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Lewis Kay

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Procedures

Biomolecular Nuclear Magnetic Resonance

Phenomena

Concepts & Ideas

Chemicals & Drugs

Physiology

Protein Folding

Occupations

Thermodynamics

Genes & Molecular Sequences

Amino Acid Sequence

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Network (preview)

Co-Publications
Name
36
Forman-Kay, Julie
26
Tugarinov, Vitali
22
Hansen, Flemming
20
Korzhnev, Dmitry
19
Muhandiram, Ranjith
17
Vallurupalli, Pramodh
17
Skrynnikov, Nikolai
16
Mittermaier, Anthony
15
Choy, Wing-Yiu
13
Pawson, Tony
11
Bax, Adriaan
10
Mulder, Frans
10
Farrow, NA
9
Dahlquist, Frederick
9
Hwang, Peter

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Publications

TOP 3
Velyvis Algirdas; Schachman Howard K; Kay Lewis E
Assignment of Ile, Leu, and Val methyl correlations in supra-molecular systems: an application to aspartate transcarbamoylase.
Hansen D Flemming; Feng Haniqiao; Zhou Zheng; Bai Yawen; Kay Lewis E
Selective characterization of microsecond motions in proteins by NMR relaxation.
Baldwin Andrew J; Kay Lewis E
NMR spectroscopy brings invisible protein states into focus.

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All Publications

2009: Velyvis Algirdas; Schachman Howard K; Kay Lewis E
Assignment of Ile, Leu, and Val methyl correlations in supra-molecular systems: an application to aspartate transcarbamoylase.
Journal of the American Chemical Society 2009;131(45):16534-43.
2009: Hansen D Flemming; Feng Haniqiao; Zhou Zheng; Bai Yawen; Kay Lewis E
Selective characterization of microsecond motions in proteins by NMR relaxation.
Journal of the American Chemical Society 2009;131(44):16257-65.
2009: Baldwin Andrew J; Kay Lewis E
NMR spectroscopy brings invisible protein states into focus.
Nature chemical biology 2009;5(11):808-14.
2009: Murphy James M; Hansen D Flemming; Wiesner Silke; Muhandiram D Ranjith; Borg Mikael; Smith Matthew J; Sicheri Frank; Kay Lewis E; Forman-Kay Julie D; Pawson Tony
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
Journal of molecular biology 2009;393(2):409-24.
2009: Hansen D Flemming; Vallurupalli Pramodh; Kay Lewis E
Measurement of methyl group motional parameters of invisible, excited protein states by NMR spectroscopy.
Journal of the American Chemical Society 2009;131(35):12745-54.
2009: Vallurupalli Pramodh; Hansen D Flemming; Lundström Patrik; Kay Lewis E
CPMG relaxation dispersion NMR experiments measuring glycine 1H alpha and 13C alpha chemical shifts in the 'invisible' excited states of proteins.
Journal of biomolecular NMR 2009;45(1-2):45-55.
2009: Baldwin Andrew J; Hansen D Flemming; Vallurupalli Pramodh; Kay Lewis E
Measurement of methyl axis orientations in invisible, excited states of proteins by relaxation dispersion NMR spectroscopy.
Journal of the American Chemical Society 2009;131(33):11939-48.
2009: Auer Renate; Neudecker Philipp; Muhandiram D Ranjith; Lundström Patrik; Hansen D Flemming; Konrat Robert; Kay Lewis E
Measuring the signs of 1H(alpha) chemical shift differences between ground and excited protein states by off-resonance spin-lock R(1rho) NMR spectroscopy.
Journal of the American Chemical Society 2009;131(31):10832-3.
2009: van Ingen Hugo; Korzhnev Dmitry M; Kay Lewis E
An analysis of the effects of 1HN-(1)HN dipolar couplings on the measurement of amide bond vector orientations in invisible protein states by relaxation dispersion NMR.
The journal of physical chemistry. B 2009;113(29):9968-77.
2009: Velyvis Algirdas; Schachman Howard K; Kay Lewis E
Application of methyl-TROSY NMR to test allosteric models describing effects of nucleotide binding to aspartate transcarbamoylase.
Journal of molecular biology 2009;387(3):540-7.
2009: Hansen D Flemming; Zhou Zheng; Feng Haniqiao; Miller Jenkins Lisa M; Bai Yawen; Kay Lewis E
Binding kinetics of histone chaperone Chz1 and variant histone H2A.Z-H2B by relaxation dispersion NMR spectroscopy.
Journal of molecular biology 2009;387(1):1-9.
2009: Neudecker Philipp; Lundström Patrik; Kay Lewis E
Relaxation dispersion NMR spectroscopy as a tool for detailed studies of protein folding.
Biophysical journal 2009;96(6):2045-54.
2009: Lundström Patrik; Hansen D Flemming; Vallurupalli Pramodh; Kay Lewis E
Accurate measurement of alpha proton chemical shifts of excited protein states by relaxation dispersion NMR spectroscopy.
Journal of the American Chemical Society 2009;131(5):1915-26.
2009: Korzhnev Dmitry M; Bezsonova Irina; Lee Soyoung; Chalikian Tigran V; Kay Lewis E
Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy.
Journal of molecular biology 2009;386(2):391-405.
2009: Lundström Patrik; Vallurupalli Pramodh; Hansen D Flemming; Kay Lewis E
Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy.
Nature protocols 2009;4(11):1641-8.
2008: Mittag Tanja; Orlicky Stephen; Choy Wing-Yiu; Tang Xiaojing; Lin Hong; Sicheri Frank; Kay Lewis E; Tyers Mike; Forman-Kay Julie D
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17772-7.
2008: Lundström Patrik; Hansen D Flemming; Kay Lewis E
Measurement of carbonyl chemical shifts of excited protein states by relaxation dispersion NMR spectroscopy: comparison between uniformly and selectively (13)C labeled samples.
Journal of biomolecular NMR 2008;42(1):35-47.
2008: Vallurupalli Pramodh; Hansen D Flemming; Kay Lewis E
Structures of invisible, excited protein states by relaxation dispersion NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11766-71.
2008: Zhou Zheng; Feng Hanqiao; Hansen D Flemming; Kato Hidenori; Luk Ed; Freedberg Daron I; Kay Lewis E; Wu Carl; Bai Yawen
NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
Nature structural & molecular biology 2008;15(8):868-9.
2008: Hansen D Flemming; Vallurupalli Pramodh; Kay Lewis E
Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states.
Journal of biomolecular NMR 2008;41(3):113-20.
2008: Sprangers Remco; Li Xiaoming; Mao Xinliang; Rubinstein John L; Schimmer Aaron D; Kay Lewis E
TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors.
Biochemistry 2008;47(26):6727-34.
2008: Hass Mathias A S; Hansen D Flemming; Christensen Hans E M; Led Jens J; Kay Lewis E
Characterization of conformational exchange of a histidine side chain: protonation, rotamerization, and tautomerization of His61 in plastocyanin from Anabaena variabilis.
Journal of the American Chemical Society 2008;130(26):8460-70.
2008: Hansen D Flemming; Vallurupalli Pramodh; Kay Lewis E
Quantifying two-bond 1HN-13CO and one-bond 1H(alpha)-13C(alpha) dipolar couplings of invisible protein states by spin-state selective relaxation dispersion NMR spectroscopy.
Journal of the American Chemical Society 2008;130(26):8397-405.
2008: Hansen D Flemming; Vallurupalli Pramodh; Kay Lewis E
An improved 15N relaxation dispersion experiment for the measurement of millisecond time-scale dynamics in proteins.
The journal of physical chemistry. B 2008;112(19):5898-904.
2008: Korzhnev Dmitry M; Kay Lewis E
Probing invisible, low-populated States of protein molecules by relaxation dispersion NMR spectroscopy: an application to protein folding.
Accounts of chemical research 2008;41(3):442-51.
2008: Vallurupalli Pramodh; Hansen D Flemming; Kay Lewis E
Probing structure in invisible protein states with anisotropic NMR chemical shifts.
Journal of the American Chemical Society 2008;130(9):2734-5.
2008: Hansen D Flemming; Vallurupalli Pramodh; Lundström Patrik; Neudecker Philipp; Kay Lewis E
Probing chemical shifts of invisible states of proteins with relaxation dispersion NMR spectroscopy: how well can we do?
Journal of the American Chemical Society 2008;130(8):2667-75.
2007: Vallurupalli Pramodh; Hansen D Flemming; Stollar Elliott; Meirovitch Eva; Kay Lewis E
Measurement of bond vector orientations in invisible excited states of proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18473-7.
2007: Sprangers Remco; Kay Lewis E
Probing supramolecular structure from measurement of methyl (1)H-(13)C residual dipolar couplings.
Journal of the American Chemical Society 2007;129(42):12668-9.
2007: Neudecker Philipp; Zarrine-Afsar Arash; Davidson Alan R; Kay Lewis E
Phi-value analysis of a three-state protein folding pathway by NMR relaxation dispersion spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15717-22.
2007: Sprangers Remco; Velyvis Algirdas; Kay Lewis E
Solution NMR of supramolecular complexes: providing new insights into function.
Nature methods 2007;4(9):697-703.
2007: Murphy James M; Korzhnev Dmitry M; Ceccarelli Derek F; Briant Douglas J; Zarrine-Afsar Arash; Sicheri Frank; Kay Lewis E; Pawson Tony
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14336-41.
2007: Hansen D Flemming; Yang Daiwen; Feng Haniqiao; Zhou Zheng; Wiesner Silke; Bai Yawen; Kay Lewis E
An exchange-free measure of 15N transverse relaxation: an NMR spectroscopy application to the study of a folding intermediate with pervasive chemical exchange.
Journal of the American Chemical Society 2007;129(37):11468-79.
2007: Korzhnev Dmitry M; Religa Tomasz L; Lundström Patrik; Fersht Alan R; Kay Lewis E
The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy.
Journal of molecular biology 2007;372(2):497-512.
2007: Tugarinov Vitali; Kay Lewis E
Separating degenerate (1)H transitions in methyl group probes for single-quantum (1)H-CPMG relaxation dispersion NMR spectroscopy.
Journal of the American Chemical Society 2007;129(30):9514-21.
2007: Lundström Patrik; Teilum Kaare; Carstensen Tommy; Bezsonova Irina; Wiesner Silke; Hansen D Flemming; Religa Tomasz L; Akke Mikael; Kay Lewis E
Fractional 13C enrichment of isolated carbons using [1-13C]- or [2- 13C]-glucose facilitates the accurate measurement of dynamics at backbone Calpha and side-chain methyl positions in proteins.
Journal of biomolecular NMR 2007;38(3):199-212.
2007: Velyvis Algirdas; Yang Ying R; Schachman Howard K; Kay Lewis E
A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8815-20.
2007: Lundström Patrik; Vallurupalli Pramodh; Religa Tomasz L; Dahlquist Frederick W; Kay Lewis E
A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity.
Journal of biomolecular NMR 2007;38(1):79-88.
2007: Vallurupalli Pramodh; Scott Lincoln; Williamson James R; Kay Lewis E
Strong coupling effects during X-pulse CPMG experiments recorded on heteronuclear ABX spin systems: artifacts and a simple solution.
Journal of biomolecular NMR 2007;38(1):41-6.
2007: Hansen D Flemming; Kay Lewis E
Improved magnetization alignment schemes for spin-lock relaxation experiments.
Journal of biomolecular NMR 2007;37(4):245-55.
2007: Tugarinov Vitali; Sprangers Remco; Kay Lewis E
Probing side-chain dynamics in the proteasome by relaxation violated coherence transfer NMR spectroscopy.
Journal of the American Chemical Society 2007;129(6):1743-50.
2007: Sprangers Remco; Kay Lewis E
Quantitative dynamics and binding studies of the 20S proteasome by NMR.
Nature 2007;445(7128):618-22.
2006: Neudecker Philipp; Zarrine-Afsar Arash; Choy Wing-Yiu; Muhandiram D Ranjith; Davidson Alan R; Kay Lewis E
Identification of a collapsed intermediate with non-native long-range interactions on the folding pathway of a pair of Fyn SH3 domain mutants by NMR relaxation dispersion spectroscopy.
Journal of molecular biology 2006;363(5):958-76.
2006: Tugarinov Vitali; Kay Lewis E
A 2H NMR relaxation experiment for the measurement of the time scale of methyl side-chain dynamics in large proteins.
Journal of the American Chemical Society 2006;128(38):12484-9.
2006: Korzhnev Dmitry M; Neudecker Philipp; Zarrine-Afsar Arash; Davidson Alan R; Kay Lewis E
Abp1p and Fyn SH3 domains fold through similar low-populated intermediate states.
Biochemistry 2006;45(34):10175-83.
2006: Vallurupalli Pramodh; Kay Lewis E
Complementarity of ensemble and single-molecule measures of protein motion: a relaxation dispersion NMR study of an enzyme complex.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11910-5.
2006: Vallurupalli Pramodh; Scott Lincoln; Hennig Mirko; Williamson James R; Kay Lewis E
New RNA labeling methods offer dramatic sensitivity enhancements in 2H NMR relaxation spectra.
Journal of the American Chemical Society 2006;128(29):9346-7.
2006: Tugarinov Vitali; Ollerenshaw Jason E; Kay Lewis E
Dipolar dynamic frequency shifts in multiple-quantum spectra of methyl groups in proteins: correlation with side-chain motion.
Magnetic resonance in chemistry : MRC 2006;44 Spec No():S122-9.
2006: Evanics Ferenc; Hwang Peter M; Cheng Yao; Kay Lewis E; Prosser R Scott
Topology of an outer-membrane enzyme: Measuring oxygen and water contacts in solution NMR studies of PagP.
Journal of the American Chemical Society 2006;128(25):8256-64.
2006: Tugarinov Vitali; Kay Lewis E
Relaxation rates of degenerate 1H transitions in methyl groups of proteins as reporters of side-chain dynamics.
Journal of the American Chemical Society 2006;128(22):7299-308.
2006: Tollinger Martin; Neale Chris; Kay Lewis E; Forman-Kay Julie D
Characterization of the hydrodynamic properties of the folding transition state of an SH3 domain by magnetization transfer NMR spectroscopy.
Biochemistry 2006;45(20):6434-45.
2006: Brath Ulrika; Akke Mikael; Yang Daiwen; Kay Lewis E; Mulder Frans A A
Functional dynamics of human FKBP12 revealed by methyl 13C rotating frame relaxation dispersion NMR spectroscopy.
Journal of the American Chemical Society 2006;128(17):5718-27.
2006: Mittermaier Anthony; Kay Lewis E
New tools provide new insights in NMR studies of protein dynamics.
Science (New York, N.Y.) 2006;312(5771):224-8.
2006: Korzhnev Dmitry M; Bezsonova Irina; Evanics Ferenc; Taulier Nicolas; Zhou Zheng; Bai Yawen; Chalikian Tigran V; Prosser R Scott; Kay Lewis E
Probing the transition state ensemble of a protein folding reaction by pressure-dependent NMR relaxation dispersion.
Journal of the American Chemical Society 2006;128(15):5262-9.
2006: Bezsonova Irina; Korzhnev Dmitry M; Prosser R Scott; Forman-Kay Julie D; Kay Lewis E
Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR.
Biochemistry 2006;45(15):4711-9.
2006: Neudecker Philipp; Korzhnev Dmitry M; Kay Lewis E
Assessment of the effects of increased relaxation dispersion data on the extraction of 3-site exchange parameters characterizing the unfolding of an SH3 domain.
Journal of biomolecular NMR 2006;34(3):129-35.
2006: Zarrine-Afsar Arash; Mittermaier Anthony; Kay Lewis E; Davidson Alan R
Protein stabilization by specific binding of guanidinium to a functional arginine-binding surface on an SH3 domain.
Protein science : a publication of the Protein Society 2006;15(1):162-70.
2006: Tugarinov Vitali; Kanelis Voula; Kay Lewis E
Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy.
Nature protocols 2006;1(2):749-54.
2005: Tugarinov Vitali; Kay Lewis E
Quantitative 13C and 2H NMR relaxation studies of the 723-residue enzyme malate synthase G reveal a dynamic binding interface.
Biochemistry 2005;44(49):15970-7.
2005: Mittermaier Anthony; Korzhnev Dmitry M; Kay Lewis E
Side-chain interactions in the folding pathway of a Fyn SH3 domain mutant studied by relaxation dispersion NMR spectroscopy.
Biochemistry 2005;44(47):15430-6.
2005: Eisenmesser Elan Z; Millet Oscar; Labeikovsky Wladimir; Korzhnev Dmitry M; Wolf-Watz Magnus; Bosco Daryl A; Skalicky Jack J; Kay Lewis E; Kern Dorothee
Intrinsic dynamics of an enzyme underlies catalysis.
Nature 2005;438(7064):117-21.
2005: Sprangers Remco; Gribun Anna; Hwang Peter M; Houry Walid A; Kay Lewis E
Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16678-83.
2005: Korzhnev Dmitry M; Neudecker Philipp; Mittermaier Anthony; Orekhov Vladislav Yu; Kay Lewis E
Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant.
Journal of the American Chemical Society 2005;127(44):15602-11.
2005: Ollerenshaw Jason E; Tugarinov Vitali; Skrynnikov Nikolai R; Kay Lewis E
Comparison of 13CH3, 13CH2D, and 13CHD2 methyl labeling strategies in proteins.
Journal of biomolecular NMR 2005;33(1):25-41.
2005: Tugarinov Vitali; Kay Lewis E
Methyl groups as probes of structure and dynamics in NMR studies of high-molecular-weight proteins.
Chembiochem : a European journal of chemical biology 2005;6(9):1567-77.
2005: Pufall Miles A; Lee Gregory M; Nelson Mary L; Kang Hyun-Seo; Velyvis Algirdas; Kay Lewis E; McIntosh Lawrence P; Graves Barbara J
Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.
Science (New York, N.Y.) 2005;309(5731):142-5.
2005: Tollinger Martin; Kay Lewis E; Forman-Kay Julie D
Measuring pK(a) values in protein folding transition state ensembles by NMR spectroscopy.
Journal of the American Chemical Society 2005;127(25):8904-5.
2005: Tugarinov Vitali; Ollerenshaw Jason E; Kay Lewis E
Probing side-chain dynamics in high molecular weight proteins by deuterium NMR spin relaxation: an application to an 82-kDa enzyme.
Journal of the American Chemical Society 2005;127(22):8214-25.
2005: Vallurupalli Pramodh; Kay Lewis E
A suite of 2H NMR spin relaxation experiments for the measurement of RNA dynamics.
Journal of the American Chemical Society 2005;127(18):6893-901.
2005: Korzhnev Dmitry M; Mittermaier Anthony K; Kay Lewis E
Cross-correlated spin relaxation effects in methyl 1H CPMG-based relaxation dispersion experiments: complications and a simple solution.
Journal of biomolecular NMR 2005;31(4):337-42.
2005: Choy Wing-Yiu; Zhou Zheng; Bai Yawen; Kay Lewis E
An 15N NMR spin relaxation dispersion study of the folding of a pair of engineered mutants of apocytochrome b562.
Journal of the American Chemical Society 2005;127(14):5066-72.
2005: Kay Lewis E
NMR studies of protein structure and dynamics.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2005;173(2):193-207.
2005: Xu Jun; Millet Oscar; Kay Lewis E; Skrynnikov Nikolai R
A new spin probe of protein dynamics: nitrogen relaxation in 15N-2H amide groups.
Journal of the American Chemical Society 2005;127(9):3220-9.
2005: Tugarinov Vitali; Kay Lewis E; Ibraghimov Ilghiz; Orekhov Vladislav Yu
High-resolution four-dimensional 1H-13C NOE spectroscopy using methyl-TROSY, sparse data acquisition, and multidimensional decomposition.
Journal of the American Chemical Society 2005;127(8):2767-75.
2005: Korzhnev Dmitry M; Orekhov Vladislav Yu; Kay Lewis E
Off-resonance R(1rho) NMR studies of exchange dynamics in proteins with low spin-lock fields: an application to a Fyn SH3 domain.
Journal of the American Chemical Society 2005;127(2):713-21.
2005: Finerty Patrick J; Mittermaier Anthony K; Muhandiram Ranjith; Kay Lewis E; Forman-Kay Julie D
NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain.
Biochemistry 2005;44(2):694-703.
2005: Tugarinov Vitali; Choy Wing-Yiu; Orekhov Vladislav Yu; Kay Lewis E
Solution NMR-derived global fold of a monomeric 82-kDa enzyme.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):622-7.
2005: Hwang Peter M; Kay Lewis E
Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP.
Methods in enzymology 2005;394():335-50.
2004: Tugarinov Vitali; Scheurer Christoph; Brüschweiler Rafael; Kay Lewis E
Estimates of methyl 13C and 1H CSA values (Deltasigma) in proteins from cross-correlated spin relaxation.
Journal of biomolecular NMR 2004;30(4):397-406.
2004: Tugarinov Vitali; Choy Wing-Yiu; Kupce Eriks; Kay Lewis E
Addressing the overlap problem in the quantitative analysis of two dimensional NMR spectra: application to (15)N relaxation measurements.
Journal of biomolecular NMR 2004;30(3):347-52.
2004: Ollerenshaw Jason E; Kaya Hüseyin; Chan Hue Sun; Kay Lewis E
Sparsely populated folding intermediates of the Fyn SH3 domain: matching native-centric essential dynamics and experiment.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14748-53.
2004: Tugarinov Vitali; Kay Lewis E
Stereospecific NMR assignments of prochiral methyls, rotameric states and dynamics of valine residues in malate synthase G.
Journal of the American Chemical Society 2004;126(31):9827-36.
2004: Ahn Victoria E; Lo Eileen I; Engel Christian K; Chen Lu; Hwang Peter M; Kay Lewis E; Bishop Russell E; Privé Gilbert G
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin.
The EMBO journal 2004;23(15):2931-41.
2004: Korzhnev Dmitry M; Salvatella Xavier; Vendruscolo Michele; Di Nardo Ariel A; Davidson Alan R; Dobson Christopher M; Kay Lewis E
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.
Nature 2004;430(6999):586-90.
2004: Tugarinov Vitali; Kay Lewis E
1H,13C-1H,1H dipolar cross-correlated spin relaxation in methyl groups.
Journal of biomolecular NMR 2004;29(3):369-76.
2004: Hwang Peter M; Bishop Russell E; Kay Lewis E
The integral membrane enzyme PagP alternates between two dynamically distinct states.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9618-23.
2004: Korzhnev Dmitry M; Kloiber Karin; Kay Lewis E
Multiple-quantum relaxation dispersion NMR spectroscopy probing millisecond time-scale dynamics in proteins: theory and application.
Journal of the American Chemical Society 2004;126(23):7320-9.
2004: Di Nardo Ariel A; Korzhnev Dmitry M; Stogios Peter J; Zarrine-Afsar Arash; Kay Lewis E; Davidson Alan R
Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7954-9.
2004: Tugarinov Vitali; Sprangers Remco; Kay Lewis E
Line narrowing in methyl-TROSY using zero-quantum 1H-13C NMR spectroscopy.
Journal of the American Chemical Society 2004;126(15):4921-5.
2004: Mittermaier Anthony; Kay Lewis E
The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase.
Protein science : a publication of the Protein Society 2004;13(4):1088-99.
2004: Korzhnev Dmitry M; Kloiber Karin; Kanelis Voula; Tugarinov Vitali; Kay Lewis E
Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme.
Journal of the American Chemical Society 2004;126(12):3964-73.
2004: Tugarinov Vitali; Kay Lewis E
An isotope labeling strategy for methyl TROSY spectroscopy.
Journal of biomolecular NMR 2004;28(2):165-72.
2004: Tugarinov Vitali; Hwang Peter M; Kay Lewis E
Nuclear magnetic resonance spectroscopy of high-molecular-weight proteins.
Annual review of biochemistry 2004;73():107-46.
2003: Ollerenshaw Jason E; Lidar Daniel A; Kay Lewis E
Magnetic resonance realization of decoherence-free quantum computation.
Physical review letters 2003;91(21):217904.
2003: Tugarinov Vitali; Kay Lewis E
Ile, Leu, and Val methyl assignments of the 723-residue malate synthase G using a new labeling strategy and novel NMR methods.
Journal of the American Chemical Society 2003;125(45):13868-78.
2003: Millet Oscar; Hudson Rhea P; Kay Lewis E
The energetic cost of domain reorientation in maltose-binding protein as studied by NMR and fluorescence spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12700-5.
2003: Choy Wing-Yiu; Kay Lewis E
Probing residual interactions in unfolded protein states using NMR spin relaxation techniques: an application to delta131delta.
Journal of the American Chemical Society 2003;125(39):11988-92.
2003: Tugarinov Vitali; Hwang Peter M; Ollerenshaw Jason E; Kay Lewis E
Cross-correlated relaxation enhanced 1H[bond]13C NMR spectroscopy of methyl groups in very high molecular weight proteins and protein complexes.
Journal of the American Chemical Society 2003;125(34):10420-8.
2003: Mittermaier Anthony; Davidson Alan R; Kay Lewis E
Correlation between 2H NMR side-chain order parameters and sequence conservation in globular proteins.
Journal of the American Chemical Society 2003;125(30):9004-5.
2003: Millet Oscar; Mittermaier Anthony; Baker David; Kay Lewis E
The effects of mutations on motions of side-chains in protein L studied by 2H NMR dynamics and scalar couplings.
Journal of molecular biology 2003;329(3):551-63.
2003: Korzhnev Dmitry M; Orekhov Vladislav Yu; Dahlquist Frederick W; Kay Lewis E
Off-resonance R1rho relaxation outside of the fast exchange limit: an experimental study of a cavity mutant of T4 lysozyme.
Journal of biomolecular NMR 2003;26(1):39-48.
2003: Tugarinov Vitali; Kay Lewis E
Side chain assignments of Ile delta 1 methyl groups in high molecular weight proteins: an application to a 46 ns tumbling molecule.
Journal of the American Chemical Society 2003;125(19):5701-6.
2003: Choy Wing-Yiu; Kay Lewis E
Model selection for the interpretation of protein side chain methyl dynamics.
Journal of biomolecular NMR 2003;25(4):325-33.
2003: Tollinger Martin; Crowhurst Karin A; Kay Lewis E; Forman-Kay Julie D
Site-specific contributions to the pH dependence of protein stability.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4545-50.
2003: Tugarinov Vitali; Kay Lewis E
Quantitative NMR studies of high molecular weight proteins: application to domain orientation and ligand binding in the 723 residue enzyme malate synthase G.
Journal of molecular biology 2003;327(5):1121-33.
2003: Choy Wing-Yiu; Shortle David; Kay Lewis E
Side chain dynamics in unfolded protein states: an NMR based 2H spin relaxation study of delta131delta.
Journal of the American Chemical Society 2003;125(7):1748-58.
2002: Mal Tapas K; Ikura Mitsuhiko; Kay Lewis E
The ATCUN domain as a probe of intermolecular interactions: application to calmodulin-peptide complexes.
Journal of the American Chemical Society 2002;124(47):14002-3.
2002: Mal Tapas K; Skrynnikov Nikolai R; Yap Kyoko L; Kay Lewis E; Ikura Mitsuhiko
Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR.
Biochemistry 2002;41(43):12899-906.
2002: Donaldson Logan W; Gish Gerald; Pawson Tony; Kay Lewis E; Forman-Kay Julie D
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14053-8.
2002: Skrynnikov Nikolai R; Dahlquist Frederick W; Kay Lewis E
Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments.
Journal of the American Chemical Society 2002;124(41):12352-60.
2002: Hwang Peter M; Choy Wing-Yiu; Lo Eileen I; Chen Lu; Forman-Kay Julie D; Raetz Christian R H; Privé Gilbert G; Bishop Russell E; Kay Lewis E
Solution structure and dynamics of the outer membrane enzyme PagP by NMR.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13560-5.
2002: Korzhnev Dmitry M; Skrynnikov Nikolai R; Millet Oscar; Torchia Dennis A; Kay Lewis E
An NMR experiment for the accurate measurement of heteronuclear spin-lock relaxation rates.
Journal of the American Chemical Society 2002;124(36):10743-53.
2002: Tugarinov Vitali; Muhandiram Ranjith; Ayed Ayeda; Kay Lewis E
Four-dimensional NMR spectroscopy of a 723-residue protein: chemical shift assignments and secondary structure of malate synthase g.
Journal of the American Chemical Society 2002;124(34):10025-35.
2002: Skrynnikov Nikolai R; Millet Oscar; Kay Lewis E
Deuterium spin probes of side-chain dynamics in proteins. 2. Spectral density mapping and identification of nanosecond time-scale side-chain motions.
Journal of the American Chemical Society 2002;124(22):6449-60.
2002: Millet Oscar; Muhandiram D R; Skrynnikov Nikolai R; Kay Lewis E
Deuterium spin probes of side-chain dynamics in proteins. 1. Measurement of five relaxation rates per deuteron in (13)C-labeled and fractionally (2)H-enriched proteins in solution.
Journal of the American Chemical Society 2002;124(22):6439-48.
2002: Mittermaier Anthony; Kay Lewis E
Effect of deuteration on some structural parameters of methyl groups in proteins as evaluated by residual dipolar couplings.
Journal of biomolecular NMR 2002;23(1):35-45.
2002: Tollinger Martin; Forman-Kay Julie D; Kay Lewis E
Measurement of side-chain carboxyl pK(a) values of glutamate and aspartate residues in an unfolded protein by multinuclear NMR spectroscopy.
Journal of the American Chemical Society 2002;124(20):5714-7.
2002: Mulder Frans A A; Hon Bin; Mittermaier Anthony; Dahlquist Frederick W; Kay Lewis E
Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme.
Journal of the American Chemical Society 2002;124(7):1443-51.
2002: Choy Wing-Yiu; Mulder Frans A A; Crowhurst Karin A; Muhandiram D R; Millett Ian S; Doniach Sebastian; Forman-Kay Julie D; Kay Lewis E
Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques.
Journal of molecular biology 2002;316(1):101-12.
2002: Hwang Peter M; Li Chengjun; Morra Massimo; Lillywhite Jennifer; Muhandiram D Ranjith; Gertler Frank; Terhorst Cox; Kay Lewis E; Pawson Tony; Forman-Kay Julie D; Li Shun-Cheng
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
The EMBO journal 2002;21(3):314-23.
2001: Kanelis V; Forman-Kay J D; Kay L E
Multidimensional NMR methods for protein structure determination.
IUBMB life 2001;52(6):291-302.
2001: Tollinger M; Skrynnikov N R; Mulder F A; Forman-Kay J D; Kay L E
Slow dynamics in folded and unfolded states of an SH3 domain.
Journal of the American Chemical Society 2001;123(46):11341-52.
2001: Mulder F A; Mittermaier A; Hon B; Dahlquist F W; Kay L E
Studying excited states of proteins by NMR spectroscopy.
Nature structural biology 2001;8(11):932-5.
2001: Donaldson L W; Skrynnikov N R; Choy W Y; Muhandiram D R; Sarkar B; Forman-Kay J D; Kay L E
Structural characterization of proteins with an attached ATCUN motif by paramagnetic relaxation enhancement NMR spectroscopy.
Journal of the American Chemical Society 2001;123(40):9843-7.
2001: Choy W Y; Tollinger M; Mueller G A; Kay L E
Direct structure refinement of high molecular weight proteins against residual dipolar couplings and carbonyl chemical shift changes upon alignment: an application to maltose binding protein.
Journal of biomolecular NMR 2001;21(1):31-40.
2001: Ayed A; Mulder F A; Yi G S; Lu Y; Kay L E; Arrowsmith C H
Latent and active p53 are identical in conformation.
Nature structural biology 2001;8(9):756-60.
2001: Mittermaier A; Kay L E
Chi1 torsion angle dynamics in proteins from dipolar couplings.
Journal of the American Chemical Society 2001;123(28):6892-903.
2001: Evenäs J; Tugarinov V; Skrynnikov N R; Goto N K; Muhandiram R; Kay L E
Ligand-induced structural changes to maltodextrin-binding protein as studied by solution NMR spectroscopy.
Journal of molecular biology 2001;309(4):961-74.
2001: Skrynnikov N R; Mulder F A; Hon B; Dahlquist F W; Kay L E
Probing slow time scale dynamics at methyl-containing side chains in proteins by relaxation dispersion NMR measurements: application to methionine residues in a cavity mutant of T4 lysozyme.
Journal of the American Chemical Society 2001;123(19):4556-66.
2001: Hwang P M; Skrynnikov N R; Kay L E
Domain orientation in beta-cyclodextrin-loaded maltose binding protein: diffusion anisotropy measurements confirm the results of a dipolar coupling study.
Journal of biomolecular NMR 2001;20(1):83-8.
2001: Goto N K; Skrynnikov N R; Dahlquist F W; Kay L E
What is the average conformation of bacteriophage T4 lysozyme in solution? A domain orientation study using dipolar couplings measured by solution NMR.
Journal of molecular biology 2001;308(4):745-64.
2001: Evenäs J; Mittermaier A; Yang D; Kay L E
Measurement of (13)C(alpha)-(13)C(beta) dipolar couplings in (15)N,(13)C,(2)H-labeled proteins: application to domain orientation in maltose binding protein.
Journal of the American Chemical Society 2001;123(12):2858-64.
2001: Tolman J R; Al-Hashimi H M; Kay L E; Prestegard J H
Structural and dynamic analysis of residual dipolar coupling data for proteins.
Journal of the American Chemical Society 2001;123(7):1416-24.
2001: Mulder F A; Skrynnikov N R; Hon B; Dahlquist F W; Kay L E
Measurement of slow (micros-ms) time scale dynamics in protein side chains by (15)N relaxation dispersion NMR spectroscopy: application to Asn and Gln residues in a cavity mutant of T4 lysozyme.
Journal of the American Chemical Society 2001;123(5):967-75.
2001: Kay L E
Nuclear magnetic resonance methods for high molecular weight proteins: a study involving a complex of maltose binding protein and beta-cyclodextrin.
Methods in enzymology 2001;339():174-203.
2000: Skrynnikov N R; Kay L E
Assessment of molecular structure using frame-independent orientational restraints derived from residual dipolar couplings.
Journal of biomolecular NMR 2000;18(3):239-52.
2000: Mueller G A; Choy W Y; Skrynnikov N R; Kay L E
A method for incorporating dipolar couplings into structure calculations in cases of (near) axial symmetry of alignment.
Journal of biomolecular NMR 2000;18(3):183-8.
2000: Mulder F A; Ayed A; Yang D; Arrowsmith C H; Kay L E
Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy.
Journal of biomolecular NMR 2000;18(2):173-6.
2000: Goto N K; Kay L E
New developments in isotope labeling strategies for protein solution NMR spectroscopy.
Current opinion in structural biology 2000;10(5):585-92.
2000: Mulder F A; Hon B; Muhandiram D R; Dahlquist F W; Kay L E
Flexibility and ligand exchange in a buried cavity mutant of T4 lysozyme studied by multinuclear NMR.
Biochemistry 2000;39(41):12614-22.
2000: Mueller G A; Choy W Y; Yang D; Forman-Kay J D; Venters R A; Kay L E
Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
Journal of molecular biology 2000;300(1):197-212.
2000: Zwahlen C; Li S C; Kay L E; Pawson T; Forman-Kay J D
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.
The EMBO journal 2000;19(7):1505-15.
2000: Varani L; Gunderson S I; Mattaj I W; Kay L E; Neuhaus D; Varani G
The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.
Nature structural biology 2000;7(4):329-35.
2000: Kanelis V; Donaldson L; Muhandiram D R; Rotin D; Forman-Kay J D; Kay L E
Sequential assignment of proline-rich regions in proteins: application to modular binding domain complexes.
Journal of biomolecular NMR 2000;16(3):253-9.
2000: Skrynnikov N R; Goto N K; Yang D; Choy W Y; Tolman J R; Mueller G A; Kay L E
Orienting domains in proteins using dipolar couplings measured by liquid-state NMR: differences in solution and crystal forms of maltodextrin binding protein loaded with beta-cyclodextrin.
Journal of molecular biology 2000;295(5):1265-73.
1999: Li S C; Gish G; Yang D; Coffey A J; Forman-Kay J D; Ernberg I; Kay L E; Pawson T
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.
Current biology : CB 1999;9(23):1355-62.
1999: Mittermaier A; Varani L; Muhandiram D R; Kay L E; Varani G
Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein.
Journal of molecular biology 1999;294(4):967-79.
1999: Goto N K; Gardner K H; Mueller G A; Willis R C; Kay L E
A robust and cost-effective method for the production of Val, Leu, Ile (delta 1) methyl-protonated 15N-, 13C-, 2H-labeled proteins.
Journal of biomolecular NMR 1999;13(4):369-74.
1998: Li S C; Zwahlen C; Vincent S J; McGlade C J; Kay L E; Pawson T; Forman-Kay J D
Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.
Nature structural biology 1998;5(12):1075-83.
1998: Liu D; Ishima R; Tong K I; Bagby S; Kokubo T; Muhandiram D R; Kay L E; Nakatani Y; Ikura M
Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP.
Cell 1998;94(5):573-83.
1998: Kay L E
Protein dynamics from NMR.
Nature structural biology 1998;5 Suppl():513-7.
1998: Shan X; Gardner K H; Muhandiram D R; Kay L E; Arrowsmith C H
Subunit-specific backbone NMR assignments of a 64 kDa trp repressor/DNA complex: a role for N-terminal residues in tandem binding.
Journal of biomolecular NMR 1998;11(3):307-18.
1998: Legault P; Li J; Mogridge J; Kay L E; Greenblatt J
NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif.
Cell 1998;93(2):289-99.
1998: Yang D; Mittermaier A; Mok Y K; Kay L E
A study of protein side-chain dynamics from new 2H auto-correlation and 13C cross-correlation NMR experiments: application to the N-terminal SH3 domain from drk.
Journal of molecular biology 1998;276(5):939-54.
1998: Zwahlen C; Vincent S J; Kay L E
Analytical description of the effect of adiabatic pulses on IS, I2S, and I3S spin systems.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1998;130(2):169-75.
1998: Kay L E; Muhandiram D R; Wolf G; Shoelson S E; Forman-Kay J D
Correlation between binding and dynamics at SH2 domain interfaces.
Nature structural biology 1998;5(2):156-63.
1998: Mogridge J; Legault P; Li J; Van Oene M D; Kay L E; Greenblatt J
Independent ligand-induced folding of the RNA-binding domain and two functionally distinct antitermination regions in the phage lambda N protein.
Molecular cell 1998;1(2):265-75.
1998: Greenblatt J; Mah T F; Legault P; Mogridge J; Li J; Kay L E
Structure and mechanism in transcriptional antitermination by the bacteriophage lambda N protein.
Cold Spring Harbor symposia on quantitative biology 1998;63():327-36.
1998: Kanelis V; Farrow N A; Kay L E; Rotin D; Forman-Kay J D
NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(2-3):341-50.
1998: Kay L E
Protein dynamics from NMR.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(2-3):145-52.
1998: Gardner K H; Kay L E
The use of 2H, 13C, 15N multidimensional NMR to study the structure and dynamics of proteins.
Annual review of biophysics and biomolecular structure 1998;27():357-406.
1997: Yang D; Mok Y K; Forman-Kay J D; Farrow N A; Kay L E
Contributions to protein entropy and heat capacity from bond vector motions measured by NMR spin relaxation.
Journal of molecular biology 1997;272(5):790-804.
1997: Kay L E; Gardner K H
Solution NMR spectroscopy beyond 25 kDa.
Current opinion in structural biology 1997;7(5):722-31.
1997: Zhang O; Kay L E; Shortle D; Forman-Kay J D
Comprehensive NOE characterization of a partially folded large fragment of staphylococcal nuclease Delta131Delta, using NMR methods with improved resolution.
Journal of molecular biology 1997;272(1):9-20.
1997: Li S C; Songyang Z; Vincent S J; Zwahlen C; Wiley S; Cantley L; Kay L E; Forman-Kay J; Pawson T
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7204-9.
1997: Konrat R; Muhandiram D R; Farrow N A; Kay L E
Pulse schemes for the measurement of 3JC'C gamma and 3JNC gamma scalar couplings in 15N,13C uniformly labeled proteins.
Journal of biomolecular NMR 1997;9(4):409-22.
1997: Farrow N A; Zhang O; Forman-Kay J D; Kay L E
Characterization of the backbone dynamics of folded and denatured states of an SH3 domain.
Biochemistry 1997;36(9):2390-402.
1997: Zhang O; Forman-Kay J D; Shortle D; Kay L E
Triple-resonance NOESY-based experiments with improved spectral resolution: applications to structural characterization of unfolded, partially folded and folded proteins.
Journal of biomolecular NMR 1997;9(2):181-200.
1997: Gardner K H; Rosen M K; Kay L E
Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR.
Biochemistry 1997;36(6):1389-401.
1997: Kay L E
NMR methods for the study of protein structure and dynamics.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1997;75(1):1-15.
1996: Rao N S; Legault P; Muhandiram D R; Greenblatt J; Battiste J L; Williamson J R; Kay L E
NMR pulse schemes for the sequential assignment of arginine side-chain H epsilon protons.
Journal of magnetic resonance. Series B 1996;113(3):272-6.
1996: Rosen M K; Gardner K H; Willis R C; Parris W E; Pawson T; Kay L E
Selective methyl group protonation of perdeuterated proteins.
Journal of molecular biology 1996;263(5):627-36.
1996: Yang D; Kay L E
Contributions to conformational entropy arising from bond vector fluctuations measured from NMR-derived order parameters: application to protein folding.
Journal of molecular biology 1996;263(2):369-82.
1996: Battiste J L; Mao H; Rao N S; Tan R; Muhandiram D R; Kay L E; Frankel A D; Williamson J R
Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex.
Science (New York, N.Y.) 1996;273(5281):1547-51.
1996: Anafi M; Rosen M K; Gish G D; Kay L E; Pawson T
A potential SH3 domain-binding site in the Crk SH2 domain.
The Journal of biological chemistry 1996;271(35):21365-74.
1996: McEvoy M M; Muhandiram D R; Kay L E; Dahlquist F W
Structure and dynamics of a CheY-binding domain of the chemotaxis kinase CheA determined by nuclear magnetic resonance spectroscopy.
Biochemistry 1996;35(18):5633-40.
1996: Williams K A; Farrow N A; Deber C M; Kay L E
Structure and dynamics of bacteriophage IKe major coat protein in MPG micelles by solution NMR.
Biochemistry 1996;35(16):5145-57.
1996: Kay L E; Muhandiram D R; Farrow N A; Aubin Y; Forman-Kay J D
Correlation between dynamics and high affinity binding in an SH2 domain interaction.
Biochemistry 1996;35(2):361-8.
1995: Pascal S M; Singer A U; Yamazaki T; Kay L E; Forman-Kay J D
Structural and dynamic characterization of an SH2 domain-phosphopeptide complex by NMR approaches.
Biochemical Society transactions 1995;23(4):729-33.
1995: Kay L E
Field gradient techniques in NMR spectroscopy.
Current opinion in structural biology 1995;5(5):674-81.
1995: McEvoy M M; Zhou H; Roth A F; Lowry D F; Morrison T B; Kay L E; Dahlquist F W
Nuclear magnetic resonance assignments and global fold of a CheY-binding domain in CheA, the chemotaxis-specific kinase of Escherichia coli.
Biochemistry 1995;34(42):13871-80.
1995: Farrow N A; Zhang O; Szabo A; Torchia D A; Kay L E
Spectral density function mapping using 15N relaxation data exclusively.
Journal of biomolecular NMR 1995;6(2):153-62.
1995: Pascal S M; Yamazaki T; Singer A U; Kay L E; Forman-Kay J D
Structural and dynamic characterization of the phosphotyrosine binding region of a Src homology 2 domain--phosphopeptide complex by NMR relaxation, proton exchange, and chemical shift approaches.
Biochemistry 1995;34(36):11353-62.
1995: Xu G Y; Ong E; Gilkes N R; Kilburn D G; Muhandiram D R; Harris-Brandts M; Carver J P; Kay L E; Harvey T S
Solution structure of a cellulose-binding domain from Cellulomonas fimi by nuclear magnetic resonance spectroscopy.
Biochemistry 1995;34(21):6993-7009.
1995: Rosen M K; Yamazaki T; Gish G D; Kay C M; Pawson T; Kay L E
Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein.
Nature 1995;374(6521):477-9.
1995: Farrow N A; Zhang O; Forman-Kay J D; Kay L E
Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer.
Biochemistry 1995;34(3):868-78.
1994: Zhang O; Kay L E; Olivier J P; Forman-Kay J D
Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques.
Journal of biomolecular NMR 1994;4(6):845-58.
1994: Farrow N A; Zhang O; Forman-Kay J D; Kay L E
A heteronuclear correlation experiment for simultaneous determination of 15N longitudinal decay and chemical exchange rates of systems in slow equilibrium.
Journal of biomolecular NMR 1994;4(5):727-34.
1994: Lee W; Revington M J; Arrowsmith C; Kay L E
A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes.
FEBS letters 1994;350(1):87-90.
1994: Pascal S M; Singer A U; Gish G; Yamazaki T; Shoelson S E; Pawson T; Kay L E; Forman-Kay J D
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell 1994;77(3):461-72.
1994: Farrow N A; Muhandiram R; Singer A U; Pascal S M; Kay C M; Gish G; Shoelson S E; Pawson T; Forman-Kay J D; Kay L E
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation.
Biochemistry 1994;33(19):5984-6003.
1994: Bagby S; Harvey T S; Kay L E; Eagle S G; Inouye S; Ikura M
Unusual helix-containing greek keys in development-specific Ca(2+)-binding protein S. 1H, 15N, and 13C assignments and secondary structure determined with the use of multidimensional double and triple resonance heteronuclear NMR spectroscopy.
Biochemistry 1994;33(9):2409-21.
1992: Barbato G; Ikura M; Kay L E; Pastor R W; Bax A
Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.
Biochemistry 1992;31(23):5269-78.
1991: Ikura M; Spera S; Barbato G; Kay L E; Krinks M; Bax A
Secondary structure and side-chain 1H and 13C resonance assignments of calmodulin in solution by heteronuclear multidimensional NMR spectroscopy.
Biochemistry 1991;30(38):9216-28.
1991: Ikura M; Kay L E; Bax A
Improved three-dimensional 1H-13C-1H correlation spectroscopy of a 13C-labeled protein using constant-time evolution.
Journal of biomolecular NMR 1991;1(3):299-304.
1991: Ikura M; Kay L E; Krinks M; Bax A
Triple-resonance multidimensional NMR study of calmodulin complexed with the binding domain of skeletal muscle myosin light-chain kinase: indication of a conformational change in the central helix.
Biochemistry 1991;30(22):5498-504.
1991: Kay L E; Forman-Kay J D; McCubbin W D; Kay C M
Solution structure of a polypeptide dimer comprising the fourth Ca(2+)-binding site of troponin C by nuclear magnetic resonance spectroscopy.
Biochemistry 1991;30(17):4323-33.
1991: Clore G M; Kay L E; Bax A; Gronenborn A M
Four-dimensional 13C/13C-edited nuclear Overhauser enhancement spectroscopy of a protein in solution: application to interleukin 1 beta.
Biochemistry 1991;30(1):12-8.
1991: Bax A; Ikura M; Kay L E; Barbato G; Spera S
Multidimensional triple resonance NMR spectroscopy of isotopically uniformly enriched proteins: a powerful new strategy for structure determination.
Ciba Foundation symposium 1991;161():108-19; discussion 119-35.
1990: Kay L E; Clore G M; Bax A; Gronenborn A M
Four-dimensional heteronuclear triple-resonance NMR spectroscopy of interleukin-1 beta in solution.
Science (New York, N.Y.) 1990;249(4967):411-4.
1990: Ikura M; Marion D; Kay L E; Shih H; Krinks M; Klee C B; Bax A
Heteronuclear 3D NMR and isotopic labeling of calmodulin. Towards the complete assignment of the 1H NMR spectrum.
Biochemical pharmacology 1990;40(1):153-60.
1990: Ikura M; Kay L E; Bax A
A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin.
Biochemistry 1990;29(19):4659-67.
1990: Forman-Kay J E; Gronenborn A M; Kay L E; Wingfield P T; Clore G M
Studies on the solution conformation of human thioredoxin using heteronuclear 15N-1H nuclear magnetic resonance spectroscopy.
Biochemistry 1990;29(6):1566-72.
1989: Kay L E; Torchia D A; Bax A
Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease.
Biochemistry 1989;28(23):8972-9.
1989: Marion D; Driscoll P C; Kay L E; Wingfield P T; Bax A; Gronenborn A M; Clore G M
Overcoming the overlap problem in the assignment of 1H NMR spectra of larger proteins by use of three-dimensional heteronuclear 1H-15N Hartmann-Hahn-multiple quantum coherence and nuclear Overhauser-multiple quantum coherence spectroscopy: application to interleukin 1 beta.
Biochemistry 1989;28(15):6150-6.

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