahner Hendrickson; Xue Wei Meng; Scott H Kaufmann
Anticancer therapy: boosting the bang of Bim.
The Journal of clinical investigation 2008;118(11):3582-4.
2008: Marina Gálvez-Peralta; Nga T Dai; David Loegering; Karen Flatten; Stephanie L Safgren; Jill M Wagner; Matthew M Ames; Larry M Karnitz; Scott H Kaufmann
Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines.
Molecular pharmacology 2008;74(3):724-35.
2008: Stephen M Ansell; David J Inwards; Kendrith M Rowland; Patrick J Flynn; Roscoe F Morton; Dennis F Moore; Scott H Kaufmann; Irene M Ghobrial; Paul J Kurtin; Matthew Maurer; Cristine Allmer; Thomas E Witzig
Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group.
Cancer 2008;113(3):508-14.
2008: Scott H Kaufmann; Sun-Hee Lee; X Wei Meng; David Loegering; Timothy J Kottke; Alexander J Henzing; Sandrine Ruchaud; Kumiko Samejima; William C Earnshaw
Apoptosis-associated caspase activation assays.
Methods (San Diego, Calif.) 2008;44(3):262-72.
2007: Xue Wei Meng; Sun-Hee Lee; Haiming Dai; David Loegering; Chunrong Yu; Karen Flatten; Paula Schneider; Nga T Dai; Shaji Kumar; B Douglas Smith; Judith E Karp; Alex A. Adjei; Scott H Kaufmann
Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.
The Journal of biological chemistry 2007;282(41):29831-46.
2007: Nathan W Werneburg; Maria Eugenia Guicciardi; Steven F Bronk; Scott H Kaufmann; Gregory J Gores
Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins.
The Journal of biological chemistry 2007;282(39):28960-70.
2007: Shogo Kobayashi; Sun-Hee Lee; Xue W Meng; Justin L Mott; Steven F Bronk; Nathan W Werneburg; Ruth W Craig; Scott H Kaufmann; Gregory J Gores
Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.
The Journal of biological chemistry 2007;282(25):18407-17.
2007: Son B Le; M Katie Hailer; Sarah Buhrow; Qi Wang; Karen Flatten; Peter Pediaditakis; Keith C Bible; Lionel D Lewis; Edward A Sausville; Yuan-Ping Pang; Matthew M Ames; John J Lemasters; Ekhson L Holmuhamedov; Scott H Kaufmann
Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.
The Journal of biological chemistry 2007;282(12):8860-72.
2007: Jeffrey E Lancet; Ivana Gojo; Jason Gotlib; Eric J Feldman; Jacqueline Greer; Jane L Liesveld; Laura M Bruzek; Lawrence Morris; Youn Park; Alex A. Adjei; Scott H Kaufmann; Elizabeth Garrett-Mayer; Peter L Greenberg; John J Wright; Judith E Karp
A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia.
Blood 2007;109(4):1387-94.
2006: Xue Wei Meng; Sun-Hee Lee; Scott H Kaufmann
Apoptosis in the treatment of cancer: a promise kept?
Current opinion in cell biology 2006;18(6):668-76.
2006: Ruben A Mesa; Ayalew Tefferi; T S Lasho; David Loegering; Rebecca F McClure; Heather L Powell; Nga T Dai; David P Steensma; Scott H Kaufmann
Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia.
Leukemia 2006;20(10):1800-8.
2006: Chunrong Yu; Bret B Friday; Jin-Ping Lai; Lin Yang; Jann N. Sarkaria; Neil E Kay; Christopher A Carter; Lewis Roberts; Scott H Kaufmann; Alex A. Adjei
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways.
Molecular cancer therapeutics 2006;5(9):2378-87.
2006: Jeremy Chien; Giacomo Aletti; Alfonso Baldi; Vincenzo Catalano; Pietro Muretto; Gary L Keeney; Kimberly R Kalli; Julie Staub; Michael Ehrmann; William A Cliby; Yean Kit Lee; Keith C Bible; Lynn C Hartmann; Scott H Kaufmann; Viji Shridhar
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.
The Journal of clinical investigation 2006;116(7):1994-2004.
2006: David P Steensma; Rebecca F McClure; Judith E Karp; Ayalew Tefferi; Terra L Lasho; Heather L Powell; Gordon W Dewald; Scott H Kaufmann
JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained.
Leukemia 2006;20(6):971-8.
2006: Joya Chandra; Jeannette Tracy; David Loegering; Karen Flatten; Srdan Verstovsek; Miloslav Beran; Mercedes Gorre; Zeev Estrov; Nicholas J Donato; Moshe Talpaz; Charles L Sawyers; Kapil N Bhalla; Judith E Karp; Edward A Sausville; Scott H Kaufmann
Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance.
Blood 2006;107(6):2501-6.
2006: Sandrine Ruchand; Kumiko Samejima; Damien Hudson; Scott H Kaufmann; William C Earnshaw
Genetic analysis of apoptotic execution.
Sub-cellular biochemistry 2006;40():75-90.
2006: Son B Le; Ekhson L Holmuhamedov; V L Narayanan; Edward A Sausville; Scott H Kaufmann
Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes.
Cell death and differentiation 2006;13(1):151-9.
2005: Scott H Kaufmann; David P Steensma
On the TRAIL of a new therapy for leukemia.
Leukemia 2005;19(12):2195-202.
2005: Larry M Karnitz; Karen Flatten; Jill M Wagner; David Loegering; Jennifer S Hackbarth; Sonnet J H Arlander; Ben Vroman; M Bijoy Thomas; Yong-Un Baek; Kevin M Hopkins; Howard B Lieberman; Junjie Chen; William A Cliby; Scott H Kaufmann
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.
Molecular pharmacology 2005;68(6):1636-44.
2005: Chunrong Yu; Laura M Bruzek; Xue Wei Meng; Gregory J Gores; Christopher A Carter; Scott H Kaufmann; Alex A. Adjei
The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.
Oncogene 2005;24(46):6861-9.
2005: Scott H Kaufmann; Judith E Karp; Louis Letendre; Timothy J Kottke; Stephanie L Safgren; Jacqueline Greer; Ivana Gojo; Pamela J Atherton; Phyllis A Svingen; David Loegering; Mark R Litzow; Jeff A Sloan; Joel M Reid; Matthew M Ames; Alex A. Adjei; Charles Erlichman
Phase I and pharmacologic study of infusional topotecan and Carboplatin in relapsed and refractory acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6641-9.
2005: Keith C Bible; Janet L Lensing; Sacha A Nelson; Yean K Lee; Joel M Reid; Matthew M Ames; Crescent R Isham; Jill Piens; Stacie L Rubin; Joseph Rubin; Scott H Kaufmann; Pamela J Atherton; Jeff A Sloan; Michelle K Daiss; Alex A. Adjei; Charles Erlichman
Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5935-41.
2005: Laura M Bruzek; Jenny N Poynter; Scott H Kaufmann; Alex A. Adjei
Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336).
Molecular pharmacology 2005;68(2):477-86.
2005: Jeremy Chien; Julie Staub; Rajeswari Avula; Heyu Zhang; Wanguo Liu; Lynn C Hartmann; Scott H Kaufmann; David I Smith; Viji Shridhar
Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.
Oncogene 2005;24(32):5089-100.
2005: Ruben A Mesa; David Loegering; Heather L Powell; Karen Flatten; Sonnet J H Arlander; Nga T Dai; Michael P Heldebrant; Ben Vroman; B Douglas Smith; Judith E Karp; Cynthia J Ten Eyck; Charles Erlichman; Scott H Kaufmann; Larry M Karnitz
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
Blood 2005;106(1):318-27.
2005: Shogo Kobayashi; Nathan W Werneburg; Steven F Bronk; Scott H Kaufmann; Gregory J Gores
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Gastroenterology 2005;128(7):2054-65.
2005: Grace K Dy; James P Thomas; George Wilding; Laura M Bruzek; Sumithra J Mandrekar; Charles Erlichman; Dona Alberti; Kim Binger; Henry C Pitot; Steven R Alberts; Lorelei J Hanson; Rebecca Marnocha; Kendra Tutsch; Scott H Kaufmann; Alex A. Adjei
A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3410-6.
2005: Irene M Ghobrial; Daniel J McCormick; Scott H Kaufmann; Alexey A Leontovich; David Loegering; Nga T Dai; Kelly L Krajnik; Mary J Stenson; Mona F Melhem; Anne J Novak; Stephen M Ansell; Thomas E Witzig
Proteomic analysis of mantle-cell lymphoma by protein microarray.
Blood 2005;105(9):3722-30.
2005: Karen Flatten; Nga T Dai; Ben Vroman; David Loegering; Charles Erlichman; Larry M Karnitz; Scott H Kaufmann
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.
The Journal of biological chemistry 2005;280(14):14349-55.
2005: Grace K Dy; Laura M Bruzek; Gary A Croghan; Sumithra J Mandrekar; Charles Erlichman; Prema P Peethambaram; Henry C Pitot; Lorelei J Hanson; Joel M Reid; Alfred F Furth; Shinta Cheng; Robert E Martell; Scott H Kaufmann; Alex A. Adjei
A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662, in combination with paclitaxel and carboplatin in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1877-83.
2005: Tait D Shanafelt; Yean K Lee; Nancy D Bone; Ann K Strege; Ven L Narayanan; Edward A Sausville; Susan M Geyer; Scott H Kaufmann; Neil E Kay
Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine.
Blood 2005;105(5):2099-106.
2004: Jennifer S Hackbarth; Sun-Hee Lee; Xue Wei Meng; Ben Vroman; Scott H Kaufmann; Larry M Karnitz
S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells.
BioTechniques 2004;37(5):835-9.
2004: Phyllis A Svingen; David Loegering; Joe Rodriquez; Xue Wei Meng; Peter W Mesner; Susan Holbeck; Anne Monks; Stan Krajewski; Dominic A Scudiero; Edward A Sausville; John C Reed; Yuri A Lazebnik; Scott H Kaufmann
Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6807-20.
2004: Melissa Alsina; Rafael Fonseca; Edward F Wilson; A Nelida Belle; Elvira Gerbino; Tammy Price-Troska; Rose M Overton; Gregory J Ahmann; Laura M Bruzek; Alex A. Adjei; Scott H Kaufmann; John J Wright; Daniel Sullivan; Benjamin Djulbegovic; Alan B Cantor; Philip R Greipp; William S Dalton; Said M Sebti
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma.
Blood 2004;103(9):3271-7.
2004: David Loegering; Sonnet J H Arlander; Jennifer S Hackbarth; Ben Vroman; Pia Roos-Mattjus; Kevin M Hopkins; Howard B Lieberman; Larry M Karnitz; Scott H Kaufmann
Rad9 protects cells from topoisomerase poison-induced cell death.
The Journal of biological chemistry 2004;279(18):18641-7.
2004: Jeremy Chien; Julie Staub; Shou-Ih Hu; Michele Erickson-Johnson; Fergus J. Couch; David I Smith; Robert M Crowl; Scott H Kaufmann; Viji Shridhar
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.
Oncogene 2004;23(8):1636-44.
2004: Nadia Korfali; Sandrine Ruchaud; David Loegering; Delphine Bernard; Colin Dingwall; Scott H Kaufmann; William C Earnshaw
Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.
The Journal of biological chemistry 2004;279(2):1030-9.
2003: Joya Chandra; Jennifer S Hackbarth; Son B Le; David Loegering; Nancy D Bone; Laura M Bruzek; Ven L Narayanan; Alex A. Adjei; Neil E Kay; Ayalew Tefferi; Judith E Karp; Edward A Sausville; Scott H Kaufmann
Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.
Blood 2003;102(13):4512-9.
2003: Kimberly R Kalli; Kathryn E Devine; Myles C Cabot; Christina R Arnt; Michael P Heldebrant; Phyllis A Svingen; Charles Erlichman; Lynn C Hartmann; Cheryl A Conover; Scott H Kaufmann
Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines.
Molecular pharmacology 2003;64(6):1434-43.
2003: Xue Wei Meng; Joya Chandra; David Loegering; Keri Van Becelaere; Timothy J Kottke; Steven D Gore; Judith E Karp; Judith Leopold; Scott H Kaufmann
Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro.
The Journal of biological chemistry 2003;278(47):47326-39.
2003: Scott H Kaufmann; David L Vaux
Alterations in the apoptotic machinery and their potential role in anticancer drug resistance.
Oncogene 2003;22(47):7414-30.
2003: Alex A. Adjei; Gary A Croghan; Charles Erlichman; Randolph S Marks; Joel M Reid; Jeff A Sloan; Henry C Pitot; Steven R Alberts; Richard M Goldberg; Lorelei J Hanson; Laura M Bruzek; Pamela J Atherton; Alain Thibault; Peter A Palmer; Scott H Kaufmann
A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2520-6.
2003: Jinping Lai; Jeremy Chien; Julie Staub; Rajeswari Avula; Eddie L Greene; Tori A Matthews; David I Smith; Scott H Kaufmann; Lewis Roberts; Viji Shridhar
Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.
The Journal of biological chemistry 2003;278(25):23107-17.
2003: Alex A. Adjei; Ann Mauer; Laura M Bruzek; Randolph S Marks; Shauna Hillman; Susan Geyer; Lorelei J Hanson; John J Wright; Charles Erlichman; Scott H Kaufmann; Everett E Vokes
Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(9):1760-6.
2003: Jan C Buckner; Joel M Reid; Keith Wright; Scott H Kaufmann; Charles Erlichman; Matthew Ames; Steve Cha; Judith R O'Fallon; Lawrence J Schaaf; Langdon L Miller
Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group.
Cancer 2003;97(9 Suppl):2352-8.
2002: Jung-Hwan Yoon; Nathan W Werneburg; Hajime Higuchi; Ali Canbay; Scott H Kaufmann; Cahit Akgul; Steven W Edwards; Gregory J Gores
Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.
Cancer research 2002;62(22):6500-5.
2002: Christina R Arnt; Mihnea V Chiorean; Michael P Heldebrant; Gregory J Gores; Scott H Kaufmann
Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ.
The Journal of biological chemistry 2002;277(46):44236-43.
2002: Richard M Goldberg; Scott H Kaufmann; Pamela J Atherton; Jeff A Sloan; Alex A. Adjei; Henry C Pitot; Steven R Alberts; Joseph Rubin; L L Miller; Charles Erlichman
A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(10):1674-80.
2002: Alex A. Adjei; Joel M Reid; Charles Erlichman; Jeff A Sloan; Henry C Pitot; Steven R Alberts; Richard M Goldberg; Lorelei J Hanson; Stacie Ruben; Scott A Boemer; Pamela J Atherton; Matthew M Ames; Scott H Kaufmann
A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer.
Investigational new drugs 2002;20(3):297-304.
2002: April L Blajeski; Vy A Phan; Timothy J Kottke; Scott H Kaufmann
G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells.
The Journal of clinical investigation 2002;110(1):91-9.
2002: Mary J Kuffel; Jennifer C Schroeder; Lori J Pobst; Stephen Naylor; Joel M Reid; Scott H Kaufmann; Matthew M Ames
Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.
Molecular pharmacology 2002;62(1):143-53.
2002: E M Sotomayor; Steven Piantadosi; Carole B Miller; Judith E Karp; Richard J Jones; S D Rowley; Scott H Kaufmann; Hayden Braine; PJ Burke; Steven D Gore
Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy.
Leukemia research 2002;26(5):461-71.
2002: Sandrine Ruchaud; Nadia Korfali; Pascal Villa; Timothy J Kottke; Colin Dingwall; Scott H Kaufmann; William C Earnshaw
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.
The EMBO journal 2002;21(8):1967-77.
2002: Jung-Hwan Yoon; Hajime Higuchi; Nathan W Werneburg; Scott H Kaufmann; Gregory J Gores
Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
Gastroenterology 2002;122(4):985-93.
2002: Xue Wei Meng; Michael P Heldebrant; Scott H Kaufmann
Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain.
The Journal of biological chemistry 2002;277(5):3776-83.
2002: Benjamin M F Mow; Joya Chandra; Phyllis A Svingen; Christopher G Hallgren; Ellen Weisberg; Timothy J Kottke; Ven L Narayanan; Mark R Litzow; James D Griffin; Edward A Sausville; Ayalew Tefferi; Scott H Kaufmann
Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro.
Blood 2002;99(2):664-71.
2002: Timothy J Kottke; April L Blajeski; Xue Wei Meng; Phyllis A Svingen; Sandrine Ruchaud; Peter W Mesner; Scott A Boerner; Kumiko Samejima; Nico Henriquez; Tamie J Chilcote; Janet Lord; Michael Salmon; William C Earnshaw; Scott H Kaufmann
Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells.
The Journal of biological chemistry 2002;277(1):804-15.
2001: Judith E Karp; Scott H Kaufmann; Alex A. Adjei; Jeffrey E Lancet; John J Wright; David W End
Current status of clinical trials of farnesyltransferase inhibitors.
Current opinion in oncology 2001;13(6):470-6.
2001: Benjamin M F Mow; A L Blajeski; J Chandra; Scott H Kaufmann
Apoptosis and the response to anticancer therapy.
Current opinion in oncology 2001;13(6):453-62.
2001: April L Blajeski; Timothy J Kottke; Scott H Kaufmann
A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines.
Experimental cell research 2001;270(2):277-88.
2001: Scott H Kaufmann
Reutilization of immunoblots after chemiluminescent detection.
Analytical biochemistry 2001;296(2):283-6.
2001: Scott H Kaufmann; Timothy J Kottke; LM Martins; A J Henzing; William C Earnshaw
Analysis of caspase activation during apoptosis.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 18():Unit 18.2.
2001: Gregory J Gores; Scott H Kaufmann
Is TRAIL hepatotoxic?
Hepatology (Baltimore, Md.) 2001;34(1):3-6.
2001: Judith E Karp; Jeffrey E Lancet; Scott H Kaufmann; David W End; John J Wright; K Bol; I Horak; Michael L Tidwell; Jane L Liesveld; Timothy J Kottke; D Ange; Laxmi N Buddharaju; Ivana Gojo; W Edward Highsmith; Robert T Belly; R J Hohl; M E Rybak; A Thibault; Joseph D Rosenblatt
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial.
Blood 2001;97(11):3361-9.
2001: Scott A Boerner; M E Tourne; Scott H Kaufmann; Keith C Bible
Effect of P-glycoprotein on flavopiridol sensitivity.
British journal of cancer 2001;84(10):1391-6.
2001: Viji Shridhar; K C Bible; Julie Staub; Rajeswari Avula; Y K Lee; Kimberly R Kalli; H Huang; Lynn C Hartmann; Scott H Kaufmann; David I Smith
Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.
Cancer research 2001;61(10):4258-65.
2001: Alex A. Adjei; JN Davis; Laura M Bruzek; Charles Erlichman; Scott H Kaufmann
Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1438-45.
2001: Charles Erlichman; Scott A Boerner; C G Hallgren; R Spieker; X Y Wang; C David James; George L Scheffer; Marc Maliepaard; Douglas Ross; Keith C Bible; Scott H Kaufmann
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.
Cancer research 2001;61(2):739-48.
2000: Phyllis A Svingen; Judith E Karp; Stan Krajewski; Peter W Mesner; Steven D Gore; PJ Burke; John C Reed; Y A Lazebnik; Scott H Kaufmann
Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia.
Blood 2000;96(12):3922-31.
2000: Maria Eugenia Guicciardi; J Deussing; H Miyoshi; Steven F Bronk; Phyllis A Svingen; C Peters; Scott H Kaufmann; Gregory J Gores
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.
The Journal of clinical investigation 2000;106(9):1127-37.
2000: Scott H Kaufmann; Gregory J Gores
Apoptosis in cancer: cause and cure.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(11):1007-17.
2000: Muthusamy Thangaraju; Scott H Kaufmann; Fergus J. Couch
BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines.
The Journal of biological chemistry 2000;275(43):33487-96.
2000: Alex A. Adjei; JN Davis; Charles Erlichman; Phyllis A Svingen; Scott H Kaufmann
Comparison of potential markers of farnesyltransferase inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2318-25.
2000: Keith C Bible; Roy H Bible; Timothy J Kottke; Phyllis A Svingen; K Xu; Y P Pang; Elisabeth Hajdu; Scott H Kaufmann
Flavopiridol binds to duplex DNA.
Cancer research 2000;60(9):2419-28.
2000: Scott H Kaufmann; William C Earnshaw
Induction of apoptosis by cancer chemotherapy.
Experimental cell research 2000;256(1):42-9.
2000: Alex A. Adjei; Charles Erlichman; JN Davis; David L Cutler; Jeff A Sloan; Randolph S Marks; Lorelei J Hanson; Phyllis A Svingen; Pamela J Atherton; W Robert Bishop; Paul Kirschmeier; Scott H Kaufmann
A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.
Cancer research 2000;60(7):1871-7.
2000: II Budihardjo; Scott A Boerner; S Eckdahl; Phyllis A Svingen; R Rios; Matthew M Ames; Scott H Kaufmann
Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity.
Molecular pharmacology 2000;57(3):529-38.
2000: E Perola; K Xu; Thomas Kollmeyer; Scott H Kaufmann; F G Prendergast; Yuan-Ping Pang
Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.
Journal of medicinal chemistry 2000;43(3):401-8.
2000: Keith C Bible; Scott A Boerner; K Kirkland; Kari L Anderl; D Bartelt; Phyllis A Svingen; Timothy J Kottke; Yean K Lee; S Eckdahl; P G Stalboerger; Robert B Jenkins; Scott H Kaufmann
Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):661-70.
2000: Scott H Kaufmann; Peter W Mesner; K Samejima; Shigenobu Toné; William C Earnshaw
Detection of DNA cleavage in apoptotic cells.
Methods in enzymology 2000;322():3-15.
2000: Phyllis A Svingen; Ayalew Tefferi; Timothy J Kottke; Gurmeet Kaur; Ven L Narayanan; Edward A Sausville; Scott H Kaufmann
Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):237-49.
1999: Denise L Walker; Joel M Reid; Phyllis A Svingen; R Rios; Joseph M Covey; M C Alley; M G Hollingshead; II Budihardjo; S Eckdahl; Scott A Boerner; Scott H Kaufmann; Matthew M Ames
Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent.
Biochemical pharmacology 1999;58(6):1057-66.
1999: Peter W Mesner; Keith C Bible; LM Martins; Timothy J Kottke; S M Srinivasula; Phyllis A Svingen; Tamie J Chilcote; Guriqbal S Basi; jay tung; Stan Krajewski; John C Reed; E S Alnemri; William C Earnshaw; Scott H Kaufmann
Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile.
The Journal of biological chemistry 1999;274(32):22635-45.
1999: Timothy J Kottke; April L Blajeski; LM Martins; Peter W Mesner; Nancy E Davidson; William C Earnshaw; Deborah K Armstrong; Scott H Kaufmann
Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis.
The Journal of biological chemistry 1999;274(22):15927-36.
1999: Kumiko Samejima; Phyllis A Svingen; Guriqbal S Basi; T Kottke; Peter W Mesner; L Stewart; F Durrieu; Guy G Poirier; E S Alnemri; J J Champoux; Scott H Kaufmann; William C Earnshaw
Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis.
The Journal of biological chemistry 1999;274(7):4335-40.
1999: Keith C Bible; Scott A Boerner; Scott H Kaufmann
A one-step method for protein estimation in biological samples: nitration of tyrosine in nitric acid.
Analytical biochemistry 1999;267(1):217-21.
1999: Scott H Kaufmann; Phyllis A Svingen
Immunoblot analysis and band depletion assays.
Methods in molecular biology (Clifton, N.J.) 1999;94():253-68.
1999: William C Earnshaw; LM Martins; Scott H Kaufmann
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
Annual review of biochemistry 1999;68():383-424.
1999: William A Faubion; Maria Eugenia Guicciardi; H Miyoshi; Steven F Bronk; PJ Roberts; Phyllis A Svingen; Scott H Kaufmann; Gregory J Gores
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.
The Journal of clinical investigation 1999;103(1):137-45.
1998: Steven D Gore; Eric K Rowinsky; Carole B Miller; Constance A Griffin; Tian Ling Chen; Michael J Borowitz; Ross C Donehower; Kathleen Burks; Deborah K Armstrong; PJ Burke; Michael R Grever; Scott H Kaufmann
A phase II "window" study of topotecan in untreated patients with high risk adult acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2677-89.
1998: LM Martins; Timothy J Kottke; Scott H Kaufmann; William C Earnshaw
Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis.
Blood 1998;92(9):3042-9.
1998: Kumiko Samejima; Shigenobu Toné; Timothy J Kottke; M Enari; Hideki Sakahira; CA Cooke; F Durrieu; LM Martins; Shigekazu Nagata; Scott H Kaufmann; William C Earnshaw
Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.
The Journal of cell biology 1998;143(1):225-39.
1998: Scott H Kaufmann
Cell death induced by topoisomerase-targeted drugs: more questions than answers.
Biochimica et biophysica acta 1998;1400(1-3):195-211.
1998: Scott H Kaufmann; Steven D Gore; Carole B Miller; Richard J Jones; L A Zwelling; E Schneider; PJ Burke; Judith E Karp
Topoisomerase II and the response to antileukemic therapy.
Leukemia & lymphoma 1998;29(3-4):217-37.
1998: Alex A. Adjei; Martin Charron; eric rowinsky; Phyllis A Svingen; J Miller; Joel M Reid; Judith Leopold; Matthew M Ames; Scott H Kaufmann
Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(3):683-91.
1998: Scott H Kaufmann; Judith E Karp; Phyllis A Svingen; Stan Krajewski; PJ Burke; Steven D Gore; John C Reed
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.
Blood 1998;91(3):991-1000.
1998: S Mullany; Phyllis A Svingen; Scott H Kaufmann; Charles Erlichman
Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity.
Cancer chemotherapy and pharmacology 1998;42(5):391-9.
1998: II Budihardjo; G G Poirier; Scott H Kaufmann
Apparent cleavage of poly(ADP-ribose) polymerase in non-apoptotic mouse LTA cells: an artifact of cross-reactive secondary antibody.
Molecular and cellular biochemistry 1998;178(1-2):245-9.
1998: II Budihardjo; Denise L Walker; Phyllis A Svingen; C A Buckwalter; S Desnoyers; S Eckdahl; Girish M Shah; G G Poirier; Joel M Reid; Matthew M Ames; Scott H Kaufmann
6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):117-30.
1997: LM Martins; Peter W Mesner; Timothy J Kottke; Guriqbal S Basi; Sukanto Sinha; jay tung; Phyllis A Svingen; B J Madden; A Takahashi; D J McCormick; William C Earnshaw; Scott H Kaufmann
Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis.
Blood 1997;90(11):4283-96.
1997: Scott H Kaufmann
Resistance to topoisomerase II poisons: is the answer in the promoter?
Leukemia research 1997;21(11-12):1033-6.
1997: Keith C Bible; Scott H Kaufmann
Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration.
Cancer research 1997;57(16):3375-80.
1997: CM Eischen; Timothy J Kottke; LM Martins; Guriqbal S Basi; jay tung; William C Earnshaw; Paul J Leibson; Scott H Kaufmann
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Blood 1997;90(3):935-43.
1997: Alex A. Adjei; II Budihardjo; Eric K Rowinsky; Timothy J Kottke; Phyllis A Svingen; C A Buckwalter; Louise B. Grochow; Ross C Donehower; Scott H Kaufmann
Cytotoxic synergy between pyrazoloacridine (NSC 366140) and cisplatin in vitro: inhibition of platinum-DNA adduct removal.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(5):761-70.
1997: Scott H Kaufmann; Phyllis A Svingen; Steven D Gore; Deborah K Armstrong; Y C Cheng; eric rowinsky
Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells.
Blood 1997;89(6):2098-104.
1997: LM Martins; T Kottke; Peter W Mesner; Guriqbal S Basi; Sukanto Sinha; Normand Frigon; E Tatar; jay tung; K Bryant; A Takahashi; Phyllis A Svingen; B J Madden; D J McCormick; William C Earnshaw; Scott H Kaufmann
Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis.
The Journal of biological chemistry 1997;272(11):7421-30.
1997: Peter W Mesner; II Budihardjo; Scott H Kaufmann
Chemotherapy-induced apoptosis.
Advances in pharmacology (San Diego, Calif.) 1997;41():461-99.
1996: Scott H Kaufmann; Steven D Gore; L Letendre; Phyllis A Svingen; Timothy J Kottke; C A Buckwalter; Richard J Jones; Louise B. Grochow; PJ Burke; Ross C Donehower; Eric K Rowinsky
Factors affecting topotecan sensitivity in human leukemia samples.
Annals of the New York Academy of Sciences 1996;803():128-42.
1996: Eric K Rowinsky; Scott H Kaufmann; Sharyn D Baker; Carole B Miller; SE Sartorius; M K Bowling; Tian Ling Chen; Ross C Donehower; Steven D Gore
A phase I and pharmacological study of topotecan infused over 30 minutes for five days in patients with refractory acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(12):1921-30.
1996: Eric K Rowinsky; Scott H Kaufmann; Sharyn D Baker; Louise B. Grochow; Tian Ling Chen; D Peereboom; M K Bowling; SE Sartorius; David S Ettinger; Arlene A Forastiere; Ross C Donehower
Sequences of topotecan and cisplatin: phase I, pharmacologic, and in vitro studies to examine sequence dependence.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(12):3074-84.
1996: K C Bible; Scott H Kaufmann
Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells.
Cancer research 1996;56(21):4856-61.
1996: Scott H Kaufmann; Judith E Karp; P J Burke; Steven D Gore
Addition of etoposide to initial therapy of adult acute lymphoblastic leukemia: a combined clinical and laboratory study.
Leukemia & lymphoma 1996;23(1-2):71-83.
1996: S Desnoyers; Scott H Kaufmann; G G Poirier
Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors.
Experimental cell research 1996;227(1):146-53.
1996: A Takahashi; Emad S Alnemri; Y A Lazebnik; Teresa Fernandes-Alnemri; G Litwack; Robert D. Moir; R D Goldman; G G Poirier; Scott H Kaufmann; William C Earnshaw
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8395-400.
1996: Scott H Kaufmann; D Peereboom; C A Buckwalter; Phyllis A Svingen; Louise B. Grochow; Ross C Donehower; Eric K Rowinsky
Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines.
Journal of the National Cancer Institute 1996;88(11):734-41.
1996: Diane E McCloskey; Scott H Kaufmann; L J Prestigiacomo; Nancy E Davidson
Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(5):847-54.
1996: Eric K Rowinsky; Louise B. Grochow; SE Sartorius; M K Bowling; Scott H Kaufmann; D Peereboom; Ross C Donehower
Phase I and pharmacologic study of high doses of the topoisomerase I inhibitor topotecan with granulocyte colony-stimulating factor in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(4):1224-35.
1996: S Ubol; S Park; II Budihardjo; S Desnoyers; M H Montrose; G G Poirier; Scott H Kaufmann; Diane E Griffin
Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells.
Journal of virology 1996;70(4):2215-20.
1996: C A Buckwalter; A H Lin; A Tanizawa; Y G Pommier; Y C Cheng; Scott H Kaufmann
RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I.
Cancer research 1996;56(7):1674-81.
1996: Jean-Pierre J Issa; B A Zehnbauer; Curt I Civin; Michael I Collector; Saul J Sharkis; Nancy E Davidson; Scott H Kaufmann; Stephen B Baylin
The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.
Cancer research 1996;56(5):973-77.
1996: C E Carow; M Levenstein; Scott H Kaufmann; J Chen; S Amin; P Rockwell; L Witte; Michael J Borowitz; Curt I Civin; Donald Small
Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias.
Blood 1996;87(3):1089-96.
1995: Scott H Kaufmann; Gregory P Kalemkerian; R Jasti; M Mabry
Effect of v-rasH on sensitivity of NCI-H82 human small cell lung cancer cells to cisplatin, etoposide, and camptothecin.
Biochemical pharmacology 1995;50(12):1987-93.
1995: Y A Lazebnik; A Takahashi; Robert D. Moir; R D Goldman; G G Poirier; Scott H Kaufmann; William C Earnshaw
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9042-6.
1995: Eric K Rowinsky; D A Noe; Louise B. Grochow; S E Sartorious; M K Bowling; Tian Ling Chen; B G Lubejko; Scott H Kaufmann; Ross C Donehower
Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single-dosing and multiple-dosing schedules.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(8):1975-84.
1995: Richard J Jones; Jamie P Barber; Milada S Vala; Michael I Collector; Scott H Kaufmann; S M Ludeman; O Michael Colvin; John Hilton
Assessment of aldehyde dehydrogenase in viable cells.
Blood 1995;85(10):2742-6.
1995: Scott H Kaufmann; Martin Charron; P J Burke; Judith E Karp
Changes in topoisomerase I levels and localization during myeloid maturation in vitro and in vivo.
Cancer research 1995;55(6):1255-60.
1995: Scott H Kaufmann; R Hancock
Topoisomerase II as a target for anticancer chemotherapy.
Acta biochimica Polonica 1995;42(4):381-93.
1995: Y A Lazebnik; A Takahashi; G G Poirier; Scott H Kaufmann; William C Earnshaw
Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells.
Journal of cell science. Supplement 1995;19():41-9.
1994: Deborah K Armstrong; Scott H Kaufmann; YVONNE OTTAVIANO; Y Furuya; J A Buckley; John T Isaacs; Nancy E Davidson
Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells.
Cancer research 1994;54(20):5280-3.
1994: Y A Lazebnik; Scott H Kaufmann; S Desnoyers; G G Poirier; William C Earnshaw
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE.
Nature 1994;371(6495):346-7.
1994: Henry S Friedman; M Eileen Dolan; Scott H Kaufmann; O Michael Colvin; O W Griffith; Robert C Moschel; S Clifford Schold; Darell D Bigner; Francis Ali-Osman
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Cancer research 1994;54(13):3487-93.
1994: Scott H Kaufmann; Judith E Karp; Richard J Jones; Carole B Miller; E Schneider; L A Zwelling; K Cowan; K Wendel; P J Burke
Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia.
Blood 1994;83(2):517-30.
1994: D Peereboom; Martin Charron; Scott H Kaufmann
Topoisomerases in human leukemia.
Advances in pharmacology (San Diego, Calif.) 1994;29B():33-50.
1993: Scott H Kaufmann; S Desnoyers; YVONNE OTTAVIANO; Nancy E Davidson; G G Poirier
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.
Cancer research 1993;53(17):3976-85.
1993: Scott H Kaufmann; J H Shaper
Erasure of western blots after autoradiography or chemiluminescent detection.
Applied biochemistry and biotechnology 1993;38(3):243-55.
1992: Henry S Friedman; O Michael Colvin; Scott H Kaufmann; Susan M Ludeman; Nancy S Bullock; Darell D Bigner; O W Griffith
Cyclophosphamide resistance in medulloblastoma.
Cancer research 1992;52(19):5373-8.
1992: Louise B. Grochow; Eric K Rowinsky; R Johnson; Susan M Ludeman; Scott H Kaufmann; F L McCabe; B R Smith; L Hurowitz; A DeLisa; Ross C Donehower
Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):706-13.
1992: Scott H Kaufmann
Expression of nuclear envelope lamins A and C in human myeloid leukemias.
Cancer research 1992;52(10):2847-53.
1992: C B Hendricks; Eric K Rowinsky; Louise B. Grochow; Ross C Donehower; Scott H Kaufmann
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.
Cancer research 1992;52(8):2268-78.
1992: Eric K Rowinsky; Louise B. Grochow; C B Hendricks; David S Ettinger; Arlene A Forastiere; L A Hurowitz; W P McGuire; SE Sartorius; B G Lubejko; Scott H Kaufmann
Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(4):647-56.
1992: Scott H Kaufmann; J H Shaper
Erasable Western blots.
Methods in molecular biology (Clifton, N.J.) 1992;10():235-46.
1992: Scott H Kaufmann; J H Shaper
Erasable Western blots.
Methods in molecular biology (Clifton, N.J.) 1992;80():235-46.
1991: Scott H Kaufmann; S J McLaughlin; Michael B Kastan; L F Liu; Judith E Karp; P J Burke
Topoisomerase II levels during granulocytic maturation in vitro and in vivo.
Cancer research 1991;51(13):3534-43.
1991: Scott H Kaufmann
Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.
Cancer research 1991;51(4):1129-36.
1991: Scott H Kaufmann; G Brunet; B Talbot; D Lamarr; C Dumas; J H Shaper; G Poirier
Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type.
Experimental cell research 1991;192(2):524-35.
1991: Scott H Kaufmann; M Mabry; R Jasti; Joel H Shaper
Differential expression of nuclear envelope lamins A and C in human lung cancer cell lines.
Cancer research 1991;51(2):581-6.
1991: Scott H Kaufmann
DNA topoisomerases in chemotherapy.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(1):24-7.
1989: Scott H Kaufmann
Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.
Cancer research 1989;49(21):5870-8.
1989: Scott H Kaufmann
Additional members of the rat liver lamin polypeptide family. Structural and immunological characterization.
The Journal of biological chemistry 1989;264(23):13946-55.