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Nobuhiko Kayagaki

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Leukemia L5178

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Yan Qu; David Arnott; James E Cupp; Laurie L Gilmour; Anita Izrael-Tomasevic; Nobuhiko Kayagaki; László Kömüves; Mohamed Lamkanfi; Jinfeng Liu; Salina Louie; Shahram Misaghi; Denise M Monack; Kim Newton; Xiaodong Huang
Phosphorylation of NLRC4 is critical for inflammasome activation.
Petr Broz; Vishva M Dixit; Nobuhiko Kayagaki; Kamila Belhocine; Donna M Bouley; Thomas Ruby; Denise M Monack
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Oscar W Huang; Sarah G Hymowitz; Nobuhiko Kayagaki; Xiaolei Ma; Till Maurer; Qui T Phung; Melissa A Starovasnik; JianPing Yin; David Arnott; Ivan Bosanac; Vishva M Dixit; Jeremy Flinders; Andrea G Cochran
Phosphorylation-dependent activity of the deubiquitinase DUBA.

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All Publications

2012: Yan Qu; David Arnott; James E Cupp; Laurie L Gilmour; Anita Izrael-Tomasevic; Nobuhiko Kayagaki; László Kömüves; Mohamed Lamkanfi; Jinfeng Liu; Salina Louie; Shahram Misaghi; Denise M Monack; Kim Newton; Xiaodong Huang
Phosphorylation of NLRC4 is critical for inflammasome activation.
Nature 2012;490(7421):539-42.
2012: Petr Broz; Vishva M Dixit; Nobuhiko Kayagaki; Kamila Belhocine; Donna M Bouley; Thomas Ruby; Denise M Monack
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Nature 2012;490(7419):288-91.
2012: Oscar W Huang; Sarah G Hymowitz; Nobuhiko Kayagaki; Xiaolei Ma; Till Maurer; Qui T Phung; Melissa A Starovasnik; JianPing Yin; David Arnott; Ivan Bosanac; Vishva M Dixit; Jeremy Flinders; Andrea G Cochran
Phosphorylation-dependent activity of the deubiquitinase DUBA.
Nature structural & molecular biology 2012;19(2):171-5.
2011: Nobuhiko Kayagaki; Mohamed Lamkanfi; Wyne P Lee; Jinfeng Liu; Salina Louie; Kim Newton; Yan Qu; Meron Roose-Girma; Søren Warming; Juan Zhang; Lieselotte Vande Walle; Jennifer Dong; Sherry Heldens; Vishva M Dixit
Non-canonical inflammasome activation targets caspase-11.
Nature 2011;479(7371):117-21.
2010: Jonathan W Jones; Nobuhiko Kayagaki; Petr Broz; Thomas Henry; Kim Newton; Karen O'Rourke; Salina Chan; Jennifer Dong; Yan Qu; Meron Roose-Girma; Xiaodong Huang; Denise M Monack
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9771-6.
2007: Nobuhiko Kayagaki; Qui Phung; Salina Chan; Ruchir Chaudhari; Casey Quan; Karen M O'Rourke; Michael Eby; Eric Pietras; Genhong Cheng; J. Fernando Bazan; Zemin Zhang; David Arnott; Xiaodong Huang
DUBA: a deubiquitinase that regulates type I interferon production.
Science (New York, N.Y.) 2007;318(5856):1628-32.
2007: Eugene Varfolomeev; John W Blankenship; Sarah M Wayson; Anna V Fedorova; Nobuhiko Kayagaki; Parie Garg; Kerry Zobel; Jasmin Dynek; Linda O Elliott; Heidi J A Wallweber; John A Flygare; Wayne J Fairbrother; Kurt Deshayes; Xiaodong Huang; Domagoj Vucic
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
Cell 2007;131(4):669-81.
2005: Honglin Zhou; Denise M Monack; Nobuhiko Kayagaki; Ingrid E Wertz; Jianpin Yin; Beni Wolf; Xiaodong Huang
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.
The Journal of experimental medicine 2005;202(10):1327-32.
2005: Erika Cretney; Jonathan L McQualter; Nobuhiko Kayagaki; Hideo Yagita; Claude C A Bernard; Iqbal Grewal; Avi Ashkenazi; Mark J Smyth
TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice.
Immunology and cell biology 2005;83(5):511-9.
2004: Chinatsu Kasuga; Tomohiko Ebata; Nobuhiko Kayagaki; Hideo Yagita; Makoto Hishii; Hajime Arai; Kiyoshi Sato; Ko Okumura
Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.
Cancer science 2004;95(10):840-4.
2003: Yasuyuki Kirii; Tomomi Inoue; Kohichiro Yoshino; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura; Hiroaki Shibata; Yasuhiro Yoshikawa; Keiji Terao
Molecular cloning, functional characterization, and enzyme-linked immunosorbent assay of cynomolgus monkey Fas ligand.
Journal of immunological methods 2003;278(1-2):201-9.
2003: Kanako Uno; Takeshi Inukai; Nobuhiko Kayagaki; Kumiko Goi; Hiroki Sato; Atsushi Nemoto; Kazuya Takahashi; Keiko Kagami; Noriko Yamaguchi; Hideo Yagita; Ko Okumura; Toshiko Koyama-Okazaki; Toshio Suzuki; Kanji Sugita; Shinpei Nakazawa
TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.
Blood 2003;101(9):3658-67.
2002: Nobuhiko Kayagaki; Noriko Yamaguchi; Masaaki Abe; Sachiko Hirose; Toshikazu Shirai; Ko Okumura; Hideo Yagita
Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL).
Cellular immunology 2002;219(2):82-91.
2002: Nobuhiko Kayagaki; Minhong Yan; Dhaya Seshasayee; Hua Wang; Wyne Lee; Dorothy M French; Iqbal Grewal; Andrea G Cochran; Nathaniel C Gordon; JianPing Yin; Melissa A Starovasnik; Xiaodong Huang
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.
Immunity 2002;17(4):515-24.
2002: Lisa M Sedger; Moira Glaccum; JoAnn C L Schuh; Suzanne T Kanaly; Eilidh Williamson; Nobuhiko Kayagaki; Theordore Yun; Pam Smolak; Tiep Le; Ray Goodwin; Brian Gliniak
Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice.
European journal of immunology 2002;32(8):2246-54.
2002: Yoshinori Seko; Nobuhiko Kayagaki; Ken-ichiro Seino; Hideo Yagita; Ko Okumura; Ryozo Nagai
Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3.
Journal of the American College of Cardiology 2002;39(8):1399-403.
2002: Kazuyoshi Takeda; Mark J Smyth; Erika Cretney; Yoshihiro Hayakawa; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development.
The Journal of experimental medicine 2002;195(2):161-9.
2002: Masafumi Nakayama; Kazumi Ishidoh; Nobuhiko Kayagaki; Yuko Kojima; Noriko Yamaguchi; Hiroyasu Nakano; Eiki Kominami; Ko Okumura; Hideo Yagita
Multiple pathways of TWEAK-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):734-43.
2001: K Sato; S Hida; Hiroshi Takayanagi; Taeko Yokochi; Nobuhiko Kayagaki; K Takeda; Hideo Yagita; Ko Okumura; Naomi Tanaka; Tadatsugu Taniguchi; Kouetsu Ogasawara
Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta.
European journal of immunology 2001;31(11):3138-46.
2001: H Shinohara; Nobuhiko Kayagaki; H Yagita; Naoki Oyaizu; M Ohba; T Kuroki; Yoji Ikawa
A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells.
Biochemical and biophysical research communications 2001;284(5):1162-7.
2001: M J Smyth; Erika Cretney; K Takeda; Robert Wiltrout; Lisa M Sedger; Nobuhiko Kayagaki; H Yagita; K Okumura
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis.
The Journal of experimental medicine 2001;193(6):661-70.
2001: Kazuyoshi Takeda; Yoshihiro Hayakawa; Mark J Smyth; Nobuhiko Kayagaki; Noriko Yamaguchi; S Kakuta; Y Iwakura; Hideo Yagita; Ko Okumura
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells.
Nature medicine 2001;7(1):94-100.
2000: Masafumi Nakayama; Nobuhiko Kayagaki; Noriko Yamaguchi; Ko Okumura; Hideo Yagita
Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity.
The Journal of experimental medicine 2000;192(9):1373-80.
1999: Nobuhiko Kayagaki; Noriko Yamaguchi; Masafumi Nakayama; Kazuyoshi Takeda; Hisaya Akiba; H Tsutsui; H Okamura; K Nakanishi; Ko Okumura; Hideo Yagita
Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1906-13.
1999: K Hattori; Takao Hirano; C Ushiyama; Hiroaki Miyajima; N Yamakawa; S Ikeda; K Yoshino; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents acute graft-versus-host disease in mice after bone marrow transplantation.
Bone marrow transplantation 1999;23(12):1283-9.
1999: Nobuhiko Kayagaki; Noriko Yamaguchi; Masafumi Nakayama; H Eto; Ko Okumura; Hideo Yagita
Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
The Journal of experimental medicine 1999;189(9):1451-60.
1999: K Hattori; Takao Hirano; Hiroaki Miyajima; N Yamakawa; S Ikeda; K Yoshino; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation.
British journal of haematology 1999;105(1):303-12.
1999: Nobuhiko Kayagaki; Noriko Yamaguchi; Masafumi Nakayama; A Kawasaki; Hisaya Akiba; Ko Okumura; Hideo Yagita
Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2639-47.
1998: K Seino; Kazuhisa Iwabuchi; Nobuhiko Kayagaki; R Miyata; Isao Nagaoka; A Matsuzawa; K Fukao; Hideo Yagita; Ko Okumura
Chemotactic activity of soluble Fas ligand against phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4484-8.
1998: K Hattori; Takao Hirano; Hiroaki Miyajima; N Yamakawa; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologies.
Blood 1998;91(11):4051-5.
1997: Kenichiro Seino; Nobuhiko Kayagaki; N Tsukada; K Fukao; Hideo Yagita; Ko Okumura
Transplantation of CD95 ligand-expressing grafts: influence of transplantation site and difficulty in protecting allo- and xenografts.
Transplantation 1997;64(7):1050-4.
1997: Naoki Oyaizu; Nobuhiko Kayagaki; Hideo Yagita; Savita Pahwa; Yoji Ikawa
Requirement of cell-cell contact in the induction of Jurkat T cell apoptosis: the membrane-anchored but not soluble form of FasL can trigger anti-CD3-induced apoptosis in Jurkat T cells.
Biochemical and biophysical research communications 1997;238(2):670-5.
1997: K Hattori; Takao Hirano; C Ushiyama; Hiroaki Miyajima; N Yamakawa; T Ebata; Y Wada; S Ikeda; K Yoshino; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice.
Blood 1997;90(2):542-8.
1997: Naoki Oyaizu; Y Adachi; F Hashimoto; Thomas W McCloskey; N Hosaka; Nobuhiko Kayagaki; H Yagita; Savita Pahwa
Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2456-63.
1997: Kenichiro Seino; Nobuhiko Kayagaki; K Fukao; Ko Okumura; Hideo Yagita
Rejection of Fas ligand-expressing grafts.
Transplantation proceedings 1997;29(1-2):1092-3.
1997: K Seino; Nobuhiko Kayagaki; Ko Okumura; Hideo Yagita
Antitumor effect of locally produced CD95 ligand.
Nature medicine 1997;3(2):165-70.
1996: K Seino; Nobuhiko Kayagaki; H Bashuda; K Okumura; Hideo Yagita
Contribution of Fas ligand to cardiac allograft rejection.
International immunology 1996;8(9):1347-54.
1996: Yoshiaki Tokano; S Miyake; Nobuhiko Kayagaki; Kazuhisa Nozawa; S Morimoto; Miyuki Azuma; Hideo Yagita; Yoshinari Takasaki; K Okumura; Hiroshi Hashimoto
Soluble Fas molecule in the serum of patients with systemic lupus erythematosus.
Journal of clinical immunology 1996;16(5):261-5.
1996: Nobuhiko Kayagaki; H Yagita
[Metalloproteinase-mediated release of human fas ligand].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(7):1747-52.
1996: H Yagita; K Seino; Nobuhiko Kayagaki; K Okumura
CD95 ligand in graft rejection.
Nature 1996;379(6567):682.
1995: Nobuhiko Kayagaki; A Kawasaki; T Ebata; H Ohmoto; S Ikeda; S Inoue; K Yoshino; K Okumura; Hideo Yagita
Metalloproteinase-mediated release of human Fas ligand.
The Journal of experimental medicine 1995;182(6):1777-83.