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Paul Kelly

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Vincent Rouet; Roman Bogorad; Christine Kayser; Karima Kessal; Catherine Genestie; Armelle Bardier; David R Grattan; Bruce Kelder; John J Kopchick; Paul A Kelly; Vincent Goffin
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors.
Isabelle Broutin; Jean-Baptiste Jomain; Estelle Tallet; Jan van Agthoven; Bertrand Raynal; Sylviane Hoos; Birthe Kragelund; Paul A Kelly; Arnaud Ducruix; Patrick England; Vincent Goffin
Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
Anne Bachelot; Julie Beaufaron; Nathalie Servel; Cécile Kedzia; Philippe Monget; Paul A Kelly; Geula Gibori; Nadine Binart
Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes.

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2010: Vincent Rouet; Roman Bogorad; Christine Kayser; Karima Kessal; Catherine Genestie; Armelle Bardier; David R Grattan; Bruce Kelder; John J Kopchick; Paul A Kelly; Vincent Goffin
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15199-204.
2010: Isabelle Broutin; Jean-Baptiste Jomain; Estelle Tallet; Jan van Agthoven; Bertrand Raynal; Sylviane Hoos; Birthe Kragelund; Paul A Kelly; Arnaud Ducruix; Patrick England; Vincent Goffin
Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
The Journal of biological chemistry 2010;285(11):8422-33.
2009: Anne Bachelot; Julie Beaufaron; Nathalie Servel; Cécile Kedzia; Philippe Monget; Paul A Kelly; Geula Gibori; Nadine Binart
Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E676-84.
2008: Roman Bogorad; Carine Courtillot; Chidi Mestayer; Sophie Bernichtein; Lilya Harutyunyan; Jean-Baptiste Jomain; Anne Bachelot; Frédérique Kuttenn; Paul A Kelly; Vincent Goffin; Philippe Touraine
Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14533-8.
2008: Estelle Tallet; vincent rouet; Jean-Baptiste Jomain; Paul A Kelly; Sophie Bernichtein; Vincent Goffin
Rational design of competitive prolactin/growth hormone receptor antagonists.
Journal of mammary gland biology and neoplasia 2008;13(1):105-17.
2007: Jean-Baptiste Jomain; Estelle Tallet; Isabelle Broutin; Sylviane Hoos; Jan van Agthoven; Arnaud Ducruix; Paul A Kelly; Birthe Kragelund; Patrick England; Vincent Goffin
Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.
The Journal of biological chemistry 2007;282(45):33118-31.
2006: David Piwnica; Isabelle Fernandez; Nadine Binart; Philippe Touraine; Paul A Kelly; Vincent Goffin
A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D.
Molecular endocrinology (Baltimore, Md.) 2006;20(12):3263-78.
2006: Athanassia Sotiropoulos; Mickael Ohanna; Cécile Kedzia; Ramkumar Menon; John J Kopchick; Paul A Kelly; Mario Pende
Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7315-20.
2006: Karin A Slot; Jan Kastelijn; Anne Bachelot; Paul A Kelly; Nadine Binart; Katja J Teerds
Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice.
Reproduction (Cambridge, England) 2006;131(3):525-32.
2005: Carine Courtillot; Geneviève Plu-Bureau; Nadine Binart; Corinne Balleyguier; Brigitte Sigal-Zafrani; Vincent Goffin; Frédérique Kuttenn; Paul A Kelly; Philippe Touraine
Benign breast diseases.
Journal of mammary gland biology and neoplasia 2005;10(4):325-35.
2005: Cécile Kedzia; ludovic lacroix; Nabahet Ameur; Thierry Ragot; Paul A Kelly; Bernard Caillou; Nadine Binart
Medullary thyroid carcinoma arises in the absence of prolactin signaling.
Cancer research 2005;65(18):8497-503.
2005: Paul A Kelly; Zohra Rahmani
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.
Molecular biology of the cell 2005;16(8):3562-73.
2005: Louise Nilsson; Nadine Binart; Mohammad Bohlooly-Y; Margareta Bramnert; Emil Egecioglu; Jon Kindblom; Paul A Kelly; John J Kopchick; Christopher J Ormandy; Charlotte Ling; Hakan Billig
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.
Biochemical and biophysical research communications 2005;331(4):1120-6.
2005: David J Flint; Maureen T Travers; Michael Barber; Nadine Binart; Paul A Kelly
Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland.
American journal of physiology. Endocrinology and metabolism 2005;288(6):E1179-87.
2005: Vincent Goffin; Sophie Bernichtein; Philippe Touraine; Paul A Kelly
Development and potential clinical uses of human prolactin receptor antagonists.
Endocrine reviews 2005;26(3):400-22.
2005: Mickael Ohanna; Andrew K Sobering; Thomas Lapointe; Lazaro LORENZO; Christophe Praud; Emmanuel Petroulakis; Nahum Sonenberg; Paul A Kelly; Athanassia Sotiropoulos; Mario Pende
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.
Nature cell biology 2005;7(3):286-94.
2005: Don Fleenor; Jon Oden; Paul A Kelly; Subburaman Mohan; Samira Alliouachene; Mario Pende; Sabrina Wentz; Jennifer Kerr; Michael Freemark
Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.
Endocrinology 2005;146(1):103-12.
2004: David Piwnica; Philippe Touraine; Ingrid Struman; Sebastien Tabruyn; Gérard Bolbach; Carmen Clapp; Joseph A Martial; Paul A Kelly; Vincent Goffin
Cathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: study of their antiangiogenic properties and physiological relevance.
Molecular endocrinology (Baltimore, Md.) 2004;18(10):2522-42.
2003: Sophie Bernichtein; Jean-Baptiste Jomain; Paul A Kelly; Vincent Goffin
The N-terminus of human prolactin modulates its biological properties.
Molecular and cellular endocrinology 2003;208(1-2):11-21.
2003: Sophie Bernichtein; Christine Kayser; Karin Dillner; Stéphanie Moulin; John J Kopchick; Joseph A Martial; Gunnar Norstedt; Olle Isaksson; Paul A Kelly; Vincent Goffin
Development of pure prolactin receptor antagonists.
The Journal of biological chemistry 2003;278(38):35988-99.
2003: Vincent Goffin; Sophie Bernichtein; Christine Kayser; Paul A Kelly
Development of new prolactin analogs acting as pure prolactin receptor antagonists.
Pituitary 2003;6(2):89-95.
2003: Nadine Binart; Nathalie Melaine; Charles Pineau; Henri Kercret; Anne-Marie Touzalin; Prune Imbert-Bolloré; Paul A Kelly; Bernard Jégou
Male reproductive function is not affected in prolactin receptor-deficient mice.
Endocrinology 2003;144(9):3779-82.
2003: Stéphanie Moulin; Haniaa Bouzinba-Segard; Paul A Kelly; Joëlle Finidori
Subcellular trafficking of growth hormone receptor and Jak2 under ligand exposure.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(7):396-401.
2003: Fiona G Robertson; Jessica Harris; Matthew J Naylor; Samantha Oakes; Jon Kindblom; Karin Dillner; Håkan Wennbo; Jan Törnell; Paul A Kelly; Jeff Green; Christopher J Ormandy
Prostate development and carcinogenesis in prolactin receptor knockout mice.
Endocrinology 2003;144(7):3196-205.
2003: Elise Saunier; Fariel Dif; Paul A Kelly; Marc Edery
Targeted expression of the dominant-negative prolactin receptor in the mammary gland of transgenic mice results in impaired lactation.
Endocrinology 2003;144(6):2669-75.
2003: Haniaa Bouzinba Segard; Stéphanie Moulin; Stéphanie Boumard; Catherine Augier de Crémiers; Paul A Kelly; Joëlle Finidori
Autocrine growth hormone production prevents apoptosis and inhibits differentiation in C2C12 myoblasts.
Cellular signalling 2003;15(6):615-23.
2003: Nadine Binart; Prune Imbert-Bollore; Nathalie Baran; Céline Viglietta; Paul A Kelly
A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1066-74.
2003: Nathalie Baran; Paul A Kelly; Nadine Binart
Decysin, a new member of the metalloproteinase family, is regulated by prolactin and steroids during mouse pregnancy.
Biology of reproduction 2003;68(5):1787-92.
2003: Isabelle Grosdemouge; Anne Bachelot; Aurélie Lucas; Nathalie Baran; Paul A Kelly; Nadine Binart
Effects of deletion of the prolactin receptor on ovarian gene expression.
Reproductive biology and endocrinology : RB&E 2003;1():12.
2003: Sophie Bernichtein; Sébastien Jeay; Roland Vaudry; Paul A Kelly; Vincent Goffin
New homologous bioassays for human lactogens show that agonism or antagonism of various analogs is a function of assay sensitivity.
Endocrine 2003;20(1-2):177-90.
2003: Christopher J Ormandy; Matthew Naylor; Jessica Harris; Fiona G Robertson; Nelson D Horseman; Geoffrey J Lindeman; Jane E Visvader; Paul A Kelly
Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice.
Recent progress in hormone research 2003;58():297-323.
2003: Stéphanie Moulin; Haniaa Bouzinba-Segard; Paul A Kelly; Joëlle Finidori
Jak2 and proteasome activities control the availability of cell surface growth hormone receptors during ligand exposure.
Cellular signalling 2003;15(1):47-55.
2002: Paul A Kelly; Anne Bachelot; Cécile Kedzia; Lothar Hennighausen; Christopher J Ormandy; John J Kopchick; Nadine Binart
The role of prolactin and growth hormone in mammary gland development.
Molecular and cellular endocrinology 2002;197(1-2):127-31.
2002: Gordon J Allan; Elizabeth Tonner; Michael Barber; Maureen T Travers; John H Shand; Richard G Vernon; Paul A Kelly; Nadine Binart; David J Flint
Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.
Endocrinology 2002;143(11):4310-9.
2002: Anne Bachelot; Philippe Monget; Prune Imbert-Bolloré; Karen Coshigano; John J Kopchick; Paul A Kelly; Nadine Binart
Growth hormone is required for ovarian follicular growth.
Endocrinology 2002;143(10):4104-12.
2002: Nathalie Baran; Paul A Kelly; Nadine Binart
Characterization of a prolactin-regulated gene in reproductive tissues using the prolactin receptor knockout mouse model.
Biology of reproduction 2002;66(4):1210-8.
2002: Michael Freemark; Isabelle Avril; Don Fleenor; Phyllis Driscoll; Ann Petro; Emmanuel C Opara; William F Kendall; Jon Oden; Spencer Bridges; Nadine Binart; Bernadette Breant; Paul A Kelly
Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance.
Endocrinology 2002;143(4):1378-85.
2002: Sébastien Jeay; Gail E Sonenshein; Marie Catherine Postel-Vinay; Paul A Kelly; Elena Baixeras
Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways.
Molecular and cellular endocrinology 2002;188(1-2):1-7.
2001: Fariel Dif; E Saunier; Barbara A Demeneix; Paul A Kelly; Marc Edery
Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor.
Endocrinology 2001;142(12):5286-93.
2001: Sophie Bernichtein; Sandrina Kinet; Sébastien Jeay; M Llovera; D Madern; Joseph A Martial; Paul A Kelly; Vincent Goffin
S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist.
Endocrinology 2001;142(9):3950-63.
2001: Elena Baixeras; Sébastien Jeay; Paul A Kelly; Marie Catherine Postel-Vinay
The proliferative and antiapoptotic actions of growth hormone and insulin-like growth factor-1 are mediated through distinct signaling pathways in the Pro-B Ba/F3 cell line.
Endocrinology 2001;142(7):2968-77.
2001: F Ammarguellat; M Llovera; Paul A Kelly; Vincent Goffin
Low doses of EPO activate MAP kinases but not JAK2-STAT5 in rat vascular smooth muscle cells.
Biochemical and biophysical research communications 2001;284(4):1031-8.
2001: Anthony Craven; Christopher J Ormandy; Fiona G Robertson; Richard J Wilkins; Paul A Kelly; Allan J Nixon; Allan J Pearson
Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice.
Endocrinology 2001;142(6):2533-9.
2001: Paul A Kelly; Nadine Binart; Michael Freemark; B Lucas; Vincent Goffin; B Bouchard
Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice.
Biochemical Society transactions 2001;29(Pt 2):48-52.
2001: Paul A Kelly; Nadine Binart; B Lucas; B Bouchard; Vincent Goffin
Implications of multiple phenotypes observed in prolactin receptor knockout mice.
Frontiers in neuroendocrinology 2001;22(2):140-5.
2001: Paul A Kelly; Joëlle Finidori; Stéphanie Moulin; Cécile Kedzia; Nadine Binart
Growth hormone receptor signalling and actions in bone growth.
Hormone research 2001;55 Suppl 2():14-7.
2001: Sébastien Jeay; Gail E Sonenshein; Paul A Kelly; Marie Catherine Postel-Vinay; Elena Baixeras
Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-kappaB and phosphatidylinositol 3-kinase.
Endocrinology 2001;142(1):147-56.
2001: Kathy McClellan; Fiona G Robertson; Jon Kindblom; Håkan Wennbo; Jan Törnell; B Bouchard; Paul A Kelly; Christopher J Ormandy
Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice.
Investigative ophthalmology & visual science 2001;42(1):23-30.
2000: Natalie Sims; Philippe Clément-Lacroix; F Da Ponte; Y Bouali; Nadine Binart; R Moriggl; Vincent Goffin; Karen T Coschigano; Martine Gaillard-Kelly; J Kopchick; Roland Baron; Paul A Kelly
Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.
The Journal of clinical investigation 2000;106(9):1095-103.
2000: M Llovera; C Pichard; Sophie Bernichtein; Sébastien Jeay; Philippe Touraine; Paul A Kelly; Vincent Goffin
Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation.
Oncogene 2000;19(41):4695-705.
2000: H Favre-Young; Fariel Dif; F Roussille; Barbara A Demeneix; Paul A Kelly; Marc Edery; Amaury de Luze
Cross-talk between signal transducer and activator of transcription (Stat5) and thyroid hormone receptor-beta 1 (TRbeta1) signaling pathways.
Molecular endocrinology (Baltimore, Md.) 2000;14(9):1411-24.
2000: H Dinerstein-Cali; F Ferrag; C Kayser; Paul A Kelly; Marie Catherine Postel-Vinay
Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins.
Molecular and cellular endocrinology 2000;166(2):89-99.
2000: Nadine Binart; C Helloco; Christopher J Ormandy; Jacqueline Barra; Philippe Clément-Lacroix; Nathalie Baran; Paul A Kelly
Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration.
Endocrinology 2000;141(7):2691-7.
2000: M Llovera; Philippe Touraine; Paul A Kelly; Vincent Goffin
Involvement of prolactin in breast cancer: redefining the molecular targets.
Experimental gerontology 2000;35(1):41-51.
2000: C Bole-Feysot; E Perret; P Roustan; B Bouchard; Paul A Kelly
Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques.
Genome biology 2000;1(4):RESEARCH0008.
2000: Nadine Binart; Christopher J Ormandy; Paul A Kelly
Mammary gland development and the prolactin receptor.
Advances in experimental medicine and biology 2000;480():85-92.
1999: Vincent Goffin; Nadine Binart; Philippe Clément-Lacroix; B Bouchard; C Bole-Feysot; Marc Edery; B K Lucas; Philippe Touraine; A Pezet; R Maaskant; C Pichard; C Helloco; Nathalie Baran; H Favre; Sophie Bernichtein; A Allamando; Christopher J Ormandy; Paul A Kelly
From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models.
Genetic analysis : biomolecular engineering 1999;15(3-5):189-201.
1999: Sandrina Kinet; Sophie Bernichtein; Paul A Kelly; Joseph A Martial; Vincent Goffin
Biological properties of human prolactin analogs depend not only on global hormone affinity, but also on the relative affinities of both receptor binding sites.
The Journal of biological chemistry 1999;274(37):26033-43.
1999: A Pezet; H Favre; Paul A Kelly; Marc Edery
Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling.
The Journal of biological chemistry 1999;274(35):24497-502.
1999: Vincent Goffin; Sophie Bernichtein; O Carrière; W F Bennett; John J Kopchick; Paul A Kelly
The human growth hormone antagonist B2036 does not interact with the prolactin receptor.
Endocrinology 1999;140(8):3853-6.
1999: B Bouchard; Christopher J Ormandy; James P Di Santo; Paul A Kelly
Immune system development and function in prolactin receptor-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):576-82.
1999: H Favre; A Benhamou; Joëlle Finidori; Paul A Kelly; Marc Edery
Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction.
FEBS letters 1999;453(1-2):63-6.
1999: Vincent Goffin; Philippe Touraine; C Pichard; Sophie Bernichtein; Paul A Kelly
Should prolactin be reconsidered as a therapeutic target in human breast cancer?
Molecular and cellular endocrinology 1999;151(1-2):79-87.
1999: Philippe Clément-Lacroix; Christopher J Ormandy; Liên Lepescheux; Patrick Ammann; Diane Damotte; Vincent Goffin; B Bouchard; Michael Amling; Martine Gaillard-Kelly; Nadine Binart; Roland Baron; Paul A Kelly
Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice.
Endocrinology 1999;140(1):96-105.
1998: B K Lucas; Christopher J Ormandy; Nadine Binart; R S Bridges; Paul A Kelly
Null mutation of the prolactin receptor gene produces a defect in maternal behavior.
Endocrinology 1998;139(10):4102-7.
1998: Christopher J Ormandy; Nadine Binart; C Helloco; Paul A Kelly
Mouse prolactin receptor gene: genomic organization reveals alternative promoter usage and generation of isoforms via alternative 3'-exon splicing.
DNA and cell biology 1998;17(9):761-70.
1998: N Esposito; J Wojcik; Jacques Chomilier; JF Martini; Paul A Kelly; J Finidori; Marie Catherine Postel-Vinay
The D152H mutation found in growth hormone insensitivity syndrome impairs expression and function of human growth hormone receptor but is silent in rat receptor.
Journal of molecular endocrinology 1998;21(1):61-72.
1998: Henry N Jabbour; LA Clarke; T Bramley; Marie Catherine Postel-Vinay; Paul A Kelly; Marc Edery
Alternative splicing of the prolactin receptor gene generates a 1.7 kb RNA transcript that is linked to prolactin function in the red deer testis.
Journal of molecular endocrinology 1998;21(1):51-9.
1998: F Sohm; I Manfroid; A Pezet; F Rentier-Delrue; M Rand-Weaver; Paul A Kelly; G Boeuf; Marie Catherine Postel-Vinay; Amaury de Luze; Marc Edery
Identification and modulation of a growth hormone-binding protein in rainbow trout (Oncorhynchus mykiss) plasma during seawater adaptation.
General and comparative endocrinology 1998;111(2):216-24.
1998: S Moutoussamy; Paul A Kelly; J Finidori
Growth-hormone-receptor and cytokine-receptor-family signaling.
European journal of biochemistry / FEBS 1998;255(1):1-11.
1998: S Moutoussamy; F Renaudie; F Lago; Paul A Kelly; J Finidori
Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
The Journal of biological chemistry 1998;273(26):15906-12.
1998: C Bole-Feysot; Vincent Goffin; Marc Edery; Nadine Binart; Paul A Kelly
Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Endocrine reviews 1998;19(3):225-68.
1998: Vincent Goffin; B Bouchard; Christopher J Ormandy; E Weimann; F Ferrag; Philippe Touraine; C Bole-Feysot; R A Maaskant; P Clement-Lacroix; Marc Edery; Nadine Binart; Paul A Kelly
Prolactin: a hormone at the crossroads of neuroimmunoendocrinology.
Annals of the New York Academy of Sciences 1998;840():498-509.
1998: Henry N Jabbour; LA Clarke; A S McNeilly; Marc Edery; Paul A Kelly
Is prolactin a gonadotrophic hormone in red deer (Cervus elaphus)? Pattern of expression of the prolactin receptor gene in the testis and epididymis.
Journal of molecular endocrinology 1998;20(2):175-82.
1998: H Buteau; A Pezet; F Ferrag; Martine Perrot-Applanat; Paul A Kelly; Marc Edery
N-glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting.
Molecular endocrinology (Baltimore, Md.) 1998;12(4):544-55.
1998: Philippe Touraine; JF Martini; Brigitte Zafrani; Jean-Claude Durand; F Labaille; Catherine Malet; Alain Nicolas; C Trivin; Marie Catherine Postel-Vinay; Frédérique Kuttenn; Paul A Kelly
Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues.
The Journal of clinical endocrinology and metabolism 1998;83(2):667-74.
1998: F Ferrag; A Pezet; A Chiarenza; H Buteau; B H Nelson; Vincent Goffin; Paul A Kelly
Homodimerization of IL-2 receptor beta chain is necessary and sufficient to activate Jak2 and downstream signaling pathways.
FEBS letters 1998;421(1):32-6.
1997: Christopher J Ormandy; R E Hall; DL Manning; John F R Robertson; Roger W Blamey; Paul A Kelly; Robert I Nicholson; Robert L Sutherland
Coexpression and cross-regulation of the prolactin receptor and sex steroid hormone receptors in breast cancer.
The Journal of clinical endocrinology and metabolism 1997;82(11):3692-9.
1997: A Pezet; F Ferrag; Paul A Kelly; Marc Edery
Tyrosine docking sites of the rat prolactin receptor required for association and activation of stat5.
The Journal of biological chemistry 1997;272(40):25043-50.
1997: Christopher J Ormandy; Nadine Binart; Paul A Kelly
Mammary gland development in prolactin receptor knockout mice.
Journal of mammary gland biology and neoplasia 1997;2(4):355-64.
1997: F Ferrag; Vincent Goffin; H Buteau; Paul A Kelly
Immune function of prolactin (PRL) and signal transduction by PRL/GH/cytokine receptors: specificity, redundancy and lessons from chimaeras.
Cytokines, cellular & molecular therapy 1997;3(3):197-213.
1997: J J Berlanga; J P Garcia-Ruiz; Martine Perrot-Applanat; Paul A Kelly; Marc Edery
The short form of the prolactin (PRL) receptor silences PRL induction of the beta-casein gene promoter.
Molecular endocrinology (Baltimore, Md.) 1997;11(10):1449-57.
1997: LM Sachs; J J Lebrun; Amaury de Luze; Paul A Kelly; Barbara A Demeneix
Tail regression, apoptosis and thyroid hormone regulation of myosin heavy chain isoforms in Xenopus tadpoles.
Molecular and cellular endocrinology 1997;131(2):211-9.
1997: JF Martini; A Pezet; C Y Guezennec; Marc Edery; Marie Catherine Postel-Vinay; Paul A Kelly
Monkey growth hormone (GH) receptor gene expression. Evidence for two mechanisms for the generation of the GH binding protein.
The Journal of biological chemistry 1997;272(30):18951-8.
1997: Martine Perrot-Applanat; Oreste Gualillo; A Pezet; V Vincent; Marc Edery; Paul A Kelly
Dominant negative and cooperative effects of mutant forms of prolactin receptor.
Molecular endocrinology (Baltimore, Md.) 1997;11(8):1020-32.
1997: A Pezet; H Buteau; Paul A Kelly; Marc Edery
The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.
Molecular and cellular endocrinology 1997;129(2):199-208.
1997: Martine Perrot-Applanat; Oreste Gualillo; H Buteau; Marc Edery; Paul A Kelly
Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation.
Journal of cell science 1997;110 ( Pt 9)():1123-32.
1997: V Vincent; V Goffin; M Rozakis-Adcock; J P Mornon; Paul A Kelly
Identification of cytoplasmic motifs required for short prolactin receptor internalization.
The Journal of biological chemistry 1997;272(11):7062-8.
1997: Michael Freemark; Phyllis Driscoll; R Maaskant; Anna Petryk; Paul A Kelly
Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.
The Journal of clinical investigation 1997;99(5):1107-17.
1997: Juan J Berlanga; Oreste Gualillo; H Buteau; M Applanat; Paul A Kelly; Marc Edery
Prolactin activates tyrosyl phosphorylation of insulin receptor substrate 1 and phosphatidylinositol-3-OH kinase.
The Journal of biological chemistry 1997;272(4):2050-2.
1997: Christopher J Ormandy; A Camus; Jacqueline Barra; Diane Damotte; B Lucas; H Buteau; Marc Edery; N Brousse; Charles Babinet; Nadine Binart; Paul A Kelly
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.
Genes & development 1997;11(2):167-78.
1997: Vincent Goffin; Paul A Kelly
The prolactin/growth hormone receptor family: structure/function relationships.
Journal of mammary gland biology and neoplasia 1997;2(1):7-17.
1996: Henry N Jabbour; L A Clarke; Sheila C Boddy; A Pezet; Marc Edery; Paul A Kelly
Cloning, sequencing and functional analysis of a truncated cDNA encoding red deer prolactin receptor: an alternative tyrosine residue mediates beta-casein promoter activation.
Molecular and cellular endocrinology 1996;123(1):17-26.
1996: Vincent Goffin; K T Shiverick; Paul A Kelly; Joseph A Martial
Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals.
Endocrine reviews 1996;17(4):385-410.
1996: A Sotiropoulos; S Moutoussamy; F Renaudie; M Clauss; C Kayser; Fabrice Gouilleux; Paul A Kelly; J Finidori
Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor.
Molecular endocrinology (Baltimore, Md.) 1996;10(8):998-1009.
1996: Vincent Goffin; S Kinet; F Ferrag; Nadine Binart; Joseph A Martial; Paul A Kelly
Antagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay.
The Journal of biological chemistry 1996;271(28):16573-9.
1996: L Sachs; Amaury de Luze; J J Lebrun; Paul A Kelly; Barbara A Demeneix
Use of heterologous DNA-based gene transfer to follow physiological, T3-dependent regulation of myosin heavy chain genes in Xenopus tadpoles.
Endocrinology 1996;137(5):2191-4.
1996: F Ferrag; A Chiarenza; Vincent Goffin; Paul A Kelly
Convergence of signaling transduced by prolactin (PRL)/cytokine chimeric receptors on PRL-responsive gene transcription.
Molecular endocrinology (Baltimore, Md.) 1996;10(4):451-60.
1995: H Dinerstein; F Lago; L Goujon; F Ferrag; N Esposito; J Finidori; Paul A Kelly; Marie Catherine Postel-Vinay
The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription.
Molecular endocrinology (Baltimore, Md.) 1995;9(12):1701-7.
1995: Yael Sandowski; M Nagano; C Bignon; Jean Djiane; Paul A Kelly; Arieh Gertler
Preparation and characterization of recombinant prolactin receptor extracellular domain from rat.
Molecular and cellular endocrinology 1995;115(1):1-11.
1995: H A Lochnan; H Buteau; S Richards; Marc Edery; Paul A Kelly
Functional activity of the human prolactin receptor and its ligands.
Molecular and cellular endocrinology 1995;114(1-2):91-9.
1995: A Sotiropoulos; S Moutoussamy; N Binart; Paul A Kelly; J Finidori
The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3.
FEBS letters 1995;369(2-3):169-72.
1995: L A Clarke; Marc Edery; Andrew S I Loudon; Valerie A Randall; M C Postel-Vinay; Paul A Kelly; Henry N Jabbour
Expression of the prolactin receptor gene during the breeding and non-breeding seasons in red deer (Cervus elaphus): evidence for the expression of two forms in the testis.
The Journal of endocrinology 1995;146(2):313-21.
1995: G Allevato; Nils Billestrup; L Goujon; Elisabeth D Galsgaard; Gunnar Norstedt; Marie Catherine Postel-Vinay; Paul A Kelly; Jens H Nielsen
Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation.
The Journal of biological chemistry 1995;270(29):17210-4.
1995: O Sandra; F Sohm; Amaury de Luze; P Prunet; Marc Edery; Paul A Kelly
Expression cloning of a cDNA encoding a fish prolactin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6037-41.
1995: J J Lebrun; S Ali; V Goffin; A Ullrich; Paul A Kelly
A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):4031-5.
1995: J F Martini; S M Villares; M Nagano; M C Delehaye-Zervas; B Eymard; Paul A Kelly; Marie Catherine Postel-Vinay
Quantitative analysis by polymerase chain reaction of growth hormone receptor gene expression in human liver and muscle.
Endocrinology 1995;136(4):1355-60.
1995: M Nagano; Eric Chastre; A Choquet; J Bara; Christian Gespach; Paul A Kelly
Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract.
The American journal of physiology 1995;268(3 Pt 1):G431-42.
1995: Marie Catherine Postel-Vinay; J Finidori; A Sotiropoulos; H Dinerstein; J F Martini; Paul A Kelly
[Growth hormone receptor. Structure and signal transduction].
Annales d'endocrinologie 1995;56(3):209-12.
1994: A Sotiropoulos; M Perrot-Applanat; H Dinerstein; A Pallier; Marie Catherine Postel-Vinay; J Finidori; Paul A Kelly
Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.
Endocrinology 1994;135(4):1292-8.
1994: F Ferrag; J J Lebrun; Philippe Touraine; M Nagano; M Dardenne; Paul A Kelly
Prolactin and the immune system.
ImmunoMethods 1994;5(1):21-30.
1994: N Esposito; P Paterlini; Paul A Kelly; Marie Catherine Postel-Vinay; J Finidori
Expression of two isoforms of the human growth hormone receptor in normal liver and hepatocarcinoma.
Molecular and cellular endocrinology 1994;103(1-2):13-20.
1994: Paul A Kelly; Marc Edery; J Finidori; Marie Catherine Postel-Vinay; L Gougon; S Ali; H Dinerstein; A Sotiropoulos; H Lochnan; F Ferrag
Receptor domains involved in signal transduction of prolactin and growth hormone.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):280-3.
1994: Marc Edery; C Levi-Meyrueis; Jacqueline Paly; Paul A Kelly; Jean Djiane
A limited cytoplasmic region of the prolactin receptor critical for signal transduction.
Molecular and cellular endocrinology 1994;102(1-2):39-44.
1994: J J Lebrun; S Ali; L Sofer; A Ullrich; Paul A Kelly
Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2.
The Journal of biological chemistry 1994;269(19):14021-6.
1994: M Nagano; Paul A Kelly
Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction.
The Journal of biological chemistry 1994;269(18):13337-45.
1994: Paul A Kelly; Marie Catherine Postel-Vinay; J Finidori; Marc Edery; A Sotiropoulos; L Goujon; N Esposito
Growth hormone receptor structure, dimerization and function.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1994;399():107-11.
1994: N Genty; Jacqueline Paly; Marc Edery; Paul A Kelly; Jean Djiane; Roland Salesse
Endocytosis and degradation of prolactin and its receptor in Chinese hamster ovary cells stably transfected with prolactin receptor cDNA.
Molecular and cellular endocrinology 1994;99(2):221-8.
1994: Paul A Kelly; L Goujon; A Sotiropoulos; H Dinerstein; N Esposito; Marc Edery; J Finidori; Marie Catherine Postel-Vinay
The GH receptor and signal transduction.
Hormone research 1994;42(4-5):133-9.
1993: L Lesueur; Marc Edery; Jacqueline Paly; Paul A Kelly; Jean Djiane
Roles of extracellular and cytoplasmic domains of the prolactin receptor in signal transduction to milk protein genes.
Molecular endocrinology (Baltimore, Md.) 1993;7(9):1178-84.
1993: Marie Catherine Postel-Vinay; J Léger; A Sotiropoulos; M C Delehaye-Zervas; J Finidori; Paul A Kelly
Regulation of growth hormone-binding protein: clinical implications.
The Journal of pediatric endocrinology 1993;6(3-4):241-4.
1993: A Sotiropoulos; L Goujon; G Simonin; Paul A Kelly; Marie Catherine Postel-Vinay; J Finidori
Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor.
Endocrinology 1993;132(4):1863-5.
1993: Marc Edery; M Rozakis-Adcock; L Goujon; J Finidori; C Lévi-Meyrueis; Jacqueline Paly; Jean Djiane; Marie Catherine Postel-Vinay; Paul A Kelly
Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.
The Journal of clinical investigation 1993;91(3):838-44.
1993: Paul A Kelly; Suhad Ali; M Rozakis; L Goujon; M Nagano; I Pellegrini; Dinah Gould; Jean Djiane; Marc Edery; J Finidori
The growth hormone/prolactin receptor family.
Recent progress in hormone research 1993;48():123-64.
1992: A Dorato; S Raguet; H Okamura; John J M Bergeron; Paul A Kelly; Barry Posner
Characterization of the structure and glycosylation properties of intracellular and cell surface rat hepatic prolactin receptors.
Endocrinology 1992;131(4):1734-42.
1992: Suhad Ali; Marc Edery; I Pellegrini; L Lesueur; Jacqueline Paly; Jean Djiane; Paul A Kelly
The Nb2 form of prolactin receptor is able to activate a milk protein gene promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(8):1242-8.
1992: I Pellegrini; J J Lebrun; S Ali; Paul A Kelly
Expression of prolactin and its receptor in human lymphoid cells.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1023-31.
1992: M Rozakis-Adcock; Paul A Kelly
Identification of ligand binding determinants of the prolactin receptor.
The Journal of biological chemistry 1992;267(11):7428-33.
1992: M Nagano; Paul A Kelly
Absence of a putative ATP/GTP binding site in the rat prolactin receptor.
Biochemical and biophysical research communications 1992;183(2):610-8.
1991: Suhad Ali; I Pellegrini; Paul A Kelly
A prolactin-dependent immune cell line (Nb2) expresses a mutant form of prolactin receptor.
The Journal of biological chemistry 1991;266(30):20110-7.
1991: M Rozakis-Adcock; Paul A Kelly
Mutational analysis of the ligand-binding domain of the prolactin receptor.
The Journal of biological chemistry 1991;266(25):16472-7.
1991: Paul A Kelly; Jean Djiane; M C Postel-Vinay; Marc Edery
The prolactin/growth hormone receptor family.
Endocrine reviews 1991;12(3):235-51.
1991: Marie Catherine Postel-Vinay; L Belair; C Kayser; Paul A Kelly; Jean Djiane
Identification of prolactin and growth hormone binding proteins in rabbit milk.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6687-90.
1991: G A Jahn; Marc Edery; Lucette Belair; Paul A Kelly; Jean Djiane
Prolactin receptor gene expression in rat mammary gland and liver during pregnancy and lactation.
Endocrinology 1991;128(6):2976-84.
1991: I Dusanter-Fourt; P Gaye; Lucette Belair; B Pétridou; Paul A Kelly; Jean Djiane
Prolactin receptor gene expression in the rabbit: identification, characterization and tissue distribution of several prolactin receptor messenger RNAs encoding a unique precursor.
Molecular and cellular endocrinology 1991;77(1-3):181-92.
1991: L Lesueur; Marc Edery; Suhad Ali; Jacqueline Paly; Paul A Kelly; Jean Djiane
Comparison of long and short forms of the prolactin receptor on prolactin-induced milk protein gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):824-8.
1991: G A Jahn; F Diolez-Bojda; Lucette Belair; Bernard Kerdelhué; Paul A Kelly; Jean Djiane; Marc Edery
Effect of DMBA on the expression of prolactin receptors and IGF1 genes in rat mammary gland.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1991;45(1):15-22.
1991: Marie Catherine Postel-Vinay; J Finidori; L Goujon; J F Martini; M C Delehaye Zervas; Paul A Kelly
[Growth hormone receptor].
Annales d'endocrinologie 1991;52(6):469-73.
1990: M Shirota; Denis Banville; Suhad Ali; C Jolicoeur; J M Boutin; Marc Edery; Jean Djiane; Paul A Kelly
Expression of two forms of prolactin receptor in rat ovary and liver.
Molecular endocrinology (Baltimore, Md.) 1990;4(8):1136-43.
1990: L Lesueur; Marc Edery; Jacqueline Paly; J Clark; Paul A Kelly; Jean Djiane
Prolactin stimulates milk protein promoter in CHO cells cotransfected with prolactin receptor cDNA.
Molecular and cellular endocrinology 1990;71(1):R7-12.
1989: J M Boutin; Marc Edery; M Shirota; C Jolicoeur; L Lesueur; Suhad Ali; D Gould; Jean Djiane; Paul A Kelly
Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1455-61.
1989: C Jolicoeur; J M Boutin; H Okamura; S Raguet; Jean Djiane; Paul A Kelly
Multiple regulation of prolactin receptor gene expression in rat liver.
Molecular endocrinology (Baltimore, Md.) 1989;3(6):895-900.
1989: H Okamura; J Zachwieja; S Raguet; Paul A Kelly
Characterization and applications of monoclonal antibodies to the prolactin receptor.
Endocrinology 1989;124(5):2499-508.
1989: H Okamura; S Raguet; A Bell; J Gagnon; Paul A Kelly
Purification and protein sequence analysis of rat liver prolactin receptor.
The Journal of biological chemistry 1989;264(10):5904-11.
1989: Marc Edery; C Jolicoeur; C Levi-Meyrueis; I Dusanter-Fourt; B Pétridou; J M Boutin; L Lesueur; Paul A Kelly; Jean Djiane
Identification and sequence analysis of a second form of prolactin receptor by molecular cloning of complementary DNA from rabbit mammary gland.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):2112-6.
1989: C Jolicoeur; J M Boutin; H Okamura; J Gagnon; Marc Edery; M Shirota; Denis Banville; I Dusanter-Fourt; Jean Djiane; Paul A Kelly
[Prolactin receptor: characterization by monoclonal antibodies and cloning of complementary DNA].
Pathologie-biologie 1989;37(3):215-21.
1989: L Jeandel; H Okamura; M Belles-Isles; Jean-Guy Chabot; F Dihl; G Morel; Paul A Kelly; S Heisler
Immunocytochemical localization, binding, and effects of atrial natriuretic peptide in rat adipocytes.
Molecular and cellular endocrinology 1989;62(1):69-78.
1989: I Dusanter-Fourt; Paul A Kelly; Jean Djiane
Partial proteolytic digestion of the mammary prolactin receptor: identification of smaller prolactin binding fragments.
Journal of receptor research 1989;9(6):479-93.
1989: Paul A Kelly; J M Boutin; C Jolicoeur; H Okamura; M Shirota; Marc Edery; I Dusanter-Fourt; Jean Djiane
Purification, cloning, and expression of the prolactin receptor.
Biology of reproduction 1989;40(1):27-32.
1988: H Okamura; Paul A Kelly; Jean-Guy Chabot; G Morel; M Belles-Isles; S Heisler
Atrial natriuretic peptide receptors are present in brown adipose tissue.
Biochemical and biophysical research communications 1988;156(2):1000-6.
1988: J M Boutin; C Jolicoeur; H Okamura; J Gagnon; Marc Edery; M Shirota; Denis Banville; I Dusanter-Fourt; Jean Djiane; Paul A Kelly
Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family.
Cell 1988;53(1):69-77.
1987: M Katoh; S Raguet; J Zachwieja; Jean Djiane; Paul A Kelly
Hepatic prolactin receptors in the rat: characterization using monoclonal antireceptor antibodies.
Endocrinology 1987;120(2):739-49.