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Thomas Keating

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Thomas A Keating; C Gary Marshall; Christopher T Walsh; Amy E Keating
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.
Deborah Ann Miller; Lusong Luo; Nathan J Hillson; Thomas A Keating; Christopher T Walsh
Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis.
Christopher T Walsh; Huawei Chen; Thomas A Keating; Brian K Hubbard; Heather C Losey; Lusong Luo; C Gary Marshall; Deborah Ann Miller; Hiten M Patel
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.

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All Publications

2002: Thomas A Keating; C Gary Marshall; Christopher T Walsh; Amy E Keating
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.
Nature structural biology 2002;9(7):522-6.
2002: Deborah Ann Miller; Lusong Luo; Nathan J Hillson; Thomas A Keating; Christopher T Walsh
Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis.
Chemistry & biology 2002;9(3):333-44.
2001: Christopher T Walsh; Huawei Chen; Thomas A Keating; Brian K Hubbard; Heather C Losey; Lusong Luo; C Gary Marshall; Deborah Ann Miller; Hiten M Patel
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.
Current opinion in chemical biology 2001;5(5):525-34.
2001: C Gary Marshall; Michael D Burkart; Thomas A Keating; Christopher T Walsh
Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate.
Biochemistry 2001;40(35):10655-63.
2001: Thomas A Keating; DE Ehmann; Rahul Kohli; C Gary Marshall; JW Trauger; Christopher T Walsh
Chain termination steps in nonribosomal peptide synthetase assembly lines: directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis.
Chembiochem : a European journal of chemical biology 2001;2(2):99-107.
2000: Thomas A Keating; C Gary Marshall; Christopher T Walsh
Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH.
Biochemistry 2000;39(50):15522-30.
2000: Thomas A Keating; C Gary Marshall; Christopher T Walsh
Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains.
Biochemistry 2000;39(50):15513-21.
2000: Thomas A Keating; Deborah Ann Miller; Christopher T Walsh
Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase.
Biochemistry 2000;39(16):4729-39.
2000: Thomas A Keating; Z Suo; DE Ehmann; Christopher T Walsh
Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain.
Biochemistry 2000;39(9):2297-306.
1999: LE Quadri; Thomas A Keating; Hiten M Patel; Christopher T Walsh
Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF.
Biochemistry 1999;38(45):14941-54.
1999: Thomas A Keating; Christopher T Walsh
Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis.
Current opinion in chemical biology 1999;3(5):598-606.
1998: LE Quadri; J Sello; Thomas A Keating; Paul H Weinreb; Christopher T Walsh
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
Chemistry & biology 1998;5(11):631-45.