FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Steven Kelly

Research Profile

Chemicals & Drugs

Living Beings

Co-author Network

Publications

TOP 3
Elena C Calabrese; Lucia Calucci; Sabrina Castellano; Ilaria Granata; Steven L Kelly; David C Lamb; Bruno Maresca; Ciro Milite; Mike F Quartacci; Marisabella Santoriello; Gianluca Sbardella; Cristina Sgherri; Giorgio Stefancich; Andrew G S Warrilow; Amalia Porta
Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans.
Josie E Parker; Katarina Rigdova; Andrew G S Warrilow; John A Lucas; Hans J Cools; Bart A Fraaije; William J Griffiths; Diane E Kelly; Steven L Kelly
Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase.
Andrew G S Warrilow; Josie E Parker; Diane E Kelly; Steven L Kelly
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Steven Kelly (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Elena C Calabrese; Lucia Calucci; Sabrina Castellano; Ilaria Granata; Steven L Kelly; David C Lamb; Bruno Maresca; Ciro Milite; Mike F Quartacci; Marisabella Santoriello; Gianluca Sbardella; Cristina Sgherri; Giorgio Stefancich; Andrew G S Warrilow; Amalia Porta
Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans.
The Journal of antimicrobial chemotherapy 2013;68(5):1111-9.
2013: Josie E Parker; Katarina Rigdova; Andrew G S Warrilow; John A Lucas; Hans J Cools; Bart A Fraaije; William J Griffiths; Diane E Kelly; Steven L Kelly
Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase.
Applied and environmental microbiology 2013;79(5):1639-45.
2013: Andrew G S Warrilow; Josie E Parker; Diane E Kelly; Steven L Kelly
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
Antimicrobial agents and chemotherapy 2013;57(3):1352-60.
2013: Steven L Kelly; Diane E Kelly
Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1612):20120476.
2013: Alun W Newsome; Andrew Corran; Steven L Kelly; David Nelson; Diane E Kelly
The cytochrome P450 complement (CYPome) of Mycosphaerella graminicola.
Biotechnology and applied biochemistry 2013;60(1):52-64.
2012: Claire M Hull; Diane E Kelly; Oliver Bader; Uwe Gross; Josie E Parker; Andrew G S Warrilow; Michael Weig; Steven L Kelly
Two clinical isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2.
Antimicrobial agents and chemotherapy 2012;56(12):6417-21.
2012: Claire M Hull; Diane E Kelly; Oliver Bader; Uwe Gross; Josie E Parker; Andrew G S Warrilow; Michael Weig; Steven L Kelly
Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.
Antimicrobial agents and chemotherapy 2012;56(8):4223-32.
2012: Suzy C Moody; Jonathan G L Mullins; David R Nelson; Michael R Waterman; Bin Zhao; Steven L Kelly; Li Lei; David C Lamb
Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.
The FEBS journal 2012;279(9):1640-9.
2012: Andrew G S Warrilow; Claire M Hull; Diane E Kelly; David C Lamb; Jonathan G L Mullins; Josie E Parker; Steven L Kelly
S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.
Antimicrobial agents and chemotherapy 2012;56(4):2099-107.
2012: Bin Zhao; Robert C Hider; Steven L Kelly; Li Lei; Suzy C Moody; Michael R Waterman; David C Lamb
Structural Analysis of Cytochrome P450 105N1 Involved in the Biosynthesis of the Zincophore, Coelibactin.
International journal of molecular sciences 2012;13(7):8500-13.
2011: Hans J Cools; Jonathan G L Mullins; Bart A Fraaije; Josie E Parker; Diane E Kelly; John A Lucas; Steven L Kelly
Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity.
Applied and environmental microbiology 2011;77(11):3830-7.
2011: Josie E Parker; Andrew G S Warrilow; Hans J Cools; Claire M Martel; W David Nes; Bart A Fraaije; John A Lucas; Diane E Kelly; Steven L Kelly
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.
Applied and environmental microbiology 2011;77(4):1460-5.
2011: Jonathan G L Mullins; Josie E Parker; Roberto C Togawa; John A Lucas; Hans J Cools; Bart A Fraaije; Diane E Kelly; Steven L Kelly
Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola.
PloS one 2011;6(6):e20973.
2011: C M Martel; J E Parker; Colin J Jackson; Andrew G S Warrilow; N Rolley; C Greig; S M Morris; Iain S Donnison; Diane E Kelly; Steven L Kelly
Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol.
Bioresource technology 2011;102(2):1503-8.
2010: Qian Cheng; David C Lamb; Steven L Kelly; Li Lei; F Peter Guengerich
Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction.
Journal of the American Chemical Society 2010;132(43):15173-5.
2010: Claire M Martel; Josie E Parker; Andrew G S Warrilow; Nicola J Rolley; Steven L Kelly; Diane E Kelly
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.
Antimicrobial agents and chemotherapy 2010;54(11):4920-3.
2010: Claire M Martel; Josie E Parker; Oliver Bader; Michael Weig; Uwe Gross; Andrew G S Warrilow; Nicola Rolley; Diane E Kelly; Steven L Kelly
Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
Antimicrobial agents and chemotherapy 2010;54(11):4527-33.
2010: Andrew G S Warrilow; Nadja Melo; Claire M Martel; Josie E Parker; W David Nes; Steven L Kelly; Diane E Kelly
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.
Antimicrobial agents and chemotherapy 2010;54(10):4225-34.
2010: Andrew G S Warrilow; Claire M Martel; Josie E Parker; Nadja Melo; David C Lamb; W David Nes; Diane E Kelly; Steven L Kelly
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).
Antimicrobial agents and chemotherapy 2010;54(10):4235-45.
2010: Claire M Martel; Josie E Parker; Oliver Bader; Michael Weig; Uwe Gross; Andrew G S Warrilow; Diane E Kelly; Steven L Kelly
A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.
Antimicrobial agents and chemotherapy 2010;54(9):3578-83.
2010: David C Lamb; Li Lei; Bin Zhao; Hang Yuan; Colin J Jackson; Andrew G S Warrilow; Tove Skaug; Paul J Dyson; Eric S Dawson; Steven L Kelly; David L Hachey; Michael R Waterman
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner.
Applied and environmental microbiology 2010;76(6):1975-80.
2009: David C Lamb; Li Lei; Andrew G S Warrilow; Galina I Lepesheva; Jonathan G L Mullins; Michael R Waterman; Steven L Kelly
The first virally encoded cytochrome p450.
Journal of virology 2009;83(16):8266-9.
2009: Andrew G S Warrilow; Colin J Jackson; Josie E Parker; Timothy H Marczylo; Diane E Kelly; David C Lamb; Steven L Kelly
Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.
Antimicrobial agents and chemotherapy 2009;53(3):1157-64.
2009: Colin J Jackson; Richard C Barton; C Graham Clark; Steven L Kelly
Molecular characterization of a subgroup IE intron with wide distribution in the large subunit rRNA genes of dermatophyte fungi.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2009;47(6):609-17.
2008: Bin Zhao; Xin Lin; Li Lei; David C Lamb; Steven L Kelly; Michael R Waterman; David E Cane
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
The Journal of biological chemistry 2008;283(13):8183-9.
2007: David C Lamb; Michael R Waterman; Steven L Kelly; F Peter Guengerich
Cytochromes P450 and drug discovery.
Current opinion in biotechnology 2007;18(6):504-12.
2007: David C Lamb; Colin J Jackson; Andrew G S Warrilow; Nigel J Manning; Diane E Kelly; Steven L Kelly
Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis.
Molecular biology and evolution 2007;24(8):1714-21.
2007: Bin Zhao; David C Lamb; Li Lei; Steven L Kelly; Hang Yuan; David L Hachey; Michael R Waterman
Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2.
Biochemistry 2007;46(30):8725-33.
2007: Young-Jin Chun; Tsutomu Shimada; Raymundo Sanchez-Ponce; Martha V Martin; Li Lei; Bin Zhao; Steven L Kelly; Michael R Waterman; David C Lamb; F Peter Guengerich
Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2).
The Journal of biological chemistry 2007;282(24):17486-500.
2006: Mustak A Kaderbhai; Steven L Kelly; Naheed N Kaderbhai
Towards engineered topogenesis of cytochrome b(5) and P450 for in vivo transformation of xenobiotics.
Biochemical Society transactions 2006;34(Pt 6):1231-5.
2006: David C Lamb; F Peter Guengerich; Steven L Kelly; Michael R Waterman
Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery.
Expert opinion on drug metabolism & toxicology 2006;2(1):27-40.
2006: David C Lamb; Youngchang Kim; Liudmila V Yermalitskaya; Valery N Yermalitsky; Galina I Lepesheva; Steven L Kelly; Michael R Waterman; Larissa M Podust
A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.
Structure (London, England : 1993) 2006;14(1):51-61.
2005: M Kalim Akhtar; Steven L Kelly; Mustak A Kaderbhai
Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis.
The Journal of endocrinology 2005;187(2):267-74.
2005: Bin Zhao; F Peter Guengerich; Aouatef Bellamine; David C Lamb; Miho Izumikawa; Li Lei; Larissa M Podust; Munirathinam Sundaramoorthy; John A Kalaitzis; L Manmohan Reddy; Steven L Kelly; Bradley S Moore; Donald F Stec; Markus Voehler; John R Falck; Tsutomu Shimada; Michael R Waterman
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.
The Journal of biological chemistry 2005;280(12):11599-607.
2004: Li Lei; Michael R Waterman; Armand J Fulco; Steven L Kelly; David C Lamb
Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2).
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):494-9.
2004: Larissa M Podust; Horacio Bach; Youngchang Kim; David C Lamb; Miharu Arase; David H Sherman; Steven L Kelly; Michael R Waterman
Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways.
Protein science : a publication of the Protein Society 2004;13(1):255-68.
2003: M Kalim Akhtar; Naheed N Kaderbhai; David J Hopper; Steven L Kelly; Mustak A Kaderbhai
Export of a heterologous cytochrome P450 (CYP105D1) in Escherichia coli is associated with periplasmic accumulation of uroporphyrin.
The Journal of biological chemistry 2003;278(46):45555-62.
2003: Colin J Jackson; David C Lamb; Nigel J Manning; Diane E Kelly; Steven L Kelly
Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole.
Biochemical and biophysical research communications 2003;309(4):999-1004.
2003: Takashi Mochizuki; Hiroshi Ishizaki; Richard C Barton; Mary K Moore; Colin J Jackson; Steven L Kelly; E Glyn V Evans
Restriction fragment length polymorphism analysis of ribosomal DNA intergenic regions is useful for differentiating strains of Trichophyton mentagrophytes.
Journal of clinical microbiology 2003;41(10):4583-8.
2003: David C Lamb; Haruo Ikeda; David Nelson; Jun Ishikawa; Tove Skaug; Colin Jackson; Satoshi Omura; Michael R Waterman; Steven L Kelly
Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).
Biochemical and biophysical research communications 2003;307(3):610-9.
2003: Larissa M Podust; Youngchang Kim; Miharu Arase; Benjamin A Neely; Brian J Beck; Horacio Bach; David H Sherman; David C Lamb; Steven L Kelly; Michael R Waterman
The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems.
The Journal of biological chemistry 2003;278(14):12214-21.
2003: Colin J Jackson; David C Lamb; Timothy H Marczylo; Josie E Parker; Nigel L Manning; Diane E Kelly; Steven L Kelly
Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.
Biochemical and biophysical research communications 2003;301(2):558-63.
2003: Steven L Kelly; David C Lamb; Colin J Jackson; Andrew G S Warrilow; Diane E Kelly
The biodiversity of microbial cytochromes P450.
Advances in microbial physiology 2003;47():131-86.
2002: Colin J Jackson; David C Lamb; Timothy H Marczylo; Andrew G S Warrilow; Nigel J Manning; David J Lowe; Diane E Kelly; Steven L Kelly
A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily.
The Journal of biological chemistry 2002;277(49):46959-65.
2002: Andrew G S Warrilow; David C Lamb; Diane E Kelly; Steven L Kelly
Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism.
Biochemical and biophysical research communications 2002;299(2):189-95.
2002: David C Lamb; Tove Skaug; Hong-Lin Song; Colin J Jackson; Larissa M Podust; Michael R Waterman; Douglas B Kell; Diane E Kelly; Steven L Kelly
The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2).
The Journal of biological chemistry 2002;277(27):24000-5.
2002: David C Lamb; Kay Fowler; Tobias Kieser; Nigel J Manning; Larissa M Podust; Michael R Waterman; Diane E Kelly; Steven L Kelly
Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.
The Biochemical journal 2002;364(Pt 2):555-62.
2002: Philip Groeneveld; Nicola Rolley; Douglas B Kell; Steven L Kelly; Diane E Kelly
Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway.
Molecular biology reports 2002;29(1-2):27-9.
2001: David C Lamb; Naheed N Kaderbhai; K Venkateswarlu; Diane E Kelly; Steven L Kelly; Mustak A Kaderbhai
Human sterol 14alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5).
Archives of biochemistry and biophysics 2001;395(1):78-84.
2001: David C Lamb; Andrew G S Warrilow; K Venkateswarlu; Diane E Kelly; Steven L Kelly
Activities and kinetic mechanisms of native and soluble NADPH-cytochrome P450 reductase.
Biochemical and biophysical research communications 2001;286(1):48-54.
2001: David C Lamb; M Cannieux; Andrew G S Warrilow; S Bak; R A Kahn; Nigel J Manning; Diane E Kelly; Steven L Kelly
Plant sterol 14 alpha-demethylase affinity for azole fungicides.
Biochemical and biophysical research communications 2001;284(3):845-9.
2001: Steven L Kelly; David C Lamb; M Cannieux; D Greetham; C J Jackson; Timothy H Marczylo; CC Ugochukwu; Diane E Kelly
An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance.
Biochemical Society transactions 2001;29(Pt 2):122-8.
2001: Mustak A Kaderbhai; CC Ugochukwu; Steven L Kelly; David C Lamb
Export of cytochrome P450 105D1 to the periplasmic space of Escherichia coli.
Applied and environmental microbiology 2001;67(5):2136-8.
2000: Mustak A Kaderbhai; CC Ugochukwu; David C Lamb; Steven L Kelly
Targeting of active human cytochrome P4501A1 (CYP1A1) to the periplasmic space of Escherichia coli.
Biochemical and biophysical research communications 2000;279(3):803-7.
2000: M Taylor; D C Lamb; RJ Cannell; Michael J Dawson; Steven L Kelly
Cofactor recycling with immobilized heterologous cytochrome P450 105D1 (CYP105D1).
Biochemical and biophysical research communications 2000;279(2):708-11.
2000: Colin J Jackson; Richard C Barton; Steven L Kelly; E Glyn V Evans
Strain identification of Trichophyton rubrum by specific amplification of subrepeat elements in the ribosomal DNA nontranscribed spacer.
Journal of clinical microbiology 2000;38(12):4527-34.
2000: C J Jackson; David C Lamb; Diane E Kelly; Steven L Kelly
Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.
FEMS microbiology letters 2000;192(2):159-62.
2000: David C Lamb; Diane E Kelly; B C Baldwin; Steven L Kelly
Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents.
Chemico-biological interactions 2000;125(3):165-75.
2000: David C Lamb; Diane E Kelly; T C White; Steven L Kelly
The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.
Antimicrobial agents and chemotherapy 2000;44(1):63-7.
1999: S Maspahy; David C Lamb; Steven L Kelly
Purification and characterization of a benzo[a]pyrene hydroxylase from Pleurotus pulmonarius.
Biochemical and biophysical research communications 1999;266(2):326-9.
1999: David C Lamb; Diane E Kelly; Nigel J Manning; Mustak A Kaderbhai; Steven L Kelly
Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.
FEBS letters 1999;462(3):283-8.
1999: Steven L Kelly; David C Lamb; Diane E Kelly
Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem.
FEMS microbiology letters 1999;180(2):171-5.
1999: M Taylor; David C Lamb; RJ Cannell; M Dawson; Steven L Kelly
Cytochrome P450105D1 (CYP105D1) from Streptomyces griseus: heterologous expression, activity, and activation effects of multiple xenobiotics.
Biochemical and biophysical research communications 1999;263(3):838-42.
1999: Steven L Kelly; David C Lamb; J Loeffler; H Einsele; Diane E Kelly
The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.
Biochemical and biophysical research communications 1999;262(1):174-9.
1999: David C Lamb; Diane E Kelly; K Venkateswarlu; Nigel J Manning; H F Bligh; W H Schunck; Steven L Kelly
Generation of a complete, soluble, and catalytically active sterol 14 alpha-demethylase-reductase complex.
Biochemistry 1999;38(27):8733-8.
1999: David C Lamb; S Maspahy; Diane E Kelly; Nigel J Manning; A Geber; JOHN BENNETT; Steven L Kelly
Purification, reconstitution, and inhibition of cytochrome P-450 sterol delta22-desaturase from the pathogenic fungus Candida glabrata.
Antimicrobial agents and chemotherapy 1999;43(7):1725-8.
1999: David C Lamb; Diane E Kelly; Michael R Waterman; M Stromstedt; Damjana Rozman; Steven L Kelly
Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.
Yeast (Chichester, England) 1999;15(9):755-63.
1998: David C Lamb; Diane E Kelly; Nigel J Manning; D W Hollomon; Steven L Kelly
Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14 alpha-demethylase (CYP51; P450(14DM)).
FEMS microbiology letters 1998;169(2):369-73.
1998: David C Lamb; Diane E Kelly; Nigel J Manning; Steven L Kelly
A sterol biosynthetic pathway in Mycobacterium.
FEBS letters 1998;437(1-2):142-4.
1998: K Venkateswarlu; Diane E Kelly; Nigel J Manning; Steven L Kelly
NADPH cytochrome P-450 oxidoreductase and susceptibility to ketoconazole.
Antimicrobial agents and chemotherapy 1998;42(7):1756-61.
1998: David C Lamb; Diane E Kelly; Steven L Kelly
Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans.
FEBS letters 1998;425(2):263-5.
1998: David C Lamb; Diane E Kelly; S Z Hanley; Z Mehmood; Steven L Kelly
Glyphosate is an inhibitor of plant cytochrome P450: functional expression of Thlaspi arvensae cytochrome P45071B1/reductase fusion protein in Escherichia coli.
Biochemical and biophysical research communications 1998;244(1):110-4.
1998: K Venkateswarlu; David C Lamb; Diane E Kelly; Nigel J Manning; Steven L Kelly
The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity.
The Journal of biological chemistry 1998;273(8):4492-6.
1997: Steven L Kelly; David C Lamb; Diane E Kelly
Sterol 22-desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism.
FEBS letters 1997;412(1):233-5.
1997: David C Lamb; B C Baldwin; K J Kwon-Chung; Steven L Kelly
Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1997;41(7):1465-7.
1997: K Venkateswarlu; David W Denning; Steven L Kelly
In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei.
The Journal of antimicrobial chemotherapy 1997;39(6):731-6.
1997: David W Denning; K Venkateswarlu; KL Oakley; M J Anderson; Nigel J Manning; D A Stevens; DW Warnock; Steven L Kelly
Itraconazole resistance in Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 1997;41(6):1364-8.
1997: K Venkateswarlu; Steven L Kelly
Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus.
The Journal of antimicrobial chemotherapy 1997;39(5):597-601.
1997: Steven L Kelly; David C Lamb; BC Baldwin; A J Corran; Diane E Kelly
Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents.
The Journal of biological chemistry 1997;272(15):9986-8.
1997: David C Lamb; Diane E Kelly; BC Baldwin; F Gozzo; P Boscott; W G Richards; Steven L Kelly
Differential inhibition of Candida albicans CYP51 with azole antifungal stereoisomers.
FEMS microbiology letters 1997;149(1):25-30.
1997: K Venkateswarlu; Diane E Kelly; Steven L Kelly
Characterization of Saccharomyces cerevisiae CYP51 and a CYP51 fusion protein with NADPH cytochrome P-450 oxidoreductase expressed in Escherichia coli.
Antimicrobial agents and chemotherapy 1997;41(4):776-80.
1997: K Venkateswarlu; M Taylor; Nigel J Manning; M G Rinaldi; Steven L Kelly
Fluconazole tolerance in clinical isolates of Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1997;41(4):748-51.
1997: David C Lamb; Diane E Kelly; W H Schunck; A Z Shyadehi; M Akhtar; D J Lowe; BC Baldwin; Steven L Kelly
The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity.
The Journal of biological chemistry 1997;272(9):5682-8.
1997: David C Lamb; Diane E Kelly; Nigel J Manning; Steven L Kelly
Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363.
FEMS microbiology letters 1997;147(2):189-93.
1997: Steven L Kelly; David C Lamb; Diane E Kelly; Nigel J Manning; J Loeffler; H Hebart; U Schumacher; H Einsele
Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation.
FEBS letters 1997;400(1):80-2.
1997: K Venkateswarlu; David W Denning; Steven L Kelly
Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1997;35(1):19-25.
1996: Steven L Kelly; David C Lamb; Diane E Kelly; Juergen Loeffler; Hermann Einsele
Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients.
Lancet 1996;348(9040):1523-4.
1996: K Venkateswarlu; Steven L Kelly
Biochemical characterisation of ketoconazole inhibitory action on Aspergillus fumigatus.
FEMS immunology and medical microbiology 1996;16(1):11-20.
1996: K Venkateswarlu; David W Denning; Nigel J Manning; Steven L Kelly
Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance.
Antimicrobial agents and chemotherapy 1996;40(11):2443-6.
1996: Z Mehmood; M P Williamson; Diane E Kelly; Steven L Kelly
Metabolism of organochlorine pesticides: the role of human cytochrome P450 3A4.
Chemosphere 1996;33(4):759-69.
1996: Timothy Joseph-Horne; R S Loeffler; Derek W Hollomon; Steven L Kelly
Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1996;34(3):223-5.
1996: K Venkateswarlu; David W Denning; Nigel J Manning; Steven L Kelly
Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.
Antimicrobial agents and chemotherapy 1996;40(6):1382-6.
1996: A Z Shyadehi; David C Lamb; Steven L Kelly; Diane E Kelly; W H Schunck; J Neville Wright; D Corina; M Akhtar
The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51).
The Journal of biological chemistry 1996;271(21):12445-50.
1996: Michael A Quail; Steven L Kelly
The extraction and analysis of sterols from yeast.
Methods in molecular biology (Clifton, N.J.) 1996;53():123-31.
1995: Steven L Kelly; David C Lamb; A J Corran; B C Baldwin; L W Parks; Diane E Kelly
Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol delta 22-desaturase.
FEBS letters 1995;377(2):217-20.
1995: Z Mehmood; Diane E Kelly; Steven L Kelly
Metabolism of the herbicide chlortoluron by human cytochrome P450 3A4.
Chemosphere 1995;31(11-12):4515-29.
1995: Timothy Joseph-Horne; Derek W Hollomon; R S Loeffler; Steven L Kelly
Altered P450 activity associated with direct selection for fungal azole resistance.
FEBS letters 1995;374(2):174-8.
1995: K Venkateswarlu; David W Denning; Nigel J Manning; Steven L Kelly
Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug.
FEMS microbiology letters 1995;131(3):337-41.
1995: David C Lamb; A Corran; B C Baldwin; J Kwon-Chung; Steven L Kelly
Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients.
FEBS letters 1995;368(2):326-30.
1995: Timothy Joseph-Horne; Derek W Hollomon; R S Loeffler; Steven L Kelly
Cross-resistance to polyene and azole drugs in Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1995;39(7):1526-9.
1995: Timothy Joseph-Horne; Nigel J Manning; Derek W Hollomon; Steven L Kelly
Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.
FEMS microbiology letters 1995;127(1-2):29-34.
1995: Steven L Kelly; David C Lamb; A J Corran; B C Baldwin; Diane E Kelly
Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.
Biochemical and biophysical research communications 1995;207(3):910-5.
1994: Diane E Kelly; M E Rose; Steven L Kelly
Investigation of the role of sterol delta 8-->7-isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph.
FEMS microbiology letters 1994;122(3):223-6.
1994: Steven L Kelly; David C Lamb; M Taylor; A J Corran; B C Baldwin; W G Powderly
Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.
FEMS microbiology letters 1994;122(1-2):39-42.
1994: Steven L Kelly; S Kenna; A Arnoldi; Diane E Kelly
Studies on azole-induced cell death in Saccharomyces cerevisiae.
FEMS microbiology letters 1994;115(2-3):219-22.
1993: Steven L Kelly; David C Lamb; B C Baldwin; Diane E Kelly
Benzo(a)pyrene hydroxylase activity in yeast is mediated by P450 other than sterol 14 alpha-demethylase.
Biochemical and biophysical research communications 1993;197(2):428-32.
1993: Steven L Kelly; A Arnoldi; Diane E Kelly
Molecular genetic analysis of azole antifungal mode of action.
Biochemical Society transactions 1993;21(4):1034-8.
1993: Steven L Kelly
P-450 biotechnology.
Biochemical Society transactions 1993;21(4):1015-7.
1991: Steven L Kelly; J Rowe; P F Watson
Molecular genetic studies on the mode of action of azole antifungal agents.
Biochemical Society transactions 1991;19(3):796-8.
1989: S Kenna; H F Bligh; P F Watson; Steven L Kelly
Genetic and physiological analysis of azole sensitivity in Saccharomyces cerevisiae.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1989;27(6):397-406.
1988: P F Watson; M E Rose; Steven L Kelly
Isolation and analysis of ketoconazole resistant mutants of Saccharomyces cerevisiae.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1988;26(3):153-62.