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Ann Marie Kaukonen

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Caco-2 Cells

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Johanna Lindkvist; Marja Airaksinen; Ann Marie Kaukonen; Timo Klaukka; Kalle Hoppu
Evolution of paediatric off-label use after new significant medicines become available for adults: a study on triptans in Finnish children 1994-2007.
Sanna Siissalo; Laura Laine; Ari Tolonen; Ann Marie Kaukonen; Moshe Finel; Jouni Hirvonen
Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol.
AI Soikkeli; Cristina Sempio; Ann Marie Kaukonen; Arto Urtti; Jouni Hirvonen; Marjo Yliperttula
Feasibility evaluation of 3 automated cellular drug screening assays on a robotic workstation.

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All Publications

2011: Johanna Lindkvist; Marja Airaksinen; Ann Marie Kaukonen; Timo Klaukka; Kalle Hoppu
Evolution of paediatric off-label use after new significant medicines become available for adults: a study on triptans in Finnish children 1994-2007.
British journal of clinical pharmacology 2011;71(6):929-35.
2010: Sanna Siissalo; Laura Laine; Ari Tolonen; Ann Marie Kaukonen; Moshe Finel; Jouni Hirvonen
Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol.
International journal of pharmaceutics 2010;383(1-2):24-9.
2010: AI Soikkeli; Cristina Sempio; Ann Marie Kaukonen; Arto Urtti; Jouni Hirvonen; Marjo Yliperttula
Feasibility evaluation of 3 automated cellular drug screening assays on a robotic workstation.
Journal of biomolecular screening 2010;15(1):30-41.
2009: Sanna Siissalo; Jenni Hannukainen; Johanna Kolehmainen; Jouni Hirvonen; Ann Marie Kaukonen
A Caco-2 cell based screening method for compounds interacting with MRP2 efflux protein.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;71(2):332-8.
2008: Sanna Siissalo; Hongbo Zhang; Eric Stilgenbauer; Ann Marie Kaukonen; Jouni Hirvonen; Moshe Finel
The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2331-6.
2008: Maija Koljonen; Katja Rousu; Jakub Cierny; Ann Marie Kaukonen; Jouni Hirvonen
Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(2):531-8.
2008: Jarno Salonen; Ann Marie Kaukonen; Jouni Hirvonen; Vesa-Pekka Lehto
Mesoporous silicon in drug delivery applications.
Journal of pharmaceutical sciences 2008;97(2):632-53.
2007: T Limnell; J Riikonen; Jarno Salonen; Ann Marie Kaukonen; Leena Laitinen; Jouni Hirvonen; Vesa-Pekka Lehto
Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles.
International journal of pharmaceutics 2007;343(1-2):141-7.
2007: Henna Vihola; Anna-Kaisa Marttila; Jukka S Pakkanen; Mirja Andersson; Antti Laukkanen; Ann Marie Kaukonen; Heikki Tenhu; Jouni Hirvonen
Cell-polymer interactions of fluorescent polystyrene latex particles coated with thermosensitive poly(N-isopropylacrylamide) and poly(N-vinylcaprolactam) or grafted with poly(ethylene oxide)-macromonomer.
International journal of pharmaceutics 2007;343(1-2):238-46.
2007: Sanna Siissalo; Leena Laitinen; Maija Koljonen; Kati-Sisko Vellonen; Hanna Kortejärvi; Arto Urtti; Jouni Hirvonen; Ann Marie Kaukonen
Effect of cell differentiation and passage number on the expression of efflux proteins in wild type and vinblastine-induced Caco-2 cell lines.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;67(2):548-54.
2007: Teemu Heikkilä; Jarno Salonen; Jaani Tuura; N Kumar; T Salmi; D Yu Murzin; Mohamed S Hamdy; Guido Mul; Leena Laitinen; Ann Marie Kaukonen; Jouni Hirvonen; Vesa-Pekka Lehto
Evaluation of mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 materials as API carriers for oral drug delivery.
Drug delivery 2007;14(6):337-47.
2007: Kaisa Hänninen; Ann Marie Kaukonen; Lasse Murtomäki; Jouni Hirvonen
Mechanistic evaluation of factors affecting compound loading into ion-exchange fibers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;31(5):306-17.
2007: Ann Marie Kaukonen; Leena Laitinen; Jarno Salonen; Jaani Tuura; Teemu Heikkilä; Tarja Limnell; Jouni Hirvonen; Vesa-Pekka Lehto
Enhanced in vitro permeation of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(3):348-56.
2007: Leena Laitinen; Elina Takala; Heikki Vuorela; Pia Vuorela; Ann Marie Kaukonen; Martti Marvola
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(1):135-45.
2007: Teemu Heikkilä; Jarno Salonen; Jaani Tuura; Mohamed S Hamdy; Guido Mul; N Kumar; T Salmi; D Yu Murzin; Leena Laitinen; Ann Marie Kaukonen; Jouni Hirvonen; Vesa-Pekka Lehto
Mesoporous silica material TUD-1 as a drug delivery system.
International journal of pharmaceutics 2007;331(1):133-8.
2007: Kaisa Hänninen; Lasse Murtomäki; Ann Marie Kaukonen; Jouni Hirvonen
The effect of valence on the ion-exchange process: theoretical and experimental aspects on compound binding/release.
Journal of pharmaceutical sciences 2007;96(1):117-31.
2006: Maija Koljonen; Kati S Hakala; Tuula Ahtola-Sätilä; Leena Laitinen; Risto Kostiainen; Tapio Kotiaho; Ann Marie Kaukonen; Jouni Hirvonen
Evaluation of cocktail approach to standardise Caco-2 permeability experiments.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2006;64(3):379-87.
2005: Jarno Salonen; Leena Laitinen; Ann Marie Kaukonen; Jaani Tuura; M Björkqvist; Teemu Heikkilä; K Vähä-Heikkilä; Jouni Hirvonen; Vesa-Pekka Lehto
Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):362-74.
2005: Kaisa Hänninen; Ann Marie Kaukonen; Lasse Murtomäki; Jouni Hirvonen
Effect of ion-exchange fiber structure on the binding and release of model salicylates.
Journal of pharmaceutical sciences 2005;94(8):1772-81.
2005: Julius Sipilä; Harri Nurmi; Ann Marie Kaukonen; Jouni Hirvonen; Jyrki Taskinen; Jari Yli-Kauhaluoma
A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;25(4-5):417-25.
2005: Anna von Bonsdorff-Nikander; Leena Christiansen; Laura Huikko; Anna-Maija Lampi; Vieno Piironen; Jouko Yliruusi; Ann Marie Kaukonen
A comparison of the effect of medium- vs. long-chain triglycerides on the in vitro solubilization of cholesterol and/or phytosterol into mixed micelles.
Lipids 2005;40(2):181-90.
2003: Kati S Hakala; Leena Laitinen; Ann Marie Kaukonen; Jouni Hirvonen; Risto Kostiainen; Tapio Kotiaho
Development of LC/MS/MS methods for cocktail dosed Caco-2 samples using atmospheric pressure photoionization and electrospray ionization.
Analytical chemistry 2003;75(21):5969-77.
2003: Kaisa Hänninen; Ann Marie Kaukonen; Tarja Kankkunen; Jouni Hirvonen
Rate and extent of ion-exchange process: the effect of physico-chemical characteristics of salicylate anions.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(3):449-63.
2003: AM Shawesh; Ann Marie Kaukonen; S Kallioinen; Osmo Antikainen; Jouko Yliruusi
Development of indomethacin Carbopol ETD 2001 gels and the influence of storage time and temperature on their stability.
Die Pharmazie 2003;58(2):130-5.
2003: Leena Laitinen; Heli Kangas; Ann Marie Kaukonen; Kati S Hakala; Tapio Kotiaho; Risto Kostiainen; Jouni Hirvonen
N-in-one permeability studies of heterogeneous sets of compounds across Caco-2 cell monolayers.
Pharmaceutical research 2003;20(2):187-97.
1998: Ann Marie Kaukonen; H Lennernäs; Jukka-Pekka Mannermaa
Water-soluble beta-cyclodextrins in paediatric oral solutions of spironolactone: preclinical evaluation of spironolactone bioavailability from solutions of beta-cyclodextrin derivatives in rats.
The Journal of pharmacy and pharmacology 1998;50(6):611-9.
1998: Ann Marie Kaukonen; Pia Vuorela; Heikki Vuorela; Jukka-Pekka Mannermaa
High-performance liquid chromatography methods for the separation and quantitation of spironolactone and its degradation products in aqueous formulations and of its metabolites in rat serum.
Journal of chromatography. A 1998;797(1-2):271-81.