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Astrid Kehlen

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Holger Cynis; Masato Fujii; Monique Haegele; Ulrich Heiser; Torsten Hoffmann; Astrid Kehlen; Stephan Schilling; Yuichiro Shibazaki; Hiroyuki Yoneyama; Hans-Ulrich Demuth
Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.
Astrid Kehlen; Thomas Klonisch; Katja Menge; Kathrin Gans; Monique Haegele; Cuong Hoang-Vu; Uta-Dorothee Immel; Hans-Ulrich Demuth
Role of glutaminyl cyclases in thyroid carcinomas.
Holger Cynis; Margreet R De Vries; Sabine Berg; Rico Eichentopf; Ernst-Joachim Freyse; Daniel Friedrich; Kathrin Gans; Sigrid Graubner; Monique Haegele; Ulrich Heiser; Isabel Hesse; Torsten Hoffmann; Wolfgang Jagla; Astrid Kehlen; Martin Kleinschmidt; Anke Müller; Paul H A Quax; Jens-Ulrich Rahfeld; Stephan Schilling; Reinhard Sedlmeier; Franziska Seifert; Anett Stephan; Daniela Trautwein; Michael Wermann; Raik Wolf; Ulrich Wollert; Hans-Ulrich Demuth
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

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All Publications

2013: Holger Cynis; Masato Fujii; Monique Haegele; Ulrich Heiser; Torsten Hoffmann; Astrid Kehlen; Stephan Schilling; Yuichiro Shibazaki; Hiroyuki Yoneyama; Hans-Ulrich Demuth
Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.
International journal of experimental pathology 2013;94(3):217-25.
2013: Astrid Kehlen; Thomas Klonisch; Katja Menge; Kathrin Gans; Monique Haegele; Cuong Hoang-Vu; Uta-Dorothee Immel; Hans-Ulrich Demuth
Role of glutaminyl cyclases in thyroid carcinomas.
Endocrine-related cancer 2013;20(1):79-90.
2011: Holger Cynis; Margreet R De Vries; Sabine Berg; Rico Eichentopf; Ernst-Joachim Freyse; Daniel Friedrich; Kathrin Gans; Sigrid Graubner; Monique Haegele; Ulrich Heiser; Isabel Hesse; Torsten Hoffmann; Wolfgang Jagla; Astrid Kehlen; Martin Kleinschmidt; Anke Müller; Paul H A Quax; Jens-Ulrich Rahfeld; Stephan Schilling; Reinhard Sedlmeier; Franziska Seifert; Anett Stephan; Daniela Trautwein; Michael Wermann; Raik Wolf; Ulrich Wollert; Hans-Ulrich Demuth
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
EMBO molecular medicine 2011;3(9):545-58.
2011: Cornelia Willing; Marco Peich; Adrian Danescu; Astrid Kehlen; Paul Fowler; Sabine Hombach-Klonisch
Estrogen-independent actions of environmentally relevant AhR-agonists in human endometrial epithelial cells.
Molecular human reproduction 2011;17(2):115-26.
2011: Ingo Schulz; Ulrike Zeitschel; Claudia Engel; Astrid Kehlen; Katja Menge; Antje Meyer; André J Niestroj; Steffen Rossner; Hans-Ulrich Demuth
Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway.
Journal of neuroinflammation 2011;8():86.
2010: Yvonne Radestock; Cornelia Willing; Astrid Kehlen; Cuong Hoang-Vu; Sabine Hombach-Klonisch
Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts.
Molecular cancer research : MCR 2010;8(4):494-506.
2010: Torsten Geissler; Wolfgang Brandt; Andrea Porzel; Dagmar Schlenzig; Astrid Kehlen; Ludger Wessjohann; Norbert Arnold
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Bioorganic & medicinal chemistry 2010;18(6):2173-7.
2009: J Schade; A Schmiedl; Astrid Kehlen; Tibor Veres; Michael Stephan; Reinhard Pabst; Stephan von Hörsten
Airway-specific recruitment of T cells is reduced in a CD26-deficient F344 rat substrain.
Clinical and experimental immunology 2009;158(1):133-42.
2008: Stephan Schilling; Ulrike Zeitschel; Torsten Hoffmann; Ulrich Heiser; Mike Francke; Astrid Kehlen; Max Holzer; Birgit Hutter-Paier; Manuela Prokesch; Manfred Windisch; Wolfgang Jagla; Dagmar Schlenzig; Christiane Lindner; Thomas Rudolph; Gunter Reuter; Holger Cynis; Dirk Montag; Hans-Ulrich Demuth; Steffen Rossner
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Nature medicine 2008;14(10):1106-11.
2008: Aleksandra Glogowska; Janette Pyka; Astrid Kehlen; Marek Los; Paul Perumal; Ekkehard Weber; Sheue-Yann Cheng; Cuong Hoang-Vu; Thomas Klonisch
The cytoplasmic domain of proEGF negatively regulates motility and elastinolytic activity in thyroid carcinoma cells.
Neoplasia (New York, N.Y.) 2008;10(10):1120-30.
2008: Ulf Forssmann; Carsten Stoetzer; Michael Stephan; Carsten Kruschinski; Thomas Skripuletz; Jutta Schade; Andreas Schmiedl; Reinhard Pabst; Leona Wagner; Torsten Hoffmann; Astrid Kehlen; Sylvia E Escher; Wolf-Georg Forssmann; Jörn Elsner; Stephan von Hörsten
Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1120-7.
2008: Holger Cynis; Jens-Ulrich Rahfeld; Anett Stephan; Astrid Kehlen; Birgit Koch; Michael Wermann; Hans-Ulrich Demuth; Stephan Schilling
Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.
Journal of molecular biology 2008;379(5):966-80.
2008: Anja Seifert; Thomas Klonisch; Jens Wulfaenger; Friedrich Haag; Henning Dralle; Jürgen Langner; Cuong Hoang-Vu; Astrid Kehlen
The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells.
Oncology reports 2008;19(6):1485-91.
2007: Helge Taubert; Peter Würl; T Greither; Matthias Kappler; Matthias Bache; Frank Bartel; Astrid Kehlen; Christine Lautenschläger; Linda C Harris; D Kaushal; Susanne Füssel; Axel Meye; Anja Böhnke; Hannelore Schmidt; Hans-Jürgen Holzhausen; Steffen Hauptmann
Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients.
Oncogene 2007;26(50):7170-4.
2007: Mabruk Erhuma; Martin Köbel; Tarek Mustafa; Jens Wulfänger; Henning Dralle; Cuong Hoang-Vu; Jürgen Langner; Barbara Seliger; Astrid Kehlen
Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues.
International journal of cancer. Journal international du cancer 2007;120(11):2393-400.
2007: Helge Taubert; T Greither; D Kaushal; Peter Würl; Matthias Bache; Frank Bartel; Astrid Kehlen; Christine Lautenschläger; L Harris; Kai Kraemer; Axel Meye; Matthias Kappler; Hannelore Schmidt; Hans-Jürgen Holzhausen; Steffen Hauptmann
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma.
Oncogene 2007;26(7):1098-100.
2006: Michael Klintschar; Uta-Dorothee Immel; Astrid Kehlen; Patrizia Schwaiger; Tarek Mustafa; Sebastian Mannweiler; Sigrid Regauer; Manfred Kleiber; Cuong Hoang-Vu
Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(2):237-41.
2005: Thomas Klonisch; Harald Müller-Huesmann; Maria Riedel; Astrid Kehlen; Joanna Bialek; Yvonne Radestock; Hans-Jürgen Holzhausen; Klaus Steger; Martin Ludwig; Wolfgang Weidner; Cuong Hoang-Vu; Sabine Hombach-Klonisch
INSL3 in the benign hyperplastic and neoplastic human prostate gland.
International journal of oncology 2005;27(2):307-15.
2005: Maria Strunnikova; Undraga Schagdarsurengin; Astrid Kehlen; James C Garbe; Martha R Stampfer; Reinhard Dammann
Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter.
Molecular and cellular biology 2005;25(10):3923-33.
2005: Sabine Hombach-Klonisch; Astrid Kehlen; Paul Fowler; Berthold Huppertz; J F Jugert; G Bischoff; E Schlüter; Jörg Buchmann; Thomas Klonisch
Regulation of functional steroid receptors and ligand-induced responses in telomerase-immortalized human endometrial epithelial cells.
Journal of molecular endocrinology 2005;34(2):517-34.
2005: Tarek Mustafa; Alexander Eckert; Thomas Klonisch; Astrid Kehlen; Peter Maurer; Michael Klintschar; Mabruk Erhuma; Robby Zschoyan; Oliver Gimm; Henning Dralle; Johannes Schubert; Cuong Hoang-Vu
Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):108-19.
2004: Zhouxun Chen; Tarek Mustafa; Bogusz Trojanowicz; Michael Brauckhoff; Oliver Gimm; Cornelia Schmutzler; Josef Köhrle; Hans-Jürgen Holzhausen; Astrid Kehlen; Thomas Klonisch; Rainer Finke; Henning Dralle; Cuong Hoang-Vu
CD82, and CD63 in thyroid cancer.
International journal of molecular medicine 2004;14(4):517-27.
2004: Sabine Hombach-Klonisch; Jennifer Schön; Astrid Kehlen; Steffen Blottner; Thomas Klonisch
Seasonal expression of INSL3 and Lgr8/Insl3 receptor transcripts indicates variable differentiation of Leydig cells in the roe deer testis.
Biology of reproduction 2004;71(4):1079-87.
2004: Astrid Kehlen; M Geisler; J Olsen; A Sablotzki; Jürgen Langner; Dagmar Riemann
IL-10 and TGF-beta differ in their regulation of aminopeptidase N/CD13 expression in monocytes.
International journal of molecular medicine 2004;13(6):877-82.
2004: Astrid Kehlen; Nadine Englert; Anja Seifert; Thomas Klonisch; Henning Dralle; Jürgen Langner; Cuong Hoang-Vu
Expression, regulation and function of autotaxin in thyroid carcinomas.
International journal of cancer. Journal international du cancer 2004;109(6):833-8.
2004: Tarek Mustafa; Thomas Klonisch; Sabine Hombach-Klonisch; Astrid Kehlen; Cornelia Schmutzler; Josef Koehrle; Oliver Gimm; Henning Dralle; Cuong Hoang-Vu
Expression of CD97 and CD55 in human medullary thyroid carcinomas.
International journal of oncology 2004;24(2):285-94.
2003: Astrid Kehlen; Uwe Lendeckel; Henning Dralle; Jürgen Langner; Cuong Hoang-Vu
Biological significance of aminopeptidase N/CD13 in thyroid carcinomas.
Cancer research 2003;63(23):8500-6.
2003: Kristin Recker; Thomas Klapperstück; Astrid Kehlen; Johannes Wohlrab
The importance of cationic amino acid transporter expression in human skin.
The Journal of investigative dermatology 2003;121(6):1552-3.
2003: Thomas Klonisch; Klaus Steger; Astrid Kehlen; William R Allen; Christine Froehlich; Johannes Kauffold; Martin Bergmann; Sabine Hombach-Klonisch
INSL3 ligand-receptor system in the equine testis.
Biology of reproduction 2003;68(6):1975-81.
2003: Sabine Hombach-Klonisch; Cuong Hoang-Vu; Astrid Kehlen; Raoul Hinze; Hans-Jürgen Holzhausen; Ekkehard Weber; Bernd Fischer; Henning Dralle; Thomas Klonisch
INSL-3 is expressed in human hyperplastic and neoplastic thyrocytes.
International journal of oncology 2003;22(5):993-1001.
2003: Astrid Kehlen; A Pachnio; K Thiele; Jürgen Langner
Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6.
Arthritis research & therapy 2003;5(4):R186-92.
2002: Helge Taubert; Dagmar Riemann; Astrid Kehlen; Axel Meye; Frank Bartel; V John; J Brandt; Matthias Bache; Peter Würl; H Schmidt; Ekkehard Weber
Expression of cathepsin B, D and L protein in juvenile idiopathic arthritis.
Autoimmunity 2002;35(3):221-4.
2002: Astrid Kehlen; K Thiele; Dagmar Riemann; Jürgen Langner
Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis.
Clinical and experimental immunology 2002;127(3):539-46.
2001: Astrid Kehlen; I Egbert; K Thiele; K Fischer; Dagmar Riemann; Jürgen Langner
Increased expression of interleukin-8 and aminopeptidase N by cell-cell contact: interleukin-8 is resistant to degradation by aminopeptidase N/CD13.
European cytokine network 2001;12(2):316-24.
2001: Dagmar Riemann; Gert H Hansen; Lise-Lotte Niels-Christiansen; E Thorsen; Lissi Immerdal; AN Santos; Astrid Kehlen; Jürgen Langner; E Michael Danielsen
Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains.
The Biochemical journal 2001;354(Pt 1):47-55.
2001: Astrid Kehlen; R Lauterbach; AN Santos; K Thiele; U Kabisch; E Weber; Dagmar Riemann; Jürgen Langner
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA).
Clinical and experimental immunology 2001;123(1):147-54.
2000: Astrid Kehlen; J Olsen; Jürgen Langner; D Riemann
Increased lymphocytic aminopeptidase N/CD13 promoter activity after cell-cell contact.
Journal of cellular biochemistry 2000;80(1):115-23.
2000: K Thiele; Dagmar Riemann; Alexander Navarrete Santos; Jürgen Langner; Astrid Kehlen
Cell-cell contact of human T cells with fibroblasts changes lymphocytic mRNA expression: increased mRNA expression of interleukin-17 and interleukin-17 receptor.
European cytokine network 2000;11(1):53-8.
2000: Dagmar Riemann; J Röntsch; B Hause; Jürgen Langner; Astrid Kehlen
Cell-cell contact between lymphocytes and fibroblast-like synoviocytes induces lymphocytic expression of aminopeptidase N/CD13 and results in lymphocytic activation.
Advances in experimental medicine and biology 2000;477():57-66.
2000: Astrid Kehlen; Jürgen Langner; Dagmar Riemann
Transforming growth factor-beta increases the expression of aminopeptidase N/CD13 mRNA and protein in monocytes and monocytic cell lines.
Advances in experimental medicine and biology 2000;477():49-56.
1999: Astrid Kehlen; K Thiele; Dagmar Riemann; N Rainov; Jürgen Langner
Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines.
Journal of neuroimmunology 1999;101(1):1-6.
1999: Dagmar Riemann; Astrid Kehlen; Jürgen Langner
CD13--not just a marker in leukemia typing.
Immunology today 1999;20(2):83-8.
1998: Alexander Navarrete Santos; Astrid Kehlen; W Schütte; Jürgen Langner; Dagmar Riemann
Regulation by transforming growth factor-beta1 of class II mRNA and protein expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
International immunology 1998;10(5):601-7.
1998: Astrid Kehlen; B Göhring; Jürgen Langner; Dagmar Riemann
Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators.
Clinical and experimental immunology 1998;111(2):435-41.
1997: Alexander Navarrete Santos; Dagmar Riemann; K Thiele; Astrid Kehlen; A Navarrete Santos; Jürgen Langner
Constitutive expression of HLA class II mRNA in synovial fibroblast-like cells from patients with rheumatoid arthritis .
Immunology letters 1997;58(1):53-8.
1997: Dagmar Riemann; Astrid Kehlen; K Thiele; Matthias Löhn; Jürgen Langner
Induction of aminopeptidase N/CD13 on human lymphocytes after adhesion to fibroblast-like synoviocytes, endothelial cells, epithelial cells, and monocytes/macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3425-32.
1997: K Thiele; Dagmar Riemann; Astrid Kehlen; Matthias Löhn; L K Vogel; Jürgen Langner
Two transfected endothelial cell lines expressing high levels of membrane bound or soluble aminopeptidase N.
Advances in experimental medicine and biology 1997;421():81-4.
1997: Dagmar Riemann; Astrid Kehlen; K Thiele; Matthias Löhn; Jürgen Langner
Co-incubation of lymphocytes with fibroblast-like synoviocytes and other cell types can induce lymphocytic surface expression of aminopeptidase N/CD13.
Advances in experimental medicine and biology 1997;421():75-9.
1996: A N Santos; D Riemann; A N Santos; Astrid Kehlen; K Thiele; Jürgen Langner
Treatment of fibroblast-like synoviocytes with IFN-gamma results in the down-regulation of autotaxin mRNA.
Biochemical and biophysical research communications 1996;229(2):419-24.
1995: Dagmar Riemann; Astrid Kehlen; Jürgen Langner
Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13.
Clinical and experimental immunology 1995;100(2):277-83.
1994: A Schwachula; Dagmar Riemann; Astrid Kehlen; Jürgen Langner
Characterization of the immunophenotype and functional properties of fibroblast-like synoviocytes in comparison to skin fibroblasts and umbilical vein endothelial cells.
Immunobiology 1994;190(1-2):67-92.