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Annemieke Kavelaars

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Cora H A Nijboer; Jitske Zijlstra; Hilde J C Bonestroo; Annemieke Kavelaars; Cobi J Heijnen
Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage.
Cora H A Nijboer; Hanneke L D M Willemen; Vincent Degos; Pierre Gressens; Cobi J Heijnen; Annemieke Kavelaars
Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage.
Cindy T J van Velthoven; Zinaida S Vexler; Hanneke L D M Willemen; nikita derugin; Cobi J Heijnen; Annemieke Kavelaars; Mirjam Maas; R Ann Sheldon; Donna M Ferriero
Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke.

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2013: Cora H A Nijboer; Jitske Zijlstra; Hilde J C Bonestroo; Annemieke Kavelaars; Cobi J Heijnen
Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage.
Neurobiology of disease 2013;54():432-44.
2013: Cora H A Nijboer; Hanneke L D M Willemen; Vincent Degos; Pierre Gressens; Cobi J Heijnen; Annemieke Kavelaars
Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage.
Neurobiology of disease 2013;54():206-15.
2013: Cindy T J van Velthoven; Zinaida S Vexler; Hanneke L D M Willemen; nikita derugin; Cobi J Heijnen; Annemieke Kavelaars; Mirjam Maas; R Ann Sheldon; Donna M Ferriero
Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke.
Stroke; a journal of cerebral circulation 2013;44(5):1426-32.
2013: Vanessa Donega; Annemieke Kavelaars; Cora H A Nijboer; Cindy Tj van Velthoven; Cobi J Heijnen
The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013;33(5):625-34.
2013: Mirjam van Zuiden; Elbert Geuze; Annemieke Kavelaars; Miranda Olff; Cobi J Heijnen
Predicting PTSD: Pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions.
Brain, behavior, and immunity 2013;30():12-21.
2013: Maria A Hegeman; Pieter M Cobelens; Marije P Hennus; Nicolaas J G Jansen; Annemieke Kavelaars; Marcus J Schultz; Adrianus J van Vught; Cobi J Heijnen
Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury.
PloS one 2013;8(2):e57374.
2013: Vanessa Donega; Martien J H Kas; Annemieke Kavelaars; Cora H A Nijboer; Frank van Bel; Cindy T J van Velthoven; Cobi J Heijnen
Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement.
PloS one 2013;8(1):e51253.
2013: Jeroen J T Otten; Tom Seijkens; Theo J C van Berkel; Marijke M Westra; Erwin Wijnands; Ilze Bot; Martine Bot; Matthias Busch; Saskia C A de Jager; Cobi J Heijnen; Annemieke Kavelaars; Linda Beckers; Beatriz Bermudez; Erik A L Biessen
Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(1):265-76.
2012: Elbert Geuze; Guillén Fernández; Annemieke Kavelaars; Arthur R Rademaker; Guido A van Wingen; Mirjam van Zuiden; Eric Vermetten; Cobi J Heijnen
Glucocorticoid receptor number predicts increase in amygdala activity after severe stress.
Psychoneuroendocrinology 2012;37(11):1837-44.
2012: Mirjam van Zuiden; Eric Vermetten; Mirjam Maas; Karima Amarouchi; Elbert Geuze; Cobi J Heijnen; Annemieke Kavelaars
Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study.
Psychoneuroendocrinology 2012;37(11):1822-36.
2012: Angela M Kaindl; Annemieke Kavelaars; Tifenn Le Charpentier; Jean-Philippe Loeffler; Alain Lombet; Gauthier Loron; Jean Mantz; Stéphane Peineau; Frédérique Rene; Catherine Verney; Denis Vivien; Carine Ali; Vibol Chhor; Graham L Collingridge; Vincent Degos; Elodie GOUADON; Lina Issa; Julien Josserand; Pierre Gressens
Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.
Annals of neurology 2012;72(4):536-49.
2012: Cindy T J van Velthoven; Jitske Zijlstra; Petra S Huppi; Annemieke Kavelaars; Stéphane Sizonenko; Frank van Bel; Yohan van de Looij; Cobi J Heijnen
Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice.
Annals of neurology 2012;71(6):785-96.
2012: Cindy T J van Velthoven; Annemieke Kavelaars; Cobi J Heijnen
Mesenchymal stem cells as a treatment for neonatal ischemic brain damage.
Pediatric research 2012;71(4 Pt 2):474-81.
2012: Maurits P A van Meer; Max A Viergever; Annemieke Kavelaars; Cora H A Nijboer; Willem M Otte; Kajo van der Marel; Jan Willem Berkelbach van der Sprenkel; Rick M Dijkhuizen
Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(13):4495-507.
2012: Janine A E M van Venrooij; Herman G M Westenberg; Sjoerd B A H A Fluitman; Cobi J Heijnen; René S Kahn; Annemieke Kavelaars; Jeroen G Lijmer; Christine C Gispen-de Wied
Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis.
Schizophrenia bulletin 2012;38(2):272-9.
2012: Mirjam van Zuiden; Eric Vermetten; Hanneke L D M Willemen; Karima Amarouchi; Elbert Geuze; Annemieke Kavelaars; Mirjam Maas; Cobi J Heijnen
Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study.
Biological psychiatry 2012;71(4):309-16.
2012: Mirjam van Zuiden; Eric Vermetten; Karima Amarouchi; Elbert Geuze; Annemieke Kavelaars; Mirjam Maas; Cobi J Heijnen
IL-1β reactivity and the development of severe fatigue after military deployment: a longitudinal study.
Journal of neuroinflammation 2012;9():205.
2012: Charlotte H E Weimar; Jan J Brosens; Johanna M T de Vreeden-Elbertse; Birgit Gellersen; Cobi J Heijnen; Annemieke Kavelaars; Nick S Macklon
Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos.
PloS one 2012;7(7):e41424.
2012: Hanneke L D M Willemen; Jitske Zijlstra; Cobi J Heijnen; Xiao-Jiao Huo; Qi-Liang Mao-Ying; Annemieke Kavelaars
MicroRNA-124 as a novel treatment for persistent hyperalgesia.
Journal of neuroinflammation 2012;9():143.
2012: Niels Eijkelkamp; Cobi J Heijnen; Anibal Garza Carbajal; Robert Dantzer; Keith W Kelley; Michael S Minett; Manfred Schedlowski; Huijing Wang; Hanneke L D M Willemen; John N Wood; Annemieke Kavelaars
G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.
Molecular medicine (Cambridge, Mass.) 2012;18():556-64.
2011: Ingrid H E Korenromp; Jules M M van den Bosch; Pieter Zanen; Jan C Grutters; Annemieke Kavelaars; Cobi J Heijnen
Reduced Th2 cytokine production by sarcoidosis patients in clinical remission with chronic fatigue.
Brain, behavior, and immunity 2011;25(7):1498-502.
2011: Cindy T J van Velthoven; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen
Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain.
Brain, behavior, and immunity 2011;25(7):1342-8.
2011: Cindy T J van Velthoven; Frank van Bel; Cobi J Heijnen; Annemieke Kavelaars
Osteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury.
Stroke; a journal of cerebral circulation 2011;42(8):2294-301.
2011: Cora H Nijboer; Frank van Bel; Michael Arthur van der Kooij; Cindy T J van Velthoven; Jitske Zijlstra; Carsten Culmsee; Henrik Hagberg; Cobi J Heijnen; Annemieke Kavelaars
Targeting the p53 pathway to protect the neonatal ischemic brain.
Annals of neurology 2011;70(2):255-64.
2011: Maike ter Wolbeek; Marijke D J Tersteeg-Kamperman; Lorenz J P van Doornen; Annemieke Kavelaars; Cobi J Heijnen
Fatigue, depressive symptoms, and anxiety from adolescence up to young adulthood: a longitudinal study.
Brain, behavior, and immunity 2011;25(6):1249-55.
2011: Annemieke Kavelaars; Huijing Wang; Hanneke L D M Willemen; Anibal Garza Carbajal; Niels Eijkelkamp; Cobi J Heijnen
Microglial GRK2: a novel regulator of transition from acute to chronic pain.
Brain, behavior, and immunity 2011;25(6):1055-60.
2011: Huijing Wang; Anibal Garza Carbajal; Keith W Kelley; Manfred Schedlowski; Robert Dantzer; Niels Eijkelkamp; Cobi J Heijnen; Annemieke Kavelaars
GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia.
Pain 2011;152(7):1649-58.
2011: Mirjam van Zuiden; Annemieke Kavelaars; Arthur R Rademaker; Eric Vermetten; Cobi J Heijnen; Elbert Geuze
A prospective study on personality and the cortisol awakening response to predict posttraumatic stress symptoms in response to military deployment.
Journal of psychiatric research 2011;45(6):713-9.
2011: Paula M C Mommersteeg; Johan Denollet; Annemieke Kavelaars; Elbert Geuze; Eric Vermetten; Cobi J Heijnen
Type D personality, temperament, and mental health in military personnel awaiting deployment.
International journal of behavioral medicine 2011;18(2):131-8.
2011: Saskia C A de Jager; Beatriz Bermúdez; Ilze Bot; Rory R Koenen; Martine Bot; Annemieke Kavelaars; Vivian de Waard; Cobi J Heijnen; Francisco J G Muriana; Christian Weber; Theo Van berkel; Johan Kuiper; Se-Jin Lee; Rocio Abia; Erik A L Biessen
Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis.
The Journal of experimental medicine 2011;208(2):217-25.
2011: Marius Widerøe; Christian Brekken; Pål Erik Goa; Cobi Heijnen; Annemieke Kavelaars; Tina Bugge Pedersen; Jon S Skranes; Ann-Mari Brubakk
Longitudinal manganese-enhanced magnetic resonance imaging of delayed brain damage after hypoxic-ischemic injury in the neonatal rat.
Neonatology 2011;100(4):363-72.
2011: Mirjam van Zuiden; Elbert Geuze; Hanneke L D M Willemen; Eric Vermetten; Mirjam Maas; Cobi J Heijnen; Annemieke Kavelaars
Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment.
The American journal of psychiatry 2011;168(1):89-96.
2011: Carsten Riether; Annemieke Kavelaars; Timo Wirth; Gustavo Pacheco-López; Raphael Doenlen; Hanneke Willemen; Cobi J Heijnen; Manfred Schedlowski; Harald Engler
Stimulation of β₂-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction.
Brain, behavior, and immunity 2011;25(1):59-66.
2010: Xiyong Fan; Annemieke Kavelaars; Cobi J Heijnen; Floris Groenendaal; Frank van Bel
Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury.
Current neuropharmacology 2010;8(4):324-34.
2010: Cindy T J van Velthoven; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen
Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage.
Pediatric research 2010;68(5):419-22.
2010: CM Boomsma; Annemieke Kavelaars; Marinus Eijkemans; Bart CJM Fauser; Cobi J Heijnen; Nicholas S Macklon
Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo.
Fertility and sterility 2010;94(5):1764-8.
2010: Niels Eijkelkamp; Huijing Wang; Anibal Garza-Carbajal; Hanneke L D M Willemen; Fried J Zwartkruis; John N Wood; Robert Dantzer; Keith W Kelley; Cobi J Heijnen; Annemieke Kavelaars
Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(38):12806-15.
2010: Hanneke L D M Willemen; Niels Eijkelkamp; Huijing Wang; Robert Dantzer; Gerald W Dorn; Keith W Kelley; Cobi J Heijnen; Annemieke Kavelaars
Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.
Pain 2010;150(3):550-60.
2010: Wolfgang Bueter; Norman R Saunders; Carina Mallard; Hans-Christian Bauer; Helen B Stolp; Annemieke Kavelaars; Olaf Dammann
NEUROBID--an EU-funded project to study the developing brain barriers.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2010;28(5):411-2.
2010: Cindy T J van Velthoven; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen
Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(28):9603-11.
2010: CM Boomsma; Annemieke Kavelaars; Nuray Bozkurt; Marinus Eijkemans; Bart CJM Fauser; Cobi J Heijnen; Nicholas S Macklon
Is bacterial vaginosis associated with a pro-inflammatory cytokine profile in endometrial secretions of women undergoing IVF?
Reproductive biomedicine online 2010;21(1):133-41.
2010: Cobi J Heijnen; Annemieke Kavelaars
Neuro-immune, behavioral and molecular aspects of brain damage.
Brain, behavior, and immunity 2010;24(5):705-7.
2010: Cora H Nijboer; Michael Arthur van der Kooij; Frank van Bel; frauke ohl; Cobi J Heijnen; Annemieke Kavelaars
Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury.
Brain, behavior, and immunity 2010;24(5):812-21.
2010: Michael Arthur van der Kooij; frauke ohl; Saskia S Arndt; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen
Mild neonatal hypoxia-ischemia induces long-term motor- and cognitive impairments in mice.
Brain, behavior, and immunity 2010;24(5):850-6.
2010: Michael Arthur van der Kooij; Cora H A Nijboer; frauke ohl; Floris Groenendaal; Cobi J Heijnen; Frank van Bel; Annemieke Kavelaars
NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats.
Neurobiology of disease 2010;38(2):266-72.
2010: Cora H Nijboer; Cobi J Heijnen; Hanneke L D M Willemen; Floris Groenendaal; Gerald W Dorn; Frank van Bel; Annemieke Kavelaars
Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice.
Brain, behavior, and immunity 2010;24(3):420-6.
2010: Cindy T J van Velthoven; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen
Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration.
Brain, behavior, and immunity 2010;24(3):387-93.
2010: Niels Eijkelkamp; Cobi J Heijnen; Hanneke L D M Willemen; Ronald Deumens; Elbert A J Joosten; Wendy Kleibeuker; Ilona J M den Hartog; Cindy T J van Velthoven; Cora H A Nijboer; Mohammed A Nassar; Gerald W Dorn; John N Wood; Annemieke Kavelaars
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(6):2138-49.
2010: Maria A Hegeman; Marije P Hennus; Matijs van Meurs; Pieter M Cobelens; Annemieke Kavelaars; Nicolaas J G Jansen; Marcus J Schultz; Adrianus J van Vught; Grietje Molema; Cobi J Heijnen
Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury.
PloS one 2010;5(12):e15653.
2010: Xin Fu; Samantha M Zunich; Jason O'Connor; Annemieke Kavelaars; Robert Dantzer; Keith W Kelley
Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures.
Journal of neuroinflammation 2010;7():43.
2010: Madhuri Salker; Gijs Teklenburg; Mariam Molokhia; Stuart Lavery; Geoffrey H Trew; Tepchongchit Aojanepong; Helen J Mardon; Amali U Lokugamage; Raj Rai; Christian Landles; Bernard A J Roelen; Siobhan Quenby; Ewart W Kuijk; Annemieke Kavelaars; Cobi J Heijnen; Lesley Regan; Nicholas S Macklon; Jan J Brosens
Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss.
PloS one 2010;5(4):e10287.
2010: Gijs Teklenburg; Madhuri Salker; Mariam Molokhia; Stuart Lavery; Geoffrey H Trew; Tepchongchit Aojanepong; Helen J Mardon; Amali U Lokugamage; Raj Rai; Christian Landles; Bernard A J Roelen; Siobhan Quenby; Ewart W Kuijk; Annemieke Kavelaars; Cobi J Heijnen; Lesley Regan; Jan J Brosens; Nicholas S Macklon
Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation.
PloS one 2010;5(4):e10258.
2009: Mirjam van Zuiden; Elbert Geuze; Mirjam Maas; Eric Vermetten; Cobi J Heijnen; Annemieke Kavelaars
Deployment-related severe fatigue with depressive symptoms is associated with increased glucocorticoid binding to peripheral blood mononuclear cells.
Brain, behavior, and immunity 2009;23(8):1132-9.
2009: Cora H A Nijboer; Cobi J Heijnen; Floris Groenendaal; Frank van Bel; Annemieke Kavelaars
Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia.
Stroke; a journal of cerebral circulation 2009;40(10):3362-8.
2009: Cindy T J van Velthoven; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen
Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes.
Brain research reviews 2009;61(1):1-13.
2009: CM Boomsma; Annemieke Kavelaars; Marinus Eijkemans; Eef G W M Lentjes; Bart CJM Fauser; Cobi J Heijnen; Nicholas S Macklon
Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF.
Human reproduction (Oxford, England) 2009;24(6):1427-35.
2009: Pieter M Cobelens; Bart P Van Putte; Annemieke Kavelaars; Cobi J Heijnen; Jozef Kesecioglu
Inflammatory consequences of lung ischemia-reperfusion injury and low-pressure ventilation.
The Journal of surgical research 2009;153(2):295-301.
2009: Marius Widerøe; Øystein Olsen; Tina Bugge Pedersen; Pål Erik Goa; Annemieke Kavelaars; Cobi Heijnen; Jon S Skranes; Ann-Mari Brubakk; Christian Brekken
Manganese-enhanced magnetic resonance imaging of hypoxic-ischemic brain injury in the neonatal rat.
NeuroImage 2009;45(3):880-90.
2009: Bart P Van Putte; Pieter M Cobelens; Niels van der Kaaij; Burkhard Lachmann; Annemieke Kavelaars; Cobi J Heijnen; Jozef Kesecioglu
Exogenous surfactant attenuation of ischemia-reperfusion injury in the lung through alteration of inflammatory and apoptotic factors.
The Journal of thoracic and cardiovascular surgery 2009;137(4):824-8.
2009: Gustavo Pacheco-López; Carsten Riether; Raphael Doenlen; Harald Engler; Maj-Britt Niemi; Andrea Engler; Annemieke Kavelaars; Cobi J Heijnen; Manfred Schedlowski
Calcineurin inhibition in splenocytes induced by pavlovian conditioning.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(4):1161-7.
2009: Michael Arthur van der Kooij; Floris Groenendaal; Annemieke Kavelaars; Cobi J Heijnen; Frank van Bel
Combination of deferoxamine and erythropoietin: therapy for hypoxia-ischemia-induced brain injury in the neonatal rat?
Neuroscience letters 2009;451(2):109-13.
2009: CM Boomsma; Annemieke Kavelaars; Marinus Eijkemans; K Amarouchi; Gijs Teklenburg; D Gutknecht; B J C M Fauser; Cobi J Heijnen; Nicholas S Macklon
Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity.
Reproductive biomedicine online 2009;18(1):85-94.
2009: Niels Eijkelkamp; Cobi J Heijnen; Sigrid Elsenbruch; Gerald Holtmann; Manfred Schedlowski; Annemieke Kavelaars
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
Brain, behavior, and immunity 2009;23(1):18-26.
2008: Rosa Karemaker; John Karemaker; Annemieke Kavelaars; Marijke Tersteeg-Kamperman; Wim Baerts; Sylvia Veen; Jannie F Samsom; Frank van Bel; Cobi J Heijnen
Effects of neonatal dexamethasone treatment on the cardiovascular stress response of children at school age.
Pediatrics 2008;122(5):978-87.
2008: Michael Arthur van der Kooij; Floris Groenendaal; Annemieke Kavelaars; Cobi J Heijnen; Frank van Bel
Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia.
Brain research reviews 2008;59(1):22-33.
2008: Paula M C Mommersteeg; Eric Vermetten; Annemieke Kavelaars; Elbert Geuze; Cobi J Heijnen
Hostility is related to clusters of T-cell cytokines and chemokines in healthy men.
Psychoneuroendocrinology 2008;33(8):1041-50.
2008: Cora H A Nijboer; Cobi J Heijnen; Floris Groenendaal; Michael J May; Frank van Bel; Annemieke Kavelaars
A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage.
Stroke; a journal of cerebral circulation 2008;39(9):2578-86.
2008: Cora H A Nijboer; Cobi J Heijnen; Floris Groenendaal; Michael J May; Frank van Bel; Annemieke Kavelaars
Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines.
Stroke; a journal of cerebral circulation 2008;39(7):2129-37.
2008: Petronila Penela; Catalina Ribas; Ivette Aymerich; Niels Eijkelkamp; Olga Barreiro; Cobi J Heijnen; Annemieke Kavelaars; Francisco Sánchez-Madrid; Federico Mayor
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration.
The EMBO journal 2008;27(8):1206-18.
2008: Rosa Karemaker; Annemieke Kavelaars; Maike ter Wolbeek; Marijke Tersteeg-Kamperman; Wim Baerts; Sylvia Veen; Jannie F Samsom; Gerard H A Visser; Frank van Bel; Cobi J Heijnen
Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age.
Pediatrics 2008;121(4):e870-8.
2008: Maike ter Wolbeek; Lorenz J P van Doornen; Manfred Schedlowski; Onno Eilard Janssen; Annemieke Kavelaars; Cobi J Heijnen
Glucocorticoid sensitivity of immune cells in severely fatigued adolescent girls: a longitudinal study.
Psychoneuroendocrinology 2008;33(3):375-85.
2008: Cora H A Nijboer; Annemieke Kavelaars; Anne Vroon; Floris Groenendaal; Frank van Bel; Cobi J Heijnen
Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(13):3324-32.
2008: Maike ter Wolbeek; Lorenz J P van Doornen; Annemieke Kavelaars; Cobi J Heijnen
Predictors of persistent and new-onset fatigue in adolescent girls.
Pediatrics 2008;121(3):e449-57.
2008: Wendy Kleibeuker; Maria Jurado-Pueyo; Cristina Murga; Niels Eijkelkamp; Federico Mayor; Cobi J Heijnen; Annemieke Kavelaars
Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium.
Journal of neurochemistry 2008;104(4):979-92.
2008: Wendy Kleibeuker; Eran Gabay; Annemieke Kavelaars; Jitske Zijlstra; Gilly Wolf; Nadav Ziv; Raz Yirmiya; Yehuda Shavit; MICHAEL TAL; Cobi J Heijnen
IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2.
Brain, behavior, and immunity 2008;22(2):200-8.
2008: Paula M C Mommersteeg; Cobi J Heijnen; Annemieke Kavelaars; Lorenz J P van Doornen
The HPA-axis and immune function in burnout.
Progress in brain research 2008;167():281-5.
2007: Jan H Houtveen; Annemieke Kavelaars; Cobi J Heijnen; Lorenz J P van Doornen
Heterogeneous medically unexplained symptoms and immune function.
Brain, behavior, and immunity 2007;21(8):1075-82.
2007: Maike ter Wolbeek; Lorenz J P van Doornen; Annemieke Kavelaars; Elise M van de Putte; Manfred Schedlowski; Cobi J Heijnen
Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents.
Brain, behavior, and immunity 2007;21(8):1063-74.
2007: Niels Eijkelkamp; Annemieke Kavelaars; Sigrid Elsenbruch; Manfred Schedlowski; Gerald Holtmann; Cobi J Heijnen
Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(4):G749-57.
2007: Jost Langhorst; Pieter M Cobelens; Annemieke Kavelaars; Cobi J Heijnen; Sven Benson; Nadja Rifaie; Gustav J Dobos; Manfred Schedlowski; Sigrid Elsenbruch
Stress-related peripheral neuroendocrine-immune interactions in women with ulcerative colitis.
Psychoneuroendocrinology 2007;32(8-10):1086-96.
2007: Maria Stella Lombardi; Anne Vroon; Peter Sodaar; Freek Van Muiswinkel; Cobi J Heijnen; Annemieke Kavelaars
Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway.
Journal of neurochemistry 2007;102(3):731-40.
2007: Niels Eijkelkamp; Cobi J Heijnen; Ayscha Lucas; Richard T Premont; Sigrid Elsenbruch; Manfred Schedlowski; Annemieke Kavelaars
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.
Gut 2007;56(6):847-54.
2007: Anne Vroon; Maria Stella Lombardi; Annemieke Kavelaars; Cobi J Heijnen
Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice.
European journal of pharmacology 2007;560(1):9-16.
2007: Wendy Kleibeuker; Annemarie Ledeboer; Niels Eijkelkamp; Linda R Watkins; Steven F Maier; Jitske Zijlstra; Cobi J Heijnen; Annemieke Kavelaars
A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
The European journal of neuroscience 2007;25(6):1696-704.
2007: Maike ter Wolbeek; Lorenz J P van Doornen; Luc E Coffeng; Annemieke Kavelaars; Cobi J Heijnen
Cortisol and severe fatigue: a longitudinal study in adolescent girls.
Psychoneuroendocrinology 2007;32(2):171-82.
2007: Pieter M Cobelens; Annemieke Kavelaars; Cobi J Heijnen; Catalina Ribas; Federico Mayor; Petronila Penela
Hydrogen peroxide impairs GRK2 translation via a calpain-dependent and cdk1-mediated pathway.
Cellular signalling 2007;19(2):269-77.
2007: Cora H A Nijboer; Floris Groenendaal; Annemieke Kavelaars; Henrik Hagberg; Frank van Bel; Cobi J Heijnen
Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(2):282-92.
2007: Cora H A Nijboer; Annemieke Kavelaars; Frank van Bel; Cobi J Heijnen; Floris Groenendaal
Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.
Developmental neuroscience 2007;29(4-5):385-92.
2007: Patrick J G H Kamphuis; Willem de Vries; Joost M Bakker; Annemieke Kavelaars; Jaap E van Dijk; M E I Schipper; Matthijs F M van Oosterhout; Gerda Croiset; Cobi J Heijnen; Frank van Bel; Victor M Wiegant
Reduced life expectancy in rats after neonatal dexamethasone treatment.
Pediatric research 2007;61(1):72-6.
2007: Ayscha Lucas; Pieter M Cobelens; Annemieke Kavelaars; Cobi J Heijnen; Gerald Holtmann; Sebastian Haag; Guido Gerken; Jost Langhorst; Gustav J Dobos; Manfred Schedlowski; Sigrid Elsenbruch
Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission.
Journal of neuroimmunology 2007;182(1-2):195-203.
2006: Rosa Karemaker; Cobi J Heijnen; Sylvia Veen; Wim Baerts; Janny Samsom; Gerard H A Visser; Annemieke Kavelaars; Lorenz J P van Doornen; Frank van Bel
Differences in behavioral outcome and motor development at school age after neonatal treatment for chronic lung disease with dexamethasone versus hydrocortisone.
Pediatric research 2006;60(6):745-50.
2006: Anne Vroon; Cobi J Heijnen; Annemieke Kavelaars
GRKs and arrestins: regulators of migration and inflammation.
Journal of leukocyte biology 2006;80(6):1214-21.
2006: Adriana del Rey; Vijay Renigunta; Alexander H Dalpke; Jens Leipziger; Joana E Matos; Bernard Robaye; Marylou Zuzarte; Annemieke Kavelaars; Peter J Hanley
Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages.
The Journal of biological chemistry 2006;281(46):35147-55.
2006: Paula M C Mommersteeg; Cobi J Heijnen; Annemieke Kavelaars; Lorenz J P van Doornen
Immune and endocrine function in burnout syndrome.
Psychosomatic medicine 2006;68(6):879-86.
2006: Sigrid Elsenbruch; Ayscha Lucas; Gerald Holtmann; Sebastian Haag; Guido Gerken; Natalie Riemenschneider; Jost Langhorst; Annemieke Kavelaars; Cobi J Heijnen; Manfred Schedlowski
Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome.
The American journal of gastroenterology 2006;101(10):2300-7.
2006: Annemieke Kavelaars; Cobi J Heijnen
Stress, genetics, and immunity.
Brain, behavior, and immunity 2006;20(4):313-6.
2006: Tannette G Krediet; Annemieke Kavelaars; Hendrik J Vreman; Cobi J Heijnen; Frank van Bel
Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants.
The Journal of pediatrics 2006;148(6):740-6.
2006: Maike ter Wolbeek; Lorenz J P van Doornen; Annemieke Kavelaars; Cobi J Heijnen
Severe fatigue in adolescents: a common phenomenon?
Pediatrics 2006;117(6):e1078-86.
2006: Damiaan Denys; Sjoerd Fluitman; Annemieke Kavelaars; Cobi J Heijnen; Herman G M Westenberg
Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder.
Psychoneuroendocrinology 2006;31(3):355-60.
2006: Evelyn van den Tweel; Annemieke Kavelaars; Maria Stella Lombardi; Cora H A Nijboer; Floris Groenendaal; Frank van Bel; Cobi J Heijnen
Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage.
Pediatric research 2006;59(3):434-9.
2006: Evelyn van den Tweel; Annemieke Kavelaars; Maria Stella Lombardi; Floris Groenendaal; Michael May; Cobi J Heijnen; Frank van Bel
Selective inhibition of nuclear factor-kappaB activation after hypoxia/ischemia in neonatal rats is not neuroprotective.
Pediatric research 2006;59(2):232-6.
2006: Ayscha Lucas; Gerald Holtmann; Guido Gerken; A Pietsch; U Braun-Lang; K Gilani; K Strassburger; S Gesing; Onno Eilard Janssen; Annemieke Kavelaars; Cobi J Heijnen; Manfred Schedlowski; Sigrid Elsenbruch
Visceral pain and public speaking stress: neuroendocrine and immune cell responses in healthy subjects.
Brain, behavior, and immunity 2006;20(1):49-56.
2006: M Carmen Jiménez-Sainz; Cristina Murga; Annemieke Kavelaars; María Jurado-Pueyo; Beate F Krakstad; Cobi J Heijnen; Federico Mayor; Anna M Aragay
G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits.
Molecular biology of the cell 2006;17(1):25-31.
2005: Evelyn van den Tweel; Cora H A Nijboer; Annemieke Kavelaars; Cobi J Heijnen; Floris Groenendaal; Frank van Bel
Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain.
Journal of neuroimmunology 2005;167(1-2):64-71.
2005: Ronit Avitsur; Annemieke Kavelaars; Cobi J Heijnen; john sheridan
Social stress and the regulation of tumor necrosis factor-alpha secretion.
Brain, behavior, and immunity 2005;19(4):311-7.
2005: Anne Vroon; Annemieke Kavelaars; Volker Limmroth; Maria Stella Lombardi; Marion U Goebel; Anne-Marie Van Dam; Marc G Caron; Manfred Schedlowski; Cobi J Heijnen
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4400-6.
2005: Annemieke Kavelaars; Pieter M Cobelens; Marc A T Teunis; Cobi J Heijnen
Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene.
Journal of neuroimmunology 2005;161(1-2):162-8.
2005: John Dulos; Monique A J van der Vleuten; Annemieke Kavelaars; Cobi J Heijnen; Mieke Boots
CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
Arthritis and rheumatism 2005;52(3):770-8.
2005: John Dulos; Allard Kaptein; Annemieke Kavelaars; Cobi J Heijnen; Mieke Boots
Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b.
Arthritis research & therapy 2005;7(6):R1271-80.
2005: Evelyn van den Tweel; Frank van Bel; Annemieke Kavelaars; Cacha Peeters-Scholte; Johan Haumann; Cora H A Nijboer; Cobi J Heijnen; Floris Groenendaal
Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(1):67-74.
2004: Enikö Sajti; Nico L U Van Meeteren; Annemieke Kavelaars; Janjaap van Der Net; Willem Hendrik Gispen; Cobi J Heijnen
Individual differences in behavior of inbred Lewis rats are associated with severity of joint destruction in adjuvant-induced arthritis.
Brain, behavior, and immunity 2004;18(6):505-14.
2004: Enikö Sajti; Annemieke Kavelaars; Nico L U Van Meeteren; Marc A T Teunis; Willem Hendrik Gispen; Cobi J Heijnen
Tumor angiogenesis and metastasis formation are associated with individual differences in behavior of inbred Lewis rats.
Brain, behavior, and immunity 2004;18(6):497-504.
2004: Marc A T Teunis; Cobi J Heijnen; Alexander R Cools; Annemieke Kavelaars
Reduced splenic natural killer cell activity in rats with a hyperreactive dopaminergic system.
Psychoneuroendocrinology 2004;29(8):1058-64.
2004: Damiaan Denys; Sjoerd Fluitman; Annemieke Kavelaars; Cobi J Heijnen; Herman G M Westenberg
Decreased TNF-alpha and NK activity in obsessive-compulsive disorder.
Psychoneuroendocrinology 2004;29(7):945-52.
2004: Niels Eijkelkamp; Pieter M Cobelens; Virginia M Sanders; Cobi J Heijnen; Annemieke Kavelaars
Tissue specific effects of the beta 2-adrenergic agonist salbutamol on LPS-induced IFN-gamma, IL-10 and TGF-beta responses in vivo.
Journal of neuroimmunology 2004;150(1-2):3-9.
2004: Anne Vroon; Cobi J Heijnen; Maria Stella Lombardi; Pieter M Cobelens; Federico Mayor; Marc G Caron; Annemieke Kavelaars
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4.
Journal of leukocyte biology 2004;75(5):901-9.
2004: Maria Stella Lombardi; Evelyn van den Tweel; Annemieke Kavelaars; Floris Groenendaal; Frank van Bel; Cobi J Heijnen
Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain.
Stroke; a journal of cerebral circulation 2004;35(4):981-6.
2004: Anne Vroon; Cobi J Heijnen; Roel Raatgever; Ivo P Touw; Rob E Ploemacher; Richard T Premont; Annemieke Kavelaars
GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo.
Journal of leukocyte biology 2004;75(4):698-704.
2004: Katharina Haerter; Anne Vroon; Annemieke Kavelaars; Cobi J Heijnen; Volker Limmroth; Enrique Espinosa; Manfred Schedlowski; Sigrid Elsenbruch
In vitro adrenergic modulation of cellular immune functions in experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2004;146(1-2):126-32.
2003: Annemieke Kavelaars; Anne Vroon; Roel P Raatgever; Alan M Fong; Richard T Premont; Dhavalkumar D Patel; Robert J Lefkowitz; Cobi J Heijnen
Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6128-34.
2003: Mirjam B Smeets; Jolanda Fontijn; Annemieke Kavelaars; Gerard Pasterkamp; Dominique P V de Kleijn
The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues.
International journal of experimental pathology 2003;84(2):69-74.
2003: Anne Vroon; Maria Stella Lombardi; Annemieke Kavelaars; Cobi J Heijnen
Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis.
Journal of neuroimmunology 2003;137(1-2):79-86.
2002: Annemieke Kavelaars
Regulated expression of alpha-1 adrenergic receptors in the immune system.
Brain, behavior, and immunity 2002;16(6):799-807.
2002: Damiaan Denys; Annemieke Kavelaars; Cobi J Heijnen; Herman G M Westenberg
A case of venlafaxine-induced inhibition of T-lymphocyte proliferation.
Psychopharmacology 2002;164(4):432.
2002: Marc A T Teunis; Cobi J Heijnen; Frans Sluyter; Joost M Bakker; Anne-Marie Van Dam; Maleen Hof; Alexander R Cools; Annemieke Kavelaars
Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age.
Journal of neuroimmunology 2002;133(1-2):30-8.
2002: Pieter M Cobelens; Annemieke Kavelaars; Anne Vroon; Marion Ringeling; Ruurd van der Zee; Willem van Eden; Cobi J Heijnen
The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5028-35.
2002: Willem van Eden; Ruurd van der Zee; Peter van Kooten; Suzanne E Berlo; Pieter M Cobelens; Annemieke Kavelaars; Cobi J Heijnen; Berent J Prakken; Sarah Roord; Salvatore Albani
Balancing the immune system: Th1 and Th2.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii25-8.
2002: Marc A T Teunis; Annemieke Kavelaars; Emile E Voest; Joost M Bakker; Bart Ellenbroek; Alexander R Cools; Cobi J Heijnen
Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1465-7.
2002: Louis Bont; Jorien Versteegh; Wendy T N Swelsen; Cobi J Heijnen; Annemieke Kavelaars; Frank Brus; Jos M Th Draaisma; Martha Pekelharing-Berghuis; Ronnie A A M van Diemen-Steenvoorde; Jan L L Kimpen
Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity.
Pediatric research 2002;52(3):363-7.
2002: Maria Stella Lombardi; Annemieke Kavelaars; Petronila Penela; Elisabeth J Scholtens; Marta Roccio; Reinhold E Schmidt; Manfred Schedlowski; Federico Mayor; Cobi J Heijnen
Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism.
Molecular pharmacology 2002;62(2):379-88.
2002: Pieter M Cobelens; Annemieke Kavelaars; Ruurd van der Zee; Willem van Eden; Cobi J Heijnen
Dynamics of mycobacterial HSP65-induced T-cell cytokine expression during oral tolerance induction in adjuvant arthritis.
Rheumatology (Oxford, England) 2002;41(7):775-9.
2002: Cobi J Heijnen; Charlotte Rouppe van der Voort; Marion van de Pol; Annemieke Kavelaars
Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells.
Journal of neuroimmunology 2002;125(1-2):66-72.
2002: Maria Stella Lombardi; Annemieke Kavelaars; Cobi J Heijnen
Role and modulation of G protein-coupled receptor signaling in inflammatory processes.
Critical reviews in immunology 2002;22(2):141-63.
2001: Gieta van der Pompe; N Bernards; Annemieke Kavelaars; Cobi J Heijnen
An exploratory study into the effect of exhausting bicycle exercise on endocrine and immune responses in post-menopausal women: relationships between vigour and plasma cortisol concentrations and lymphocyte proliferation following exercise.
International journal of sports medicine 2001;22(6):447-53.
2001: Louis Bont; Cobi J Heijnen; Annemieke Kavelaars; W M C van Aalderen; Frank Brus; Jos M Th Draaisma; Martha Pekelharing-Berghuis; Ronnie A A M van Diemen-Steenvoorde; Jan L L Kimpen
Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity.
The Journal of infectious diseases 2001;184(3):355-8.
2001: Maria Stella Lombardi; Annemieke Kavelaars; Pieter M Cobelens; Reinhold E Schmidt; Manfred Schedlowski; Cobi J Heijnen
Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1635-40.
2001: Joost M Bakker; Annemieke Kavelaars; Patrick J G H Kamphuis; J Zijlstra; Frank van Bel; Cobi J Heijnen
Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor vbeta repertoire in rats.
Journal of neuroimmunology 2001;112(1-2):47-54.
2000: Pieter M Cobelens; Cobi J Heijnen; E E Nieuwenhuis; P P Kramer; Ruurd van der Zee; Willem van Eden; Annemieke Kavelaars
Treatment of adjuvant-induced arthritis by oral administration of mycobacterial Hsp65 during disease.
Arthritis and rheumatism 2000;43(12):2694-702.
2000: Joost M Bakker; Annemieke Kavelaars; Patrick J G H Kamphuis; Pieter M Cobelens; H H van Vugt; F van Bel; Cobi J Heijnen
Neonatal dexamethasone treatment increases susceptibility to experimental autoimmune disease in adult rats.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5932-7.
2000: E E Nieuwenhuis; M R Visser; Annemieke Kavelaars; Pieter M Cobelens; A Fleer; W Harmsen; Jan Verhoef; L M Akkermans; Cobi J Heijnen
Oral antibiotics as a novel therapy for arthritis: evidence for a beneficial effect of intestinal Escherichia coli.
Arthritis and rheumatism 2000;43(11):2583-9.
2000: C Roupe van der Voort; Cobi J Heijnen; Nico M Wulffraat; Wietse Kuis; Annemieke Kavelaars
Stress induces increases in IL-6 production by leucocytes of patients with the chronic inflammatory disease juvenile rheumatoid arthritis: a putative role for alpha(1)-adrenergic receptors.
Journal of neuroimmunology 2000;110(1-2):223-9.
2000: LM Knook; Annemieke Kavelaars; Gerben Sinnema; Wietse Kuis; Cobi J Heijnen
High nocturnal melatonin in adolescents with chronic fatigue syndrome.
The Journal of clinical endocrinology and metabolism 2000;85(10):3690-2.
2000: Charlotte Rouppe van der Voort; Annemieke Kavelaars; Marion van de Pol; Cobi J Heijnen
Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors.
Journal of neuroimmunology 2000;108(1-2):82-91.
2000: Louis Bont; Annemieke Kavelaars; Cobi J Heijnen; A J van Vught; Jan L L Kimpen
Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis.
The Journal of infectious diseases 2000;181(5):1772-5.
2000: Louis Bont; Cobi J Heijnen; Annemieke Kavelaars; W M C van Aalderen; Frank Brus; JT Draaisma; S M Geelen; Jan L L Kimpen
Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study.
American journal of respiratory and critical care medicine 2000;161(5):1518-23.
2000: Annemieke Kavelaars; Wietse Kuis; LM Knook; Gerben Sinnema; Cobi J Heijnen
Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome.
The Journal of clinical endocrinology and metabolism 2000;85(2):692-6.
2000: Annemieke Kavelaars; Cobi J Heijnen
Expression of preproenkephalin mRNA and production and secretion of enkephalins by human thymocytes.
Annals of the New York Academy of Sciences 2000;917():778-83.
1999: Cobi J Heijnen; Annemieke Kavelaars
The importance of being receptive.
Journal of neuroimmunology 1999;100(1-2):197-202.
1999: Cornelius R Pawlak; Roland Jacobs; E Mikeska; S Ochsmann; Maria Stella Lombardi; Annemieke Kavelaars; Cobi J Heijnen; Reinhold E Schmidt; Manfred Schedlowski
Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress.
Brain, behavior, and immunity 1999;13(4):287-302.
1999: Annemieke Kavelaars; Cobi J Heijnen; R Tennekes; J E Bruggink; J M Koolhaas
Individual behavioral characteristics of wild-type rats predict susceptibility to experimental autoimmune encephalomyelitis.
Brain, behavior, and immunity 1999;13(4):279-86.
1999: Louis Bont; Cobi J Heijnen; Annemieke Kavelaars; W M C van Aalderen; Frank Brus; JT Draaisma; S M Geelen; H J van Vught; Jan L L Kimpen
Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(1):144-9.
1999: Maria Stella Lombardi; Annemieke Kavelaars; Manfred Schedlowski; J W Bijlsma; K L Okihara; Marion van de Pol; S Ochsmann; Cornelius R Pawlak; Reinhold E Schmidt; Cobi J Heijnen
Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(6):715-25.
1999: Charlotte Rouppe van der Voort; Annemieke Kavelaars; Marion van de Pol; Cobi J Heijnen
Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes.
Journal of neuroimmunology 1999;95(1-2):165-73.
1999: Annemieke Kavelaars; Gieta van der Pompe; J M Bakker; P M van Hasselt; B Cats; G H Visser; Cobi J Heijnen
Altered immune function in human newborns after prenatal administration of betamethasone: enhanced natural killer cell activity and decreased T cell proliferation in cord blood.
Pediatric research 1999;45(3):306-12.
1998: Wietse Kuis; Cobi J Heijnen; Gerben Sinnema; Annemieke Kavelaars; Janjaap van Der Net; Paul J M Helders
Pain in childhood rheumatic arthritis.
Baillière's clinical rheumatology 1998;12(2):229-44.
1998: Annemieke Kavelaars; T de Jong-de Vos van Steenwijk; Wietse Kuis; Cobi J Heijnen
The reactivity of the cardiovascular system and immunomodulation by catecholamines in juvenile chronic arthritis.
Annals of the New York Academy of Sciences 1998;840():698-704.
1998: Sylvia Kamphuis; F Eriksson; Annemieke Kavelaars; J Zijlstra; Marion van de Pol; Wietse Kuis; Cobi J Heijnen
Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production.
Journal of neuroimmunology 1998;84(1):53-60.
1998: Joost M Bakker; G P van den Dobbelsteen; H Kroes; Annemieke Kavelaars; Cobi J Heijnen; Fred J H Tilders; EP van Rees
Long-term gender-specific effects of manipulation during pregnancy on immune and endocrine responsiveness in rat offspring.
Journal of neuroimmunology 1998;82(1):56-63.
1997: Sylvia Kamphuis; Annemieke Kavelaars; RA Brooimans; Wietse Kuis; BJ Zegers; Cobi J Heijnen
T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells.
Journal of neuroimmunology 1997;79(1):91-9.
1997: Annemieke Kavelaars; Marion van de Pol; J Zijlstra; Cobi J Heijnen
Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes.
Journal of neuroimmunology 1997;77(2):211-6.
1997: A Berent J Prakken; M J van Hoeij; Wietse Kuis; Annemieke Kavelaars; C J Heynen; Elisabeth J Scholtens; Isme De Kleer; Ger T Rijkers; Willem van Eden
T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint.
Immunology letters 1997;57(1-3):139-42.
1997: Joost M Bakker; Eugene Donné Schmidt; H Kroes; Annemieke Kavelaars; Cobi J Heijnen; Fred J H Tilders; EP van Rees
Effects of neonatal dexamethasone treatment on hypothalamo-pituitary adrenal axis and immune system of the rat.
Journal of neuroimmunology 1997;74(1-2):69-76.
1997: Annemieke Kavelaars; Cobi J Heijnen; B Ellenbroek; H van Loveren; Alexander R Cools
Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their susceptibility to inflammatory and infectious diseases: a study on rats with group-specific differences in structure and reactivity of hypothalamic-pituitary-adrenal axis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(7):2580-4.
1996: Wietse Kuis; C de Jong-de Vos van Steenwijk; Gerben Sinnema; Annemieke Kavelaars; Berent J Prakken; Paul J M Helders; Cobi J Heijnen
The autonomic nervous system and the immune system in juvenile rheumatoid arthritis.
Brain, behavior, and immunity 1996;10(4):387-98.
1996: Cobi J Heijnen; C Rouppe van der Voort; Nico M Wulffraat; Janjaap van Der Net; Wietse Kuis; Annemieke Kavelaars
Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis.
Journal of neuroimmunology 1996;71(1-2):223-6.
1996: Annemieke Kavelaars; B Cats; G H Visser; BJ Zegers; Joost M Bakker; EP van Rees; C J Heunen
Ontogency of the responses of human peripheral blood T cells to glucocorticoids.
Brain, behavior, and immunity 1996;10(3):288-97.
1995: Joost M Bakker; Eugene Donné Schmidt; H Kroes; Annemieke Kavelaars; Cobi J Heijnen; Fred J H Tilders; EP van Rees
Effects of short-term dexamethasone treatment during pregnancy on the development of the immune system and the hypothalamo-pituitary adrenal axis in the rat.
Journal of neuroimmunology 1995;63(2):183-91.
1995: Annemieke Kavelaars; J Zijlstra; Joost M Bakker; EP van Rees; G H Visser; BJ Zegers; Cobi J Heijnen
Increased dexamethasone sensitivity of neonatal leukocytes: different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells.
European journal of immunology 1995;25(5):1346-51.
1994: Annemieke Kavelaars; D Broeke; F Jeurissen; J Kardux; A Meijer; R Franklin; E W Gelfand; Cobi J Heijnen
Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3691-9.
1994: Annemieke Kavelaars; F Jeurissen; Cobi J Heijnen
Substance P receptors and signal transduction in leukocytes.
ImmunoMethods 1994;5(1):41-8.
1994: F Jeurissen; Annemieke Kavelaars; M Korstjens; D Broeke; R A Franklin; E W Gelfand; Cobi J Heijnen
Monocytes express a non-neurokinin substance P receptor that is functionally coupled to MAP kinase.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2987-94.
1993: Annemieke Kavelaars; F Jeurissen; J von Frijtag Drabbe Künzel; J Herman van Roijen; G T Rijkers; Cobi J Heijnen
Substance P induces a rise in intracellular calcium concentration in human T lymphocytes in vitro: evidence of a receptor-independent mechanism.
Journal of neuroimmunology 1993;42(1):61-70.
1992: Annemieke Kavelaars; A Beetsma; J Von Frijtag Drabbe Künzel; Cobi J Heijnen
Beta-endorphin 1-17 modulates high affinity IL-2 receptor expression on human T cells.
Annals of the New York Academy of Sciences 1992;650():234-8.
1991: Annemieke Kavelaars; Rudy E Ballieux; Cobi J Heijnen
Two different signalling pathways for the induction of immunoreactive beta-endorphin secretion by human peripheral blood mononuclear cells.
Endocrinology 1991;128(2):765-70.
1990: Annemieke Kavelaars; Rudy E Ballieux; Cobi J Heijnen
Differential effects of beta-endorphin on cAMP levels in human peripheral blood mononuclear cells.
Brain, behavior, and immunity 1990;4(3):171-9.
1990: Annemieke Kavelaars; Rudy E Ballieux; Cobi J Heijnen
In vitro beta-adrenergic stimulation of lymphocytes induces the release of immunoreactive beta-endorphin.
Endocrinology 1990;126(6):3028-32.
1990: Annemieke Kavelaars; Bart Eggen; P N De Graan; W H Gispen; Cobi J Heijnen
The phosphorylation of the CD3 gamma chain of T lymphocytes is modulated by beta-endorphin.
European journal of immunology 1990;20(4):943-5.
1990: Annemieke Kavelaars; F Berkenbosch; Gerda Croiset; Rudy E Ballieux; Cobi J Heijnen
Induction of beta-endorphin secretion by lymphocytes after subcutaneous administration of corticotropin-releasing factor.
Endocrinology 1990;126(2):759-64.
1989: Annemieke Kavelaars; Rudy E Ballieux; Cobi J Heijnen
The role of IL-1 in the corticotropin-releasing factor and arginine- vasopressin-induced secretion of immunoreactive beta-endorphin by human peripheral blood mononuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2338-42.
1988: Annemieke Kavelaars; Rudy E Ballieux; Cobi J Heijnen
Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation.
Brain, behavior, and immunity 1988;2(1):57-66.
1987: Cobi J Heijnen; J Zijlstra; Annemieke Kavelaars; Gerda Croiset; Rudy E Ballieux
Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes.
Brain, behavior, and immunity 1987;1(4):284-91.