Thomas Kensler

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Reddy Narsa M; Suryanaraya Vegiraju; Yates Melinda S; Kleeberger Steven R; Hassoun Paul M; Yamamoto Masayuki; Liby Karen T; Sporn Michael B; Kensler Thomas W; Reddy Sekhar P
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
Reddy Narsa M; Suryanarayana Vegiraju; Kalvakolanu Dhananjaya V; Yamamoto Masayuki; Kensler Thomas W; Hassoun Paul M; Kleeberger Steven R; Reddy Sekhar P
Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice.
Shin Soona; Wakabayashi Junko; Yates Melinda S; Wakabayashi Nobunao; Dolan Patrick M; Aja Susan; Liby Karen T; Sporn Michael B; Yamamoto Masayuki; Kensler Thomas W
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide.

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2009: Reddy Narsa M; Suryanaraya Vegiraju; Yates Melinda S; Kleeberger Steven R; Hassoun Paul M; Yamamoto Masayuki; Liby Karen T; Sporn Michael B; Kensler Thomas W; Reddy Sekhar P
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
American journal of respiratory and critical care medicine 2009;180(9):867-74.
2009: Reddy Narsa M; Suryanarayana Vegiraju; Kalvakolanu Dhananjaya V; Yamamoto Masayuki; Kensler Thomas W; Hassoun Paul M; Kleeberger Steven R; Reddy Sekhar P
Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4601-8.
2009: Shin Soona; Wakabayashi Junko; Yates Melinda S; Wakabayashi Nobunao; Dolan Patrick M; Aja Susan; Liby Karen T; Sporn Michael B; Yamamoto Masayuki; Kensler Thomas W
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide.
European journal of pharmacology 2009;620(1-3):138-44.
2009: Usera Aimee R; Dolan Patrick; Kensler Thomas W; Posner Gary H
'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.
Bioorganic & medicinal chemistry 2009;17(15):5627-31.
2009: Nagai Norihiro; Thimmulappa Rajesh K; Cano Marisol; Fujihara Masashi; Izumi-Nagai Kanako; Kong Xiaoni; Sporn Michael B; Kensler Thomas W; Biswal Shyam; Handa James T
Nrf2 is a critical modulator of the innate immune response in a model of uveitis.
Free radical biology & medicine 2009;47(3):300-6.
2009: Reddy Narsa M; Kleeberger Steven R; Kensler Thomas W; Yamamoto Masayuki; Hassoun Paul M; Reddy Sekhar P
Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):7264-71.
2009: Yates Melinda S; Tran Quynh T; Dolan Patrick M; Osburn William O; Shin Soona; McCulloch Colin C; Silkworth Jay B; Taguchi Keiko; Yamamoto Masayuki; Williams Charlotte R; Liby Karen T; Sporn Michael B; Sutter Thomas R; Kensler Thomas W
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Carcinogenesis 2009;30(6):1024-31.
2009: An Steven S; Kim Jina; Ahn Kwangmi; Trepat Xavier; Drake Kenneth J; Kumar Sarvesh; Ling Guoyu; Purington Carolyn; Rangasamy Tirumalai; Kensler Thomas W; Mitzner Wayne; Fredberg Jeffrey J; Biswal Shyam
Cell stiffness, contractile stress and the role of extracellular matrix.
Biochemical and biophysical research communications 2009;382(4):697-703.
2009: Roebuck Bill D; Johnson Denise N; Sutter Carrie Hayes; Egner Patricia A; Scholl Peter F; Friesen Marlin D; Baumgartner Karen J; Ware Nicholas M; Bodreddigari Sridevi; Groopman John D; Kensler Thomas W; Sutter Thomas R
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):41-9.
2009: Blackford Amanda; Parmigiani Giovanni; Kensler Thomas W; Wolfgang Christopher; Jones Siân; Zhang Xiaosong; Parsons D Willams; Lin Jimmy Cheng-Ho; Leary Rebecca J; Eshleman James R; Goggins Michael; Jaffee Elizabeth M; Iacobuzio-Donahue Christine A; Maitra Anirban; Klein Alison; Cameron John L; Olino Kelly; Schulick Richard; Winter Jordan; Vogelstein Bert; Velculescu Victor E; Kinzler Kenneth W; Hruban Ralph H
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Cancer research 2009;69(8):3681-8.
2009: Tran Quynh T; Xu Lijing; Phan Vinhthuy; Goodwin Shirlean B; Rahman Mostafizur; Jin Victor X; Sutter Carrie H; Roebuck Bill D; Kensler Thomas W; George E Olusegun; Sutter Thomas R
Chemical genomics of cancer chemopreventive dithiolethiones.
Carcinogenesis 2009;30(3):480-6.
2009: Singh Anju; Ling Guoyu; Suhasini Avvaru N; Zhang Ping; Yamamoto Masayuki; Navas-Acien Ana; Cosgrove Gregory; Tuder Rubin M; Kensler Thomas W; Watson Walter H; Biswal Shyam
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs.
Free radical biology & medicine 2009;46(3):376-86.
2009: Sussan Thomas E; Rangasamy Tirumalai; Blake David J; Malhotra Deepti; El-Haddad Hazim; Bedja Djahida; Yates Melinda S; Kombairaju Ponvijay; Yamamoto Masayuki; Liby Karen T; Sporn Michael B; Gabrielson Kathleen L; Champion Hunter C; Tuder Rubin M; Kensler Thomas W; Biswal Shyam
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):250-5.
2008: Williams Marc A; Rangasamy Tirumalai; Bauer Stephen M; Killedar Smruti; Karp Matthew; Kensler Thomas W; Yamamoto Masayuki; Breysse Patrick; Biswal Shyam; Georas Steve N
Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4545-59.
2008: Egner Patricia A; Kensler Thomas W; Chen Jian-Guo; Gange Stephen J; Groopman John D; Friesen Marlin D
Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.
Chemical research in toxicology 2008;21(10):1991-6.
2008: Reddy N M; Kleeberger S R; Bream J H; Fallon P G; Kensler T W; Yamamoto M; Reddy S P
Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling.
Oncogene 2008;27(44):5821-32.
2008: Colburn Nancy H; Kensler Thomas W
Targeting transcription factors for cancer prevention--the case of Nrf2.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):153-5.
2008: Liby Karen; Yore Mark M; Roebuck Bill D; Baumgartner Karen J; Honda Tadashi; Sundararajan Chitra; Yoshizawa Hidenori; Gribble Gordon W; Williams Charlotte R; Risingsong Renee; Royce Darlene B; Dinkova-Kostova Albena T; Stephenson Katherine K; Egner Patricia A; Yates Melinda S; Groopman John D; Kensler Thomas W; Sporn Michael B
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Cancer research 2008;68(16):6727-33.
2008: Bransfield Leslie A; Rennie Alissa; Visvanathan Kala; Odwin Shelly-Ann; Kensler Thomas W; Yager James D; Friesen Marlin D; Groopman John D
Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine.
Chemical research in toxicology 2008;21(8):1622-30.
2008: Osburn William O; Yates Melinda S; Dolan Patrick D; Chen Sining; Liby Karen T; Sporn Michael B; Taguchi Keiko; Yamamoto Masayuki; Kensler Thomas W
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(1):218-27.
2008: Osburn William O; Kensler Thomas W
Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults.
Mutation research 2008;659(1-2):31-9.
2008: Chu Haitao; Nie Lei; Kensler Thomas W
A Bayesian approach estimating treatment effects on biomarkers containing zeros with detection limits.
Statistics in medicine 2008;27(13):2497-508.
2008: Bodreddigari Sridevi; Jones Laundette Knight; Egner Patricia A; Groopman John D; Sutter Carrie Hayes; Roebuck Bill D; Guengerich F Peter; Kensler Thomas W; Sutter Thomas R
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.
Chemical research in toxicology 2008;21(5):1134-42.
2008: Johnson Denise N; Egner Patricia A; Obrian Greg; Glassbrook Norman; Roebuck Bill D; Sutter Thomas R; Payne Gary A; Kensler Thomas W; Groopman John D
Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry.
Chemical research in toxicology 2008;21(3):752-60.
2008: Pearson Kevin J; Lewis Kaitlyn N; Price Nathan L; Chang Joy W; Perez Evelyn; Cascajo Maria Victoria; Tamashiro Kellie L; Poosala Suresh; Csiszar Anna; Ungvari Zoltan; Kensler Thomas W; Yamamoto Masayuki; Egan Josephine M; Longo Dan L; Ingram Donald K; Navas Placido; de Cabo Rafael
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2325-30.
2008: Groopman John D; Kensler Thomas W; Wild Christopher P
Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries.
Annual review of public health 2008;29():187-203.
2007: Papaiahgari Srinivas; Yerrapureddy Adi; Reddy Swetha R; Reddy Narsa M; Dodd-O Jeffery M; Crow Michael T; Grigoryev Dimitry N; Barnes Kathleen; Tuder Rubin M; Yamamoto Masayuki; Kensler Thomas W; Biswal Shyam; Mitzner Wayne; Hassoun Paul M; Reddy Sekhar P
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice.
American journal of respiratory and critical care medicine 2007;176(12):1222-35.
2007: Reddy Narsa M; Kleeberger Steven R; Yamamoto Masayuki; Kensler Thomas W; Scollick Catherine; Biswal Shyam; Reddy Sekhar P
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection.
Physiological genomics 2007;32(1):74-81.
2007: Manandhar Sarala; Cho Jeong-Min; Kim Jung-Ae; Kensler Thomas W; Kwak Mi-Kyoung
Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.
European journal of pharmacology 2007;577(1-3):17-27.
2007: Petersen Kimberly S; Dolan Patrick M; Kensler Thomas W; Peleg Sara; Posner Gary H
Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.
Journal of medicinal chemistry 2007;50(23):5824-32.
2007: Thimmulappa Rajesh K; Fuchs Ralph J; Malhotra Deepti; Scollick Catherine; Traore Kassim; Bream Jay H; Trush Michael A; Liby Karen T; Sporn Michael B; Kensler Thomas W; Biswal Shyam
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Antioxidants & redox signaling 2007;9(11):1963-70.
2007: Osburn William O; Karim Baktiar; Dolan Patrick M; Liu Guosheng; Yamamoto Masayuki; Huso David L; Kensler Thomas W
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment.
International journal of cancer. Journal international du cancer 2007;121(9):1883-91.
2007: Shin Soona; Wakabayashi Nobunao; Misra Vikas; Biswal Shyam; Lee Gum Hwa; Agoston Elin S; Yamamoto Masayuki; Kensler Thomas W
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis.
Molecular and cellular biology 2007;27(20):7188-97.
2007: Yates Melinda Sue; Kensler Thomas Wells
Keap1 eye on the target: chemoprevention of liver cancer.
Acta pharmacologica Sinica 2007;28(9):1331-42.
2007: Kwak Mi-Kyoung; Cho Jeong-Min; Huang Bo; Shin Soona; Kensler Thomas W
Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells.
Free radical biology & medicine 2007;43(5):809-17.
2007: Wang Jian; Fields Jocelyn; Zhao Chunying; Langer John; Thimmulappa Rajesh K; Kensler Thomas W; Yamamoto Masayuki; Biswal Shyam; Doré Sylvain
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice.
Free radical biology & medicine 2007;43(3):408-14.
2007: Usera Aimee R; Dolan Patrick M; Kensler Thomas W; Posner Gary H
Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1alpha,25-dihydroxyvitamin D3: chemical synthesis and biological evaluation.
Bioorganic & medicinal chemistry 2007;15(16):5509-18.
2007: Reddy Narsa M; Kleeberger Steven R; Cho Hye-Youn; Yamamoto Masayuki; Kensler Thomas W; Biswal Shyam; Reddy Sekhar P
Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants.
American journal of respiratory cell and molecular biology 2007;37(1):3-8.
2007: Cornblatt Brian S; Ye Lingxiang; Dinkova-Kostova Albena T; Erb Melanie; Fahey Jed W; Singh Navin K; Chen Min-Shue A; Stierer Tracey; Garrett-Mayer Elizabeth; Argani Pedram; Davidson Nancy E; Talalay Paul; Kensler Thomas W; Visvanathan Kala
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.
Carcinogenesis 2007;28(7):1485-90.
2007: Chen Jian Guo; Kuang Shuang Yuan; Egner Patricia A; Lu Jian Hua; Zhu Yuan Rong; Wang Jin Bing; Zhang Bao Chu; Chen Tao Yang; Muñoz Alvaro; Kensler Thomas W; Groopman John D
Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1213-8.
2007: Kwak Mi-Kyoung; Huang Bo; Chang Hanna; Kim Jung-Ae; Kensler Thomas W
Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein.
Life sciences 2007;80(26):2411-20.
2007: Shah Z A; Li R-C; Thimmulappa R K; Kensler T W; Yamamoto M; Biswal S; Doré S
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury.
Neuroscience 2007;147(1):53-9.
2007: Simonich Michael T; Egner Patricia A; Roebuck Bill D; Orner Gayle A; Jubert Carole; Pereira Cliff; Groopman John D; Kensler Thomas W; Dashwood Roderick H; Williams David E; Bailey George S
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
Carcinogenesis 2007;28(6):1294-302.
2007: Fahey Jed W; Kensler Thomas W
Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes.
Chemical research in toxicology 2007;20(4):572-6.
2007: Yates Melinda S; Kensler Thomas W
Chemopreventive promise of targeting the Nrf2 pathway.
Drug news & perspectives 2007;20(2):109-17.
2007: Posner Gary H; Suh Byung Chul; Petersen Kimberly S; Dolan Patrick; Agoston Elin S; Kensler Thomas W; Koh John T; Peleg Sara
Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):213-21.
2007: Pratt M Margaret; Reddy Ashok P; Hendricks Jerry D; Pereira Cliff; Kensler Thomas W; Bailey George S
The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome.
Carcinogenesis 2007;28(3):611-24.
2007: Gong Jiachang; Vaidyanathan V G; Yu Xiang; Kensler Thomas W; Peterson Lisa A; Sturla Shana J
Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent.
Journal of the American Chemical Society 2007;129(7):2101-11.
2007: Yates Melinda S; Tauchi Masafumi; Katsuoka Fumiki; Flanders Kathleen C; Liby Karen T; Honda Tadashi; Gribble Gordon W; Johnson Delinda A; Johnson Jeffrey A; Burton Neal C; Guilarte Tomás R; Yamamoto Masayuki; Sporn Michael B; Kensler Thomas W
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
Molecular cancer therapeutics 2007;6(1):154-62.
2007: Mas Sergi; Crescenti Anna; Gassó Patricia; Deulofeu Ramon; Molina Rafael; Ballesta Antonio; Kensler Thomas W; Lafuente Amalia
Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea.
Nutrition and cancer 2007;58(1):107-14.
2007: Kensler Thomas W; Wakabayashi Nobunao; Biswal Shyam
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
Annual review of pharmacology and toxicology 2007;47():89-116.
2006: Peleg Sara; Petersen Kimberly S; Suh Byung Chul; Dolan Patrick; Agoston Elin S; Kensler Thomas W; Posner Gary H
Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.
Journal of medicinal chemistry 2006;49(25):7513-7.
2006: Thimmulappa Rajesh K; Scollick Catherine; Traore Kassim; Yates Melinda; Trush Michael A; Liby Karen T; Sporn Michael B; Yamamoto Masayuki; Kensler Thomas W; Biswal Shyam
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
Biochemical and biophysical research communications 2006;351(4):883-9.
2006: Burton Neal C; Kensler Thomas W; Guilarte Tomás R
In vivo modulation of the Parkinsonian phenotype by Nrf2.
Neurotoxicology 2006;27(6):1094-100.
2006: Singh Anju; Rangasamy Tirumalai; Thimmulappa Rajesh K; Lee Hannah; Osburn William O; Brigelius-Flohé Regina; Kensler Thomas W; Yamamoto Masayuki; Biswal Shyam
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2.
American journal of respiratory cell and molecular biology 2006;35(6):639-50.
2006: Osburn William O; Wakabayashi Nobunao; Misra Vikas; Nilles Tricia; Biswal Shyam; Trush Michael A; Kensler Thomas W
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion.
Archives of biochemistry and biophysics 2006;454(1):7-15.
2006: Egner Patricia A; Groopman John D; Wang Jia-Sheng; Kensler Thomas W; Friesen Marlin D
Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry.
Chemical research in toxicology 2006;19(9):1191-5.
2006: Glintborg Bente; Weimann Allan; Kensler Thomas W; Poulsen Henrik E
Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers.
Free radical biology & medicine 2006;41(6):1010-4.
2006: Yu Xiang; Egner Patricia A; Wakabayashi Junko; Wakabayashi Nobunao; Yamamoto Masayuki; Kensler Thomas W
Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase.
The Journal of biological chemistry 2006;281(36):26245-52.
2006: Sinishtaj Sandra; Jeon Heung Bae; Dolan Patrick; Kensler Thomas W; Posner Gary H
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
Bioorganic & medicinal chemistry 2006;14(18):6341-8.
2006: Skipper Paul L; Trudel Laura J; Kensler Thomas W; Groopman John D; Egner Patricia A; Liberman Rosa G; Wogan Gerald N; Tannenbaum Steven R
DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice.
Chemical research in toxicology 2006;19(8):1086-90.
2006: Kwak Mi-Kyoung; Kensler Thomas W
Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway.
Biochemical and biophysical research communications 2006;345(4):1350-7.
2006: Gong Jiachang; Neels James F; Yu Xiang; Kensler Thomas W; Peterson Lisa A; Sturla Shana J
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
Journal of medicinal chemistry 2006;49(8):2593-9.
2006: Thimmulappa Rajesh K; Lee Hannah; Rangasamy Tirumalai; Reddy Sekhar P; Yamamoto Masayuki; Kensler Thomas W; Biswal Shyam
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
The Journal of clinical investigation 2006;116(4):984-95.
2006: Karuri Asok R; Huang Yong; Bodreddigari Sridevi; Sutter Carrie Hayes; Roebuck Bill D; Kensler Thomas W; Sutter Thomas R
3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats.
The Journal of pharmacology and experimental therapeutics 2006;317(1):61-7.
2006: Yates Melinda S; Kwak Mi-Kyoung; Egner Patricia A; Groopman John D; Bodreddigari Sridevi; Sutter Thomas R; Baumgartner Karen J; Roebuck B D; Liby Karen T; Yore Mark M; Honda Tadashi; Gribble Gordon W; Sporn Michael B; Kensler Thomas W
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
Cancer research 2006;66(4):2488-94.
2006: Agoston E S; Hatcher M A; Kensler T W; Posner G H
Vitamin D analogs as anti-carcinogenic agents.
Anti-cancer agents in medicinal chemistry 2006;6(1):53-71.
2006: Scholl Peter F; McCoy Les; Kensler Thomas W; Groopman John D
Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometry.
Chemical research in toxicology 2006;19(1):44-9.
2006: Huang Yong; Yan Jian; Lubet Ronald; Kensler Thomas W; Sutter Thomas R
Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione.
Physiological genomics 2006;24(2):144-53.
2006: Okawa Hiromi; Motohashi Hozumi; Kobayashi Akira; Aburatani Hiroyuki; Kensler Thomas W; Yamamoto Masayuki
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.
Biochemical and biophysical research communications 2006;339(1):79-88.
2005: Cutler Richard; Guarante L P; Kensler Thomas W; Naftolin Fred; Jones Dean P; Cantor Charles R; Martin George M
Longevity determinant genes: what is the evidence? What's the importance? Panel discussion.
Annals of the New York Academy of Sciences 2005;1055():58-63.
2005: Dinkova-Kostova Albena T; Holtzclaw W David; Kensler Thomas W
The role of Keap1 in cellular protective responses.
Chemical research in toxicology 2005;18(12):1779-91.
2005: Yu Xiang; Kensler Thomas
Nrf2 as a target for cancer chemoprevention.
Mutation research 2005;591(1-2):93-102.
2005: Kensler Thomas W; Chen Jian-Guo; Egner Patricia A; Fahey Jed W; Jacobson Lisa P; Stephenson Katherine K; Ye Lingxiang; Coady Jamie L; Wang Jin-Bing; Wu Yan; Sun Yan; Zhang Qi-Nan; Zhang Bao-Chu; Zhu Yuan-Rong; Qian Geng-Sun; Carmella Stephen G; Hecht Stephen S; Benning Lorie; Gange Stephen J; Groopman John D; Talalay Paul
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(11 Pt 1):2605-13.
2005: Posner Gary H; Kim Hyung Jin; Kahraman Mehmet; Jeon Heung Bae; Suh Byung Chul; Li Hongbin; Dolan Patrick; Kensler Thomas W
Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
Bioorganic & medicinal chemistry 2005;13(19):5569-80.
2005: Healy Zachary R; Lee Norman H; Gao Xiangqun; Goldring Mary B; Talalay Paul; Kensler Thomas W; Konstantopoulos Konstantinos
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):14010-5.
2005: Groopman John D; Kensler Thomas W
Role of metabolism and viruses in aflatoxin-induced liver cancer.
Toxicology and applied pharmacology 2005;206(2):131-7.
2005: Rangasamy Tirumalai; Guo Jia; Mitzner Wayne A; Roman Jessica; Singh Anju; Fryer Allison D; Yamamoto Masayuki; Kensler Thomas W; Tuder Rubin M; Georas Steve N; Biswal Shyam
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice.
The Journal of experimental medicine 2005;202(1):47-59.
2005: Chu Haitao; Kensler Thomas W; Muñoz Alvaro
Assessing the effect of interventions in the context of mixture distributions with detection limits.
Statistics in medicine 2005;24(13):2053-67.
2005: Fahey Jed W; Stephenson Katherine K; Dinkova-Kostova Albena T; Egner Patricia A; Kensler Thomas W; Talalay Paul
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
Carcinogenesis 2005;26(7):1247-55.
2005: Hatcher Mark A; Peleg Sara; Dolan Patrick; Kensler Thomas W; Sarjeant Amy; Posner Gary H
A-ring hydroxymethyl 19-nor analogs of the natural hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
Bioorganic & medicinal chemistry 2005;13(12):3964-76.
2005: Posner Gary H; Lee S H Tony; Kim Hyung Jin; Peleg Sara; Dolan Patrick; Kensler Thomas W
Novel A-ring analogs of the hormone 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation.
Bioorganic & medicinal chemistry 2005;13(8):2959-66.
2005: Groopman John D; Johnson Denise; Kensler Thomas W
Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk.
Cancer biomarkers : section A of Disease markers 2005;1(1):5-14.
2005: Laso Nuria; Mas Sergi; Lafuente M Jose; Llobet Joan M; Molina Rafael; Ballesta Antonio; Kensler Thomas W; Lafuente Amalia
Induction of NAD(P)H quinone oxidoreductase by vegetables widely consumed in Catalonia, Spain.
Nutrition and cancer 2005;52(1):49-58.
2004: Kahraman Mehmet; Sinishtaj Sandra; Dolan Patrick M; Kensler Thomas W; Peleg Sara; Saha Uttam; Chuang Samuel S; Bernstein Galina; Korczak Bozena; Posner Gary H
Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).
Journal of medicinal chemistry 2004;47(27):6854-63.
2004: Anderson Steven P; Howroyd Paul; Liu Jie; Qian Xun; Bahnemann Rainer; Swanson Cynthia; Kwak Mi-Kyoung; Kensler Thomas W; Corton J Christopher
The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes.
The Journal of biological chemistry 2004;279(50):52390-8.
2004: Rangasamy Tirumalai; Cho Chung Y; Thimmulappa Rajesh K; Zhen Lijie; Srisuma Sorachai S; Kensler Thomas W; Yamamoto Masayuki; Petrache Irina; Tuder Rubin M; Biswal Shyam
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.
The Journal of clinical investigation 2004;114(9):1248-59.
2004: Kensler Thomas W; Egner Patricia A; Wang Jin-Bing; Zhu Yuan-Rong; Zhang Bao-Chu; Lu Pei-Xin; Chen Jian-Guo; Qian Geng-Sun; Kuang Shuang-Yuan; Jackson Peta E; Gange Stephen J; Jacobson Lisa P; Muñoz Alvaro; Groopman John D
Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas.
Gastroenterology 2004;127(5 Suppl 1):S310-8.
2004: Kwak Mi-Kyoung; Wakabayashi Nobunao; Kensler Thomas W
Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers.
Mutation research 2004;555(1-2):133-48.
2004: Posner Gary H; Jeon Heung Bae; Sarjeant Amy; Riccio Edward S; Doppalapudi Rupa S; Kapetanovic Izet M; Saha Uttam; Dolan Patrick; Kensler Thomas W
Low-calcemic, efficacious, 1alpha,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry.
Steroids 2004;69(11-12):757-62.
2004: Corton J Christopher; Apte Udayan; Anderson Steven P; Limaye Pallavi; Yoon Lawrence; Latendresse John; Dunn Corrie; Everitt Jeffrey I; Voss Kenneth A; Swanson Cynthia; Kimbrough Carie; Wong Jean S; Gill Sarjeet S; Chandraratna Roshantha A S; Kwak Mi-Kyoung; Kensler Thomas W; Stulnig Thomas M; Steffensen Knut R; Gustafsson Jan-Ake; Mehendale Harihara M
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
The Journal of biological chemistry 2004;279(44):46204-12.
2004: Posner Gary H; Crawford Kenneth R; Yang Hong Woon; Kahraman Mehmet; Jeon Heung Bae; Li Hongbin; Lee Jae Kyoo; Suh Byung Chul; Hatcher Mark A; Labonte Tanzina; Usera Aimee; Dolan Patrick M; Kensler Thomas W; Peleg Sara; Jones Glenville; Zhang Anqi; Korczak Bozena; Saha Uttam; Chuang Samuel S
Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):5-12.
2004: Dick Ryan A; Kensler Thomas W
The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase.
The Journal of biological chemistry 2004;279(17):17269-77.
2004: Kuang Shuang-Yuan; Jackson Peta E; Wang Jin-Bing; Lu Pei-Xing; Muñoz Alvaro; Qian Geng-Sun; Kensler Thomas W; Groopman John D
Specific mutations of hepatitis B virus in plasma predict liver cancer development.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3575-80.
2004: Dick Ryan A; Yu Xiang; Kensler Thomas W
NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1492-9.
2004: Wakabayashi Nobunao; Dinkova-Kostova Albena T; Holtzclaw W David; Kang Moon-Il; Kobayashi Akira; Yamamoto Masayuki; Kensler Thomas W; Talalay Paul
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2040-5.
2004: Kwak Mi-Kyoung; Ramos-Gomez Minerva; Wakabayashi Nobunao; Kensler Thomas W
Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymes.
Methods in enzymology 2004;382():414-23.
2003: Kwak Mi-Kyoung; Wakabayashi Nobunao; Greenlaw Jennifer L; Yamamoto Masayuki; Kensler Thomas W
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway.
Molecular and cellular biology 2003;23(23):8786-94.
2003: Roebuck B D; Curphey Thomas J; Li Yuan; Baumgartner Karen J; Bodreddigari Sridevi; Yan Jian; Gange Stephen J; Kensler Thomas W; Sutter Thomas R
Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.
Carcinogenesis 2003;24(12):1919-28.
2003: Petzer Jacobus P; Navamal Mettachit; Johnson Jesse K; Kwak Mi-Kyoung; Kensler Thomas W; Fishbein James C
Phase 2 enzyme induction by the major metabolite of oltipraz.
Chemical research in toxicology 2003;16(11):1463-9.
2003: Jackson Peta E; Kuang Shuang-Yuan; Wang Jin-Bing; Strickland Paul T; Muñoz Alvaro; Kensler Thomas W; Qian Geng-Sun; Groopman John D
Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patients.
Carcinogenesis 2003;24(10):1657-63.
2003: Egner Patricia A; Yu Xiang; Johnson Jesse K; Nathasingh Christopher K; Groopman John D; Kensler Thomas W; Roebuck Bill D
Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1.
Chemical research in toxicology 2003;16(9):1174-80.
2003: Guyton Kathryn Z; Kensler Thomas W; Posner Gary H
Vitamin D and vitamin D analogs as cancer chemopreventive agents.
Nutrition reviews 2003;61(7):227-38.
2003: Kwak Mi-Kyoung; Kensler Thomas W; Casero Robert A
Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein.
Biochemical and biophysical research communications 2003;305(3):662-70.
2003: Kensler Thomas W; Qian Geng-Sun; Chen Jian-Guo; Groopman John D
Translational strategies for cancer prevention in liver.
Nature reviews. Cancer 2003;3(5):321-9.
2003: Ramos-Gomez Minerva; Dolan Patrick M; Itoh Ken; Yamamoto Masayuki; Kensler Thomas W
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice.
Carcinogenesis 2003;24(3):461-7.
2003: Kwak Mi-Kyoung; Wakabayashi Nobunao; Itoh Ken; Motohashi Hozumi; Yamamoto Masayuki; Kensler Thomas W
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.
The Journal of biological chemistry 2003;278(10):8135-45.
2003: Egner Patricia A; Muñoz Alvaro; Kensler Thomas W
Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin.
Mutation research 2003;523-524():209-16.
2002: Sutter Thomas R; He Xiao-Rui; Dimitrov Peter; Xu Lijing; Narasimhan Giri; George E Olusegun; Sutter Carrie Hayes; Grubbs Clinton; Savory Richard; Stephan-Gueldner Markus; Kreder Dirk; Taylor Michael J; Lubet Ronald; Patterson Tricia A; Kensler Thomas W
Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents.
Molecular cancer therapeutics 2002;1(14):1283-92.
2002: Guyton Kathryn Z; Kensler Thomas W
Prevention of liver cancer.
Current oncology reports 2002;4(6):464-70.
2002: Dick Ryan A; Kensler Thomas W
Chemoprotective potential of phase 2 enzyme inducers.
Expert review of anticancer therapy 2002;2(5):581-92.
2002: Thimmulappa Rajesh K; Mai Kim H; Srisuma Sorachai; Kensler Thomas W; Yamamoto Masayuki; Biswal Shyam
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Cancer research 2002;62(18):5196-203.
2002: Kensler Thomas W; Egner Patricia A; Wang Jin-Bing; Zhu Yuan-Rong; Zhang Bao-Chu; Qian Geng-Sun; Kuang Shuang-Yuan; Gange Stephen J; Jacobson Lisa P; Muñoz Alvaro; Groopman John D
Strategies for chemoprevention of liver cancer.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2002;11 Suppl 2():S58-64.
2002: Posner Gary H; Woodard Benjamin T; Crawford Kenneth R; Peleg Sara; Brown Alex J; Dolan Patrick; Kensler Thomas W
2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology.
Bioorganic & medicinal chemistry 2002;10(7):2353-65.
2002: Fahey Jed W; Haristoy Xavier; Dolan Patrick M; Kensler Thomas W; Scholtus Isabelle; Stephenson Katherine K; Talalay Paul; Lozniewski Alain
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7610-5.
2002: Kwak Mi-Kyoung; Itoh Ken; Yamamoto Masayuki; Kensler Thomas W
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.
Molecular and cellular biology 2002;22(9):2883-92.
2002: Posner Gary H; Halford Bethany A; Peleg Sara; Dolan Patrick; Kensler Thomas W
Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing.
Journal of medicinal chemistry 2002;45(8):1723-30.
2002: Cho Hye-Youn; Jedlicka Anne E; Reddy Sekhar P M; Kensler Thomas W; Yamamoto Masayuki; Zhang Liu-Yi; Kleeberger Steven R
Role of NRF2 in protection against hyperoxic lung injury in mice.
American journal of respiratory cell and molecular biology 2002;26(2):175-82.
2002: Cho Hye-Youn; Jedlicka Anne E; Reddy Sekhar P M; Zhang Liu-Yi; Kensler Thomas W; Kleeberger Steven R
Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene.
American journal of respiratory cell and molecular biology 2002;26(1):42-51.
2002: Posner Gary H; Northrop John; Paik Ik-Hyeon; Borstnik Kristina; Dolan Patrick; Kensler Thomas W; Xie Suji; Shapiro Theresa A
New chemical and biological aspects of artemisinin-derived trioxane dimers.
Bioorganic & medicinal chemistry 2002;10(1):227-32.
2001: Nelson W G; De Marzo A M; Deweese T L; Lin X; Brooks J D; Putzi M J; Nelson C P; Groopman J D; Kensler T W
Preneoplastic prostate lesions: an opportunity for prostate cancer prevention.
Annals of the New York Academy of Sciences 2001;952():135-44.
2001: Egner P A; Wang J B; Zhu Y R; Zhang B C; Wu Y; Zhang Q N; Qian G S; Kuang S Y; Gange S J; Jacobson L P; Helzlsouer K J; Bailey G S; Groopman J D; Kensler T W
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14601-6.
2001: Dick R A; Kwak M K; Sutter T R; Kensler T W
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase.
The Journal of biological chemistry 2001;276(44):40803-10.
2001: Posner G H; Crawford K R; Peleg S; Welsh J E; Romu S; Gewirtz D A; Gupta M S; Dolan P; Kensler T W
A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin.
Bioorganic & medicinal chemistry 2001;9(9):2365-71.
2001: Parsons J K; Nelson C P; Gage W R; Nelson W G; Kensler T W; De Marzo A M
GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue.
The Prostate 2001;49(1):30-7.
2001: Kwak M K; Egner P A; Dolan P M; Ramos-Gomez M; Groopman J D; Itoh K; Yamamoto M; Kensler T W
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Mutation research 2001;480-481():305-15.
2001: Carey K A; Kensler T W; Fishbein J C
Kinetic constraints for the thiolysis of 4-methyl-5-(pyrazin-2-yl)-1,2-dithiole-3-thione (oltipraz) and related dithiole-3-thiones in aqueous solution.
Chemical research in toxicology 2001;14(8):939-45.
2001: Walton M; Egner P; Scholl P F; Walker J; Kensler T W; Groopman J D
Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats.
Chemical research in toxicology 2001;14(7):919-26.
2001: Camoirano A; Bagnasco M; Bennicelli C; Cartiglia C; Wang J B; Zhang B C; Zhu Y R; Qian G S; Egner P A; Jacobson L P; Kensler T W; De Flora S
Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(7):775-83.
2001: Ramos-Gomez M; Kwak M K; Dolan P M; Itoh K; Yamamoto M; Talalay P; Kensler T W
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3410-5.
2001: Kwak M K; Itoh K; Yamamoto M; Sutter T R; Kensler T W
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
Molecular medicine (Cambridge, Mass.) 2001;7(2):135-45.
2001: Wang J S; Huang T; Su J; Liang F; Wei Z; Liang Y; Luo H; Kuang S Y; Qian G S; Sun G; He X; Kensler T W; Groopman J D
Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(2):143-6.
2001: Jackson P E; Qian G S; Friesen M D; Zhu Y R; Lu P; Wang J B; Wu Y; Kensler T W; Vogelstein B; Groopman J D
Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry.
Cancer research 2001;61(1):33-5.
2001: Nelson C P; Kidd L C; Sauvageot J; Isaacs W B; De Marzo A M; Groopman J D; Nelson W G; Kensler T W
Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.
Cancer research 2001;61(1):103-9.
2001: Guyton K Z; Kensler T W; Posner G H
Cancer chemoprevention using natural vitamin D and synthetic analogs.
Annual review of pharmacology and toxicology 2001;41():421-42.
2001: Kensler T W; Davidson N E; Groopman J D; Muñoz A
Biomarkers and surrogacy: relevance to chemoprevention.
IARC scientific publications 2001;154():27-47.
2000: Posner G H; Crawford K; Siu-Caldera M L; Reddy G S; Sarabia S F; Feldman D; van Etten E; Mathieu C; Gennaro L; Vouros P; Peleg S; Dolan P M; Kensler T W
Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation.
Journal of medicinal chemistry 2000;43(19):3581-6.
2000: Egner P A; Stansbury K H; Snyder E P; Rogers M E; Hintz P A; Kensler T W
Identification and characterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial.
Chemical research in toxicology 2000;13(9):900-6.
2000: Otieno M A; Kensler T W
A role for protein kinase C-delta in the regulation of ornithine decarboxylase expression by oxidative stress.
Cancer research 2000;60(16):4391-6.
2000: Kensler T W; Dolan P M; Gange S J; Lee J K; Wang Q; Posner G H
Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis.
Carcinogenesis 2000;21(7):1341-5.
2000: Li Y; Su J; Qin L; Egner P A; Wang J; Groopman J D; Kensler T W; Roebuck B D
Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis).
Cancer letters 2000;154(1):79-83.
2000: Otieno M A; Kensler T W; Guyton K Z
Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo.
Free radical biology & medicine 2000;28(6):944-52.
2000: Kensler T W; Curphey T J; Maxiutenko Y; Roebuck B D
Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins.
Drug metabolism and drug interactions 2000;17(1-4):3-22.
1999: Kensler T W; Tsuda H; Wogan G N
United States-Japan workshop on New Rodent Models for the Analysis and Prevention of Carcinogenesis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(11):1033-7.
1999: Wang S S; O'Neill J P; Qian G S; Zhu Y R; Wang J B; Armenian H; Zarba A; Wang J S; Kensler T W; Cariello N F; Groopman J D; Swenberg J A
Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People's Republic of China.
Carcinogenesis 1999;20(11):2181-4.
1999: Posner G H; Ploypradith P; Parker M H; O'Dowd H; Woo S H; Northrop J; Krasavin M; Dolan P; Kensler T W; Xie S; Shapiro T A
Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.
Journal of medicinal chemistry 1999;42(21):4275-80.
1999: Posner G H; Wang Q; Han G; Lee J K; Crawford K; Zand S; Brem H; Peleg S; Dolan P; Kensler T W
Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
Journal of medicinal chemistry 1999;42(18):3425-35.
1999: Knight L P; Primiano T; Groopman J D; Kensler T W; Sutter T R
cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.
Carcinogenesis 1999;20(7):1215-23.
1999: Links J M; Kensler T W; Groopman J D
Biomarkers in environmental health research & practice.
Drug and chemical toxicology 1999;22(1):1-14.
1999: Wang J S; Shen X; He X; Zhu Y R; Zhang B C; Wang J B; Qian G S; Kuang S Y; Zarba A; Egner P A; Jacobson L P; Muñoz A; Helzlsouer K J; Groopman J D; Kensler T W
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
Journal of the National Cancer Institute 1999;91(4):347-54.
1999: Kensler T W; Groopman J D; Sutter T R; Curphey T J; Roebuck B D
Development of cancer chemopreventive agents: oltipraz as a paradigm.
Chemical research in toxicology 1999;12(2):113-26.
1999: Groopman J D; Kensler T W
The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight?
Carcinogenesis 1999;20(1):1-11.
1999: Primiano T; Kensler T W; Trush M A; Sutter T R
Induction of leukotriene B4 metabolism by cancer chemopreventive agents.
Advances in experimental medicine and biology 1999;469():599-605.
1998: Maxuitenko Y Y; Libby A H; Joyner H H; Curphey T J; MacMillan D L; Kensler T W; Roebuck B D
Identification of dithiolethiones with better chemopreventive properties than oltipraz.
Carcinogenesis 1998;19(9):1609-15.
1998: Posner G H; Lee J K; Wang Q; Peleg S; Burke M; Brem H; Dolan P; Kensler T W
Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation.
Journal of medicinal chemistry 1998;41(16):3008-14.
1998: Kensler T W; Groopman J D; Roebuck B D
Use of aflatoxin adducts as intermediate endpoints to assess the efficacy of chemopreventive interventions in animals and man.
Mutation research 1998;402(1-2):165-72.
1998: Primiano T; Li Y; Kensler T W; Trush M A; Sutter T R
Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention.
Carcinogenesis 1998;19(6):999-1005.
1998: Berchtold C M; Tamez P; Kensler T W; Casero R A
Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels.
Journal of cellular physiology 1998;174(3):380-6.
1998: Kensler T W; He X; Otieno M; Egner P A; Jacobson L P; Chen B; Wang J S; Zhu Y R; Zhang B C; Wang J B; Wu Y; Zhang Q N; Qian G S; Kuang S Y; Fang X; Li Y F; Yu L Y; Prochaska H J; Davidson N E; Gordon G B; Gorman M B; Zarba A; Enger C; Muñoz A; Helzlsouer K J
Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(2):127-34.
1997: Primiano T; Sutter T R; Kensler T W
Redox regulation of genes that protect against carcinogens.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997;118(3):487-97.
1997: Guyton K Z; Kensler T W
Prevention of liver cancer.
Current opinion in oncology 1997;9(5):492-6.
1997: Kensler T W; Gange S J; Egner P A; Dolan P M; Muñoz A; Groopman J D; Rogers A E; Roebuck B D
Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(8):603-10.
1997: Posner G H; Ploypradith P; Hapangama W; Wang D; Cumming J N; Dolan P; Kensler T W; Klinedinst D; Shapiro T A; Zheng Q Y; Murray C K; Pilkington L G; Jayasinghe L R; Bray J F; Daughenbaugh R
Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
Bioorganic & medicinal chemistry 1997;5(7):1257-65.
1997: Roebuck B D; Rogers A E; Kensler T W
Correspondence re: C.V. Rao, et al., Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced lymphoma formation by oltipraz. Cancer Res., 56: 3395-3398, 1996.
Cancer research 1997;57(13):2806-7.
1997: Kensler T W
Chemoprevention by inducers of carcinogen detoxication enzymes.
Environmental health perspectives 1997;105 Suppl 4():965-70.
1997: Jacobson L P; Zhang B C; Zhu Y R; Wang J B; Wu Y; Zhang Q N; Yu L Y; Qian G S; Kuang S Y; Li Y F; Fang X; Zarba A; Chen B; Enger C; Davidson N E; Gorman M B; Gordon G B; Prochaska H J; Egner P A; Groopman J D; Muñoz A; Helzlsouer K J; Kensler T W
Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(4):257-65.
1997: Zhang B C; Zhu Y R; Wang J B; Wu Y; Zhang Q N; Qian G S; Kuang S Y; Li Y F; Fang X; Yu L Y; De Flora S; Jacobson L P; Zarba A; Egner P A; He X; Wang J S; Chen B; Enger C L; Davidson N E; Gordon G B; Gorman M B; Prochaska H J; Groopman J D; Muñoz A; Kensler T W
Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.
Journal of cellular biochemistry. Supplement 1997;28-29():166-73.
1997: Primiano T; Sutter T R; Kensler T W
Antioxidant-inducible genes.
Advances in pharmacology (San Diego, Calif.) 1997;38():293-328.
1996: Primiano T; Gastel J A; Kensler T W; Sutter T R
Isolation of cDNAs representing dithiolethione-responsive genes.
Carcinogenesis 1996;17(11):2297-303.
1996: Primiano T; Kensler T W; Kuppusamy P; Zweier J L; Sutter T R
Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones.
Carcinogenesis 1996;17(11):2291-6.
1996: Maxuitenko Y Y; Curphey T J; Kensler T W; Roebuck B D
Protection against aflatoxin B1-induced hepatic toxicity as short-term screen of cancer chemopreventive dithiolethiones.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;32(2):250-9.
1996: Guyton K Z; Gorospe M; Kensler T W; Holbrook N J
Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion.
Cancer research 1996;56(15):3480-5.
1996: Scholl P; Musser S M; Kensler T W; Groopman J D
Inhibition of aflatoxin Ml excretion in rat urine during dietary intervention with oltipraz.
Carcinogenesis 1996;17(6):1385-8.
1996: Wang J S; Qian G S; Zarba A; He X; Zhu Y R; Zhang B C; Jacobson L; Gange S J; Muñoz A; Kensler T W
Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People's Republic of China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996;5(4):253-61.
1996: King J K; Egner P A; Kensler T W
Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide.
Carcinogenesis 1996;17(2):317-20.
1996: De Flora S; Camoirano A; Bagnasco M; Bennicelli C; van Zandwijk N; Wigbout G; Qian G S; Zhu Y R; Kensler T W
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials.
Journal of cellular biochemistry. Supplement 1996;25():92-8.
1996: Kensler T W; Groopman J D
Carcinogen-DNA and protein adducts: biomarkers for cohort selection and modifiable endpoints in chemoprevention trials.
Journal of cellular biochemistry. Supplement 1996;25():85-91.
1996: Kensler T W; Groopman J D; Wogan G N
Use of carcinogen-DNA and carcinogen-protein adduct biomarkers for cohort selection and as modifiable end points in chemoprevention trials.
IARC scientific publications 1996;(139):237-48.
1995: Groopman J D; Kensler T W; Links J M
Molecular epidemiology and human risk monitoring.
Toxicology letters 1995;82-83():763-9.
1995: Primiano T; Egner P A; Sutter T R; Kelloff G J; Roebuck B D; Kensler T W
Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.
Cancer research 1995;55(19):4319-24.
1995: Posner G H; Li Z; White M C; Vinader V; Takeuchi K; Guggino S E; Dolan P; Kensler T W
1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing.
Journal of medicinal chemistry 1995;38(22):4529-37.
1995: Egner P A; Gange S J; Dolan P M; Groopman J D; Muñoz A; Kensler T W
Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz.
Carcinogenesis 1995;16(8):1769-73.
1995: Kensler T W; Helzlsouer K J
Oltipraz: clinical opportunities for cancer chemoprevention. p.
Journal of cellular biochemistry. Supplement 1995;22():101-7.
1995: Kensler T; Guyton K; Egner P; McCarthy T; Lesko S; Akman S
Role of reactive intermediates in tumor promotion and progression.
Progress in clinical and biological research 1995;391():103-16.
1995: Links J M; Kensler T W; Groopman J D
Biomarkers and mechanistic approaches in environmental epidemiology.
Annual review of public health 1995;16():83-103.
1995: Scholl P; Musser S M; Kensler T W; Groopman J D
Molecular biomarkers for aflatoxins and their application to human liver cancer.
Pharmacogenetics 1995;5 Spec No():S171-6.
1994: Guyton K Z; Dolan P M; Kensler T W
Quinone methide mediates in vitro induction of ornithine decarboxylase by the tumor promoter butylated hydroxytoluene hydroperoxide.
Carcinogenesis 1994;15(5):817-21.
1994: Zhang Y; Kensler T W; Cho C G; Posner G H; Talalay P
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3147-50.
1994: Groopman J D; Wogan G N; Roebuck B D; Kensler T W
Molecular biomarkers for aflatoxins and their application to human cancer prevention.
Cancer research 1994;54(7 Suppl):1907s-1911s.
1994: Egner P A; Kensler T W; Prestera T; Talalay P; Libby A H; Joyner H H; Curphey T J
Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones.
Carcinogenesis 1994;15(2):177-81.
1994: Trush M A; Egner P A; Kensler T W
Myeloperoxidase as a biomarker of skin irritation and inflammation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(2):143-7.
1994: Groopman J D; Roebuck B D; Kensler T W
Carcinogen-DNA and protein adducts as intermediate biomarkers for human chemoprotection trials.
Advances in experimental medicine and biology 1994;354():149-60.
1993: Maxuitenko Y Y; MacMillan D L; Kensler T W; Roebuck B D
Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis.
Carcinogenesis 1993;14(11):2423-5.
1993: Styczynski P B; Blackmon R C; Groopman J D; Kensler T W
The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by human and rabbit liver microsomes.
Chemical research in toxicology 1993;6(6):846-51.
1993: Groopman J D; Kensler T W
Molecular biomarkers for human chemical carcinogen exposures.
Chemical research in toxicology 1993;6(6):764-70.
1993: Akman S A; Kensler T W; Doroshow J H; Dizdaroglu M
Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide.
Carcinogenesis 1993;14(9):1971-4.
1993: Guyton K Z; Thompson J A; Kensler T W
Role of quinone methide in the in vitro toxicity of the skin tumor promoter butylated hydroxytoluene hydroperoxide.
Chemical research in toxicology 1993;6(5):731-8.
1993: Helzlsouer K J; Kensler T W
Cancer chemoprotection by oltipraz: experimental and clinical considerations.
Preventive medicine 1993;22(5):783-95.
1993: Hruban R H; van Mansfeld A D; Offerhaus G J; van Weering D H; Allison D C; Goodman S N; Kensler T W; Bose K K; Cameron J L; Bos J L
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
The American journal of pathology 1993;143(2):545-54.
1993: Bolton M G; Muñoz A; Jacobson L P; Groopman J D; Maxuitenko Y Y; Roebuck B D; Kensler T W
Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis.
Cancer research 1993;53(15):3499-504.
1993: Westra W H; Slebos R J; Offerhaus G J; Goodman S N; Evers S G; Kensler T W; Askin F B; Rodenhuis S; Hruban R H
K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.
Cancer 1993;72(2):432-8.
1993: Guyton K Z; Kensler T W
Oxidative mechanisms in carcinogenesis.
British medical bulletin 1993;49(3):523-44.
1993: Meyer D J; Harris J M; Gilmore K S; Coles B; Kensler T W; Ketterer B
Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones.
Carcinogenesis 1993;14(4):567-72.
1993: Groopman J D; Wild C P; Hasler J; Junshi C; Wogan G N; Kensler T W
Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans.
Environmental health perspectives 1993;99():107-13.
1993: Morel F; Fardel O; Meyer D J; Langouet S; Gilmore K S; Meunier B; Tu C P; Kensler T W; Ketterer B; Guillouzo A
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
Cancer research 1993;53(2):231-4.
1993: Meyer D J; Coles B; Harris J; Gilmore K S; Raney K; Harris T M; Guengerich F P; Kensler T W; Ketterer B
Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties.
Basic life sciences 1993;61():171-9.
1993: Kensler T W; Davidson N E; Groopman J D; Roebuck B D; Prochaska H J; Talalay P
Chemoprotection by inducers of electrophile detoxication enzymes.
Basic life sciences 1993;61():127-36.
1992: Akman S A; Doroshow J H; Kensler T W
Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189.
Carcinogenesis 1992;13(10):1783-7.
1992: Posner G H; Nelson T D; Guyton K Z; Kensler T W
New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs.
Journal of medicinal chemistry 1992;35(17):3280-7.
1992: Groopman J D; DeMatos P; Egner P A; Love-Hunt A; Kensler T W
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats.
Carcinogenesis 1992;13(1):101-6.
1992: Kensler T W; Groopman J D; Eaton D L; Curphey T J; Roebuck B D
Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione.
Carcinogenesis 1992;13(1):95-100.
1992: Groopman J D; Roebuck B D; Kensler T W
Molecular dosimetry of aflatoxin DNA adducts in humans and experimental rat models.
Progress in clinical and biological research 1992;374():139-55.
1992: Kensler T; Styczynski P; Groopman J; Helzlsouer K; Curphey T; Maxuitenko Y; Roebuck B D
Mechanisms of chemoprotection by oltipraz.
Journal of cellular biochemistry. Supplement 1992;16I():167-72.
1991: Roebuck B D; Liu Y L; Rogers A E; Groopman J D; Kensler T W
Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.
Cancer research 1991;51(20):5501-6.
1991: Swauger J E; Dolan P M; Zweier J L; Kuppusamy P; Kensler T W
Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide.
Chemical research in toxicology 1991;4(2):223-8.
1991: Guyton K Z; Bhan P; Kuppusamy P; Zweier J L; Trush M A; Kensler T W
Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):946-50.
1991: Trush M A; Kensler T W
An overview of the relationship between oxidative stress and chemical carcinogenesis.
Free radical biology & medicine 1991;10(3-4):201-9.
1990: Davidson N E; Egner P A; Kensler T W
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.
Cancer research 1990;50(8):2251-5.
1990: Seed J L; Kensler T W; Elia M; Trush M A
Induction of sister-chromatid exchanges by polycyclic aromatic hydrocarbons following metabolic activation with phorbol ester-stimulated human polymorphonuclear leukocytes.
Research communications in chemical pathology and pharmacology 1990;67(3):349-60.
1990: Swauger J E; Dolan P M; Kensler T W
Role of free radicals in tumor promotion and progression by benzoyl peroxide.
Progress in clinical and biological research 1990;340D():143-52.
1989: Taffe B G; Zweier J L; Pannell L K; Kensler T W
Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin.
Carcinogenesis 1989;10(7):1261-8.
1989: Kensler T W; Egner P A; Taffe B G; Trush M A
Role of free radicals in tumor promotion and progression.
Progress in clinical and biological research 1989;298():233-48.
1988: Taffe B G; Kensler T W
Tumor promotion by a hydroperoxide metabolite of butylated hydroxytoluene, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone, in mouse skin.
Research communications in chemical pathology and pharmacology 1988;61(3):291-303.
1988: Liu Y L; Roebuck B D; Yager J D; Groopman J D; Kensler T W
Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat.
Toxicology and applied pharmacology 1988;93(3):442-51.
1988: Groopman J D; Cain L G; Kensler T W
Aflatoxin exposure in human populations: measurements and relationship to cancer.
Critical reviews in toxicology 1988;19(2):113-45.
1987: Kensler T W; Egner P A; Moore K G; Taffe B G; Twerdok L E; Trush M A
Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin.
Toxicology and applied pharmacology 1987;90(2):337-46.
1987: Taffe B G; Takahashi N; Kensler T W; Mason R P
Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes. Formation of alkyl and alkoxyl radicals from tert-butyl hydroperoxide and cumene hydroperoxide.
The Journal of biological chemistry 1987;262(25):12143-9.
1987: Kensler T W; Egner P A; Dolan P M; Groopman J D; Roebuck B D
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
Cancer research 1987;47(16):4271-7.
1987: Groopman J D; Kensler T W
The use of monoclonal antibody affinity columns for assessing DNA damage and repair following exposure to aflatoxin B1.
Pharmacology & therapeutics 1987;34(2):321-34.
1987: Groopman J D; Roebuck B D; Kensler T W
Application of monoclonal antibodies and dietary antioxidant-based animal models to define human exposure to aflatoxin B1.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1987;31():52-62.
1986: Kensler T W; Egner P A; Davidson N E; Roebuck B D; Pikul A; Groopman J D
Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.
Cancer research 1986;46(8):3924-31.
1986: Trush M A; Kensler T W; Seed J L
Activation of xenobiotics by human polymorphonuclear leukocytes via reactive oxygen-dependent reactions.
Advances in experimental medicine and biology 1986;197():311-21.
1985: Egner P A; Kensler T W
Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin.
Carcinogenesis 1985;6(8):1167-72.
1985: Trush M A; Seed J L; Kensler T W
Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(15):5194-8.
1985: Kozumbo W J; Trush M A; Kensler T W
Are free radicals involved in tumor promotion?
Chemico-biological interactions 1985;54(2):199-207.
1985: Kensler T W; Egner P A; Trush M A; Bueding E; Groopman J D
Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione.
Carcinogenesis 1985;6(5):759-63.
1985: Trush M A; Seed J L; Kensler T W
Reactive oxygen dependent activation of polycyclic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes.
Carcinogenesis; a comprehensive survey 1985;8():293-303.
1984: Roebuck B D; MacMillan D L; Bush D M; Kensler T W
Modulation of azaserine-induced pancreatic foci by phenolic antioxidants in rats.
Journal of the National Cancer Institute 1984;72(6):1405-10.
1984: Kensler T W; Trush M A
Role of oxygen radicals in tumor promotion.
Environmental mutagenesis 1984;6(4):593-616.
1983: Kensler T W; Trush M A
Inhibition of oxygen radical metabolism in phorbol ester-activated polymorphonuclear leukocytes by an antitumor promoting copper complex with superoxide dismutase-mimetic activity.
Biochemical pharmacology 1983;32(22):3485-7.
1983: Kensler T W; Bush D M; Kozumbo W J
Inhibition of tumor promotion by a biomimetic superoxide dismutase.
Science (New York, N.Y.) 1983;221(4605):75-7.
1983: Kozumbo W J; Seed J L; Kensler T W
Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 1983;43(6):2555-9.
1982: Kensler T W; Jayaram H N; Cooney D A
Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.
Advances in enzyme regulation 1982;20():57-73.
1981: Kensler T W; Cooney D A; Jayaram H N; Schaeffer C; Choie D D
A facile tritium release assay for mammalian L-dihydroorotate dehydrogenase.
Analytical biochemistry 1981;117(2):315-9.
1981: Ardalan B; Glazer R I; Kensler T W; Jayaram H N; Van Pham T; Macdonald J S; Cooney D A
Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-L-aspartate on cell growth and ribonucleic acid synthesis in human mammary carcinoma.
Biochemical pharmacology 1981;30(15):2045-9.
1981: Jayaram H N; Kensler T W; Ardalan B
Radiometric enzyme-inhibition technique for measuring acivicin in plasma.
Cancer treatment reports 1981;65(5-6):491-4.
1981: Kensler T W; Reck L J; Cooney D A
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
Cancer research 1981;41(3):905-9.
1981: Kensler T W; Mutter G; Hankerson J G; Reck L J; Harley C; Han N; Ardalan B; Cysyk R L; Johnson R K; Jayaram H N; Cooney D A
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
Cancer research 1981;41(3):894-904.
1981: Kensler T W; Han N; Cooney D A
A straightforward method for the simultaneous preparation of radiolabeled L-dihydroörotic and N-carbamyl-L-aspartic acids.
Analytical biochemistry 1981;111(1):49-53.
1981: Ardalan B; Kensler T W; Jayaram H N; Morrison W; Choie D D; Chadwick M; Liss R; Cooney D A
Long-term association of N-(phosphonacetyl)-L-aspartate with bone.
Cancer research 1981;41(1):150-6.
1981: Kensler T W; Trush M A
Inhibiton of phorbol ester-stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxyretinoic acid.
Cancer research 1981;41(1):216-22.
1981: Kensler T W; Cooney D A
Chemotherapeutic inhibitors of the enzymes of the de novo pyrimidine pathway.
Advances in pharmacology and chemotherapy 1981;18():273-352.
1980: Kensler T W; Erlichman C; Jayaram H N; Tyagi A K; Ardalan B; Cooney D A
Peripheral leukocytes as indicators of the enzymatic effects of N-(phosphonacetyl)-L-aspartic acid (PALA) on human L-aspartate transcarbamoylase (ATCase) activity.
Cancer treatment reports 1980;64(8-9):967-73.
1980: Kensler T W; Jayaram H N; Cooney D A
A facile enzymatic technique for the estimation of nanomolar concentrations of N-phosphonacetyl-L-aspartic acid in plasma.
Journal of biochemical and biophysical methods 1980;2(1):29-35.
1979: Kensler T W; Wertz P W; Mueller G C
Inhibition of phorbol ester-accelerated amino acid transport in bovine lymphocytes.
Biochimica et biophysica acta 1979;585(1):43-52.
1979: Wertz P W; Kensler T W; Mueller G C; Verma A K; Boutwell R K
5,6-epoxyretinoic acid opposes the effects of 12-O-tetradecanoylphorbol-13-acetate in bovine lymphocytes.
Nature 1979;277(5693):227-9.
1978: Kensler T W; Verma A K; Boutwell R K; Mueller G C
Effects of retinoic acid and juvenile hormone on the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 1978;38(9):2896-9.
1978: Wertz P W; Kensler T W; Mueller G C
Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-beta-ionone.
Biochemical and biophysical research communications 1978;83(1):138-43.
1978: Kensler T W; Mueller G C
Retinoic acid inhibition of the comitogenic action of mezerein and phorbol esters in bovine lymphocytes.
Cancer research 1978;38(3):771-5.
1978: Kensler T W; Mueller G C
Effects of hexachlorocyclohexane isomers on the mitogenic response of bovine lymphocytes.
Biochemical pharmacology 1978;27(5):667-71.
1978: Kensler T W; Mueller G C
Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones.
Life sciences 1978;22(6):505-9.
1976: Kensler T W; Busby W F; Davidson N E; Wogan G N
Effect of hepatocarcinogens on the binding of glucocorticoid-receptor complex in rat liver nuclei.
Cancer research 1976;36(12):4647-51.
1976: Kensler T W; Busby W F; Davidson N E; Wogan G N
Aflatoxin inhibition of glucocorticoid finding capacity of rat liver nuclei.
Biochimica et biophysica acta 1976;437(1):200-10.

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