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Thomas Keller

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Young Mee Kim; Le Tian Lee; Rong Li; Huichang Annie Lim; Christian G Noble; Pei-Yong Shi; Qing-Yin Wang; John Liang Kuan Wee; Andy Yip; Melgious Jin Yan Ang; Angela Shuyi Chen; Cheng San Brian Chia; Shovanlal Gayen; Jeffrey Hill; Qiwei Huang; Alvin W Hung; Joma Joy; Congbao Kang; Thomas H Keller
NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex.
Neil Press; Helene Sahri; Roger J Taylor; Pamela Tranter; Andrew R Tuffnell; Morris F Tweed; John W Tyler; Trixie Wagner; Nicola Arnold; David Beer; Lyndon Brown; Robert Cheung; Julie Christie; Alastair Denholm; John R Fozard; Joseph D Fullerton; Sandra Haberthuer; Julia D I Hatto; Mark Keenan; Thomas H Keller; Clive McCarthy; Mark K Mercer; Helen Oakman; Alexandre Trifilieff
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Bin Zou; Seh Yong Leong; Louis-Sebastian Sonntag; Peiling Yap; Bryan K S Yeung; Thomas H Keller
Mechanistic study of the spiroindolones: a new class of antimalarials.

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All Publications

2013: Young Mee Kim; Le Tian Lee; Rong Li; Huichang Annie Lim; Christian G Noble; Pei-Yong Shi; Qing-Yin Wang; John Liang Kuan Wee; Andy Yip; Melgious Jin Yan Ang; Angela Shuyi Chen; Cheng San Brian Chia; Shovanlal Gayen; Jeffrey Hill; Qiwei Huang; Alvin W Hung; Joma Joy; Congbao Kang; Thomas H Keller
NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex.
The Journal of biological chemistry 2013;288(18):12891-900.
2012: Neil Press; Helene Sahri; Roger J Taylor; Pamela Tranter; Andrew R Tuffnell; Morris F Tweed; John W Tyler; Trixie Wagner; Nicola Arnold; David Beer; Lyndon Brown; Robert Cheung; Julie Christie; Alastair Denholm; John R Fozard; Joseph D Fullerton; Sandra Haberthuer; Julia D I Hatto; Mark Keenan; Thomas H Keller; Clive McCarthy; Mark K Mercer; Helen Oakman; Alexandre Trifilieff
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Journal of medicinal chemistry 2012;55(17):7472-9.
2012: Bin Zou; Seh Yong Leong; Louis-Sebastian Sonntag; Peiling Yap; Bryan K S Yeung; Thomas H Keller
Mechanistic study of the spiroindolones: a new class of antimalarials.
Molecules (Basel, Switzerland) 2012;17(9):10131-41.
2011: Qing-Yin Wang; Xuping Xie; Hao Ying Xu; Fumiaki Yokokawa; David Chang; Hongping Dong; Anne Goh; Thomas H Keller; Ravinder Reddy Kondreddi; Laura Kramer; Suresh B Lakshminarayana; Shahul Nilar; Min Qing; Ranga Rao; Wouter Schul; Pei-Yong Shi
A translation inhibitor that suppresses dengue virus in vitro and in vivo.
Antimicrobial agents and chemotherapy 2011;55(9):4072-80.
2011: Joseph Cherian; Inhee Choi; Veronique Dartois; Thomas Dick; Michael Goodwin; Young Hwan Ha; Jan Jiricek; Thomas H Keller; Suresh B Lakshminarayana; Yong-Sok Lee; Ujjini H Manjunatha; Tathagata Mukherjee; Amit Nayyar; Pornwaratt Niyomrattanakit; Sindhu Ravindran; Ramandeep Singh; Helena I Boshoff; Clifton E Barry
Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).
Journal of medicinal chemistry 2011;54(16):5639-59.
2010: Matthias Rottmann; Case McNamara; Bryan K S Yeung; Marcus C S Lee; Bin Zou; Bruce Russell; Patrick Seitz; David Plouffe; Neekesh V Dharia; Jocelyn Tan; Steven B Cohen; Kathryn R Spencer; Gonzalo E González-Páez; Suresh B Lakshminarayana; Anne Goh; Rossarin Suwanarusk; Timothy Jegla; Esther K Schmitt; Hans-Peter Beck; Reto Brun; François Nosten; Laurent Renia; Veronique Dartois; Thomas H Keller; Fidock David; Elizabeth A Winzeler; Thierry T Diagana
Spiroindolones, a potent compound class for the treatment of malaria.
Science (New York, N.Y.) 2010;329(5996):1175-80.
2010: Yen-Liang Chen; Zheng Yin; Suresh B Lakshminarayana; Min Qing; Wouter Schul; Jeyaraj Duraiswamy; Ravinder Reddi Kondreddi; Anne Goh; Hao Ying Xu; Andy Yip; Boping Liu; Margaret Weaver; Veronique Dartois; Thomas H Keller; Pei-Yong Shi
Inhibition of dengue virus by an ester prodrug of an adenosine analog.
Antimicrobial agents and chemotherapy 2010;54(8):3255-61.
2010: Bryan K S Yeung; Bin Zou; Matthias Rottmann; Suresh B Lakshminarayana; Shi Hua Ang; Seh Yong Leong; Jocelyn Tan; Josephine Wong; Sonja Keller-Maerki; Christoph Fischli; Anne Goh; Esther K Schmitt; Philipp Krastel; Eric Francotte; Kelli Kuhen; David Plouffe; Kerstin Henson; Trixie Wagner; Elizabeth A Winzeler; Frank Petersen; Reto Brun; Veronique Dartois; Thierry T Diagana; Thomas H Keller
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
Journal of medicinal chemistry 2010;53(14):5155-64.
2010: Yen-Liang Chen; Zheng Yin; Jeyaraj Duraiswamy; Wouter Schul; Chin Chin Lim; Boping Liu; Hao Ying Xu; Min Qing; Andy Yip; Gang Wang; Wai-Ling Chan; Hui Pen Tan; Melissa Lo; Sarah Liung; Ravinder Reddy Kondreddi; Ranga Rao; Helen Gu; Handan He; Thomas H Keller; Pei-Yong Shi
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
Antimicrobial agents and chemotherapy 2010;54(7):2932-9.
2010: Pornwaratt Niyomrattanakit; Yen-Liang Chen; Hongping Dong; Zheng Yin; Min Qing; J Frasier Glickman; Kai Lin; Dieter Mueller; Hans Voshol; Joanne Y H Lim; Shahul Nilar; Thomas H Keller; Pei-Yong Shi
Inhibition of dengue virus polymerase by blocking of the RNA tunnel.
Journal of virology 2010;84(11):5678-86.
2009: Qing-Yin Wang; Sejal J Patel; Eric Vangrevelinghe; Hao Ying Xu; Ranga Rao; Deana Jaber; Wouter Schul; Feng Gu; Olivier Heudi; Ngai Ling Ma; Mee Kian Poh; Wai Yee Phong; Thomas H Keller; Edgar Jacoby; Subhash G Vasudevan
A small-molecule dengue virus entry inhibitor.
Antimicrobial agents and chemotherapy 2009;53(5):1823-31.
2008: Arkadius Pichota; Jeyaraj Duraiswamy; Zheng Yin; Thomas H Keller; Jenefer Alam; Sarah Liung; Gladys Lee; Mei Ding; Gang Wang; Wai-Ling Chan; Mark Schreiber; Ida Ma; David Beer; Xinyi Ngew; Kakoli Mukherjee; Mahesh Nanjundappa; Jeanette W P Teo; Pamela Thayalan; Amelia Yap; Thomas Dick; Wuyi Meng; Mei Xu; James Koehn; Shi-Hao Pan; Kirk Clark; Xiaoling Xie; Carolyn Shoen; Michael Cynamon
Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results.
Bioorganic & medicinal chemistry letters 2008;18(24):6568-72.
2008: Alex Matter; Thomas H Keller
Impact of non-profit organizations on drug discovery: opportunities, gaps, solutions.
Drug discovery today 2008;13(7-8):347-52.
2007: Kristina Löhr; John E Knox; Wai Yee Phong; Ngai Ling Ma; Zheng Yin; Aruna Sampath; Sejal J Patel; Wei-Ling Wang; Wai-Ling Chan; K R Ranga Rao; Gang Wang; Subhash G Vasudevan; Thomas H Keller; Siew Pheng Lim
Yellow fever virus NS3 protease: peptide-inhibition studies.
The Journal of general virology 2007;88(Pt 8):2223-7.
2007: Nichola J Arnold; Ruth Arnold; David Beer; Gurdip Bhalay; Stephen P Collingwood; Sarah Craig; Nicholas Devereux; Mark Dodds; Andrew Dunstan; Robin A Fairhurst; David Farr; Joseph D Fullerton; Angela Glen; Sylvie Gomez; Sandra Haberthuer; Julia D I Hatto; Colin Howes; Darryl Jones; Thomas H Keller; Beate Leuenberger; Heinz Moser; Irene Muller; Reto Naef; Paul A Nicklin; David A Sandham; Katharine L Turner; Morris F Tweed; Simon J Watson; Mauro Zurini
Potent and selective xanthine-based inhibitors of phosphodiesterase 5.
Bioorganic & medicinal chemistry letters 2007;17(8):2376-9.
2006: John E Knox; Ngai Ling Ma; Zheng Yin; Sejal J Patel; Wei-Ling Wang; Wai-Ling Chan; K R Ranga Rao; Gang Wang; Xinyi Ngew; Viral Patel; David Beer; Siew Pheng Lim; Subhash G Vasudevan; Thomas H Keller
Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors.
Journal of medicinal chemistry 2006;49(22):6585-90.
2006: Thomas H Keller; Arkadius Pichota; Zheng Yin
A practical view of 'druggability'.
Current opinion in chemical biology 2006;10(4):357-61.
2006: Paul Erbel; Nikolaus Schiering; Allan D'Arcy; Martin Renatus; Markus Kroemer; Siew Pheng Lim; Zheng Yin; Thomas H Keller; Subhash G Vasudevan; Ulrich Hommel
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nature structural & molecular biology 2006;13(4):372-3.
2006: Thomas H Keller; Yen Liang Chen; John E Knox; Siew Pheng Lim; Ngai Ling Ma; Sejal J Patel; Aruna Sampath; Qing Yin Wang; Zheng Yin; Subhash G Vasudevan
Finding new medicines for flaviviral targets.
Novartis Foundation symposium 2006;277():102-14; discussion 114-9, 251-3.
2006: Zheng Yin; Sejal J Patel; Wei-Ling Wang; Wai-Ling Chan; K R Ranga Rao; Gang Wang; Xinyi Ngew; Viral Patel; David Beer; John E Knox; Ngai Ling Ma; Claus Ehrhardt; Siew Pheng Lim; Subhash G Vasudevan; Thomas H Keller
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(1):40-3.
2006: Zheng Yin; Sejal J Patel; Wei-Ling Wang; Gang Wang; Wai-Ling Chan; K R Ranga Rao; Jenefer Alam; Duraiswamy A Jeyaraj; Xinyi Ngew; Viral Patel; David Beer; Siew Pheng Lim; Subhash G Vasudevan; Thomas H Keller
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.
Bioorganic & medicinal chemistry letters 2006;16(1):36-9.
2005: Neil Press; Roger J Taylor; Joseph D Fullerton; Pamela Tranter; Clive McCarthy; Thomas H Keller; Lyndon Brown; Robert Cheung; Julie Christie; Sandra Haberthuer; Julia D I Hatto; Mark Keenan; Mark K Mercer; Nicola E Press; Helene Sahri; Andrew R Tuffnell; Morris F Tweed; John R Fozard
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.
Bioorganic & medicinal chemistry letters 2005;15(12):3081-5.
2005: Alexandre Trifilieff; Thomas H Keller; Neil Press; Trevor Howe; Peter Gedeck; David Beer; Christoph Walker
CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities.
British journal of pharmacology 2005;144(7):1002-10.
2004: David A Sandham; Lucy Barker; David Beattie; David Beer; Louise Bidlake; David Bentley; Keith D Butler; Sarah Craig; David Farr; Claire Ffoulkes-Jones; John R Fozard; Sandra Haberthuer; Colin Howes; Deborah Hynx; Sarah Jeffers; Thomas H Keller; Paul A Kirkham; Janet C Maas; Lazzaro Mazzoni; Andrew Nicholls; Gaynor E Pilgrim; Elisabeth Schaebulin; Gillian Spooner; Rowan Stringer; Pamela Tranter; Katharine L Turner; Morris F Tweed; Christoph Walker; Simon J Watson; Bernard Cuenoud
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.
Bioorganic & medicinal chemistry 2004;12(19):5213-24.
2004: Neil Press; Thomas H Keller; Pamela Tranter; David Beer; Ken Jones; Alexander Faessler; Richard Heng; Christine Lewis; Trevor Howe; Peter Gedeck; Lazzaro Mazzoni; John R Fozard
New highly potent and selective adenosine A(3) receptor antagonists.
Current topics in medicinal chemistry 2004;4(8):863-70.
2001: Thomas H Keller; K Bray-French; F W Demnitz; T Müller; E Pombo-Villar; Christoph Walker
Synthesis and structure-activity relationship of N-arylrolipram derivatives as inhibitors of PDE4 isozymes.
Chemical & pharmaceutical bulletin 2001;49(8):1009-17.
1998: E Bacher; C Boer; K Bray-French; F W Demnitz; Thomas H Keller; Lazzaro Mazzoni; T Müller; Christoph Walker
N-arylrolipram derivatives as potent and selective PDE4 inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(22):3229-34.