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Neil Kelleher
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29
Walsh, Christopher
15
Dorrestein, Pieter
12
Mizzen, Craig
10
Miller, Leah M.
9
Boyne II, Michael
9
Pesavento, James
9
Forbes, Andrew
8
McLoughlin, Shaun
8
Thomas, Paul
8
van der Donk, Wilfred
7
Meng, Fanyu
7
Patrie, Steven
6
Metcalf, William
6
Kim, Yong-Bin
6
Mazur, Matthew
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All Publications
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2009: Li Mingxi; Jiang Lihua; Kelleher Neil L
Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(30):3885-92.
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2009: Bumpus Stefanie B; Evans Bradley S; Thomas Paul M; Ntai Ioanna; Kelleher Neil L
A proteomics approach to discovering natural products and their biosynthetic pathways.
Nature biotechnology 2009;27(10):951-6.
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2009: Lee M Violet; Ihnken Leigh Anne Furgerson; You Young Ok; McClerren Amanda L; van der Donk Wilfred A; Kelleher Neil L
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry.
Journal of the American Chemical Society 2009;131(34):12258-64.
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2009: Ferguson Jonathan T; Wenger Craig D; Metcalf William W; Kelleher Neil L
Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans.
Journal of the American Society for Mass Spectrometry 2009;20(9):1743-50.
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2009: Evans Bradley S; Kelleher Neil L
To cyclize or not to cyclize: catching enzyme evolution in the act.
ACS chemical biology 2009;4(7):495-7.
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2009: Lee Jin-Hee; Evans Bradley S; Li Gongyong; Kelleher Neil L; van der Donk Wilfred A
In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis.
Biochemistry 2009;48(23):5054-6.
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2009: Yang Xiao-Dong; Huang Bo; Li Mingxi; Lamb Acacia; Kelleher Neil L; Chen Lin-Feng
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.
The EMBO journal 2009;28(8):1055-66.
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2009: Kalaitzis John A; Cheng Qian; Thomas Paul M; Kelleher Neil L; Moore Bradley S
In Vitro Biosynthesis of Unnatural Enterocin and Wailupemycin Polyketides ( perpendicular).
Journal of natural products 2009;72(3):469-72.
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2009: Boyne Michael T; Garcia Benjamin A; Li Mingxi; Zamdborg Leonid; Wenger Craig D; Babai Shannee; Kelleher Neil L
Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval.
Journal of proteome research 2009;8(1):374-9.
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2008: Wenger Craig D; Boyne Michael T; Ferguson Jonathan T; Robinson Dana E; Kelleher Neil L
Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra.
Analytical chemistry 2008;80(21):8055-63.
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2008: Bora Adriana; Annangudi Suresh P; Millet Larry J; Rubakhin Stanislav S; Forbes Andrew J; Kelleher Neil L; Gillette Martha U; Sweedler Jonathan V
Neuropeptidomics of the supraoptic rat nucleus.
Journal of proteome research 2008;7(11):4992-5003.
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2008: Bumpus Stefanie B; Kelleher Neil L
Accessing natural product biosynthetic processes by mass spectrometry.
Current opinion in chemical biology 2008;12(5):475-82.
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2008: Garcia Benjamin A; Thomas C Eric; Kelleher Neil L; Mizzen Craig A
Tissue-specific expression and post-translational modification of histone H3 variants.
Journal of proteome research 2008;7(10):4225-36.
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2008: Calderone Christopher T; Bumpus Stefanie B; Kelleher Neil L; Walsh Christopher T; Magarvey Nathan A
A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12809-14.
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2008: Magarvey Nathan A; Fortin Pascal D; Thomas Paul M; Kelleher Neil L; Walsh Christopher T
Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.
ACS chemical biology 2008;3(9):542-54.
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2008: Eliot Andrew C; Griffin Benjamin M; Thomas Paul M; Johannes Tyler W; Kelleher Neil L; Zhao Huimin; Metcalf William W
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.
Chemistry & biology 2008;15(8):765-70.
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2008: Hatcher Nathan G; Atkins Norman; Annangudi Suresh P; Forbes Andrew J; Kelleher Neil L; Gillette Martha U; Sweedler Jonathan V
Mass spectrometry-based discovery of circadian peptides.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12527-32.
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2008: Pesavento James J; Bullock Courtney R; LeDuc Richard D; Mizzen Craig A; Kelleher Neil L
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.
The Journal of biological chemistry 2008;283(22):14927-37.
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2008: Yang Hongbo; Pesavento James J; Starnes Taylor W; Cryderman Diane E; Wallrath Lori L; Kelleher Neil L; Mizzen Craig A
Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
The Journal of biological chemistry 2008;283(18):12085-92.
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2008: Roth Michael J; Parks Bryan A; Ferguson Jonathan T; Boyne Michael T; Kelleher Neil L
"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry.
Analytical chemistry 2008;80(8):2857-66.
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2008: Zhang Jian; Van Lanen Steven G; Ju Jianhua; Liu Wen; Dorrestein Pieter C; Li Wenli; Kelleher Neil L; Shen Ben
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1460-5.
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2008: Pesavento James J; Yang Hongbo; Kelleher Neil L; Mizzen Craig A
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle.
Molecular and cellular biology 2008;28(1):468-86.
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2007: Parks Bryan A; Jiang Lihua; Thomas Paul M; Wenger Craig D; Roth Michael J; Boyne Michael T; Burke Patricia V; Kwast Kurt E; Kelleher Neil L
Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers.
Analytical chemistry 2007;79(21):7984-91.
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2007: Siuti Nertila; Kelleher Neil L
Decoding protein modifications using top-down mass spectrometry.
Nature methods 2007;4(10):817-21.
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2007: Leduc Richard D; Kelleher Neil L
Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data.
Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.] 2007;Chapter 13():Unit 13.6.
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2007: Jiang Lihua; Smith Jonell N; Anderson Shannon L; Ma Ping; Mizzen Craig A; Kelleher Neil L
Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail.
The Journal of biological chemistry 2007;282(38):27923-34.
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2007: Pesavento James J; Garcia Benjamin A; Streeky James A; Kelleher Neil L; Mizzen Craig A
Mild performic acid oxidation enhances chromatographic and top down mass spectrometric analyses of histones.
Molecular & cellular proteomics : MCP 2007;6(9):1510-26.
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2007: Blodgett Joshua A V; Thomas Paul M; Li Gongyong; Velasquez Juan E; van der Donk Wilfred A; Kelleher Neil L; Metcalf William W
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
Nature chemical biology 2007;3(8):480-5.
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2007: Calderone Christopher T; Iwig David F; Dorrestein Pieter C; Kelleher Neil L; Walsh Christopher T
Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.
Chemistry & biology 2007;14(7):835-46.
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2007: Zamdborg Leonid; LeDuc Richard D; Glowacz Kevin J; Kim Yong-Bin; Viswanathan Vinayak; Spaulding Ian T; Early Bryan P; Bluhm Eric J; Babai Shannee; Kelleher Neil L
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry.
Nucleic acids research 2007;35(Web Server issue):W701-6.
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2007: Garcia Benjamin A; Pesavento James J; Mizzen Craig A; Kelleher Neil L
Pervasive combinatorial modification of histone H3 in human cells.
Nature methods 2007;4(6):487-9.
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2007: Hansen Darren B; Bumpus Stefanie B; Aron Zachary D; Kelleher Neil L; Walsh Christopher T
The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity.
Journal of the American Chemical Society 2007;129(20):6366-7.
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2007: Yin Jun; Straight Paul D; Hrvatin Sinisa; Dorrestein Pieter C; Bumpus Stefanie B; Jao Cindy; Kelleher Neil L; Kolter Roberto; Walsh Christopher T
Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display.
Chemistry & biology 2007;14(3):303-12.
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2007: Kelly Wendy L; Boyne Michael T; Yeh Ellen; Vosburg David A; Galonic Danica P; Kelleher Neil L; Walsh Christopher T
Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.
Biochemistry 2007;46(2):359-68.
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2007: Whitteck John T; Ni Weijuan; Griffin Benjamin M; Eliot Andrew C; Thomas Paul M; Kelleher Neil L; Metcalf William W; van der Donk Wilfred A
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid.
Angewandte Chemie (International ed. in English) 2007;46(47):9089-92.
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2006: Hemp James; Robinson Dana E; Ganesan Krithika B; Martinez Todd J; Kelleher Neil L; Gennis Robert B
Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases.
Biochemistry 2006;45(51):15405-10.
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2006: Dorrestein Pieter C; Kelleher Neil L
Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry.
Natural product reports 2006;23(6):893-918.
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2006: Woodyer Ryan D; Shao Zengyi; Thomas Paul M; Kelleher Neil L; Blodgett Joshua A V; Metcalf William W; van der Donk Wilfred A; Zhao Huimin
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.
Chemistry & biology 2006;13(11):1171-82.
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2006: McClerren Amanda L; Cooper Lisa E; Quan Chao; Thomas Paul M; Kelleher Neil L; van der Donk Wilfred A
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17243-8.
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2006: Dorrestein Pieter C; Bumpus Stefanie B; Calderone Christopher T; Garneau-Tsodikova Sylvie; Aron Zachary D; Straight Paul D; Kolter Roberto; Walsh Christopher T; Kelleher Neil L
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.
Biochemistry 2006;45(42):12756-66.
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2006: Garneau-Tsodikova Sylvie; Dorrestein Pieter C; Kelleher Neil L; Walsh Christopher T
Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.
Journal of the American Chemical Society 2006;128(39):12600-1.
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2006: Van Lanen Steven G; Lin Shuangjun; Dorrestein Pieter C; Kelleher Neil L; Shen Ben
Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
The Journal of biological chemistry 2006;281(40):29633-40.
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2006: Hicks Leslie M; Balibar Carl J; Walsh Christopher T; Kelleher Neil L; Hillson Nathan J
Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry.
Biophysical journal 2006;91(7):2609-19.
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2006: Chan Yolande A; Boyne Michael T; Podevels Angela M; Klimowicz Amy K; Handelsman Jo; Kelleher Neil L; Thomas Michael G
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14349-54.
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2006: Garcia Benjamin A; Joshi Swati; Thomas C Eric; Chitta Raghu K; Diaz Robert L; Busby Scott A; Andrews Philip C; Ogorzalek Loo Rachel R; Shabanowitz Jeffrey; Kelleher Neil L; Mizzen Craig A; Allis C David; Hunt Donald F
Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila.
Molecular & cellular proteomics : MCP 2006;5(9):1593-609.
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2006: Romanova Elena V; Roth Michael J; Rubakhin Stanislav S; Jakubowski Jennifer A; Kelley Wayne P; Kirk Mark D; Kelleher Neil L; Sweedler Jonathan V
Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica.
Journal of mass spectrometry : JMS 2006;41(8):1030-40.
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2006: Dorrestein Pieter C; Van Lanen Steven G; Li Wenli; Zhao Chunhua; Deng Zixin; Shen Ben; Kelleher Neil L
The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis.
Journal of the American Chemical Society 2006;128(32):10386-7.
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2006: Pesavento James J; Mizzen Craig A; Kelleher Neil L
Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.
Analytical chemistry 2006;78(13):4271-80.
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2006: Calderone Christopher T; Kowtoniuk Walter E; Kelleher Neil L; Walsh Christopher T; Dorrestein Pieter C
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):8977-82.
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2006: Hicks Leslie M; Mazur Matthew T; Miller Leah M; Dorrestein Pieter C; Schnarr Nathan A; Khosla Chaitan; Kelleher Neil L
Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry.
Chembiochem : a European journal of chemical biology 2006;7(6):904-7.
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2006: Hicks Leslie M; Moffitt Michelle C; Beer Laura L; Moore Bradley S; Kelleher Neil L
Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase.
ACS chemical biology 2006;1(2):93-102.
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2006: Gatto Gregory J; Boyne Michael T; Kelleher Neil L; Walsh Christopher T
Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster.
Journal of the American Chemical Society 2006;128(11):3838-47.
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2006: Dorrestein Pieter C; Blackhall Jonathan; Straight Paul D; Fischbach Michael A; Garneau-Tsodikova Sylvie; Edwards Daniel J; McLaughlin Shaun; Lin Myat; Gerwick William H; Kolter Roberto; Walsh Christopher T; Kelleher Neil L
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry.
Biochemistry 2006;45(6):1537-46.
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2006: Boyne Michael T; Pesavento James J; Mizzen Craig A; Kelleher Neil L
Precise characterization of human histones in the H2A gene family by top down mass spectrometry.
Journal of proteome research 2006;5(2):248-53.
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2006: Thomas C Eric; Kelleher Neil L; Mizzen Craig A
Mass spectrometric characterization of human histone H3: a bird's eye view.
Journal of proteome research 2006;5(2):240-7.
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2006: Siuti Nertila; Roth Michael J; Mizzen Craig A; Kelleher Neil L; Pesavento James J
Gene-specific characterization of human histone H2B by electron capture dissociation.
Journal of proteome research 2006;5(2):233-9.
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2006: Miller Leah M; Chatterjee Champak; van der Donk Wilfred A; Kelleher Neil L
The dehydratase activity of lacticin 481 synthetase is highly processive.
Journal of the American Chemical Society 2006;128(5):1420-1.
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2006: Du Yi; Parks Bryan A; Sohn Seyoung; Kwast Kurt E; Kelleher Neil L
Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry.
Analytical chemistry 2006;78(3):686-94.
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2006: Patrie Steve M; Ferguson Jonathan T; Robinson Dana E; Whipple Dave; Rother Michael; Metcalf William W; Kelleher Neil L
Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation.
Molecular & cellular proteomics : MCP 2006;5(1):14-25.
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2005: Chatterjee Champak; Miller Leah M; Leung Yong L; Xie Lili; Yi Myongsin; Kelleher Neil L; van der Donk Wilfred A
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production.
Journal of the American Chemical Society 2005;127(44):15332-3.
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2005: Aron Zachary D; Dorrestein Pieter C; Blackhall Jonathan R; Kelleher Neil L; Walsh Christopher T
Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster.
Journal of the American Chemical Society 2005;127(43):14986-7.
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2005: McLoughlin Shaun M; Kelleher Neil L
Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly.
Journal of the American Chemical Society 2005;127(43):14984-5.
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2005: McLoughlin Shaun M; Mazur Matthew T; Miller Leah M; Yin Jun; Liu Fei; Walsh Christopher T; Kelleher Neil L
Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry.
Biochemistry 2005;44(43):14159-69.
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2005: Yin Jun; Straight Paul D; McLoughlin Shaun M; Zhou Zhe; Lin Alison J; Golan David E; Kelleher Neil L; Kolter Roberto; Walsh Christopher T
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15815-20.
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2005: Miller Leah M; Mazur Matthew T; McLoughlin Shaun M; Kelleher Neil L
Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry.
Protein science : a publication of the Protein Society 2005;14(10):2702-12.
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2005: Kelleher Neil L; Hicks Leslie M
Contemporary mass spectrometry for the direct detection of enzyme intermediates.
Current opinion in chemical biology 2005;9(5):424-30.
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2005: Dorrestein Pieter C; Yeh Ellen; Garneau-Tsodikova Sylvie; Kelleher Neil L; Walsh Christopher T
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13843-8.
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2005: Van Lanen Steven G; Dorrestein Pieter C; Christenson Steve D; Liu Wen; Ju Jianhua; Kelleher Neil L; Shen Ben
Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates.
Journal of the American Chemical Society 2005;127(33):11594-5.
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2005: Roth Michael J; Forbes Andrew J; Boyne Michael T; Kim Yong-Bin; Robinson Dana E; Kelleher Neil L
Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry.
Molecular & cellular proteomics : MCP 2005;4(7):1002-8.
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2005: Gatto Gregory J; McLoughlin Shaun M; Kelleher Neil L; Walsh Christopher T
Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.
Biochemistry 2005;44(16):5993-6002.
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2005: Garneau Sylvie; Dorrestein Pieter C; Kelleher Neil L; Walsh Christopher T
Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis.
Biochemistry 2005;44(8):2770-80.
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2005: Meng Fanyu; Forbes Andrew J; Miller Leah M; Kelleher Neil L
Detection and localization of protein modifications by high resolution tandem mass spectrometry.
Mass spectrometry reviews 2005;24(2):126-34.
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2004: McLoughlin Shaun M; Kelleher Neil L
Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin.
Journal of the American Chemical Society 2004;126(41):13265-75.
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2004: Du Yi; Meng Fanyu; Patrie Steven M; Miller Leah M; Kelleher Neil L
Improved molecular weight-based processing of intact proteins for interrogation by quadrupole-enhanced FT MS/MS.
Journal of proteome research 2004;3(4):801-6.
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2004: Patrie Steven M; Charlebois Jay P; Whipple David; Kelleher Neil L; Hendrickson Christopher L; Quinn John P; Marshall Alan G; Mukhopadhyay Biswarup
Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa.
Journal of the American Society for Mass Spectrometry 2004;15(7):1099-108.
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2004: LeDuc Richard D; Taylor Gregory K; Kim Yong-Bin; Januszyk Thomas E; Bynum Lee H; Sola Joseph V; Garavelli John S; Kelleher Neil L
ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry.
Nucleic acids research 2004;32(Web Server issue):W340-5.
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2004: Meng Fanyu; Du Yi; Miller Leah M; Patrie Steven M; Robinson Dana E; Kelleher Neil L
Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics.
Analytical chemistry 2004;76(10):2852-8.
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2004: Hicks Leslie M; O'Connor Sarah E; Mazur Matthew T; Walsh Christopher T; Kelleher Neil L
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis.
Chemistry & biology 2004;11(3):327-35.
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2004: Pesavento James J; Kim Yong-Bin; Taylor Gregory K; Kelleher Neil L
Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry.
Journal of the American Chemical Society 2004;126(11):3386-7.
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2004: Forbes Andrew J; Patrie Steven M; Taylor Gregory K; Kim Yong-Bin; Jiang Lihua; Kelleher Neil L
Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2678-83.
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2004: Tseng Claire C; McLoughlin Shaun M; Kelleher Neil L; Walsh Christopher T
Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase.
Biochemistry 2004;43(4):970-80.
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2004: Xie Lili; Miller Leah M; Chatterjee Champak; Averin Olga; Kelleher Neil L; van der Donk Wilfred A
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity.
Science (New York, N.Y.) 2004;303(5658):679-81.
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2003: Mazur Matthew T; Walsh Christopher T; Kelleher Neil L
Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase.
Biochemistry 2003;42(46):13393-400.
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2003: Taylor Gregory K; Kim Yong-Bin; Forbes Andrew J; Meng Fanyu; McCarthy Ryan; Kelleher Neil L
Web and database software for identification of intact proteins using "top down" mass spectrometry.
Analytical chemistry 2003;75(16):4081-6.
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2003: Charlebois Jay P; Patrie Steven M; Kelleher Neil L
Electron capture dissociation and 13C,15N depletion for deuterium localization in intact proteins after solution-phase exchange.
Analytical chemistry 2003;75(13):3263-6.
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2002: Johnson Jeffrey R; Meng Fanyu; Forbes Andrew J; Cargile Benjamin J; Kelleher Neil L
Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures.
Electrophoresis 2002;23(18):3217-23.
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2002: Meng Fanyu; Cargile Benjamin J; Patrie Steven M; Johnson Jeffrey R; McLoughlin Shaun M; Kelleher Neil L
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry.
Analytical chemistry 2002;74(13):2923-9.
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2001: Meng F; Cargile B J; Miller L M; Forbes A J; Johnson J R; Kelleher N L
Informatics and multiplexing of intact protein identification in bacteria and the archaea.
Nature biotechnology 2001;19(10):952-7.
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2001: Forbes A J; Mazur M T; Patel H M; Walsh C T; Kelleher N L
Toward efficient analysis of >70 kDa proteins with 100% sequence coverage.
Proteomics 2001;1(8):927-33.
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2000: Kelleher N L
From primary structure to function: biological insights from large-molecule mass spectra.
Chemistry & biology 2000;7(2):R37-45.
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1999: Kelleher N L; Hendrickson C L; Walsh C T
Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality.
Biochemistry 1999;38(47):15623-30.
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1999: Kelleher N L; Zubarev R A; Bush K; Furie B; Furie B C; McLafferty F W; Walsh C T
Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid.
Analytical chemistry 1999;71(19):4250-3.
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1999: Shaw-Reid C A; Kelleher N L; Losey H C; Gehring A M; Berg C; Walsh C T
Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization.
Chemistry & biology 1999;6(6):385-400.
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1999: Sinha Roy R; Kelleher N L; Milne J C; Walsh C T
In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites.
Chemistry & biology 1999;6(5):305-18.
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1999: Milne J C; Roy R S; Eliot A C; Kelleher N L; Wokhlu A; Nickels B; Walsh C T
Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17.
Biochemistry 1999;38(15):4768-81.
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1998: Milne J C; Eliot A C; Kelleher N L; Walsh C T
ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17.
Biochemistry 1998;37(38):13250-61.
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1998: Belshaw P J; Roy R S; Kelleher N L; Walsh C T
Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase.
Chemistry & biology 1998;5(7):373-84.
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1996: Mørtz E; O'Connor P B; Roepstorff P; Kelleher N L; Wood T D; McLafferty F W; Mann M
Sequence tag identification of intact proteins by matching tanden mass spectral data against sequence data bases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8264-7.
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1996: Valaskovic G A; Kelleher N L; McLafferty F W
Attomole protein characterization by capillary electrophoresis-mass spectrometry.
Science (New York, N.Y.) 1996;273(5279):1199-202.
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1996: Costello C A; Kelleher N L; Abe M; McLafferty F W; Begley T P
Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile.
The Journal of biological chemistry 1996;271(7):3445-52.
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1995: Wood T D; Chen L H; Kelleher N L; Little D P; Kenyon G L; McLafferty F W
Direct sequence data from heterogeneous creatine kinase (43 kDa) by high-resolution tandem mass spectrometry.
Biochemistry 1995;34(50):16251-4.
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1995: Valaskovic G A; Kelleher N L; Little D P; Aaserud D J; McLafferty F W
Attomole-sensitivity electrospray source for large-molecule mass spectrometry.
Analytical chemistry 1995;67(20):3802-5.
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