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Mark Kearney

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TOP 3
Richard M Cubbon; Ben N Mercer; Anshuman Sengupta; Mark T Kearney
Importance of insulin resistance to vascular repair and regeneration.
Mark T Kearney
Changing the Way We Think About Endothelial Cell Insulin Sensitivity, Nitric Oxide, and the Pathophysiology of Type 2 Diabetes: The FoxO Is Loose.
Eleanor M Scott; Ida Pernicova; Stephen G Gilbey; John P Greenwood; Mark T Kearney; Graham R Law; David A S G Mary
Sympathetic activation and vasoregulation in response to carbohydrate ingestion in patients with congestive heart failure.

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All Publications

2013: Richard M Cubbon; Ben N Mercer; Anshuman Sengupta; Mark T Kearney
Importance of insulin resistance to vascular repair and regeneration.
Free radical biology & medicine 2013;60():246-63.
2013: Mark T Kearney
Changing the Way We Think About Endothelial Cell Insulin Sensitivity, Nitric Oxide, and the Pathophysiology of Type 2 Diabetes: The FoxO Is Loose.
Diabetes 2013;62(5):1386-8.
2013: Eleanor M Scott; Ida Pernicova; Stephen G Gilbey; John P Greenwood; Mark T Kearney; Graham R Law; David A S G Mary
Sympathetic activation and vasoregulation in response to carbohydrate ingestion in patients with congestive heart failure.
The Canadian journal of cardiology 2013;29(2):236-42.
2012: Helen Imrie; Afroze Abbas; David J Beech; Keith M Channon; Richard M Cubbon; T Simon Futers; Matthew Gage; Stacey Galloway; V Kate Gatenby; Peter J Grant; Sheik Taqweer Rashid; Anna Skromna; Jessica Smith; Piruthivi Sukumar; Hema Viswambharan; Stephen B Wheatcroft; Shouhong Xuan; Nadira Yuldasheva; Mark T Kearney
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Diabetes 2012;61(9):2359-68.
2012: Piruthivi Sukumar; Lesley A Wilson; Justin F-X Ainscough; Mark T Kearney; Jing Li; Jonathan D Lippiat; David O'Regan; Karen E Porter; Alicia Sedo; David J Beech
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.
Circulation research 2012;111(2):191-200.
2012: B N Mercer; S Morais; Richard M Cubbon; Mark T Kearney
Diabetes mellitus and the heart.
International journal of clinical practice 2012;66(7):640-7.
2012: Richard M Cubbon; Noman Ali; Anshu Sengupta; Mark T Kearney
Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus.
Current vascular pharmacology 2012;10(3):271-84.
2012: Adil Rajwani; Jaswinder K Sethi; Ajay M Shah; Jessica Smith; Piruthivi Sukumar; antonio vidal-puig; Hema Viswambharan; Afroze Abbas; Amir Aziz; Richard M Cubbon; Edward R Duncan; Vivienne Ezzat; Matthew Gage; Peter J Grant; Helen Imrie; Matthew B Kahn; Mark T Kearney; Karen E Porter; Shouhong Xuan; Nadira Y Yuldasheva; Stephen B Wheatcroft
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis.
Diabetes 2012;61(4):915-24.
2012: Alexander F Bruns; Paul Frankel; Gareth J Howell; Mark T Kearney; Antony M Latham; Caroline Pellet-Many; Sam L Stephen; Stephen B Wheatcroft; Nadira Yuldasheva; Ian C Zachary; Leyuan Bao; Sreenivasan Ponnambalam
A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.
PloS one 2012;7(11):e48539.
2011: Afroze Abbas; David J Beech; Keith M Channon; Richard M Cubbon; Matthew Gage; Stacey Galloway; Peter J Grant; Helen Imrie; Matthew Kahn; Adil Rajwani; Jessica Smith; Piruthivi Sukumar; Hema Viswambharan; Stephen B Wheatcroft; Shouhong Xuan; Nadira Yuldeshava; Mark T Kearney
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.
Diabetes 2011;60(8):2169-78.
2011: Richard M Cubbon; Anthony C Fisher; Keith A A Fox; Chris Gale; David Groves; Matthew B Kahn; Lorraine C Kearney; SJ Lindsay; Jim Nolan; Adil Rajwani; Robert J Sapsford; Clyde Schechter; Ajay M Shah; Stephen B Wheatcroft; Klaus K A Witte; Azfar G Zaman; Wazir Baig; Pauline Barlow; Philip D Batin; W Paul Brooksby; Jon A Byrne; Mark T Kearney
Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras.
Circulation. Heart failure 2011;4(4):396-403.
2011: Jing Li; Richard M Cubbon; Lesley A Wilson; Mohamed S Amer; Lynn McKeown; Bing Hou; Yasser Majeed; Sarka Tumova; Victoria A L Seymour; Hilary Taylor; Martin Stacey; David O'Regan; Richard Foster; Karen E Porter; Mark T Kearney; David J Beech
Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.
Circulation research 2011;108(10):1190-8.
2011: Matthew B Kahn; Nadira Y Yuldasheva; Richard M Cubbon; Jessica Smith; Sheikh T Rashid; Hema Viswambharan; Helen Imrie; Afroze Abbas; Adil Rajwani; Amir Aziz; Vivek Baliga; Piruthivi Sukumar; Matthew Gage; Mark T Kearney; Stephen B Wheatcroft
Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration.
Diabetes 2011;60(4):1295-303.
2010: Victoria K Gatenby; Mark T Kearney
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease.
Expert opinion on therapeutic targets 2010;14(12):1333-42.
2010: Jacqueline Naylor; Jing Li; Carol J Milligan; Fanning Zeng; Piruthivi Sukumar; Bing Hou; Alicia Sedo; Nadira Yuldasheva; Yasser Majeed; Dhananjay Beri; Shan Jiang; Victoria A L Seymour; Lynn McKeown; Bhaskar Kumar; Christian Harteneck; David O'Regan; Stephen B Wheatcroft; Mark T Kearney; Clare Jones; Karen E Porter; David J Beech
Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.
Circulation research 2010;106(9):1507-15.
2010: Richard M Cubbon; Scott R Murgatroyd; Carrie Ferguson; T Scott Bowen; Mark Rakobowchuk; Vivek Baliga; Daniel T Cannon; Adil Rajwani; Afroze Abbas; Matthew Kahn; Karen M Birch; Karen E Porter; Stephen B Wheatcroft; Harry B Rossiter; Mark T Kearney
Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):878-84.
2009: Helen Imrie; Afroze Abbas; Hema Viswambharan; Adil Rajwani; Richard M Cubbon; Matthew Gage; Matthew Kahn; Vivienne A Ezzat; Edward R Duncan; Peter J Grant; Ramzi Ajjan; Stephen B Wheatcroft; Mark T Kearney
Vascular insulin-like growth factor-I resistance and diet-induced obesity.
Endocrinology 2009;150(10):4575-82.
2009: Stephen B Wheatcroft; Mark T Kearney
IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis.
Trends in endocrinology and metabolism: TEM 2009;20(4):153-62.
2009: Ramzi A Ajjan; Kristina Standeven; M Khanbhai; Fladia Phoenix; K C Gersh; John W Weisel; Mark T Kearney; Robert A S Ariëns; Peter J Grant
Effects of aspirin on clot structure and fibrinolysis using a novel in vitro cellular system.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(5):712-7.
2008: Afroze Abbas; Peter J Grant; Mark T Kearney
Role of IGF-1 in glucose regulation and cardiovascular disease.
Expert review of cardiovascular therapy 2008;6(8):1135-49.
2008: Rafal Dworakowski; Simon Walker; Aziz Momin; Jatin Desai; Ahmed El-Gamel; Olaf Wendler; Mark T Kearney; Ajay M Shah
Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure.
Journal of the American College of Cardiology 2008;51(14):1349-56.
2008: Vivienne A Ezzat; Edward R Duncan; Stephen B Wheatcroft; Mark T Kearney
The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease.
Diabetes, obesity & metabolism 2008;10(3):198-211.
2008: Narbeh Melikian; Philip J Chowienczyk; Philip A MacCarthy; Ian L Williams; Stephen B Wheatcroft; Roy Sherwood; Christopher Gale; Ajay M Shah; Mark T Kearney
Determinants of endothelial function in asymptomatic subjects with and without the metabolic syndrome.
Atherosclerosis 2008;197(1):375-82.
2008: Richard M Cubbon; Chris Gale; Adil Rajwani; Afroze Abbas; Christine Morrell; Raj Das; Julian Barth; Peter J Grant; Mark T Kearney; Alistair Hall
Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome.
Diabetes care 2008;31(2):363-5.
2008: Richard M Cubbon; Afroze Abbas; Stephen B Wheatcroft; Niamh Kilcullen; Raj Das; Christine Morrell; Julian Barth; Mark T Kearney; Alistair Hall
Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event.
PloS one 2008;3(10):e3483.
2008: Mark T Kearney; Edward R Duncan; Mathew Kahn; Stephen B Wheatcroft
Insulin resistance and endothelial cell dysfunction: studies in mammalian models.
Experimental physiology 2008;93(1):158-63.
2007: Edward R Duncan; Simon J Walker; Vivienne A Ezzat; Stephen B Wheatcroft; Jian-Mei Li; Ajay M Shah; Mark T Kearney
Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1311-9.
2007: Richard M Cubbon; Adil Rajwani; Afroze Abbas; Chris Gale; Peter J Grant; Stephen B Wheatcroft; Julian Barth; Mark T Kearney; Alistair Hall
Hyperglycaemia, in relation to sex, and mortality after acute coronary syndrome.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2007;14(5):666-71.
2007: Richard M Cubbon; Chris Gale; Peter J Grant; Alistair Hall; Mark T Kearney
Lower rates of heart failure and death in acute coronary syndromes.
JAMA : the journal of the American Medical Association 2007;298(9):969; author reply 970-1.
2007: Narbeh Melikian; Mark T Kearney; Martyn R Thomas; Bernard De Bruyne; Ajay M Shah; Philip A MacCarthy
A simple thermodilution technique to assess coronary endothelium-dependent microvascular function in humans: validation and comparison with coronary flow reserve.
European heart journal 2007;28(18):2188-94.
2007: Aziz U Momin; Narbeh Melikian; Stephen B Wheatcroft; David J Grieve; Lindsay C John; Ahmed El-Gamel; Michael T Marrinan; Jatin B Desai; Catherine Driver; Roy Sherwood; Ajay M Shah; Mark T Kearney
The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery.
The Journal of thoracic and cardiovascular surgery 2007;134(2):335-41.
2007: Narbeh Melikian; Stephen B Wheatcroft; Okechukwu Samuel Ogah; Cliona Murphy; Philip J Chowienczyk; Anthony S Wierzbicki; Thomas Sanders; Benyu Jiang; Edward R Duncan; Ajay M Shah; Mark T Kearney
Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men.
Hypertension 2007;49(4):873-7.
2007: Cliona Murphy; Gajen S Kanaganayagam; Benyu Jiang; Philip J Chowienczyk; Rainer Zbinden; Mrinal Saha; Salman Rahman; Ajay M Shah; Michael S Marber; Mark T Kearney
Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):936-42.
2007: Anthony J Balmforth; Peter J Grant; Eleanor M Scott; Stephen B Wheatcroft; Mark T Kearney; Bart Staels; Nikolaus Marx
Inter-subject differences in constitutive expression levels of the clock gene in man.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(1):39-43.
2007: Richard M Cubbon; Stephen B Wheatcroft; Peter J Grant; Chris Gale; Julian Barth; Robert J Sapsford; Ramzi A Ajjan; Mark T Kearney; Alistair Hall
Temporal trends in mortality of patients with diabetes mellitus suffering acute myocardial infarction: a comparison of over 3000 patients between 1995 and 2003.
European heart journal 2007;28(5):540-5.
2007: Stephen B Wheatcroft; Mark T Kearney; Ajay M Shah; Vivienne A Ezzat; John R Miell; Michel Modo; Stephen C R Williams; Will P Cawthorn; Gema Medina-Gomez; Antonio Vidal-Puig; Jaswinder Sethi; Paul A Crossey
IGF-binding protein-2 protects against the development of obesity and insulin resistance.
Diabetes 2007;56(2):285-94.
2007: Natalia M Arzeno; Mark T Kearney; Dwain L Eckberg; James Nolan; Chi-Sang Poon
Heart rate chaos as a mortality predictor in mild to moderate heart failure.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2007;2007():5051-4.
2006: Aziz U Momin; Narbeh Melikian; Ajay M Shah; David J Grieve; Stephen B Wheatcroft; Lindsay John; Ahmed El-Gamel; Jatin B Desai; Toby Nelson; Catherine Driver; Roy A Sherwood; Mark T Kearney
Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: Evidence for tissue specificity of leptin resistance.
European heart journal 2006;27(19):2294-9.
2006: Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; Ameet Patel; Roy A Sherwood; Ajay M Shah; Mark T Kearney
Divergent effects of angiotensin-converting enzyme inhibition on blood pressure and endothelial function in obese humans.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2006;3(1):34-8.
2005: William H T Smith; R Unnikrishnan Nair; Dawn Adamson; Mark T Kearney; Stephen G Ball; Anthony J Balmforth
Somatostatin receptor subtype expression in the human heart: differential expression by myocytes and fibroblasts.
The Journal of endocrinology 2005;187(3):379-86.
2005: S Kapetanakis; Mark T Kearney; A Siva; Nicholas P Gall; M Cooklin; MJ Monaghan
Real-time three-dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony.
Circulation 2005;112(7):992-1000.
2005: Ian L Williams; Philip J Chowienczyk; Stephen B Wheatcroft; Ameet Patel; Roy A Sherwood; Aziz U Momin; Ajay M Shah; Mark T Kearney
Endothelial function and weight loss in obese humans.
Obesity surgery 2005;15(7):1055-60.
2005: Azfar G Zaman; Mark T Kearney
Reply to Ogimoto, angiotensin-converting enzyme inhibitors as a new therapy for atrial fibrillation? Controversy (Am Heart J 2005;149:e19.).
American heart journal 2005;150(1):e5.
2005: Brian T Noronha; Jian-Mei Li; Stephen B Wheatcroft; Ajay M Shah; Mark T Kearney
Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity.
Diabetes 2005;54(4):1082-9.
2004: Stephen B Wheatcroft; Ajay M Shah; Jian-Mei Li; Edward Duncan; Brian T Noronha; Paul A Crossey; Mark T Kearney
Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor.
Diabetes 2004;53(10):2645-52.
2004: Mark T Kearney; Keith A A Fox; A J Lee; W Paul Brooksby; Ajay M Shah; Andrew D Flapan; Robin J Prescott; R Andrews; Philip D Batin; Dwain L Eckberg; Nicholas P Gall; Azfar G Zaman; H S Lindsay; J Nolan
Predicting sudden death in patients with mild to moderate chronic heart failure.
Heart (British Cardiac Society) 2004;90(10):1137-43.
2004: Azfar G Zaman; Mark T Kearney; Clyde Schecter; Stephen G Worthley; James Nolan
Angiotensin-converting enzyme inhibitors as adjunctive therapy in patients with persistent atrial fibrillation.
American heart journal 2004;147(5):823-7.
2004: Jian-Mei Li; Stephen B Wheatcroft; Lampson M Fan; Mark T Kearney; Ajay M Shah
Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.
Circulation 2004;109(10):1307-13.
2003: Andrew D Stewart; Sandrine C Millasseau; Mark T Kearney; James M Ritter; Philip J Chowienczyk
Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans.
Hypertension 2003;42(5):915-8.
2003: Mark T Kearney; James Nolan; Amanda J Lee; Paul W Brooksby; Robin J Prescott; Ajay M Shah; Azfar G Zaman; Dwain L Eckberg; H Stephen Lindsay; Philip D Batin; Richard Andrews; Keith A A Fox
A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors.
European journal of heart failure 2003;5(4):489-97.
2003: Stephen B Wheatcroft; Mark T Kearney; Ajay M Shah; David J Grieve; Ian L Williams; John P Miell; Paul A Crossey
Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.
Diabetes 2003;52(8):2075-82.
2003: Philip A MacCarthy; Mark T Kearney; James Nolan; Amanda J Lee; Robin J Prescott; Ajay M Shah; W Paul Brooksby; Keith A A Fox
Prognosis in heart failure with preserved left ventricular systolic function: prospective cohort study.
BMJ (Clinical research ed.) 2003;327(7406):78-9.
2003: Mark T Kearney; Azfar Zaman; Dwain L Eckberg; Amanda J Lee; Keith A A Fox; Ajay M Shah; Robin J Prescott; William E Shell; Elizabeth Charuvastra; Timothy S Callahan; W Paul Brooksby; D Justin Wright; Nicholas P Gall; James Nolan
Cardiac size, autonomic function, and 5-year follow-up of chronic heart failure patients with severe prolongation of ventricular activation.
Journal of cardiac failure 2003;9(2):93-9.
2002: J M Cotton; Mark T Kearney; Ajay M Shah
Nitric oxide and myocardial function in heart failure: friend or foe?
Heart (British Cardiac Society) 2002;88(6):564-6.
2002: Mark T Kearney; Keith A A Fox; Amanda J Lee; Robin J Prescott; Ajay M Shah; Philip D Batin; Wazir Baig; Stephen Lindsay; Timothy S Callahan; William E Shell; Dwain L Eckberg; Azfar G Zaman; Simon Williams; James M M Neilson; James Nolan
Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure.
Journal of the American College of Cardiology 2002;40(10):1801-8.
2002: Ian L Williams; Stephen B Wheatcroft; Ajay M Shah; Mark T Kearney
Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(6):754-64.
2002: Mark T Kearney; Philip J Chowienczyk; Sally E Brett; Angela Sutcliffe; James M Ritter; Ajay M Shah
Acute haemodynamic effects of lipolysis-induced increase of free fatty acids in healthy men.
Clinical science (London, England : 1979) 2002;102(5):495-500.
2001: J M Cotton; Mark T Kearney; Philip A MacCarthy; RM Grocott-Mason; Dougal R McClean; Christophe Heymes; Peter J Richardson; Ajay M Shah
Effects of nitric oxide synthase inhibition on Basal function and the force-frequency relationship in the normal and failing human heart in vivo.
Circulation 2001;104(19):2318-23.
2001: Nicholas P Gall; Mark T Kearney; A Zaman; S O'Nunain; Keith A A Fox; Andrew D Flapan; J Nolan
Implementation of the NICE guidelines for the primary prevention of mortality from ventricular tachyarrhythmias: implications for UK electrophysiology centres; activity modelling from the UK-HEART study.
Heart (British Cardiac Society) 2001;86(2):219-20.
2001: Mark T Kearney; J M Cotton; Peter J Richardson; Ajay M Shah
Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management.
Postgraduate medical journal 2001;77(903):4-10.
2000: J M Cotton; Mark T Kearney; Ray J Wainwright
Shifting the balance: direct stenting a novel approach to improve the cost effectiveness of intra-coronary stenting.
European heart journal 2000;21(2):170.