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Patricia Keely

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Publications

TOP 3
Craig E Barcus; Kevin W Eliceiri; Patricia J Keely; Linda A Schuler
Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells.
Colleen S Curran; Patricia J Keely
Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition.
Scott Gehler; Suzanne M Ponik; Kristin M Riching; Patricia J Keely
Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression.

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All Publications

2013: Craig E Barcus; Kevin W Eliceiri; Patricia J Keely; Linda A Schuler
Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells.
The Journal of biological chemistry 2013;288(18):12722-32.
2013: Colleen S Curran; Patricia J Keely
Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition.
Matrix biology : journal of the International Society for Matrix Biology 2013;32(2):95-105.
2013: Scott Gehler; Suzanne M Ponik; Kristin M Riching; Patricia J Keely
Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression.
Critical reviews in eukaryotic gene expression 2013;23(2):139-57.
2012: Jessica N Heck; David R Inman; Kevin W Eliceiri; Maria G Garcia-Mendoza; Carolyn A Pehlke; Suzanne M Ponik; Patricia J Keely
Microtubules regulate GEF-H1 in response to extracellular matrix stiffness.
Molecular biology of the cell 2012;23(13):2583-92.
2012: Matthew W Conklin; Patricia J Keely
Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers.
Cell adhesion & migration 2012;6(3):249-60.
2011: Patricia J Keely
Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion.
Journal of mammary gland biology and neoplasia 2011;16(3):205-19.
2011: Traci R. Lyons; Andriy Marusyk; Jenean O'Brien; Virginia Borges; Matthew W Conklin; Kevin W Eliceiri; Patricia J Keely; Aik Choon Tan; Pepper Schedin
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
Nature medicine 2011;17(9):1109-15.
2011: Visar Ajeti; Kevin W Eliceiri; Patricia J Keely; Oleg Nadiarnykh; Suzanne M Ponik; Paul J Campagnola
Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer.
Biomedical optics express 2011;2(8):2307-16.
2011: Kyung Eun Sung; Ning Yang; Carolyn Pehlke; Patricia J Keely; Kevin W Eliceiri; Andreas Friedl; David J Beebe
Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects.
Integrative biology : quantitative biosciences from nano to macro 2011;3(4):439-50.
2010: Matthew W Conklin; Aude Ada-Nguema; Maddy Parsons; Kristin M Riching; Patricia J Keely
R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis.
BMC cell biology 2010;11():14.
2009: Paolo P Provenzano; D R Inman; Kevin W Eliceiri; Patricia J Keely
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.
Oncogene 2009;28(49):4326-43.
2009: Paolo P Provenzano; Kevin W Eliceiri; Patricia J Keely
Shining new light on 3D cell motility and the metastatic process.
Trends in cell biology 2009;19(11):638-48.
2009: Paolo P Provenzano; Patricia J Keely
The role of focal adhesion kinase in tumor initiation and progression.
Cell adhesion & migration 2009;3(4):347-50.
2009: Kyung Eun Sung; Gui Su; Carolyn Pehlke; Steven M Trier; Kevin W Eliceiri; Patricia J Keely; Andreas Friedl; David J Beebe
Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices.
Biomaterials 2009;30(27):4833-41.
2009: Scott Gehler; Massimiliano Baldassarre; Yatish Lad; Jennifer L Leight; Michele A Wozniak; Kristin M Riching; Kevin W Eliceiri; Valerie M Weaver; David A Calderwood; Patricia J Keely
Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.
Molecular biology of the cell 2009;20(14):3224-38.
2009: Curtis T Rueden; MW Conklin; Paolo P Provenzano; Patricia J Keely; Kevin W Eliceiri
Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2009;2009():4077-80.
2009: MW Conklin; Paolo P Provenzano; Kevin W Eliceiri; Ruth Sullivan; Patricia J Keely
Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast.
Cell biochemistry and biophysics 2009;53(3):145-57.
2009: Paolo P Provenzano; Kevin W Eliceiri; Patricia J Keely
Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment.
Clinical & experimental metastasis 2009;26(4):357-70.
2008: Paolo P Provenzano; Kevin W Eliceiri; Long Yan; Aude Ada-Nguema; MW Conklin; David R Inman; Patricia J Keely
Nonlinear optical imaging of cellular processes in breast cancer.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2008;14(6):532-48.
2008: Paolo P Provenzano; David R Inman; Kevin W Eliceiri; Steven M Trier; Patricia J Keely
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization.
Biophysical journal 2008;95(11):5374-84.
2008: Paolo P Provenzano; David R Inman; Kevin W Eliceiri; Hilary E Beggs; Patricia J Keely
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.
The American journal of pathology 2008;173(5):1551-65.
2008: Paolo P Provenzano; Curtis T Rueden; Steve M Trier; Long Yan; Suzanne M Ponik; David R Inman; Patricia J Keely; Kevin W Eliceiri
Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer.
Journal of biomedical optics 2008;13(3):031220.
2008: Paolo P Provenzano; David R Inman; Kevin W Eliceiri; Justin G Knittel; Long Yan; Curtis T Rueden; John G White; Patricia J Keely
Collagen density promotes mammary tumor initiation and progression.
BMC medicine 2008;6():11.
2007: Melissa Skala; Kristin M Riching; Damian K Bird; Annette Gendron-Fitzpatrick; Jens Eickhoff; Kevin W Eliceiri; Patricia J Keely; Nirmala Ramanujam
In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia.
Journal of biomedical optics 2007;12(2):024014.
2007: Patricia J Keely; Matthew W Conklin; Scott Gehler; Suzanne M Ponik; Paolo P Provenzano
Investigating integrin regulation and signaling events in three-dimensional systems.
Methods in enzymology 2007;426():27-45.
2006: Katarzyna Modzelewska; Laura P Newman; Radhika Desai; Patricia J Keely
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
The Journal of biological chemistry 2006;281(49):37527-35.
2006: Saumen Pal; Jing Wu; Justin K Murray; Samuel H Gellman; Michele A Wozniak; Patricia J Keely; Meghan E Boyer; Timothy M Gomez; Sean M Hasso; John Fallon; Emery H Bresnick
An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis.
The Journal of cell biology 2006;174(7):1047-58.
2006: Aude S Ada-Nguema; Harry S Xenias; Jake M Hofman; Chris H Wiggins; Michael P Sheetz; Patricia J Keely
The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon.
Journal of cell science 2006;119(Pt 7):1307-19.
2006: Paolo P Provenzano; Kevin W Eliceiri; Jay M Campbell; David R Inman; John G White; Patricia J Keely
Collagen reorganization at the tumor-stromal interface facilitates local invasion.
BMC medicine 2006;4(1):38.
2005: Damian K Bird; Long Yan; Kristin M Vrotsos; Kevin W Eliceiri; Emily Vaughan; Patricia J Keely; John G White; Nirmala Ramanujam
Metabolic mapping of MCF10A human breast cells via multiphoton fluorescence lifetime imaging of the coenzyme NADH.
Cancer research 2005;65(19):8766-73.
2005: Michele A Wozniak; Patricia J Keely
Use of three-dimensional collagen gels to study mechanotransduction in T47D breast epithelial cells.
Biological procedures online 2005;7():144-61.
2005: Michele A Wozniak; Lina Kwong; David Chodniewicz; Richard L Klemke; Patricia J Keely
R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho.
Molecular biology of the cell 2005;16(1):84-96.
2004: Michele A Wozniak; Katarzyna Modzelewska; Lina Kwong; Patricia J Keely
Focal adhesion regulation of cell behavior.
Biochimica et biophysica acta 2004;1692(2-3):103-19.
2003: Michele A Wozniak; Radhika Desai; Patricia A Solski; Channing J Der; Patricia J Keely
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix.
The Journal of cell biology 2003;163(3):583-95.
2003: Gregory Palmer; Patricia J Keely; Tara M Breslin; Nirmala Ramanujam
Autofluorescence spectroscopy of normal and malignant human breast cell lines.
Photochemistry and photobiology 2003;78(5):462-9.
2003: Lina Kwong; Michele A Wozniak; Asha S Collins; Siobhan D Wilson; Patricia J Keely
R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins.
Molecular and cellular biology 2003;23(3):933-49.
2002: Patricia A Solski; Whitney Helms; Patricia J Keely; Lishan Su; Channing J Der
RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(8):363-73.
2002: Veronica Gabarra-Niecko; Patricia J Keely; Michael D Schaller
Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'.
The Biochemical journal 2002;365(Pt 3):591-603.
2001: Patricia J Keely
Rho GTPases as early markers for tumour progression.
Lancet 2001;358(9295):1744-5.
2001: Patricia J Keely
Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells.
Methods in enzymology 2001;333():256-66.
1999: K M Eisenmann; James B McCarthy; Melanie A Simpson; Patricia J Keely; Jun-Lin Guan; K Tachibana; L Lim; E Manser; Leo T Furcht; Joji Iida
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Nature cell biology 1999;1(8):507-13.
1999: Patricia J Keely; Elena V Rusyn; Adrienne D Cox; Leslie V Parise
R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells.
The Journal of cell biology 1999;145(5):1077-88.
1998: Patricia J Keely; Leslie V Parise; Rudy L Juliano
Integrins and GTPases in tumour cell growth, motility and invasion.
Trends in cell biology 1998;8(3):101-6.
1997: Patricia J Keely; JK Westwick; Ian P Whitehead; Channing J Der; Leslie V Parise
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.
Nature 1997;390(6660):632-6.
1996: Patricia J Keely; Leslie V Parise
The alpha2beta1 integrin is a necessary co-receptor for collagen-induced activation of Syk and the subsequent phosphorylation of phospholipase Cgamma2 in platelets.
The Journal of biological chemistry 1996;271(43):26668-76.