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Jack Keene

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Laura E Simone; Jack D Keene
Mechanisms coordinating ELAV/Hu mRNA regulons.
Kyle D Mansfield; Jack D Keene
Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation.
Neelanjan Mukherjee; Jeffrey D Nusbaum; Uwe Ohler; David W Reid; Thomas Tuschl; Manuel Ascano; David L Corcoran; Stoyan Georgiev; Markus Hafner; Jack D Keene
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.

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All Publications

2013: Laura E Simone; Jack D Keene
Mechanisms coordinating ELAV/Hu mRNA regulons.
Current opinion in genetics & development 2013;23(1):35-43.
2012: Kyle D Mansfield; Jack D Keene
Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation.
Nucleic acids research 2012;40(6):2734-46.
2011: Neelanjan Mukherjee; Jeffrey D Nusbaum; Uwe Ohler; David W Reid; Thomas Tuschl; Manuel Ascano; David L Corcoran; Stoyan Georgiev; Markus Hafner; Jack D Keene
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.
Molecular cell 2011;43(3):327-39.
2011: Krystyna Mazan-Mamczarz; Patrick R Hagner; Yongqing Zhang; Bojie Dai; Elin Lehrmann; Kevin G Becker; Jack D Keene; Myriam Gorospe; Zhenqiu Liu; Ronald B Gartenhaus
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
Blood 2011;117(8):2441-50.
2011: David L Corcoran; Stoyan Georgiev; Eva Gottwein; Jack D Keene; Neelanjan Mukherjee; Rebecca L Skalsky; Uwe Ohler
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data.
Genome biology 2011;12(8):R79.
2010: Jack D Keene
Minireview: global regulation and dynamics of ribonucleic Acid.
Endocrinology 2010;151(4):1391-7.
2010: Adam R Morris; Neelanjan Mukherjee; Jack D Keene
Systematic analysis of posttranscriptional gene expression.
Wiley interdisciplinary reviews. Systems biology and medicine 2010;2(2):162-80.
2010: Valentina Neplioueva; Elena Y Dobrikova; Neelanjan Mukherjee; Jack D Keene; Matthias Gromeier
Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.
PloS one 2010;5(7):e11710.
2010: Jack D Keene
The global dynamics of RNA stability orchestrates responses to cellular activation.
BMC biology 2010;8():95.
2009: Kyle D Mansfield; Jack D Keene
The ribonome: a dominant force in co-ordinating gene expression.
Biology of the cell / under the auspices of the European Cell Biology Organization 2009;101(3):169-81.
2009: Neelanjan Mukherjee; Patrick J Lager; Matthew B Friedersdorf; Marshall A Thompson; Jack D Keene
Coordinated posttranscriptional mRNA population dynamics during T-cell activation.
Molecular systems biology 2009;5():288.
2008: Krystyna Mazan-Mamczarz; P R Hagner; S Corl; S Srikantan; W H Wood; Kevin G Becker; Myriam Gorospe; Jack D Keene; A S Levenson; Ronald B Gartenhaus
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Oncogene 2008;27(47):6151-63.
2008: Dhanrajan M Tiruchinapalli; Michael D Ehlers; Jack D Keene
Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons.
RNA biology 2008;5(3):157-68.
2008: Adam R Morris; Neelanjan Mukherjee; Jack D Keene
Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets.
Molecular and cellular biology 2008;28(12):4093-103.
2008: Brook Pyhtila; Tianli Zheng; Patrick J Lager; Jack D Keene; Mary C Reedy; Christopher V Nicchitta
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.
RNA (New York, N.Y.) 2008;14(3):445-53.
2008: Rachid Mazroui; Sergio Di Marco; Eveline Clair; Christopher von Roretz; Scott A Tenenbaum; Jack D Keene; Maya Saleh; Imed-Eddine Gallouzi
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis.
The Journal of cell biology 2008;180(1):113-27.
2007: Jack D Keene
RNA regulons: coordination of post-transcriptional events.
Nature reviews. Genetics 2007;8(7):533-43.
2007: Jack D Keene
Biological clocks and the coordination theory of RNA operons and regulons.
Cold Spring Harbor symposia on quantitative biology 2007;72():157-65.
2006: Jack D Keene; Jordan M Komisarow; Matthew B Friedersdorf
RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts.
Nature protocols 2006;1(1):302-7.
2005: Samuel B Stephens; Rebecca D. Dodd; Joseph W Brewer; Patrick J Lager; Jack D Keene; Christopher V Nicchitta
Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation.
Molecular biology of the cell 2005;16(12):5819-31.
2005: Jack D Keene; Patrick J Lager
Post-transcriptional operons and regulons co-ordinating gene expression.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2005;13(3):327-37.
2004: Luiz Penalva; Jack D Keene
Biotinylated tags for recovery and characterization of ribonucleoprotein complexes.
BioTechniques 2004;37(4):604, 606, 608-10.
2004: Luiz Penalva; Michael D Burdick; Simon M Lin; Hedwig Sutterluety; Jack D Keene
RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells.
Molecular cancer 2004;3():24.
2004: Daniel J Kenan; Jack D Keene
La gets its wings.
Nature structural & molecular biology 2004;11(4):303-5.
2004: Luiz Penalva; Scott A Tenenbaum; Jack D Keene
Gene expression analysis of messenger RNP complexes.
Methods in molecular biology (Clifton, N.J.) 2004;257():125-34.
2003: Jack D Keene
Posttranscriptional generation of macromolecular complexes.
Molecular cell 2003;12(6):1347-9.
2003: Robert V Intine; Scott A Tenenbaum; Amy L Sakulich; Jack D Keene; Richard J Maraia
Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.
Molecular cell 2003;12(5):1301-7.
2003: Scott A Tenenbaum; Craig C Carson; Ulus Atasoy; Jack D Keene
Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera.
Gene 2003;317(1-2):79-87.
2003: Rachel S Lerner; Robert M Seiser; Tianli Zheng; Patrick J Lager; Mary C Reedy; Jack D Keene; Christopher V Nicchitta
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes.
RNA (New York, N.Y.) 2003;9(9):1123-37.
2003: Krystyna Mazan-Mamczarz; Stefanie Galban; Isabel López De Silanes; Jennifer L Martindale; Ulus Atasoy; Jack D Keene; Myriam Gorospe
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8354-9.
2002: Barbara Lipes; Jack D Keene
Autoimmune epitopes in messenger RNA.
RNA (New York, N.Y.) 2002;8(6):762-71.
2002: Jack D Keene; Scott A Tenenbaum
Eukaryotic mRNPs may represent posttranscriptional operons.
Molecular cell 2002;9(6):1161-7.
2002: Theophany Eystathioy; Edward Chan; Scott A Tenenbaum; Jack D Keene; Kevin Griffith; Marvin Fritzler
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.
Molecular biology of the cell 2002;13(4):1338-51.
2002: Scott A Tenenbaum; Patrick J Lager; Craig C Carson; Jack D Keene
Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays.
Methods (San Diego, Calif.) 2002;26(2):191-8.
2001: Jack D Keene
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7018-24.
2000: Scott A Tenenbaum; Craig C Carson; Patrick J Lager; Jack D Keene
Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14085-90.
2000: Naushad Ali; G J Pruijn; Daniel J Kenan; Jack D Keene; Aleem Siddiqui
Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation.
The Journal of biological chemistry 2000;275(36):27531-40.
2000: Y Nagai; T Tucker; H Ren; Daniel J Kenan; B S Henderson; Jack D Keene; Warren J Strittmatter; James R Burke
Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.
The Journal of biological chemistry 2000;275(14):10437-42.
1999: Dragana Antic; N Lu; Jack D Keene
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.
Genes & development 1999;13(4):449-61.
1999: Jack D Keene
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):5-7.
1999: Daniel J Kenan; Jack D Keene
In vitro selection of aptamers from RNA libraries.
Methods in molecular biology (Clifton, N.J.) 1999;118():217-31.
1998: Ulus Atasoy; J Watson; Dhavalkumar D Patel; Jack D Keene
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.
Journal of cell science 1998;111 ( Pt 21)():3145-56.
1998: Dragana Antic; Jack D Keene
Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus.
Journal of cell science 1998;111 ( Pt 2)():183-97.
1997: Dragana Antic; Jack D Keene
Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression.
American journal of human genetics 1997;61(2):273-8.
1996: F B Gao; Jack D Keene
Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.
Journal of cell science 1996;109 ( Pt 3)():579-89.
1996: Saumitra Das; Daniel J Kenan; D Bocskai; Jack D Keene; Asim Dasgupta
Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.
Journal of virology 1996;70(3):1624-32.
1996: Jack D Keene
RNA recognition by autoantigens and autoantibodies.
Molecular biology reports 1996;23(3-4):173-81.
1996: Jack D Keene
Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies.
Methods in enzymology 1996;267():367-83.
1995: Joelle Romac; Jack D Keene
Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA.
Genes & development 1995;9(11):1400-10.
1995: Renu G Jain; Lucy G Andrews; Kevin Mcgowan; F Gao; Jack D Keene; P P Pekala
Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR.
Nucleic acids symposium series 1995;(33):209-11.
1995: Y N Chang; Daniel J Kenan; Jack D Keene; A Gatignol; Kuan-Teh Jeang
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
Journal of virology 1995;69(1):618-9.
1994: F B Gao; C C Carson; T Levine; Jack D Keene
Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11207-11.
1994: Y N Chang; Daniel J Kenan; Jack D Keene; A Gatignol; Kuan-Teh Jeang
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
Journal of virology 1994;68(11):7008-20.
1994: Joelle Romac; D H Graff; Jack D Keene
The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.
Molecular and cellular biology 1994;14(7):4662-70.
1994: M R Saitta; Frank C Arnett; Jack D Keene
60-kDa Ro protein autoepitopes identified using recombinant polypeptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4192-202.
1994: P H King; T D Levine; robert fremeau; Jack D Keene
Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(4):1943-52.
1994: A Kelekar; M R Saitta; Jack D Keene
Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins.
The Journal of clinical investigation 1994;93(4):1637-44.
1994: Richard J Maraia; Daniel J Kenan; Jack D Keene
Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
Molecular and cellular biology 1994;14(3):2147-58.
1994: Daniel J Kenan; D E Tsai; Jack D Keene
Exploring molecular diversity with combinatorial shape libraries.
Trends in biochemical sciences 1994;19(2):57-64.
1993: Karen Meerovitch; Yuri V Svitkin; Han S Lee; F Lejbkowicz; Daniel J Kenan; Edward Chan; Vadim I Agol; Jack D Keene; Nahum Sonenberg
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Journal of virology 1993;67(7):3798-807.
1993: T D Levine; F Gao; P H King; Lucy G Andrews; Jack D Keene
Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.
Molecular and cellular biology 1993;13(6):3494-504.
1993: D E Tsai; Jack D Keene
In vitro selection of RNA epitopes using autoimmune patient serum.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):1137-45.
1992: D E Tsai; Daniel J Kenan; Jack D Keene
In vitro selection of an RNA epitope immunologically cross-reactive with a peptide.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8864-8.
1992: D S Harper; L D Fresco; Jack D Keene
RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins.
Nucleic acids research 1992;20(14):3645-50.
1992: M R Saitta; Jack D Keene
Molecular biology of nuclear autoantigens.
Rheumatic diseases clinics of North America 1992;18(2):283-310.
1991: D E Tsai; D S Harper; Jack D Keene
U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts.
Nucleic acids research 1991;19(18):4931-6.
1991: Daniel J Kenan; Charles C Query; Jack D Keene
RNA recognition: towards identifying determinants of specificity.
Trends in biochemical sciences 1991;16(6):214-20.
1991: R C Bentley; Jack D Keene
Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein.
Molecular and cellular biology 1991;11(4):1829-39.
1991: E W St Clair; Daniel J Kenan; J A Burch; Jack D Keene; David S Pisetsky
Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1885-92.
1991: D W Hoffman; Charles C Query; Barbara L Golden; Stephen W White; Jack D Keene
RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2495-9.
1991: L D Fresco; D S Harper; Jack D Keene
Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions.
Molecular and cellular biology 1991;11(3):1578-89.
1991: Jack D Keene; Charles C Query
Nuclear RNA-binding proteins.
Progress in nucleic acid research and molecular biology 1991;41():179-202.
1990: C Lutz-Freyermuth; Charles C Query; Jack D Keene
Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6393-7.
1990: E W St Clair; Daniel J Kenan; J A Burch; Jack D Keene; David S Pisetsky
The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3868-76.
1990: E W St Clair; Charles C Query; R Bentley; Jack D Keene; R P Polisson; Nancy B Allen; David S Caldwell; J R Rice; C Cox; David S Pisetsky
Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.
Clinical immunology and immunopathology 1990;54(2):266-80.
1990: E W St Clair; J A Burch; Michael M Ward; Jack D Keene; David S Pisetsky
Temporal correlation of antibody responses to different epitopes of the human La autoantigen.
The Journal of clinical investigation 1990;85(2):515-21.
1990: A Kelekar; Jack D Keene
Downregulation of RNA polymerase III transcription of the hY3 gene in vitro.
Molecular biology reports 1990;14(2-3):173-4.
1990: D S Harper; L D Fresco; Jack D Keene
Characterization of a Drosophila U snRNP RNA-binding protein.
Molecular biology reports 1990;14(2-3):163.
1989: Charles C Query; R C Bentley; Jack D Keene
A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component.
Molecular and cellular biology 1989;9(11):4872-81.
1989: D E Crone; Jack D Keene
Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins.
Journal of virology 1989;63(10):4172-80.
1989: D W Frielle; P B Kim; Jack D Keene
Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis.
Virology 1989;172(1):274-84.
1989: E W St Clair; N Talal; H M Moutsopoulos; A Ballester; L Zerva; Jack D Keene; David S Pisetsky
Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.
Journal of autoimmunity 1989;2(4):335-44.
1989: Jack D Keene
Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics.
Journal of autoimmunity 1989;2(4):329-34.
1989: C Lutz-Freyermuth; Jack D Keene; C Lutz-Reyermuth
The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs.
Molecular and cellular biology 1989;9(7):2975-82.
1989: Charles C Query; R C Bentley; Jack D Keene
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.
Cell 1989;57(1):89-101.
1988: E W St Clair; David S Pisetsky; C F Reich; Jack D Keene
Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4173-80.
1988: J C Chambers; Daniel J Kenan; B J Martin; Jack D Keene
Genomic structure and amino acid sequence domains of the human La autoantigen.
The Journal of biological chemistry 1988;263(34):18043-51.
1988: S L Deutscher; J B Harley; Jack D Keene
Molecular analysis of the 60-kDa human Ro ribonucleoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9479-83.
1988: S L Deutscher; Jack D Keene
A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3299-303.
1988: E W St Clair; David S Pisetsky; C F Reich; J C Chambers; Jack D Keene
Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen.
Arthritis and rheumatism 1988;31(4):506-14.
1987: Charles C Query; Jack D Keene
A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen.
Cell 1987;51(2):211-20.
1987: L D Fresco; M G Kurilla; Jack D Keene
Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus.
Molecular and cellular biology 1987;7(3):1148-55.
1985: R Kole; L D Fresco; Jack D Keene; P L Cohen; R A Eisenberg; P G Andrews
Alu RNA-protein complexes formed in vitro react with a novel lupus autoantibody.
The Journal of biological chemistry 1985;260(21):11781-6.
1985: Jack D Keene
Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression.
Microbiological sciences 1985;2(5):152-6.
1985: J C Chambers; Jack D Keene
Isolation and analysis of cDNA clones expressing human lupus La antigen.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(7):2115-9.
1983: J C Chambers; M G Kurilla; Jack D Keene
Association between the 7 S RNA and the lupus La protein varies among cell types.
The Journal of biological chemistry 1983;258(19):11438-41.