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Frank Baglia

Research Profile

Chemicals & Drugs

Anatomy

Blood Platelets

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Physiology

Platelet Activation

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
Frank A Baglia; Corie N Shrimpton; Jonas Emsley; Kouki Kitagawa; Zaverio M Ruggeri; José A López; Peter N Walsh
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet.
Frank A Baglia; David Gailani; José A López; Peter N Walsh
Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI.
Thomas H Yun; Frank A Baglia; Timothy Myles; Duraiswamy Navaneetham; José A López; Peter N Walsh; Lawrence L K Leung
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively.

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All Publications

2004: Frank A Baglia; Corie N Shrimpton; Jonas Emsley; Kouki Kitagawa; Zaverio M Ruggeri; José A López; Peter N Walsh
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet.
The Journal of biological chemistry 2004;279(47):49323-9.
2004: Frank A Baglia; David Gailani; José A López; Peter N Walsh
Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI.
The Journal of biological chemistry 2004;279(44):45470-6.
2003: Thomas H Yun; Frank A Baglia; Timothy Myles; Duraiswamy Navaneetham; José A López; Peter N Walsh; Lawrence L K Leung
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively.
The Journal of biological chemistry 2003;278(48):48112-9.
2003: Frank A Baglia; Corie N Shrimpton; José A López; Peter N Walsh
The glycoprotein Ib-IX-V complex mediates localization of factor XI to lipid rafts on the platelet membrane.
The Journal of biological chemistry 2003;278(24):21744-50.
2002: Frank A Baglia; Karen O Badellino; Chester Q Li; Jose A Lopez; Peter N Walsh
Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin.
The Journal of biological chemistry 2002;277(3):1662-8.
2001: Mao-Fu Sun; Frank A Baglia; D Ho; Danko Martincic; R E Ware; Peter N Walsh; David Gailani
Defective binding of factor XI-N248 to activated human platelets.
Blood 2001;98(1):125-9.
2000: Frank A Baglia; Karen O Badellino; DH Ho; VR Dasari; Peter N Walsh
A binding site for the kringle II domain of prothrombin in the apple 1 domain of factor XI.
The Journal of biological chemistry 2000;275(41):31954-62.
2000: DH Ho; Karen O Badellino; Frank A Baglia; Mao-Fu Sun; M M Zhao; David Gailani; Peter N Walsh
The role of high molecular weight kininogen and prothrombin as cofactors in the binding of factor XI A3 domain to the platelet surface.
The Journal of biological chemistry 2000;275(33):25139-45.
2000: Frank A Baglia; Peter N Walsh
Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa.
The Journal of biological chemistry 2000;275(27):20514-9.
2000: DH Ho; Frank A Baglia; Peter N Walsh
Factor XI binding to activated platelets is mediated by residues R(250), K(255), F(260), and Q(263) within the apple 3 domain.
Biochemistry 2000;39(2):316-23.
1998: DH Ho; Karen O Badellino; Frank A Baglia; Peter N Walsh
A binding site for heparin in the apple 3 domain of factor XI.
The Journal of biological chemistry 1998;273(26):16382-90.
1998: C J Hu; Frank A Baglia; D C Mills; B A Konkle; Peter N Walsh
Tissue-specific expression of functional platelet factor XI is independent of plasma factor XI expression.
Blood 1998;91(10):3800-7.
1998: Frank A Baglia; Peter N Walsh
Prothrombin is a cofactor for the binding of factor XI to the platelet surface and for platelet-mediated factor XI activation by thrombin.
Biochemistry 1998;37(8):2271-81.
1996: Frank A Baglia; Peter N Walsh
A binding site for thrombin in the apple 1 domain of factor XI.
The Journal of biological chemistry 1996;271(7):3652-8.
1995: Frank A Baglia; F S Seaman; Peter N Walsh
The Apple 1 and Apple 4 domains of factor XI act synergistically to promote the surface-mediated activation of factor XI by factor XIIa.
Blood 1995;85(8):2078-83.
1995: Frank A Baglia; B A Jameson; Peter N Walsh
Identification and characterization of a binding site for platelets in the Apple 3 domain of coagulation factor XI.
The Journal of biological chemistry 1995;270(12):6734-40.
1994: F S Seaman; Frank A Baglia; J A Gurr; B A Jameson; Peter N Walsh
Binding of high-molecular-mass kininogen to the Apple 1 domain of factor XI is mediated in part by Val64 and Ile77.
The Biochemical journal 1994;304 ( Pt 3)():715-21.
1993: Peter N Walsh; Frank A Baglia; B A Jameson
Factor XI and platelets: activation and regulation.
Thrombosis and haemostasis 1993;70(1):75-9.
1993: Frank A Baglia; B A Jameson; Peter N Walsh
Identification and characterization of a binding site for factor XIIa in the Apple 4 domain of coagulation factor XI.
The Journal of biological chemistry 1993;268(6):3838-44.
1993: Peter N Walsh; Frank A Baglia; B A Jameson
Factor XI: structure-function relationships utilizing monoclonal antibodies protein modification, computational chemistry, and rational synthetic peptide design.
Methods in enzymology 1993;222():65-96.
1992: Frank A Baglia; B A Jameson; Peter N Walsh
Fine mapping of the high molecular weight kininogen binding site on blood coagulation factor XI through the use of rationally designed synthetic analogs.
The Journal of biological chemistry 1992;267(6):4247-52.
1991: Frank A Baglia; B A Jameson; Peter N Walsh
Identification and chemical synthesis of a substrate-binding site for factor IX on coagulation factor XIa.
The Journal of biological chemistry 1991;266(35):24190-7.
1990: Frank A Baglia; B A Jameson; Peter N Walsh
Localization of the high molecular weight kininogen binding site in the heavy chain of human factor XI to amino acids phenylalanine 56 through serine 86.
The Journal of biological chemistry 1990;265(7):4149-54.
1989: Frank A Baglia; D Sinha; Peter N Walsh
Functional domains in the heavy-chain region of factor XI: a high molecular weight kininogen-binding site and a substrate-binding site for factor IX.
Blood 1989;74(1):244-51.
1988: R A De La Cadena; Frank A Baglia; C A Johnson; R E Wenk; R Amernick; Peter N Walsh; Robert W Colman
Naturally occurring human antibodies against two distinct functional domains in the heavy chain of FXI/FXIa.
Blood 1988;72(5):1748-54.