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Lyndal Kearney

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Frederik W van Delft; Jan Zuna; Kristina Anderson; Caroline Bateman; Sue Colman; Cornelia Eckert; Anthony Ford; Sharon W Horsley; Lyndal Kearney; Helena Kempski; Vaskar Saha; Mel Greaves
Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia.
Kristina Anderson; Christoph Lutz; Frederik W van Delft; Caroline M Bateman; Yanping Guo; Susan M Colman; Helena Kempski; Anthony V Moorman; Ian Titley; John Swansbury; Lyndal Kearney; Tariq Enver; Mel Greaves
Genetic variegation of clonal architecture and propagating cells in leukaemia.
Caroline M Bateman; Susan M Colman; Tracy Chaplin; Bryan D Young; Tim O Eden; Manoo Bhakta; Eric J Gratias; Elisabeth R van Wering; Giovanni Cazzaniga; Christine J Harrison; Richard Hain; Philip Ancliff; Anthony M Ford; Lyndal Kearney; Mel Greaves
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.

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All Publications

2011: Frederik W van Delft; Jan Zuna; Kristina Anderson; Caroline Bateman; Sue Colman; Cornelia Eckert; Anthony Ford; Sharon W Horsley; Lyndal Kearney; Helena Kempski; Vaskar Saha; Mel Greaves
Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia.
Blood 2011;117(23):6247-54.
2011: Kristina Anderson; Christoph Lutz; Frederik W van Delft; Caroline M Bateman; Yanping Guo; Susan M Colman; Helena Kempski; Anthony V Moorman; Ian Titley; John Swansbury; Lyndal Kearney; Tariq Enver; Mel Greaves
Genetic variegation of clonal architecture and propagating cells in leukaemia.
Nature 2011;469(7330):356-61.
2010: Caroline M Bateman; Susan M Colman; Tracy Chaplin; Bryan D Young; Tim O Eden; Manoo Bhakta; Eric J Gratias; Elisabeth R van Wering; Giovanni Cazzaniga; Christine J Harrison; Richard Hain; Philip Ancliff; Anthony M Ford; Lyndal Kearney; Mel Greaves
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.
Blood 2010;115(17):3553-8.
2009: Lyndal Kearney; David Gonzalez De Castro; Jenny Yeung; Julia Procter; Sharon W Horsley; Minenori Eguchi-Ishimae; Caroline M Bateman; Kristina Anderson; Tracy Chaplin; Bryan D Young; Christine J Harrison; Helena Kempski; Chi Wai E So; Anthony M Ford; Mel Greaves
Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.
Blood 2009;113(3):646-8.
2009: Lyndal Kearney; Sue Colman
Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research.
Methods in molecular biology (Clifton, N.J.) 2009;538():57-70.
2008: Sharon W Horsley; Susan Colman; Mark McKinley; Caroline M Bateman; Meriel Jenney; Tracy Chaplin; Bryan D Young; Mel Greaves; Lyndal Kearney
Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia.
Genes, chromosomes & cancer 2008;47(4):333-40.
2006: Sharon W Horsley; Alan Mackay; Marjan Iravani; Kerry Fenwick; Haukur Valgeirsson; Tim Dexter; Alan Ashworth; Lyndal Kearney
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes, chromosomes & cancer 2006;45(6):554-64.
2006: Lyndal Kearney
Multiplex-FISH (M-FISH): technique, developments and applications.
Cytogenetic and genome research 2006;114(3-4):189-98.
2005: Lyndal Kearney; Sharon W Horsley
Molecular cytogenetics in haematological malignancy: current technology and future prospects.
Chromosoma 2005;114(4):286-94.
2004: Alicja M Gruszka-Westwood; Sharon W Horsley; Angel Martinez-Ramirez; Christine J Harrison; Helena Kempski; Anthony V Moorman; Fiona M Ross; Michael Griffiths; Mel F Greaves; Lyndal Kearney
Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia.
Genes, chromosomes & cancer 2004;41(3):191-202.
2004: Christine J Harrison; Helena Kempski; David W Hammond; Lyndal Kearney
Molecular cytogenetics in childhood leukemia.
Methods in molecular medicine 2004;91():123-37.
2003: Sabrina Tosi; Jim Hughes; Stephen W Scherer; Kazuhiko Nakabayashi; Jochen Harbott; Oskar A Haas; Giovanni Cazzaniga; Andrea Biondi; Helena Kempski; Lyndal Kearney
Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia.
Genes, chromosomes & cancer 2003;38(2):191-200.
2003: Helena Kempski; Karen A Mensa-Bonsu; Lyndal Kearney; G Reza Jalali; Ian Hann; Mohammed Khurshid; Mel Greaves
Prenatal chromosomal diversification of leukemia in monozygotic twins.
Genes, chromosomes & cancer 2003;37(4):406-11.
2002: Susanne Popp; Birgit Schulze; Martin Granzow; Monika Keller; Heidi Holtgreve-Grez; Brigitte Schoell; Michaela Brough; Hans-Dieter Hager; Gholamali Tariverdian; Jill Brown; Lyndal Kearney; Anna Jauch
Study of 30 patients with unexplained developmental delay and dysmorphic features or congenital abnormalities using conventional cytogenetics and multiplex FISH telomere (M-TEL) integrity assay.
Human genetics 2002;111(1):31-9.
2002: Jacqueline Boultwood; Carrie Fidler; Amanda J Strickson; Fiona Watkins; Susana Gama; Lyndal Kearney; Sabrina Tosi; Arek Kasprzyk; Jan-Fang Cheng; Rina J Jaju; james wainscoat
Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome.
Blood 2002;99(12):4638-41.
2002: Jill Brown; mays jawad; Stephen R F Twigg; Kaan Saracoglu; Axel Sauerbrey; Angela E Thomas; Roland Eils; Jochen Harbott; Lyndal Kearney
A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay.
Blood 2002;99(7):2526-31.
2002: Lyndal Kearney; Sabrina Tosi; Rina J Jaju
Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridization.
Methods in molecular medicine 2002;68():7-27.
2001: Christine Fauth; H Zhang; S Harabacz; Jill Brown; Kaan Saracoglu; Gaby Lederer; O Rittinger; Imma Rost; Roland Eils; Lyndal Kearney; Michael R Speicher
A new strategy for the detection of subtelomeric rearrangements.
Human genetics 2001;109(6):576-83.
2001: Lyndal Kearney
Molecular cytogenetics.
Best practice & research. Clinical haematology 2001;14(3):645-69.
2001: Rina J Jaju; Carrie Fidler; Oskar A Haas; Amanda J Strickson; Fiona Watkins; K Clark; Nicholas C P Cross; Jan-Fang Cheng; P D Aplan; Lyndal Kearney; Jacqueline Boultwood; james wainscoat
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.
Blood 2001;98(4):1264-7.
2001: Giovanni Cazzaniga; M Daniotti; Sabrina Tosi; Giovanni Giudici; Alessandra Aloisi; Enrico Pogliani; Lyndal Kearney; Andrea Biondi
The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case.
Cancer research 2001;61(12):4666-70.
2001: Kaan Saracoglu; Jill Brown; Lyndal Kearney; Sabine Uhrig; J Azofeifa; Christine Fauth; Michael R Speicher; Roland Eils
New concepts to improve resolution and sensitivity of molecular cytogenetic diagnostics by multicolor fluorescence in situ hybridization.
Cytometry 2001;44(1):7-15.
2001: Jill Brown; Kaan Saracoglu; Sabine Uhrig; M R Speicher; Roland Eils; Lyndal Kearney
Subtelomeric chromosome rearrangements are detected using an innovative 12-color FISH assay (M-TEL).
Nature medicine 2001;7(4):497-501.
2001: Sharon W Horsley; Rachael J Daniels; Eduardo Anguita; H A Raynham; JF Peden; Ana Villegas; M A Vickers; S Green; J S Waye; D H Chui; Helena Ayyub; A B MacCarthy; Veronica Buckle; Richard J Gibbons; Lyndal Kearney; Douglas R Higgs
Monosomy for the most telomeric, gene-rich region of the short arm of human chromosome 16 causes minimal phenotypic effects.
European journal of human genetics : EJHG 2001;9(3):217-25.
2001: Rachael J Daniels; JF Peden; C Lloyd; Sharon W Horsley; Kevin Clark; Cristina Tufarelli; Lyndal Kearney; Veronica Buckle; N A Doggett; Jonathan Flint; Douglas R Higgs
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
Human molecular genetics 2001;10(4):339-52.
2001: Caroline Mackie Ogilvie; R H Harrison; Sharon W Horsley; Shirley V Hodgson; Lyndal Kearney
A mitotically stable marker chromosome negative for whole chromosome libraries, centromere probes and chromosome specific telomere regions: a novel class of supernumerary marker chromosome?
Cytogenetics and cell genetics 2001;92(1-2):69-73.
2000: Jill Brown; Sharon W Horsley; C Jung; Kaan Saracoglu; B Janssen; Michaela Brough; M Daschner; B Beedgen; G Kerkhoffs; Roland Eils; Peter C Harris; Anna Jauch; Lyndal Kearney
Identification of a subtle t(16;19)(p13.3;p13.3) in an infant with multiple congenital abnormalities using a 12-colour multiplex FISH telomere assay, M-TEL.
European journal of human genetics : EJHG 2000;8(12):903-10.
2000: Sabrina Tosi; Jochen Harbott; Andrea Teigler-Schlegel; Oskar A Haas; H Pirc-Danoewinata; Christine J Harrison; Andrea Biondi; Giovanni Cazzaniga; Helena Kempski; Stephen W Scherer; Lyndal Kearney
t(7;12)(q36;p13), a new recurrent translocation involving ETV6 in infant leukemia.
Genes, chromosomes & cancer 2000;29(4):325-32.
2000: Rina J Jaju; Margaret Jones; Jacqueline Boultwood; S Kelly; David Y Mason; james wainscoat; Lyndal Kearney
Combined immunophenotyping and FISH identifies the involvement of B-cells in 5q- syndrome.
Genes, chromosomes & cancer 2000;29(3):276-80.
2000: Debra M Lillington; Rina J Jaju; AG Shankar; Michael J Neat; Lyndal Kearney; Bryan D Young; Vaskar Saha
Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia.
British journal of haematology 2000;110(3):547-51.
2000: Laurence Game; James Paul Close; P Stephens; J Mitchell; Steve Best; Jacques Rochette; C Louis-dit-Sully; J Riley; Chee Gee See; P Sanseau; Lyndal Kearney; G Bethel; Sean Humphray; Ian Dunham; Andrew Mungall; Swee Lay Thein
An integrated map of human 6q22.3-q24 including a 3-Mb high-resolution BAC/PAC contig encompassing a QTL for fetal hemoglobin.
Genomics 2000;64(3):264-76.
2000: Christine J Harrison; B Gibbons; F Yang; T Butler; Kan L Cheung; Lyndal Kearney; L Dirscherl; P Bray-Ward; M Gregson; M Ferguson-Smith
Multiplex fluorescence in situ hybridization and cross species color banding of a case of chronic myeloid leukemia in blastic crisis with a complex Philadelphia translocation.
Cancer genetics and cytogenetics 2000;116(2):105-10.
1999: Giovanni Cazzaniga; Sabrina Tosi; Alessandra Aloisi; Giovanni Giudici; M Daniotti; Pietro Pioltelli; Lyndal Kearney; Andrea Biondi
The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts.
Blood 1999;94(12):4370-3.
1999: Samantha J L Knight; Regina Regan; A Nicod; Sharon W Horsley; Lyndal Kearney; TF Homfray; Robin M Winter; Patrick Bolton; Jonathan Flint
Subtle chromosomal rearrangements in children with unexplained mental retardation.
Lancet 1999;354(9191):1676-81.
1999: Sabrina Tosi; Stephen W Scherer; Giovanni Giudici; B Czepulkowski; Andrea Biondi; Lyndal Kearney
Delineation of multiple deleted regions in 7q in myeloid disorders.
Genes, chromosomes & cancer 1999;25(4):384-92.
1999: Rina J Jaju; Oskar A Haas; Michael J Neat; Jochen Harbott; Vaskar Saha; Jacqueline Boultwood; J M Brown; H Pirc-Danoewinata; B W Krings; U Müller; Stephan W Morris; james wainscoat; Lyndal Kearney
A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG)
Blood 1999;94(2):773-80.
1999: Sabrina Tosi; Giovanni Giudici; A Rambaldi; Stephen W Scherer; P Bray-Ward; L Dirscherl; Andrea Biondi; Lyndal Kearney
Characterization of the human myeloid leukemia-derived cell line GF-D8 by multiplex fluorescence in situ hybridization, subtelomeric probes, and comparative genomic hybridization.
Genes, chromosomes & cancer 1999;24(3):213-21.
1999: Lyndal Kearney
The impact of the new fish technologies on the cytogenetics of haematological malignancies.
British journal of haematology 1999;104(4):648-58.
1998: David Johnson; Sharon W Horsley; DM Moloney; Michael Oldridge; Stephen R F Twigg; S Walsh; M Barrow; P R Njølstad; Juergen Kunz; G J Ashworth; Steven A Wall; Lyndal Kearney; Andrew O M Wilkie
A comprehensive screen for TWIST mutations in patients with craniosynostosis identifies a new microdeletion syndrome of chromosome band 7p21.1.
American journal of human genetics 1998;63(5):1282-93.
1998: Sharon W Horsley; Samantha J L Knight; J Nixon; SM Huson; M Fitchett; R A Boone; D Hilton-Jones; Jonathan Flint; Lyndal Kearney
Del(18p) shown to be a cryptic translocation using a multiprobe FISH assay for subtelomeric chromosome rearrangements.
Journal of medical genetics 1998;35(9):722-6.
1998: Rina J Jaju; Jacqueline Boultwood; F J Oliver; M Kostrzewa; Carrie Fidler; N Parker; J D McPherson; Stephan W Morris; U Müller; james wainscoat; Lyndal Kearney
Molecular cytogenetic delineation of the critical deleted region in the 5q- syndrome.
Genes, chromosomes & cancer 1998;22(3):251-6.
1998: Sabrina Tosi; Giovanni Giudici; G Mosna; Jochen Harbott; G Specchia; G Grosveld; Enrica Privitera; Lyndal Kearney; Andrea Biondi; Giovanni Cazzaniga
Identification of new partner chromosomes involved in fusions with the ETV6 (TEL) gene in hematologic malignancies.
Genes, chromosomes & cancer 1998;21(3):223-9.
1998: JD Shearman; Jennifer J Pointon; Alison T Merryweather-Clarke; C Stone; Sharon W Horsley; Lyndal Kearney; WM Rosenberg; Kathryn J H Robson
Rapid mapping of markers applying vectorette technology to YAC fragmentation allows easy assembly of a high-density STS bacterial clone contig spanning the markers D6S1260-D6S1918.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(3):220-5.
1997: Thuan Dinh Bui; David Beier; M Jonssen; Kath Smith; S M Dorrington; LG Kaklamanis; Lyndal Kearney; Regina Regan; D J Sussman; Adrian L Harris
cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.
Biochemical and biophysical research communications 1997;239(2):510-6.
1997: Sabrina Tosi; G Mosna; Giovanni Cazzaniga; Giovanni Giudici; Lyndal Kearney; Andrea Biondi; Enrica Privitera
Unbalanced t(3;12) in a case of juvenile myelomonocytic leukemia (JMML) results in partial trisomy of 3q as defined by FISH.
Leukemia 1997;11(9):1465-8.
1997: Samantha J L Knight; Sharon W Horsley; Regina Regan; N M Lawrie; E J Maher; D L Cardy; Jonathan Flint; Lyndal Kearney
Development and clinical application of an innovative fluorescence in situ hybridization technique which detects submicroscopic rearrangements involving telomeres.
European journal of human genetics : EJHG 1997;5(1):1-8.
1996: Jonathan Flint; Jacques Rochette; Charles Craddock; Catherine Dodé; B Vignes; Sharon W Horsley; Lyndal Kearney; V J Buckle; H Ayyub; Douglas R Higgs
Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements.
Human molecular genetics 1996;5(8):1163-9.
1996: S Tosi; Jochen Harbott; O A Haas; A Douglas; D M Hughes; F M Ross; Andrea Biondi; Stephen W Scherer; Lyndal Kearney
Classification of deletions and identification of cryptic translocations involving 7q by fluorescence in situ hybridization (FISH).
Leukemia 1996;10(4):644-9.
1995: Richard J Gibbons; Louise A Brueton; V J Buckle; J Burn; Jill Clayton-Smith; B C Davison; R J Gardner; TF Homfray; Lyndal Kearney; HM Kingston
Clinical and hematologic aspects of the X-linked alpha-thalassemia/mental retardation syndrome (ATR-X).
American journal of medical genetics 1995;55(3):288-99.
1995: Y Hashim; Jiannis Ragoussis; Lyndal Kearney; S Tosi; Alexander Kai-Lik So
Physical mapping of the human T-cell receptor beta gene complex, using yeast artificial chromosomes.
Immunogenetics 1995;41(6):337-42.
1994: V J Buckle; Lyndal Kearney
New methods in cytogenetics.
Current opinion in genetics & development 1994;4(3):374-82.
1993: V J Buckle; Lyndal Kearney
Untwirling dirvish.
Nature genetics 1993;5(1):4-5.