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Kevin Keough

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TOP 3
Olga Cañadas; Kevin M W Keough; Cristina Casals
Bacterial lipopolysaccharide promotes destabilization of lung surfactant-like films.
Olga Cañadas; Ignacio García-Verdugo; Kevin M W Keough; Cristina Casals
SP-A permeabilizes lipopolysaccharide membranes by forming protein aggregates that extract lipids from the membrane.
Ignacio García-Verdugo; Olga Cañadas; Svetla G Taneva; Kevin M W Keough; Cristina Casals
Surfactant protein A forms extensive lattice-like structures on 1,2-dipalmitoylphosphatidylcholine/rough-lipopolysaccharide-mixed monolayers.

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All Publications

2011: Olga Cañadas; Kevin M W Keough; Cristina Casals
Bacterial lipopolysaccharide promotes destabilization of lung surfactant-like films.
Biophysical journal 2011;100(1):108-16.
2008: Olga Cañadas; Ignacio García-Verdugo; Kevin M W Keough; Cristina Casals
SP-A permeabilizes lipopolysaccharide membranes by forming protein aggregates that extract lipids from the membrane.
Biophysical journal 2008;95(7):3287-94.
2007: Ignacio García-Verdugo; Olga Cañadas; Svetla G Taneva; Kevin M W Keough; Cristina Casals
Surfactant protein A forms extensive lattice-like structures on 1,2-dipalmitoylphosphatidylcholine/rough-lipopolysaccharide-mixed monolayers.
Biophysical journal 2007;93(10):3529-40.
2007: Muzaddid Sarker; Alan J Waring; Frans J Walther; Kevin M W Keough; Valerie Booth
Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles.
Biochemistry 2007;46(39):11047-56.
2007: Guirong Wang; Svetla G Taneva; Kevin M W Keough; Joanna Floros
Differential effects of human SP-A1 and SP-A2 variants on phospholipid monolayers containing surfactant protein B.
Biochimica et biophysica acta 2007;1768(9):2060-9.
2007: Michael R Morrow; Sara Temple; June Stewart; Kevin M W Keough
Comparison of DPPC and DPPG environments in pulmonary surfactant models.
Biophysical journal 2007;93(1):164-75.
2006: I D Skanes; June Stewart; Kevin M W Keough; Michael R Morrow
Effect of chain unsaturation on bilayer response to pressure.
Physical review. E, Statistical, nonlinear, and soft matter physics 2006;74(5 Pt 1):051913.
2006: Marcus Larsson; Tommy Nylander; Kevin M W Keough; Kaushik Nag
An X-ray diffraction study of alterations in bovine lung surfactant bilayer structures induced by albumin.
Chemistry and physics of lipids 2006;144(2):137-45.
2006: Kaushik Nag; Kevin M W Keough; Michael R Morrow
Probing perturbation of bovine lung surfactant extracts by albumin using DSC and 2H-NMR.
Biophysical journal 2006;90(10):3632-42.
2005: Inés Plasencia; Kevin M W Keough; Jesus Perez-Gil
Interaction of the N-terminal segment of pulmonary surfactant protein SP-C with interfacial phospholipid films.
Biochimica et biophysica acta 2005;1713(2):118-28.
2004: Valerie Booth; Alan J Waring; Frans J Walther; Kevin M W Keough
NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol.
Biochemistry 2004;43(48):15187-94.
2004: Michael R Morrow; June Stewart; Svetla G Taneva; Awel Dico; Kevin M W Keough
Perturbation of DPPC bilayers by high concentrations of pulmonary surfactant protein SP-B.
European biophysics journal : EBJ 2004;33(4):285-90.
2004: Inés Plasencia; Luis Rivas; Kevin M W Keough; Derek Marsh; Jesús Pérez-Gil
The N-terminal segment of pulmonary surfactant lipopeptide SP-C has intrinsic propensity to interact with and perturb phospholipid bilayers.
The Biochemical journal 2004;377(Pt 1):183-93.
2003: Kevin M W Keough
How thin can glass be? New ideas, new approaches.
Biophysical journal 2003;85(5):2785-6.
2003: Michael R Morrow; Nidal Abu-Libdeh; June Stewart; Kevin M W Keough
Interaction of pulmonary surfactant protein SP-A with DPPC/egg-PG bilayers.
Biophysical journal 2003;85(4):2397-405.
2003: Carol R Flach; Peng Cai; Darline Dieudonné; Joseph W Brauner; Kevin M W Keough; June Stewart; Richard Mendelsohn
Location of structural transitions in an isotopically labeled lung surfactant SP-B peptide by IRRAS.
Biophysical journal 2003;85(1):340-9.
2001: X Bi; Svetla G Taneva; Kevin M W Keough; Richard Mendelsohn; Carol R Flach
Thermal stability and DPPC/Ca2+ interactions of pulmonary surfactant SP-A from bulk-phase and monolayer IR spectroscopy.
Biochemistry 2001;40(45):13659-69.
2001: Inés Plasencia; L Rivas; Cristina Casals; Kevin M W Keough; Jesús Pérez-Gil
Intrinsic structural differences in the N-terminal segment of pulmonary surfactant protein SP-C from different species.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;129(1):129-39.
2000: LA Worthman; Kaushik Nag; N Rich; ML Ruano; Cristina Casals; Jesús Pérez-Gil; Kevin M W Keough
Pulmonary surfactant protein A interacts with gel-like regions in monolayers of pulmonary surfactant lipid extract.
Biophysical journal 2000;79(5):2657-66.
2000: Svetla G Taneva; Kevin M W Keough
Differential effects of surfactant protein A on regional organization of phospholipid monolayers containing surfactant protein B or C.
Biophysical journal 2000;79(4):2010-23.
2000: Svetla G Taneva; Kevin M W Keough
Adsorption of pulmonary surfactant protein SP-A to monolayers of phospholipids containing hydrophobic surfactant protein SP-B or SP-C: potential differential role for tertiary interaction of lipids, hydrophobic proteins, and SP-A.
Biochemistry 2000;39(20):6083-93.
2000: Antonio Cruz; LA Worthman; Alicia G Serrano; Cristina Casals; Kevin M W Keough; Jesús Pérez-Gil
Microstructure and dynamic surface properties of surfactant protein SP-B/dipalmitoylphosphatidylcholine interfacial films spread from lipid-protein bilayers.
European biophysics journal : EBJ 2000;29(3):204-13.
1999: ML Ruano; Kaushik Nag; Cristina Casals; Jesús Pérez-Gil; Kevin M W Keough
Interactions of pulmonary surfactant protein A with phospholipid monolayers change with pH.
Biophysical journal 1999;77(3):1469-76.
1999: Carol R Flach; A Gericke; Kevin M W Keough; Richard Mendelsohn
Palmitoylation of lung surfactant protein SP-C alters surface thermodynamics, but not protein secondary structure or orientation in 1,2-dipalmitoylphosphatidylcholine langmuir films.
Biochimica et biophysica acta 1999;1416(1-2):11-20.
1998: Jesús Pérez-Gil; Kevin M W Keough
Interfacial properties of surfactant proteins.
Biochimica et biophysica acta 1998;1408(2-3):203-17.
1998: Kaushik Nag; Jesus Perez-Gil; ML Ruano; LA Worthman; June Stewart; Cristina Casals; Kevin M W Keough
Phase transitions in films of lung surfactant at the air-water interface.
Biophysical journal 1998;74(6):2983-95.
1998: Svetla G Taneva; June Stewart; L Taylor; Kevin M W Keough
Method of purification affects some interfacial properties of pulmonary surfactant proteins B and C and their mixtures with dipalmitoylphosphatidylcholine.
Biochimica et biophysica acta 1998;1370(1):138-50.
1998: ML Ruano; Kaushik Nag; LA Worthman; Cristina Casals; Jesús Pérez-Gil; Kevin M W Keough
Differential partitioning of pulmonary surfactant protein SP-A into regions of monolayers of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol.
Biophysical journal 1998;74(3):1101-9.
1997: Awel Dico; Svetla G Taneva; Michael R Morrow; Kevin M W Keough
Effect of calcium on phospholipid interaction with pulmonary surfactant protein C.
Biophysical journal 1997;73(5):2595-602.
1997: A Cruz; Cristina Casals; Kevin M W Keough; Jesús Pérez-Gil
Different modes of interaction of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers.
The Biochemical journal 1997;327 ( Pt 1)():133-8.
1997: Michael R Morrow; Svetla G Taneva; Awel Dico; J Hancock; Kevin M W Keough
What NMR can tell us about where lung surfactant proteins live.
Biochemical Society transactions 1997;25(3):1103-7.
1997: Svetla G Taneva; D R Voelker; Kevin M W Keough
Adsorption of pulmonary surfactant protein D to phospholipid monolayers at the air-water interface.
Biochemistry 1997;36(26):8173-9.
1997: Kaushik Nag; Svetla G Taneva; Jesus Perez-Gil; A Cruz; Kevin M W Keough
Combinations of fluorescently labeled pulmonary surfactant proteins SP-B and SP-C in phospholipid films.
Biophysical journal 1997;72(6):2638-50.
1997: LA Worthman; Kaushik Nag; Philip J Davis; Kevin M W Keough
Cholesterol in condensed and fluid phosphatidylcholine monolayers studied by epifluorescence microscopy.
Biophysical journal 1997;72(6):2569-80.
1997: Awel Dico; J Hancock; Michael R Morrow; June Stewart; S Harris; Kevin M W Keough
Pulmonary surfactant protein SP-B interacts similarly with dipalmitoylphosphatidylglycerol and dipalmitoylphosphatidylcholine in phosphatidylcholine/phosphatidylglycerol mixtures.
Biochemistry 1997;36(14):4172-7.
1997: Svetla G Taneva; Kevin M W Keough
Cholesterol modifies the properties of surface films of dipalmitoylphosphatidylcholine plus pulmonary surfactant-associated protein B or C spread or adsorbed at the air-water interface.
Biochemistry 1997;36(4):912-22.
1996: Michael R Morrow; P J Davis; C S Jackman; Kevin M W Keough
Thermal history alters cholesterol effect on transition of 1-palmitoyl-2-linoleoyl phosphatidylcholine.
Biophysical journal 1996;71(6):3207-14.
1996: Kaushik Nag; Jesus Perez-Gil; A Cruz; N H Rich; Kevin M W Keough
Spontaneous formation of interfacial lipid-protein monolayers during adsorption from vesicles.
Biophysical journal 1996;71(3):1356-63.
1996: Kaushik Nag; Jesus Perez-Gil; A Cruz; Kevin M W Keough
Fluorescently labeled pulmonary surfactant protein C in spread phospholipid monolayers.
Biophysical journal 1996;71(1):246-56.
1995: B Pastrana-Rios; Svetla G Taneva; Kevin M W Keough; A J Mautone; Richard Mendelsohn
External reflection absorption infrared spectroscopy study of lung surfactant proteins SP-B and SP-C in phospholipid monolayers at the air/water interface.
Biophysical journal 1995;69(6):2531-40.
1995: T M McEachren; Kevin M W Keough
Phosphocholine reverses inhibition of pulmonary surfactant adsorption caused by C-reactive protein.
The American journal of physiology 1995;269(4 Pt 1):L492-7.
1995: Svetla G Taneva; T McEachren; June Stewart; Kevin M W Keough
Pulmonary surfactant protein SP-A with phospholipids in spread monolayers at the air-water interface.
Biochemistry 1995;34(32):10279-89.
1995: Svetla G Taneva; Kevin M W Keough
Calcium ions and interactions of pulmonary surfactant proteins SP-B and SP-C with phospholipids in spread monolayers at the air/water interface.
Biochimica et biophysica acta 1995;1236(1):185-95.
1994: Svetla G Taneva; Kevin M W Keough
Dynamic surface properties of pulmonary surfactant proteins SP-B and SP-C and their mixtures with dipalmitoylphosphatidylcholine.
Biochemistry 1994;33(49):14660-70.
1994: Svetla G Taneva; Kevin M W Keough
Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: III. Proteins SP-B plus SP-C with phospholipids in spread monolayers.
Biophysical journal 1994;66(4):1158-66.
1994: Svetla G Taneva; Kevin M W Keough
Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: II. Monolayers of pulmonary surfactant protein SP-C and phospholipids.
Biophysical journal 1994;66(4):1149-57.
1994: Svetla G Taneva; Kevin M W Keough
Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: I. Monolayers of pulmonary surfactant protein SP-B and phospholipids.
Biophysical journal 1994;66(4):1137-48.
1993: J Hernandez-Borrell; Kevin M W Keough
Heteroacid phosphatidylcholines with different amounts of unsaturation respond differently to cholesterol.
Biochimica et biophysica acta 1993;1153(2):277-82.
1993: Michael R Morrow; Svetla G Taneva; G A Simatos; L A Allwood; Kevin M W Keough
2H NMR studies of the effect of pulmonary surfactant SP-C on the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine headgroup: a model for transbilayer peptides in surfactant and biological membranes.
Biochemistry 1993;32(42):11338-44.
1993: Kaushik Nag; Kevin M W Keough
Epifluorescence microscopic studies of monolayers containing mixtures of dioleoyl- and dipalmitoylphosphatidylcholines.
Biophysical journal 1993;65(3):1019-26.
1993: P L Matthews; E Bartlett; V S Ananthanarayanan; Kevin M W Keough
Reconstitution of rabbit sarcoplasmic reticulum calcium ATPase in a series of phosphatidylcholines containing a saturated and an unsaturated chain: suggestion of an optimal lipid environment.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1993;71(7-8):381-9.
1993: Michael R Morrow; Jesús Pérez-Gil; G Simatos; C Boland; June Stewart; D Absolom; V Sarin; Kevin M W Keough
Pulmonary surfactant-associated protein SP-B has little effect on acyl chains in dipalmitoylphosphatidylcholine dispersions.
Biochemistry 1993;32(16):4397-402.
1992: Jesús Pérez-Gil; Kaushik Nag; Svetla G Taneva; Kevin M W Keough
Pulmonary surfactant protein SP-C causes packing rearrangements of dipalmitoylphosphatidylcholine in spread monolayers.
Biophysical journal 1992;63(1):197-204.
1992: N Vrbjar; K T Kean; A Szabo; L Senak; Richard Mendelsohn; Kevin M W Keough
Sarcoplasmic reticulum from rabbit and winter flounder: temperature-dependence of protein conformation and lipid motion.
Biochimica et biophysica acta 1992;1107(1):1-11.
1992: Jesús Pérez-Gil; J Tucker; G Simatos; Kevin M W Keough
Interfacial adsorption of simple lipid mixtures combined with hydrophobic surfactant protein from pig lung.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(5):332-8.
1992: G R Herzberg; Garry Chernenko; J A Barrowman; K T Kean; Kevin M W Keough
Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil.
Biochimica et biophysica acta 1992;1124(2):190-4.
1991: Michael R Morrow; G A Simatos; R Srinivasan; N Grandal; L Taylor; Kevin M W Keough
The effect of changes in gramicidin conformation on bilayer lipid properties.
Biochimica et biophysica acta 1991;1070(1):209-14.
1991: Jesús Pérez-Gil; Kevin M W Keough
Identical and similar amino acid sequences in the pulmonary surfactant proteins SP-B and SP-C and hemerythrin and myohemerythrin--an example of "biochemical Velcro"?
Biochemistry international 1991;25(4):715-21.
1991: Kaushik Nag; C Boland; N Rich; Kevin M W Keough
Epifluorescence microscopic observation of monolayers of dipalmitoylphosphatidylcholine: dependence of domain size on compression rates.
Biochimica et biophysica acta 1991;1068(2):157-60.
1991: N Kariel; E Davidson; Kevin M W Keough
Cholesterol does not remove the gel-liquid crystalline phase transition of phosphatidylcholines containing two polyenoic acyl chains.
Biochimica et biophysica acta 1991;1062(1):70-6.
1990: N Vrbjar; G A Simatos; Kevin M W Keough
Temperature dependence of kinetic parameters of (Ca2+ + Mg2+)-ATPase in rabbit and winter flounder sarcoplasmic reticulum.
Biochimica et biophysica acta 1990;1030(1):94-100.
1990: N Vrbjar; G Simatos; Kevin M W Keough
Ca2(+)-ATPase in sarcoplasmic reticulum from species adapted to warm and cold environments.
Biochemical Society transactions 1990;18(5):948.
1990: Kevin M W Keough
Influence of chain unsaturation and chain position on thermotropism and intermolecular interactions in membranes.
Biochemical Society transactions 1990;18(5):835-7.
1990: G A Simatos; K B Forward; Michael R Morrow; Kevin M W Keough
Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C.
Biochemistry 1990;29(24):5807-14.
1990: Kevin M W Keough; C S Parsons
Differential scanning calorimetry of dispersions of products of oxidation of 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(1):300-7.
1989: Kevin M W Keough; B Giffin; P L Matthews
Phosphatidylcholine-cholesterol interactions: bilayers of heteroacid lipids containing linoleate lose calorimetric transitions at low cholesterol concentration.
Biochimica et biophysica acta 1989;983(1):51-5.
1989: Garry Chernenko; J A Barrowman; K T Kean; G R Herzberg; Kevin M W Keough
Intestinal absorption and lymphatic transport of fish oil (MaxEPA) in the rat.
Biochimica et biophysica acta 1989;1004(1):95-102.
1989: Kevin M W Keough; C S Parsons; M G Tweeddale
Interactions between plasma proteins and pulmonary surfactant: pulsating bubble studies.
Canadian journal of physiology and pharmacology 1989;67(6):663-8.
1988: B D Fleming; Kevin M W Keough
Surface respreading after collapse of monolayers containing major lipids of pulmonary surfactant.
Chemistry and physics of lipids 1988;49(1-2):81-6.
1988: Kevin M W Keough; C S Parsons; P Terry Phang; M G Tweeddale
Interactions between plasma proteins and pulmonary surfactant: surface balance studies.
Canadian journal of physiology and pharmacology 1988;66(9):1166-73.
1988: Kevin M W Keough; M W Hawco; C S Parsons
The effect of methylation of phosphatidylethanolamine on the behaviour of lipid monolayers at the air-water interface.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(5):405-17.
1988: G B Smith; H W Taeusch; David S Phelps; Kevin M W Keough
Mixtures of low molecular weight surfactant proteins and dipalmitoyl phosphatidylcholine duplicate effects of pulmonary surfactant in vitro and in vivo.
Pediatric research 1988;23(5):484-90.
1987: Kevin M W Keough; N Kariel
Differential scanning calorimetric studies of aqueous dispersions of phosphatidylcholines containing two polyenoic chains.
Biochimica et biophysica acta 1987;902(1):11-8.
1987: Kevin M W Keough; B Giffin; N Kariel
The influence of unsaturation on the phase transition temperatures of a series of heteroacid phosphatidylcholines containing twenty-carbon chains.
Biochimica et biophysica acta 1987;902(1):1-10.
1986: H W Taeusch; Kevin M W Keough; M Williams; R Slavin; E Steele; A S Lee; D Phelps; N Kariel; Joanna Floros; M E Avery
Characterization of bovine surfactant for infants with respiratory distress syndrome.
Pediatrics 1986;77(4):572-81.
1986: P Terry Phang; Kevin M W Keough
Inhibition of pulmonary surfactant by plasma from normal adults and from patients having cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 1986;91(2):248-51.
1985: Kevin M W Keough; E Farrell; M Cox; G Harrell; H W Taeusch
Physical, chemical, and physiological characteristics of isolates of pulmonary surfactant from adult rabbits.
Canadian journal of physiology and pharmacology 1985;63(9):1043-51.
1983: K P Coolbear; Kevin M W Keough
Lipid oxidation and gel to liquid-crystalline transition temperatures of synthetic polyunsaturated mixed-acid phosphatidylcholines.
Biochimica et biophysica acta 1983;732(3):531-40.
1983: K P Coolbear; C B Berde; Kevin M W Keough
Gel to liquid-crystalline phase transitions of aqueous dispersions of polyunsaturated mixed-acid phosphatidylcholines.
Biochemistry 1983;22(6):1466-73.
1981: M W Hawco; K P Coolbear; P J Davis; Kevin M W Keough
Exclusion of fluid lipid during compression of monolayers of mixtures of dipalmitoylphosphatidylcholine with some other phosphatidylcholines.
Biochimica et biophysica acta 1981;646(1):185-7.
1981: M W Hawco; P J Davis; Kevin M W Keough
Lipid fluidity in lung surfactant: monolayers of saturated and unsaturated lecithins.
Journal of applied physiology: respiratory, environmental and exercise physiology 1981;51(2):509-15.
1981: P J Davis; B D Fleming; K P Coolbear; Kevin M W Keough
Gel to liquid-crystalline transition temperatures of water dispersions of two pairs of positional isomers of unsaturated mixed-acid phosphatidylcholines.
Biochemistry 1981;20(12):3633-6.
1980: P J Davis; K P Coolbear; Kevin M W Keough
Differential scanning calorimetric studies of the thermotropic phase behavior of membranes composed of dipalmitoyllecithin and mixed-acid unsaturated lecithins.
Canadian journal of biochemistry 1980;58(10):851-8.