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Ameeta Kelekar

Research Profile

Chemicals & Drugs

Physiology

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Publications

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Sonia G Das; David L Hermanson; Ameeta Kelekar; Yunfang Li; Xazmin Lowman; Nicholas Bleeker; Chengguo Xing
Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy.
Cecilia G Sanchez; Brian G Rowan; Aaron G Boonjindasup; David Z Cai; Santosh S Dhule; Ameeta Kelekar; Diane S Krause; Adam Z Oskowitz; Patrice Penfornis; Radhika R Pochampally
Activation of autophagy in mesenchymal stem cells provides tumor stromal support.
Xazmin H Lowman; Maureen A McDonnell; Ashley Kosloske; Oludare A Odumade; Christopher Jenness; Christine B Karim; Ronald Jemmerson; Ameeta Kelekar
The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.

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All Publications

2013: Sonia G Das; David L Hermanson; Ameeta Kelekar; Yunfang Li; Xazmin Lowman; Nicholas Bleeker; Chengguo Xing
Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy.
ACS chemical biology 2013;8(2):327-35.
2011: Cecilia G Sanchez; Brian G Rowan; Aaron G Boonjindasup; David Z Cai; Santosh S Dhule; Ameeta Kelekar; Diane S Krause; Adam Z Oskowitz; Patrice Penfornis; Radhika R Pochampally
Activation of autophagy in mesenchymal stem cells provides tumor stromal support.
Carcinogenesis 2011;32(7):964-72.
2010: Xazmin H Lowman; Maureen A McDonnell; Ashley Kosloske; Oludare A Odumade; Christopher Jenness; Christine B Karim; Ronald Jemmerson; Ameeta Kelekar
The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.
Molecular cell 2010;40(5):823-33.
2010: Duska Separovic; Ameeta Kelekar; Arun K Nayak; Adi L Tarca; Kentaro Hanada; Jason S Pierce; Jacek Bielawski
Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage.
Archives of biochemistry and biophysics 2010;494(1):101-5.
2010: Ramil Codina; Amelia Vanasse; Ameeta Kelekar; Vaiva Vezys; Ronald Jemmerson
Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1.
Apoptosis : an international journal on programmed cell death 2010;15(2):139-52.
2009: Tri Minh Bui Nguyen; Indira V Subramanian; Xue Xiao; Goutam Ghosh; Phan Nguyen; Ameeta Kelekar; Sundaram Ramakrishnan
Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels.
Journal of cellular and molecular medicine 2009;13(9B):3687-98.
2008: Maureen A McDonnell; Md Joynal Abedin; Manuel Melendez; Teodora N Platikanova; Johanna R Ecklund; Khalil Ahmed; Ameeta Kelekar
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.
The Journal of biological chemistry 2008;283(29):20149-58.
2008: Ameeta Kelekar
Introduction to the review series Autophagy in Higher Eukaryotes--a matter of survival or death.
Autophagy 2008;4(5):555-6.
2007: Sundaram Ramakrishnan; Tri Minh Bui Nguyen; Indira V Subramanian; Ameeta Kelekar
Autophagy and angiogenesis inhibition.
Autophagy 2007;3(5):512-5.
2007: Yuxing Zhao; Brian J Altman; Jonathan L Coloff; Catherine E Herman; Sarah R Jacobs; Heather L Wieman; Jessica A Wofford; Leah N DiMascio; Olga Ilkayeva; Ameeta Kelekar; Tannishtha Reya; Jeffrey C Rathmell
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.
Molecular and cellular biology 2007;27(12):4328-39.
2007: Tri Minh Bui Nguyen; Indira V Subramanian; Ameeta Kelekar; Sundaram Ramakrishnan
Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.
Blood 2007;109(11):4793-802.
2007: M J Abedin; D Wang; Maureen A McDonnell; U Lehmann; Ameeta Kelekar
Autophagy delays apoptotic death in breast cancer cells following DNA damage.
Cell death and differentiation 2007;14(3):500-10.
2005: Ameeta Kelekar
Autophagy.
Annals of the New York Academy of Sciences 2005;1066():259-71.
2005: Dehua Wang; Maureen A McDonnell; Ameeta Kelekar
Multi-probe RPA template sets to study RNA modulation and transcriptional control of BH3-only members of the Bcl-2 family.
Cancer detection and prevention 2005;29(2):189-200.
2004: Hengning Ke; Jing Pei; Zhenya Ni; Hong Xia; Huilin Qi; Tishonna Woods; Ameeta Kelekar; Wufan Tao
Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).
Experimental cell research 2004;298(2):329-38.
2003: Daniel A Vallera; Ni Jin; Yanqun Shu; Angela Panoskaltsis-Mortari; Ameeta Kelekar; Wei Chen
Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene.
Human gene therapy 2003;14(18):1787-98.
2003: Maureen A McDonnell; D Wang; S M Khan; Matthew G Vander Heiden; Ameeta Kelekar
Caspase-9 is activated in a cytochrome c-independent manner early during TNFalpha-induced apoptosis in murine cells.
Cell death and differentiation 2003;10(9):1005-15.
1999: BS Chang; Ameeta Kelekar; Marian H Harris; John Harlan; Stephen W Fesik; Craig Thompson
The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L).
Molecular and cellular biology 1999;19(10):6673-81.
1999: JC Pena; Ameeta Kelekar; Elaine Fuchs; Craig Thompson
Manipulation of outer root sheath cell survival perturbs the hair-growth cycle.
The EMBO journal 1999;18(13):3596-603.
1999: Andy J Minn; Claudia S Kettlun; H Liang; Ameeta Kelekar; Matthew G Vander Heiden; BS Chang; Stephen W Fesik; Michael Fill; Craig Thompson
Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms.
The EMBO journal 1999;18(3):632-43.
1998: Ameeta Kelekar; Craig Thompson
Bcl-2-family proteins: the role of the BH3 domain in apoptosis.
Trends in cell biology 1998;8(8):324-30.
1997: Ameeta Kelekar; BS Chang; John Harlan; Stephen W Fesik; Craig Thompson
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
Molecular and cellular biology 1997;17(12):7040-6.