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Kenneth Kaushansky

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Yunyuan V Wang; Allan Balmain; Dannielle Engle; Norma Fox; Kenneth Kaushansky; Kurt Krummel; Mathias Leblanc; Jian-Hua Mao; David Piwnica-Worms; Helen Piwnica-Worms; Kelsey L Tinkum; Geoffrey M Wahl
Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.
Andre Scott Jung; Alexis Kaushansky; Gavin MacBeath; Kenneth Kaushansky
Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling.
Sebastian J Saur; Veena Sangkhae; Amy E Geddis; Kenneth Kaushansky; Ian S Hitchcock
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.

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2011: Yunyuan V Wang; Allan Balmain; Dannielle Engle; Norma Fox; Kenneth Kaushansky; Kurt Krummel; Mathias Leblanc; Jian-Hua Mao; David Piwnica-Worms; Helen Piwnica-Worms; Kelsey L Tinkum; Geoffrey M Wahl
Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.
Genes & development 2011;25(13):1426-38.
2011: Andre Scott Jung; Alexis Kaushansky; Gavin MacBeath; Kenneth Kaushansky
Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling.
Cell cycle (Georgetown, Tex.) 2011;10(11):1838-44.
2010: Sebastian J Saur; Veena Sangkhae; Amy E Geddis; Kenneth Kaushansky; Ian S Hitchcock
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.
Blood 2010;115(6):1254-63.
2009: Kenneth Kaushansky; Helen M Ranney
Thrombopoietin in normal and neoplastic stem cell development.
Best practice & research. Clinical haematology 2009;22(4):495-9.
2009: Kenneth Kaushansky
Molecular mechanisms of thrombopoietin signaling.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():235-8.
2009: Kenneth Kaushansky
Determinants of platelet number and regulation of thrombopoiesis.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2009;():147-52.
2008: Charlene F Barroga; Hang Pham; Kenneth Kaushansky
Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression.
Experimental hematology 2008;36(12):1585-92.
2008: Mie Soda; Karl Willert; Kenneth Kaushansky; Amy E Geddis
Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway.
Cellular signalling 2008;20(12):2317-23.
2008: Ian S Hitchcock; Maximus M Chen; Jennifer R King; Kenneth Kaushansky
YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.
Blood 2008;112(6):2222-31.
2008: Kozue Yoshida; KEITA KIRITO; Hu Yongzhen; Keiya Ozawa; Kenneth Kaushansky; Norio Komatsu
Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species.
International journal of hematology 2008;88(1):43-51.
2008: Bryan McIntosh; Kenneth Kaushansky
Transcriptional regulation of bone marrow thrombopoietin by platelet proteins.
Experimental hematology 2008;36(7):799-806.
2008: Kenneth Kaushansky
Cell expansion and maintenance of stemness.
Blood 2008;111(8):3920-1.
2008: Kenneth Kaushansky
Historical review: megakaryopoiesis and thrombopoiesis.
Blood 2008;111(3):981-6.
2008: Takafumi Nakao; Amy E Geddis; Norma E Fox; Kenneth Kaushansky
PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1).
Cell cycle (Georgetown, Tex.) 2008;7(2):257-66.
2008: Ian S Hitchcock; Norma E Fox; Nicolas Prévost; Katherine Sear; Sanford J Shattil; Kenneth Kaushansky
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.
Blood 2008;111(2):596-604.
2008: KEITA KIRITO; Kumi Sakoe; Daisuke Shinoda; Yoshihisa Takiyama; Kenneth Kaushansky; Norio Komatsu
A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies.
Haematologica 2008;93(1):155-6.
2008: Ernst R Jaffé; Kenneth Kaushansky
The American Society of Hematology: a success at age 50.
Blood 2008;111(1):11-5.
2007: Amy E Geddis; Kenneth Kaushansky
Immunology. The root of platelet production.
Science (New York, N.Y.) 2007;317(5845):1689-91.
2007: Ian S Hitchcock; Kenneth Kaushansky
Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl.
Experimental hematology 2007;35(5):793-801.
2007: Kenneth Kaushansky
The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age.
Best practice & research. Clinical haematology 2007;20(1):5-12.
2007: Amy E Geddis; Norma E Fox; Eugene Tkachenko; Kenneth Kaushansky
Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression.
Cell cycle (Georgetown, Tex.) 2007;6(4):455-60.
2007: Kenneth Kaushansky; Sanford J Shattil
Bloodlines: the importance of mentoring for the future of hematology.
Blood 2007;109(4):1353-4.
2006: Kenneth Kaushansky
Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders.
Cytokine & growth factor reviews 2006;17(6):423-30.
2006: Supantitra Chanprasert; Amy E Geddis; Charlene Barroga; Norma E Fox; Kenneth Kaushansky
Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes.
Cellular signalling 2006;18(8):1212-8.
2006: Kenneth Kaushansky
Lineage-specific hematopoietic growth factors.
The New England journal of medicine 2006;354(19):2034-45.
2006: KEITA KIRITO; Kenneth Kaushansky
Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors.
Current opinion in hematology 2006;13(3):151-6.
2006: Thomas R Coleman; Christof Westenfelder; Florian Tögel; Ying Yang; Zhuma Hu; Leanne Swenson; Henri G D Leuvenink; Rutger J Ploeg; Livius V d'Uscio; Zvonimir S Katusic; Pietro Ghezzi; Adriana Zanetti; Kenneth Kaushansky; Norma E Fox; Anthony Cerami; Michael Brines
Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5965-70.
2006: Amy E Geddis; Kenneth Kaushansky
Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation.
Cell cycle (Georgetown, Tex.) 2006;5(5):538-45.
2006: Chloé C Féral; David M Rose; Jaewon Han; Norma Fox; Gregg J Silverman; Kenneth Kaushansky; Mark H Ginsberg
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site.
The Journal of clinical investigation 2006;116(3):715-23.
2006: Amy E Geddis; Norma E Fox; Kenneth Kaushansky
The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels.
Experimental hematology 2006;34(1):82-6.
2005: Kenneth Kaushansky
The molecular mechanisms that control thrombopoiesis.
The Journal of clinical investigation 2005;115(12):3339-47.
2005: KEITA KIRITO; Kenneth Kaushansky
Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.) 2005;4(12):1729-31.
2005: Kenneth Kaushansky
Thrombopoietin and the hematopoietic stem cell.
Annals of the New York Academy of Sciences 2005;1044():139-41.
2005: Kenneth Kaushansky
On the molecular origins of the chronic myeloproliferative disorders: it all makes sense.
Blood 2005;105(11):4187-90.
2005: KEITA KIRITO; Norma Fox; Norio Komatsu; Kenneth Kaushansky
Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha.
Blood 2005;105(11):4258-63.
2005: Kenneth Kaushansky
On the molecular origins of the chronic myeloproliferative disorders: it all makes sense.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005;():533-7.
2005: Norma E Fox; Kenneth Kaushansky
Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis.
Experimental hematology 2005;33(1):94-9.
2004: Kenneth Kaushansky
ASCI Presidential Address: Mentoring and teaching clinical investigation.
The Journal of clinical investigation 2004;114(8):1165-8.
2004: Amy E Geddis; Kenneth Kaushansky
Megakaryocytes express functional Aurora-B kinase in endomitosis.
Blood 2004;104(4):1017-24.
2004: KEITA KIRITO; Norma Fox; Kenneth Kaushansky
Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells.
Molecular and cellular biology 2004;24(15):6751-62.
2004: Jane Hankins; Paula Naidu; Martha Rieman; Winfred Wang; Kenneth Kaushansky; Carlos Rodriguez-Galindo
Thrombocytosis in an infant with high thrombopoietin concentrations.
Journal of pediatric hematology/oncology 2004;26(2):142-5.
2004: Amy E Geddis; Kenneth Kaushansky
Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production.
Current opinion in pediatrics 2004;16(1):15-22.
2003: Kenneth Kaushansky
Physician-scientists: preparation, opportunities, and national need.
Experimental biology and medicine (Maywood, N.J.) 2003;228(11):1258-60.
2003: Tania Habib; Andrew Nelson; Kenneth Kaushansky
IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses.
The Journal of allergy and clinical immunology 2003;112(6):1033-45.
2003: Amy E Geddis; Kenneth Kaushansky
Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency.
Journal of pediatric hematology/oncology 2003;25(11):919-20; author reply 920.
2003: KEITA KIRITO; Norma Fox; Kenneth Kaushansky
Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells.
Blood 2003;102(9):3172-8.
2003: Kenneth Kaushansky
Thrombopoietin: a tool for understanding thrombopoiesis.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1587-92.
2003: Themis R Kyriakides; Ponlapat Rojnuckarin; Michael A Reidy; Kurt D Hankenson; Thalia Papayannopoulou; Kenneth Kaushansky; Paul Bornstein
Megakaryocytes require thrombospondin-2 for normal platelet formation and function.
Blood 2003;101(10):3915-23.
2003: Kenneth Kaushansky
Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell.
Annals of the New York Academy of Sciences 2003;996():39-43.
2003: Kenneth Kaushansky
Etiology of the myeloproliferative disorders: the role of thrombopoietin.
Seminars in hematology 2003;40(1 Suppl 1):6-9.
2002: Kenneth Kaushansky
Celebrate hematology.
Blood 2002;100(13):4257-8.
2002: Hannah M Linden; Kenneth Kaushansky
The glycan domain of thrombopoietin (TPO) acts in trans to enhance secretion of the hormone and other cytokines.
The Journal of biological chemistry 2002;277(38):35240-7.
2002: Kenneth Kaushansky
Thrombopoietin: from theory to reality.
International journal of hematology 2002;76 Suppl 1():343-5.
2002: Norma Fox; Greg Priestley; Thalia Papayannopoulou; Kenneth Kaushansky
Thrombopoietin expands hematopoietic stem cells after transplantation.
The Journal of clinical investigation 2002;110(3):389-94.
2002: Tania Habib; Shantha Senadheera; Kenneth Weinberg; Kenneth Kaushansky
The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.
Biochemistry 2002;41(27):8725-31.
2002: Jonathan G Drachman; Yoshitaka Miyakawa; Jennifer N Luthi; Debra D Dahlen; Alexa Raney; Amy E Geddis; Kenneth Kaushansky
Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation.
The Journal of biological chemistry 2002;277(26):23544-53.
2002: Kenneth Kaushansky; Norma Fox; Nancy L Lin; W Conrad Liles
Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice.
Blood 2002;99(10):3573-8.
2002: Kenneth Kaushansky; Jonathan G Drachman
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production.
Oncogene 2002;21(21):3359-67.
2002: Shengming Zhao; Karen Zoller; Masayoshi Masuko; Ponlapat Rojnuckarin; Xuexian O Yang; Evan Parganas; Kenneth Kaushansky; James N Ihle; Thalia Papayannopoulou; Dennis M Willerford; Tim Clackson; C Anthony Blau
JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells.
The EMBO journal 2002;21(9):2159-67.
2002: Diana F Sabath; Catherine Lofton-Day; Nancy Lin; Si Lok; Kenneth Kaushansky; Virginia C Broudy
Identification and characterization of an isoform of murine Mpl.
Biochimica et biophysica acta 2002;1574(3):383-6.
2002: Kenneth Kaushansky
Mpl and the hematopoietic stem cell.
Leukemia 2002;16(4):738-9.
2002: Amy E Geddis; Hannah M Linden; Kenneth Kaushansky
Thrombopoietin: a pan-hematopoietic cytokine.
Cytokine & growth factor reviews 2002;13(1):61-73.
2001: Ponlapat Rojnuckarin; Y Miyakawa; Norma E Fox; Jessie Deou; Günter Daum; Kenneth Kaushansky
The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes.
The Journal of biological chemistry 2001;276(44):41014-22.
2001: Amy E Geddis; Norma E Fox; Kenneth Kaushansky
Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors.
The Journal of biological chemistry 2001;276(37):34473-9.
2001: C E Carow; Norma E Fox; Kenneth Kaushansky
Kinetics of endomitosis in primary murine megakaryocytes.
Journal of cellular physiology 2001;188(3):291-303.
2001: Kenneth Kaushansky
Hematopoietic growth factor mimetics.
Annals of the New York Academy of Sciences 2001;938():131-8.
2001: Kenneth Kaushansky
Small molecule mimics of hematopoietic growth factors: improving on Mother Nature?
Leukemia 2001;15(4):673-4.
2001: Y Miyakawa; Ponlapat Rojnuckarin; Tania Habib; Kenneth Kaushansky
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes.
The Journal of biological chemistry 2001;276(4):2494-502.
2001: Kenneth Kaushansky
Glossary of molecular biology terminology.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2001;():522-40.
2001: Ponlapat Rojnuckarin; Kenneth Kaushansky
Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha.
Blood 2001;97(1):154-61.
2000: Q Wang; Y Miyakawa; N Fox; Kenneth Kaushansky
Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1.
Blood 2000;96(6):2093-9.
2000: Hannah M Linden; Kenneth Kaushansky
The glycan domain of thrombopoietin enhances its secretion.
Biochemistry 2000;39(11):3044-51.
2000: Kenneth Kaushansky
Use of thrombopoietic growth factors in acute leukemia.
Leukemia 2000;14(3):505-8.
2000: Diana F Sabath; Nancy Lin; Daniel E Sabath; Kenneth Kaushansky; Virginia C Broudy
Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin.
Cytokine 2000;12(2):127-33.
2000: K Hodohara; N Fujii; N Yamamoto; Kenneth Kaushansky
Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK).
Blood 2000;95(3):769-75.
1999: Ponlapat Rojnuckarin; Jonathan G Drachman; Kenneth Kaushansky
Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis.
Blood 1999;94(4):1273-82.
1999: Kenneth Kaushansky
Thrombopoietin: from theory to reality.
Thrombosis and haemostasis 1999;82(2):312-7.
1999: Diana F Sabath; Kenneth Kaushansky; Virginia C Broudy
Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding.
Blood 1999;94(1):365-7.
1999: Jonathan G Drachman; K M Millett; Kenneth Kaushansky
Thrombopoietin signal transduction requires functional JAK2, not TYK2.
The Journal of biological chemistry 1999;274(19):13480-4.
1999: Kenneth Kaushansky
Thrombopoietin and hematopoietic stem cell development.
Annals of the New York Academy of Sciences 1999;872():314-9.
1999: Kenneth Kaushansky
The enigmatic megakaryocyte gradually reveals its secrets.
BioEssays : news and reviews in molecular, cellular and developmental biology 1999;21(4):353-60.
1999: Jonathan G Drachman; Ponlapat Rojnuckarin; Kenneth Kaushansky
Thrombopoietin signal transduction: studies from cell lines and primary cells.
Methods (San Diego, Calif.) 1999;17(3):238-49.
1998: Kenneth Kaushansky
Thrombopoietin.
The New England journal of medicine 1998;339(11):746-54.
1998: Kenneth Kaushansky
The role of the MPL receptor in myeloproliferative disorders.
Leukemia 1998;12 Suppl 1():S47-50.
1998: L Jin; Noppadol Siritanaratkul; David W Emery; Robert E Richard; Kenneth Kaushansky; Thalia Papayannopoulou; C Anthony Blau
Targeted expansion of genetically modified bone marrow cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8093-7.
1998: Kenneth Kaushansky
Thrombopoietin and the hematopoietic stem cell.
Blood 1998;92(1):1-3.
1998: Virginia C Broudy; Kenneth Kaushansky
Biology of thrombopoietin.
Current opinion in pediatrics 1998;10(1):60-4.
1997: Kenneth Kaushansky
Thrombopoietin: basic biology and clinical promise.
Leukemia 1997;11 Suppl 3():426-7.
1997: Jonathan G Drachman; Kenneth Kaushansky
Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2350-5.
1997: Virginia C Broudy; Nancy L Lin; Diana F Sabath; Thalia Papayannopoulou; Kenneth Kaushansky
Human platelets display high-affinity receptors for thrombopoietin.
Blood 1997;89(6):1896-904.
1997: Kenneth Kaushansky
Thrombopoietin the primary regulator of platelet production.
Trends in endocrinology and metabolism: TEM 1997;8(2):45-50.
1997: Ted Wun; Teresa G Paglieroni; W P Hammond; Kenneth Kaushansky; D C Foster
Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro.
American journal of hematology 1997;54(3):225-32.
1997: Jonathan G Drachman; Diana F Sabath; Norma E Fox; Kenneth Kaushansky
Thrombopoietin signal transduction in purified murine megakaryocytes.
Blood 1997;89(2):483-92.
1997: Kenneth Kaushansky
Thrombopoietin: more than a lineage-specific megakaryocyte growth factor.
Stem cells (Dayton, Ohio) 1997;15 Suppl 1():97-102; discussion 102-3.
1997: Kenneth Kaushansky
Thrombopoietin: understanding and manipulating platelet production.
Annual review of medicine 1997;48():1-11.
1996: Kenneth Kaushansky
Megakaryocytes their precursors and their progeny.
Trends in cardiovascular medicine 1996;6(8):261-4.
1996: A Grossmann; J Lenox; T A Deisher; H P Ren; J M Humes; Kenneth Kaushansky; K H Sprugel
Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice.
Blood 1996;88(9):3363-70.
1996: Kenneth Kaushansky
Thrombopoietin: in vitro predictions, in vivo realities.
American journal of hematology 1996;53(3):188-91.
1996: Virginia C Broudy; Nancy L Lin; N Fox; T Taga; M Saito; Kenneth Kaushansky
Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit.
Blood 1996;88(6):2026-32.
1996: A Grossmann; J Lenox; H P Ren; J M Humes; J W Forstrom; Kenneth Kaushansky; K H Sprugel
Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.
Experimental hematology 1996;24(10):1238-46.
1996: J V Matous; K Langley; Kenneth Kaushansky
Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody.
Blood 1996;88(2):437-44.
1996: E Sitnicka; N Lin; Gregory V Priestley; N Fox; Virginia C Broudy; Norman S Wolf; Kenneth Kaushansky
The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells.
Blood 1996;87(12):4998-5005.
1996: Aly Karsan; E Yee; Kenneth Kaushansky; John M Harlan
Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.
Blood 1996;87(8):3089-96.
1996: Kenneth Kaushansky
The thrombocytopenia of cancer. Prospects for effective cytokine therapy.
Hematology/oncology clinics of North America 1996;10(2):431-55.
1996: Kenneth Kaushansky
Thrombopoietin: biological and preclinical properties.
Leukemia 1996;10 Suppl 1():S46-8.
1996: Thalia Papayannopoulou; M Brice; D Farrer; Kenneth Kaushansky
Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy.
Experimental hematology 1996;24(5):660-9.
1996: Kenneth Kaushansky
Thrombopoietin and platelet development.
The Western journal of medicine 1996;164(3):209-11.
1996: Kenneth Kaushansky; C O'Rork; S G Shoemaker; J McCarty
The regulation of GM-CSF is dependent on a complex interplay of multiple nuclear proteins.
Molecular immunology 1996;33(4-5):461-70.
1996: Kenneth Kaushansky; N Lin; A Grossmann; J Humes; K H Sprugel; Virginia C Broudy
Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice.
Experimental hematology 1996;24(2):265-9.
1996: Kenneth Kaushansky; Virginia C Broudy; E Sitnicka; Catherine Lofton-Day; A Grossmann; K Sprugel
Do the preclinical effects of thrombopoietin correlate with its in vitro properties?
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():108-11.
1995: J M McCarty; K H Sprugel; N E Fox; Daniel E Sabath; Kenneth Kaushansky
Murine thrombopoietin mRNA levels are modulated by platelet count.
Blood 1995;86(10):3668-75.
1995: Kenneth Kaushansky; Virginia C Broudy; A Grossmann; J Humes; N Lin; H P Ren; M C Bailey; Thalia Papayannopoulou; J W Forstrom; K H Sprugel
Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.
The Journal of clinical investigation 1995;96(3):1683-7.
1995: Kenneth Kaushansky
Thrombopoietin: the primary regulator of platelet production.
Blood 1995;86(2):419-31.
1995: Kenneth Kaushansky
Thrombopoietin: the primary regulator of megakaryocyte and platelet production.
Thrombosis and haemostasis 1995;74(1):521-5.
1995: Kenneth Kaushansky
Thrombopoietin: basic biology, clinical promise.
International journal of hematology 1995;62(1):7-15.
1995: Kenneth Kaushansky
Physiology and preclinical studies of thrombopoietin.
Current opinion in hematology 1995;2(3):172-6.
1995: Virginia C Broudy; Kenneth Kaushansky
Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production.
Journal of leukocyte biology 1995;57(5):719-25.
1995: Kenneth Kaushansky; Virginia C Broudy; N Lin; M J Jorgensen; J McCarty; N Fox; D Zucker-Franklin; Catherine Lofton-Day
Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3234-8.
1995: Virginia C Broudy; Nancy L Lin; Kenneth Kaushansky
Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro.
Blood 1995;85(7):1719-26.
1995: Jonathan G Drachman; James D Griffin; Kenneth Kaushansky
The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
The Journal of biological chemistry 1995;270(10):4979-82.
1995: Jonathan G Drachman; Kenneth Kaushansky
Structure and function of the cytokine receptor superfamily.
Current opinion in hematology 1995;2(1):22-8.
1994: Kenneth Kaushansky; Si Lok; R D Holly; Virginia C Broudy; N Lin; M C Bailey; J W Forstrom; M M Buddle; P J Oort; F S Hagen
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin.
Nature 1994;369(6481):568-71.
1994: Si Lok; Kenneth Kaushansky; R D Holly; JL Kuijper; Catherine Lofton-Day; P J Oort; Francis J Grant; M D Heipel; S K Burkhead; J M Kramer
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.
Nature 1994;369(6481):565-8.
1994: Kenneth Kaushansky; S G Shoemaker; C A O'Rork; J M McCarty
Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1812-20.
1994: Kenneth Kaushansky
The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():91-6; discussion 96-7.
1993: Kenneth Kaushansky; P A Karplus
Hematopoietic growth factors: understanding functional diversity in structural terms.
Blood 1993;82(11):3229-40.
1992: Kenneth Kaushansky; S G Shoemaker; Virginia C Broudy; Nancy L Lin; J V Matous; E M Alderman; J D Aghajanian; P J Szklut; R E VanDyke; M K Pearce
Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3.
The Journal of clinical investigation 1992;90(5):1879-88.
1992: Kenneth Kaushansky; Jose A Lopez; C B Brown
Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells.
Biochemistry 1992;31(6):1881-6.
1992: Kenneth Kaushansky
Structure-function relationships of the hematopoietic growth factors.
Proteins 1992;12(1):1-9.
1991: Robert Hromas; S J Collins; Dennis D Hickstein; W Raskind; L L Deaven; P O'Hara; F S Hagen; Kenneth Kaushansky
A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells.
The Journal of biological chemistry 1991;266(22):14183-7.
1990: S G Shoemaker; R Hromas; Kenneth Kaushansky
Transcriptional regulation of interleukin 3 gene expression in T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9650-4.
1990: Virginia C Broudy; Kenneth Kaushansky; S G Shoemaker; B B Aggarwal; J W Adamson
Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3789-94.
1990: C B Brown; C E Hart; D M Curtis; M C Bailey; Kenneth Kaushansky
Two neutralizing monoclonal antibodies against human granulocyte-macrophage colony-stimulating factor recognize the receptor binding domain of the molecule.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2184-9.
1990: Kenneth Kaushansky; C B Brown; P J O'Hara
Molecular modeling of human granulocyte-macrophage colony-stimulating factor.
International journal of cell cloning 1990;8 Suppl 1():26-33; discussion 33-4.
1989: Kenneth Kaushansky
Control of granulocyte-macrophage colony-stimulating factor production in normal endothelial cells by positive and negative regulatory elements.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(8):2525-9.
1989: Kenneth Kaushansky; J E Miller; D R Morris; C B Wilson; W P Hammond
The role of lymphocytes and monocytes in hematopoietic growth factor production by peripheral blood mononuclear cells.
Cellular immunology 1989;122(1):62-70.
1989: MY Lee; Kenneth Kaushansky; S A Judkins; J L Lottsfeldt; A Waheed; R K Shadduck
Mechanisms of tumor-induced neutrophilia: constitutive production of colony-stimulating factors and their synergistic actions.
Blood 1989;74(1):115-22.
1989: Kenneth Kaushansky; S G Shoemaker; S Alfaro; C Brown
Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1213-7.
1989: J Nemunaitis; D F Andrews; C Crittenden; Kenneth Kaushansky; J W Singer
Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors.
The Journal of clinical investigation 1989;83(2):593-601.
1989: G Migliaccio; Anna Rita Migliaccio; Kenneth Kaushansky; J W Adamson
Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions.
Experimental hematology 1989;17(2):110-5.
1988: Kenneth Kaushansky; Virginia C Broudy; John M Harlan; J W Adamson
Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3410-5.
1988: Kenneth Kaushansky; N Lin; J W Adamson
Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.
The Journal of clinical investigation 1988;81(1):92-7.
1987: Kenneth Kaushansky; P J O'Hara; CE Hart; J W Forstrom; F S Hagen
Role of carbohydrate in the function of human granulocyte-macrophage colony-stimulating factor.
Biochemistry 1987;26(15):4861-7.
1987: Kenneth Kaushansky
The molecular biology of the colony-stimulating factors.
Blood cells 1987;13(1-2):3-15.