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Brian Kavanagh

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Maurizio Cereda; Clifford S Deutschman; Kiarash Emami; Masaru Ishii; Stephen Kadlecek; Brian P Kavanagh; Nicholas N Kuzma; Puttisarn Mongkolwisetwara; Stephen Pickup; Harrilla Profka; Yi Xin; Rahim R Rizi
Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs.
Satoko Uematsu; Doreen Engelberts; Gail Otulakowski; Vanya Peltekova; Martin Post; Brian P Kavanagh
Dissociation of inflammatory mediators and function: experimental lung injury in nonpulmonary sepsis.
Gary Peng; Todd Van Vliet; Crystal Kantores; Brian P Kavanagh; Patrick J McNamara; Jaques Belik; Doreen Engelberts; Masahiro Enomoto; Julijana Ivanovska; Amish Jain; Robert P Jankov
Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats.

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All Publications

2013: Maurizio Cereda; Clifford S Deutschman; Kiarash Emami; Masaru Ishii; Stephen Kadlecek; Brian P Kavanagh; Nicholas N Kuzma; Puttisarn Mongkolwisetwara; Stephen Pickup; Harrilla Profka; Yi Xin; Rahim R Rizi
Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs.
Critical care medicine 2013;41(2):527-35.
2013: Satoko Uematsu; Doreen Engelberts; Gail Otulakowski; Vanya Peltekova; Martin Post; Brian P Kavanagh
Dissociation of inflammatory mediators and function: experimental lung injury in nonpulmonary sepsis.
Critical care medicine 2013;41(1):151-8.
2012: Gary Peng; Todd Van Vliet; Crystal Kantores; Brian P Kavanagh; Patrick J McNamara; Jaques Belik; Doreen Engelberts; Masahiro Enomoto; Julijana Ivanovska; Amish Jain; Robert P Jankov
Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats.
American journal of physiology. Heart and circulatory physiology 2012;302(12):H2599-611.
2012: Doreen Engelberts; Stephen H Loring; Atul Malhotra; George P Topulos; James P Butler; Brian P Kavanagh
Relative effects of negative versus positive pressure ventilation depend on applied conditions.
Intensive care medicine 2012;38(5):879-85.
2011: Gail Otulakowski; Brian P Kavanagh
Hypercapnia in acute illness: sometimes good, sometimes not.
Critical care medicine 2011;39(6):1581-2.
2011: Thomas Jaecklin; Doreen Engelberts; Gail Otulakowski; Hugh O'Brodovich; Martin Post; Brian P Kavanagh
Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2011;300(4):L648-58.
2011: Takehiro Niitsu; Shinya Tsuchida; Vanya Peltekova; Doreen Engelberts; Ian Copland; Gail Otulakowski; Martin Post; Brian P Kavanagh
Cyclooxygenase inhibition in ventilator-induced lung injury.
Anesthesia and analgesia 2011;112(1):143-9.
2010: Brian P Kavanagh; Karen C McCowen
Clinical practice. Glycemic control in the ICU.
The New England journal of medicine 2010;363(26):2540-6.
2010: Emily Z Xu; Crystal Kantores; Julijana Ivanovska; Doreen Engelberts; Brian P Kavanagh; Patrick J McNamara; Robert P Jankov
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
American journal of physiology. Heart and circulatory physiology 2010;299(6):H1854-64.
2010: Gail Otulakowski; Brian P Kavanagh
Hydrogen sulfide in lung injury: therapeutic hope from a toxic gas?
Anesthesiology 2010;113(1):4-6.
2010: Michelle Duggan; Brian P Kavanagh
Perioperative modifications of respiratory function.
Best practice & research. Clinical anaesthesiology 2010;24(2):145-55.
2010: Thomas Jaecklin; Gail Otulakowski; Brian P Kavanagh
Do soluble mediators cause ventilator-induced lung injury and multi-organ failure?
Intensive care medicine 2010;36(5):750-7.
2010: Vanya Peltekova; Doreen Engelberts; Gail Otulakowski; Satoko Uematsu; Martin Post; Brian P Kavanagh
Hypercapnic acidosis in ventilator-induced lung injury.
Intensive care medicine 2010;36(5):869-78.
2010: Nicola Ngiam; Vanya Peltekova; Doreen Engelberts; Gail Otulakowski; Martin Post; Brian P Kavanagh
Early growth response-1 worsens ventilator-induced lung injury by up-regulating prostanoid synthesis.
American journal of respiratory and critical care medicine 2010;181(9):947-56.
2009: Azhar Masood; Man Yi; Mandy Lau; Rosetta Belcastro; Samuel Shek; Jingyi Pan; Crystal Kantores; Patrick J McNamara; Brian P Kavanagh; Jaques Belik; Robert P Jankov; A Keith Tanswell
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats.
American journal of physiology. Lung cellular and molecular physiology 2009;297(5):L920-30.
2009: Conán L McCaul; Alik Kornecki; Doreen Engelberts; Patrick McNamara; Brian P Kavanagh
Positive end-expiratory pressure improves survival in a rodent model of cardiopulmonary resuscitation using high-dose epinephrine.
Anesthesia and analgesia 2009;109(4):1202-8.
2009: Brian P Kavanagh
The GRADE system for rating clinical guidelines.
PLoS medicine 2009;6(9):e1000094.
2009: Emma Helm; Omid Talakoub; Francesco Grasso; Doreen Engelberts; Javad Alirezaie; Brian P Kavanagh; Paul Babyn
Use of dynamic CT in acute respiratory distress syndrome (ARDS) with comparison of positive and negative pressure ventilation.
European radiology 2009;19(1):50-7.
2008: Brian P Kavanagh
Perioperative atelectasis.
Minerva anestesiologica 2008;74(6):285-7.
2008: Alik Kornecki; Doreen Engelberts; Patrick McNamara; Robert P Jankov; Conán L McCaul; Cameron Ackerley; Martin Post; Brian P Kavanagh
Vascular remodeling protects against ventilator-induced lung injury in the in vivo rat.
Anesthesiology 2008;108(6):1047-54.
2008: Francesco Grasso; Doreen Engelberts; Emma Helm; Helena Frndova; Steven Jarvis; Omid Talakoub; Colin McKerlie; Paul Babyn; Martin Post; Brian P Kavanagh
Negative-pressure ventilation: better oxygenation and less lung injury.
American journal of respiratory and critical care medicine 2008;177(4):412-8.
2008: Patrick J McNamara; Prashanth Murthy; Crystal Kantores; Lilian Teixeira; Doreen Engelberts; Todd van Vliet; Brian P Kavanagh; Robert P Jankov
Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide.
American journal of physiology. Lung cellular and molecular physiology 2008;294(2):L205-13.
2007: Nicola Ngiam; Martin Post; Brian P Kavanagh
Early growth response factor-1 in acute lung injury.
American journal of physiology. Lung cellular and molecular physiology 2007;293(5):L1089-91.
2007: Waleed H Albuali; Ram N Singh; Douglas D Fraser; Jamie A Seabrook; Brian P Kavanagh; Christopher S Parshuram; Alik Kornecki
Have changes in ventilation practice improved outcome in children with acute lung injury?
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2007;8(4):324-30.
2007: Michelle Duggan; Brian P Kavanagh
Atelectasis in the perioperative patient.
Current opinion in anaesthesiology 2007;20(1):37-42.
2006: Crystal Kantores; Patrick J McNamara; Lilian Teixeira; Doreen Engelberts; Prashanth Murthy; Brian P Kavanagh; Robert P Jankov
Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat.
American journal of physiology. Lung cellular and molecular physiology 2006;291(5):L912-22.
2006: Shinya Tsuchida; Doreen Engelberts; Vanya Peltekova; Natalie Hopkins; Helena Frndova; Paul Babyn; Colin McKerlie; Martin Post; Paul McLoughlin; Brian P Kavanagh
Atelectasis causes alveolar injury in nonatelectatic lung regions.
American journal of respiratory and critical care medicine 2006;174(3):279-89.
2006: Brian P Kavanagh; John G Laffey
Hypercapnia: permissive and therapeutic.
Minerva anestesiologica 2006;72(6):567-76.
2006: Conán L McCaul; Patrick J McNamara; Doreen Engelberts; Gregory J Wilson; Alexander D Romaschin; Andrew N Redington; Brian P Kavanagh
Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model.
Anesthesia and analgesia 2006;102(2):542-8.
2006: Conán L McCaul; Patrick McNamara; Doreen Engelberts; Cameron Slorach; Lisa K Hornberger; Brian P Kavanagh
The effect of global hypoxia on myocardial function after successful cardiopulmonary resuscitation in a laboratory model.
Resuscitation 2006;68(2):267-75.
2005: Conán L McCaul; Donal Harney; Margaret Ryan; Ciaran Moran; Brian P Kavanagh; John Boylan
Airway management in the lateral position: a randomized controlled trial.
Anesthesia and analgesia 2005;101(4):1221-5, table of contents.
2005: Shinya Tsuchida; Doreen Engelberts; Matthias Roth; Colin McKerlie; Martin Post; Brian P Kavanagh
Continuous positive airway pressure causes lung injury in a model of sepsis.
American journal of physiology. Lung cellular and molecular physiology 2005;289(4):L554-64.
2005: Michelle Duggan; Patrick J McNamara; Doreen Engelberts; Cecil R Pace-Asciak; Paul Babyn; Martin Post; Brian P Kavanagh
Oxygen attenuates atelectasis-induced injury in the in vivo rat lung.
Anesthesiology 2005;103(3):522-31.
2005: Brian P Kavanagh; L Joanne Meyer
Normalizing physiological variables in acute illness: five reasons for caution.
Intensive care medicine 2005;31(9):1161-7.
2005: Sandra Pong; Winnie Seto; Mohamed Abdolell; Angela Trope; Karen Wong; Joann Herridge; Elizabeth Harvey; Brian P Kavanagh
12-hour versus 24-hour creatinine clearance in critically ill pediatric patients.
Pediatric research 2005;58(1):83-8.
2005: Michelle Duggan; Brian P Kavanagh
Pulmonary atelectasis: a pathogenic perioperative entity.
Anesthesiology 2005;102(4):838-54.
2005: Alik Kornecki; Shinya Tsuchida; Hari Kumar Ondiveeran; Doreen Engelberts; Helena Frndova; A Keith Tanswell; Martin Post; Colin McKerlie; Jaques Belik; Alison E Fox-Robichaud; Brian P Kavanagh
Lung development and susceptibility to ventilator-induced lung injury.
American journal of respiratory and critical care medicine 2005;171(7):743-52.
2005: Michelle Duggan; Doreen Engelberts; Robert P Jankov; Jordan M A Worrall; Rong Qu; Gregory M T Hare; A Keith Tanswell; J Brendan Mullen; Brian P Kavanagh
Hypocapnia attenuates mesenteric ischemia-reperfusion injury in a rat model.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2005;52(3):262-8.
2004: Christopher S Parshuram; Brian P Kavanagh
Positive clinical trials: understand the control group before implementing the result.
American journal of respiratory and critical care medicine 2004;170(3):223-6.
2004: Francisco Martinez; James Lewis; Ian B Copland; Doreen Engelberts; Brian P Kavanagh; Martin Post; Samuel Schurch; Jaques Belik
Mechanical ventilation effect on surfactant content, function, and lung compliance in the newborn rat.
Pediatric research 2004;56(1):19-25.
2004: Ian B Copland; Francisco Martinez; Brian P Kavanagh; Doreen Engelberts; Colin McKerlie; Jaques Belik; Martin Post
High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung.
American journal of respiratory and critical care medicine 2004;169(6):739-48.
2004: John G Laffey; Donall O'Croinin; Paul McLoughlin; Brian P Kavanagh
Permissive hypercapnia--role in protective lung ventilatory strategies.
Intensive care medicine 2004;30(3):347-56.
2004: Sharadindu Rai; Doreen Engelberts; John G Laffey; Charles W Frevert; Osamu Kajikawa; Thomas R Martin; Martin Post; Brian P Kavanagh
Therapeutic hypercapnia is not protective in the in vivo surfactant-depleted rabbit lung.
Pediatric research 2004;55(1):42-9.
2003: Gregory M T Hare; Brian P Kavanagh; C David Mazer; Kathryn M Hum; Steve Y Kim; Carla Coackley; Aiala Barr; Andrew J Baker
Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2003;50(10):1061-8.
2003: John G Laffey; Robert P Jankov; Doreen Engelberts; A Keith Tanswell; Martin Post; Thomas F Lindsay; J Brendan Mullen; Alexander D Romaschin; Derek Stephens; Colin McKerlie; Brian P Kavanagh
Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury.
American journal of respiratory and critical care medicine 2003;168(11):1383-90.
2003: John G Laffey; Doreen Engelberts; Michelle Duggan; Ruud Veldhuizen; James F Lewis; Brian P Kavanagh
Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation.
Critical care medicine 2003;31(11):2634-40.
2003: Ian B Copland; Brian P Kavanagh; Doreen Engelberts; Colin McKerlie; Jaques Belik; Martin Post
Early changes in lung gene expression due to high tidal volume.
American journal of respiratory and critical care medicine 2003;168(9):1051-9.
2003: Michelle Duggan; Conán L McCaul; Patrick J McNamara; Doreen Engelberts; Cameron Ackerley; Brian P Kavanagh
Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs.
American journal of respiratory and critical care medicine 2003;167(12):1633-40.
2002: Galia Grisaru-Soen; John G Coles; Brian P Kavanagh; Sandra R Arnold
Rupture of the common carotid artery after extracorporeal membrane oxygenation.
The Annals of thoracic surgery 2002;74(5):1697-8.
2002: John G Laffey; Brian P Kavanagh
Hypocapnia.
The New England journal of medicine 2002;347(1):43-53.
2000: John G Laffey; M Tanaka; Doreen Engelberts; Xiaoping Luo; S Yuan; A Keith Tanswell; Martin Post; Thomas F Lindsay; Brian P Kavanagh
Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion.
American journal of respiratory and critical care medicine 2000;162(6):2287-94.
2000: John G Laffey; Brian P Kavanagh
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury.
The New England journal of medicine 2000;343(11):812; author reply 813-4.
2000: John G Laffey; Doreen Engelberts; Brian P Kavanagh
Injurious effects of hypocapnic alkalosis in the isolated lung.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):399-405.
2000: Damian B Murphy; N Cregg; L Tremblay; Doreen Engelberts; John G Laffey; Arthur Slutsky; Alexander D Romaschin; Brian P Kavanagh
Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin.
American journal of respiratory and critical care medicine 2000;162(1):27-33.
2000: John G Laffey; Brian P Kavanagh
Biological effects of hypercapnia.
Intensive care medicine 2000;26(1):133-8.
2000: John G Laffey; Doreen Engelberts; Brian P Kavanagh
Buffering hypercapnic acidosis worsens acute lung injury.
American journal of respiratory and critical care medicine 2000;161(1):141-6.
1999: John G Laffey; Brian P Kavanagh
Carbon dioxide and the critically ill--too little of a good thing?
Lancet 1999;354(9186):1283-6.
1999: Brian P Kavanagh
Anemia, hypoxia and hypercapnia thresholds. Lessons from physiological limits in critically ill patients.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1999;46(5 Pt 2):R145-55.
1999: O Nishida; R Arellano; Davy Cheng; WC DeMajo; Brian P Kavanagh
Gas exchange and hemodynamics in experimental pleural effusion.
Critical care medicine 1999;27(3):583-7.
1998: K Shibata; N Cregg; Doreen Engelberts; A Takeuchi; Ludwik Fedorko; Brian P Kavanagh
Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase.
American journal of respiratory and critical care medicine 1998;158(5 Pt 1):1578-84.
1998: John Boylan; Joel Katz; Brian P Kavanagh; J R Klinck; Davy Cheng; WC DeMajo; Paul M Walker; K Wayne Johnston; AN Sandler
Epidural bupivacaine-morphine analgesia versus patient-controlled analgesia following abdominal aortic surgery: analgesic, respiratory, and myocardial effects.
Anesthesiology 1998;89(3):585-93.
1997: P M Saccomanno; Brian P Kavanagh; Davy Cheng; Joel Katz; AN Sandler
Comparison of lorazepam alone vs lorazepam, morphine, and perphenazine for cardiac premedication.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1997;44(2):146-53.
1996: Joel Katz; M Clairoux; C Redahan; Brian P Kavanagh; S Carroll; H Nierenberg; M Jackson; J Beattie; A Taddio; AN Sandler
High dose alfentanil pre-empts pain after abdominal hysterectomy.
Pain 1996;68(1):109-18.
1994: Joel Katz; M Clairoux; Brian P Kavanagh; S Roger; H Nierenberg; C Redahan; AN Sandler
Pre-emptive lumbar epidural anaesthesia reduces postoperative pain and patient-controlled morphine consumption after lower abdominal surgery.
Pain 1994;59(3):395-403.
1994: Brian P Kavanagh; Joel Katz; AN Sandler; H Nierenberg; S Roger; John Boylan; A K Laws
Multimodal analgesia before thoracic surgery does not reduce postoperative pain.
British journal of anaesthesia 1994;73(2):184-9.
1994: M Friedlander; A Sandler; Brian P Kavanagh; T Winton; J Benumof
Is hypoxic pulmonary vasoconstriction important during single lung ventilation in the lateral decubitus position?
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1994;41(1):26-30.
1993: Brian P Kavanagh; Davy Cheng; AN Sandler; Frances Chung; S Lawson; D Ong
Supplemental oxygen does not reduce myocardial ischemia in premedicated patients with critical coronary artery disease.
Anesthesia and analgesia 1993;76(5):950-6.
1993: Joel Katz; Brian P Kavanagh; M Clairoux; AN Sandler
Pre-emptive analgesia.
British journal of anaesthesia 1993;70(3):378-9.
1992: Joel Katz; Brian P Kavanagh; AN Sandler; H Nierenberg; John Boylan; M Friedlander; B F Shaw
Preemptive analgesia. Clinical evidence of neuroplasticity contributing to postoperative pain.
Anesthesiology 1992;77(3):439-46.
1992: Brian P Kavanagh; AN Sandler; K E Turner; V Wick; S Lawson
Use of end-tidal PCO2 and transcutaneous PCO2 as noninvasive measurement of arterial PCO2 in extubated patients recovering from general anesthesia.
Journal of clinical monitoring 1992;8(3):226-30.