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Bernhard Keppler

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Andrea Kurzwernhart; Maria Novak; Éva A Enyedy; Michael A Jakupec; Wolfgang Kandioller; Bernhard K Keppler; Christian G. Hartinger
3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands.
Wolfgang Kandioller; Bernhard K Keppler; Samuel M Meier; Alexander Roller; Evelyn Balsano; Walter Berger; Simone Göschl; Michael A Jakupec; Ute Jungwirth; Christian G. Hartinger
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
Maria V Babak; Mahsa S Adib Razavi; Michael A Jakupec; Bernhard K Keppler; Anton A Legin; Samuel M Meier; Alexander Roller; Christian G. Hartinger
Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development.

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2013: Andrea Kurzwernhart; Maria Novak; Éva A Enyedy; Michael A Jakupec; Wolfgang Kandioller; Bernhard K Keppler; Christian G. Hartinger
3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands.
Dalton transactions (Cambridge, England : 2003) 2013;42(17):6193-202.
2013: Wolfgang Kandioller; Bernhard K Keppler; Samuel M Meier; Alexander Roller; Evelyn Balsano; Walter Berger; Simone Göschl; Michael A Jakupec; Ute Jungwirth; Christian G. Hartinger
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
Chemical communications (Cambridge, England) 2013;49(32):3348-50.
2013: Maria V Babak; Mahsa S Adib Razavi; Michael A Jakupec; Bernhard K Keppler; Anton A Legin; Samuel M Meier; Alexander Roller; Christian G. Hartinger
Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(13):4308-18.
2013: Verena Pichler; Éva A Enyedy; Josef Mayr; Walter Berger; Orsolya Dömötör; Markus Galanksi; Diana Groza; Petra Heffeter; Gerrit Hermann; Bernhard K Keppler; Gunda Köllensperger; Christian Kowol
Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.
Chemical communications (Cambridge, England) 2013;49(22):2249-51.
2013: Alfred A Hummer; Michael A Jakupec; Bernhard K Keppler; David Batchelor; Walter Berger; Gabriel E Büchel; Martin Filipits; Petra Heffeter; Annette Rompel
X-ray absorption near edge structure spectroscopy to resolve the in vivo chemistry of the redox-active indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019).
Journal of medicinal chemistry 2013;56(3):1182-96.
2013: Seied Mojtaba Valiahdi; Kristof Meelich; Walter Miklos; Petra Nock; Walter Berger; Alexander E Egger; Markus Galanski; Christian G. Hartinger; Michael A Jakupec; Ute Jungwirth; Bernhard K Keppler
Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2013;18(2):249-60.
2013: Hristo P Varbanov; Alexander Roller; Markus Galanski; Michael A Jakupec; Frank Jensen; Bernhard K Keppler
Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes.
Journal of medicinal chemistry 2013;56(1):330-44.
2013: Orsolya Dömötör; Christian G. Hartinger; Bernhard K Keppler; Tamás Kiss; Anna K Bytzek; Eva Anna Enyedy
Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2013;18(1):9-17.
2012: Verena Pichler; Seied M Valiahdi; Christian Kowol; Walter Berger; Alexander Egger; Markus Galanski; Petra Heffeter; Michael A Jakupec; Bernhard K Keppler
Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity.
Journal of medicinal chemistry 2012;55(24):11052-61.
2012: Hristo P Varbanov; Markus Galanski; Michael A Jakupec; Christian Kowol; Seied M Valiahdi; Bernhard K Keppler
Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs.
Dalton transactions (Cambridge, England : 2003) 2012;41(47):14404-15.
2012: Andrea Kurzwernhart; Doris Marko; Sanela Martic; Gerhard Mühlgassner; Vladimir B Arion; Simone Bächler; Caroline Bartel; Patrick J Bednarski; Magdalena Buczkowska; Michael A Jakupec; Wolfgang Kandioller; Bernhard K Keppler; Heinz-Bernhard Kraatz; Christian G. Hartinger
Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands.
Journal of medicinal chemistry 2012;55(23):10512-22.
2012: Gerlinde Grabmann; Bernhard K Keppler; Samuel M Meier; Yulia Y Scaffidi-Domianello; Markus Galanski; Christian G. Hartinger
Capillary zone electrophoresis and capillary zone electrophoresis-electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions.
Journal of chromatography. A 2012;1267():156-61.
2012: Eva Anna Enyedy; Orsolya Dömötör; Christian G. Hartinger; Tamás Kiss; Robert Trondl; Erika Varga; Bernhard K Keppler
Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands.
Journal of inorganic biochemistry 2012;117():189-97.
2012: Gerhard Mühlgassner; Wolfgang F Schmid; Vladimir B Arion; Caroline Bartel; Michael A Jakupec; Bernhard K Keppler
Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells.
Journal of inorganic biochemistry 2012;116():180-7.
2012: Werner Ginzinger; Michael A Jakupec; Gerhard Mühlgassner; Vladimir B Arion; Walter Berger; Alexander Egger; Markus Galanski; Bernhard K Keppler
Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis.
Chemistry & biodiversity 2012;9(10):2175-85.
2012: Vladimir B Arion; Anatolie Dobrov; Simone Göschl; Michael A Jakupec; Bernhard K Keppler; Peter Rapta
Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs.
Chemical communications (Cambridge, England) 2012;48(68):8559-61.
2012: Miljan N M Milunovic; Nóra V Nagy; Ghenadie Novitchi; Robert Trondl; Éva A Enyedy; Michael A Jakupec; Bernhard K Keppler; Tamás Kiss; Regina Krachler; Vladimir B Arion
L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity.
Inorganic chemistry 2012;51(17):9309-21.
2012: Björn R Hoffmeister; Michael A Jakupec; Mahsa S Adib-Razavi; Markus Galanski; Bernhard K Keppler
Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity.
Chemistry & biodiversity 2012;9(9):1840-8.
2012: Helena Henke; Wolfgang Kandioller; Bernhard K Keppler; Muhammad Hanif; Christian G. Hartinger
Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents.
Chemistry & biodiversity 2012;9(9):1718-27.
2012: Gabriel E Büchel; Petra Heffeter; Michaela Hejl; Michael A Jakupec; Bernhard K Keppler; Iryna N Stepanenko; Walter Berger; Vladimir B Arion
Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity.
Journal of inorganic biochemistry 2012;113():47-54.
2012: Yulia Yu Scaffidi-Domianello; Markus Galanski; Michael A Jakupec; Vadim Yu Kukushkin; Anton A Legin; Alexander Roller; Bernhard K Keppler
Novel oximato-bridged platinum(II) di- and trimer(s): synthetic, structural, and in vitro anticancer activity studies.
Inorganic chemistry 2012;51(13):7153-63.
2012: Petra Heffeter; Gerrit Herrman; Ute Jungwirth; Bernhard K Keppler; Gunda Koellensperger; Christian Kowol; Walter Miklos; Christine Pirker; Rita Dornetshuber; Walter Berger
Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.
Biochemical pharmacology 2012;83(12):1623-33.
2012: Alfred A Hummer; Michael A Jakupec; Bernhard K Keppler; Wolfram Meyer-Klaucke; Ana Mijovilovich; Paul D Quinn; Vladimir B Arion; Caroline Bartel; Tina Geraki; Annette Rompel
X-ray absorption spectroscopy of an investigational anticancer gallium(III) drug: interaction with serum proteins, elemental distribution pattern, and coordination of the compound in tissue.
Journal of medicinal chemistry 2012;55(11):5601-13.
2012: Irina Buß; Markus Galanski; Ganna V Kalayda; Bernhard K Keppler; Andreas Lindauer; Michael R Reithofer; Ulrich Jaehde
Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(5):699-708.
2012: Andrea Kurzwernhart; Doris Marko; Gerhard Mühlgassner; Robert Trondl; Vladimir B Arion; Simone Bächler; Caroline Bartel; Michael A Jakupec; Wolfgang Kandioller; Bernhard K Keppler; Christian G. Hartinger
Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.
Chemical communications (Cambridge, England) 2012;48(40):4839-41.
2012: Ute Jungwirth; Bernhard K Keppler; Wilfried Körner; Ursula Windberger; Dimitris Xanthos; Anna K Bytzek; Markus Galanski; Johannes Gojo; Christian G. Hartinger; Petra Heffeter; Michael A Jakupec; Sergey A Abramkin; Walter Berger
Anticancer activity of methyl-substituted oxaliplatin analogs.
Molecular pharmacology 2012;81(5):719-28.
2012: Oliver Brandt; Alexander E Egger; Michael Groessl; Bernhard K Keppler; Michael Mildner; Beat Mueller; Martin Posch; Uwe Rix; Christian Strupp; Georg Stingl
Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine.
Nanomedicine : nanotechnology, biology, and medicine 2012;8(4):478-88.
2012: Werner Ginzinger; Michael A Jakupec; Vladimir B Arion; Walter Berger; Markus Galanski; Gerhard Mühlgassner; Michael Reithofer; Alexander Roller; Bernhard K Keppler
A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines.
Journal of medicinal chemistry 2012;55(7):3398-413.
2012: Sergey Abramkin; Markus Galanski; Michael A Jakupec; Nils Metzler-Nolte; Seied M Valiahdi; Bernhard K Keppler
Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates.
Dalton transactions (Cambridge, England : 2003) 2012;41(10):3001-5.
2012: Samuel M Meier; Muhammad Hanif; Wolfgang Kandioller; Bernhard K Keppler; Christian G. Hartinger
Biomolecule binding vs. anticancer activity: reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins.
Journal of inorganic biochemistry 2012;108():91-5.
2012: Caroline Bartel; Anna K Bytzek; Markus Galanski; Gerlinde Grabmann; Christian G. Hartinger; Michael A Jakupec; Yulia Yu Scaffidi-Domianello; Bernhard K Keppler
Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(3):465-74.
2012: Christian Kowol; Walter Miklos; Robert Trondl; Walter Berger; Loredana Cappellacci; Lars Gille; Petra Heffeter; Bernhard K Keppler
Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(3):409-23.
2012: Samuel M Meier; Yury O Tsybin; Paul J Dyson; Bernhard K Keppler; Christian G. Hartinger
Fragmentation methods on the balance: unambiguous top-down mass spectrometric characterization of oxaliplatin-ubiquitin binding sites.
Analytical and bioanalytical chemistry 2012;402(8):2655-62.
2011: Caroline Bartel; Walter Berger; Alexander E Egger; Markus Galanski; Petra Heffeter; Michael A Jakupec; Bernhard K Keppler
Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(8):1205-15.
2011: Yun Zhang; Franz Jirsa; Daniel Kogelnig; Regina Krachler; Yanfeng Li; Irene Lichtscheidl-Schultz; Cornelia Morgenbesser; Anja Stojanovic; Bernhard K Keppler
Preparation and characterization of immobilized [A336][MTBA] in PVA-alginate gel beads as novel solid-phase extractants for an efficient recovery of Hg (II) from aqueous solutions.
Journal of hazardous materials 2011;196():201-9.
2011: Iryna N Stepanenko; Gerhard Mühlgassner; Maria S Novak; Alexander Roller; Vladimir B Arion; Michaela Hejl; Michael A Jakupec; Bernhard K Keppler
Organometallic 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as potential anticancer agents.
Inorganic chemistry 2011;50(22):11715-28.
2011: Yulia Yu Scaffidi-Domianello; Vadim Yu Kukushkin; Anton A Legin; Vladimir B Arion; Markus Galanski; Michael A Jakupec; Bernhard K Keppler
Synthesis, characterization, and cytotoxic activity of novel potentially pH-sensitive nonclassical platinum(II) complexes featuring 1,3-dihydroxyacetone oxime ligands.
Inorganic chemistry 2011;50(21):10673-81.
2011: Hristo Varbanov; Markus Galanski; Michael A Jakupec; Anton A Legin; Alexander Roller; Seied M Valiahdi; Bernhard K Keppler
Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin.
European journal of medicinal chemistry 2011;46(11):5456-64.
2011: Anna K Bytzek; Stephan Hann; Christian G. Hartinger; Gerrit Hermann; Bernhard K Keppler; Katharina Boeck; Gunda Koellensperger
LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma.
Metallomics : integrated biometal science 2011;3(10):1049-55.
2011: Lisa Fischer; Markus Galanski; Thomas Falta; Bernhard K Keppler; Gunda Koellensperger; Daniel Kogelnig; Regina Krachler; Anja Stojanovic; Stephan Hann
Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water.
Water research 2011;45(15):4601-14.
2011: Verena Pichler; Seied M Valiahdi; Vladimir B Arion; Markus Galanski; Michael A Jakupec; Bernhard K Keppler
Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity.
Dalton transactions (Cambridge, England : 2003) 2011;40(32):8187-92.
2011: Gabriel E Büchel; Michaela Hejl; Michael A Jakupec; Bernhard K Keppler; Iryna N Stepanenko; Vladimir B Arion
En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2].
Inorganic chemistry 2011;50(16):7690-7.
2011: Ute Jungwirth; Bernhard K Keppler; Christian Kowol; Walter Berger; Christian G. Hartinger; Petra Heffeter
Anticancer activity of metal complexes: involvement of redox processes.
Antioxidants & redox signaling 2011;15(4):1085-127.
2011: Eva Anna Enyedy; Christian G. Hartinger; Anasztázia Hetényi; László Horváth; Bernhard K Keppler; Tiziano Tuccinardi; Tamás Kiss
Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies.
Bioorganic & medicinal chemistry 2011;19(14):4202-10.
2011: Lidia S Foteeva; Denis A Trofimov; Olga V Kuznetsova; Christian Kowol; Vladimir B Arion; Bernhard K Keppler; Andrei R Timerbaev
A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography.
Journal of pharmaceutical and biomedical analysis 2011;55(3):409-13.
2011: Irina Buss; Markus Galanski; Dirk Garmann; Ganna V Kalayda; Bernhard K Keppler; Günther Weber; Ulrich Jaehde
Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes?
Journal of inorganic biochemistry 2011;105(5):709-17.
2011: Johanna Ungersboeck; Cécile Philippe; Leonhard-Key Mien; Daniela Haeusler; Karem Shanab; Rupert Lanzenberger; Helmut Spreitzer; Bernhard K Keppler; Robert Dudczak; Kurt Kletter; Markus Mitterhauser; Wolfgang Wadsak
Microfluidic preparation of [18F]FE@SUPPY and [18F]FE@SUPPY:2--comparison with conventional radiosyntheses.
Nuclear medicine and biology 2011;38(3):427-34.
2011: Patrick Bippus; Matthias Skocic; Michael A Jakupec; Bernhard K Keppler; Fabian Mohr
Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates.
Journal of inorganic biochemistry 2011;105(3):462-6.
2011: Amitava Kundu; Herwig Peterlik; Martin Krssak; Anna K Bytzek; Irena Pashkunova-Martic; Vladimir B Arion; Thomas H Helbich; Bernhard K Keppler
Strategies for the covalent conjugation of a bifunctional chelating agent to albumin: synthesis and characterization of potential MRI contrast agents.
Journal of inorganic biochemistry 2011;105(2):250-5.
2011: Muhammad Hanif; Samuel M Meier; Wolfgang Kandioller; Anna Bytzek; Michaela Hejl; Christian G. Hartinger; Alexey A Nazarov; Vladimir B Arion; Michael A Jakupec; Paul J Dyson; Bernhard K Keppler
From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands.
Journal of inorganic biochemistry 2011;105(2):224-31.
2011: Michael R Reithofer; Anna K Bytzek; Seied M Valiahdi; Christian Kowol; Michael Groessl; Christian G. Hartinger; Michael A Jakupec; Markus Galanski; Bernhard K Keppler
Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes.
Journal of inorganic biochemistry 2011;105(1):46-51.
2010: Michael F Primik; Simone Göschl; Michael A Jakupec; Alexander Roller; Bernhard K Keppler; Vladimir B Arion
Structure-activity relationships of highly cytotoxic copper(II) complexes with modified indolo[3,2-c]quinoline ligands.
Inorganic chemistry 2010;49(23):11084-95.
2010: Sergey A Abramkin; Ute Jungwirth; Seied M Valiahdi; Claudia Dworak; Ladislav Habala; Kristof Meelich; Walter Berger; Michael A Jakupec; Christian G. Hartinger; Alexey A Nazarov; Markus Galanski; Bernhard K Keppler
{(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo.
Journal of medicinal chemistry 2010;53(20):7356-64.
2010: Muhammad Hanif; Helena Henke; Samuel M Meier; Sanela Martic; Mahmoud Labib; Wolfgang Kandioller; Michael A Jakupec; Vladimir B Arion; Heinz-Bernhard Kraatz; Bernhard K Keppler; Christian G. Hartinger
Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter?
Inorganic chemistry 2010;49(17):7953-63.
2010: Muhammad Hanif; Alexey A Nazarov; Christian G. Hartinger; Wolfgang Kandioller; Michael A Jakupec; Vladimir B Arion; Paul J Dyson; Bernhard K Keppler
Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences.
Dalton transactions (Cambridge, England : 2003) 2010;39(31):7345-52.
2010: Lukas K Filak; Gerhard Mühlgassner; Michael A Jakupec; Petra Heffeter; Walter Berger; Vladimir B Arion; Bernhard K Keppler
Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(6):903-18.
2010: Yulia Yu Scaffidi-Domianello; Kristof Meelich; Michael A Jakupec; Vladimir B Arion; Vadim Yu Kukushkin; Markus Galanski; Bernhard K Keppler
Novel cis- and trans-configured bis(oxime)platinum(II) complexes: synthesis, characterization, and cytotoxic activity.
Inorganic chemistry 2010;49(12):5669-78.
2010: Petra Heffeter; Katharina Böck; Bihter Atil; Mir Ali Reza Hoda; Wilfried Körner; Caroline Bartel; Ute Jungwirth; Bernhard K Keppler; Michael Micksche; Walter Berger; Gunda Koellensperger
Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(5):737-48.
2010: Michael Groessl; Yury O Tsybin; Christian G. Hartinger; Bernhard K Keppler; Paul J Dyson
Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(5):677-88.
2010: Regina Krachler; Rudolf F Krachler; Frank von der Kammer; Altan Süphandag; Franz Jirsa; Shahram Ayromlou; Thilo Hofmann; Bernhard K Keppler
Relevance of peat-draining rivers for the riverine input of dissolved iron into the ocean.
The Science of the total environment 2010;408(11):2402-8.
2010: Vesna M Djinovic; Markus Galanski; Vladimir B Arion; Bernhard K Keppler
Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes.
Dalton transactions (Cambridge, England : 2003) 2010;39(15):3633-43.
2010: Anna K Bytzek; Michael R Reithofer; Markus Galanski; Michael Groessl; Bernhard K Keppler; Christian G. Hartinger
The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes.
Electrophoresis 2010;31(7):1144-50.
2010: Christian Kowol; Robert Trondl; Vladimir B Arion; Michael A Jakupec; Irene Lichtscheidl; Bernhard K Keppler
Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.
Dalton transactions (Cambridge, England : 2003) 2010;39(3):704-6.
2010: Michael F Primik; Gerhard Mühlgassner; Michael A Jakupec; olivier zava; Paul J Dyson; Vladimir B Arion; Bernhard K Keppler
Highly cytotoxic copper(II) complexes with modified paullone ligands.
Inorganic chemistry 2010;49(1):302-11.
2009: Esther Schuh; Seied M Valiahdi; Michael A Jakupec; Bernhard K Keppler; Peter Chiba; Fabian Mohr
Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes.
Dalton transactions (Cambridge, England : 2003) 2009;(48):10841-5.
2009: Florian Biba; Michael Groessl; Alexander Egger; Michael A Jakupec; Bernhard K Keppler
A novel cytotoxic cerium complex: aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, characterization, behavior in H2O, binding towards biomolecules, and antiproliferative activity.
Chemistry & biodiversity 2009;6(12):2153-65.
2009: Anna K Bytzek; Eva A Enyedy; Tamás Kiss; Bernhard K Keppler; Christian G. Hartinger
Biodistribution of anti-diabetic Zn(II) complexes in human serum and in vitro protein-binding studies by means of CZE-ICP-MS.
Electrophoresis 2009;30(23):4075-82.
2009: Gabriel E Büchel; Iryna N Stepanenko; Michaela Hejl; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
[Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity.
Inorganic chemistry 2009;48(22):10737-47.
2009: Wolfgang Kandioller; Christian G. Hartinger; Alexey A Nazarov; Caroline Bartel; Matthias Skocic; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(45):12283-91.
2009: Seied Mojtaba Valiahdi; Petra Heffeter; Michael A Jakupec; Rodrig Marculescu; Walter Berger; Klemens Rappersberger; Bernhard K Keppler
The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines.
Melanoma research 2009;19(5):283-93.
2009: Christian Kowol; Robert Trondl; Petra Heffeter; Vladimir B Arion; Michael A Jakupec; Alexander Roller; Markus Galanski; Walter Berger; Bernhard K Keppler
Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.
Journal of medicinal chemistry 2009;52(16):5032-43.
2009: Petra Heffeter; A Popovic-Bijelic; Philipp Saiko; R Dornetshuber; U Jungwirth; Nina Voevodskaya; D Biglino; Michael A Jakupec; Leonilla Elbling; Michael Micksche; Thomas Szekeres; Bernhard K Keppler; Astrid Gräslund; Walter Berger
Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).
Current cancer drug targets 2009;9(5):595-607.
2009: Johanna Kasser; Alexey A Nazarov; Christian G. Hartinger; Brigitte Wdziekonski; Christian Dani; Maxim L Kuznetsov; Vladimir B Arion; Bernhard K Keppler
A one step/one pot synthesis of N,N-bis(phosphonomethyl)amino acids and their effects on adipogenic and osteogenic differentiation of human mesenchymal stem cells.
Bioorganic & medicinal chemistry 2009;17(9):3388-93.
2009: Maria G Mendoza-Ferri; Christian G. Hartinger; Marco A Mendoza; Michael Groessl; Alexander E Egger; Rene E Eichinger; John B Mangrum; Nicholas P Farrell; Magdalena Maruszak; Patrick J Bednarski; Franz Klein; Michael A Jakupec; Alexey A Nazarov; Kay Severin; Bernhard K Keppler
Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity.
Journal of medicinal chemistry 2009;52(4):916-25.
2008: Christian Kowol; Erwin Reisner; Ion Chiorescu; Vladimir B Arion; Markus Galanski; Dirk V Deubel; Bernhard K Keppler
An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones.
Inorganic chemistry 2008;47(23):11032-47.
2008: Michael R Reithofer; Anne Schwarzinger; Seied M Valiahdi; Markus Galanski; Michael A Jakupec; Bernhard K Keppler
Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity.
Journal of inorganic biochemistry 2008;102(12):2072-7.
2008: Daniel Dolfen; Kristina Schottler; Seied-Mojtaba Valiahdi; Michael A Jakupec; Bernhard K Keppler; Edward R T Tiekink; Fabian Mohr
Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters.
Journal of inorganic biochemistry 2008;102(12):2067-71.
2008: Alexander E Egger; Christian G. Hartinger; Hisham Ben Hamidane; Yury O Tsybin; Bernhard K Keppler; Paul J Dyson
High resolution mass spectrometry for studying the interactions of cisplatin with oligonucleotides.
Inorganic chemistry 2008;47(22):10626-33.
2008: Anja Stojanovic; Michael Lämmerhofer; Daniel Kogelnig; Simone Schiesel; Martin Sturm; Markus Galanski; Regina Krachler; Bernhard K Keppler; Wolfgang Lindner
Analysis of quaternary ammonium and phosphonium ionic liquids by reversed-phase high-performance liquid chromatography with charged aerosol detection and unified calibration.
Journal of chromatography. A 2008;1209(1-2):179-87.
2008: Michael R Reithofer; Seied M Valiahdi; Markus Galanski; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Novel endothall-containing platinum(IV) complexes: synthesis, characterization, and cytotoxic activity.
Chemistry & biodiversity 2008;5(10):2160-70.
2008: Shaheen M Ashraf; Wolfgang Kandioller; Maria-Grazia Mendoza-Ferri; Alexey A Nazarov; Christian G. Hartinger; Bernhard K Keppler
The hydration of chloroacetonitriles catalyzed by mono- and dinuclear Ru(II)- and Os(II)-arene complexes.
Chemistry & biodiversity 2008;5(10):2060-6.
2008: Christian G. Hartinger; Michael A Jakupec; Stefanie Zorbas-Seifried; Michael Groessl; Alexander Egger; Walter Berger; Haralabos Zorbas; Paul J Dyson; Bernhard K Keppler
KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients.
Chemistry & biodiversity 2008;5(10):2140-55.
2008: Lidia S Foteeva; Natalya V Stolyarova; Andrei R Timerbaev; Bernhard K Keppler
Capillary electrophoretic assay for the stability of tris(8-quinolinolato)gallium(III) in tablet formulations.
Journal of pharmaceutical and biomedical analysis 2008;48(1):218-22.
2008: Claudine Scolaro; Christian G. Hartinger; claire allardyce; Bernhard K Keppler; Paul J Dyson
Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta6-p-cymene)Cl2(pta)].
Journal of inorganic biochemistry 2008;102(9):1743-8.
2008: Iryna N Stepanenko; Artem A Krokhin; Roland O John; Alexander Roller; Vladimir B Arion; Michael A Jakupec; Bernhard K Keppler
Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles.
Inorganic chemistry 2008;47(16):7338-47.
2008: Alexei Y Shmykov; Vladimir N Filippov; Lidia S Foteeva; Bernhard K Keppler; Andrei R Timerbaev
Toward high-throughput monitoring of metallodrug-protein interaction using capillary electrophoresis in chemically modified capillaries.
Analytical biochemistry 2008;379(2):216-8.
2008: Shaheen M Ashraf; Isabella Berger; Alexey A Nazarov; Christian G. Hartinger; Mikhail P Koroteev; Eduard E Nifant'ev; Bernhard K Keppler
Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles. short communication.
Chemistry & biodiversity 2008;5(8):1640-4.
2008: Alexander Egger; Berta Cebrián-Losantos; Iryna N Stepanenko; Artem A Krokhin; Rene Eichinger; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication.
Chemistry & biodiversity 2008;5(8):1588-93.
2008: Michael Groessl; Christian G. Hartinger; Kasia Połeć-Pawlak; Katarzyna (Kasia) Pawlak; Paul J Dyson; Bernhard K Keppler
Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication.
Chemistry & biodiversity 2008;5(8):1609-14.
2008: Berta Cebrián-Losantos; Erwin Reisner; Christian Kowol; Alexander Roller; Sergiu Shova; Vladimir B Arion; Bernhard K Keppler
Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-.
Inorganic chemistry 2008;47(14):6513-23.
2008: Kasia Połeć-Pawlak; Jan K Abramski; Julia Ferenc; Lidia S Foteeva; Andrei R Timerbaev; Bernhard K Keppler; Katarzyna (Kasia) Pawlak
Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins.
Journal of chromatography. A 2008;1192(2):323-6.
2008: Michael Groessl; Christian G. Hartinger; Kasia Polec-Pawlak; Katarzyna (Kasia) Pawlak; Bernhard K Keppler
Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma.
Electrophoresis 2008;29(10):2224-32.
2008: Michael Groessl; Christian G. Hartinger; Paul J Dyson; Bernhard K Keppler
CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP.
Journal of inorganic biochemistry 2008;102(5-6):1060-5.
2008: Antoine Dorcier; Christian G. Hartinger; Rosario Scopelliti; Richard H Fish; Bernhard K Keppler; Paul J Dyson
Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds.
Journal of inorganic biochemistry 2008;102(5-6):1066-76.
2008: Michael R Reithofer; Markus Galanski; Vladimir B Arion; Bernhard K Keppler
Unprecedented twofold intramolecular hydroamination in diam(m)ine-dicarboxylatodichloridoplatinum(IV) complexes - ethane-1,2-diamine vs. ammine ligands.
Chemical communications (Cambridge, England) 2008;(9):1091-3.
2008: Petra Heffeter; Ute Jungwirth; Michael Jakupec; Christian G. Hartinger; Markus Galanski; Leonilla Elbling; Michael Micksche; Bernhard K Keppler; Walter Berger
Resistance against novel anticancer metal compounds: differences and similarities.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2008;11(1-2):1-16.
2008: Michael A Jakupec; Markus Galanski; Vladimir B Arion; Christian G. Hartinger; Bernhard K Keppler
Antitumour metal compounds: more than theme and variations.
Dalton transactions (Cambridge, England : 2003) 2008;(2):183-94.
2008: Christian G. Hartinger; Alexey A Nazarov; Shaheen M Ashraf; Paul J Dyson; Bernhard K Keppler
Carbohydrate-metal complexes and their potential as anticancer agents.
Current medicinal chemistry 2008;15(25):2574-91.
2008: Isabella Berger; Muhammad Hanif; Alexey A Nazarov; Christian G. Hartinger; Roland O John; Maxim L Kuznetsov; Michael Groessl; Frederic Schmitt; olivier zava; Florian Biba; Vladimir B Arion; Markus Galanski; Michael A Jakupec; Lucienne Juillerat-Jeanneret; Paul J Dyson; Bernhard K Keppler
In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(29):9046-57.
2008: Wolfgang Wadsak; Leonhard-Key Mien; Karem Shanab; Dagmar E Ettlinger; Daniela Haeusler; Karoline Sindelar; Rupert Lanzenberger; Helmut Spreitzer; Helmut Viernstein; Bernhard K Keppler; Robert Dudczak; Kurt Kletter; Markus Mitterhauser
Preparation and first evaluation of [(18)F]FE@SUPPY: a new PET tracer for the adenosine A(3) receptor.
Nuclear medicine and biology 2008;35(1):61-6.
2007: Michael R Reithofer; Seied M Valiahdi; Michael A Jakupec; Vladimir B Arion; Alexander Egger; Markus Galanski; Bernhard K Keppler
Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination.
Journal of medicinal chemistry 2007;50(26):6692-9.
2007: Walther Schmid; Roland O John; Gerhard Mühlgassner; Petra Heffeter; Michael A Jakupec; Markus Galanski; Walter Berger; Vladimir B Arion; Bernhard K Keppler
Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy.
Journal of medicinal chemistry 2007;50(25):6343-55.
2007: Claudine Scolaro; Adrian B Chaplin; Christian G. Hartinger; Alberta Bergamo; Moreno Cocchietto; Bernhard K Keppler; Gianni Sava; Paul J Dyson
Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy.
Dalton transactions (Cambridge, England : 2003) 2007;(43):5065-72.
2007: Wolfgang Wadsak; Leonhard-Key Mien; Dagmar E Ettlinger; Harald Eidherr; Daniela Haeusler; Karoline-Maria Sindelar; Bernhard K Keppler; Robert Dudczak; Kurt Kletter; Markus Mitterhauser
18F fluoroethylations: different strategies for the rapid translation of 11C-methylated radiotracers.
Nuclear medicine and biology 2007;34(8):1019-28.
2007: Christian Kowol; Rene Eichinger; Michael A Jakupec; Markus Galanski; Vladimir B Arion; Bernhard K Keppler
Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.
Journal of inorganic biochemistry 2007;101(11-12):1946-57.
2007: Christian G. Hartinger; Bernhard K Keppler
CE in anticancer metallodrug research--an update.
Electrophoresis 2007;28(19):3436-46.
2007: Andrei R Timerbaev; Bernhard K Keppler
Capillary electrophoresis of metal-based drugs.
Analytical biochemistry 2007;369(1):1-7.
2007: Vladimir O Gelmboldt; Eduard V Ganin; Marina S Fonari; Yurii A Simonov; Larisa V Koroeva; Alim A Ennan; Stepan S Basok; Sergiu Shova; Hanspeter Kählig; Vladimir B Arion; Bernhard K Keppler
Two new "onium" fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: structures and spectroscopic properties.
Dalton transactions (Cambridge, England : 2003) 2007;(27):2915-24.
2007: Svetlana S Aleksenko; Christian G. Hartinger; Olga Semenova; Kristof Meelich; Andrei R Timerbaev; Bernhard K Keppler
Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis.
Journal of chromatography. A 2007;1155(2):218-21.
2007: Andrei R Timerbaev; Lidia S Foteeva; Alexander V Rudnev; Jan K Abramski; Katarzyna Połeć-Pawlak; Christian G. Hartinger; Katarzyna (Kasia) Pawlak; Bernhard K Keppler
Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE.
Electrophoresis 2007;28(13):2235-40.
2007: Petra Heffeter; Michael A Jakupec; Wilfried Körner; Peter Chiba; Christine Pirker; R Dornetshuber; Leonilla Elbling; Hedwig Sutterlüty; Michael Micksche; Bernhard K Keppler; Walter Berger
Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).
Biochemical pharmacology 2007;73(12):1873-86.
2007: Berta Cebrián-Losantos; Artem A Krokhin; Iryna N Stepanenko; Rene Eichinger; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties.
Inorganic chemistry 2007;46(12):5023-33.
2007: Yulia Yu Scaffidi-Domianello; Alexey A Nazarov; Matti Haukka; Markus Galanski; Bernhard K Keppler; Jacob Schneider; Pingwu Du; Richard Eisenberg; Vadim Yu Kukushkin
First example of the solid-state thermal cyclometalation of ligated benzophenone imine giving novel luminescent platinum(II) species.
Inorganic chemistry 2007;46(11):4469-82.
2007: Michael Groessl; Erwin Reisner; Christian G. Hartinger; Rene Eichinger; Olga Semenova; Andrei R Timerbaev; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity.
Journal of medicinal chemistry 2007;50(9):2185-93.
2007: Walther Schmid; Stefanie Zorbas-Seifried; Roland O John; Vladimir B Arion; Michael A Jakupec; Alexander Roller; Markus Galanski; Ion Chiorescu; Haralabos Zorbas; Bernhard K Keppler
The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro.
Inorganic chemistry 2007;46(9):3645-56.
2007: Isabella Berger; Alexey A Nazarov; Christian G. Hartinger; Michael Groessl; Seied-M Valiahdi; Michael A Jakupec; Bernhard K Keppler
A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?
ChemMedChem 2007;2(4):505-14.
2007: Christian Kowol; Roland Berger; Rene Eichinger; Alexander Roller; Michael A Jakupec; Peter P Schmidt; Vladimir B Arion; Bernhard K Keppler
Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase.
Journal of medicinal chemistry 2007;50(6):1254-65.
2007: Andrei R Timerbaev; Oksana O Vasylenko; Lidia S Foteeva; Alexander V Rudnev; Olga Semenova; Bernhard K Keppler
Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance.
Journal of separation science 2007;30(3):399-406.
2007: Markus Galanski; Bernhard K Keppler
Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue.
Anti-cancer agents in medicinal chemistry 2007;7(1):55-73.
2007: Stefanie Zorbas-Seifried; Michael A Jakupec; Nikolay V Kukushkin; Michael Groessl; Christian G. Hartinger; Olga Semenova; Haralabos Zorbas; Vadim Yu Kukushkin; Bernhard K Keppler
Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands.
Molecular pharmacology 2007;71(1):357-65.
2006: Stefanie Zorbas-Seifried; Christian G. Hartinger; Kristof Meelich; Markus Galanski; Bernhard K Keppler; Haralabos Zorbas
DNA interactions of pH-sensitive, antitumor bis(aminoalcohol)dichloroplatinum(II) complexes.
Biochemistry 2006;45(49):14817-25.
2006: Alexander V Rudnev; Lidia S Foteeva; Christian Kowol; Roland Berger; Michael A Jakupec; Vladimir B Arion; Andrei R Timerbaev; Bernhard K Keppler
Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins.
Journal of inorganic biochemistry 2006;100(11):1819-26.
2006: Andrei R Timerbaev; Christian G. Hartinger; Svetlana S Aleksenko; Bernhard K Keppler
Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.
Chemical reviews 2006;106(6):2224-48.
2006: Christian G. Hartinger; Stefanie Zorbas-Seifried; Michael A Jakupec; Bernd Kynast; Haralabos Zorbas; Bernhard K Keppler
From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).
Journal of inorganic biochemistry 2006;100(5-6):891-904.
2006: Petra Schluga; Christian G. Hartinger; Alexander Egger; Erwin Reisner; Markus Galanski; Michael A Jakupec; Bernhard K Keppler
Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP.
Dalton transactions (Cambridge, England : 2003) 2006;(14):1796-802.
2006: Anatoly Dobrov; Vladimir B Arion; Norbert Kandler; Werner Ginzinger; Michael A Jakupec; Anna Rufińska; Nikolai Graf von Keyserlingk; Markus Galanski; Christian Kowol; Bernhard K Keppler
The first metal-based paullone derivative with high antiproliferative activity in vitro.
Inorganic chemistry 2006;45(5):1945-50.
2006: Kasia Polec-Pawlak; Jan K Abramski; Olga Semenova; Christian G. Hartinger; Andrei R Timerbaev; Bernhard K Keppler; Katarzyna (Kasia) Pawlak
Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins.
Electrophoresis 2006;27(5-6):1128-35.
2006: Wolfgang Wadsak; Barbara Wirl-Sagadin; Markus Mitterhauser; Leonhard-Key Mien; Dagmar E Ettlinger; Bernhard K Keppler; Robert Dudczak; Kurt Kletter
NCA nucleophilic radiofluorination on substituted benzaldehydes for the preparation of [18F]fluorinated aromatic amino acids.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2006;64(3):355-9.
2006: Petra Heffeter; Michael A Jakupec; Wilfried Körner; Stefan Wild; Nikolai Graf von Keyserlingk; Leonilla Elbling; Haralabos Zorbas; Alla Korynevska; Siegfried Knasmüller; Hedwig Sutterlüty; Michael Micksche; Bernhard K Keppler; Walter Berger
Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).
Biochemical pharmacology 2006;71(4):426-40.
2006: Markus Galanski; Bernhard K Keppler
[Development, importance and perspectives. Tumor inhibiting metal compounds].
Pharmazie in unserer Zeit 2006;35(2):118-23.
2005: Michael A Jakupec; Vladimir B Arion; Susanne Kapitza; Erwin Reisner; Anna Eichinger; Martina Pongratz; Brigitte Marian; Nikolai Graf von Keyserlingk; Bernhard K Keppler
KP1019 (FFC14A) from bench to bedside: preclinical and early clinical development--an overview.
International journal of clinical pharmacology and therapeutics 2005;43(12):595-6.
2005: Ralf-Dieter Hofheinz; Christian Dittrich; Michael A Jakupec; A Drescher; Ulrich Jaehde; Margit Gneist; Nikolai Graf von Keyserlingk; Bernhard K Keppler; Andreas Hochhaus
Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors--a CESAR study (Central European Society for Anticancer Drug Research--EWIV).
International journal of clinical pharmacology and therapeutics 2005;43(12):590-1.
2005: Christian G. Hartinger; Stephan Hann; Gunda Koellensperger; M Sulyok; Michael Groessl; Andrei R Timerbaev; Alexander V Rudnev; Gerhard Stingeder; Bernhard K Keppler
Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins--significance for the patient.
International journal of clinical pharmacology and therapeutics 2005;43(12):583-5.
2005: Markus Galanski; Ladislav Habala; Alexey A Nazarov; Michael A Jakupec; Afshin Yasemi; Susanna Slaby; Nikolai Graf von Keyserlingk; Bernhard K Keppler
Rational development of oxaliplatin analogues --synthesis and preliminary structure-activity relationships.
International journal of clinical pharmacology and therapeutics 2005;43(12):575-6.
2005: Ladislav Habala; Markus Galanski; Afshin Yasemi; Alexey A Nazarov; Nikolai Graf von Keyserlingk; Bernhard K Keppler
Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives.
European journal of medicinal chemistry 2005;40(11):1149-55.
2005: Petra Schluga; Christian G. Hartinger; Markus Galanski; Kristof Meelich; Andrei R Timerbaev; Bernhard K Keppler
Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry.
The Analyst 2005;130(10):1383-9.
2005: Erwin Reisner; Vladimir B Arion; Anna Eichinger; Norbert Kandler; Gerald Giester; Armando J L Pombeiro; Bernhard K Keppler
Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes.
Inorganic chemistry 2005;44(19):6704-16.
2005: Susanne Kapitza; Michael A Jakupec; Maria Uhl; Bernhard K Keppler; Brigitte Marian
The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells.
Cancer letters 2005;226(2):115-21.
2005: Erwin Reisner; Vladimir B Arion; Anna Rufińska; Ion Chiorescu; Walther Schmid; Bernhard K Keppler
Isomeric [RuCl2(dmso)2(indazole)2] complexes: ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole.
Dalton transactions (Cambridge, England : 2003) 2005;(14):2355-64.
2005: Haralabos Zorbas; Bernhard K Keppler
Cisplatin damage: are DNA repair proteins saviors or traitors to the cell?
Chembiochem : a European journal of chemical biology 2005;6(7):1157-66.
2005: Andrei R Timerbaev; Alexander V Rudnev; Olga Semenova; Christian G. Hartinger; Bernhard K Keppler
Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis.
Analytical biochemistry 2005;341(2):326-33.
2005: Michael A Jakupec; Erwin Reisner; Anna Eichinger; Martina Pongratz; Vladimir B Arion; Markus Galanski; Christian G. Hartinger; Bernhard K Keppler
Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential.
Journal of medicinal chemistry 2005;48(8):2831-7.
2005: Alexander V Rudnev; Svetlana S Aleksenko; Olga Semenova; Christian G. Hartinger; Andrei R Timerbaev; Bernhard K Keppler
Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method.
Journal of separation science 2005;28(2):121-7.
2005: Christina Rappel; Markus Galanski; Afshin Yasemi; Ladislav Habala; Bernhard K Keppler
Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients.
Electrophoresis 2005;26(4-5):878-84.
2005: Susanne Kapitza; Martina Pongratz; Michael A Jakupec; Petra Heffeter; Walter Berger; L Lackinger; Bernhard K Keppler; Brigitte Marian
Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells.
Journal of cancer research and clinical oncology 2005;131(2):101-10.
2005: Alexander Egger; Vladimir B Arion; Erwin Reisner; Berta Cebrián-Losantos; Sergiu Shova; Günter Trettenhahn; Bernhard K Keppler
Reactions of potent antitumor complex trans-[Ru(III)Cl4(indazole)2]- with a DNA-relevant nucleobase and thioethers: insight into biological action.
Inorganic chemistry 2005;44(1):122-32.
2005: Markus Galanski; Susanna Slaby; Michael A Jakupec; Bernhard K Keppler
Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine)platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand.
Bioinorganic chemistry and applications 2005;():179-90.
2005: Markus Galanski; Michael A Jakupec; Bernhard K Keppler
Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches.
Current medicinal chemistry 2005;12(18):2075-94.
2005: Michael A Jakupec; P Unfried; Bernhard K Keppler
Pharmacological properties of cerium compounds.
Reviews of physiology, biochemistry and pharmacology 2005;153():101-11.
2005: Petra Heffeter; Martina Pongratz; Elisabeth Steiner; Peter Chiba; Michael A Jakupec; Leonilla Elbling; Brigitte Marian; Wilfried Körner; F Sevelda; Michael Micksche; Bernhard K Keppler; Walter Berger
Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A).
The Journal of pharmacology and experimental therapeutics 2005;312(1):281-9.
2004: Ulrich Warnke; Christina Rappel; Heiko Meier; Charlotte Kloft; Markus Galanski; Christian G. Hartinger; Bernhard K Keppler; Ulrich Jaehde
Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation.
Chembiochem : a European journal of chemical biology 2004;5(11):1543-9.
2004: Erwin Reisner; Vladimir B Arion; M Fátima C Guedes da Silva; Roman Lichtenecker; Anna Eichinger; Bernhard K Keppler; Vadim Yu Kukushkin; Armando J L Pombeiro
Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole.
Inorganic chemistry 2004;43(22):7083-93.
2004: Markus Galanski; Afshin Yasemi; Susanna Slaby; Michael A Jakupec; Vladimir B Arion; Monika Rausch; Alexey A Nazarov; Bernhard K Keppler
Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible.
European journal of medicinal chemistry 2004;39(8):707-14.
2004: Andrei R Timerbaev; Svetlana S Aleksenko; Kasia Polec-Pawlak; Rafal Ruzik; Olga Semenova; Christian G. Hartinger; Slawomir Oszwaldowski; Markus Galanski; Katarzyna (Kasia) Pawlak; Bernhard K Keppler
Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin.
Electrophoresis 2004;25(13):1988-95.
2004: Michael A Jakupec; Bernhard K Keppler
Gallium in cancer treatment.
Current topics in medicinal chemistry 2004;4(15):1575-83.
2004: Michael A Jakupec; Bernhard K Keppler
Gallium and other main group metal compounds as antitumor agents.
Metal ions in biological systems 2004;42():425-62.
2004: Michael A Jakupec; Markus Galanski; Bernhard K Keppler
The effect of cytoprotective agents in platinum anticancer therapy.
Metal ions in biological systems 2004;42():179-208.
2003: Markus Galanski; Susanna Slaby; Michael A Jakupec; Bernhard K Keppler
Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand.
Journal of medicinal chemistry 2003;46(23):4946-51.
2003: Vladimir B Arion; Erwin Reisner; Madeleine Fremuth; Michael A Jakupec; Bernhard K Keppler; Vadim Yu Kukushkin; Armando J L Pombeiro
Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes.
Inorganic chemistry 2003;42(19):6024-31.
2003: Christian G. Hartinger; Petra Schluga; Markus Galanski; Christian Baumgartner; Andrei R Timerbaev; Bernhard K Keppler
Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry.
Electrophoresis 2003;24(12-13):2038-44.
2003: Christian G. Hartinger; Andrei R Timerbaev; Bernhard K Keppler
Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges.
Electrophoresis 2003;24(12-13):2023-37.
2003: Anastassiya V Makarycheva-Mikhailova; Vadim Yu Kukushkin; Alexey A Nazarov; Dmitrii A Garnovskii; Armando J L Pombeiro; Matti Haukka; Bernhard K Keppler; Markus Galanski
Amidines derived from Pt(IV)-mediated nitrile-amino alcohol coupling and their Zn(II)-catalyzed conversion into oxazolines.
Inorganic chemistry 2003;42(8):2805-13.
2003: M Galanski; Vladimir B Arion; Michael A Jakupec; Bernhard K Keppler
Recent developments in the field of tumor-inhibiting metal complexes.
Current pharmaceutical design 2003;9(25):2078-89.
2003: Michael A Jakupec; Markus Galanski; Bernhard K Keppler
Tumour-inhibiting platinum complexes--state of the art and future perspectives.
Reviews of physiology, biochemistry and pharmacology 2003;146():1-54.
2002: Vladimir B Arion; Michael A Jakupec; Markus Galanski; Peter Unfried; Bernhard K Keppler
Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone.
Journal of inorganic biochemistry 2002;91(1):298-305.
2002: Andrei R Timerbaev; Angelika Küng; Bernhard K Keppler
Capillary electrophoresis of platinum-group elements. Analytical, speciation and biochemical studies.
Journal of chromatography. A 2002;945(1-2):25-44.
2002: Dirk B Strickmann; Angelika Kong; Bernhard K Keppler
Application of capillary electrophoresis-mass spectrometry for the investigation of the binding behavior of oxaliplatin to 5'-GMP in the presence of the sulfur-containing amino acid L-methionine.
Electrophoresis 2002;23(1):74-80.
2001: Angelika Küng; D B Strickmann; Markus Galanski; Bernhard K Keppler
Comparison of the binding behavior of oxaliplatin, cisplatin and analogues to 5'-GMP in the presence of sulfur-containing molecules by means of capillary electrophoresis and electrospray mass spectrometry.
Journal of inorganic biochemistry 2001;86(4):691-8.
2001: Angelika Küng; T Pieper; Bernhard K Keppler
Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):81-9.
2001: Stephan Hann; A Zenker; Markus Galanski; Thomas L Bereuter; Gerhard Stingeder; Bernhard K Keppler
HPIC-UV-ICP-SFMS study of the interaction of cisplatin with guanosine monophosphate.
Fresenius' journal of analytical chemistry 2001;370(5):581-6.
2001: Peter Zöllner; A Zenker; Markus Galanski; Bernhard K Keppler; Wolfgang Lindner
Reaction monitoring of platinum(II) complex--5'-guanosine monophosphate adduct formation by ion exchange liquid chromatography/electrospray ionization mass spectrometry.
Journal of mass spectrometry : JMS 2001;36(7):742-53.
2001: Angelika Küng; T Pieper; R Wissiack; E Rosenberg; Bernhard K Keppler
Hydrolysis of the tumor-inhibiting ruthenium(III) complexes HIm trans-[RuCl4(im)2] and HInd trans-[RuCl4(ind)2] investigated by means of HPCE and HPLC-MS.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(3):292-9.
2001: Angelika Küng; A Zenker; Markus Galanski; Bernhard K Keppler
Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides.
Journal of inorganic biochemistry 2001;83(2-3):181-6.
2000: A Zenker; Markus Galanski; Thomas L Bereuter; Bernhard K Keppler; Wolfgang Lindner
Kinetics of binding properties of 5'-GMP with cisplatin under simulated physiological conditions by capillary electrophoresis.
Journal of chromatography. B, Biomedical sciences and applications 2000;745(1):211-9.
2000: A Zenker; Markus Galanski; Thomas L Bereuter; Bernhard K Keppler; Wolfgang Lindner
Time-dependent interactions of platinum(II) complexes with 5'-GMP under simulated physiological conditions studies by capillary electrophoresis.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(4):498-504.
2000: Markus Galanski; M Berger; Bernhard K Keppler
Synthesis of (N,N'-Bis(2-Hydroxyethyl)Ethane-1,2-Diamine)Malonatoplatinum(II) and X-Ray Crystal Structure of the Cis-R,S-Isomer.
Metal-based drugs 2000;7(6):349-55.
2000: T Pieper; Wolfgang Peti; Bernhard K Keppler
Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III).
Metal-based drugs 2000;7(4):225-32.
1999: A Zenker; Markus Galanski; Thomas L Bereuter; Bernhard K Keppler; Wolfgang Lindner
Capillary electrophoretic study of cisplatin interaction with nucleoside monophosphates, di- and trinucleotides.
Journal of chromatography. A 1999;852(1):337-46.
1996: K G Lipponer; E Vogel; Bernhard K Keppler
Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliumtetrachlorobis-(1-Methylindazole)Ruthenate(III) and its Hydrolysis Product trans-Monoaquatrichlorobis-(1-Methylindazole)-Ruthenate(III).
Metal-based drugs 1996;3(5):243-60.