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Jack Keene

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Physiology

Anatomy

Hela Cells

Genes & Molecular Sequences

Amino Acid Sequence

Procedures

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Co-Publications
Name
15
Kenan, Daniel
8
Query, Charles
8
Tenenbaum, Scott
7
Pisetsky, David
7
Lager, Patrick
3
Carson, Craig
3
Antic, D
3
Atasoy, Ulus
3
Nicchitta, Christopher
3
Penalva, Luiz
2
Zheng, Tianli
2
Mazan-Mamczarz, Krystyna
2
Gorospe, Myriam
2
Andrews, Lucy
2
Jeang, Kuan-Teh

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Publications

TOP 3
Mansfield Kyle D; Keene Jack D
The ribonome: a dominant force in co-ordinating gene expression.
Mukherjee Neelanjan; Lager Patrick J; Friedersdorf Matthew B; Thompson Marshall A; Keene Jack D
Coordinated posttranscriptional mRNA population dynamics during T-cell activation.
Mazan-Mamczarz K; Hagner P R; Corl S; Srikantan S; Wood W H; Becker K G; Gorospe M; Keene J D; Levenson A S; Gartenhaus R B
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.

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All Publications

2009: Mansfield Kyle D; Keene Jack D
The ribonome: a dominant force in co-ordinating gene expression.
Biology of the cell / under the auspices of the European Cell Biology Organization 2009;101(3):169-81.
2009: Mukherjee Neelanjan; Lager Patrick J; Friedersdorf Matthew B; Thompson Marshall A; Keene Jack D
Coordinated posttranscriptional mRNA population dynamics during T-cell activation.
Molecular systems biology 2009;5():288.
2008: Mazan-Mamczarz K; Hagner P R; Corl S; Srikantan S; Wood W H; Becker K G; Gorospe M; Keene J D; Levenson A S; Gartenhaus R B
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Oncogene 2008;27(47):6151-63.
2008: Tiruchinapalli Dhanrajan M; Ehlers Michael D; Keene Jack D
Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons.
RNA biology 2008;5(3):157-68.
2008: Morris Adam R; Mukherjee Neelanjan; Keene Jack D
Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets.
Molecular and cellular biology 2008;28(12):4093-103.
2008: Pyhtila Brook; Zheng Tianli; Lager Patrick J; Keene Jack D; Reedy Mary C; Nicchitta Christopher V
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.
RNA (New York, N.Y.) 2008;14(3):445-53.
2008: Mazroui Rachid; Di Marco Sergio; Clair Eveline; von Roretz Christopher; Tenenbaum Scott A; Keene Jack D; Saleh Maya; Gallouzi Imed-Eddine
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis.
The Journal of cell biology 2008;180(1):113-27.
2007: Keene Jack D
RNA regulons: coordination of post-transcriptional events.
Nature reviews. Genetics 2007;8(7):533-43.
2007: Keene J D
Biological clocks and the coordination theory of RNA operons and regulons.
Cold Spring Harbor symposia on quantitative biology 2007;72():157-65.
2006: Keene Jack D; Komisarow Jordan M; Friedersdorf Matthew B
RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts.
Nature protocols 2006;1(1):302-7.
2005: Stephens Samuel B; Dodd Rebecca D; Brewer Joseph W; Lager Patrick J; Keene Jack D; Nicchitta Christopher V
Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation.
Molecular biology of the cell 2005;16(12):5819-31.
2005: Keene Jack D; Lager Patrick J
Post-transcriptional operons and regulons co-ordinating gene expression.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2005;13(3):327-37.
2004: Penalva Luiz O F; Keene Jack D
Biotinylated tags for recovery and characterization of ribonucleoprotein complexes.
BioTechniques 2004;37(4):604, 606, 608-10.
2004: Penalva Luiz O F; Burdick Michael D; Lin Simon M; Sutterluety Hedwig; Keene Jack D
RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells.
Molecular cancer 2004;3():24.
2004: Kenan Daniel J; Keene Jack D
La gets its wings.
Nature structural & molecular biology 2004;11(4):303-5.
2004: Penalva Luiz O F; Tenenbaum Scott A; Keene Jack D
Gene expression analysis of messenger RNP complexes.
Methods in molecular biology (Clifton, N.J.) 2004;257():125-34.
2003: Keene Jack D
Posttranscriptional generation of macromolecular complexes.
Molecular cell 2003;12(6):1347-9.
2003: Intine Robert V; Tenenbaum Scott A; Sakulich Amy L; Keene Jack D; Maraia Richard J
Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.
Molecular cell 2003;12(5):1301-7.
2003: Tenenbaum Scott A; Carson Craig C; Atasoy Ulus; Keene Jack D
Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera.
Gene 2003;317(1-2):79-87.
2003: Lerner Rachel S; Seiser Robert M; Zheng Tianli; Lager Patrick J; Reedy Mary C; Keene Jack D; Nicchitta Christopher V
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes.
RNA (New York, N.Y.) 2003;9(9):1123-37.
2003: Mazan-Mamczarz Krystyna; Galbán Stefanie; López de Silanes Isabel; Martindale Jennifer L; Atasoy Ulus; Keene Jack D; Gorospe Myriam
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8354-9.
2002: Lipes Barbara D; Keene Jack D
Autoimmune epitopes in messenger RNA.
RNA (New York, N.Y.) 2002;8(6):762-71.
2002: Keene Jack D; Tenenbaum Scott A
Eukaryotic mRNPs may represent posttranscriptional operons.
Molecular cell 2002;9(6):1161-7.
2002: Eystathioy Theophany; Chan Edward K L; Tenenbaum Scott A; Keene Jack D; Griffith Kevin; Fritzler Marvin J
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.
Molecular biology of the cell 2002;13(4):1338-51.
2002: Tenenbaum Scott A; Lager Patrick J; Carson Craig C; Keene Jack D
Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays.
Methods (San Diego, Calif.) 2002;26(2):191-8.
2001: Keene J D
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7018-24.
2000: Tenenbaum S A; Carson C C; Lager P J; Keene J D
Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14085-90.
2000: Ali N; Pruijn G J; Kenan D J; Keene J D; Siddiqui A
Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation.
The Journal of biological chemistry 2000;275(36):27531-40.
2000: Nagai Y; Tucker T; Ren H; Kenan D J; Henderson B S; Keene J D; Strittmatter W J; Burke J R
Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.
The Journal of biological chemistry 2000;275(14):10437-42.
1999: Antic D; Lu N; Keene J D
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.
Genes & development 1999;13(4):449-61.
1999: Keene J D
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):5-7.
1999: Kenan D J; Keene J D
In vitro selection of aptamers from RNA libraries.
Methods in molecular biology (Clifton, N.J.) 1999;118():217-31.
1998: Atasoy U; Watson J; Patel D; Keene J D
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.
Journal of cell science 1998;111 ( Pt 21)():3145-56.
1998: Antic D; Keene J D
Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus.
Journal of cell science 1998;111 ( Pt 2)():183-97.
1997: Antic D; Keene J D
Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression.
American journal of human genetics 1997;61(2):273-8.
1996: Gao F B; Keene J D
Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.
Journal of cell science 1996;109 ( Pt 3)():579-89.
1996: Das S; Kenan D J; Bocskai D; Keene J D; Dasgupta A
Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.
Journal of virology 1996;70(3):1624-32.
1996: Keene J D
RNA recognition by autoantigens and autoantibodies.
Molecular biology reports 1996;23(3-4):173-81.
1996: Keene J D
Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies.
Methods in enzymology 1996;267():367-83.
1995: Romac J M; Keene J D
Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA.
Genes & development 1995;9(11):1400-10.
1995: Chang Y N; Kenan D J; Keene J D; Gatignol A; Jeang K T
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
Journal of virology 1995;69(1):618-9.
1995: Jain R G; Andrews L G; McGowan K M; Gao F; Keene J D; Pekala P P
Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR.
Nucleic acids symposium series 1995;(33):209-11.
1994: Gao F B; Carson C C; Levine T; Keene J D
Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11207-11.
1994: Chang Y N; Kenan D J; Keene J D; Gatignol A; Jeang K T
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
Journal of virology 1994;68(11):7008-20.
1994: Romac J M; Graff D H; Keene J D
The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.
Molecular and cellular biology 1994;14(7):4662-70.
1994: King P H; Levine T D; Fremeau R T; Keene J D
Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(4):1943-52.
1994: Kelekar A; Saitta M R; Keene J D
Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins.
The Journal of clinical investigation 1994;93(4):1637-44.
1994: Saitta M R; Arnett F C; Keene J D
60-kDa Ro protein autoepitopes identified using recombinant polypeptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4192-202.
1994: Maraia R J; Kenan D J; Keene J D
Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
Molecular and cellular biology 1994;14(3):2147-58.
1994: Kenan D J; Tsai D E; Keene J D
Exploring molecular diversity with combinatorial shape libraries.
Trends in biochemical sciences 1994;19(2):57-64.
1993: Meerovitch K; Svitkin Y V; Lee H S; Lejbkowicz F; Kenan D J; Chan E K; Agol V I; Keene J D; Sonenberg N
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
Journal of virology 1993;67(7):3798-807.
1993: Levine T D; Gao F; King P H; Andrews L G; Keene J D
Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.
Molecular and cellular biology 1993;13(6):3494-504.
1993: Tsai D E; Keene J D
In vitro selection of RNA epitopes using autoimmune patient serum.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):1137-45.
1992: Tsai D E; Kenan D J; Keene J D
In vitro selection of an RNA epitope immunologically cross-reactive with a peptide.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8864-8.
1992: Harper D S; Fresco L D; Keene J D
RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins.
Nucleic acids research 1992;20(14):3645-50.
1992: Saitta M R; Keene J D
Molecular biology of nuclear autoantigens.
Rheumatic diseases clinics of North America 1992;18(2):283-310.
1991: Tsai D E; Harper D S; Keene J D
U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts.
Nucleic acids research 1991;19(18):4931-6.
1991: Kenan D J; Query C C; Keene J D
RNA recognition: towards identifying determinants of specificity.
Trends in biochemical sciences 1991;16(6):214-20.
1991: Bentley R C; Keene J D
Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein.
Molecular and cellular biology 1991;11(4):1829-39.
1991: St Clair E W; Kenan D; Burch J A; Keene J D; Pisetsky D S
Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1885-92.
1991: Hoffman D W; Query C C; Golden B L; White S W; Keene J D
RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2495-9.
1991: Fresco L D; Harper D S; Keene J D
Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions.
Molecular and cellular biology 1991;11(3):1578-89.
1991: Keene J D; Query C C
Nuclear RNA-binding proteins.
Progress in nucleic acid research and molecular biology 1991;41():179-202.
1990: Lutz-Freyermuth C; Query C C; Keene J D
Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6393-7.
1990: St Clair E W; Kenan D; Burch J A; Keene J D; Pisetsky D S
The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3868-76.
1990: St Clair E W; Query C C; Bentley R; Keene J D; Polisson R P; Allen N B; Caldwell D S; Rice J R; Cox C; Pisetsky D S
Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.
Clinical immunology and immunopathology 1990;54(2):266-80.
1990: St Clair E W; Burch J A; Ward M M; Keene J D; Pisetsky D S
Temporal correlation of antibody responses to different epitopes of the human La autoantigen.
The Journal of clinical investigation 1990;85(2):515-21.
1990: Kelekar A; Keene J D
Downregulation of RNA polymerase III transcription of the hY3 gene in vitro.
Molecular biology reports 1990;14(2-3):173-4.
1990: Harper D S; Fresco L D; Keene J D
Characterization of a Drosophila U snRNP RNA-binding protein.
Molecular biology reports 1990;14(2-3):163.
1989: Query C C; Bentley R C; Keene J D
A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component.
Molecular and cellular biology 1989;9(11):4872-81.
1989: Crone D E; Keene J D
Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins.
Journal of virology 1989;63(10):4172-80.
1989: Frielle D W; Kim P B; Keene J D
Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis.
Virology 1989;172(1):274-84.
1989: St Clair E W; Talal N; Moutsopoulos H M; Ballester A; Zerva L; Keene J D; Pisetsky D S
Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.
Journal of autoimmunity 1989;2(4):335-44.
1989: Keene J D
Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics.
Journal of autoimmunity 1989;2(4):329-34.
1989: Lutz-Freyermuth C; Keene J D;
The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs.
Molecular and cellular biology 1989;9(7):2975-82.
1989: Query C C; Bentley R C; Keene J D
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.
Cell 1989;57(1):89-101.
1988: Deutscher S L; Harley J B; Keene J D
Molecular analysis of the 60-kDa human Ro ribonucleoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9479-83.
1988: Chambers J C; Kenan D; Martin B J; Keene J D
Genomic structure and amino acid sequence domains of the human La autoantigen.
The Journal of biological chemistry 1988;263(34):18043-51.
1988: St Clair E W; Pisetsky D S; Reich C F; Keene J D
Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4173-80.
1988: Deutscher S L; Keene J D
A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3299-303.
1988: St Clair E W; Pisetsky D S; Reich C F; Chambers J C; Keene J D
Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen.
Arthritis and rheumatism 1988;31(4):506-14.
1987: Query C C; Keene J D
A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen.
Cell 1987;51(2):211-20.
1987: Fresco L D; Kurilla M G; Keene J D
Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus.
Molecular and cellular biology 1987;7(3):1148-55.
1985: Kole R; Fresco L D; Keene J D; Cohen P L; Eisenberg R A; Andrews P G
Alu RNA-protein complexes formed in vitro react with a novel lupus autoantibody.
The Journal of biological chemistry 1985;260(21):11781-6.
1985: Keene J D
Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression.
Microbiological sciences 1985;2(5):152-6.
1985: Chambers J C; Keene J D
Isolation and analysis of cDNA clones expressing human lupus La antigen.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(7):2115-9.
1983: Chambers J C; Kurilla M G; Keene J D
Association between the 7 S RNA and the lupus La protein varies among cell types.
The Journal of biological chemistry 1983;258(19):11438-41.

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