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Atsufumi Kawabata

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Fumiko Sekiguchi; Maho Tsubota-Matsunami; Rumi Yamanaka; Shigeru Yoshida; Yuka Aoki; Daiki Kanaoka; Maiko Nakagawa; Yuta Nishimoto; Atsufumi Kawabata
AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia.
Fumiko Sekiguchi; M Tsubota-Matsunami; Y Maeda; Y Matsumoto; H Nishikawa; Atsufumi Kawabata
Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase-activated receptors?
Maho Matsunami; Takahiro Miki; Hiroyuki Nishikawa; Kanae Nishiura; Yasumasa Okawa; Tomoka Ozaki; Fumiko Sekiguchi; Toshifumi Tsujiuchi; Yuko Hayashi; Lisa Kubo; Atsufumi Kawabata
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.

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2013: Fumiko Sekiguchi; Maho Tsubota-Matsunami; Rumi Yamanaka; Shigeru Yoshida; Yuka Aoki; Daiki Kanaoka; Maiko Nakagawa; Yuta Nishimoto; Atsufumi Kawabata
AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia.
British journal of pharmacology 2013;168(3):734-45.
2012: Fumiko Sekiguchi; M Tsubota-Matsunami; Y Maeda; Y Matsumoto; H Nishikawa; Atsufumi Kawabata
Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase-activated receptors?
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2012;63(6):571-6.
2012: Maho Matsunami; Takahiro Miki; Hiroyuki Nishikawa; Kanae Nishiura; Yasumasa Okawa; Tomoka Ozaki; Fumiko Sekiguchi; Toshifumi Tsujiuchi; Yuko Hayashi; Lisa Kubo; Atsufumi Kawabata
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
British journal of pharmacology 2012;167(4):917-28.
2012: Kazumasa Okubo; Fumiko Sekiguchi; Yuka Aoki; Yudai Kawaishi; Midori Matsumura; Maho Matsunami; Yasumasa Okawa; Atsufumi Kawabata
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice.
British journal of pharmacology 2012;166(5):1738-43.
2012: Kazumasa Okubo; Hiroharu Shibayama; Maho Matsunami; Hiroki Nakanishi; Atsufumi Kawabata
Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats.
British journal of pharmacology 2012;166(3):1058-68.
2012: Maho Matsunami; T Okui; S Kirishi; Atsufumi Kawabata
Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2012;63(1):61-8.
2012: Maho Tsubota-Matsunami; Yumi Noguchi; Yasumasa Okawa; Fumiko Sekiguchi; Atsufumi Kawabata
Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice.
Journal of pharmacological sciences 2012;119(3):293-6.
2011: Yuko Kurokawa; Sachi Matsuda; Hiroyuki Nishikawa; Yukari Okamoto; Fumiko Sekiguchi; Teruki Sekimoto; Yoshiko Yamasaki; Akinori Akaike; Anna Fukatsu; Nobuyuki Fukushima; Satoko Kubo; Toshiaki Kume; Atsufumi Kawabata
Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide.
Biochemical and biophysical research communications 2011;414(4):727-32.
2011: K Okubo; Fumiko Sekiguchi; T Takahashi; J Yamazaki; Shigeru Yoshida; N Fukushima; D Kanaoka; Maho Matsunami; T Ohkubo; Atsufumi Kawabata
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.
Neuroscience 2011;188():148-56.
2011: Takahiro Miki; Maho Matsunami; Saori Nakamura; Hiroki Okada; Hidekazu Matsuya; Atsufumi Kawabata
ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis.
Pain 2011;152(6):1373-81.
2011: Maho Matsunami; S Kirishi; T Okui; Atsufumi Kawabata
Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels.
Neuroscience 2011;181():257-64.
2011: Fumiko Sekiguchi; Ai Ohi; Yuma Maeda; Kaori Takaoka; Teruki Sekimoto; Hiroyuki Nishikawa; Atsufumi Kawabata
Delayed production of arachidonic acid contributes to the delay of proteinase-activated receptor-1 (PAR1)-triggered prostaglandin E2 release in rat gastric epithelial RGM1 cells.
Journal of cellular biochemistry 2011;112(3):909-15.
2010: Sachiyo Nishimura; Hiroyasu Ishikura; Maho Matsunami; Yui Shinozaki; Fumiko Sekiguchi; Mitsuhide Naruse; Taisuke Kitamura; Ryukichi Akashi; Kenji Matsumura; Atsufumi Kawabata
The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.
Life sciences 2010;87(19-22):643-50.
2010: Osamu Fukushima; Sachiyo Nishimura; Maho Matsunami; Yuka Aoki; Hiroyuki Nishikawa; Hiroyasu Ishikura; Atsufumi Kawabata
Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms.
Journal of neuroscience research 2010;88(14):3198-205.
2010: Tomoko Takahashi; Yuka Aoki; Kazumasa Okubo; Yumi Maeda; Fumiko Sekiguchi; Kenji Mitani; Hiroyuki Nishikawa; Atsufumi Kawabata
Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.
Pain 2010;150(1):183-91.
2010: Takeshi Tarui; Kazuki Fukami; Keita Nagasawa; Shigeru Yoshida; Fumiko Sekiguchi; Atsufumi Kawabata
Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide.
Journal of neurochemistry 2010;114(2):512-9.
2010: Kaori Takaoka; Fumiko Sekiguchi; Hidenori Shigi; Yuma Maeda; Hiroyuki Nishikawa; Atsufumi Kawabata
Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release.
Toxicology 2010;268(1-2):40-5.
2010: Kazumi Moriyuki; Fumiko Sekiguchi; Kaori Matsubara; Hiroyuki Nishikawa; Atsufumi Kawabata
Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-κB in human lung epithelial cells.
Journal of pharmacological sciences 2010;114(2):225-9.
2009: Kazumi Moriyuki; Fumiko Sekiguchi; Kaori Matsubara; Hiroyuki Nishikawa; Atsufumi Kawabata
Proteinase-activated receptor-2-triggered prostaglandin E(2) release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt / nuclear factor-kappaB pathway in human alveolar epithelial cells.
Journal of pharmacological sciences 2009;111(3):269-75.
2009: Eiichi Taniguchi; Maho Matsunami; Takeshi Kimura; Daiki Yonezawa; Tsuyoshi Ishiki; Fumiko Sekiguchi; Hiroyuki Nishikawa; Yuma Maeda; Hiroyasu Ishikura; Atsufumi Kawabata
Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification?
Toxicology 2009;264(1-2):96-103.
2009: Toru Kanke; Mototsugu Kabeya; Satoko Kubo; S Kondo; K Yasuoka; J Tagashira; H Ishiwata; Masako Saka; T Furuyama; T Nishiyama; T Doi; Yukio Hattori; Atsufumi Kawabata; M R Cunningham; Robin Plevin
Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo.
British journal of pharmacology 2009;158(1):361-71.
2009: S Nishimura; O Fukushima; H Ishikura; T Takahashi; M Matsunami; T Tsujiuchi; Fumiko Sekiguchi; M Naruse; Y Kamanaka; Atsufumi Kawabata
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
Gut 2009;58(6):762-70.
2009: M Matsunami; T Tarui; K Mitani; K Nagasawa; O Fukushima; K Okubo; S Yoshida; M Takemura; Atsufumi Kawabata
Luminal hydrogen sulfide plays a pronociceptive role in mouse colon.
Gut 2009;58(6):751-61.
2009: Yumi Maeda; Yuka Aoki; Fumiko Sekiguchi; Maho Matsunami; Tomoko Takahashi; Hiroyuki Nishikawa; Atsufumi Kawabata
Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.
Pain 2009;142(1-2):127-32.
2009: Keita Nagasawa; Takeshi Tarui; Shigeru Yoshida; Fumiko Sekiguchi; Maho Matsunami; Ai Ohi; Kazuki Fukami; Seiji Ichida; Hiroyuki Nishikawa; Atsufumi Kawabata
Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels.
Journal of neurochemistry 2009;108(3):676-84.
2008: Yusuke Tanaka; Fumiko Sekiguchi; Hao Hong; Atsufumi Kawabata
PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells.
Biochemical and biophysical research communications 2008;377(2):622-6.
2008: Atsufumi Kawabata; M Matsunami; Fumiko Sekiguchi
Gastrointestinal roles for proteinase-activated receptors in health and disease.
British journal of pharmacology 2008;153 Suppl 1():S230-40.
2008: Mami Nagataki; Kazumi Moriyuki; Fumiko Sekiguchi; Atsufumi Kawabata
Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells.
Cell biochemistry and function 2008;26(2):279-82.
2008: Kazumi Moriyuki; Mami Nagataki; Fumiko Sekiguchi; Hiroyuki Nishikawa; Atsufumi Kawabata
Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells.
Regulatory peptides 2008;145(1-3):42-8.
2007: Fumiko Sekiguchi; K Takaoka; Atsufumi Kawabata
Proteinase-activated receptors in the gastrointestinal system: a functional linkage to prostanoids.
Inflammopharmacology 2007;15(6):246-51.
2007: Satoko Kubo; M Kajiwara; Atsufumi Kawabata
Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats.
Inflammopharmacology 2007;15(6):288-92.
2007: Satoko Kubo; Yuko Kurokawa; Ichiko Doe; Takashi Masuko; Fumiko Sekiguchi; Atsufumi Kawabata
Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase.
Toxicology 2007;241(1-2):92-7.
2007: Daiki Yonezawa; Fumiko Sekiguchi; Misato Miyamoto; Eiichi Taniguchi; Masami Honjo; Takashi Masuko; Hiroyuki Nishikawa; Atsufumi Kawabata
A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium.
Toxicology 2007;241(1-2):11-8.
2007: Atsufumi Kawabata; Tsuyoshi Ishiki; Keita Nagasawa; Shigeru Yoshida; Yumi Maeda; Tomoko Takahashi; Fumiko Sekiguchi; Tetsuyuki Wada; Seiji Ichida; Hiroyuki Nishikawa
Hydrogen sulfide as a novel nociceptive messenger.
Pain 2007;132(1-2):74-81.
2007: Satoko Kubo; Ichiko Doe; Yuko Kurokawa; Atsufumi Kawabata
Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle.
Journal of pharmacological sciences 2007;104(4):392-6.
2007: Hiroyasu Ishikura; Sachiyo Nishimura; Maho Matsunami; Toshifumi Tsujiuchi; Tsuyoshi Ishiki; Fumiko Sekiguchi; Mitsuhide Naruse; Toshio Nakatani; Yoshihisa Kamanaka; Atsufumi Kawabata
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents.
Life sciences 2007;80(21):1999-2004.
2007: Satoko Kubo; Ichiko Doe; Yuko Kurokawa; Hiroyuki Nishikawa; Atsufumi Kawabata
Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension.
Toxicology 2007;232(1-2):138-46.
2007: Fumiko Sekiguchi; Shino Saito; Kaori Takaoka; Hitomi Hayashi; Mami Nagataki; Keita Nagasawa; Hiroyuki Nishikawa; Hirofumi Matsui; Atsufumi Kawabata
Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells.
Biochemical pharmacology 2007;73(1):103-14.
2006: Satoko Kubo; Tsuyoshi Ishiki; Ichiko Doe; Fumiko Sekiguchi; Hiroyuki Nishikawa; Kenzo Kawai; Hirofumi Matsui; Atsufumi Kawabata
Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues.
Annals of the New York Academy of Sciences 2006;1091():445-59.
2006: Maho Matsunami; Tomiko Sekiguchi; Atsufumi Kawabata
[Proteinase-activated receptor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2006;128(6):434-6.
2006: Atsufumi Kawabata; Naoyuki Kawao; Yoshimi Hironaka; Tsuyoshi Ishiki; Maho Matsunami; Fumiko Sekiguchi
Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels.
Neuropharmacology 2006;51(2):182-90.
2006: Atsufumi Kawabata; Naoyuki Kawao; Tomoko Kitano; Maho Matsunami; Reiko Satoh; Tsuyoshi Ishiki; Takashi Masuko; Toru Kanke; Naohiro Saito
Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin.
Neuroscience letters 2006;402(1-2):167-72.
2006: Atsufumi Kawabata; Maho Matsunami; Masahiro Tsutsumi; Tsuyoshi Ishiki; Osamu Fukushima; Fumiko Sekiguchi; Naoyuki Kawao; Takeshi Minami; Toru Kanke; Naohiro Saito
Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice.
British journal of pharmacology 2006;148(1):54-60.
2006: Fumiko Sekiguchi; Naomi Hasegawa; Keiko Inoshita; Daiki Yonezawa; Naoki Inoi; Toru Kanke; Naohiro Saito; Atsufumi Kawabata
Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro.
Life sciences 2006;78(9):950-7.
2005: Naoyuki Kawao; Mami Nagataki; Keita Nagasawa; Satoko Kubo; Kelly Cushing; Tetsuyuki Wada; Fumiko Sekiguchi; Seiji Ichida; Morley D Hollenberg; Wallace K MacNaughton; Hiroyuki Nishikawa; Atsufumi Kawabata
Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells.
The Journal of pharmacology and experimental therapeutics 2005;315(2):576-89.
2005: Toru Kanke; Hiroyuki Ishiwata; Mototsugu Kabeya; Masako Saka; Takeshi Doi; Yukio Hattori; Atsufumi Kawabata; Robin Plevin
Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2.
British journal of pharmacology 2005;145(2):255-63.
2005: Atsufumi Kawabata; Yuko Oono; Daiki Yonezawa; Kaori Hiramatsu; Naoki Inoi; Fumiko Sekiguchi; Masami Honjo; Michiko Hirofuchi; Toru Kanke; Hiroyuki Ishiwata
2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice.
British journal of pharmacology 2005;144(2):212-9.
2005: Atsufumi Kawabata; Naoyuki Kawao
Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles.
Journal of pharmacological sciences 2005;97(1):20-4.
2005: Toru Kanke; Toshiaki Takizawa; Mototsugu Kabeya; Atsufumi Kawabata
Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2 as a potential therapeutic target.
Journal of pharmacological sciences 2005;97(1):38-42.
2004: Atsufumi Kawabata; Yumiko Nakaya; Tsuyoshi Ishiki; Satoko Kubo; Ryotaro Kuroda; Fumiko Sekiguchi; Naoyuki Kawao; Hiroyuki Nishikawa; Kenzo Kawai
Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms.
Life sciences 2004;75(22):2689-702.
2004: Atsufumi Kawabata; Satoko Kubo; Tsuyoshi Ishiki; Naoyuki Kawao; Fumiko Sekiguchi; Ryotaro Kuroda; Morley D Hollenberg; Toru Kanke; Naohiro Saito
Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity.
The Journal of pharmacology and experimental therapeutics 2004;311(1):402-10.
2004: Fumiko Sekiguchi; Yoko Mita; Yoshihisa Kamanaka; Naoyuki Kawao; Hidekazu Matsuya; Chiyomi Taga; Atsufumi Kawabata
The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats.
Neuroscience letters 2004;365(2):111-5.
2004: Atsufumi Kawabata; Hideki Itoh; Naoyuki Kawao; Ryotaro Kuroda; Fumiko Sekiguchi; Takashi Masuko; Koichi Iwata; Akiko Ogawa
Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats.
Neuroreport 2004;15(10):1617-21.
2004: Atsufumi Kawabata; Toru Kanke; Daiki Yonezawa; Tsuyoshi Ishiki; Masako Saka; Mototsugu Kabeya; Fumiko Sekiguchi; Satoko Kubo; Ryotaro Kuroda; Masahiro Iwaki; Kousaku Katsura; Robin Plevin
Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1098-107.
2004: Naoyuki Kawao; Hisao Ikeda; Tomoko Kitano; Ryotaro Kuroda; Fumiko Sekiguchi; Kazuo Kataoka; Yoshihisa Kamanaka; Atsufumi Kawabata
Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.
Journal of pharmacological sciences 2004;94(3):277-85.
2004: Atsufumi Kawabata; Satoko Kubo; Yumiko Nakaya; Tsuyoshi Ishiki; Ryotaro Kuroda; Fumiko Sekiguchi; Naoyuki Kawao; Hiroyuki Nishikawa
Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery.
Cardiovascular research 2004;61(4):683-92.
2004: Atsufumi Kawabata; Hiroyuki Nishikawa; Hitomi Saitoh; Yumiko Nakaya; Kaori Hiramatsu; Satoko Kubo; Minoru Nishida; Naoyuki Kawao; Ryotaro Kuroda; Fumiko Sekiguchi; Mitsuhiro Kinoshita; Kazuaki Kakehi; Naoki Arizono; Hisakazu Yamagishi; Kenzo Kawai
A protective role of protease-activated receptor 1 in rat gastric mucosa.
Gastroenterology 2004;126(1):208-19.
2003: Yoshihisa Kamanaka; Atsufumi Kawabata; Hidekazu Matsuya; Chiyomi Taga; Fumiko Sekiguchi; Naoyuki Kawao
Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.
Life sciences 2003;74(6):793-802.
2003: Naoyuki Kawao; Kaori Hiramatsu; Naoki Inoi; Ryotaro Kuroda; Hiroyuki Nishikawa; Fumiko Sekiguchi; Atsufumi Kawabata
The PAR-1-activating peptide facilitates pepsinogen secretion in rats.
Peptides 2003;24(9):1449-51.
2003: Atsufumi Kawabata; Yumiko Nakaya; Ryotaro Kuroda; Mariko Wakisaka; Takashi Masuko; Hiroyuki Nishikawa; Kenzo Kawai
Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats.
British journal of pharmacology 2003;140(2):247-54.
2003: Ryotaro Kuroda; Atsufumi Kawabata
[Pain information pathways from the periphery to the cerebral cortex].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2003;123(7):533-46.
2002: Atsufumi Kawabata; Ryotaro Kuroda
[PAR (protease-activated receptor) as a novel target for development of gastric mucosal cytoprotective drugs].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(1):85P-87P.
2002: Atsufumi Kawabata; Ryotaro Kuroda; Minoru Nishida; Nanae Nagata; Yuriko Sakaguchi; Naoyuki Kawao; Hiroyuki Nishikawa; Naoki Arizono; Kenzo Kawai
Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion.
Life sciences 2002;71(20):2435-46.
2002: Atsufumi Kawabata; Naoyuki Kawao; Hideki Itoh; Chiho Shimada; Kaori Takebe; Ryotaro Kuroda; Takashi Masuko; Kazuo Kataoka; Shinji Ogawa
Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats.
Neuroscience letters 2002;329(3):349-53.
2002: Atsufumi Kawabata
PAR-2: structure, function and relevance to human diseases of the gastric mucosa.
Expert reviews in molecular medicine 2002;4(16):1-17.
2002: Atsufumi Kawabata; Naoyuki Kawao; Ryotaro Kuroda; Atsuko Tanaka; Chiho Shimada
The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats.
Peptides 2002;23(6):1181-3.
2002: Naoyuki Kawao; Chiho Shimada; Hideki Itoh; Ryotaro Kuroda; Atsufumi Kawabata
Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.
Japanese journal of pharmacology 2002;89(2):184-7.
2002: Atsufumi Kawabata; Mitsuhiro Kinoshita; Ryotaro Kuroda; Kazuaki Kakehi
Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.
Clinical and experimental pharmacology & physiology 2002;29(4):360-1.
2002: Atsufumi Kawabata; Naoyuki Kawao; Ryotaro Kuroda; Hideki Itoh; Hiroyuki Nishikawa
Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats.
Neuroreport 2002;13(4):511-4.
2002: Naoyuki Kawao; Yuriko Sakaguchi; Ai Tagome; Ryotaro Kuroda; Shozo Nishida; Kiyohiro Irimajiri; Hiroyuki Nishikawa; Kenzo Kawai; Morley D Hollenberg; Atsufumi Kawabata
Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion.
British journal of pharmacology 2002;135(5):1292-6.
2001: N Morimoto; M Nakano; Mitsuhiro Kinoshita; Atsufumi Kawabata; M Morita; Yasuo Oda; Ryotaro Kuroda; Kazuaki Kakehi
Specific distribution of sialic acids in animal tissues as examined by LC-ESI-MS after derivatization with 1,2-diamino-4,5-methylenedioxybenzene.
Analytical chemistry 2001;73(22):5422-8.
2001: Atsufumi Kawabata; Ryotaro Kuroda; N Morimoto; Naoyuki Kawao; Takashi Masuko; Kazuaki Kakehi; Kazuo Kataoka; M Taneda; Hiroyuki Nishikawa; H Araki
Lipopolysaccharide-induced subsensitivity of protease-activated receptor-2 in the mouse salivary glands in vivo.
Naunyn-Schmiedeberg's archives of pharmacology 2001;364(3):281-4.
2001: Atsufumi Kawabata; Ryotaro Kuroda; N Nagata; Naoyuki Kawao; Takashi Masuko; Hiroyuki Nishikawa; Kenzo Kawai
In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse.
British journal of pharmacology 2001;133(8):1213-8.
2001: Ryotaro Kuroda; Naoyuki Kawao; H Yoshimura; W Umeda; M Takemura; Y Shigenaga; Atsufumi Kawabata
Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat.
Brain research 2001;903(1-2):110-6.
2001: Atsufumi Kawabata; Mitsuhiro Kinoshita; Hiroyuki Nishikawa; Ryotaro Kuroda; Minoru Nishida; H Araki; Naoki Arizono; Yasuo Oda; Kazuaki Kakehi
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.
The Journal of clinical investigation 2001;107(11):1443-50.
2001: Atsufumi Kawabata; Ryotaro Kuroda; Y Nakaya; Kenzo Kawai; Hiroyuki Nishikawa; Naoyuki Kawao
Factor Xa-evoked relaxation in rat aorta: involvement of PAR-2.
Biochemical and biophysical research communications 2001;282(2):432-5.
2001: Atsufumi Kawabata; Naoyuki Kawao; Ryotaro Kuroda; A Tanaka; Hideki Itoh; Hiroyuki Nishikawa
Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats.
Neuroreport 2001;12(4):715-9.
2001: Atsufumi Kawabata
[The G protein-coupled protease receptor PAR (protease-activated receptor) as a novel target for drug development].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2001;121(1):1-7.
2000: Atsufumi Kawabata; Ryotaro Kuroda; N Kuroki; Hiroyuki Nishikawa; Kenzo Kawai; H Araki
Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
Life sciences 2000;67(20):2521-30.
2000: Atsufumi Kawabata; Ryotaro Kuroda; N Kuroki; Hiroyuki Nishikawa; K Kawai
Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1.
British journal of pharmacology 2000;131(3):578-84.
2000: Mitsuhiro Kinoshita; K Inagake; Atsufumi Kawabata; Ryotaro Kuroda; Yasuo Oda; Kazuaki Kakehi
Fluorometric determination of mucin-type glycoproteins by the galactose oxidase-peroxidase method.
Analytical biochemistry 2000;284(1):87-92.
2000: Atsufumi Kawabata; N Morimoto; Yasuo Oda; Mitsuhiro Kinoshita; Ryotaro Kuroda; Kazuaki Kakehi
Determination of mucin in salivary glands using sialic acids as the marker by high-performance liquid chromatography with fluorometric detection.
Analytical biochemistry 2000;283(1):119-21.
2000: Ryotaro Kuroda; Atsufumi Kawabata; Naoyuki Kawao; W Umeda; M Takemura; Y Shigenaga
Somatosensory cortex stimulation-evoked analgesia in rats: potentiation by NO synthase inhibition.
Life sciences 2000;66(20):PL271-6.
2000: Atsufumi Kawabata; N Morimoto; Hiroyuki Nishikawa; Ryotaro Kuroda; Yasuo Oda; Kazuaki Kakehi
Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland.
Biochemical and biophysical research communications 2000;270(1):298-302.
2000: Atsufumi Kawabata; Hiroyuki Nishikawa; Ryotaro Kuroda; Kenzo Kawai; M D Hollenberg
Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice.
British journal of pharmacology 2000;129(8):1808-14.
2000: Atsufumi Kawabata; Ryotaro Kuroda
Protease-activated receptor (PAR), a novel family of G protein-coupled seven trans-membrane domain receptors: activation mechanisms and physiological roles.
Japanese journal of pharmacology 2000;82(3):171-4.
1999: Atsufumi Kawabata; Ryotaro Kuroda; M D Hollenberg
[Physiology of protease-activated receptors (PARs): involvement of PARs in digestive functions].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():173P-179P.
1999: Atsufumi Kawabata; Ryotaro Kuroda; Hiroyuki Nishikawa; Kenzo Kawai
Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation.
British journal of pharmacology 1999;128(4):865-72.
1999: Atsufumi Kawabata; Ryotaro Kuroda; Hiroyuki Nishikawa; T Asai; Kazuo Kataoka; M Taneda
Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide.
British journal of pharmacology 1999;126(8):1856-62.
1998: Atsufumi Kawabata; Ryotaro Kuroda; T Minami; K Kataoka; M Taneda
Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw.
British journal of pharmacology 1998;125(3):419-22.
1998: Atsufumi Kawabata; T Hata; Ryotaro Kuroda
Cross tolerance to environmental stress and endotoxin.
Life sciences 1998;62(21):PL 327-33.