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Kathryn Kavanagh

Research Profile

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X Ray Crystallography

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Publications

TOP 3
Thomas Eixelsberger; Kathryn L Kavanagh; Lothar Brecker; Michael Brunsteiner; Sigrid Egger; Udo Oppermann; Sabine Sykora; Bernd Nidetzky
Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid.
Sigrid Egger; Kathryn L Kavanagh; Mario Klimacek; Apirat Chaikuad; Udo Oppermann; Bernd Nidetzky
Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.
Apirat Chaikuad; Antonio De Riso; Kathryn L Kavanagh; Udo Oppermann; Ewa S Pilka; Catherine Vénien-Bryan; Frank von Delft; Wyatt W Yue
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

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All Publications

2012: Thomas Eixelsberger; Kathryn L Kavanagh; Lothar Brecker; Michael Brunsteiner; Sigrid Egger; Udo Oppermann; Sabine Sykora; Bernd Nidetzky
Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid.
The Journal of biological chemistry 2012;287(37):31349-58.
2012: Sigrid Egger; Kathryn L Kavanagh; Mario Klimacek; Apirat Chaikuad; Udo Oppermann; Bernd Nidetzky
Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.
The Journal of biological chemistry 2012;287(3):2119-29.
2012: Apirat Chaikuad; Antonio De Riso; Kathryn L Kavanagh; Udo Oppermann; Ewa S Pilka; Catherine Vénien-Bryan; Frank von Delft; Wyatt W Yue
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.
BMC structural biology 2012;12():14.
2011: Sigrid Egger; Kathryn L Kavanagh; Apirat Chaikuad; Udo Oppermann; Bernd Nidetzky
Structure and mechanism of human UDP-glucose 6-dehydrogenase.
The Journal of biological chemistry 2011;286(27):23877-87.
2010: Sigrid Egger; Apirat Chaikuad; Kathryn L Kavanagh; Udo Oppermann; Bernd Nidetzky
UDP-glucose dehydrogenase: structure and function of a potential drug target.
Biochemical Society transactions 2010;38(5):1378-85.
2005: Barbara Petschacher; Stefan Leitgeb; Kathryn L Kavanagh; David K Wilson; Bernd Nidetzky
The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography.
The Biochemical journal 2005;385(Pt 1):75-83.
2004: Regina Kratzer; Kathryn L Kavanagh; David K Wilson; Bernd Nidetzky
Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant.
Biochemistry 2004;43(17):4944-54.
2004: Kathryn L Kavanagh; Robert A Elling; David K Wilson
Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use.
Biochemistry 2004;43(4):879-89.
2003: Mario Klimacek; Kathryn L Kavanagh; David K Wilson; Bernd Nidetzky
On the role of Brønsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase.
The Biochemical journal 2003;375(Pt 1):141-9.
2003: Kathryn L Kavanagh; Mario Klimacek; Bernd Nidetzky; David K Wilson
Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases.
The Biochemical journal 2003;373(Pt 2):319-26.
2003: Mario Klimacek; Kathryn L Kavanagh; David K Wilson; Bernd Nidetzky
Pseudomonas fluorescens mannitol 2-dehydrogenase and the family of polyol-specific long-chain dehydrogenases/reductases: sequence-based classification and analysis of structure-function relationships.
Chemico-biological interactions 2003;143-144():559-82.
2003: Kathryn L Kavanagh; Mario Klimacek; Bernd Nidetzky; David K Wilson
Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase: evidence for a very divergent long-chain dehydrogenase family.
Chemico-biological interactions 2003;143-144():551-8.
2003: Mario Klimacek; Franz Wührer; Kathryn L Kavanagh; David K Wilson; Bernd Nidetzky
Altering dimer contacts in xylose reductase from Candida tenuis by site-directed mutagenesis: structural and functional properties of R180A mutant.
Chemico-biological interactions 2003;143-144():523-32.
2003: David K Wilson; Kathryn L Kavanagh; Mario Klimacek; Bernd Nidetzky
The xylose reductase (AKR2B5) structure: homology and divergence from other aldo-keto reductases and opportunities for protein engineering.
Chemico-biological interactions 2003;143-144():515-21.
2002: Kathryn L Kavanagh; Mario Klimacek; Bernd Nidetzky; David K Wilson
Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism.
The Journal of biological chemistry 2002;277(45):43433-42.
2002: Kathryn L Kavanagh; Mario Klimacek; Bernd Nidetzky; David K Wilson
The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis.
Biochemistry 2002;41(28):8785-95.