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Richard Keenan

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Antony N Shaw; Rosanna Tedesco; Ramesh Bambal; Deping Chai; Nestor O Concha; Michael G Darcy; Dashyant Dhanak; Kevin J Duffy; Duke M Fitch; Adam T Gates; Victor K Johnston; Richard M Keenan; Juili Lin-Goerke; Nannan Liu; Robert T Sarisky; Kenneth J Wiggall; Michael N Zimmerman
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Rosanna Tedesco; Deping Chai; Michael G Darcy; Dashyant Dhanak; Duke M Fitch; Adam T Gates; Victor K Johnston; Richard M Keenan; Juili Lin-Goerke; Robert T Sarisky; Antony N Shaw; Klara L Valko; Kenneth J Wiggall; Michael N Zimmerman; Kevin J Duffy
Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.
Robert W Marquis; Amparo M Lago; James F Callahan; Robert E Lee Trout; Maxine Gowen; Eric G DelMar; Bradford C Van Wagenen; Sarah Logan; Scott Shimizu; John Fox; Edward F Nemeth; Zheng Yang; Theresa Roethke; Brian R Smith; Keith W Ward; John Lee; Richard M Keenan; Pradip Bhatnagar
Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.

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All Publications

2009: Antony N Shaw; Rosanna Tedesco; Ramesh Bambal; Deping Chai; Nestor O Concha; Michael G Darcy; Dashyant Dhanak; Kevin J Duffy; Duke M Fitch; Adam T Gates; Victor K Johnston; Richard M Keenan; Juili Lin-Goerke; Nannan Liu; Robert T Sarisky; Kenneth J Wiggall; Michael N Zimmerman
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Bioorganic & medicinal chemistry letters 2009;19(15):4350-3.
2009: Rosanna Tedesco; Deping Chai; Michael G Darcy; Dashyant Dhanak; Duke M Fitch; Adam T Gates; Victor K Johnston; Richard M Keenan; Juili Lin-Goerke; Robert T Sarisky; Antony N Shaw; Klara L Valko; Kenneth J Wiggall; Michael N Zimmerman; Kevin J Duffy
Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4354-8.
2009: Robert W Marquis; Amparo M Lago; James F Callahan; Robert E Lee Trout; Maxine Gowen; Eric G DelMar; Bradford C Van Wagenen; Sarah Logan; Scott Shimizu; John Fox; Edward F Nemeth; Zheng Yang; Theresa Roethke; Brian R Smith; Keith W Ward; John Lee; Richard M Keenan; Pradip Bhatnagar
Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.
Journal of medicinal chemistry 2009;52(13):3982-93.
2006: Igor G Safonov; Dirk A Heerding; Richard M Keenan; Alan T Price; Connie L Erickson-Miller; Christopher B Hopson; Jenna L Levin; Kenneth A Lord; Peter M Tapley
New benzimidazoles as thrombopoietin receptor agonists.
Bioorganic & medicinal chemistry letters 2006;16(5):1212-6.
2006: Rosanna Tedesco; Antony N Shaw; Ramesh Bambal; Deping Chai; Nestor O Concha; Michael G Darcy; Dashyant Dhanak; Duke M Fitch; Adam T Gates; Warren G Gerhardt; Dina L Halegoua; Chao Han; Glenn Hofmann; Victor K Johnston; Arun C Kaura; Nannan Liu; Richard M Keenan; Juili Lin-Goerke; Robert T Sarisky; Kenneth J Wiggall; Michael N Zimmerman; Kevin J Duffy
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Journal of medicinal chemistry 2006;49(3):971-83.
2005: Jian Jin; Dashyant Dhanak; Steven D Knight; Katherine L Widdowson; Nambi Aiyar; Diane Naselsky; Henry M Sarau; James J Foley; Dulcie B Schmidt; Carl D Bennett; Bing Wang; Gregory L Warren; Michael L Moore; Richard M Keenan; Ralph A Rivero; Stephen Douglas
Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(13):3229-32.
2005: Stephen Douglas; David J Behm; Nambi Aiyar; Diane Naselsky; Jyoti Disa; David P Brooks; Eliot ohlstein; John G Gleason; Henry M Sarau; James J Foley; Peter T Buckley; Dulcie B Schmidt; William E Wixted; Katherine L Widdowson; Graham Riley; Jian Jin; Timothy F Gallagher; Stanley J Schmidt; Lance H Ridgers; Lisa T Christmann; Richard M Keenan; Steven D Knight; Dashyant Dhanak
Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375.
British journal of pharmacology 2005;145(5):620-35.
2005: George Burton; Thomas W Ku; Thomas J Carr; Terry Kiesow; Robert T Sarisky; Juili Lin-Goerke; Audrey Baker; David L Earnshaw; Glenn Hofmann; Richard M Keenan; Dashyant Dhanak
Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
Bioorganic & medicinal chemistry letters 2005;15(6):1553-6.
2003: Michael Doyle; Shin-Shay Tian; Stephen G Miller; Linda Kessler; Audrey E Baker; Michael Brigham-Burke; Susan B Dillon; Kevin J Duffy; Richard M Keenan; Ruth Lehr; Jon Rosen; Lumelle Schneeweis; John Trill; Peter Young; Juan I Luengo; Peter Lamb
Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.
The Journal of biological chemistry 2003;278(11):9426-34.
2002: Dashyant Dhanak; Kevin J Duffy; Victor K Johnston; Juili Lin-Goerke; Michael G Darcy; Antony N Shaw; Baohua Gu; Carol Silverman; Adam T Gates; Michael Nonnemacher; David L Earnshaw; David J Casper; Arun C Kaura; Audrey Baker; Cathy Greenwood; Lester L Gutshall; Derrick Maley; Alfred DelVecchio; Ricardo Macarron; Glenn Hofmann; Zaid Alnoah; Hung-Yuan Cheng; George Chan; Sanjay S Khandekar; Richard M Keenan; Robert T Sarisky
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
The Journal of biological chemistry 2002;277(41):38322-7.
2002: Kevin J Duffy; Alan T Price; Evelyne Delorme; Susan B Dillon; Celine Duquenne; Connie L Erickson-Miller; Leslie Giampa; Yifang Huang; Richard M Keenan; Peter Lamb; Nannan Liu; Stephen G Miller; Jon Rosen; Antony N Shaw; Heather Smith; Kenneth J Wiggall; Lihua Zhang; Juan I Luengo
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.
Journal of medicinal chemistry 2002;45(17):3576-8.
2002: Kevin J Duffy; Antony N Shaw; Evelyne Delorme; Susan B Dillon; Connie L Erickson-Miller; Leslie Giampa; Yifang Huang; Richard M Keenan; Peter Lamb; Nannan Liu; Stephen G Miller; Alan T Price; Jon Rosen; Heather Smith; Kenneth J Wiggall; Lihua Zhang; Juan I Luengo
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.
Journal of medicinal chemistry 2002;45(17):3573-5.
2001: Kevin J Duffy; Michael G Darcy; Evelyne Delorme; Susan B Dillon; D F Eppley; Connie L Erickson-Miller; Leslie Giampa; Christopher B Hopson; Yifang Huang; Richard M Keenan; Peter Lamb; L Leong; Nannan Liu; Stephen G Miller; Alan T Price; Jon Rosen; R Shah; T N Shaw; Heather Smith; K C Stark; Shin-Shay Tian; Curtis Tyree; Kenneth J Wiggall; Lihua Zhang; Juan I Luengo
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
Journal of medicinal chemistry 2001;44(22):3730-45.
2001: Dashyant Dhanak; Lisa T Christmann; Michael G Darcy; Richard M Keenan; Steven D Knight; J Lee; Lance H Ridgers; Henry M Sarau; DH Shah; John White; Lihua Zhang
Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.
Bioorganic & medicinal chemistry letters 2001;11(11):1445-50.
2001: Dashyant Dhanak; Lisa T Christmann; Michael G Darcy; Anthony Jurewicz; Richard M Keenan; J Lee; Henry M Sarau; Katherine L Widdowson; John White
Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1.
Bioorganic & medicinal chemistry letters 2001;11(11):1441-4.
2000: Dashyant Dhanak; George Burton; Lisa T Christmann; Michael G Darcy; Kyle Elrod; Arun C Kaura; Richard M Keenan; J O Link; CE Peishoff; DH Shah
Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease.
Bioorganic & medicinal chemistry letters 2000;10(20):2279-82.
1999: Keith W Ward; Leonard M Azzarano; WE Bondinell; Russell D Cousins; William F Huffman; Dalia R Jakas; Richard M Keenan; Thomas W Ku; David Lundberg; William H Miller; J A Mumaw; Kenneth A Newlander; J L Pirhalla; Theresa J Roethke; Kevin L Salyers; P R Souder; Gary J Stelman; Brian R Smith
Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(11):1232-41.
1999: Kevin J Duffy; Lance H Ridgers; RL DesJarlais; Thaddeus Tomaszek; MJ Bossard; Scott K Thompson; Richard M Keenan; Daniel F Veber
Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K.
Bioorganic & medicinal chemistry letters 1999;9(14):1907-10.
1999: William H Miller; WE Bondinell; Russell D Cousins; Karl F Erhard; Dalia R Jakas; Richard M Keenan; Thomas W Ku; Kenneth A Newlander; Stephen T Ross; R Curtis Haltiwanger; JN Bradbeer; FH Drake; Maxine Gowen; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; Michael W Lark; BA Lechowska; David J Rieman; George B Stroup; Janice Vasko-Moser; DL Zembryki; Leonard M Azzarano; P C Adams; William F Huffman
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Bioorganic & medicinal chemistry letters 1999;9(13):1807-12.
1999: Richard M Keenan; William H Miller; L S Barton; WE Bondinell; Russell D Cousins; D F Eppley; Shing-Mei Hwang; Chet Kwon; MA Lago; TT Nguyen; Brian R Smith; Irene N Uzinskas; Catherine C K Yuan
Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics.
Bioorganic & medicinal chemistry letters 1999;9(13):1801-6.
1999: Richard M Keenan; James F Callahan; James Samanen; WE Bondinell; RR Calvo; L Chen; C DeBrosse; Drake S Eggleston; R Curtis Haltiwanger; Shing-Mei Hwang; Dalia R Jakas; Thomas W Ku; William H Miller; Kenneth A Newlander; A Nichols; M F Parker; L S Southhall; Irene N Uzinskas; Janice Vasko-Moser; J W Venslavsky; A S Wong; William F Huffman
Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.
Journal of medicinal chemistry 1999;42(4):545-59.
1998: Dashyant Dhanak; Richard M Keenan; George Burton; Arun C Kaura; Michael G Darcy; DH Shah; Lance H Ridgers; A Breen; P Lavery; David Tew; Andrew West
Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease.
Bioorganic & medicinal chemistry letters 1998;8(24):3677-82.
1998: Richard M Keenan; MA Lago; William H Miller; FE Ali; Russell D Cousins; L B Hall; Shing-Mei Hwang; Dalia R Jakas; Chet Kwon; CS Louden; TT Nguyen; Eliot ohlstein; David J Rieman; Stephen T Ross; James Samanen; Brian R Smith; JM Stadel; Dennis T Takata; L Vickery; Catherine C K Yuan; Tian-Li Yue
Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model.
Bioorganic & medicinal chemistry letters 1998;8(22):3171-6.
1998: Richard M Keenan; William H Miller; MA Lago; FE Ali; WE Bondinell; James F Callahan; RR Calvo; Russell D Cousins; Shing-Mei Hwang; Dalia R Jakas; Thomas W Ku; Chet Kwon; TT Nguyen; V A Reader; David J Rieman; Stephen T Ross; Dennis T Takata; Irene N Uzinskas; Catherine C K Yuan; Brian R Smith
Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
Bioorganic & medicinal chemistry letters 1998;8(22):3165-70.
1997: Richard M Keenan; William H Miller; Chet Kwon; FE Ali; James F Callahan; RR Calvo; Shing-Mei Hwang; K D Kopple; CE Peishoff; James Samanen; A S Wong; C K Yuan; William F Huffman
Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
Journal of medicinal chemistry 1997;40(15):2289-92.
1996: James Samanen; FE Ali; L S Barton; WE Bondinell; J L Burgess; James F Callahan; Raul Calvo; W Chen; L Chen; Karl F Erhard; G Feuerstein; R Heys; Shing-Mei Hwang; Dalia R Jakas; Richard M Keenan; Thomas W Ku; Chet Kwon; C P Lee; William H Miller; Kenneth A Newlander; A Nichols; M Parker; C E Peishoff; G Rhodes; S Ross; A Shu; R Simpson; Dennis T Takata; T O Yellin; I Uzsinskas; J W Venslavsky; C K Yuan; William F Huffman
Potent, selective, orally active 3-oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists.
Journal of medicinal chemistry 1996;39(25):4867-70.
1995: Thomas W Ku; William H Miller; WE Bondinell; Karl F Erhard; Richard M Keenan; A J Nichols; C E Peishoff; James Samanen; A S Wong; William F Huffman
Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore.
Journal of medicinal chemistry 1995;38(1):9-12.
1994: WE Bondinell; Richard M Keenan; William H Miller; FE Ali; A C Allen; C W de Brosse; Drake S Eggleston; Karl F Erhard; R Curtis Haltiwanger; William F Huffman
Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist.
Bioorganic & medicinal chemistry 1994;2(9):897-908.
1993: Richard M Keenan; J Weinstock; J A Finkelstein; R G Franz; D E Gaitanopoulos; G R Girard; D T Hill; T M Morgan; James Samanen; C E Peishoff
Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.
Journal of medicinal chemistry 1993;36(13):1880-92.
1992: Richard M Keenan; J Weinstock; J A Finkelstein; R G Franz; D E Gaitanopoulos; G R Girard; D T Hill; T M Morgan; James Samanen; J Hempel
Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.
Journal of medicinal chemistry 1992;35(21):3858-72.
1992: Richard M Edwards; EJ Stack; E F Weidley; Nambi Aiyar; Richard M Keenan; D T Hill; J Weinstock
Characterization of renal angiotensin II receptors using subtype selective antagonists.
The Journal of pharmacology and experimental therapeutics 1992;260(3):933-8.
1992: Richard M Edwards; Nambi Aiyar; Eliot ohlstein; E F Weidley; E Griffin; M Ezekiel; Richard M Keenan; RR Ruffolo; J Weinstock
Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.
The Journal of pharmacology and experimental therapeutics 1992;260(1):175-81.
1991: J Weinstock; Richard M Keenan; James Samanen; J Hempel; J A Finkelstein; R G Franz; D E Gaitanopoulos; G R Girard; J G Gleason; D T Hill
1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.
Journal of medicinal chemistry 1991;34(4):1514-7.