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Earl Kern

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Physiology

Virus Replication

Procedures

Plaque Assay

Disorders

Cytomegalovirus Infections

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Co-Publications
Name
26
Hartline, Caroll
24
Drach, John
24
Zemlicka, Jiri
22
Prichard, Mark
20
Keith, Kathy
20
Quenelle, Debra
19
Hostetler, Karl
18
Beadle, James
13
Cheng, Yung-Chi
12
Harden, Emma
11
Bidanset, Deborah
9
Collins, Deborah
9
Rybak, Rachel
9
Wan, William
8
Gullen, Elizabeth

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Publications

TOP 3
Harden Emma A; Falshaw Ruth; Carnachan Susan M; Kern Earl R; Prichard Mark N
Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus.
Kern Earl R; Prichard Mark N; Quenelle Debra C; Keith Kathy A; Tiwari Kamal N; Maddry Joseph A; Secrist John A
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Prichard Mark N; Hartline Caroll B; Harden Emma A; Daily Shannon L; Beadle James R; Valiaeva Nadejda; Kern Earl R; Hostetler Karl Y
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

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All Publications

2009: Harden Emma A; Falshaw Ruth; Carnachan Susan M; Kern Earl R; Prichard Mark N
Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus.
Antiviral research 2009;83(3):282-9.
2009: Kern Earl R; Prichard Mark N; Quenelle Debra C; Keith Kathy A; Tiwari Kamal N; Maddry Joseph A; Secrist John A
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Antimicrobial agents and chemotherapy 2009;53(2):572-9.
2008: Prichard Mark N; Hartline Caroll B; Harden Emma A; Daily Shannon L; Beadle James R; Valiaeva Nadejda; Kern Earl R; Hostetler Karl Y
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2008;52(12):4326-30.
2008: Quenelle Debra C; Collins Deborah J; Rice Terri L; Prichard Mark N; Marciani Dante J; Kern Earl R
Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs.
Antiviral research 2008;80(2):223-4.
2008: Quenelle Debra C; Collins Deborah J; Pettway Latisha R; Hartline Caroll B; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Antiviral research 2008;79(2):133-5.
2008: Prichard Mark N; Sztul Elizabeth; Daily Shannon L; Perry Amie L; Frederick Samuel L; Gill Rachel B; Hartline Caroll B; Streblow Daniel N; Varnum Susan M; Smith Richard D; Kern Earl R
Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.
Journal of virology 2008;82(10):5054-67.
2008: Becker Marie N; Obraztsova Maria; Kern Earl R; Quenelle Debra C; Keith Kathy A; Prichard Mark N; Luo Ming; Moyer Richard W
Isolation and characterization of cidofovir resistant vaccinia viruses.
Virology journal 2008;5():58.
2008: Prichard Mark N; Kern Earl R; Quenelle Debra C; Keith Kathy A; Moyer Richard W; Turner Peter C
Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.
Virology journal 2008;5():39.
2007: Quenelle Debra C; Collins Deborah J; Herrod Bridgett P; Keith Kathy A; Trahan Julissa; Beadle James R; Hostetler Karl Y; Kern Earl R
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Antimicrobial agents and chemotherapy 2007;51(11):3940-7.
2007: Quenelle Debra C; Prichard Mark N; Keith Kathy A; Hruby Dennis E; Jordan Robert; Painter George R; Robertson Alice; Kern Earl R
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.
Antimicrobial agents and chemotherapy 2007;51(11):4118-24.
2007: Prichard Mark N; Daily Shannon L; Jefferson Geraldine M; Perry Amie L; Kern Earl R
A rapid DNA hybridization assay for the evaluation of antiviral compounds against Epstein-Barr virus.
Journal of virological methods 2007;144(1-2):86-90.
2007: Ruiz Jacqueline C; Beadle James R; Aldern Kathy A; Keith Kathy A; Hartline Caroll B; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Antiviral research 2007;75(1):87-90.
2007: Prichard Mark N; Keith Kathy A; Johnson Mary P; Harden Emma A; McBrayer Alexis; Luo Ming; Qiu Shihong; Chattopadhyay Debasish; Fan Xuesen; Torrence Paul F; Kern Earl R
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Antimicrobial agents and chemotherapy 2007;51(5):1795-803.
2007: Choo Hyunah; Beadle James R; Kern Earl R; Prichard Mark N; Keith Kathy A; Hartline Caroll B; Trahan Julissa; Aldern Kathy A; Korba Brent E; Hostetler Karl Y
Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
Antimicrobial agents and chemotherapy 2007;51(2):611-5.
2007: Quenelle Debra C; Buller R M L; Parker Scott; Keith Kathy A; Hruby Dennis E; Jordan Robert; Kern Earl R
Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.
Antimicrobial agents and chemotherapy 2007;51(2):689-95.
2007: Zhou Shaoman; Zemlicka Jiri; Kern Earl R; Drach John C
Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.
Nucleosides, nucleotides & nucleic acids 2007;26(3):231-43.
2006: Zhou Shaoman; Kern Earl R; Gullen Elizabeth; Cheng Yung-Chi; Drach John C; Tamiya Sadahiro; Mitsuya Hiroaki; Zemlicka Jiri
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Journal of medicinal chemistry 2006;49(20):6120-8.
2006: Kern Earl R
Pivotal role of animal models in the development of new therapies for cytomegalovirus infections.
Antiviral research 2006;71(2-3):164-71.
2006: Fan Xuesen; Zhang Xinying; Zhou Longhu; Keith Kathy A; Kern Earl R; Torrence Paul F
Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.
Antiviral research 2006;71(2-3):201-5.
2006: Quenelle Debra C; Keith Kathy A; Kern Earl R
In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections.
Antiviral research 2006;71(1):24-30.
2006: Prichard Mark N; Williams Angela D; Keith Kathy A; Harden Emma A; Kern Earl R
Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.
Antiviral research 2006;71(1):1-6.
2006: Fan Xuesen; Zhang Xinying; Zhou Longhu; Keith Kathy A; Prichard Mark N; Kern Earl R; Torrence Paul F
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
Journal of medicinal chemistry 2006;49(14):4052-4.
2006: Fan Xuesen; Zhang Xinying; Zhou Longhu; Keith Kathy A; Kern Earl R; Torrence Paul F
5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.
Journal of medicinal chemistry 2006;49(11):3377-82.
2006: Fan Xuesen; Zhang Xinying; Zhou Longhu; Keith Kathy A; Kern Earl R; Torrence Paul F
A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.
Bioorganic & medicinal chemistry letters 2006;16(12):3224-8.
2006: Prichard Mark N; Keith Kathy A; Quenelle Debra C; Kern Earl R
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Antimicrobial agents and chemotherapy 2006;50(4):1336-41.
2006: Beadle James R; Wan William B; Ciesla Stephanie L; Keith Kathy A; Hartline Caroll; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Journal of medicinal chemistry 2006;49(6):2010-5.
2006: Quenelle Debra C; Collins Deborah J; Marciani Dante J; Kern Earl R
Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2.
Vaccine 2006;24(10):1515-22.
2006: Parker Jacqueline N; Pfister Luz-Andrea; Quenelle Debra; Gillespie G Yancey; Markert James M; Kern Earl R; Whitley Richard J
Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates.
Vaccine 2006;24(10):1644-52.
2006: Qin Xinrong; Chen Xinchao; Wang Kun; Polin Lisa; Kern Earl R; Drach John C; Gullen Elizabeth; Cheng Yung-Chi; Zemlicka Jiri
Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.
Bioorganic & medicinal chemistry 2006;14(4):1247-54.
2006: Ruiz Jacqueline C; Aldern Kathy A; Beadle James R; Hartline Caroll B; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.
Antiviral chemistry & chemotherapy 2006;17(2):89-95.
2006: Prichard Mark N; Quenelle Debra C; Bidanset Deborah J; Komazin Gloria; Chou Sunwen; Drach John C; Kern Earl R
Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice.
Virology journal 2006;3():18.
2005: Prichard Mark N; Britt William J; Daily Shannon L; Hartline Caroll B; Kern Earl R
Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis.
Journal of virology 2005;79(24):15494-502.
2005: Prichard Mark N; Kaiwar Ravi; Jackman Winthrop T; Quenelle Debra C; Collins Deborah J; Kern Earl R; Kemble George M; Spaete Richard R
Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs.
Vaccine 2005;23(46-47):5424-31.
2005: Williams-Aziz Stephanie L; Hartline Caroll B; Harden Emma A; Daily Shannon L; Prichard Mark N; Kushner Nicole L; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.
Antimicrobial agents and chemotherapy 2005;49(9):3724-33.
2005: Kriesel John D; Spruance Spotswood L; Prichard Mark; Parker Jacqueline N; Kern Earl R
Recurrent antiviral-resistant genital herpes in an immunocompetent patient.
The Journal of infectious diseases 2005;192(1):156-61.
2005: Roy Atanu; Schneller Stewart W; Keith Kathy A; Hartline Caroll B; Kern Earl R
The 4',4'-difluoro analog of 5'-noraristeromycin: a new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus.
Bioorganic & medicinal chemistry 2005;13(14):4443-9.
2005: Prichard Mark N; Kern Earl R
Orthopoxvirus targets for the development of antiviral therapies.
Current drug targets. Infectious disorders 2005;5(1):17-28.
2005: Kern Earl R; Kushner Nicole L; Hartline Caroll B; Williams-Aziz Stephanie L; Harden Emma A; Zhou Shaoman; Zemlicka Jiri; Prichard Mark N
In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication.
Antimicrobial agents and chemotherapy 2005;49(3):1039-45.
2005: Hartline Caroll B; Harden Emma A; Williams-Aziz Stephanie L; Kushner Nicole L; Brideau Roger J; Kern Earl R
Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity.
Antiviral research 2005;65(2):97-105.
2005: Wan William B; Beadle James R; Hartline Caroll; Kern Earl R; Ciesla Stephanie L; Valiaeva Nadejda; Hostetler Karl Y
Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.
Antimicrobial agents and chemotherapy 2005;49(2):656-62.
2005: Hartline Caroll B; Gustin Kortney M; Wan William B; Ciesla Stephanie L; Beadle James R; Hostetler Karl Y; Kern Earl R
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
The Journal of infectious diseases 2005;191(3):396-9.
2005: Yan Zhaohua; Kern Earl R; Gullen Elizabeth; Cheng Yung-Chi; Drach John C; Zemlicka Jiri
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
Journal of medicinal chemistry 2005;48(1):91-9.
2005: Ambrose Amalraj; Zemlicka Jiri; Kern Earl R; Drach John C; Gullen Elizabeth; Cheng Yung-Chi
Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1763-74.
2005: Zhou Longhu; Amer Adel; Korn Michael; Burda Robert; Balzarini Jan; De Clercq Erik; Kern Earl R; Torrence Paul F
Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation.
Antiviral chemistry & chemotherapy 2005;16(6):375-83.
2005: Prichard Mark N; Lawlor Heather; Duke Gregory M; Mo Chengjun; Wang Zhaoti; Dixon Melissa; Kemble George; Kern Earl R
Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.
Virology journal 2005;2():55.
2004: Zhou Shaoman; Kern Earl R; Gullen Elizabeth; Cheng Yung-Chi; Drach John C; Matsumi Shintaro; Mitsuya Hiroaki; Zemlicka Jiri
(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
Journal of medicinal chemistry 2004;47(27):6964-72.
2004: Kern Earl R; Bidanset Deborah J; Hartline Caroll B; Yan Zhaohua; Zemlicka Jiri; Quenelle Debra C
Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections.
Antimicrobial agents and chemotherapy 2004;48(12):4745-53.
2004: Kern Earl R; Collins Deborah J; Wan W Brad; Beadle James R; Hostetler Karl Y; Quenelle Debra C
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.
Antimicrobial agents and chemotherapy 2004;48(9):3516-22.
2004: Bidanset Deborah J; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.
The Journal of infectious diseases 2004;190(3):499-503.
2004: Bidanset Deborah J; Rybak Rachel J; Hartline Caroll B; Kern Earl R
Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue.
Antiviral research 2004;63(1):61-4.
2004: Quenelle Debra C; Collins Deborah J; Kern Earl R
Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir.
Antiviral research 2004;63(1):33-40.
2004: Keith Kathy A; Wan William B; Ciesla Stephanie L; Beadle James R; Hostetler Karl Y; Kern Earl R
Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
Antimicrobial agents and chemotherapy 2004;48(5):1869-71.
2004: Kern Earl R; Hartline Caroll B; Rybak Rachel J; Drach John C; Townsend Leroy B; Biron Karen K; Bidanset Deborah J
Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.
Antimicrobial agents and chemotherapy 2004;48(5):1749-55.
2004: Quenelle Debra C; Collins Deborah J; Wan W Brad; Beadle James R; Hostetler Karl Y; Kern Earl R
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.
Antimicrobial agents and chemotherapy 2004;48(2):404-12.
2004: Zhou Shaoman; Breitenbach Julie M; Borysko Katherine Z; Drach John C; Kern Earl R; Gullen Elizabeth; Cheng Yung-Chi; Zemlicka Jiri
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
Journal of medicinal chemistry 2004;47(3):566-75.
2003: Kushner Nicole L; Williams Stephanie L; Hartline Caroll B; Harden Emma A; Bidanset Deborah J; Chen Xinchao; Zemlicka Jiri; Kern Earl R
Efficacy of methylenecyclopropane analogs of nucleosides against herpesvirus replication in vitro.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2105-19.
2003: Quenelle Debra C; Collins Deborah J; Kern Earl R
Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice.
Antimicrobial agents and chemotherapy 2003;47(10):3275-80.
2003: Keith Kathy A; Hitchcock Michael J M; Lee William A; Holý Antonin; Kern Earl R
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Antimicrobial agents and chemotherapy 2003;47(7):2193-8.
2003: Williams Stephanie L; Hartline Caroll B; Kushner Nicole L; Harden Emma A; Bidanset Deborah J; Drach John C; Townsend Leroy B; Underwood Mark R; Biron Karen K; Kern Earl R
In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.
Antimicrobial agents and chemotherapy 2003;47(7):2186-92.
2003: Wang Ruifang; Chen Xinchao; Drach John C; Kern Earl R; Zemlicka Jiri
Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):813-5.
2003: Temperton Nigel J; Quenelle Debra C; Lawson Keirissa M; Zuckerman Jane N; Kern Earl R; Griffiths Paul D; Emery Vincent C
Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides.
Journal of medical virology 2003;70(1):86-90.
2003: Long Mary C; Bidanset Deborah J; Williams Stephanie L; Kushner Nicole L; Kern Earl R
Determination of antiviral efficacy against lymphotropic herpesviruses utilizing flow cytometry.
Antiviral research 2003;58(2):149-57.
2003: Chen Xinchao; Kern Earl R; Drach John C; Gullen Elizabeth; Cheng Yung-Chi; Zemlicka Jiri
Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus.
Journal of medicinal chemistry 2003;46(8):1531-7.
2003: Wang Ruifang; Chen Xinchao; Drach John C; Kern Earl R; Zemlicka Jiri
Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(2):135-44.
2003: Kern Earl R
In vitro activity of potential anti-poxvirus agents.
Antiviral research 2003;57(1-2):35-40.
2002: Wang Ruifang; Corbett Thomas H; Cheng Yung-Chi; Drach John C; Kern Earl R; Mitsuya Hiroaki; Zemlicka Jiri
Tryptophanyl phosphoramidates as prodrugs of synadenol and its E-isomer: synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2002;12(17):2467-70.
2002: Beadle James R; Hartline Caroll; Aldern Kathy A; Rodriguez Natalie; Harden Emma; Kern Earl R; Hostetler Karl Y
Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.
Antimicrobial agents and chemotherapy 2002;46(8):2381-6.
2002: Wang Ruifang; Kern Earl R; Zemlicka Jiri
Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: a new pronucleotide effective against Epstein-Barr virus.
Antiviral chemistry & chemotherapy 2002;13(4):251-62.
2002: Kern Earl R; Hartline Caroll; Harden Emma; Keith Kathy; Rodriguez Natalie; Beadle James R; Hostetler Karl Y
Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
Antimicrobial agents and chemotherapy 2002;46(4):991-5.
2002: Rajappan Vasanthakumar; Schneller Stewart W; Williams Stephanie L; Kern Earl R
The enantiomers of carbocyclic 5'-norguanosine: activity towards Epstein-Barr virus.
Bioorganic & medicinal chemistry 2002;10(4):883-6.
2001: Wang R; Ksebati M B; Corbett T H; Kern E R; Drach J C; Zemlicka J
Methylene-gem-difluorocyclopropane analogues of nucleosides: synthesis, cyclopropene-methylenecyclopropane rearrangement, and biological activity.
Journal of medicinal chemistry 2001;44(23):4019-22.
2001: Bidanset D J; Placidi L; Rybak R; Palmer J; Sommadossi J P; Kern E R
Intravenous infusion of cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains.
Antimicrobial agents and chemotherapy 2001;45(8):2316-23.
2001: Bidanset D J; Rybak R J; Hartline C B; Kern E R
Replication of human cytomegalovirus in severe combined immunodeficient mice implanted with human retinal tissue.
The Journal of infectious diseases 2001;184(2):192-5.
2001: Hostetler K Y; Rybak R J; Beadle J R; Gardner M F; Aldern K A; Wright K N; Kern E R
In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.
Antiviral chemistry & chemotherapy 2001;12(1):61-70.
2001: Kern E R; Rybak R J; Hartline C B; Bidanset D J
Predictive efficacy of SCID-hu mouse models for treatment of human cytomegalovirus infections.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():149-56.
2000: Guan H P; Ksebati M B; Kern E R; Zemlicka J
Approaches to unsaturated analogues of nucleosides comprising four- and six-membered rings.
The Journal of organic chemistry 2000;65(17):5177-84.
2000: Rybak R J; Hartline C B; Qiu Y L; Zemlicka J; Harden E; Marshall G; Sommadossi J P; Kern E R
In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections.
Antimicrobial agents and chemotherapy 2000;44(6):1506-11.
2000: Qiu Y L; Geiser F; Kira T; Gullen E; Cheng Y C; Ptak R G; Breitenbach J M; Drach J C; Hartline C B; Kern E R; Zemlicka J
Synthesis and enantioselectivity of the antiviral effects of (R,Z)-,(S,Z)-methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: influence of heterocyclic base, type of virus and host cells.
Antiviral chemistry & chemotherapy 2000;11(3):191-202.
2000: Guan H P; Ksebati M B; Cheng Y C; Drach J C; Kern E R; Zemlicka J
Spiropentane mimics of nucleosides: analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, isomeric assignment, and biological activity.
The Journal of organic chemistry 2000;65(5):1280-90.
2000: Kern E R; Palmer J; Szczech G; Painter G; Hostetler K Y
Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):501-13.
2000: Beadle J R; Kini G D; Aldern K A; Gardner M F; Wright K N; Rybak R J; Kern E R; Hostetler K Y
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):471-9.
1999: Rybak R J; Zemlicka J; Qiu Y L; Hartline C B; Kern E R
Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.
Antiviral research 1999;43(3):175-88.
1999: Qiu Y L; Ptak R G; Breitenbach J M; Lin J S; Cheng Y C; Drach J C; Kern E R; Zemlicka J
Synthesis and antiviral activity of phosphoralaninate derivatives of methylenecyclopropane analogues of nucleosides.
Antiviral research 1999;43(1):37-53.
1999: Afouna M I; Mehta S C; Ghanem A H; Higuchi W I; Kern E R; DeClercq E; El-Shattawy H H
Influence of the treatment protocol upon the in vivo efficacy of cidofovir (HPMPC) and of acyclovir (ACV) formulations in topical treatment of cutaneous HSV-1 infection in hairless mice.
Journal of pharmaceutical sciences 1999;88(5):530-4.
1998: Afouna M I; Mehta S C; Ghanem A H; Higuchi W I; Kern E R; De Clercq E; El-Shattawy H H
Assessment of correlation between skin target site free drug concentration and the in vivo topical antiviral efficacy in hairless mice for (E)-5-(2-bromovinyl)-2'-deoxyuridine and acyclovir formulations.
Journal of pharmaceutical sciences 1998;87(8):917-21.
1998: Qiu Y L; Ptak R G; Breitenbach J M; Lin J S; Cheng Y C; Kern E R; Drach J C; Zemlicka J
(Z)- and (E)-2-(hydroxymethylcyclopropylidene)-methylpurines and pyrimidines as antiviral agents.
Antiviral chemistry & chemotherapy 1998;9(4):341-52.
1998: Spector F C; Kern E R; Palmer J; Kaiwar R; Cha T A; Brown P; Spaete R R
Evaluation of a live attenuated recombinant virus RAV 9395 as a herpes simplex virus type 2 vaccine in guinea pigs.
The Journal of infectious diseases 1998;177(5):1143-54.
1998: Qiu Y L; Ksebati M B; Ptak R G; Fan B Y; Breitenbach J M; Lin J S; Cheng Y C; Kern E R; Drach J C; Zemlicka J
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Journal of medicinal chemistry 1998;41(1):10-23.
1997: Mehta S C; Afouna M I; Ghanem A H; Higuchi W I; Kern E R
Relationship of skin target site free drug concentration (C*) to the in vivo efficacy: an extensive evaluation of the predictive value of the C* concept using acyclovir as a model drug.
Journal of pharmaceutical sciences 1997;86(7):797-801.
1996: Patel P J; Ghanem A H; Higuchi W I; Srinivasan V; Kern E R
Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: an evaluation of the predictive value of the C* concept.
Antiviral research 1996;29(2-3):279-86.
1996: Kern E R
Role of animal models in selecting antiviral combinations for clinical studies.
Antiviral research 1996;29(1):57-9.
1995: Krawczyk S H; Nassiri M R; Kucera L S; Kern E R; Ptak R G; Wotring L L; Drach J C; Townsend L B
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Journal of medicinal chemistry 1995;38(20):4106-14.
1995: Kimberlin D W; Kern E R; Sidwell R W; North T W; Whitley R J
Models of antiviral resistance.
Antiviral research 1995;26(4):415-22.
1994: Imanidis G; Song W Q; Lee P H; Su M H; Kern E R; Higuchi W I
Estimation of skin target site acyclovir concentrations following controlled (trans)dermal drug delivery in topical and systemic treatment of cutaneous HSV-1 infections in hairless mice.
Pharmaceutical research 1994;11(7):1035-41.
1993: Whitley R J; Kern E R; Chatterjee S; Chou J; Roizman B
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.
The Journal of clinical investigation 1993;91(6):2837-43.
1992: Chatterjee S; Burns P; Whitley R J; Kern E R
Effect of (S)-1-[(3-hydroxy-2-phosphonyl methoxy) propyl] cytosine on the replication and morphogenesis of herpes simplex virus type 1.
Antiviral research 1992;19(3):181-92.
1992: Lee P H; Su M H; Kern E R; Higuchi W I
Novel animal model for evaluating topical efficacy of antiviral agents: flux versus efficacy correlations in the acyclovir treatment of cutaneous herpes simplex virus type 1 (HSV-1) infections in hairless mice.
Pharmaceutical research 1992;9(8):979-89.
1992: Renau T E; Nassiri M R; Swayze E E; Kern E R; Townsend L B; Drach J C
Improved synthesis and biological evaluation of an acyclic thiosangivamycin active against human cytomegalovirus.
Antiviral research 1992;19(1):15-28.
1991: Kern E R
Value of animal models to evaluate agents with potential activity against human cytomegalovirus.
Transplantation proceedings 1991;23(3 Suppl 3):152-5, discussion 155.
1991: Shao Y L; Shelby J; Hisatake G; Kern E R; Nelson E W; Gay W A
Accelerated cardiac allograft rejection in murine cytomegalovirus-infected C3H recipients.
Transplantation proceedings 1991;23(1 Pt 1):129-30.
1990: Krawczyk S H; Bernier-Rodriguez M; Nassiri M R; Kern E R; Wotring L L; Drach J C; Townsend L B
Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections.
Journal of medicinal chemistry 1990;33(12):3160-9.
1990: Pudlo J S; Nassiri M R; Kern E R; Wotring L L; Drach J C; Townsend L B
Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Journal of medicinal chemistry 1990;33(7):1984-92.
1989: Shelby J; Saffle J R; Kern E R
Delayed type hypersensitivity (DTH) response and skin graft survival in 9-(1, 3-dihydroxy-2-propoxymethyl) guanine (DHPG) treated mice.
Transplantation proceedings 1989;21(1 Pt 1):1150-1.

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