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Sakari Kauppinen

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TOP 3
Eleonora Leucci; S Obad; A Zriwil; C Bellan; L H Gregersen; K T Jensen; Sakari Kauppinen; L Leoncini; Anders H Lund
Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.
Morten Lindow; Sakari Kauppinen
Discovering the first microRNA-targeted drug.
Maarten F Corsten; Menno de Winther; Marion J J Gijbels; Mark Hazebroek; Erik A L Biessen; Paolo Carai; Peter Carmeliet; Susan L M Coort; Sakari Kauppinen; Morten Lindow; Susanna Obad; Anna Papageorgiou; Blanche Schroen; Frank R M Stassen; Georg Summer; Rick E W van Leeuwen; Wouter Verhesen; Erwin Wijnands; Stephane Heymans
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.

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All Publications

2012: Eleonora Leucci; S Obad; A Zriwil; C Bellan; L H Gregersen; K T Jensen; Sakari Kauppinen; L Leoncini; Anders H Lund
Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.
Oncogene 2012;31(49):5081-9.
2012: Morten Lindow; Sakari Kauppinen
Discovering the first microRNA-targeted drug.
The Journal of cell biology 2012;199(3):407-12.
2012: Maarten F Corsten; Menno de Winther; Marion J J Gijbels; Mark Hazebroek; Erik A L Biessen; Paolo Carai; Peter Carmeliet; Susan L M Coort; Sakari Kauppinen; Morten Lindow; Susanna Obad; Anna Papageorgiou; Blanche Schroen; Frank R M Stassen; Georg Summer; Rick E W van Leeuwen; Wouter Verhesen; Erwin Wijnands; Stephane Heymans
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.
Circulation research 2012;111(4):415-25.
2012: Florian Meisgen; Nikoletta Nagy; Susanna Obad; Andor Pivarcsi; Oliver Broom; Peter C Janson; Sakari Kauppinen; Lajos Kemeny; Mona Ståhle; Tianling Wei; Ning Xu; Eniko Sonkoly
MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.
Experimental dermatology 2012;21(4):312-4.
2012: Stenvang Jan; Morten Lindow; Susanna Obad; Andreas Petri; Sakari Kauppinen
Inhibition of microRNA function by antimiR oligonucleotides.
Silence 2012;3(1):1.
2011: Barry G Garchow; Sakari Kauppinen; Roberto Caricchio; Robert A Eisenberg; Yiu Tak Leung; Susanna Obad; Andreas Petri; Patricia Y Tsao; Oscar Bartulos Encinas; Marianthi Kiriakidou
Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice.
EMBO molecular medicine 2011;3(10):605-15.
2011: Francisco Esteban Nicolas; Helio Pais; Frank Schwach; Sakari Kauppinen; Morten Lindow; Vincent Moulton; Tamas Dalmay
mRNA expression profiling reveals conserved and non-conserved miR-140 targets.
RNA biology 2011;8(4):607-15.
2011: Xi Liu; Lorenzo F Sempere; Yongli Guo; Murray Korc; Sakari Kauppinen; Sarah J Freemantle; Ethan Dmitrovsky
Involvement of microRNAs in lung cancer biology and therapy.
Translational research : the journal of laboratory and clinical medicine 2011;157(4):200-8.
2010: Anders Jacobsen; Anders Krogh; Sakari Kauppinen; Morten Lindow
miRMaid: a unified programming interface for microRNA data resources.
BMC bioinformatics 2010;11():29.
2009: Jesper Worm; Stenvang Jan; Andreas Petri; Klaus Stensgaard Frederiksen; Susanna Obad; Joacim Elmén; Maj Hedtjärn; Ellen Marie Straarup; Jens Bo Hansen; Sakari Kauppinen
Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF.
Nucleic acids research 2009;37(17):5784-92.
2009: Xi Liu; Lorenzo F Sempere; Fabrizio Galimberti; Sarah J Freemantle; Candice Black; Konstantin H Dragnev; Yan Ma; Steven Fiering; Vincent A Memoli; Hua Li; James DiRenzo; Murray Korc; Charles N Cole; Mads Bak; Sakari Kauppinen; Ethan Dmitrovsky
Uncovering growth-suppressive MicroRNAs in lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(4):1177-83.
2009: Andreas Petri; Morten Lindow; Sakari Kauppinen
MicroRNA silencing in primates: towards development of novel therapeutics.
Cancer research 2009;69(2):393-5.
2008: Annette Langkilde; Søren M Kristensen; Leila Lo Leggio; Anne Mølgaard; Jan H Jensen; Andrew R Houk; Jens Christian Navarro Poulsen; Sakari Kauppinen; Sine Larsen
Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 8):851-63.
2008: Joacim Elmén; Morten Lindow; Sylvia Schütz; Matthew Lawrence; Andreas Petri; Susanna Obad; Marie Lindholm; Maj Hedtjärn; Henrik Frydenlund Hansen; Urs Berger; Steven Gullans; Phil Kearney; Peter Sarnow; Ellen Marie Straarup; Sakari Kauppinen
LNA-mediated microRNA silencing in non-human primates.
Nature 2008;452(7189):896-9.
2008: Stenvang Jan; Asli N Silahtaroglu; Morten Lindow; Joacim Elmen; Sakari Kauppinen
The utility of LNA in microRNA-based cancer diagnostics and therapeutics.
Seminars in cancer biology 2008;18(2):89-102.
2008: Mads Bak; Asli N Silahtaroglu; Morten Møller; Mette Christensen; Martin F Rath; Boris Skryabin; Niels Tommerup; Sakari Kauppinen
MicroRNA expression in the adult mouse central nervous system.
RNA (New York, N.Y.) 2008;14(3):432-44.
2008: Joacim Elmén; Morten Lindow; Asli N Silahtaroglu; Mads Bak; Mette Christensen; Allan Lind-Thomsen; Maj Hedtjärn; Jens Bo Hansen; Henrik Frydenlund Hansen; Ellen Marie Straarup; Keith McCullagh; Phil Kearney; Sakari Kauppinen
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.
Nucleic acids research 2008;36(4):1153-62.
2008: Sakari Kauppinen; Zoltán Havelda
Detection of siRNAs and miRNAs.
Methods in molecular biology (Clifton, N.J.) 2008;451():217-27.
2008: Stenvang Jan; Sakari Kauppinen
MicroRNAs as targets for antisense-based therapeutics.
Expert opinion on biological therapy 2008;8(1):59-81.
2007: Lorenzo F Sempere; Mette Christensen; Asli N Silahtaroglu; Mads Bak; Catherine V Heath; Gary Schwartz; Wendy Wells; Sakari Kauppinen; Charles N Cole
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer.
Cancer research 2007;67(24):11612-20.
2007: Nanna Rønbjerg Christoffersen; Asli N Silahtaroglu; Ulf Ørom; Sakari Kauppinen; Anders H Lund
miR-200b mediates post-transcriptional repression of ZFHX1B.
RNA (New York, N.Y.) 2007;13(8):1172-8.
2007: Asli N Silahtaroglu; Dorrit Nolting; Lars Dyrskjøt; Eugene Berezikov; Morten Møller; Niels Tommerup; Sakari Kauppinen
Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification.
Nature protocols 2007;2(10):2520-8.
2006: Ulf Ørom; Sakari Kauppinen; Anders H Lund
LNA-modified oligonucleotides mediate specific inhibition of microRNA function.
Gene 2006;372():137-41.
2006: PETER NELSON; Don A Baldwin; Wigard P Kloosterman; Sakari Kauppinen; Ronald H Plasterk; Zissimos Mourelatos
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain.
RNA (New York, N.Y.) 2006;12(2):187-91.
2006: Wigard P Kloosterman; Erno Wienholds; Ewart de Bruijn; Sakari Kauppinen; Ronald H Plasterk
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes.
Nature methods 2006;3(1):27-9.
2005: Erno Wienholds; Wigard P Kloosterman; Eric A Miska; Ezequiel Alvarez-Saavedra; Eugene Berezikov; Ewart de Bruijn; H Robert Horvitz; Sakari Kauppinen; Ronald H Plasterk
MicroRNA expression in zebrafish embryonic development.
Science (New York, N.Y.) 2005;309(5732):310-1.
2004: Asli N Silahtaroglu; H Pfundheller; Alexei Koshkin; Niels Tommerup; Sakari Kauppinen
LNA-modified oligonucleotides are highly efficient as FISH probes.
Cytogenetic and genome research 2004;107(1-2):32-7.
2002: Renuka Kadirvelraj; Pernille Harris; Jens-Christian Navarro Poulsen; Sakari Kauppinen; Sine Larsen
A stepwise optimization of crystals of rhamnogalacturonan lyase from Aspergillus aculeatus.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 8):1346-9.
2001: Michael Skjøt; Sakari Kauppinen; LV Kofod; C Fuglsang; Markus Pauly; H Dalbøge; L N Andersen
Functional cloning of an endo-arabinanase from Aspergillus aculeatus and its heterologous expression in A. or oryzae and tobacco.
Molecular genetics and genomics : MGG 2001;265(5):913-21.
2000: Anne Mølgaard; Sakari Kauppinen; Sine Larsen
Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases.
Structure (London, England : 1993) 2000;8(4):373-83.
1999: Markus Pauly; L N Andersen; Sakari Kauppinen; LV Kofod; William S York; Peter Albersheim; Alan G Darvill
A xyloglucan-specific endo-beta-1,4-glucanase from Aspergillus aculeatus: expression cloning in yeast, purification and characterization of the recombinant enzyme.
Glycobiology 1999;9(1):93-100.
1998: A Molgaard; J F Petersen; Sakari Kauppinen; H Dalbøge; A H Johnsen; J C Navarro Poulsen; Sine Larsen
Crystallization and preliminary X-ray diffraction studies of the heterogeneously glycosylated enzyme rhamnogalacturonan acetylesterase from Aspergillus aculeatus.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):1026-9.
1997: T N Petersen; Sakari Kauppinen; Sine Larsen
The crystal structure of rhamnogalacturonase A from Aspergillus aculeatus: a right-handed parallel beta helix.
Structure (London, England : 1993) 1997;5(4):533-44.
1997: T N Petersen; Stephan Christgau; LV Kofod; Sakari Kauppinen; A H Johnson; Sine Larsen
Crystallization and preliminary X-ray studies of rhamnogalacturonase A from Aspergillus aculeatus.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 1):105-7.
1996: Stephan Christgau; LV Kofod; T Halkier; L N Andersen; M Hockauf; K Dörreich; H Dalbøge; Sakari Kauppinen
Pectin methyl esterase from Aspergillus aculeatus: expression cloning in yeast and characterization of the recombinant enzyme.
The Biochemical journal 1996;319 ( Pt 3)():705-12.
1996: H Draborg; Stephan Christgau; T Halkier; G Rasmussen; H Dalbøge; Sakari Kauppinen
Secretion of an enzymatically active Trichoderma harzianum endochitinase by Saccharomyces cerevisiae.
Current genetics 1996;29(4):404-9.
1996: Jill Wahleithner; Feng Xu; Kimberly M Brown; SH Brown; Elizabeth J Golightly; T Halkier; Sakari Kauppinen; A Pederson; P Schneider
The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani.
Current genetics 1996;29(4):395-403.
1995: Sakari Kauppinen; Stephan Christgau; LV Kofod; T Halkier; K Dörreich; H Dalbøge
Molecular cloning and characterization of a rhamnogalacturonan acetylesterase from Aspergillus aculeatus. Synergism between rhamnogalacturonan degrading enzymes.
The Journal of biological chemistry 1995;270(45):27172-8.
1995: H Draborg; Sakari Kauppinen; H Dalbøge; Stephan Christgau
Molecular cloning and expression in S. cerevisiae of two exochitinases from Trichoderma harzianum.
Biochemistry and molecular biology international 1995;36(4):781-91.
1994: LV Kofod; Sakari Kauppinen; Stephan Christgau; L N Andersen; H P Heldt-Hansen; K Dörreich; H Dalbøge
Cloning and characterization of two structurally and functionally divergent rhamnogalacturonases from Aspergillus aculeatus.
The Journal of biological chemistry 1994;269(46):29182-9.
1994: Stephan Christgau; Sakari Kauppinen; Jesper Vind; LV Kofod; H Dalbøge
Expression cloning, purification and characterization of a beta-1,4-mannanase from Aspergillus aculeatus.
Biochemistry and molecular biology international 1994;33(5):917-25.