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Brian Keith

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TOP 3
Nicolas Skuli; Arjun G Yodh; Brian Keith; Meeri N Kim; Bryan L Krock; Jiaming Liang; Liping Liu; Amar J Majmundar; Lijoy K Mathew; Rickson C Mesquita; Zachary L Quinn; Anja Runge; Steven Schenkel; M Celeste Simon
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes.
Jolly Mazumdar; Michele M Hickey; Dhruv K Pant; Amy C Durham; Alejandro Sweet-Cordero; Anil Vachani; Tyler Jacks; Lewis A Chodosh; Joseph L Kissil; M Celeste Simon; Brian Keith
HIF-2alpha deletion promotes Kras-driven lung tumor development.
Jessica A Bertout; Amar J Majmundar; John D Gordan; Jennifer C Lam; Dara Ditsworth; Brian Keith; Eric J Brown; Katherine L Nathanson; M Celeste Simon
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.

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All Publications

2012: Nicolas Skuli; Arjun G Yodh; Brian Keith; Meeri N Kim; Bryan L Krock; Jiaming Liang; Liping Liu; Amar J Majmundar; Lijoy K Mathew; Rickson C Mesquita; Zachary L Quinn; Anja Runge; Steven Schenkel; M Celeste Simon
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes.
The Journal of clinical investigation 2012;122(4):1427-43.
2010: Jolly Mazumdar; Michele M Hickey; Dhruv K Pant; Amy C Durham; Alejandro Sweet-Cordero; Anil Vachani; Tyler Jacks; Lewis A Chodosh; Joseph L Kissil; M Celeste Simon; Brian Keith
HIF-2alpha deletion promotes Kras-driven lung tumor development.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14182-7.
2009: Jessica A Bertout; Amar J Majmundar; John D Gordan; Jennifer C Lam; Dara Ditsworth; Brian Keith; Eric J Brown; Katherine L Nathanson; M Celeste Simon
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14391-6.
2009: Erinn B Rankin; Jennifer Rha; Mary A Selak; Travis L Unger; Brian Keith; Qingdu Liu; Volker H Haase
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.
Molecular and cellular biology 2009;29(16):4527-38.
2009: Nicolas Skuli; Liping Liu; Anja Runge; Tao Wang; Lijun Yuan; Sunny Patel; Luisa Iruela-Arispe; M Celeste Simon; Brian Keith
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.
Blood 2009;114(2):469-77.
2008: John D Gordan; Priti Lal; Vijay R Dondeti; Richard Letrero; Krishna N Parekh; C Elisa Oquendo; Roger A. Greenberg; Keith T Flaherty; Wendy Rathmell; Brian Keith; M Celeste Simon; Katherine L Nathanson
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma.
Cancer cell 2008;14(6):435-46.
2008: Erinn B Rankin; Jennifer Rha; Travis L Unger; Chia H Wu; Heather P Shutt; Randall S Johnson; M Celeste Simon; Brian Keith; Volker H Haase
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.
Oncogene 2008;27(40):5354-8.
2008: Bryan C Barnhart; Jennifer C Lam; Regina M Young; Peter J Houghton; Brian Keith; M Celeste Simon
Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival.
Cancer biology & therapy 2008;7(9):1441-9.
2008: M Celeste Simon; Brian Keith
The role of oxygen availability in embryonic development and stem cell function.
Nature reviews. Molecular cell biology 2008;9(4):285-96.
2007: Brian Keith; M Celeste Simon
Hypoxia-inducible factors, stem cells, and cancer.
Cell 2007;129(3):465-72.
2007: Erinn B Rankin; Mangatt P Biju; Qingdu Liu; Travis L Unger; Jennifer Rha; Randall S Johnson; M Celeste Simon; Brian Keith; Volker H Haase
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
The Journal of clinical investigation 2007;117(4):1068-77.
2007: Michaela Gruber; Cheng-Jun Hu; Randall S Johnson; Eric J Brown; Brian Keith; M Celeste Simon
Acute postnatal ablation of Hif-2alpha results in anemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2301-6.
2006: Kelly L Covello; James Kehler; Hongwei Yu; John D Gordan; Andrew M Arsham; Cheng-Jun Hu; Patricia A Labosky; M Celeste Simon; Brian Keith
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
Genes & development 2006;20(5):557-70.
2006: Liping Liu; Timothy P Cash; Russell G Jones; Brian Keith; Craig Thompson; M Celeste Simon
Hypoxia-induced energy stress regulates mRNA translation and cell growth.
Molecular cell 2006;21(4):521-31.
2005: Kelly L Covello; M Celeste Simon; Brian Keith
Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.
Cancer research 2005;65(6):2277-86.
2003: Cheng-Jun Hu; Li-Yi Wang; Lewis A Chodosh; Brian Keith; M Celeste Simon
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Molecular and cellular biology 2003;23(24):9361-74.
2003: Fiona A Mack; Wendy Rathmell; Andrew M Arsham; James R Gnarra; Brian Keith; M Celeste Simon
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
Cancer cell 2003;3(1):75-88.
2001: Brian Keith; David M Adelman; M Celeste Simon
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6692-7.
2000: E Maltepe; Brian Keith; Andrew M Arsham; J R Brorson; M Celeste Simon
The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.
Biochemical and biophysical research communications 2000;273(1):231-8.