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Barrie Kellam

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Leigh A Stoddart; Andrea J Vernall; Stephen J Briddon; Jessica L Denman; Barrie Kellam; Stephen J Hill
Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
Andrea J Vernall; Leigh A Stoddart; Stephen J Briddon; Stephen J Hill; Barrie Kellam
Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.
Jillian G Baker; Stephen J Hill; Richard J Middleton; Shailesh N Mistry; Karolina Salchow; Luke A Adams; Barrie Kellam
Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

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All Publications

2012: Leigh A Stoddart; Andrea J Vernall; Stephen J Briddon; Jessica L Denman; Barrie Kellam; Stephen J Hill
Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
Chemistry & biology 2012;19(9):1105-15.
2012: Andrea J Vernall; Leigh A Stoddart; Stephen J Briddon; Stephen J Hill; Barrie Kellam
Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.
Journal of medicinal chemistry 2012;55(4):1771-82.
2011: Jillian G Baker; Stephen J Hill; Richard J Middleton; Shailesh N Mistry; Karolina Salchow; Luke A Adams; Barrie Kellam
Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.
Journal of medicinal chemistry 2011;54(19):6874-87.
2011: Gopal P Jadhav; Siri Ram Chhabra; Gary Telford; Doreen S W Hooi; Karima Righetti; Paul Williams; Barrie Kellam; David I Pritchard; Peter M Fischer
Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone.
Journal of medicinal chemistry 2011;54(9):3348-59.
2011: Stephen J Briddon; Barrie Kellam; Stephen J Hill
Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells.
Methods in molecular biology (Clifton, N.J.) 2011;746():211-36.
2010: Jillian G Baker; Richard Middleton; Luke Adams; Lauren T May; Stephen J Briddon; Barrie Kellam; Stephen J Hill
Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.
British journal of pharmacology 2010;159(4):772-86.
2008: Yolande Cordeaux; Stephen J Briddon; S P H Alexander; Barrie Kellam; Stephen J Hill
Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):850-60.
2007: Paul A De Bank; Qingpu Hou; Robert M Warner; Ian V Wood; Bahaa E Ali; Sheila Macneil; David A Kendall; Barrie Kellam; Kevin M Shakesheff; Lee D K Buttery
Accelerated formation of multicellular 3-D structures by cell-to-cell cross-linking.
Biotechnology and bioengineering 2007;97(6):1617-25.
2007: Richard J Middleton; Stephen J Briddon; Yolande Cordeaux; Andrew S Yates; Clare L Dale; Michael W George; Jillian G Baker; Stephen J Hill; Barrie Kellam
New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.
Journal of medicinal chemistry 2007;50(4):782-93.
2005: Majed AbuKhader; John Heap; Cristina De Matteis; Barrie Kellam; Stephen W Doughty; Nigel P Minton; Max Paoli
Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.
Journal of medicinal chemistry 2005;48(24):7714-9.
2005: Richard J Middleton; Barrie Kellam
Fluorophore-tagged GPCR ligands.
Current opinion in chemical biology 2005;9(5):517-25.
2005: Andrew S Yates; Stephen W Doughty; David A Kendall; Barrie Kellam
Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.
Bioorganic & medicinal chemistry letters 2005;15(16):3758-62.
2004: Mark C Sleeman; Paul Smith; Barrie Kellam; Siri Ram Chhabra; Barrie W Bycroft; Christopher J Schofield
Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).
Chembiochem : a European journal of chemical biology 2004;5(6):879-82.
2004: Stephen J Briddon; Richard J Middleton; Yolande Cordeaux; F M Flavin; Julia A Weinstein; Michael W George; Barrie Kellam; Stephen J Hill
Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4673-8.
2004: Stephen J Briddon; Richard J Middleton; Andrew S Yates; Michael W George; Barrie Kellam; Stephen J Hill
Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level.
Faraday discussions 2004;126():197-207; discussion 245-54.
2003: Barrie Kellam; Paul A De Bank; Kevin M Shakesheff
Chemical modification of mammalian cell surfaces.
Chemical Society reviews 2003;32(6):327-37.
2003: Siri Ram Chhabra; Aisyah S Abdul Rahim; Barrie Kellam
Recent progress in the design of selectin inhibitors.
Mini reviews in medicinal chemistry 2003;3(7):679-87.
2003: Paul A De Bank; Barrie Kellam; David A Kendall; Kevin M Shakesheff
Surface engineering of living myoblasts via selective periodate oxidation.
Biotechnology and bioengineering 2003;81(7):800-8.
2003: Robin A Quirk; Barrie Kellam; Rena N Bhandari; Martyn C Davies; Saul J B Tendler; Kevin M Shakesheff
Cell-type-specific adhesion onto polymer surfaces from mixed cell populations.
Biotechnology and bioengineering 2003;81(5):625-8.