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Yutaka Kawakami

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Takahiro Tsujikawa; Tomonori Yaguchi; Akio Yanagisawa; Tomonobu Fujita; Yasuo Hisa; Naoshi Kawamura; Asuka Kobayashi; Hiroshi Nakano; Ryuta Nakao; Gaku Ohmura; Shigeki Ohta; Taketoshi Shimada; Takeshi Takahashi; Yutaka Kawakami
Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.
Yutaka Kawakami; Tomoko Iwata-Kajihara; Hajime Kamijuku; Asuka Kobayashi; Chie Kudo-Saito; Shoko Nakamura; Hiroshi Nishio; Jeong Hoon Park; Ryosuke Satomi; Hidetoshi Sumimoto; Mayuri Tanaka; Takahiro Tsujikawa; Nobuo Tsukamoto; Tomonori Yaguchi; Naoshi Kawamura
Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy.
Chie Kudo-Saito; Misa Ohike; Hiromi Shirako; Nobuo Tsukamoto; Yutaka Kawakami
CCL2 is critical for immunosuppression to promote cancer metastasis.

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2013: Takahiro Tsujikawa; Tomonori Yaguchi; Akio Yanagisawa; Tomonobu Fujita; Yasuo Hisa; Naoshi Kawamura; Asuka Kobayashi; Hiroshi Nakano; Ryuta Nakao; Gaku Ohmura; Shigeki Ohta; Taketoshi Shimada; Takeshi Takahashi; Yutaka Kawakami
Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2013;132(12):2755-66.
2013: Yutaka Kawakami; Tomoko Iwata-Kajihara; Hajime Kamijuku; Asuka Kobayashi; Chie Kudo-Saito; Shoko Nakamura; Hiroshi Nishio; Jeong Hoon Park; Ryosuke Satomi; Hidetoshi Sumimoto; Mayuri Tanaka; Takahiro Tsujikawa; Nobuo Tsukamoto; Tomonori Yaguchi; Naoshi Kawamura
Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy.
Annals of the New York Academy of Sciences 2013;1284(1):80-6.
2013: Chie Kudo-Saito; Misa Ohike; Hiromi Shirako; Nobuo Tsukamoto; Yutaka Kawakami
CCL2 is critical for immunosuppression to promote cancer metastasis.
Clinical & experimental metastasis 2013;30(4):393-405.
2013: Shigeki Ohta; Hideyuki Okano; Wado Akamatsu; Yoichi Imaizumi; Yutaka Kawakami
Generation of human melanocytes from induced pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.) 2013;989():193-215.
2013: Hideko Akagi; Shinsuke Funakoshi; Yasuo Hamamoto; Masayuki Adachi; Hajime Higuchi; Toru Igarashi; Motoko Izumiya; Ayano Kabashima; Takanori Kanai; Yutaka Kawakami; Hiroyuki Mizuguchi; Shoko Nakamura; Gen Sakai; Hidetoshi Sumimoto; Hiromasa Takaishi; Toshifumi Hibi
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2013;16(1):100-10.
2012: Yutaka Kawakami; Maiko Matsushita; Nobuo Tsukamoto; Ryo Ueda; Shigeki Ohta
[Immunotherapy targeting cancer stem cells].
Nihon rinsho. Japanese journal of clinical medicine 2012;70(12):2142-6.
2012: Yutaka Kawakami
[Molecular targets for development of cancer immunotherapy].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():144-8.
2012: Tomonori Yaguchi; Tomonobu Fujita; Yasufumi Goto; Kenji Kido; Chie Kudo-Saito; Hiroshi Mochimaru; Toshiharu Sakurai; Hidetoshi Sumimoto; Nobuo Tsukamoto; Yutaka Kawakami
Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2110-7.
2012: Koji Okabayashi; Tsutomu Okada; Hiroya Takeuchi; Nobuo Tsukamoto; Masakazu Ueda; Tomonobu Fujita; Naoki Goshima; Hirotoshi Hasegawa; Nobumaru Hirao; Takashi Iwata; Yuko Kitagawa; Junichiro Miyazaki; Shinobu Noji; Yutaka Kawakami
Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer.
Cancer science 2012;103(9):1617-24.
2012: Shigeki Ohta; Hideyuki Okano; Raita Fukaya; Satoshi Inoue; Yonehiro Kanemura; Yutaka Kawakami; Aya Misawa; Masahiro Toda
Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells.
Journal of cell science 2012;125(Pt 13):3210-20.
2012: Yutaka Kawakami; Yoshie Kawase; Shinobu Noji; Azusa Ohizumi; Toshiharu Sakurai; Tomonobu Fujita
[Biomarkers for cancer immunotherapy].
Nihon rinsho. Japanese journal of clinical medicine 2012;70(5):759-66.
2012: Takatsune Shimizu; Eiji Sugihara; Yoshiaki Toyama; Arisa Ueki; Tomonori Yaguchi; Hiroshi Ijiri; Yasuo Ikeda; Tomoki Ishikawa; Sayaka Iwai; Yutaka Kawakami; Shinji Kuninaka; Yumi Matsuzaki; Takeshi Miyamoto; Hajime Mori; Hiroshi Nishio; Nobuyuki Onishi; Hideyuki Saya
Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma.
Molecular cancer research : MCR 2012;10(3):454-68.
2012: Satoshi Takahashi; Kazunari Yoshida; Noemi Fusaki; Yukihiko Iizuka; Kohei Inagawa; Yoshihiro Iwahori; Yutaka Kawakami; Shigeki Ohta; Masahiro Toda
Downregulation of KIF23 suppresses glioma proliferation.
Journal of neuro-oncology 2012;106(3):519-29.
2012: Mizuka Kamoi; Yutaka Kawakami; Tetsuya Kawakita; Toshihiro Nagai; Shigeru Nakamura; Hiroto Obata; Yoko Ogawa; Yasunori Okada; Shigeto Shimmura; Murat Dogru; Masataka Ito; Minako Kaido; Kazuo Tsubota
Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjögren's type dry eye in visual display terminal users.
PloS one 2012;7(9):e43688.
2012: Saori Yaguchi; Shin Hatou; Toshihiro Imada; Takaaki Inaba; Susumu Ishida; Yutaka Kawakami; Shigeru Nakamura; Yoko Ogawa; Yoko Ozawa; Shigeto Shimmura; Kazuo Tsubota
Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland.
Investigative ophthalmology & visual science 2012;53(9):5416-25.
2011: Tomoko Iwata-Kajihara; Naoshi Kawamura; Makoto Miyagishi; Hiroyuki Mizuguchi; Hidetoshi Sumimoto; Tomomi Takahashi; Kiyoshi Takeda; Ryo Ueda; Yutaka Kawakami
Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):27-36.
2011: Tomonori Yaguchi; Hidetoshi Sumimoto; Chie Kudo-Saito; Nobuo Tsukamoto; Ryo Ueda; Tomoko Iwata-Kajihara; Hiroshi Nishio; Naoshi Kawamura; Yutaka Kawakami
The mechanisms of cancer immunoescape and development of overcoming strategies.
International journal of hematology 2011;93(3):294-300.
2011: Masanao Tabuse; Cécile Thirant; Kazunari Yoshida; Hérve Chneiweiss; Raita Fukaya; Yutaka Kawakami; Takeshi Kawase; Yumi Matsuzaki; Aya Misawa; Yohei Ohashi; Shigeki Ohta; Hideyuki Okano; Hideyuki Saya; Masahiro Toda
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.
Molecular cancer 2011;10():60.
2011: Shigeki Ohta; Yoichi Imaizumi; Yohei Okada; Wado Akamatsu; Reiko Kuwahara; Manabu Ohyama; Masayuki Amagai; Yumi Matsuzaki; Shinya Yamanaka; Hideyuki Okano; Yutaka Kawakami
Generation of human melanocytes from induced pluripotent stem cells.
PloS one 2011;6(1):e16182.
2011: Kozo Ohkusu-Tsukada; Shigeki Ohta; Yutaka Kawakami; Masahiro Toda
Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy.
International journal of cancer. Journal international du cancer 2011;128(1):119-31.
2010: Yutaka Kawakami
[Cancer treatment by comprehensive regulation of anti-tumor immune network].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(6):1094-9.
2010: Raita Fukaya; Shigeki Ohta; Masayuki Yamaguchi; Hirofumi Fujii; Yutaka Kawakami; Takeshi Kawase; Masahiro Toda
Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line, SK-MG-1.
Cancer letters 2010;291(2):150-7.
2010: Ryo Ueda; Kozo Ohkusu-Tsukada; Noemi Fusaki; Akio Soeda; Takeshi Kawase; Yutaka Kawakami; Masahiro Toda
Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy.
International journal of cancer. Journal international du cancer 2010;126(4):919-29.
2010: Hidetoshi Sumimoto; Yutaka Kawakami
The RNA silencing technology applied by lentiviral vectors in oncology.
Methods in molecular biology (Clifton, N.J.) 2010;614():187-99.
2009: Yoko Ogawa; Shigeto Shimmura; Tetsuya Kawakita; Satoru Yoshida; Yutaka Kawakami; Kazuo Tsubota
Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.
The American journal of pathology 2009;175(6):2372-81.
2009: Kenji Kido; Hidetoshi Sumimoto; Sakiyo Asada; Starlyn M Okada; Tomonori Yaguchi; Naoshi Kawamura; Makoto Miyagishi; Toshiaki Saida; Yutaka Kawakami
Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation.
Cancer science 2009;100(10):1863-9.
2009: Nobuo Tsukamoto; Starlyn Okada; Yoko Onami; Yusuke Sasaki; Kazuo Umezawa; Yutaka Kawakami
Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5733-43.
2009: Hiroshi Mochimaru; Eri Takahashi; Nobuo Tsukamoto; Junichiro Miyazaki; Tomonori Yaguchi; Takashi Koto; Toshihide Kurihara; Kousuke Noda; Yoko Ozawa; Takatsugu Ishimoto; Yutaka Kawakami; Hidenobu Tanihara; Hideyuki Saya; Susumu Ishida; Kazuo Tsubota
Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization.
Investigative ophthalmology & visual science 2009;50(9):4410-5.
2009: Shinji Sato; Kana Hoshino; Takashi Satoh; Tomonobu Fujita; Yutaka Kawakami; Takashi Fujita; Masataka Kuwana
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Arthritis and rheumatism 2009;60(7):2193-200.
2009: Kaori Hayashi; Shigeki Ohta; Yutaka Kawakami; Masahiro Toda
Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF.
Neuroscience research 2009;64(1):96-103.
2009: Toru Satoh; Janardan P Pandey; Yuka Okazaki; Atsuko Asahi; Yutaka Kawakami; Yasuo Ikeda; Masataka Kuwana
Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura.
Tissue antigens 2009;73(4):353-7.
2009: Chie Kudo-Saito; Hiromi Shirako; Tadashi Takeuchi; Yutaka Kawakami
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
Cancer cell 2009;15(3):195-206.
2008: Atsuko Asahi; Tetsuya Nishimoto; Yuka Okazaki; Hidekazu Suzuki; Tatsuhiro Masaoka; Yutaka Kawakami; Yasuo Ikeda; Masataka Kuwana
Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibitory FcgammaRIIB in immune thrombocytopenic purpura patients.
The Journal of clinical investigation 2008;118(8):2939-49.
2008: Masae Yaguchi; Shigeki Ohta; Yoshiaki Toyama; Yutaka Kawakami; Masahiro Toda
Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL-12 administration.
Journal of neuroscience research 2008;86(9):1972-80.
2008: Ryo Ueda; Eiko Kinoshita; Rena Ito; Takeshi Kawase; Yutaka Kawakami; Masahiro Toda
Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6.
International journal of cancer. Journal international du cancer 2008;122(10):2274-9.
2008: Shigeki Ohta; Yoko Ueda; Masae Yaguchi; Yumi Matsuzaki; Masaya Nakamura; Yoshiaki Toyama; Yoshikuni Tanioka; Norikazu Tamaoki; Tatsuji Nomura; Hideyuki Okano; Yutaka Kawakami; Masahiro Toda
Isolation and characterization of dendritic cells from common marmosets for preclinical cell therapy studies.
Immunology 2008;123(4):566-74.
2008: Noriyuki Seta; Michiko Tajima; Shigeto Kobayashi; Yutaka Kawakami; Hiroshi Hashimoto; Masataka Kuwana
Autoreactive T-cell responses to myeloperoxidase in patients with antineutrophil cytoplasmic antibody-associated vasculitis and in healthy individuals.
Modern rheumatology / the Japan Rheumatism Association 2008;18(6):593-600.
2008: Yutaka Kawakami; Tomonobu Fujita; Chie Kudo; Toshiharu Sakurai; Masaru Udagawa; Tomonori Yaguchi; Go Hasegawa; Emiko Hayashi; Yoko Ueda; Tomoko Iwata; Qinfu Wang; Starlyn Okada; Nobuo Tsukamoto; Yuriko Matsuzaki; Hidetoshi Sumimoto
Dendritic cell based personalized immunotherapy based on cancer antigen research.
Frontiers in bioscience : a journal and virtual library 2008;13():1952-8.
2007: Yujiro Hattori; Shigeki Ohta; Kenji Hamada; Hisafumi Yamada-Okabe; Yonehiro Kanemura; Yumi Matsuzaki; Hideyuki Okano; Yutaka Kawakami; Masahiro Toda
Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.
Biochemical and biophysical research communications 2007;364(4):737-42.
2007: Takashi Inozume; Hiroshi Mitsui; Takashi Okamoto; Yuriko Matsuzaki; Yutaka Kawakami; Naotaka Shibagaki; Shinji Shimada
Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma.
The Journal of investigative dermatology 2007;127(12):2818-22.
2007: Emiko Hayashi; Yuriko Matsuzaki; Go Hasegawa; Tomonori Yaguchi; Sachiko Kurihara; Tomonobu Fujita; Toshiro Kageshita; Makoto Sano; Yutaka Kawakami
Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(21):6267-74.
2007: Hiroshi Mochimaru; Norihiro Nagai; Go Hasegawa; Chie Kudo-Saito; Tomonori Yaguchi; Yoshihiko Usui; Toshihide Kurihara; Takashi Koto; Shingo Satofuka; Hajime Shinoda; Yoko Ozawa; Kazuo Tsubota; Yutaka Kawakami; Susumu Ishida
Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2.
Investigative ophthalmology & visual science 2007;48(10):4795-801.
2007: Shigeo Yoshizawa; Katsuyoshi Matsuoka; Nagamu Inoue; Hiromasa Takaishi; Haruhiko Ogata; Yasushi Iwao; Makio Mukai; Tomonobu Fujita; Yutaka Kawakami; Toshifumi Hibi
Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis.
Inflammatory bowel diseases 2007;13(7):865-73.
2007: Ryo Ueda; Kazunari Yoshida; Takeshi Kawase; Yutaka Kawakami; Masahiro Toda
Preferential expression and frequent IgG responses of a tumor antigen, SOX5, in glioma patients.
International journal of cancer. Journal international du cancer 2007;120(8):1704-11.
2007: Yoko Ogawa; Mohammed S Razzaque; Kaori Kameyama; Go Hasegawa; Shigeto Shimmura; Masataka Kawai; Shinichiro Okamoto; Yasuo Ikeda; Kazuo Tsubota; Yutaka Kawakami; Masataka Kuwana
Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD.
Investigative ophthalmology & visual science 2007;48(3):1079-86.
2007: Hayato Takahashi; Masayuki Amagai; Akiko Tanikawa; Shigeaki Suzuki; Yasuo Ikeda; Takeji Nishikawa; Yutaka Kawakami; Masataka Kuwana
T helper type 2-biased natural killer cell phenotype in patients with pemphigus vulgaris.
The Journal of investigative dermatology 2007;127(2):324-30.
2007: Mikio Kajihara; Yuka Okazaki; Shinzo Kato; Hiromasa Ishii; Yutaka Kawakami; Yasuo Ikeda; Masataka Kuwana
Evaluation of platelet kinetics in patients with liver cirrhosis: similarity to idiopathic thrombocytopenic purpura.
Journal of gastroenterology and hepatology 2007;22(1):112-8.
2006: Masaru Udagawa; Chie Kudo-Saito; Go Hasegawa; Kazuhito Yano; Aiko Yamamoto; Masae Yaguchi; Masahiro Toda; Ichiro Azuma; Takehisa Iwai; Yutaka Kawakami
Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin cell wall skeleton stimulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7465-75.
2006: Masataka Kuwana; Yuka Okazaki; Hiroaki Kodama; Takashi Satoh; Yutaka Kawakami; Yasuo Ikeda
Endothelial differentiation potential of human monocyte-derived multipotential cells.
Stem cells (Dayton, Ohio) 2006;24(12):2733-43.
2006: Rie Yamazaki; Masataka Kuwana; Takehiko Mori; Yuka Okazaki; Yutaka Kawakami; Yasuo Ikeda; Shinichiro Okamoto
Prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation: associations with impaired platelet production and increased platelet turnover.
Bone marrow transplantation 2006;38(5):377-84.
2006: Hidetoshi Sumimoto; Fumie Imabayashi; Tomoko Iwata; Yutaka Kawakami
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells.
The Journal of experimental medicine 2006;203(7):1651-6.
2006: Masataka Kuwana; Junichi Kaburaki; Yuka Okazaki; Hidekata Yasuoka; Yutaka Kawakami; Yasuo Ikeda
Increase in circulating endothelial precursors by atorvastatin in patients with systemic sclerosis.
Arthritis and rheumatism 2006;54(6):1946-51.
2006: S Otani; T Sakurai; K Yamamoto; Tomonobu Fujita; Y Matsuzaki; Y Goto; Y Ando; S Suzuki; M Usui; M Takeuchi; Yutaka Kawakami
Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease.
The British journal of ophthalmology 2006;90(6):773-7.
2006: Yasufumi Goto; Yuriko Matsuzaki; Sachiko Kurihara; Ayako Shimizu; Tsutomu Okada; Kazuhiko Yamamoto; Hiroshi Murata; Minoru Takata; Hiroyuki Aburatani; Dave S B Hoon; Toshiaki Saida; Yutaka Kawakami
A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy.
Cancer research 2006;66(8):4443-9.
2006: Hiroaki Kodama; takafumi inoue; Ryuichi Watanabe; Daisuke Yasutomi; Yutaka Kawakami; Satoshi Ogawa; Katsuhiko Mikoshiba; Yasuo Ikeda; Masataka Kuwana
Neurogenic potential of progenitors derived from human circulating CD14+ monocytes.
Immunology and cell biology 2006;84(2):209-17.
2006: Yukihiko Iizuka; Hidefumi Kojima; Tetsuji Kobata; Takeshi Kawase; Yutaka Kawakami; Masahiro Toda
Identification of a glioma antigen, GARC-1, using cytotoxic T lymphocytes induced by HSV cancer vaccine.
International journal of cancer. Journal international du cancer 2006;118(4):942-9.
2006: M Nakamura; Y Tanaka; T Satoh; M Kawai; Michito Hirakata; Junichi Kaburaki; Yutaka Kawakami; Yasuo Ikeda; Masataka Kuwana
Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism.
Rheumatology (Oxford, England) 2006;45(2):150-6.
2006: Hidetoshi Sumimoto; Kenro Hirata; Shizuko Yamagata; Hiroyuki Miyoshi; Makoto Miyagishi; Kazunari Taira; Yutaka Kawakami
Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi.
International journal of cancer. Journal international du cancer 2006;118(2):472-6.
2006: Takaho Okada; Masanori Akada; Tomonobu Fujita; Takashi Iwata; Yasufumi Goto; Kenji Kido; Tsutomu Okada; Yuriko Matsuzaki; Kouichi Kobayashi; Seiki Matsuno; Makoto Sunamura; Yutaka Kawakami
A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):191-7.
2006: Maiko Matsushita; Rie Yamazaki; Hideyuki Ikeda; Takehiko Mori; Hidetoshi Sumimoto; Tomonobu Fujita; Shinichiro Okamoto; Yasuo Ikeda; Yutaka Kawakami
Possible involvement of allogeneic antigens recognised by donor-derived CD4 cytotoxic T cells in selective GVL effects after stem cell transplantation of patients with haematological malignancy.
British journal of haematology 2006;132(1):56-65.
2005: Shigeaki Suzuki; Takashi Satoh; Hidekata Yasuoka; Yasuhito Hamaguchi; Kortaro Tanaka; Yutaka Kawakami; Norihiro Suzuki; Masataka Kuwana
Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis.
Journal of neuroimmunology 2005;170(1-2):141-9.
2005: Hiroaki Kodama; takafumi inoue; Ryuichi Watanabe; Hidekata Yasuoka; Yutaka Kawakami; Satoshi Ogawa; Yasuo Ikeda; Katsuhiko Mikoshiba; Masataka Kuwana
Cardiomyogenic potential of mesenchymal progenitors derived from human circulating CD14+ monocytes.
Stem cells and development 2005;14(6):676-86.
2005: Yoko Ogawa; Hiroaki Kodama; Kaori Kameyama; Kazuto Yamazaki; Hidekata Yasuoka; Shinichiro Okamoto; Hidetoshi Inoko; Yutaka Kawakami; Masataka Kuwana
Donor fibroblast chimerism in the pathogenic fibrotic lesion of human chronic graft-versus-host disease.
Investigative ophthalmology & visual science 2005;46(12):4519-27.
2005: Mutsuko Ohnishi; Toshiharu Sakurai; Yuji Heike; Rie Yamazaki; Yoshinobu Kanda; Yoichi Takaue; Hideaki Mizoguchi; Yutaka Kawakami
Evaluation of cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic haematopoietic stem cell transplantation using interferon-gamma-enzyme-linked immunospot and human leucocyte antigen tetramer assays with an immunodominant T-cell epitope.
British journal of haematology 2005;131(4):472-9.
2005: Takaho Okada; Shinobu Noji; Yasufumi Goto; Takashi Iwata; Tomonobu Fujita; Tsutomu Okada; Yuriko Matsuzaki; Masataka Kuwana; Michito Hirakata; Akira Horii; Seiki Matsuno; Makoto Sunamura; Yutaka Kawakami
Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis.
International journal of cancer. Journal international du cancer 2005;116(6):925-33.
2005: Yutaka Kawakami; Hidetoshi Sumimoto; Tomonobu Fujita; Yuriko Matsuzaki
Immunological detection of altered signaling molecules involved in melanoma development.
Cancer metastasis reviews 2005;24(2):357-66.
2005: Takashi Iwata; Tomonobu Fujita; Nobumaru Hirao; Yuriko Matsuzaki; Tsutomu Okada; Hiroshi Mochimaru; Nobuyuki Susumu; Eri Matsumoto; Kokichi Sugano; Naohide Yamashita; Shiro Nozawa; Yutaka Kawakami
Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability-positive endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3949-57.
2005: Yutaka Kawakami
[Identification of human tumor antigens recognized by T cells].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():562-7.
2005: Takashi Inozume; Yuriko Matsuzaki; Sachiko Kurihara; Tomonobu Fujita; Akifumi Yamamoto; Hiroyuki Aburatani; Shinji Shimada; Yutaka Kawakami
Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.
International journal of cancer. Journal international du cancer 2005;114(2):283-90.
2005: Masataka Kuwana; Eiji Matsuura; Kazuko Kobayashi; Yuka Okazaki; Junichi Kaburaki; Yasuo Ikeda; Yutaka Kawakami
Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells.
Blood 2005;105(4):1552-7.
2005: T Satoh; K Kimura; Y Okano; Michito Hirakata; Yutaka Kawakami; Masataka Kuwana
Lack of circulating autoantibodies to bone morphogenetic protein receptor-II or activin receptor-like kinase 1 in mixed connective tissue disease patients with pulmonary arterial hypertension.
Rheumatology (Oxford, England) 2005;44(2):192-6.
2005: Yuriko Matsuzaki; Shin-ichi Hashimoto; Tomonobu Fujita; Takuji Suzuki; Toshiharu Sakurai; Kouji Matsushima; Yutaka Kawakami
Systematic identification of human melanoma antigens using serial analysis of gene expression (SAGE).
Journal of immunotherapy (Hagerstown, Md. : 1997) 2005;28(1):10-9.
2004: Hidekata Yasuoka; Yuka Okazaki; Yutaka Kawakami; Michito Hirakata; Hidetoshi Inoko; Yasuo Ikeda; Masataka Kuwana
Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behçet's disease.
Arthritis and rheumatism 2004;50(11):3658-62.
2004: Yohei Ohashi; Masakazu Ueda; Takeshi Kawase; Yutaka Kawakami; Masahiro Toda
Identification of an epigenetically silenced gene, RFX1, in human glioma cells using restriction landmark genomic scanning.
Oncogene 2004;23(47):7772-9.
2004: Yutaka Kawakami; Tomonobu Fujita; Yuriko Matsuzaki; Toshiharu Sakurai; Makoto Tsukamoto; Masahiro Toda; Hidetoshi Sumimoto
Identification of human tumor antigens and its implications for diagnosis and treatment of cancer.
Cancer science 2004;95(10):784-91.
2004: Masataka Kuwana; Yuka Okazaki; Hidekata Yasuoka; Yutaka Kawakami; Yasuo Ikeda
Defective vasculogenesis in systemic sclerosis.
Lancet 2004;364(9434):603-10.
2004: Hidetoshi Sumimoto; Makoto Miyagishi; Hiroyuki Miyoshi; Shizuko Yamagata; Ayako Shimizu; Kazunari Taira; Yutaka Kawakami
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.
Oncogene 2004;23(36):6031-9.
2004: Yuji Mikami; Hideyuki Okano; Masanori Sakaguchi; Masaya Nakamura; Takuya Shimazaki; Hirotaka James Okano; Yutaka Kawakami; Yoshiaki Toyama; Masahiro Toda
Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery.
Journal of neuroscience research 2004;76(4):453-65.
2004: Yutaka Kawakami
[Development of immunotherapy for cancer: lessons from melanoma research].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2004;27(2):87-98.
2004: Yutaka Kawakami; Takaho Okada; Masanori Akada
Development of immunotherapy for pancreatic cancer.
Pancreas 2004;28(3):320-5.
2004: Takashi Satoh; Janardan P Pandey; Yuka Okazaki; Hidekata Yasuoka; Yutaka Kawakami; Yasuo Ikeda; Masataka Kuwana
Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura.
British journal of haematology 2004;124(6):796-801.
2004: Yukihiko Iizuka; Ayuko Suzuki; Yutaka Kawakami; Masahiro Toda
Augmentation of antitumor immune responses by multiple intratumoral inoculations of replication-conditional HSV and interleukin-12.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2004;27(2):92-8.
2004: Keiichi Ito; Tomonobu Fujita; Masanori Akada; Yukiko Kiniwa; Makoto Tsukamoto; Aiko Yamamoto; Yuriko Matsuzaki; Maiko Matsushita; Takako Asano; Jun Nakashima; Masaaki Tachibana; Masamichi Hayakawa; Hideyuki Ikeda; Masaru Murai; Yutaka Kawakami
Identification of bladder cancer antigens recognized by IgG antibodies of a patient with metastatic bladder cancer.
International journal of cancer. Journal international du cancer 2004;108(5):712-24.
2004: Ryo Ueda; Yukihiko Iizuka; Kazunari Yoshida; Takeshi Kawase; Yutaka Kawakami; Masahiro Toda
Identification of a human glioma antigen, SOX6, recognized by patients' sera.
Oncogene 2004;23(7):1420-7.
2004: Ryo Ueda; Kazunari Yoshida; Yutaka Kawakami; Takeshi Kawase; Masahiro Toda
Immunohistochemical analysis of SOX6 expression in human brain tumors.
Brain tumor pathology 2004;21(3):117-20.
2004: Ryo Ueda; Kazunari Yoshida; Yutaka Kawakami; Takeshi Kawase; Masahiro Toda
Expression of a transcriptional factor, SOX6, in human gliomas.
Brain tumor pathology 2004;21(1):35-8.
2004: Maiko Matsushita; Rie Yamazaki; Yutaka Kawakami
Quantitative analysis of PRAME for detection of minimal residual disease in leukemia.
Methods in molecular medicine 2004;97():267-75.
2003: Hidekata Yasuoka; Hironobu Ihn; Thomas A Medsger; Michito Hirakata; Yutaka Kawakami; Yasuo Ikeda; Masataka Kuwana
A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6883-90.
2003: Masataka Kuwana; Janardan P Pandey; Richard M Silver; Yutaka Kawakami; Junichi Kaburaki
HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities.
The Journal of rheumatology 2003;30(11):2392-7.
2003: Masataka Kuwana; Yuka Okazaki; Hiroaki Kodama; Keisuke Izumi; Hidekata Yasuoka; Yoko Ogawa; Yutaka Kawakami; Yasuo Ikeda
Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation.
Journal of leukocyte biology 2003;74(5):833-45.
2003: Toshiaki Ishikawa; Tomonobu Fujita; Yuriko Suzuki; Satoshi Okabe; Yasuhito Yuasa; Takehisa Iwai; Yutaka Kawakami
Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability.
Cancer research 2003;63(17):5564-72.
2003: Yutaka Kawakami
Identification of human tumor antigens recognized by T-cells and their use for immunotherapy.
International journal of hematology 2003;77(5):427-34.
2003: Mikio Kajihara; Shinzo Kato; Yuka Okazaki; Yutaka Kawakami; Hiromasa Ishii; Yasuo Ikeda; Masataka Kuwana
A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis.
Hepatology (Baltimore, Md.) 2003;37(6):1267-76.
2003: Hideyuki Ikeda; Maiko Matsushita; Quinten Waisfisz; Akitoshi Kinoshita; Anneke B Oostra; A W M Nieuwint; Johan P de Winter; Maureen Hoatlin; Yohko Kawai; Masao S Sasaki; Alan D D'Andrea; Yutaka Kawakami; Hans Joenje
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2.
Cancer research 2003;63(10):2688-94.
2003: Yoko Ogawa; Masataka Kuwana; Kazuto Yamazaki; Yukihiko Mashima; Masakazu Yamada; Takehiko Mori; Shinichiro Okamoto; Yoshihisa Oguchi; Yutaka Kawakami
Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease.
Investigative ophthalmology & visual science 2003;44(5):1888-96.
2003: Shigeaki Suzuki; Kortaro Tanaka; Hidekata Yasuoka; Yasuo Fukuuchi; Yutaka Kawakami; Masataka Kuwana
Autoreactive T cells to the P3A+ isoform of AChR alpha subunit in myasthenia gravis.
Journal of neuroimmunology 2003;137(1-2):177-86.
2003: Maiko Matsushita; Rie Yamazaki; Hideyuki Ikeda; Yutaka Kawakami
Preferentially expressed antigen of melanoma (PRAME) in the development of diagnostic and therapeutic methods for hematological malignancies.
Leukemia & lymphoma 2003;44(3):439-44.
2003: Masataka Kuwana; Yutaka Kawakami; Yasuo Ikeda
Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura.
Blood 2003;101(2):621-3.
2002: Hidetoshi Sumimoto; Takashi Tsuji; Hiroyuki Miyoshi; Masao Hagihara; Rie Takada-Yamazaki; Shin-ichiro Okamoto; Yasuo Ikeda; Tsuneo Takahashi; Yutaka Kawakami
Rapid and efficient generation of lentivirally gene-modified dendritic cells from DC progenitors with bone marrow stromal cells.
Journal of immunological methods 2002;271(1-2):153-65.
2002: Masataka Kuwana; Kyoko Kimura; Yutaka Kawakami
Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.
Arthritis and rheumatism 2002;46(10):2742-7.
2002: Masataka Kuwana; K Kimura; Michito Hirakata; Yutaka Kawakami; Yasuo Ikeda
Differences in autoantibody response to Th/To between systemic sclerosis and other autoimmune diseases.
Annals of the rheumatic diseases 2002;61(9):842-6.
2002: Masataka Kuwana; Yuka Okazaki; Mikio Kajihara; Junichi Kaburaki; Hiroshi Miyazaki; Yutaka Kawakami; Yasuo Ikeda
Autoantibody to c-Mpl (thrombopoietin receptor) in systemic lupus erythematosus: relationship to thrombocytopenia with megakaryocytic hypoplasia.
Arthritis and rheumatism 2002;46(8):2148-59.
2002: Yuji Mikami; Masahiro Toda; Masahiko Watanabe; Masaya Nakamura; Yoshiaki Toyama; Yutaka Kawakami
A simple and reliable behavioral analysis of locomotor function after spinal cord injury in mice. Technical note.
Journal of neurosurgery 2002;97(1 Suppl):142-7.
2002: Masahiro Toda; Yukihiko Iizuka; Takeshi Kawase; Keiichi Uyemura; Yutaka Kawakami
Immuno-viral therapy of brain tumors by combination of viral therapy with cancer vaccination using a replication-conditional HSV.
Cancer gene therapy 2002;9(4):356-64.
2002: Masataka Kuwana; Yuka Okazaki; Junichi Kaburaki; Yutaka Kawakami; Yasuo Ikeda
Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3675-82.
2002: Kazue Yoshida; Takahide Arai; Junichi Kaburaki; Yasuo Ikeda; Yutaka Kawakami; Masataka Kuwana
Restricted T-cell receptor beta-chain usage by T cells autoreactive to beta(2)-glycoprotein I in patients with antiphospholipid syndrome.
Blood 2002;99(7):2499-504.
2002: Takashi Endo; Masahiro Toda; Masahiko Watanabe; Yukihiko Iizuka; Tetsuro Kubota; Masaki Kitajima; Yutaka Kawakami
In situ cancer vaccination with a replication-conditional HSV for the treatment of liver metastasis of colon cancer.
Cancer gene therapy 2002;9(2):142-8.
2002: Yoko Ogawa; Masataka Kuwana; Kazuto Yamazaki; Yukihiko Mashima; Shinichiro Okamoto; Kazuo Tsubota; Yoshihisa Oguchi; Yutaka Kawakami
Dry eye associated with chronic graft-versus-host disease.
Advances in experimental medicine and biology 2002;506(Pt B):1041-5.
2001: Yukiko Kiniwa; Tomonobu Fujita; Masanori Akada; Keisuke Ito; T Shofuda; Yuriko Suzuki; Aiko Yamamoto; T Saida; Yutaka Kawakami
Tumor antigens isolated from a patient with vitiligo and T-cell-infiltrated melanoma.
Cancer research 2001;61(21):7900-7.
2001: Masataka Kuwana; T Okano; Yoko Ogawa; Junichi Kaburaki; Yutaka Kawakami
Autoantibodies to the amino-terminal fragment of beta-fodrin expressed in glandular epithelial cells in patients with Sjögren's syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5449-56.
2001: Masataka Kuwana; Yutaka Kawakami; Yasuo Ikeda
[Recent topics on basic research for idiopathic thrombocytopenic purpura].
Rinsho byori. The Japanese journal of clinical pathology 2001;49(10):992-5.
2001: K Ishii; Masahiro Toda; Y Nakai; Hiroaki Asou; Masahiko Watanabe; Masaya Nakamura; Y Yato; Y Fujimura; Yutaka Kawakami; Yoshiaki Toyama; Keiichi Uyemura
Increase of oligodendrocyte progenitor cells after spinal cord injury.
Journal of neuroscience research 2001;65(6):500-7.
2001: T Arai; Kazue Yoshida; Junichi Kaburaki; Hidetoshi Inoko; Yasuo Ikeda; Yutaka Kawakami; Masataka Kuwana
Autoreactive CD4(+) T-cell clones to beta2-glycoprotein I in patients with antiphospholipid syndrome: preferential recognition of the major phospholipid-binding site.
Blood 2001;98(6):1889-96.
2001: Masataka Kuwana; Junichi Kaburaki; Timothy M Wright; Yutaka Kawakami; Y Ikeda
Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors.
European journal of immunology 2001;31(9):2547-57.
2001: Shigeaki Suzuki; Masataka Kuwana; Hidekata Yasuoka; Kortaro Tanaka; Yasuo Fukuuchi; Yutaka Kawakami
Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis.
Journal of the neurological sciences 2001;189(1-2):59-64.
2001: Masataka Kuwana; Junichi Kaburaki; H Kitasato; M Kato; S Kawai; Yutaka Kawakami; Yasuo Ikeda
Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura.
Blood 2001;98(1):130-9.
2001: Maiko Matsushita; Hideyuki Ikeda; Masahiro Kizaki; Shinichiro Okamoto; M Ogasawara; Yasuo Ikeda; Yutaka Kawakami
Quantitative monitoring of the PRAME gene for the detection of minimal residual disease in leukaemia.
British journal of haematology 2001;112(4):916-26.
2001: I Toda; Masataka Kuwana; Kazuo Tsubota; Yutaka Kawakami
Lack of evidence for an increased microchimerism in the circulation of patients with Sjögren's syndrome.
Annals of the rheumatic diseases 2001;60(3):248-53.
2001: Yutaka Kawakami; X Wang; T Shofuda; H Sumimoto; J Tupesis; E Fitzgerald; STEVEN ROSENBERG
Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2871-7.
2000: Masataka Kuwana; Yutaka Kawakami; Yasuo Ikeda
[Identification and characterization of pathogenic autoreactive T cells in patients with idiopathic thrombocytopenic purpura].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):555-7.
2000: Masataka Kuwana; Junichi Kaburaki; Janardan P Pandey; Mitsuru Murata; Yutaka Kawakami; Hidetoshi Inoko; Yasuo Ikeda
HLA class II alleles in Japanese patients with immune thrombocytopenic purpura. Associations with anti-platelet glycoprotein autoantibodies and responses to splenectomy.
Tissue antigens 2000;56(4):337-43.
2000: Masataka Kuwana; Junichi Kaburaki; Tsuneyo Mimori; Yutaka Kawakami; T Tojo
Longitudinal analysis of autoantibody response to topoisomerase I in systemic sclerosis.
Arthritis and rheumatism 2000;43(5):1074-84.
2000: Yutaka Kawakami; Yuriko Suzuki; T Shofuda; Yukiko Kiniwa; Takashi Inozume; K Dan; T Sakurai; Tomonobu Fujita
T cell immune responses against melanoma and melanocytes in cancer and autoimmunity.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2000;13 Suppl 8():163-9.
2000: N Hattori; Masataka Kuwana; Junichi Kaburaki; Tsuneyo Mimori; Yasuo Ikeda; Yutaka Kawakami
T cells that are autoreactive to beta2-glycoprotein I in patients with antiphospholipid syndrome and healthy individuals.
Arthritis and rheumatism 2000;43(1):65-75.