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Koichiro Kawashima

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Takeshi Fujii; Yuki Takada-Takatori; Koichiro Kawashima
Regulatory mechanisms of acetylcholine synthesis and release by T cells.
Takeshi Fujii; Kazuhide Horiguchi; Yuki Takada-Takatori; Koichiro Kawashima
Mediatophore regulates acetylcholine release from T cells.
Takeshi Fujii; Manabu Masai; Hidemi Misawa; Takashi Okuda; Yuki Takada-Takatori; Yasuhiro Moriwaki; Tatsuya Haga; Koichiro Kawashima
Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase.

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All Publications

2012: Takeshi Fujii; Yuki Takada-Takatori; Koichiro Kawashima
Regulatory mechanisms of acetylcholine synthesis and release by T cells.
Life sciences 2012;91(21-22):981-5.
2012: Takeshi Fujii; Kazuhide Horiguchi; Yuki Takada-Takatori; Koichiro Kawashima
Mediatophore regulates acetylcholine release from T cells.
Journal of neuroimmunology 2012;244(1-2):16-22.
2009: Takeshi Fujii; Manabu Masai; Hidemi Misawa; Takashi Okuda; Yuki Takada-Takatori; Yasuhiro Moriwaki; Tatsuya Haga; Koichiro Kawashima
Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase.
Journal of neuroscience research 2009;87(13):3024-32.
2008: Koichiro Kawashima; Takeshi Fujii
Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance.
Journal of pharmacological sciences 2008;106(2):167-73.
2008: Takeshi Fujii; Yuki Takada-Takatori; Koichiro Kawashima
Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy.
Journal of pharmacological sciences 2008;106(2):186-92.
2007: Yoshihito X Fujii; Hirofumi Fujigaya; Yasuhiro Moriwaki; Hidemi Misawa; Tadashi Kasahara; Sergei A Grando; Koichiro Kawashima
Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice.
Journal of neuroimmunology 2007;189(1-2):69-74.
2007: Yoshihito X Fujii; Ayako Tashiro; Kumiko Arimoto; Hirofumi Fujigaya; Yasuhiro Moriwaki; Hidemi Misawa; Takeshi Fujii; Minoru MATSUI; Tadashi Kasahara; Koichiro Kawashima
Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice.
Journal of neuroimmunology 2007;188(1-2):80-5.
2007: Koichiro Kawashima; Ken Yoshikawa; Yoshihito X Fujii; Yasuhiro Moriwaki; Hidemi Misawa
Expression and function of genes encoding cholinergic components in murine immune cells.
Life sciences 2007;80(24-25):2314-9.
2007: Koichiro Kawashima; Hidemi Misawa; Yasuhiro Moriwaki; Yoshihito X Fujii; Takeshi Fujii; Yoko Horiuchi; Tomoya Yamada; Tadayuki Imanaka; Masahiro Kamekura
Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems.
Life sciences 2007;80(24-25):2206-9.
2007: Takeshi Fujii; Yuki Takada-Takatori; Koichiro Kawashima
Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity.
Life sciences 2007;80(24-25):2320-4.
2007: Yasuhiro Moriwaki; Ken Yoshikawa; Hiromi Fukuda; Yoshihito X Fujii; Hidemi Misawa; Koichiro Kawashima
Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands.
Life sciences 2007;80(24-25):2365-8.
2006: Takeshi Fujii; Kazuto Masuyama; Koichiro Kawashima
Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways.
Journal of neuroimmunology 2006;179(1-2):101-7.
2005: Tomoya Yamada; Takeshi Fujii; Tamotsu Kanai; Taku Amo; Tadayuki Imanaka; Hiroshi Nishimasu; Takayoshi Wakagi; Hirofumi Shoun; Masahiro Kamekura; Yoichi Kamagata; Takeshi Kato; Koichiro Kawashima
Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea.
Life sciences 2005;77(16):1935-44.
2004: Koichiro Kawashima; Takeshi Fujii
Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function.
Frontiers in bioscience : a journal and virtual library 2004;9():2063-85.
2004: Aya Suenaga; Takeshi Fujii; Hiroshi Ogawa; Takayuki Maruyama; Shuichi Ohuchida; Nobuo Katsube; Takaaki Obata; Koichiro Kawashima
Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP4 receptor agonist, in MOLT-3 human leukemic T cells.
Vascular pharmacology 2004;41(2):51-8.
2004: Takeshi Suzuki; Ryoichi Takagi; Koichiro Kawashima
Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons.
Neuroscience letters 2004;356(1):57-60.
2003: Koichiro Kawashima; Takeshi Fujii
The lymphocytic cholinergic system and its contribution to the regulation of immune activity.
Life sciences 2003;74(6):675-96.
2003: Yoko Horiuchi; Takeshi Fujii; Yuichiro Kamimura; Koichiro Kawashima
The endogenous, immunologically active peptide apelin inhibits lymphocytic cholinergic activity during immunological responses.
Journal of neuroimmunology 2003;144(1-2):46-52.
2003: Takeshi Suzuki; Takeshi Matsugi; Ryoichi Takagi; Koichiro Kawashima
Endogenous glutamatergic synaptic activity elicits acetylcholine release from rat cultured septal cells.
Neuroscience research 2003;47(3):341-7.
2003: Takeshi Fujii; Yoshihiro Watanabe; Tomoyuki Inoue; Koichiro Kawashima
Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses.
Neurochemical research 2003;28(3-4):423-9.
2003: Reika Kimura; Naoki Ushiyama; Takeshi Fujii; Koichiro Kawashima
Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line.
Life sciences 2003;72(18-19):2155-8.
2003: Yuichiro Kamimura; Takeshi Fujii; Hirotatsu Kojima; Tetsuo Nagano; Koichiro Kawashima
Nitric oxide (NO) synthase mRNA expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM, human leukemic T-cell line.
Life sciences 2003;72(18-19):2151-4.
2003: Takeshi Fujii; Takashi Okuda; Tatsuya Haga; Koichiro Kawashima
Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line.
Life sciences 2003;72(18-19):2131-4.
2003: Hiroshi Ogawa; Takeshi Fujii; Yoshihiro Watanabe; Koichiro Kawashima
Expression of multiple mRNA species for choline acetyltransferase in human T-lymphocytes.
Life sciences 2003;72(18-19):2127-30.
2003: Koichiro Kawashima; Takeshi Fujii
The lymphocytic cholinergic system and its biological function.
Life sciences 2003;72(18-19):2101-9.
2003: Yoko Horiuchi; Reika Kimura; Noriko Kato; Takeshi Fujii; Masako Seki; Toyoshige Endo; Takashi Kato; Koichiro Kawashima
Evolutional study on acetylcholine expression.
Life sciences 2003;72(15):1745-56.
2002: Takeshi Fujii; Naoki Ushiyama; Kazuyo Hosonuma; Aya Suenaga; Koichiro Kawashima
Effects of human antithymocyte globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line.
Journal of neuroimmunology 2002;128(1-2):1-8.
2001: Takeshi Suzuki; T Matsugi; Ryoichi Takagi; M Kanagawa; M Hirata; T Nakamura; Y Kudo; Koichiro Kawashima
Functional expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors precedes the development of cholinergic phenotype in embryonic rat septal cells in culture.
Neuroscience letters 2001;311(2):89-92.
2001: K Fujimoto; Minoru Matsui; Takeshi Fujii; Koichiro Kawashima
Decreased acetylcholine content and choline acetyltransferase mRNA expression in circulating mononuclear leukocytes and lymphoid organs of the spontaneously hypertensive rat.
Life sciences 2001;69(14):1629-38.
2001: Takeshi Fujii; Koichiro Kawashima
An independent non-neuronal cholinergic system in lymphocytes.
Japanese journal of pharmacology 2001;85(1):11-5.
2000: Takeshi Fujii; Koichiro Kawashima
Calcium signaling and c-Fos gene expression via M3 muscarinic acetylcholine receptors in human T- and B-cells.
Japanese journal of pharmacology 2000;84(2):124-32.
2000: Takeshi Fujii; H Harada; T Koyama; Y Nakajima; Koichiro Kawashima
Effects of physostigmine and calcium on acetylcholine efflux from the hippocampus of freely moving rats as determined by in vivo microdialysis and a radioimmunoassay.
Neuroscience letters 2000;289(3):181-4.
2000: Takeshi Fujii; Koichiro Kawashima
YM905, a novel M3 antagonist, inhibits Ca2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T cells.
General pharmacology 2000;35(2):71-5.
2000: Takeshi Fujii; Koichiro Kawashima
Ca2+ oscillation and c-fos gene expression induced via muscarinic acetylcholine receptor in human T- and B-cell lines.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(1):14-21.
2000: Takeshi Fujii; K Nakai; Y Nakajima; Koichiro Kawashima
Enhancement of hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by repeated lithium treatment in rats.
Canadian journal of physiology and pharmacology 2000;78(5):392-9.
2000: H Harada; K Hosonuma; Takeshi Fujii; Koichiro Kawashima
Enhancement of cerebral cortical acetylcholine release by intraperitoneal acetic acid and its suppression by analgesics in freely moving rats.
Neuroscience letters 2000;284(3):163-6.
2000: Koichiro Kawashima; Takeshi Fujii
Extraneuronal cholinergic system in lymphocytes.
Pharmacology & therapeutics 2000;86(1):29-48.
1999: Takeshi Fujii; S Ohba; K Nakai; K Fujimoto; T Suzuki; Koichiro Kawashima
Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats.
Japanese journal of pharmacology 1999;80(4):303-9.
1999: H Oosawa; Takeshi Fujii; Koichiro Kawashima
Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells.
Journal of neuroscience research 1999;57(3):381-7.
1999: K Z Sato; Takeshi Fujii; Yoshihiro Watanabe; S Yamada; T Ando; F Kazuko; Koichiro Kawashima
Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.
Neuroscience letters 1999;266(1):17-20.
1999: T Koyama; Y Nakajima; Takeshi Fujii; Koichiro Kawashima
Enhancement of cortical and hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by BAY x 3702 in freely moving rats.
Neuroscience letters 1999;265(1):33-6.
1999: Takeshi Fujii; S Tajima; S Yamada; Yoshihiro Watanabe; K Z Sato; Minoru MATSUI; Hidemi Misawa; Tadashi Kasahara; Koichiro Kawashima
Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines.
Neuroscience letters 1999;259(2):71-4.
1998: K Nakai; Takeshi Fujii; K Fujimoto; Takeshi Suzuki; Koichiro Kawashima
Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis.
Neuroscience research 1998;31(1):23-9.
1998: Takeshi Fujii; S Yamada; Yoshihiro Watanabe; Hidemi Misawa; S Tajima; K Fujimoto; Tadashi Kasahara; Koichiro Kawashima
Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator.
Journal of neuroimmunology 1998;82(1):101-7.
1998: Koichiro Kawashima; Takeshi Fujii; Yoshihiro Watanabe; Hidemi Misawa
Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes.
Life sciences 1998;62(17-18):1701-5.
1997: Takeshi Fujii; M Yoshizawa; K Nakai; K Fujimoto; Takeshi Suzuki; Koichiro Kawashima
Demonstration of the facilitatory role of 8-OH-DPAT on cholinergic transmission in the rat hippocampus using in vivo microdialysis.
Brain research 1997;761(2):244-9.
1997: Takeshi Suzuki; K Nakajima; K Fujimoto; Takeshi Fujii; Koichiro Kawashima
Nitric oxide increases stimulation-evoked acetylcholine release from rat hippocampal slices by a cyclic GMP-independent mechanism.
Brain research 1997;760(1-2):158-62.
1997: Takeshi Fujii; Y Mori; T Tominaga; I Hayasaka; Koichiro Kawashima
Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees.
Neuroscience letters 1997;227(1):21-4.
1997: S Yamada; Takeshi Fujii; Koichiro Kawashima
Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs.
Neuroscience letters 1997;225(1):25-8.
1997: N Yamaguchi; K Fujimoto; Takeshi Fujii; T Suzuki; Koichiro Kawashima
Antihypertensive effect of repeatedly administered YM358, an angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats.
Japanese journal of pharmacology 1997;73(1):83-91.
1996: T Fujii; T Tsuchiya; S Yamada; K Fujimoto; T Suzuki; Tadashi Kasahara; Koichiro Kawashima
Localization and synthesis of acetylcholine in human leukemic T cell lines.
Journal of neuroscience research 1996;44(1):66-72.
1996: Koichiro Kawashima; H Amano; K Fujimoto; Takeshi Suzuki; T Fujii; S Mochizuki; A Tomiyama
Effect of repeated administration of KT3-671, a nonpeptide AT1 receptor antagonist, on diurnal variation in blood pressure, heart rate, and locomotor activity in stroke-prone spontaneously hypertensive rats as determined by radiotelemetry.
Journal of cardiovascular pharmacology 1996;27(3):411-6.
1995: Takeshi Fujii; S Yamada; N Yamaguchi; K Fujimoto; Takeshi Suzuki; Koichiro Kawashima
Species differences in the concentration of acetylcholine, a neurotransmitter, in whole blood and plasma.
Neuroscience letters 1995;201(3):207-10.
1995: Koichiro Kawashima; T Negishi; H Amano; K Fujimoto; Takeshi Suzuki; T Fujii
Antihypertensive effects, determined by a telemetry method, of trichloromethiazide and 7-O-ethylfangchinoline, a derivative of tetrandrine, in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S300-1.
1995: Y Akiba; N Yamaguchi; H Amano; T Fujii; K Fujimoto; Takeshi Suzuki; Koichiro Kawashima
Role of nitric oxide in the control of blood pressure in young and adult spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology. Supplement 1995;22(1):S142-3.
1995: H Amano; K Fujimoto; Takeshi Suzuki; Takeshi Fujii; S Mochizuki; A Tomiyama; Koichiro Kawashima
Antihypertensive effect of chronic KT3-671, a structurally new nonpeptide angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats.
Japanese journal of pharmacology 1995;69(3):215-22.
1994: Takeshi Suzuki; M Kanagawa; Y Takada; K Fujimoto; Koichiro Kawashima
Nerve growth factor treatment induces high-potassium-evoked calcium-dependent acetylcholine release in cultured embryonic rat septal cells.
Brain research 1994;665(2):311-4.
1994: Koichiro Kawashima; A Sato; M Yoshizawa; Takeshi Fujii; K Fujimoto; Takeshi Suzuki
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(5):523-8.
1994: Takeshi Suzuki; H Nonaka; K Fujimoto; Koichiro Kawashima
Tacrine increases stimulation-evoked acetylcholine release from rat hippocampal slices.
Japanese journal of pharmacology 1994;65(4):337-42.
1993: Takeshi Suzuki; Y Kashima; K Fujimoto; Koichiro Kawashima
[3H]2-(4-phenylpiperidino)cyclohexanol (AH5183) binding to synaptosomes and subcellular fractions obtained from rat brain.
Neuroscience letters 1993;157(1):72-4.
1993: Takeshi Suzuki; H Nonaka; K Fujimoto; Koichiro Kawashima
Effects of physostigmine and some nitric oxide-cyclic GMP-related compounds on muscarinic receptor-mediated autoinhibition of hippocampal acetylcholine release.
Journal of neurochemistry 1993;60(6):2285-9.
1992: Takeshi Suzuki; Y Kashima; K Fujimoto; Koichiro Kawashima
Acetylcholine synthesis is modulated by acetylcholine content of cytosolic fraction but not by that of releasable fraction.
Neuroscience letters 1992;144(1-2):127-9.
1991: Koichiro Kawashima; T Hayakawa; Y Kashima; Takeshi Suzuki; K Fujimoto; H Oohata
Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay.
Journal of neurochemistry 1991;57(3):882-7.
1991: Takeshi Suzuki; Y Kashima; K Fujimoto; H Oohata; Koichiro Kawashima
Regional differences in extracellular choline dependency of acetylcholine synthesis in the rat brain.
Neuroscience research 1991;11(1):71-6.
1991: Koichiro Kawashima; H Toda; H Oohata; K Fujimoto; Takeshi Suzuki; O Inagaki
Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats.
General pharmacology 1991;22(2):263-6.
1991: Koichiro Kawashima; T Hayakawa; H Oohata; K Fujimoto; Takeshi Suzuki; T Ogino; Z X Chen
Antihypertensive effect of synthetic tetrandrine derivatives in SHR rats.
General pharmacology 1991;22(1):165-8.
1990: Koichiro Kawashima; N Watanabe; H Oohata; K Fujimoto; Takeshi Suzuki; Y Ishizaki; I Morita; S Murota
Synthesis and release of acetylcholine by cultured bovine arterial endothelial cells.
Neuroscience letters 1990;119(2):156-8.
1990: Koichiro Kawashima; K Fujimoto; Takeshi Suzuki; H Oohata
Pharmacological differentiation of presynaptic M1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum.
General pharmacology 1990;21(1):17-21.
1990: Koichiro Kawashima; T Hayakawa; Y Miwa; H Oohata; Takeshi Suzuki; K Fujimoto; T Ogino; Z X Chen
Structure and hypotensive activity relationships of tetrandrine derivatives in stroke-prone spontaneously hypertensive rats.
General pharmacology 1990;21(3):343-7.
1989: Takeshi Suzuki; Y Kashima; Koichiro Kawashima
Hemicholinium-3-resistant choline uptake system linked to acetylcholine synthesis in the rat hippocampus.
Neuroscience letters 1989;105(1-2):211-4.
1989: Koichiro Kawashima; H Oohata; K Fujimoto; Takeshi Suzuki
Extraneuronal localization of acetylcholine and its release upon nicotinic stimulation in rabbits.
Neuroscience letters 1989;104(3):336-9.
1989: Koichiro Kawashima; T Hayakawa; H Oohata; K Fujimoto; Takeshi Suzuki
Reduction in blood pressure and vascular reactivities to pressor substances by chronic treatment with piretanide in spontaneously hypertensive rats.
General pharmacology 1989;20(2):213-7.
1989: Takeshi Suzuki; K Fujimoto; H Oohata; Koichiro Kawashima
Effects of TRH and DN-1417 on high potassium-evoked acetylcholine release from rat basal forebrain slices determined directly by radioimmunoassay.
General pharmacology 1989;20(2):239-42.
1988: Koichiro Kawashima; K Fujimoto; Takeshi Suzuki; H Oohata
Direct determination of acetylcholine release by radioimmunoassay and presence of presynaptic M1 muscarinic receptors in guinea pig ileum.
The Journal of pharmacology and experimental therapeutics 1988;244(3):1036-9.
1988: Takeshi Suzuki; K Fujimoto; H Oohata; Koichiro Kawashima
Presynaptic M1 muscarinic receptor modulates spontaneous release of acetylcholine from rat basal forebrain slices.
Neuroscience letters 1988;84(2):209-12.
1987: Koichiro Kawashima; H Oohata; K Fujimoto; Takeshi Suzuki
Plasma concentration of acetylcholine in young women.
Neuroscience letters 1987;80(3):339-42.