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Oliver Keppler

Research Profile

Living Beings

Chemicals & Drugs

Physiology

Disorders

HIV Infections

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Virus Internalization

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Publications

TOP 3
Hanna-Mari Baldauf; Manja Burggraf; Waaqo Daddacha; Elina Erikson; Oliver T Fackler; Egbert Flory; Thomas Gramberg; Baek Kim; Renate König; Nathaniel R Landau; Felix Lasitschka; Xiaoyu Pan; Sylvia Panitz; Frank Rutsch; Kristina Schenkova; Sarah Schmidt; Serkan Sertel; Guido Wabnitz; Ina Ambiel; Oliver T Keppler
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Newton Wahome; Yongkun Yang; Ina Ambiel; Valerie Bosch; Oliver T Keppler; Tanya Pfeiffer; Peter Burkhard
Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine.
Sibylle Haid; Thierry Hennebelle; Céline Hernandez; Beate Jannack; Oliver T Keppler; Matthieu Lemasson; Alexandra Novodomská; François Bailleul; Dorothea Bankwitz; Ralf Bartenschlager; Patrick Chhatwal; Elisabeth Davioud; Juliane Gentzsch; Silvia Geuenich; Christina Grethe; Marion Poenisch; Arielle R Rosenberg; Flossie Wong-Staal; Thomas Pietschmann
A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.

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All Publications

2012: Hanna-Mari Baldauf; Manja Burggraf; Waaqo Daddacha; Elina Erikson; Oliver T Fackler; Egbert Flory; Thomas Gramberg; Baek Kim; Renate König; Nathaniel R Landau; Felix Lasitschka; Xiaoyu Pan; Sylvia Panitz; Frank Rutsch; Kristina Schenkova; Sarah Schmidt; Serkan Sertel; Guido Wabnitz; Ina Ambiel; Oliver T Keppler
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine 2012;18(11):1682-7.
2012: Newton Wahome; Yongkun Yang; Ina Ambiel; Valerie Bosch; Oliver T Keppler; Tanya Pfeiffer; Peter Burkhard
Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine.
Chemical biology & drug design 2012;80(3):349-57.
2012: Sibylle Haid; Thierry Hennebelle; Céline Hernandez; Beate Jannack; Oliver T Keppler; Matthieu Lemasson; Alexandra Novodomská; François Bailleul; Dorothea Bankwitz; Ralf Bartenschlager; Patrick Chhatwal; Elisabeth Davioud; Juliane Gentzsch; Silvia Geuenich; Christina Grethe; Marion Poenisch; Arielle R Rosenberg; Flossie Wong-Staal; Thomas Pietschmann
A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.
Gastroenterology 2012;143(1):213-22.e5.
2012: Joëlle V Fritz; Oliver T Keppler; Nadine Tibroni; Oliver T Fackler
HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.
Virology 2012;424(1):33-44.
2012: Katja Sliva; Christine Goffinet; Oliver T Keppler; Benjamin Kraus; Theresa Resch; Barbara S Schnierle
The cellular antiviral restriction factor tetherin does not inhibit poxviral replication.
Journal of virology 2012;86(3):1893-6.
2011: Elina Erikson; Christine Goffinet; Christoph Harter; Felix Lasitschka; Judith Lehmann-Koch; Benjamin Over; Sarah Schmidt; Serkan Sertel; Tarek Adam; Isabelle Bekeredjian-Ding; Oliver T Keppler
In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13688-93.
2011: Sonja Welsch; Fedde Groot; Oliver T Keppler; Hans-Georg Kräusslich; Quentin J Sattentau
Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages.
Journal of virology 2011;85(15):7922-7.
2011: Sarah Schmidt; Joëlle V Fritz; Julia Bitzegeio; Oliver T Fackler; Oliver T Keppler
HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction.
mBio 2011;2(3):e00036-11.
2011: Hanna-Mari Tervo; Stefanie Homann; Ina Ambiel; Joëlle V Fritz; Oliver T Fackler; Oliver T Keppler
β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.
Retrovirology 2011;8():9.
2010: Hanna-Mari Tervo; Oliver T Keppler
High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.
Journal of virology 2010;84(23):12300-14.
2010: Christine Goffinet; Sarah Schmidt; Christian Kern; Lena Oberbremer; Oliver T Keppler
Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.
Journal of virology 2010;84(21):11374-84.
2010: Christine Goffinet; Stefanie Homann; Ina Ambiel; Nadine Tibroni; Daniel Rupp; Oliver T Keppler; Oliver T Fackler
Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.
Journal of virology 2010;84(8):4089-94.
2010: Daniel Rupp; Silvia Geuenich; Oliver T Keppler
Poor performance of bioinformatics programs for genotypic prediction of coreceptor usage of HIV-1 group O isolates.
Journal of acquired immune deficiency syndromes (1999) 2010;53(3):412-3.
2009: Barbara Müller; Maria Anders; Hisashi Akiyama; Sonja Welsch; Bärbel Glass; Krisztina Nikovics; Francois Clavel; Hanna-Mari Tervo; Oliver T Keppler; Hans-Georg Kräusslich
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.
The Journal of biological chemistry 2009;284(43):29692-703.
2009: Silvia Geuenich; Lars Kaderali; Ina Allespach; Serkan Sertel; Oliver T Keppler
Biological signature characteristics of primary isolates from human immunodeficiency virus type 1 group O in ex vivo human tonsil histocultures.
Journal of virology 2009;83(20):10494-503.
2009: Christine Goffinet; Ina Allespach; Lena Oberbremer; Pamela L Golden; Scott A Foster; Brian A Johns; Jason G Weatherhead; Steven J Novick; Karen E Chiswell; Edward P Garvey; Oliver T Keppler
Pharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivo.
Journal of virology 2009;83(15):7706-17.
2009: Christine Goffinet; Ina Allespach; Stefanie Homann; Hanna-Mari Tervo; Anja Habermann; Daniel Rupp; Lena Oberbremer; Christian Kern; Nadine Tibroni; Sonja Welsch; Jacomine Krijnse-Locker; George Banting; Hans-Georg Kräusslich; Oliver T Fackler; Oliver T Keppler
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.
Cell host & microbe 2009;5(3):285-97.
2009: Stefanie Homann; Nadine Tibroni; Ingo Baumann; Serkan Sertel; Oliver T Keppler; Oliver T Fackler
Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo.
Retrovirology 2009;6():6.
2009: Nico Michel; Christine Goffinet; Kerstin Ganter; Ina Allespach; Vineet N KewalRamani; Mohammed Saifuddin; Dan R Littman; Warner Greene; Mark A Goldsmith; Oliver T Keppler
Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.
Retrovirology 2009;6():2.
2008: Hanna-Mari Tervo; Ina Allespach; Oliver T Keppler
High-level transfection of primary rabbit T lymphocytes.
Journal of immunological methods 2008;336(1):85-9.
2008: Hanna-Mari Tervo; Christine Goffinet; Oliver T Keppler
Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.
Retrovirology 2008;5():58.
2008: Silvia Geuenich; Christine Goffinet; Stephanie Venzke; Silke Nolkemper; Ingo Baumann; Peter Plinkert; Jürgen Reichling; Oliver T Keppler
Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.
Retrovirology 2008;5():27.
2007: Jan Münch; Elke Rücker; Ludger Ständker; Knut Adermann; Christine Goffinet; Michael Schindler; Steffen Wildum; Raghavan Chinnadurai; Devi Rajan; Anke Specht; Guillermo Giménez-Gallego; Pedro Cuevas Sánchez; Fowler Douglas; Atanas Koulov; Jeffery W Kelly; Walther Mothes; Jean-Charles Grivel; Leonid Margolis; Oliver T Keppler; Wolf-Georg Forssmann; Frank Kirchhoff
Semen-derived amyloid fibrils drastically enhance HIV infection.
Cell 2007;131(6):1059-71.
2007: Sonja Welsch; Oliver T Keppler; Anja Habermann; Ina Allespach; Jacomine Krijnse-Locker; Hans-Georg Kräusslich
HIV-1 buds predominantly at the plasma membrane of primary human macrophages.
PLoS pathogens 2007;3(3):e36.
2007: Christine Goffinet; Ina Allespach; Oliver T Keppler
HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):1015-20.
2007: Christine Goffinet; Nico Michel; Ina Allespach; Hanna-Mari Tervo; Volker Hermann; Hans-Georg Kräusslich; Warner Greene; Oliver T Keppler
Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.
Retrovirology 2007;4():53.
2006: Stephanie Venzke; Nico Michel; Ina Allespach; Oliver T Fackler; Oliver T Keppler
Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.
Journal of virology 2006;80(22):11141-52.
2006: Nico Michel; Kerstin Ganter; Stephanie Venzke; Julia Bitzegeio; Oliver T Fackler; Oliver T Keppler
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.
Molecular biology of the cell 2006;17(8):3578-90.
2006: Claudia Haller; Susanne Rauch; Nico Michel; Sebastian Hannemann; Maik J Lehmann; Oliver T Keppler; Oliver T Fackler
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.
The Journal of biological chemistry 2006;281(28):19618-30.
2006: Stephanie Venzke; Oliver T Keppler
Role of macrophages in HIV infection and persistence.
Expert review of clinical immunology 2006;2(4):613-26.
2006: Christine Goffinet; Oliver T Keppler
Efficient nonviral gene delivery into primary lymphocytes from rats and mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):500-2.
2006: Oliver T Keppler; Nadine Tibroni; Stephanie Venzke; Susanne Rauch; Oliver T Fackler
Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.
Journal of leukocyte biology 2006;79(3):616-27.
2005: Nico Michel; Ina Allespach; Stephanie Venzke; Oliver T Fackler; Oliver T Keppler
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.
Current biology : CB 2005;15(8):714-23.
2005: Oliver T Keppler; Ina Allespach; Lismarie Schüller; David Fenard; Warner Greene; Oliver T Fackler
Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef.
Journal of virology 2005;79(3):1655-65.
2004: Denis M Tebit; Leopold Zekeng; Lazare Kaptué; Lutz Gürtler; Oliver T Fackler; Oliver T Keppler; Ottmar Herchenröder; Hans-Georg Kräusslich
Construction and characterization of an HIV-1 group O infectious molecular clone and analysis of vpr- and nef-negative derivatives.
Virology 2004;326(2):329-39.