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William Keevil

Research Profile

Chemicals & Drugs

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Prion Diseases

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Surgical Instruments

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Publications

TOP 3
R Hervé; C William Keevil
Current limitations about the cleaning of luminal endoscopes.
M S Gião; C William Keevil
Hydrodynamic shear stress to remove Listeria monocytogenes biofilms from stainless steel and polytetrafluoroethylene surfaces.
S L Warnes; V Caves; C William Keevil
Mechanism of copper surface toxicity in Escherichia coli O157:H7 and Salmonella involves immediate membrane depolarization followed by slower rate of DNA destruction which differs from that observed for Gram-positive bacteria.

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All Publications

2013: R Hervé; C William Keevil
Current limitations about the cleaning of luminal endoscopes.
The Journal of hospital infection 2013;83(1):22-9.
2013: M S Gião; C William Keevil
Hydrodynamic shear stress to remove Listeria monocytogenes biofilms from stainless steel and polytetrafluoroethylene surfaces.
Journal of applied microbiology 2013;114(1):256-65.
2012: S L Warnes; V Caves; C William Keevil
Mechanism of copper surface toxicity in Escherichia coli O157:H7 and Salmonella involves immediate membrane depolarization followed by slower rate of DNA destruction which differs from that observed for Gram-positive bacteria.
Environmental microbiology 2012;14(7):1730-43.
2012: Sarah L Warnes; Callum J Highmore; C William Keevil
Horizontal transfer of antibiotic resistance genes on abiotic touch surfaces: implications for public health.
mBio 2012;3(6):.
2012: T J Secker; Q Zhao; Eric W Abel; K B Borisenko; R Hervé; C William Keevil
Doped diamond-like carbon coatings for surgical instruments reduce protein and prion-amyloid biofouling and improve subsequent cleaning.
Biofouling 2012;28(6):563-9.
2011: Nuno Azevedo; L Cerqueira; T Jardim; C William Keevil; fernando Rodrigues; Agostinho J Almeida; Catarina Almeida; Maria João Vieira
Application of flow cytometry for the identification of Staphylococcus epidermidis by peptide nucleic acid fluorescence in situ hybridization (PNA FISH) in blood samples.
Antonie van Leeuwenhoek 2011;100(3):463-70.
2011: S L Warnes; C William Keevil
Mechanism of copper surface toxicity in vancomycin-resistant enterococci following wet or dry surface contact.
Applied and environmental microbiology 2011;77(17):6049-59.
2011: Samuel L Collins; Rodolphe Hervé; C William Keevil; Jeremy P Blaydes; JS Webb
Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids.
PloS one 2011;6(12):e28123.
2011: Laura Cerqueira; Mário Dinis-Ribeiro; Ricardo M Fernandes; Rui M Ferreira; Ceu Figueiredo; C William Keevil; Nuno Azevedo; Fátima Carneiro; Maria João Vieira
PNA-FISH as a new diagnostic method for the determination of clarithromycin resistance of Helicobacter pylori.
BMC microbiology 2011;11():101.
2011: Catarina Almeida; Nuno Azevedo; Sílvio Santos; C William Keevil; Maria João Vieira
Discriminating multi-species populations in biofilms with peptide nucleic acid fluorescence in situ hybridization (PNA FISH).
PloS one 2011;6(3):e14786.
2011: Maria S Gião; Nuno Azevedo; Sandra A Wilks; Maria João Vieira; C William Keevil
Interaction of Legionella pneumophila and Helicobacter pylori with bacterial species isolated from drinking water biofilms.
BMC microbiology 2011;11():57.
2010: L Weaver; J O Noyce; Harold Michels; C William Keevil
Potential action of copper surfaces on meticillin-resistant Staphylococcus aureus.
Journal of applied microbiology 2010;109(6):2200-5.
2010: S L Warnes; S M Green; Harold Michels; C William Keevil
Biocidal efficacy of copper alloys against pathogenic enterococci involves degradation of genomic and plasmid DNAs.
Applied and environmental microbiology 2010;76(16):5390-401.
2010: R Hervé; T J Secker; C William Keevil
Current risk of iatrogenic Creutzfeld-Jakob disease in the UK: efficacy of available cleaning chemistries and reusability of neurosurgical instruments.
The Journal of hospital infection 2010;75(4):309-13.
2010: Catarina Almeida; Nuno Azevedo; R M Fernandes; C William Keevil; Maria João Vieira
Fluorescence in situ hybridization method using a peptide nucleic acid probe for identification of Salmonella spp. in a broad spectrum of samples.
Applied and environmental microbiology 2010;76(13):4476-85.
2010: R P Howlin; N Khammo; T Secker; G McDonnell; C William Keevil
Application of a fluorescent dual stain to assess decontamination of tissue protein and prion amyloid from surgical stainless steel during simulated washer-disinfector cycles.
The Journal of hospital infection 2010;75(1):66-71.
2010: M S Gião; Nuno Azevedo; Sandra A Wilks; Maria João Vieira; C William Keevil
Effect of chlorine on incorporation of Helicobacter pylori into drinking water biofilms.
Applied and environmental microbiology 2010;76(5):1669-73.
2009: M S Gião; S A Wilks; Nuno Azevedo; Maria João Vieira; C William Keevil
Validation of SYTO 9/propidium iodide uptake for rapid detection of viable but noncultivable Legionella pneumophila.
Microbial ecology 2009;58(1):56-62.
2009: Catarina Almeida; Nuno Azevedo; C Iversen; S Fanning; C William Keevil; Maria João Vieira
Development and application of a novel peptide nucleic acid probe for the specific detection of Cronobacter genomospecies (Enterobacter sakazakii) in powdered infant formula.
Applied and environmental microbiology 2009;75(9):2925-30.
2009: R Hervé; R Collin; HE Pinchin; T Secker; C William Keevil
A rapid dual staining procedure for the quantitative discrimination of prion amyloid from tissues reveals how interactions between amyloid and lipids in tissue homogenates may hinder the detection of prions.
Journal of microbiological methods 2009;77(1):90-7.
2009: Nuno Azevedo; Susana P Lopes; C William Keevil; Maria Olivia Pereira; Maria João Vieira
Time to "go large" on biofilm research: advantages of an omics approach.
Biotechnology letters 2009;31(4):477-85.
2009: M S Gião; Maria João Vieira; Sandra A Wilks; Nuno Azevedo; C William Keevil
Incorporation of natural uncultivable Legionella pneumophila into potable water biofilms provides a protective niche against chlorination stress.
Biofouling 2009;25(4):345-51.
2009: M S Gião; S A Wilks; Nuno Azevedo; Maria João Vieira; C William Keevil
Comparison between standard culture and peptide nucleic acid 16S rRNA hybridization quantification to study the influence of physico-chemical parameters on Legionella pneumophila survival in drinking water biofilms.
Biofouling 2009;25(4):343-51.
2009: M S Gião; S Wilks; Nuno Azevedo; Maria João Vieira; C William Keevil
Incorporation of natural uncultivable Legionella pneumophila into potable water biofilms provides a protective niche against chlorination stress.
Biofouling 2009;25(4):335-41.
2008: M S Gião; Nuno Azevedo; S A Wilks; Maria João Vieira; C William Keevil
Persistence of Helicobacter pylori in heterotrophic drinking-water biofilms.
Applied and environmental microbiology 2008;74(19):5898-904.
2008: J C Warner; S D Rothwell; C William Keevil
Use of episcopic differential interference contrast microscopy to identify bacterial biofilms on salad leaves and track colonization by Salmonella Thompson.
Environmental microbiology 2008;10(4):918-25.
2008: Nuno Azevedo; Catarina Almeida; I Fernandes; L Cerqueira; S Dias; C William Keevil; Maria João Vieira
Survival of gastric and enterohepatic Helicobacter spp. in water: implications for transmission.
Applied and environmental microbiology 2008;74(6):1805-11.
2008: L Weaver; Harold Michels; C William Keevil
Survival of Clostridium difficile on copper and steel: futuristic options for hospital hygiene.
The Journal of hospital infection 2008;68(2):145-51.
2008: Sherif B Abdel Ghani; Louise Weaver; Zidan H Zidan; Hussein M Ali; C William Keevil; Richard C D Brown
Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives.
Bioorganic & medicinal chemistry letters 2008;18(2):518-22.
2008: IP Lipscomb; Arinder K Sihota; C William Keevil
Comparison between visual analysis and microscope assessment of surgical instrument cleanliness from sterile service departments.
The Journal of hospital infection 2008;68(1):52-8.
2007: Talis Juhna; Dagne Birzniece; S Larsson; D Zulenkovs; A Sharipo; Nuno Azevedo; F Ménard-Szczebara; S Castagnet; C Féliers; C William Keevil
Detection of Escherichia coli in biofilms from pipe samples and coupons in drinking water distribution networks.
Applied and environmental microbiology 2007;73(22):7456-64.
2007: IP Lipscomb; R Hervé; K Harris; HE Pinchin; R Collin; C William Keevil
Amyloid-specific fluorophores for the rapid, sensitive in situ detection of prion contamination on surgical instruments.
The Journal of general virology 2007;88(Pt 9):2619-26.
2007: N Guimarães; Nuno Azevedo; Ceu Figueiredo; C William Keevil; Maria João Vieira
Development and application of a novel peptide nucleic acid probe for the specific detection of Helicobacter pylori in gastric biopsy specimens.
Journal of clinical microbiology 2007;45(9):3089-94.
2007: Nuno Azevedo; Catarina Almeida; L Cerqueira; S Dias; C William Keevil; Maria João Vieira
Coccoid form of Helicobacter pylori as a morphological manifestation of cell adaptation to the environment.
Applied and environmental microbiology 2007;73(10):3423-7.
2007: Markku Lehtola; Eila Torvinen; Jaana Kusnetsov; Tarja Pitkänen; Leena Maunula; Carl-Henrik von Bonsdorff; Pertti J Martikainen; Sandra A Wilks; C William Keevil; Ilkka T Miettinen
Survival of Mycobacterium avium, Legionella pneumophila, Escherichia coli, and caliciviruses in drinking water-associated biofilms grown under high-shear turbulent flow.
Applied and environmental microbiology 2007;73(9):2854-9.
2007: JO Noyce; Harold Michels; C William Keevil
Inactivation of influenza A virus on copper versus stainless steel surfaces.
Applied and environmental microbiology 2007;73(8):2748-50.
2007: Nuno Azevedo; N Guimarães; Ceu Figueiredo; C William Keevil; Maria João Vieira
A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity.
Critical reviews in microbiology 2007;33(3):157-69.
2007: S M Braganra; Nuno Azevedo; Lúcia Chaves Simões; C William Keevil; Maria João Vieira
Use of fluorescent in situ hybridisation for the visualisation of Helicobacter pylori in real drinking water biofilms.
Water science and technology : a journal of the International Association on Water Pollution Research 2007;55(8-9):387-93.
2007: Fang Z Zhang; Carol Wagstaff; Anne M Rae; Arinder K Sihota; C William Keevil; Steve D Rothwell; Graham J J Clarkson; Richard W Michelmore; María José Truco; Mark S Dixon; Gail Taylor
QTLs for shelf life in lettuce co-locate with those for leaf biophysical properties but not with those for leaf developmental traits.
Journal of experimental botany 2007;58(6):1433-49.
2007: IP Lipscomb; HE Pinchin; R Collin; C William Keevil
Effect of drying time, ambient temperature and pre-soaks on prion-infected tissue contamination levels on surgical stainless steel: concerns over prolonged transportation of instruments from theatre to central sterile service departments.
The Journal of hospital infection 2007;65(1):72-7.
2006: IP Lipscomb; HE Pinchin; R Collin; K Harris; C William Keevil
Are surgical stainless steel wires used for intracranial implantation of PrPsc a good model of iatrogenic transmission from contaminated surgical stainless steel instruments after cleaning?
The Journal of hospital infection 2006;64(4):339-43.
2006: IP Lipscomb; HE Pinchin; R Collin; K Harris; C William Keevil
The sensitivity of approved Ninhydrin and Biuret tests in the assessment of protein contamination on surgical steel as an aid to prevent iatrogenic prion transmission.
The Journal of hospital infection 2006;64(3):288-92.
2006: IP Lipscomb; Arinder K Sihota; C William Keevil
Comparative study of surgical instruments from sterile-service departments for presence of residual gram-negative endotoxin and proteinaceous deposits.
Journal of clinical microbiology 2006;44(10):3728-33.
2006: IP Lipscomb; Arinder K Sihota; C William Keevil
Diathermy forceps and pencils: reservoirs for protein and prion contamination?
The Journal of hospital infection 2006;64(2):193-4.
2006: Nuno Azevedo; AP Pacheco; C William Keevil; Maria João Vieira
Adhesion of water stressed Helicobacter pylori to abiotic surfaces.
Journal of applied microbiology 2006;101(3):718-24.
2006: Sandra A Wilks; Harold Michels; C William Keevil
Survival of Listeria monocytogenes Scott A on metal surfaces: implications for cross-contamination.
International journal of food microbiology 2006;111(2):93-8.
2006: Sandra A Wilks; C William Keevil
Targeting species-specific low-affinity 16S rRNA binding sites by using peptide nucleic acids for detection of Legionellae in biofilms.
Applied and environmental microbiology 2006;72(8):5453-62.
2006: JO Noyce; Harold Michels; C William Keevil
Potential use of copper surfaces to reduce survival of epidemic meticillin-resistant Staphylococcus aureus in the healthcare environment.
The Journal of hospital infection 2006;63(3):289-97.
2006: JO Noyce; Harold Michels; C William Keevil
Use of copper cast alloys to control Escherichia coli O157 cross-contamination during food processing.
Applied and environmental microbiology 2006;72(6):4239-44.
2006: Nuno Azevedo; A R Pinto; NM Reis; Maria João Vieira; C William Keevil
Shear stress, temperature, and inoculation concentration influence the adhesion of water-stressed Helicobacter pylori to stainless steel 304 and polypropylene.
Applied and environmental microbiology 2006;72(4):2936-41.
2006: IP Lipscomb; Arinder K Sihota; Michelle Sandra Botham; K L Harris; C William Keevil
Rapid method for the sensitive detection of protein contamination on surgical instruments.
The Journal of hospital infection 2006;62(2):141-8.
2006: Lúcia Chaves Simões; Nuno Azevedo; Alexandra Pacheco; C William Keevil; Maria João Vieira
Drinking water biofilm assessment of total and culturable bacteria under different operating conditions.
Biofouling 2006;22(1-2):91-9.
2006: Markku Lehtola; Eila Torvinen; Ilkka T Miettinen; C William Keevil
Fluorescence in situ hybridization using peptide nucleic acid probes for rapid detection of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis in potable-water biofilms.
Applied and environmental microbiology 2006;72(1):848-53.
2005: Sandra A Wilks; Harold Michels; C William Keevil
The survival of Escherichia coli O157 on a range of metal surfaces.
International journal of food microbiology 2005;105(3):445-54.
2005: Markku Lehtola; Christopher J Loades; C William Keevil
Advantages of peptide nucleic acid oligonucleotides for sensitive site directed 16S rRNA fluorescence in situ hybridization (FISH) detection of Campylobacter jejuni, Campylobacter coli and Campylobacter lari.
Journal of microbiological methods 2005;62(2):211-9.
2004: Nigel Horan; L Fletcher; S M Betmal; Sandra A Wilks; C William Keevil
Die-off of enteric bacterial pathogens during mesophilic anaerobic digestion.
Water research 2004;38(5):1113-20.
2004: C William Keevil
The physico-chemistry of biofilm-mediated pitting corrosion of copper pipe supplying potable water.
Water science and technology : a journal of the International Association on Water Pollution Research 2004;49(2):91-8.
2004: Nuno Azevedo; AP Pacheco; C William Keevil; Maria João Vieira
Nutrient shock and incubation atmosphere influence recovery of culturable Helicobacter pylori from water.
Applied and environmental microbiology 2004;70(1):490-3.
2003: Nuno Azevedo; Maria João Vieira; C William Keevil
Establishment of a continuous model system to study Helicobacter pylori survival in potable water biofilms.
Water science and technology : a journal of the International Association on Water Pollution Research 2003;47(5):155-60.
2003: C William Keevil
Rapid detection of biofilms and adherent pathogens using scanning confocal laser microscopy and episcopic differential interference contrast microscopy.
Water science and technology : a journal of the International Association on Water Pollution Research 2003;47(5):105-16.
2001: C William Keevil
Continuous culture models to study pathogens in biofilms.
Methods in enzymology 2001;337():104-22.