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Toshiaki Kawakami

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Jun-Ichi Kashiwakura; masutaka furue; Kenji Kabashima; Yuko Kawakami; Yoshimichi Okayama; Chisei Ra; Shinji Shimada; Reuben P Siraganian; Toshiaki Kawakami
Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.
Toshiaki Kawakami
Human FcγRIIA at center stage.
Toshiaki Kawakami; Wenbin Xiao; Hiroki Yasudo; Yuko Kawakami
Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase.

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All Publications

2012: Jun-Ichi Kashiwakura; masutaka furue; Kenji Kabashima; Yuko Kawakami; Yoshimichi Okayama; Chisei Ra; Shinji Shimada; Reuben P Siraganian; Toshiaki Kawakami
Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.
Allergy, asthma & immunology research 2012;4(6):332-40.
2012: Toshiaki Kawakami
Human FcγRIIA at center stage.
Blood 2012;119(11):2432-3.
2012: Toshiaki Kawakami; Wenbin Xiao; Hiroki Yasudo; Yuko Kawakami
Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase.
Advances in biological regulation 2012;52(1):7-15.
2011: Wenbin Xiao; Hiroki Yasudo; Yuko Kawakami; Mari Maeda-Yamamoto; Dianqing Wu; Tomoaki Ando; Hong Hong; Jun-Ichi Kashiwakura; Toshiaki Kawakami
Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1.
Immunity 2011;34(6):893-904.
2011: Hiroki Yasudo; Tomoaki Ando; Yuko Kawakami; Wenbin Xiao; Toshiaki Kawakami
Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation.
PloS one 2011;6(9):e24995.
2011: Jun-Ichi Kashiwakura; Iris M Otani; Toshiaki Kawakami
Monomeric IgE and mast cell development, survival and function.
Advances in experimental medicine and biology 2011;716():29-46.
2011: Yoshiaki Tomimori; Yuko Kawakami; Megan M McCausland; Tomoaki Ando; Lilia Koriazova; Shinichiro Kato; Toshiaki Kawakami; Shane Crotty
Protective murine and human monoclonal antibodies against eczema vaccinatum.
Antiviral therapy 2011;16(1):67-75.
2010: Wenbin Xiao; Tomoaki Ando; Huan-You Wang; Yuko Kawakami; Toshiaki Kawakami
Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.
Blood 2010;116(26):6003-13.
2010: Michael Poderycki; Yoshiaki Tomimori; Tomoaki Ando; Wenbin Xiao; Mari Maeda-Yamamoto; Karsten Sauer; Yuko Kawakami; Toshiaki Kawakami
A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):84-93.
2009: Toshiaki Kawakami
A crucial door to the mast cell mystery knocked in.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6861-2.
2009: Toshiaki Kawakami; Tomoaki Ando; Miho Kimura; Bridget S Wilson; Yuko Kawakami
Mast cells in atopic dermatitis.
Current opinion in immunology 2009;21(6):666-78.
2009: Jun-ichi Kashiwakura; Yuko Kawakami; Keisuke Yuki; Dirk M Zajonc; Shunji Hasegawa; Yoshiaki Tomimori; Benjamin Caplan; Hirohisa Saito; masutaka furue; Hans C Oettgen; Yoshimichi Okayama; Toshiaki Kawakami
Polyclonal IgE induces mast cell survival and cytokine production.
Allergology international : official journal of the Japanese Society of Allergology 2009;58(3):411-9.
2009: Wenbin Xiao; Hong Hong; Yuko Kawakami; Yuko Kato; Dianqing Wu; Hiroki Yasudo; Akiko Kimura; Hiromi Kubagawa; Luigi F Bertoli; Randall S Davis; Luan A Chau; Joaquin Madrenas; Cyrus C Hsia; Anargyros Xenocostas; Thomas Kipps; Lothar Hennighausen; Atsushi Iwama; Hiromitsu Nakauchi; Toshiaki Kawakami
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Cancer cell 2009;16(2):161-71.
2008: Jun-ichi Kashiwakura; Wenbin Xiao; Jiro Kitaura; Yuko Kawakami; Mari Maeda-Yamamoto; Janet R Pfeiffer; Bridget S Wilson; Ulrich Blank; Toshiaki Kawakami
Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.
Journal of leukocyte biology 2008;84(2):357-67.
2006: Huan-Yuan Chen; Bhavya B Sharma; Lan Yu; Riaz I Zuberi; I-Chun Weng; Yuko Kawakami; Toshiaki Kawakami; Daniel K Hsu; Fu-Tong Liu
Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):4991-7.
2004: Riaz I Zuberi; Daniel K Hsu; Omer Kalayci; Huan-Yuan Chen; Holly K Sheldon; Lan Yu; John R Apgar; Toshiaki Kawakami; Craig M Lilly; Fu-Tong Liu
Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma.
The American journal of pathology 2004;165(6):2045-53.
2002: Toshiaki Kawakami; Yuko Kawakami; Jiro Kitaura
Protein kinase C beta (PKC beta): normal functions and diseases.
Journal of biochemistry 2002;132(5):677-82.
2002: Toshiaki Kawakami; Stephen J Galli
Regulation of mast-cell and basophil function and survival by IgE.
Nature reviews. Immunology 2002;2(10):773-86.
2001: K Asai; Jiro Kitaura; Y Kawakami; N Yamagata; M Tsai; D P Carbone; Fu-Tong Liu; Stephen J Galli; Toshiaki Kawakami
Regulation of mast cell survival by IgE.
Immunity 2001;14(6):791-800.
2000: Jiro Kitaura; K Asai; Mari Maeda-Yamamoto; Y Kawakami; U Kikkawa; Toshiaki Kawakami
Akt-dependent cytokine production in mast cells.
The Journal of experimental medicine 2000;192(5):729-40.
2000: Y Kawakami; Jiro Kitaura; Anne B Satterthwaite; R M Kato; K Asai; SE Hartman; Mari Maeda-Yamamoto; Clifford A Lowell; David J Rawlings; Owen N Witte; Toshiaki Kawakami
Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1210-9.
2000: Y Kawakami; Jiro Kitaura; SE Hartman; Clifford A Lowell; R P Siraganian; Toshiaki Kawakami
Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7423-8.
1999: L Yao; P Janmey; L G Frigeri; W Han; J Fujita; Y Kawakami; John R Apgar; Toshiaki Kawakami
Pleckstrin homology domains interact with filamentous actin.
The Journal of biological chemistry 1999;274(28):19752-61.
1999: Y Kawakami; SE Hartman; E Kinoshita; H Suzuki; Jiro Kitaura; L Yao; N Inagaki; A Franco; D Hata; Mari Maeda-Yamamoto; H Fukamachi; H Nagai; Toshiaki Kawakami
Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2227-32.
1999: Y Kawakami; Jiro Kitaura; D Hata; L Yao; Toshiaki Kawakami
Functions of Bruton's tyrosine kinase in mast and B cells.
Journal of leukocyte biology 1999;65(3):286-90.
1998: Y Kawakami; SE Hartman; P M Holland; J A Cooper; Toshiaki Kawakami
Multiple signaling pathways for the activation of JNK in mast cells: involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1795-802.
1998: J Deng; Y Kawakami; SE Hartman; T Satoh; Toshiaki Kawakami
Involvement of Ras in Bruton's tyrosine kinase-mediated JNK activation.
The Journal of biological chemistry 1998;273(27):16787-91.
1998: D Hata; Jiro Kitaura; SE Hartman; Y Kawakami; T Yokota; Toshiaki Kawakami
Bruton's tyrosine kinase-mediated interleukin-2 gene activation in mast cells. Dependence on the c-Jun N-terminal kinase activation pathway.
The Journal of biological chemistry 1998;273(18):10979-87.
1998: D Hata; Y Kawakami; N Inagaki; C S Lantz; T Kitamura; Wasif Khan; Mari Maeda-Yamamoto; T Miura; W Han; SE Hartman; L Yao; H Nagai; A E Goldfeld; FW Alt; Stephen J Galli; Owen N Witte; Toshiaki Kawakami
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.
The Journal of experimental medicine 1998;187(8):1235-47.
1997: L Yao; H Suzuki; K Ozawa; J Deng; Csaba Lehel; H Fukamachi; Wayne B Anderson; Y Kawakami; Toshiaki Kawakami
Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bisphosphate and phorbol 12-myristate 13-acetate.
The Journal of biological chemistry 1997;272(20):13033-9.
1997: Y Kawakami; T Miura; R Bissonnette; D Hata; Wasif Khan; T Kitamura; Mari Maeda-Yamamoto; SE Hartman; L Yao; FW Alt; Toshiaki Kawakami
Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3938-42.
1992: Toshiaki Kawakami; N Inagaki; M Takei; H Fukamachi; K Mark Coggeshall; KIMISHIGE ISHIZAKA; TERUKO ISHIZAKA
Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3513-9.