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Neil Kelleher

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Bradley S Evans; Courtney M Evans; Jiangtao Gao; Kou-San Ju; Neil L Kelleher; Wilfred Adrianus van der Donk; Changming Zhao; James R Doroghazi; William W Metcalf
Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection.
Michael Rothmann; Reymundo Villa; Eli Chapman; Minjin Kang; Neil L Kelleher; James J La Clair; Ioanna Ntai; Michael D Burkart
Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme a.
Xia Wu; Leonid Zamdborg; Steven C Huber; Neil L Kelleher; Adaikkalam Vellaichamy; Dongping Wang; Youfu Zhao
Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics.

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2013: Bradley S Evans; Courtney M Evans; Jiangtao Gao; Kou-San Ju; Neil L Kelleher; Wilfred Adrianus van der Donk; Changming Zhao; James R Doroghazi; William W Metcalf
Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection.
ACS chemical biology 2013;8(5):908-13.
2013: Michael Rothmann; Reymundo Villa; Eli Chapman; Minjin Kang; Neil L Kelleher; James J La Clair; Ioanna Ntai; Michael D Burkart
Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme a.
Journal of the American Chemical Society 2013;135(16):5962-5.
2013: Xia Wu; Leonid Zamdborg; Steven C Huber; Neil L Kelleher; Adaikkalam Vellaichamy; Dongping Wang; Youfu Zhao
Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics.
Journal of proteomics 2013;79():60-71.
2013: Adam D Catherman; Philip D Compton; Kenneth R Durbin; Bryan P Early; Mingxi Li; Paul M Thomas; John C Tran; Neil L Kelleher
Top down proteomics of human membrane proteins from enriched mitochondrial fractions.
Analytical chemistry 2013;85(3):1880-8.
2013: Ji Eun Lee; Mingxi Li; Jennifer W Mitchell; Bruce R Southey; Norman Atkins; Martha U Gillette; Neil L Kelleher; Leonid Zamdborg; Jonathan V Sweedler
Quantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus.
Journal of proteome research 2013;12(2):585-93.
2012: Chenxi Jia; Xiaoyue Jiang; Neil L Kelleher; Weifeng Cao; Adam D Catherman; Ruibing Chen; Ying Ge; Limei Hui; Christopher B Lietz; Paul M Thomas; Lingjun Li
High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides.
Molecular & cellular proteomics : MCP 2012;11(12):1951-64.
2012: Philip D Compton; Neil L Kelleher
Spinning up mass spectrometry for whole protein complexes.
Nature methods 2012;9(11):1065-6.
2012: Sungjin Park; Neil L Kelleher; Evgeniia Konishcheva; Ioanna Ntai; Paul Thomas; Alexander V Statsuk
Mechanism-based small molecule cross-linkers of HECT E3 ubiquitin ligase-substrate pairs.
Biochemistry 2012;51(42):8327-9.
2012: Neil L Kelleher
A cell-based approach to the human proteome project.
Journal of the American Society for Mass Spectrometry 2012;23(10):1617-24.
2012: Elena V Romanova; Jonathan V Sweedler; Neil L Kelleher; Ji Eun Lee; Joshua M Gulley
Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine.
Journal of neurochemistry 2012;123(2):276-87.
2012: Yupeng Zheng; Jonathan D Licht; Eva Martinez-Garcia; Relja Popovic; Steve M M Sweet; Paul M Thomas; Jeremiah D Tipton; Neil L Kelleher
Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13549-54.
2012: Dorothy R Ahlf; Philip D Compton; Bryan P Early; Paul M Thomas; John C Tran; Neil L Kelleher
Evaluation of the compact high-field orbitrap for top-down proteomics of human cells.
Journal of proteome research 2012;11(8):4308-14.
2012: Cong Wu; Leonid Zamdborg; Dorothy R Ahlf; Kenneth R Durbin; Bryan P Early; Mingxi Li; Jonathan V Sweedler; Paul M Thomas; John C Tran; Neil L Kelleher
A protease for 'middle-down' proteomics.
Nature methods 2012;9(8):822-4.
2012: Alexandre A Shvartsburg; Richard D Smith; Yupeng Zheng; Neil L Kelleher
Ion mobility separation of variant histone tails extending to the "middle-down" range.
Analytical chemistry 2012;84(10):4271-6.
2012: Anna L Vagstad; Katherine Belecki; Stefanie B Bumpus; Neil L Kelleher; Craig A Townsend
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.
Journal of the American Chemical Society 2012;134(15):6865-77.
2012: Jeremiah D Tipton; John C Tran; Dorothy R Ahlf; Adam D Catherman; Kenneth R Durbin; Christopher L Hendrickson; Neil L Kelleher; John F Kellie; Ji Eun Lee; Alan G Marshall
Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa.
Analytical chemistry 2012;84(5):2111-7.
2012: John F Kellie; Jeremy L Norris; Paul M Thomas; Jeremiah D Tipton; John C Tran; Chuck Witkowski; Adam D Catherman; Kenneth R Durbin; Neil L Kelleher
Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry.
Analytical chemistry 2012;84(1):209-15.
2012: Yunqiu Chen; James R Doroghazi; David P Labeda; Leonid Zamdborg; William W Metcalf; Sarah J Robinson; Kou-San Ju; Michelle Unger; Ioanna Ntai; Neil L Kelleher
A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria.
Journal of proteome research 2012;11(1):85-94.
2011: Katie J Molohon; Bradley S Evans; Kyle L Dunbar; Joel O Melby; Stefanie B Bumpus; Jaeheon Lee; Neil L Kelleher; Douglas A Mitchell
Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.
ACS chemical biology 2011;6(12):1307-13.
2011: John C Tran; Richard D LeDuc; Mingxi Li; Jeremiah D Tipton; Bryan P Early; Philip D Compton; Leonid Zamdborg; Adaikkalam Vellaichamy; Adam D Catherman; Nertila Siuti; Cong Wu; Paul M Thomas; Dorothy R Ahlf; Steve M M Sweet; John F Kellie; Kenneth R Durbin; Ji Eun Lee; Neil L Kelleher
Mapping intact protein isoforms in discovery mode using top-down proteomics.
Nature 2011;480(7376):254-8.
2011: Brian D Ames; Bradley S Evans; Xue Gao; Stuart W Haynes; Neil L Kelleher; Yi Tang; Christopher T Walsh
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.
Biochemistry 2011;50(40):8756-69.
2011: Philip D Compton; Paul M Thomas; Leonid Zamdborg; Neil L Kelleher
On the scalability and requirements of whole protein mass spectrometry.
Analytical chemistry 2011;83(17):6868-74.
2011: Wenjun Zhang; Neil L Kelleher; Ioanna Ntai; Christopher T Walsh
tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12249-53.
2011: Jeremiah D Tipton; John C Tran; Dorothy R Ahlf; Adam D Catherman; Kenneth R Durbin; Neil L Kelleher
Analysis of intact protein isoforms by mass spectrometry.
The Journal of biological chemistry 2011;286(29):25451-8.
2011: Bradley S Evans; Yunqiu Chen; William W Metcalf; Huimin Zhao; Neil L Kelleher
Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.
Chemistry & biology 2011;18(5):601-7.
2011: Bradley S Evans; Ioanna Ntai; Yunqiu Chen; Sarah J Robinson; Neil L Kelleher
Proteomics-based discovery of koranimine, a cyclic imine natural product.
Journal of the American Chemical Society 2011;133(19):7316-9.
2011: Marie A Hollenhorst; Ioanna Ntai; Bernard Badet; Neil L Kelleher; Christopher T Walsh
A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway.
Biochemistry 2011;50(19):3859-61.
2011: Wenjun Zhang; Ioanna Ntai; Megan L Bolla; Steven J Malcolmson; Daniel Kahne; Neil L Kelleher; Christopher T Walsh
Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics.
Journal of the American Chemical Society 2011;133(14):5240-3.
2011: Eva Martinez-Garcia; Relja Popovic; Dong-Joon Min; Steve Sweet; Paul M Thomas; Leonid Zamdborg; Aaron Heffner; Christine Will; Laurence Lamy; Louis M Staudt; David L Levens; Neil L Kelleher; Jonathan D Licht
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
Blood 2011;117(1):211-20.
2011: Bradley S Evans; Sarah J Robinson; Neil L Kelleher
Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo.
Fungal genetics and biology : FG & B 2011;48(1):49-61.
2010: Marie A Hollenhorst; Stefanie Bumpus; Megan L Matthews; J Martin Bollinger; Neil L Kelleher; Christopher T Walsh
The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.
Journal of the American Chemical Society 2010;132(44):15773-81.
2010: Steve Sweet; Mingxi Li; Paul M Thomas; Kenneth R Durbin; Neil L Kelleher
Kinetics of re-establishing H3K79 methylation marks in global human chromatin.
The Journal of biological chemistry 2010;285(43):32778-86.
2010: Kenneth R Durbin; John C Tran; Leonid Zamdborg; Steve Sweet; Adam D Catherman; Ji Eun Lee; Mingxi Li; John F Kellie; Neil L Kelleher
Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale.
Proteomics 2010;10(20):3589-97.
2010: John F Kellie; John C Tran; Ji Eun Lee; Dorothy R Ahlf; Haylee M Thomas; Ioanna Ntai; Adam D Catherman; Kenneth R Durbin; Leonid Zamdborg; Adaikkalam Vellaichamy; Paul M Thomas; Neil L Kelleher
The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput.
Molecular bioSystems 2010;6(9):1532-9.
2010: Elena V Romanova; Ji Eun Lee; Neil L Kelleher; Jonathan V Sweedler; Joshua M Gulley
Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine.
The AAPS journal 2010;12(3):443-54.
2010: Yupeng Zheng; Sam John; James J Pesavento; Jennifer R Schultz-Norton; R Louis Schiltz; Sonjoon Baek; Ann M Nardulli; Gordon L Hager; Neil L Kelleher; Craig A Mizzen
Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II.
The Journal of cell biology 2010;189(3):407-15.
2010: Adaikkalam Vellaichamy; John C Tran; Adam D Catherman; Ji Eun Lee; John F Kellie; Steve Sweet; Leonid Zamdborg; Paul M Thomas; Dorothy R Ahlf; Kenneth R Durbin; Gary A Valaskovic; Neil L Kelleher
Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa.
Analytical chemistry 2010;82(4):1234-44.
2010: Ji Eun Lee; Norman Atkins; Nathan G Hatcher; Leonid Zamdborg; Martha L Gillette; Jonathan V Sweedler; Neil L Kelleher
Endogenous peptide discovery of the rat circadian clock: a focused study of the suprachiasmatic nucleus by ultrahigh performance tandem mass spectrometry.
Molecular & cellular proteomics : MCP 2010;9(2):285-97.
2010: Tyler Johannes; Matthew A DeSieno; Benjamin M Griffin; Paul M Thomas; Neil L Kelleher; William W Metcalf; Huimin Zhao
Deciphering the late biosynthetic steps of antimalarial compound FR-900098.
Chemistry & biology 2010;17(1):57-64.
2010: Nertila Siuti; Neil L Kelleher
Efficient readout of posttranslational codes on the 50-residue tail of histone H3 by high-resolution MS/MS.
Analytical biochemistry 2010;396(2):180-7.
2009: Ji Eun Lee; John F Kellie; John C Tran; Jeremiah D Tipton; Adam D Catherman; Haylee M Thomas; Dorothy R Ahlf; Kenneth R Durbin; Adaikkalam Vellaichamy; Ioanna Ntai; Alan G Marshall; Neil L Kelleher
A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome.
Journal of the American Society for Mass Spectrometry 2009;20(12):2183-91.
2009: Mingxi Li; Lihua Jiang; Neil L Kelleher
Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(30):3885-92.
2009: Stefanie Bumpus; Bradley S Evans; Paul M Thomas; Ioanna Ntai; Neil L Kelleher
A proteomics approach to discovering natural products and their biosynthetic pathways.
Nature biotechnology 2009;27(10):951-6.
2009: M Violet Lee; Leigh Anne Furgerson Ihnken; Young Ok You; Amanda McClerren; Wilfred Adrianus van der Donk; Neil L Kelleher
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry.
Journal of the American Chemical Society 2009;131(34):12258-64.
2009: Jonathan T Ferguson; Craig D Wenger; William W Metcalf; Neil L Kelleher
Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans.
Journal of the American Society for Mass Spectrometry 2009;20(9):1743-50.
2009: Bradley S Evans; Neil L Kelleher
To cyclize or not to cyclize: catching enzyme evolution in the act.
ACS chemical biology 2009;4(7):495-7.
2009: Jin-Hee Lee; Bradley S Evans; Gongyong Li; Neil L Kelleher; Wilfred Adrianus van der Donk
In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis.
Biochemistry 2009;48(23):5054-6.
2009: Xiao-Dong Yang; Bo Huang; Mingxi Li; Acacia Lamb; Neil L Kelleher; Lin Feng Chen
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.
The EMBO journal 2009;28(8):1055-66.
2009: John A Kalaitzis; Qian Cheng; Paul M Thomas; Neil L Kelleher; Bradley S Moore
In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides.
Journal of natural products 2009;72(3):469-72.
2009: Michael Boyne II; Benjamin A Garcia; Mingxi Li; Leonid Zamdborg; Craig D Wenger; Shannee Babai; Neil L Kelleher
Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval.
Journal of proteome research 2009;8(1):374-9.
2008: Matthias Mann; Neil L Kelleher
Precision proteomics: the case for high resolution and high mass accuracy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18132-8.
2008: Craig D Wenger; Michael Boyne II; Jonathan T Ferguson; Dana E Robinson; Neil L Kelleher
Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra.
Analytical chemistry 2008;80(21):8055-63.
2008: Adriana Bora; Suresh Annangudi; Larry J Millet; Stanislav S Rubakhin; Andrew J Forbes; Neil L Kelleher; Martha L Gillette; Jonathan V Sweedler
Neuropeptidomics of the supraoptic rat nucleus.
Journal of proteome research 2008;7(11):4992-5003.
2008: Stefanie Bumpus; Neil L Kelleher
Accessing natural product biosynthetic processes by mass spectrometry.
Current opinion in chemical biology 2008;12(5):475-82.
2008: Benjamin A Garcia; C Eric Thomas; Neil L Kelleher; Craig A Mizzen
Tissue-specific expression and post-translational modification of histone H3 variants.
Journal of proteome research 2008;7(10):4225-36.
2008: Nathan A Magarvey; Pascal D Fortin; Paul M Thomas; Neil L Kelleher; Christopher T Walsh
Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.
ACS chemical biology 2008;3(9):542-54.
2008: Stefanie Bumpus; Nathan A Magarvey; Neil L Kelleher; Christopher T Walsh; Christopher T Calderone
Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis.
Journal of the American Chemical Society 2008;130(35):11614-6.
2008: Christopher T Calderone; Stefanie Bumpus; Neil L Kelleher; Christopher T Walsh; Nathan A Magarvey
A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12809-14.
2008: Nathan G Hatcher; Norman Atkins; Suresh Annangudi; Andrew J Forbes; Neil L Kelleher; Martha L Gillette; Jonathan V Sweedler
Mass spectrometry-based discovery of circadian peptides.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12527-32.
2008: Andrew C Eliot; Benjamin M Griffin; Paul M Thomas; Tyler Johannes; Neil L Kelleher; Huimin Zhao; William W Metcalf
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.
Chemistry & biology 2008;15(8):765-70.
2008: Jennifer S Brodbelt; Fred W McLafferty; Neil L Kelleher
Focus in honor of Roman Zubarev, recipient of the 2007 Biemann Medal.
Journal of the American Society for Mass Spectrometry 2008;19(6):751-2.
2008: James J Pesavento; Courtney R Bullock; Richard D LeDuc; Craig A Mizzen; Neil L Kelleher
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.
The Journal of biological chemistry 2008;283(22):14927-37.
2008: Hongbo Yang; James J Pesavento; Taylor W Starnes; Diane E Cryderman; Lori L Wallrath; Neil L Kelleher; Craig A Mizzen
Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
The Journal of biological chemistry 2008;283(18):12085-92.
2008: Michael J Roth; Bryan A Parks; Jonathan T Ferguson; Michael Boyne II; Neil L Kelleher
"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry.
Analytical chemistry 2008;80(8):2857-66.
2008: Jason M Crawford; Paul M Thomas; Jonathan R Scheerer; Anna L Vagstad; Neil L Kelleher; Craig A Townsend
Deconstruction of iterative multidomain polyketide synthase function.
Science (New York, N.Y.) 2008;320(5873):243-6.
2008: Ari M Frank; James J Pesavento; Craig A Mizzen; Neil L Kelleher; Pavel A Pevzner
Interpreting top-down mass spectra using spectral alignment.
Analytical chemistry 2008;80(7):2499-505.
2008: Jian Zhang; Steven G Van Lanen; Jianhua Ju; Wen Liu; Pieter dorrestein; Wenli Li; Neil L Kelleher; Ben Shen
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1460-5.
2008: Casey Krusemark; Jonathan T Ferguson; Craig D Wenger; Neil L Kelleher; Peter J Belshaw
Global amine and acid functional group modification of proteins.
Analytical chemistry 2008;80(3):713-20.
2008: James J Pesavento; Hongbo Yang; Neil L Kelleher; Craig A Mizzen
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle.
Molecular and cellular biology 2008;28(1):468-86.
2007: John Astle; Jonathan T Ferguson; Bruce german; George G Harrigan; Neil L Kelleher; Thomas Kodadek; Bryan A Parks; Michael J Roth; Keith W Singletary; Craig D Wenger; Gail B Mahady
Characterization of proteomic and metabolomic responses to dietary factors and supplements.
The Journal of nutrition 2007;137(12):2787-93.
2007: Bryan A Parks; Lihua Jiang; Paul M Thomas; Craig D Wenger; Michael J Roth; Michael Boyne II; Patricia V Burke; Kurt E Kwast; Neil L Kelleher
Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers.
Analytical chemistry 2007;79(21):7984-91.
2007: Nertila Siuti; Neil L Kelleher
Decoding protein modifications using top-down mass spectrometry.
Nature methods 2007;4(10):817-21.
2007: Lihua Jiang; Jonell N Smith; Shannon L Anderson; Ping Ma; Craig A Mizzen; Neil L Kelleher
Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail.
The Journal of biological chemistry 2007;282(38):27923-34.
2007: Richard D Leduc; Neil L Kelleher
Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data.
Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.] 2007;Chapter 13():Unit 13.6.
2007: James J Pesavento; Benjamin A Garcia; James A Streeky; Neil L Kelleher; Craig A Mizzen
Mild performic acid oxidation enhances chromatographic and top down mass spectrometric analyses of histones.
Molecular & cellular proteomics : MCP 2007;6(9):1510-26.
2007: Joshua A V Blodgett; Paul M Thomas; Gongyong Li; Juan E Velasquez; Wilfred Adrianus van der Donk; Neil L Kelleher; William W Metcalf
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
Nature chemical biology 2007;3(8):480-5.
2007: Christopher T Calderone; David F Iwig; Pieter dorrestein; Neil L Kelleher; Christopher T Walsh
Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.
Chemistry & biology 2007;14(7):835-46.
2007: Leonid Zamdborg; Richard D LeDuc; Kevin J Glowacz; Yong-Bin Kim; Vinayak Viswanathan; Ian T Spaulding; Bryan P Early; Eric J Bluhm; Shannee Babai; Neil L Kelleher
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry.
Nucleic acids research 2007;35(Web Server issue):W701-6.
2007: Benjamin A Garcia; James J Pesavento; Craig A Mizzen; Neil L Kelleher
Pervasive combinatorial modification of histone H3 in human cells.
Nature methods 2007;4(6):487-9.
2007: Darren B Hansen; Stefanie Bumpus; Zachary D Aron; Neil L Kelleher; Christopher T Walsh
The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity.
Journal of the American Chemical Society 2007;129(20):6366-7.
2007: Jun Yin; Paul D Straight; Sinisa Hrvatin; Pieter dorrestein; Stefanie Bumpus; Cindy Jao; Neil L Kelleher; Roberto Kolter; Christopher T Walsh
Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display.
Chemistry & biology 2007;14(3):303-12.
2007: Wendy Kelly; Michael Boyne II; Ellen Yeh; David A Vosburg; Danica P Galonić; Neil L Kelleher; Christopher T Walsh
Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.
Biochemistry 2007;46(2):359-68.
2007: John T Whitteck; Weijuan Ni; Benjamin M Griffin; Andrew C Eliot; Paul M Thomas; Neil L Kelleher; William W Metcalf; Wilfred Adrianus van der Donk
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid.
Angewandte Chemie (International ed. in English) 2007;46(47):9089-92.
2007: You Sang Hwang; Paul R Thompson; Ling Wang; Lihua Jiang; Neil L Kelleher; Philip A Cole
A selective chemical probe for coenzyme A-requiring enzymes.
Angewandte Chemie (International ed. in English) 2007;46(40):7621-4.
2006: Balasubramanyam Karanam; Lihua Jiang; Ling Wang; Neil L Kelleher; Philip A Cole
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation.
The Journal of biological chemistry 2006;281(52):40292-301.
2006: James Hemp; Dana E Robinson; Krithika B Ganesan; Todd J Martinez; Neil L Kelleher; Robert B Gennis
Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases.
Biochemistry 2006;45(51):15405-10.
2006: Pieter dorrestein; Neil L Kelleher
Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry.
Natural product reports 2006;23(6):893-918.
2006: Amanda McClerren; Lisa E Cooper; Chao Quan; Paul M Thomas; Neil L Kelleher; Wilfred Adrianus van der Donk
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17243-8.
2006: Ryan Woodyer; Zengyi Shao; Paul M Thomas; Neil L Kelleher; Joshua A V Blodgett; William W Metcalf; Wilfred Adrianus van der Donk; Huimin Zhao
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.
Chemistry & biology 2006;13(11):1171-82.
2006: Pieter dorrestein; Stefanie Bumpus; Christopher T Calderone; Sylvie Garneau-Tsodikova; Zachary D Aron; Paul D Straight; Roberto Kolter; Christopher T Walsh; Neil L Kelleher
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.
Biochemistry 2006;45(42):12756-66.
2006: Steven G Van Lanen; Shuangjun Lin; Pieter dorrestein; Neil L Kelleher; Ben Shen
Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
The Journal of biological chemistry 2006;281(40):29633-40.
2006: Sylvie Garneau-Tsodikova; Pieter dorrestein; Neil L Kelleher; Christopher T Walsh
Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.
Journal of the American Chemical Society 2006;128(39):12600-1.
2006: Leslie M Hicks; Carl J Balibar; Christopher T Walsh; Neil L Kelleher; Nathan J Hillson
Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry.
Biophysical journal 2006;91(7):2609-19.
2006: Yolande A Chan; Michael Boyne II; Angela M Podevels; Amy K Klimowicz; Jo Handelsman; Neil L Kelleher; Michael G Thomas
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14349-54.
2006: Benjamin A Garcia; Swati Joshi; C Eric Thomas; Raghu K Chitta; Robert L Diaz; Scott A Busby; Philip C Andrews; Rachel R Ogorzalek Loo; Jeffrey Shabanowitz; Neil L Kelleher; Craig A Mizzen; C David Allis; Donald F Hunt
Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila.
Molecular & cellular proteomics : MCP 2006;5(9):1593-609.
2006: Pieter dorrestein; Steven G Van Lanen; Wenli Li; Chunhua Zhao; Zixin Deng; Ben Shen; Neil L Kelleher
The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis.
Journal of the American Chemical Society 2006;128(32):10386-7.
2006: Elena V Romanova; Michael J Roth; Stanislav S Rubakhin; Jennifer A Jakubowski; Wayne P Kelley; Mark D Kirk; Neil L Kelleher; Jonathan V Sweedler
Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica.
Journal of mass spectrometry : JMS 2006;41(8):1030-40.
2006: James J Pesavento; Craig A Mizzen; Neil L Kelleher
Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.
Analytical chemistry 2006;78(13):4271-80.
2006: Christopher T Calderone; Walter Kowtoniuk; Neil L Kelleher; Christopher T Walsh; Pieter dorrestein
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):8977-82.
2006: Leslie M Hicks; Matthew T Mazur; Leah M. Miller; Pieter dorrestein; Nathan A Schnarr; Chaitan Khosla; Neil L Kelleher
Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry.
Chembiochem : a European journal of chemical biology 2006;7(6):904-7.
2006: Mark Howarth; Daniel J-F Chinnapen; Kimberly Gerrow; Pieter dorrestein; Melanie R Grandy; Neil L Kelleher; Alaa El-Husseini; Alice Y Ting
A monovalent streptavidin with a single femtomolar biotin binding site.
Nature methods 2006;3(4):267-73.
2006: Gregory J Gatto; Michael Boyne II; Neil L Kelleher; Christopher T Walsh
Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster.
Journal of the American Chemical Society 2006;128(11):3838-47.
2006: Leslie M Hicks; Michelle C Moffitt; Laura L Beer; Bradley S Moore; Neil L Kelleher
Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase.
ACS chemical biology 2006;1(2):93-102.
2006: Pieter dorrestein; Jonathan Blackhall; Paul D Straight; Michael A Fischbach; Sylvie Garneau-Tsodikova; Daniel J Edwards; Shaun McLaughlin; Myat Lin; William H Gerwick; Roberto Kolter; Christopher T Walsh; Neil L Kelleher
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry.
Biochemistry 2006;45(6):1537-46.
2006: Leah M. Miller; Champak Chatterjee; Wilfred Adrianus van der Donk; Neil L Kelleher
The dehydratase activity of lacticin 481 synthetase is highly processive.
Journal of the American Chemical Society 2006;128(5):1420-1.
2006: Michael Boyne II; James J Pesavento; Craig A Mizzen; Neil L Kelleher
Precise characterization of human histones in the H2A gene family by top down mass spectrometry.
Journal of proteome research 2006;5(2):248-53.
2006: C Eric Thomas; Neil L Kelleher; Craig A Mizzen
Mass spectrometric characterization of human histone H3: a bird's eye view.
Journal of proteome research 2006;5(2):240-7.
2006: Nertila Siuti; Michael J Roth; Craig A Mizzen; Neil L Kelleher; James J Pesavento
Gene-specific characterization of human histone H2B by electron capture dissociation.
Journal of proteome research 2006;5(2):233-9.
2006: try ty; Bryan A Parks; Seyoung Sohn; Kurt E Kwast; Neil L Kelleher
Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry.
Analytical chemistry 2006;78(3):686-94.
2006: Zhen Zhang; Xiuxiang An; Kui Yang; Deborah L Perlstein; Leslie Hicks; Neil L Kelleher; JoAnne Stubbe; Mingxia Huang
Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1422-7.
2006: Steven M Patrie; Jonathan T Ferguson; Dana E Robinson; Dave Whipple; Michael Rother; William W Metcalf; Neil L Kelleher
Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation.
Molecular & cellular proteomics : MCP 2006;5(1):14-25.
2005: Vlad Zabrouskov; Michael W Senko; Yi Du; Richard D Leduc; Neil L Kelleher
New and automated MSn approaches for top-down identification of modified proteins.
Journal of the American Society for Mass Spectrometry 2005;16(12):2027-38.
2005: Champak Chatterjee; Leah M. Miller; Yong L Leung; Lili Xie; Myongsin Yi; Neil L Kelleher; Wilfred Adrianus van der Donk
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production.
Journal of the American Chemical Society 2005;127(44):15332-3.
2005: Zachary D Aron; Pieter dorrestein; Jonathan R Blackhall; Neil L Kelleher; Christopher T Walsh
Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster.
Journal of the American Chemical Society 2005;127(43):14986-7.
2005: Shaun M McLoughlin; Neil L Kelleher
Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly.
Journal of the American Chemical Society 2005;127(43):14984-5.
2005: Shaun M McLoughlin; Matthew T Mazur; Leah M. Miller; Jun Yin; Fei Liu; Christopher T Walsh; Neil L Kelleher
Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry.
Biochemistry 2005;44(43):14159-69.
2005: Jun Yin; Paul D Straight; Shaun M McLoughlin; Zhe Zhou; Alison J Lin; David E Golan; Neil L Kelleher; Roberto Kolter; Christopher T Walsh
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15815-20.
2005: Leah M. Miller; Matthew T Mazur; Shaun M McLoughlin; Neil L Kelleher
Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry.
Protein science : a publication of the Protein Society 2005;14(10):2702-12.
2005: Neil L Kelleher; Leslie M Hicks
Contemporary mass spectrometry for the direct detection of enzyme intermediates.
Current opinion in chemical biology 2005;9(5):424-30.
2005: Pieter dorrestein; Ellen Yeh; Sylvie Garneau-Tsodikova; Neil L Kelleher; Christopher T Walsh
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13843-8.
2005: Steven G Van Lanen; Pieter dorrestein; Steven D Christenson; Wen Liu; Jianhua Ju; Neil L Kelleher; Ben Shen
Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates.
Journal of the American Chemical Society 2005;127(33):11594-5.
2005: Brenda A Frankel; Ryan G Kruger; Dana E Robinson; Neil L Kelleher; Dewey G McCafferty
Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism.
Biochemistry 2005;44(33):11188-200.
2005: Michael J Roth; Andrew J Forbes; Michael Boyne II; Yong-Bin Kim; Dana E Robinson; Neil L Kelleher
Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry.
Molecular & cellular proteomics : MCP 2005;4(7):1002-8.
2005: Gregory J Gatto; Shaun M McLoughlin; Neil L Kelleher; Christopher T Walsh
Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.
Biochemistry 2005;44(16):5993-6002.
2005: Sylvie Garneau; Pieter dorrestein; Neil L Kelleher; Christopher T Walsh
Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis.
Biochemistry 2005;44(8):2770-80.
2005: Fanyu Meng; Andrew J Forbes; Leah M. Miller; Neil L Kelleher
Detection and localization of protein modifications by high resolution tandem mass spectrometry.
Mass spectrometry reviews 2005;24(2):126-34.
2004: Shaun M McLoughlin; Neil L Kelleher
Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin.
Journal of the American Chemical Society 2004;126(41):13265-75.
2004: try ty; Fanyu Meng; Steven M Patrie; Leah M. Miller; Neil L Kelleher
Improved molecular weight-based processing of intact proteins for interrogation by quadrupole-enhanced FT MS/MS.
Journal of proteome research 2004;3(4):801-6.
2004: Steven M Patrie; Jay P Charlebois; David Whipple; Neil L Kelleher; Christopher L Hendrickson; John P Quinn; Alan G Marshall; Biswarup Mukhopadhyay
Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa.
Journal of the American Society for Mass Spectrometry 2004;15(7):1099-108.
2004: Richard D LeDuc; Gregory K Taylor; Yong-Bin Kim; Thomas E Januszyk; Lee H Bynum; Joseph V Sola; John S Garavelli; Neil L Kelleher
ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry.
Nucleic acids research 2004;32(Web Server issue):W340-5.
2004: Neil L Kelleher
Top-down proteomics.
Analytical chemistry 2004;76(11):197A-203A.
2004: Fanyu Meng; try ty; Leah M. Miller; Steven M Patrie; Dana E Robinson; Neil L Kelleher
Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics.
Analytical chemistry 2004;76(10):2852-8.
2004: James J Pesavento; Yong-Bin Kim; Gregory K Taylor; Neil L Kelleher
Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry.
Journal of the American Chemical Society 2004;126(11):3386-7.
2004: Andrew J Forbes; Steven M Patrie; Gregory K Taylor; Yong-Bin Kim; Lihua Jiang; Neil L Kelleher
Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2678-83.
2004: Leslie M Hicks; Sarah E O'Connor; Matthew T Mazur; Christopher T Walsh; Neil L Kelleher
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis.
Chemistry & biology 2004;11(3):327-35.
2004: Claire C Tseng; Shaun M McLoughlin; Neil L Kelleher; Christopher T Walsh
Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase.
Biochemistry 2004;43(4):970-80.
2004: Lili Xie; Leah M. Miller; Champak Chatterjee; Olga Averin; Neil L Kelleher; Wilfred Adrianus van der Donk
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity.
Science (New York, N.Y.) 2004;303(5658):679-81.
2003: Matthew T Mazur; Christopher T Walsh; Neil L Kelleher
Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase.
Biochemistry 2003;42(46):13393-400.
2003: Shu He; David Bauman; jamaine davis; Alejandra Loyola; Kenichi Nishioka; Jennifer L Gronlund; Danny Reinberg; Fanyu Meng; Neil L Kelleher; Dewey G McCafferty
Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12033-8.
2003: Gregory K Taylor; Yong-Bin Kim; Andrew J Forbes; Fanyu Meng; Ryan McCarthy; Neil L Kelleher
Web and database software for identification of intact proteins using "top down" mass spectrometry.
Analytical chemistry 2003;75(16):4081-6.
2003: Jay P Charlebois; Steven M Patrie; Neil L Kelleher
Electron capture dissociation and 13C,15N depletion for deuterium localization in intact proteins after solution-phase exchange.
Analytical chemistry 2003;75(13):3263-6.
2002: Jeffrey R Johnson; Fanyu Meng; Andrew J Forbes; Benjamin J Cargile; Neil L Kelleher
Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures.
Electrophoresis 2002;23(18):3217-23.
2002: Fanyu Meng; Benjamin J Cargile; Steven M Patrie; Jeffrey R Johnson; Shaun M McLoughlin; Neil L Kelleher
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry.
Analytical chemistry 2002;74(13):2923-9.
2002: Gary A Valaskovic; Neil L Kelleher
Miniaturized formats for efficient mass spectrometry-based proteomics and therapeutic development.
Current topics in medicinal chemistry 2002;2(1):1-12.
2001: Fanyu Meng; Benjamin J Cargile; Leah M. Miller; Andrew J Forbes; Jeffrey R Johnson; Neil L Kelleher
Informatics and multiplexing of intact protein identification in bacteria and the archaea.
Nature biotechnology 2001;19(10):952-7.
2001: Andrew J Forbes; Matthew T Mazur; Hiten M Patel; Christopher T Walsh; Neil L Kelleher
Toward efficient analysis of >70 kDa proteins with 100% sequence coverage.
Proteomics 2001;1(8):927-33.
2000: RA Zubarev; David M Horn; EK Fridriksson; Neil L Kelleher; N A Kruger; M A Lewis; Barry K Carpenter; Fred W McLafferty
Electron capture dissociation for structural characterization of multiply charged protein cations.
Analytical chemistry 2000;72(3):563-73.
2000: Neil L Kelleher
From primary structure to function: biological insights from large-molecule mass spectra.
Chemistry & biology 2000;7(2):R37-45.
1999: Neil L Kelleher; C L Hendrickson; Christopher T Walsh
Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality.
Biochemistry 1999;38(47):15623-30.
1999: Neil L Kelleher; R A Zubarev; K Bush; Bruce Furie; B C Furie; Fred W McLafferty; Christopher T Walsh
Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid.
Analytical chemistry 1999;71(19):4250-3.
1999: C A Shaw-Reid; Neil L Kelleher; Heather C Losey; AM Gehring; C Berg; Christopher T Walsh
Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization.
Chemistry & biology 1999;6(6):385-400.
1999: R Sinha Roy; Neil L Kelleher; JC Milne; Christopher T Walsh
In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites.
Chemistry & biology 1999;6(5):305-18.
1999: JC Milne; RS Roy; Andrew C Eliot; Neil L Kelleher; A Wokhlu; Bryce E Nickels; Christopher T Walsh
Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17.
Biochemistry 1999;38(15):4768-81.
1998: Fred W McLafferty; Neil L Kelleher; Tadhg P Begley; EK Fridriksson; RA Zubarev; David M Horn
Two-dimensional mass spectrometry of biomolecules at the subfemtomole level.
Current opinion in chemical biology 1998;2(5):571-8.
1998: JC Milne; Andrew C Eliot; Neil L Kelleher; Christopher T Walsh
ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17.
Biochemistry 1998;37(38):13250-61.
1998: Cynthia Kinsland; Sean V Taylor; Neil L Kelleher; Fred W McLafferty; Tadhg P Begley
Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis.
Protein science : a publication of the Protein Society 1998;7(8):1839-42.
1998: Neil L Kelleher; Sean V Taylor; D Grannis; Cynthia Kinsland; HJ Chiu; Tadhg P Begley; Fred W McLafferty
Efficient sequence analysis of the six gene products (7-74 kDa) from the Escherichia coli thiamin biosynthetic operon by tandem high-resolution mass spectrometry.
Protein science : a publication of the Protein Society 1998;7(8):1796-801.
1998: PJ Belshaw; RS Roy; Neil L Kelleher; Christopher T Walsh
Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase.
Chemistry & biology 1998;5(7):373-84.
1998: Sean V Taylor; Neil L Kelleher; Cynthia Kinsland; HJ Chiu; CA Costello; A D Backstrom; Fred W McLafferty; Tadhg P Begley
Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation.
The Journal of biological chemistry 1998;273(26):16555-60.
1997: Neil L Kelleher; Robert B Nicewonger; Tadhg P Begley; F W McLafferty
Identification of modification sites in large biomolecules by stable isotope labeling and tandem high resolution mass spectrometry. The active site nucleophile of thiaminase I.
The Journal of biological chemistry 1997;272(51):32215-20.
1996: G A Valaskovic; Neil L Kelleher; Fred W McLafferty
Attomole protein characterization by capillary electrophoresis-mass spectrometry.
Science (New York, N.Y.) 1996;273(5279):1199-202.
1996: E Mørtz; P B O'Connor; Peter Roepstorff; Neil L Kelleher; Troy D Wood; Fred W McLafferty; Matthias Mann
Sequence tag identification of intact proteins by matching tanden mass spectral data against sequence data bases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8264-7.
1996: C A Costello; Neil L Kelleher; M Abe; Fred W McLafferty; Tadhg P Begley
Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile.
The Journal of biological chemistry 1996;271(7):3445-52.
1995: Troy D Wood; L H Chen; Neil L Kelleher; D P Little; G L Kenyon; Fred W McLafferty
Direct sequence data from heterogeneous creatine kinase (43 kDa) by high-resolution tandem mass spectrometry.
Biochemistry 1995;34(50):16251-4.
1995: G A Valaskovic; Neil L Kelleher; D P Little; D J Aaserud; Fred W McLafferty
Attomole-sensitivity electrospray source for large-molecule mass spectrometry.
Analytical chemistry 1995;67(20):3802-5.