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John Keith

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Mark S Tichenor; Michael Webb; Michelle L Wennerholm; Sandy J Wilson; Filip Woestenborghs; Dominiek Beerens; Marlies De Boeck; Sean M Brown; Sandra R Chaplan; Natalie Hawryluk; William M Jones; Mark J Karbarz; John M Keith; Lin Luo; Jeff Merit; James A Palmer; Joan M Pierce; Mark Seierstad; J Guy Breitenbucher
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Michael A Letavic; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Mark A Feinstein; Ian C Fraser; Kenway Hoey; Xiaohui Jiang; John M Keith; Tatiana Koudriakova; Perry Leung; Brian Lord; Timothy W Lovenberg; Kiev S Ly; Kirsten L Morton; S Timothy Motley; Diane Nepomuceno; Michele Rizzolio; Raymond Rynberg; Kia Sepassi; Jonathan Shelton
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
John M Keith
One-step conversion of azine N-oxides to alpha-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes.

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All Publications

2012: Mark S Tichenor; Michael Webb; Michelle L Wennerholm; Sandy J Wilson; Filip Woestenborghs; Dominiek Beerens; Marlies De Boeck; Sean M Brown; Sandra R Chaplan; Natalie Hawryluk; William M Jones; Mark J Karbarz; John M Keith; Lin Luo; Jeff Merit; James A Palmer; Joan M Pierce; Mark Seierstad; J Guy Breitenbucher
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Bioorganic & medicinal chemistry letters 2012;22(24):7357-62.
2010: Michael A Letavic; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Mark A Feinstein; Ian C Fraser; Kenway Hoey; Xiaohui Jiang; John M Keith; Tatiana Koudriakova; Perry Leung; Brian Lord; Timothy W Lovenberg; Kiev S Ly; Kirsten L Morton; S Timothy Motley; Diane Nepomuceno; Michele Rizzolio; Raymond Rynberg; Kia Sepassi; Jonathan Shelton
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorganic & medicinal chemistry letters 2010;20(14):4210-4.
2010: John M Keith
One-step conversion of azine N-oxides to alpha-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes.
The Journal of organic chemistry 2010;75(8):2722-5.
2008: Michael A Letavic; John M Keith; Kiev S Ly; Pascal Bonaventure; Mark A Feinstein; Brian Lord; Kirsten L Miller; S Timothy Motley; Diane Nepomuceno; Steven W Sutton; Nicholas I Carruthers
2-Aryloxymethylmorpholine histamine H(3) antagonists.
Bioorganic & medicinal chemistry letters 2008;18(21):5796-9.
2008: John M Keith; Richard Apodaca; Wei Xiao; Mark Seierstad; Kanaka Pattabiraman; Jiejun Wu; Michael Webb; Mark J Karbarz; Sean Brown; Sandy Wilson; Brian Scott; Chui-Se Tham; Lin Luo; James Palmer; Michelle Wennerholm; Sandra Chaplan; J Guy Breitenbucher
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2008;18(17):4838-43.
2008: Scott D Bembenek; John M Keith; Michael A Letavic; Richard Apodaca; Ann J Barbier; Lisa Dvorak; Leah Aluisio; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Bioorganic & medicinal chemistry 2008;16(6):2968-73.
2008: John M Keith
One step conversion of heteroaromatic-N-oxides to imidazolo-heteroarenes.
The Journal of organic chemistry 2008;73(1):327-30.
2008: Kiev S Ly; Michael A Letavic; John M Keith; Jennifer M Miller; Emily M Stocking; Ann J Barbier; Pascal Bonaventure; Brian Lord; Xiaohui Jiang; Jamin D Boggs; Lisa Dvorak; Kirsten L Miller; Diane Nepomuceno; Sandy J Wilson; Nicholas I Carruthers
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):39-43.
2007: John M Keith; Ann J Barbier; Sandy J Wilson; Kirstin Miller; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.
Bioorganic & medicinal chemistry letters 2007;17(19):5325-9.
2007: John M Keith; Leslie A Gomez; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Brian Lord; Curt Mazur; Leah Aluisio; Timothy W Lovenberg; Nicholas I Carruthers
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(15):4374-7.
2007: John M Keith; Leslie A Gomez; Ronald L Wolin; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Curt Mazur; Ian C Fraser; Brian Lord; Leah Aluisio; Timothy W Lovenberg; Nicholas I Carruthers
Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2603-7.
2007: Michael A Letavic; John M Keith; Kiev S Ly; Ann J Barbier; Jamin D Boggs; Sandy J Wilson; Brian Lord; Timothy W Lovenberg; Nicholas I Carruthers
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2566-9.
2007: Michael A Letavic; John M Keith; JIll Jablonowski; Emily M Stocking; Leslie A Gomez; Kiev S Ly; Jennifer M Miller; Ann J Barbier; Pascal Bonaventure; Jamin D Boggs; Sandy J Wilson; Kirsten L Miller; Brian Lord; Heather M McAllister; D J Tognarelli; Jiejun Wu; Marta C Abad; Carsten Schubert; Timothy W Lovenberg; Nicholas I Carruthers
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(4):1047-51.
2007: John M Keith; Leslie A Gomez; Michael A Letavic; Kiev S Ly; JIll Jablonowski; Mark Seierstad; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Bioorganic & medicinal chemistry letters 2007;17(3):702-6.
2006: John M Keith
One-Step conversion of pyridine N-oxides to tetrazolo[1,5-a]pyridines.
The Journal of organic chemistry 2006;71(25):9540-3.
2006: John M Keith; Laurent Gomez
Exploration of the Mitsunobu reaction with Tosyl- and Boc-hydrazones as nucleophilic agents.
The Journal of organic chemistry 2006;71(18):7113-6.