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Scott Kern

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Chemicals & Drugs

Genes & Molecular Sequences

Physiology

Anatomy

Cultured Tumor Cells

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Molecular Sequence Data

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Publications

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Jones Siân; Hruban Ralph H; Kamiyama Mihoko; Borges Michael; Zhang Xiaosong; Parsons D Williams; Lin Jimmy Cheng-Ho; Palmisano Emily; Brune Kieran; Jaffee Elizabeth M; Iacobuzio-Donahue Christine A; Maitra Anirban; Parmigiani Giovanni; Kern Scott E; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Eshleman James R; Goggins Michael; Klein Alison P
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
Dezentje David A; Arking Dan E; Kortenhorst Madeleine S Q; West Kristen; Chakravarti Aravinda; Kern Scott E
Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects.
Brody Jonathan R; Hucl Tomas; Costantino Christina L; Eshleman James R; Gallmeier Eike; Zhu Heng; van der Heijden Michiel S; Winter Jordan M; Wikiewicz Agnieszka K; Yeo Charles J; Kern Scott E
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.

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All Publications

2009: Jones Siân; Hruban Ralph H; Kamiyama Mihoko; Borges Michael; Zhang Xiaosong; Parsons D Williams; Lin Jimmy Cheng-Ho; Palmisano Emily; Brune Kieran; Jaffee Elizabeth M; Iacobuzio-Donahue Christine A; Maitra Anirban; Parmigiani Giovanni; Kern Scott E; Velculescu Victor E; Kinzler Kenneth W; Vogelstein Bert; Eshleman James R; Goggins Michael; Klein Alison P
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
Science (New York, N.Y.) 2009;324(5924):217.
2009: Dezentje David A; Arking Dan E; Kortenhorst Madeleine S Q; West Kristen; Chakravarti Aravinda; Kern Scott E
Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects.
Cancer biology & therapy 2009;8(4):347-55.
2009: Brody Jonathan R; Hucl Tomas; Costantino Christina L; Eshleman James R; Gallmeier Eike; Zhu Heng; van der Heijden Michiel S; Winter Jordan M; Wikiewicz Agnieszka K; Yeo Charles J; Kern Scott E
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
Cancer research 2009;69(3):984-91.
2008: Jones Siân; Zhang Xiaosong; Parsons D Williams; Lin Jimmy Cheng-Ho; Leary Rebecca J; Angenendt Philipp; Mankoo Parminder; Carter Hannah; Kamiyama Hirohiko; Jimeno Antonio; Hong Seung-Mo; Fu Baojin; Lin Ming-Tseh; Calhoun Eric S; Kamiyama Mihoko; Walter Kimberly; Nikolskaya Tatiana; Nikolsky Yuri; Hartigan James; Smith Douglas R; Hidalgo Manuel; Leach Steven D; Klein Alison P; Jaffee Elizabeth M; Goggins Michael; Maitra Anirban; Iacobuzio-Donahue Christine; Eshleman James R; Kern Scott E; Hruban Ralph H; Karchin Rachel; Papadopoulos Nickolas; Parmigiani Giovanni; Vogelstein Bert; Velculescu Victor E; Kinzler Kenneth W
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Science (New York, N.Y.) 2008;321(5897):1801-6.
2008: Hruban Ralph H; Maitra Anirban; Schulick Richard; Laheru Daniel; Herman Joseph; Kern Scott E; Goggins Michael
Emerging molecular biology of pancreatic cancer.
Gastrointestinal cancer research : GCR 2008;2(4 Suppl):S10-5.
2008: Hucl Tomas; Rago Carlo; Gallmeier Eike; Brody Jonathan R; Gorospe Myriam; Kern Scott E
A syngeneic variance library for functional annotation of human variation: application to BRCA2.
Cancer research 2008;68(13):5023-30.
2008: Showalter Shayna L; Showalter Timothy N; Witkiewicz Agnes; Havens Robert; Kennedy Eugene P; Hucl Tomas; Kern Scott E; Yeo Charles J; Brody Jonathan R
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?
Cancer biology & therapy 2008;7(7):986-94.
2008: Swanson Kenneth D; Winter Jordan M; Reis Marcelo; Bentires-Alj Mohamed; Greulich Heidi; Grewal Rupinder; Hruban Ralph H; Yeo Charles J; Yassin Yosuf; Iartchouk Oleg; Montgomery Kate; Whitman Susan P; Caligiuri Michael A; Loh Mignon L; Gilliland D Gary; Look A Thomas; Kucherlapati Raju; Kern Scott E; Meyerson Matthew; Neel Benjamin G
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Genes, chromosomes & cancer 2008;47(3):253-9.
2008: Winter Jordan M; Ting Angela H; Vilardell Felip; Gallmeier Eike; Baylin Steve B; Hruban Ralph H; Kern Scott E; Iacobuzio-Donahue Christine A
Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):412-8.
2008: Shibata Darryl K; Kern Scott E
Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis.
Breast disease 2008;29():15-25.
2008: Cao Dengfeng; Ashfaq Raheela; Goggins Michael G; Hruban Ralph H; Kern Scott E; Iacobuzio-Donahue Christine A
Differential Expression of Multiple Genes in Association with MADH4/DPC4/SMAD4 Inactivation in Pancreatic Cancer.
International journal of clinical and experimental pathology 2008;1(6):510-7.
2007: Hruban Ralph H; Maitra Anirban; Kern Scott E; Goggins Michael
Precursors to pancreatic cancer.
Gastroenterology clinics of North America 2007;36(4):831-49, vi.
2007: Hucl Tomas; Brody Jonathan R; Gallmeier Eike; Iacobuzio-Donahue Christine A; Farrance Iain K; Kern Scott E
High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.
Cancer research 2007;67(19):9055-65.
2007: Kern Scott E; Shibata Darryl
The fuzzy math of solid tumor stem cells: a perspective.
Cancer research 2007;67(19):8985-8.
2007: Hucl Tomas; Gallmeier Eike; Kern Scott E
Distinguishing rational from irrational applications of pharmacogenetic synergies from the bench to clinical trials.
Cell cycle (Georgetown, Tex.) 2007;6(11):1336-41.
2007: Gallmeier Eike; Hucl Tomas; Calhoun Eric S; Cunningham Steven C; Bunz Fred; Brody Jonathan R; Kern Scott E
Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer.
Cancer biology & therapy 2007;6(5):654-60.
2007: Foss Catherine A; Fox James J; Feldmann Georg; Maitra Anirban; Iacobuzio-Donohue Christine; Kern Scott E; Hruban Ralph; Pomper Martin G
Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of pancreatic cancer.
Molecular imaging : official journal of the Society for Molecular Imaging 2007;6(2):131-9.
2007: Gallmeier Eike; Hucl Tomas; Brody Jonathan R; Dezentje David A; Tahir Khola; Kasparkova Jana; Brabec Viktor; Bachman Kurtis E; Kern Scott E
High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.
Cancer research 2007;67(5):2169-77.
2007: Gallmeier Eike; Kern Scott E
Targeting Fanconi anemia/BRCA2 pathway defects in cancer: the significance of preclinical pharmacogenomic models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):4-10.
2007: Hruban Ralph H; Takaori Kyoichi; Canto Marcia; Fishman Elliot K; Campbell Kurtis; Brune Kieran; Kern Scott E; Goggins Michael
Clinical importance of precursor lesions in the pancreas.
Journal of hepato-biliary-pancreatic surgery 2007;14(3):255-63.
2006: Cunningham Steven C; Kamangar Farin; Kim Min P; Hammoud Sommer; Haque Raqeeb; Iacobuzio-Donahue Christine; Ashfaq Raheela; Kern Scott E; Maitra Anirban; Heitmiller Richard E; Choti Michael A; Lillemoe Keith D; Cameron John L; Yeo Charles J; Montgomery Elizabeth; Schulick Richard D
MKK4 status predicts survival after resection of gastric adenocarcinoma.
Archives of surgery (Chicago, Ill. : 1960) 2006;141(11):1095-9; discussion 1100.
2006: Calhoun Eric S; Gallmeier Eike; Cunningham Steven C; Eshleman James R; Hruban Ralph H; Kern Scott E
Copy-number methods dramatically underestimate loss of heterozygosity in cancer.
Genes, chromosomes & cancer 2006;45(11):1070-1.
2006: Brody Jonathan R; Hucl Tomas; Gallmeier Eike; Winter Jordan M; Kern Scott E; Murphy Kathleen M
Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.
Cancer research 2006;66(19):9369-73.
2006: Wood Laura D; Calhoun Eric S; Silliman Natalie; Ptak Janine; Szabo Steve; Powell Steve M; Riggins Gregory J; Wang Tian-Li; Yan Hai; Gazdar Adi; Kern Scott E; Pennacchio Len; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Human mutation 2006;27(10):1060-1.
2006: Brune Kieran; Abe Tadayoshi; Canto Marcia; O'Malley Lauren; Klein Alison P; Maitra Anirban; Volkan Adsay N; Fishman Elliot K; Cameron John L; Yeo Charles J; Kern Scott E; Goggins Michael; Hruban Ralph H
Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.
The American journal of surgical pathology 2006;30(9):1067-76.
2006: Calhoun Eric S; Hucl Tomas; Gallmeier Eike; West Kristen M; Arking Dan E; Maitra Anirban; Iacobuzio-Donahue Christine A; Chakravarti Aravinda; Hruban Ralph H; Kern Scott E
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer research 2006;66(16):7920-8.
2006: Brody Jonathan R; Gallmeier Eike; Yoshimura Kiyoshi; Hucl Tomas; Kulesza Peter; Canto Marcia I; Hruban Ralph H; Schulick Richard D; Kern Scott E
A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.
Cancer biology & therapy 2006;5(8):923-7.
2006: Gallmeier Eike; Calhoun Eric S; Rago Carlo; Brody Jonathan R; Cunningham Steven C; Hucl Tomas; Gorospe Myriam; Kohli Manu; Lengauer Christoph; Kern Scott E
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 2006;130(7):2145-54.
2006: Cunningham Steven C; Gallmeier Eike; Hucl Tomas; Dezentje David A; Calhoun Eric S; Falco Geppino; Abdelmohsen Kotb; Gorospe Myriam; Kern Scott E
Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.
Cancer research 2006;66(11):5560-4.
2006: Cunningham Steven C; Gallmeier Eike; Hucl Tomas; Dezentje David A; Abdelmohsen Kotb; Gorospe Myriam; Kern Scott E
Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers.
Cell cycle (Georgetown, Tex.) 2006;5(10):1090-3.
2006: Winter Jordan M; Brody Jonathan R; Kern Scott E
Multiple-criterion evaluation of reported mutations: a proposed scoring system for the intragenic somatic mutation literature.
Cancer biology & therapy 2006;5(4):360-70.
2006: Kern Scott E; Winter Jordan M
Elegance, silence and nonsense in the mutations literature for solid tumors.
Cancer biology & therapy 2006;5(4):349-59.
2006: Maitra Anirban; Kern Scott E; Hruban Ralph H
Molecular pathogenesis of pancreatic cancer.
Best practice & research. Clinical gastroenterology 2006;20(2):211-26.
2006: Cunningham Steven C; McNear Brad; Pearlman Rebecca S; Kern Scott E
Beverage-agarose gel electrophoresis: an inquiry-based laboratory exercise with virtual adaptation.
CBE life sciences education 2006;5(3):281-6.
2006: van der Heijden Michiel S; Brody Jonathan R; Elghalbzouri-Maghrani Elhaam; Zdzienicka Malgorzata Z; Kern Scott E
Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers.
BMC genetics 2006;7():3.
2005: van der Heijden Michiel S; Brody Jonathan R; Dezentje David A; Gallmeier Eike; Cunningham Steven C; Swartz Michael J; DeMarzo Angelo M; Offerhaus G Johan A; Isacoff William H; Hruban Ralph H; Kern Scott E
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7508-15.
2005: Hruban Ralph H; Canto Marcia I; Griffin Constance; Kern Scott E; Klein Alison P; Laheru Dan; Yeo Charles J
Treatment of familial pancreatic cancer and its precursors.
Current treatment options in gastroenterology 2005;8(5):365-75.
2005: Gallmeier Eike; Winter Jordan M; Cunningham Steven C; Kahn Saeed R; Kern Scott E
Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX.
Carcinogenesis 2005;26(10):1811-20.
2005: Matsubayashi Hiroyuki; Skinner Halcyon G; Iacobuzio-Donahue Christine; Abe Tadayoshi; Sato Norihiro; Riall Taylor Sohn; Yeo Charles J; Kern Scott E; Goggins Michael
Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005;3(8):752-60.
2005: Gallmeier Eike; Kern Scott E
Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition.
Cancer biology & therapy 2005;4(7):703-6.
2005: Hustinx Steven R; Leoni Lorenzo M; Yeo Charles J; Brown Priscilla N; Goggins Michael; Kern Scott E; Hruban Ralph H; Maitra Anirban
Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(7):959-63.
2005: Martin Sean T; Matsubayashi Hiroyuki; Rogers Carmelle D; Philips Juliet; Couch Fergus J; Brune Kieran; Yeo Charles J; Kern Scott E; Hruban Ralph H; Goggins Michael
Increased prevalence of the BRCA2 polymorphic stop codon K3326X among individuals with familial pancreatic cancer.
Oncogene 2005;24(22):3652-6.
2005: Ricci Francesca; Kern Scott E; Hruban Ralph H; Iacobuzio-Donahue Christine A
Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype.
Cancer biology & therapy 2005;4(3):302-7.
2005: Hustinx Steven R; Hruban Ralph H; Leoni Lorenzo M; Iacobuzio-Donahue Christine; Cameron John L; Yeo Charles J; Brown Priscilla N; Argani Pedram; Ashfaq Raheela; Fukushima Noriyoshi; Goggins Michael; Kern Scott E; Maitra Anirban
Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy.
Cancer biology & therapy 2005;4(1):83-6.
2004: Xin Wei; Yun Ki J; Ricci Francesca; Zahurak Marianna; Qiu Wanglong; Su Gloria H; Yeo Charles J; Hruban Ralph H; Kern Scott E; Iacobuzio-Donahue Christine A
MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8516-20.
2004: Hustinx Steven R; Cao Dengfeng; Maitra Anirban; Sato Norihiro; Martin Sean T; Sudhir D; Iacobuzio-Donahue Christine; Cameron John L; Yeo Charles J; Kern Scott E; Goggins Michael; Mollenhauer Jan; Pandey Akhilesh; Hruban Ralph H
Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression.
Cancer biology & therapy 2004;3(12):1254-61.
2004: Cao Dengfeng; Hustinx Steven R; Sui Guoping; Bala P; Sato Norihiro; Martin Sean; Maitra Anirban; Murphy Kathleen M; Cameron John L; Yeo Charles J; Kern Scott E; Goggins Michael; Pandey Akhilesh; Hruban Ralph H
Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags.
Cancer biology & therapy 2004;3(11):1081-9; discussion 1090-1.
2004: Brody Jonathan R; Calhoun Eric S; Gallmeier Eike; Creavalle Talisa D; Kern Scott E
Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media.
BioTechniques 2004;37(4):598, 600, 602.
2004: Brody Jonathan R; Kern Scott E
History and principles of conductive media for standard DNA electrophoresis.
Analytical biochemistry 2004;333(1):1-13.
2004: Brody Jonathan R; Kern Scott E
Stagnation and herd mentality in the biomedical sciences.
Cancer biology & therapy 2004;3(9):903-10.
2004: van der Heijden Michiel S; Brody Jonathan R; Gallmeier Eike; Cunningham Steven C; Dezentje David A; Shen Dong; Hruban Ralph H; Kern Scott E
Functional defects in the fanconi anemia pathway in pancreatic cancer cells.
The American journal of pathology 2004;165(2):651-7.
2004: Cunningham Steven C; Ryu Byungwoo; Sohn Taylor A; Kern Scott E
Nonspecific enhancement of gene expression by compounds identified in high-throughput cell-based screening.
BioTechniques 2004;37(1):120-2.
2004: Van Der Heijden Michiel S; Brody Jonathan R; Kern Scott E
Functional screen of the fanconi anemia pathway in cancer cells by Fancd2 immunoblot.
Cancer biology & therapy 2004;3(6):534-7.
2004: Klein Alison P; Brune Kieran A; Petersen Gloria M; Goggins Michael; Tersmette Anne C; Offerhaus G Johan A; Griffin Constance; Cameron John L; Yeo Charles J; Kern Scott; Hruban Ralph H
Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds.
Cancer research 2004;64(7):2634-8.
2004: Iacobuzio-Donahue Christine A; Song Jason; Parmiagiani Giovanni; Yeo Charles J; Hruban Ralph H; Kern Scott E
Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1597-604.
2004: Brody Jonathan R; Kern Scott E
Sodium boric acid: a Tris-free, cooler conductive medium for DNA electrophoresis.
BioTechniques 2004;36(2):214-6.
2004: Iacobuzio-Donahue Christine A; van der Heijden Michiel S; Baumgartner Mark R; Troup William J; Romm Jane M; Doheny Kimberly; Pugh Elizabeth; Yeo Charles J; Goggins Michael G; Hruban Ralph H; Kern Scott E
Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss.
Cancer research 2004;64(3):871-5.
2004: Rogers Carmelle D; van der Heijden Michiel S; Brune Kieran; Yeo Charles J; Hruban Ralph H; Kern Scott E; Goggins Michael
The genetics of FANCC and FANCG in familial pancreatic cancer.
Cancer biology & therapy 2004;3(2):167-9.
2003: Iacobuzio-Donahue Christine A; Ashfaq Raheela; Maitra Anirban; Adsay N Volkan; Shen-Ong Grace L; Berg Karin; Hollingsworth Michael A; Cameron John L; Yeo Charles J; Kern Scott E; Goggins Michael; Hruban Ralph H
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.
Cancer research 2003;63(24):8614-22.
2003: Matsubayashi Hiroyuki; Fukushima Noriyoshi; Sato Norihiro; Brune Kieran; Canto Marcia; Yeo Charles J; Hruban Ralph H; Kern Scott E; Goggins Michael
Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer.
Cancer biology & therapy 2003;2(6):652-5.
2003: Calhoun Eric S; Jones Jessa B; Ashfaq Raheela; Adsay Volkan; Baker Suzanne J; Valentine Virginia; Hempen Paula M; Hilgers Werner; Yeo Charles J; Hruban Ralph H; Kern Scott E
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
The American journal of pathology 2003;163(4):1255-60.
2003: Montgomery Elizabeth; Wilentz Robb E; Argani Pedram; Fisher Cyril; Hruban Ralph H; Kern Scott E; Lengauer Christoph
Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies.
Cancer biology & therapy 2003;2(3):248-52.
2003: van der Heijden Michiel S; Yeo Charles J; Hruban Ralph H; Kern Scott E
Fanconi anemia gene mutations in young-onset pancreatic cancer.
Cancer research 2003;63(10):2585-8.
2003: Hempen Paula M; Kurpad Harsha; Calhoun Eric S; Abraham Susan; Kern Scott E
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T.
Human mutation 2003;21(4):445.
2003: Iacobuzio-Donahue Christine A; Maitra Anirban; Olsen Mari; Lowe Anson W; van Heek N Tjarda; Rosty Christophe; Walter Kim; Sato Norihiro; Parker Antony; Ashfaq Raheela; Jaffee Elizabeth; Ryu Byungwoo; Jones Jessa; Eshleman James R; Yeo Charles J; Cameron John L; Kern Scott E; Hruban Ralph H; Brown Patrick O; Goggins Michael
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
The American journal of pathology 2003;162(4):1151-62.
2003: Ryu Byungwoo; Kern Scott E
The essential similarity of TGFbeta and activin receptor transcriptional responses in cancer cells.
Cancer biology & therapy 2003;2(2):164-70.
2003: McCarthy Denis M; Hruban Ralph H; Argani Pedram; Howe James R; Conlon Kevin C; Brennan Murray F; Zahurak Marianna; Wilentz Robb E; Cameron John L; Yeo Charles J; Kern Scott E; Klimstra David S
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003;16(3):272-8.
2003: Hempen Paula M; Zhang Lin; Bansal Ravi K; Iacobuzio-Donahue Christine A; Murphy Kathleen M; Maitra Anirban; Vogelstein Bert; Whitehead Robert H; Markowitz Sanford D; Willson James K V; Yeo Charles J; Hruban Ralph H; Kern Scott E
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Cancer research 2003;63(5):994-9.
2003: Hansel Donna E; Kern Scott E; Hruban Ralph H
Molecular pathogenesis of pancreatic cancer.
Annual review of genomics and human genetics 2003;4():237-56.
2002: Kern Scott E; Hruban Ralph H; Hidalgo Manuel; Yeo Charles J
An introduction to pancreatic adenocarcinoma genetics, pathology and therapy.
Cancer biology & therapy 2002;1(6):607-13.
2002: van Heek N Tjarda; Meeker Alan K; Kern Scott E; Yeo Charles J; Lillemoe Keith D; Cameron John L; Offerhaus G Johan A; Hicks Jessica L; Wilentz Robb E; Goggins Michael G; De Marzo Angelo M; Hruban Ralph H; Maitra Anirban
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia.
The American journal of pathology 2002;161(5):1541-7.
2002: Kern Scott E
Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law.
Cancer biology & therapy 2002;1(5):571-81.
2002: Iacobuzio-Donahue Christine A; Argani Pedram; Hempen Paula M; Jones Jessa; Kern Scott E
The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types.
Cancer research 2002;62(18):5351-7.
2002: Yeo Theresa Pluth; Hruban Ralph H; Leach Steven D; Wilentz Robb E; Sohn Taylor A; Kern Scott E; Iacobuzio-Donahue Christine A; Maitra Anirban; Goggins Michael; Canto Marcia I; Abrams Ross A; Laheru Daniel; Jaffee Elizabeth M; Hidalgo Manuel; Yeo Charles J
Pancreatic cancer.
Current problems in cancer 2002;26(4):176-275.
2002: Jaffee Elizabeth M; Hruban Ralph H; Canto Marcia; Kern Scott E
Focus on pancreas cancer.
Cancer cell 2002;2(1):25-8.
2002: Maitra Anirban; Iacobuzio-Donahue Christine; Rahman Ayman; Sohn Taylor A; Argani Peter; Meyer Renee; Yeo Charles J; Cameron John L; Goggins Michael; Kern Scott E; Ashfaq Raheela; Hruban Ralph H; Wilentz Robb E
Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47.
American journal of clinical pathology 2002;118(1):52-9.
2002: Murphy Kathleen M; Brune Kieran A; Griffin Constance; Sollenberger Jennifer E; Petersen Gloria M; Bansal Ravi; Hruban Ralph H; Kern Scott E
Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.
Cancer research 2002;62(13):3789-93.
2002: Sohn Taylor A; Bansal Ravi; Su Gloria H; Murphy Kathleen M; Kern Scott E
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.
Carcinogenesis 2002;23(6):949-57.
2002: Iacobuzio-Donahue Christine A; Maitra Anirban; Shen-Ong Grace L; van Heek Tjarda; Ashfaq Raheela; Meyer Renee; Walter Kimberly; Berg Karin; Hollingsworth Michael A; Cameron John L; Yeo Charles J; Kern Scott E; Goggins Michael; Hruban Ralph H
Discovery of novel tumor markers of pancreatic cancer using global gene expression technology.
The American journal of pathology 2002;160(4):1239-49.
2002: Kern Scott E
Quantitative selection constants.
Cancer biology & therapy 2002;1(2):189-94.
2002: Ryu Byungwoo; Jones Jessa; Blades Natalie J; Parmigiani Giovanni; Hollingsworth Michael A; Hruban Ralph H; Kern Scott E
Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression.
Cancer research 2002;62(3):819-26.
2002: Kern Scott E
Fellowship goals for PhDs and MDs: a primer on the molecular biology postdoctoral experience.
Cancer biology & therapy 2002;1(1):74-5.
2002: Lynch Henry T; Brand Randall E; Hogg David; Deters Carolyn A; Fusaro Ramon M; Lynch Jane F; Liu Ling; Knezetic Joseph; Lassam Norman J; Goggins Michael; Kern Scott
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome.
Cancer 2002;94(1):84-96.
2002: Iacobuzio-Donahue Christine A; Ryu Byungwoo; Hruban Ralph H; Kern Scott E
Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion.
The American journal of pathology 2002;160(1):91-9.
2002: Su Gloria H; Song Jason J; Repasky Elizabeth A; Schutte Mieke; Kern Scott E
Mutation rate of MAP2K4/MKK4 in breast carcinoma.
Human mutation 2002;19(1):81.
2002: Lynch Henry T; Brand Randall E; Lynch Jane F; Fusaro Ramon M; Kern Scott E
Hereditary factors in pancreatic cancer.
Journal of hepato-biliary-pancreatic surgery 2002;9(1):12-31.
2001: Tascilar M; Skinner H G; Rosty C; Sohn T; Wilentz R E; Offerhaus G J; Adsay V; Abrams R A; Cameron J L; Kern S E; Yeo C J; Hruban R H; Goggins M
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4115-21.
2001: Argani P; Iacobuzio-Donahue C; Ryu B; Rosty C; Goggins M; Wilentz R E; Murugesan S R; Leach S D; Jaffee E; Yeo C J; Cameron J L; Kern S E; Hruban R H
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):3862-8.
2001: Feldser D M; Kern S E
Oncogenic levels of mitogen-activated protein kinase (MAPK) signaling of the dinucleotide KRAS2 mutations G12F and GG12-13VC.
Human mutation 2001;18(4):357.
2001: Hruban R H; Iacobuzio-Donahue C; Wilentz R E; Goggins M; Kern S E
Molecular pathology of pancreatic cancer.
Cancer journal (Sudbury, Mass.) 2001;7(4):251-8.
2001: McCarthy D M; Brat D J; Wilentz R E; Yeo C J; Cameron J L; Kern S E; Hruban R H
Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: analysis of progression and recurrence by DPC4 immunohistochemical labeling.
Human pathology 2001;32(6):638-42.
2001: Kern S; Hruban R; Hollingsworth M A; Brand R; Adrian T E; Jaffee E; Tempero M A
A white paper: the product of a pancreas cancer think tank.
Cancer research 2001;61(12):4923-32.
2001: Argani P; Rosty C; Reiter R E; Wilentz R E; Murugesan S R; Leach S D; Ryu B; Skinner H G; Goggins M; Jaffee E M; Yeo C J; Cameron J L; Kern S E; Hruban R H
Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma.
Cancer research 2001;61(11):4320-4.
2001: Hruban R H; Adsay N V; Albores-Saavedra J; Compton C; Garrett E S; Goodman S N; Kern S E; Klimstra D S; Klöppel G; Longnecker D S; Lüttges J; Offerhaus G J
Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions.
The American journal of surgical pathology 2001;25(5):579-86.
2001: Sohn T A; Su G H; Ryu B; Yeo C J; Kern S E
High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells.
Annals of surgery 2001;233(5):696-703.
2001: Argani P; Shaukat A; Kaushal M; Wilentz R E; Su G H; Sohn T A; Yeo C J; Cameron J L; Kern S E; Hruban R H
Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts.
Cancer 2001;91(7):1332-41.
2001: Tersmette A C; Petersen G M; Offerhaus G J; Falatko F C; Brune K A; Goggins M; Rozenblum E; Wilentz R E; Yeo C J; Cameron J L; Kern S E; Hruban R H
Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):738-44.
2001: Ryu B; Jones J; Hollingsworth M A; Hruban R H; Kern S E
Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers.
Cancer research 2001;61(5):1833-8.
2001: Su G H; Bansal R; Murphy K M; Montgomery E; Yeo C J; Hruban R H; Kern S E
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3254-7.
2001: Ryu B; Song J; Sohn T; Hruban R H; Kern S E
Frequent germline deletion polymorphism of chromosomal region 8p12-p21 identified as a recurrent homozygous deletion in human tumors.
Genomics 2001;72(1):108-12.
2001: Jones J B; Song J J; Hempen P M; Parmigiani G; Hruban R H; Kern S E
Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations.
Cancer research 2001;61(4):1299-304.
2001: Montgomery E; Goggins M; Zhou S; Argani P; Wilentz R; Kaushal M; Booker S; Romans K; Bhargava P; Hruban R; Kern S
Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects.
The American journal of pathology 2001;158(2):537-42.
2000: Lynch H T; Brand R E; Lynch J F; Fusaro R M; Smyrk T C; Goggins M; Kern S E
Genetic counseling and testing for germline p16 mutations in two pancreatic cancer-prone families.
Gastroenterology 2000;119(6):1756-60.
2000: Iacobuzio-Donahue C A; Wilentz R E; Argani P; Yeo C J; Cameron J L; Kern S E; Hruban R H
Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression.
The American journal of surgical pathology 2000;24(11):1544-8.
2000: Su G H; Kern S E
Molecular genetics of ductal pancreatic neoplasia.
Current opinion in gastroenterology 2000;16(5):419-25.
2000: Iacobuzio-Donahue C A; Klimstra D S; Adsay N V; Wilentz R E; Argani P; Sohn T A; Yeo C J; Cameron J L; Kern S E; Hruban R H
Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas.
The American journal of pathology 2000;157(3):755-61.
2000: Hruban R H; Goggins M; Parsons J; Kern S E
Progression model for pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):2969-72.
2000: Jones J B; Kern S E
Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4.
Nucleic acids research 2000;28(12):2363-8.
2000: Su G H; Sohn T A; Ryu B; Kern S E
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.
Cancer research 2000;60(12):3137-42.
2000: Hruban R H; Wilentz R E; Kern S E
Genetic progression in the pancreatic ducts.
The American journal of pathology 2000;156(6):1821-5.
2000: Kern S E
Molecular genetic alterations in ductal pancreatic adenocarcinomas.
The Medical clinics of North America 2000;84(3):691-5, xi.
2000: Goggins M; Hruban R H; Kern S E
BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications.
The American journal of pathology 2000;156(5):1767-71.
2000: Wilentz R E; Goggins M; Redston M; Marcus V A; Adsay N V; Sohn T A; Kadkol S S; Yeo C J; Choti M; Zahurak M; Johnson K; Tascilar M; Offerhaus G J; Hruban R H; Kern S E
Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity.
The American journal of pathology 2000;156(5):1641-51.
2000: Wilentz R E; Iacobuzio-Donahue C A; Argani P; McCarthy D M; Parsons J L; Yeo C J; Kern S E; Hruban R H
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.
Cancer research 2000;60(7):2002-6.
2000: Hilgers W; Song J J; Haye M; Hruban R R; Kern S E; Fearon E R
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.
Genes, chromosomes & cancer 2000;27(4):353-7.
2000: Geradts J; Hruban R H; Schutte M; Kern S E; Maynard R
Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2000;8(1):71-9.
2000: Hilgers W; Groot Koerkamp B; Geradts J; Tang D J; Yeo C J; Hruban R H; Kern S E
Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas.
Genes, chromosomes & cancer 2000;27(3):239-43.
2000: Wilentz R E; Su G H; Dai J L; Sparks A B; Argani P; Sohn T A; Yeo C J; Kern S E; Hruban R H
Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation.
The American journal of pathology 2000;156(1):37-43.
1999: Rijken A M; Hu J; Perlman E J; Morsberger L A; Long P; Kern S E; Hruban R H; Yeo C J; Griffin C A
Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis.
Genes, chromosomes & cancer 1999;26(3):185-91.
1999: Hruban R H; Goggins M; Kern S E
Molecular genetics and related developments in pancreatic cancer.
Current opinion in gastroenterology 1999;15(5):404-9.
1999: Dai J L; Schutte M; Bansal R K; Wilentz R E; Sugar A Y; Kern S E
Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells.
Molecular carcinogenesis 1999;26(1):37-43.
1999: Hilgers W; Kern S E
Molecular genetic basis of pancreatic adenocarcinoma.
Genes, chromosomes & cancer 1999;26(1):1-12.
1999: Hilgers W; Su G H; Groot Koerkamp B; Tang D J; Shekher M C; Sugar A Y; Yeo C J; Hruban R H; Kern S E
Novel homozygous deletions of chromosomal band 18q22 in pancreatic adenocarcinoma identified by STS marker scanning.
Genes, chromosomes & cancer 1999;25(4):370-5.
1999: Su G H; Hruban R H; Bansal R K; Bova G S; Tang D J; Shekher M C; Westerman A M; Entius M M; Goggins M; Yeo C J; Kern S E
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.
The American journal of pathology 1999;154(6):1835-40.
1999: Hilgers W; Tang D J; Sugar A Y; Shekher M C; Hruban R H; Kern S E
High-resolution deletion mapping of chromosome arm 1p in pancreatic cancer identifies a major consensus region at 1p35.
Genes, chromosomes & cancer 1999;24(4):351-5.
1999: Dai J L; Bansal R K; Kern S E
G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1427-32.
1999: Hruban R H; Petersen G M; Goggins M; Tersmette A C; Offerhaus G J; Falatko F; Yeo C J; Kern S E
Familial pancreatic cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():69-73.
1999: Hruban R H; Wilentz R E; Goggins M; Offerhaus G J; Yeo C J; Kern S E
Pathology of incipient pancreatic cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():9-11.
1999: Goggins M; Kern S E; Offerhaus J A; Hruban R H
Progress in cancer genetics: lessons from pancreatic cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():4-8.
1998: Kibel A S; Schutte M; Kern S E; Isaacs W B; Bova G S
Identification of 12p as a region of frequent deletion in advanced prostate cancer.
Cancer research 1998;58(24):5652-5.
1998: Goggins M; Shekher M; Turnacioglu K; Yeo C J; Hruban R H; Kern S E
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.
Cancer research 1998;58(23):5329-32.
1998: Goggins M; Lietman A; Miller R E; Yeo C J; Jaffee E; Coleman J; O'Reilly S; Cullen B; Cameron J L; Kern S E; Hruban R H
Use and benefits of a Web site for pancreatic cancer.
JAMA : the journal of the American Medical Association 1998;280(15):1309-10.
1998: Wilentz R E; Geradts J; Maynard R; Offerhaus G J; Kang M; Goggins M; Yeo C J; Kern S E; Hruban R H
Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression.
Cancer research 1998;58(20):4740-4.
1998: Dai J L; Turnacioglu K K; Schutte M; Sugar A Y; Kern S E
Dpc4 transcriptional activation and dysfunction in cancer cells.
Cancer research 1998;58(20):4592-7.
1998: Jaffee E M; Abrams R; Cameron J; Donehower R; Duerr M; Gossett J; Greten T F; Grochow L; Hruban R; Kern S; Lillemoe K D; O'Reilly S; Pardoll D; Pitt H A; Sauter P; Weber C; Yeo C
A phase I clinical trial of lethally irradiated allogeneic pancreatic tumor cells transfected with the GM-CSF gene for the treatment of pancreatic adenocarcinoma.
Human gene therapy 1998;9(13):1951-71.
1998: Mank-Seymour A R; Murray T R; Berkey K A; Xiao L; Kern S; Casero R A
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(8):2003-8.
1998: Goggins M; Offerhaus G J; Hilgers W; Griffin C A; Shekher M; Tang D; Sohn T A; Yeo C J; Kern S E; Hruban R H
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
The American journal of pathology 1998;152(6):1501-7.
1998: Su G H; Hilgers W; Shekher M C; Tang D J; Yeo C J; Hruban R H; Kern S E
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
Cancer research 1998;58(11):2339-42.
1998: Zawel L; Dai J L; Buckhaults P; Zhou S; Kinzler K W; Vogelstein B; Kern S E
Human Smad3 and Smad4 are sequence-specific transcription activators.
Molecular cell 1998;1(4):611-7.
1998: Zhou S; Buckhaults P; Zawel L; Bunz F; Riggins G; Dai J L; Kern S E; Kinzler K W; Vogelstein B
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2412-6.
1998: Zhou W; Sokoll L J; Bruzek D J; Zhang L; Velculescu V E; Goldin S B; Hruban R H; Kern S E; Hamilton S R; Chan D W; Vogelstein B; Kinzler K W
Identifying markers for pancreatic cancer by gene expression analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(2):109-12.
1998: Okami K; Wu L; Riggins G; Cairns P; Goggins M; Evron E; Halachmi N; Ahrendt S A; Reed A L; Hilgers W; Kern S E; Koch W M; Sidransky D; Jen J
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Cancer research 1998;58(3):509-11.
1998: Kern S E
Advances from genetic clues in pancreatic cancer.
Current opinion in oncology 1998;10(1):74-80.
1998: Hruban R H; Petersen G M; Ha P K; Kern S E
Genetics of pancreatic cancer. From genes to families.
Surgical oncology clinics of North America 1998;7(1):1-23.
1998: Sirard C; de la Pompa J L; Elia A; Itie A; Mirtsos C; Cheung A; Hahn S; Wakeham A; Schwartz L; Kern S E; Rossant J; Mak T W
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Genes & development 1998;12(1):107-19.
1998: Moskaluk C A; Hruban H; Lietman A; Smyrk T; Fusaro L; Fusaro R; Lynch J; Yeo C J; Jackson C E; Lynch H T; Kern S E
Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online.
Human mutation 1998;12(1):70.
1998: Hruban R H; Offerhaus G J; Kern S E; Goggins M; Wilentz R E; Yeo C J
Tumor-suppressor genes in pancreatic cancer.
Journal of hepato-biliary-pancreatic surgery 1998;5(4):383-91.
1997: Schutte M; Hruban R H; Geradts J; Maynard R; Hilgers W; Rabindran S K; Moskaluk C A; Hahn S A; Schwarte-Waldhoff I; Schmiegel W; Baylin S B; Kern S E; Herman J G
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
Cancer research 1997;57(15):3126-30.
1997: Moskaluk C A; Hruban R H; Kern S E
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Cancer research 1997;57(11):2140-3.
1997: Zhang L; Zhou W; Velculescu V E; Kern S E; Hruban R H; Hamilton S R; Vogelstein B; Kinzler K W
Gene expression profiles in normal and cancer cells.
Science (New York, N.Y.) 1997;276(5316):1268-72.
1997: Moskaluk C A; Kern S E
Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections.
The American journal of pathology 1997;150(5):1547-52.
1997: Rozenblum E; Schutte M; Goggins M; Hahn S A; Panzer S; Zahurak M; Goodman S N; Sohn T A; Hruban R H; Yeo C J; Kern S E
Tumor-suppressive pathways in pancreatic carcinoma.
Cancer research 1997;57(9):1731-4.
1997: Moskaluk C A; Hruban R H; Schutte M; Lietman A S; Smyrk T; Fusaro L; Fusaro R; Lynch J; Yeo C J; Jackson C E; Lynch H T; Kern S E
Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1997;6(2):85-90.
1997: Brat D J; Hahn S A; Griffin C A; Yeo C J; Kern S E; Hruban R H
The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma.
The American journal of pathology 1997;150(2):383-91.
1997: Hoque A T; Hahn S A; Schutte M; Kern S E
DPC4 gene mutation in colitis associated neoplasia.
Gut 1997;40(1):120-2.
1996: Moskaluk C A; Kern S E
Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer.
Biochimica et biophysica acta 1996;1288(3):M31-3.
1996: Goggins M; Schutte M; Lu J; Moskaluk C A; Weinstein C L; Petersen G M; Yeo C J; Jackson C E; Lynch H T; Hruban R H; Kern S E
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.
Cancer research 1996;56(23):5360-4.
1996: Derynck R; Gelbart W M; Harland R M; Heldin C H; Kern S E; Massagué J; Melton D A; Mlodzik M; Padgett R W; Roberts A B; Smith J; Thomsen G H; Vogelstein B; Wang X F
Nomenclature: vertebrate mediators of TGFbeta family signals.
Cell 1996;87(2):173.
1996: Barrett M T; Schutte M; Kern S E; Reid B J
Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma.
Cancer research 1996;56(19):4351-3.
1996: Riggins G J; Thiagalingam S; Rozenblum E; Weinstein C L; Kern S E; Hamilton S R; Willson J K; Markowitz S D; Kinzler K W; Vogelstein B
Mad-related genes in the human.
Nature genetics 1996;13(3):347-9.
1996: Thiagalingam S; Lengauer C; Leach F S; Schutte M; Hahn S A; Overhauser J; Willson J K; Markowitz S; Hamilton S R; Kern S E; Kinzler K W; Vogelstein B
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Nature genetics 1996;13(3):343-6.
1996: Schutte M; Hruban R H; Hedrick L; Cho K R; Nadasdy G M; Weinstein C L; Bova G S; Isaacs W B; Cairns P; Nawroz H; Sidransky D; Casero R A; Meltzer P S; Hahn S A; Kern S E
DPC4 gene in various tumor types.
Cancer research 1996;56(11):2527-30.
1996: Lynch H T; Smyrk T; Kern S E; Hruban R H; Lightdale C J; Lemon S J; Lynch J F; Fusaro L R; Fusaro R M; Ghadirian P
Familial pancreatic cancer: a review.
Seminars in oncology 1996;23(2):251-75.
1996: Day J D; Digiuseppe J A; Yeo C; Lai-Goldman M; Anderson S M; Goodman S N; Kern S E; Hruban R H
Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms.
Human pathology 1996;27(2):119-24.
1996: Hahn S A; Hoque A T; Moskaluk C A; da Costa L T; Schutte M; Rozenblum E; Seymour A B; Weinstein C L; Yeo C J; Hruban R H; Kern S E
Homozygous deletion map at 18q21.1 in pancreatic cancer.
Cancer research 1996;56(3):490-4.
1996: Hahn S A; Schutte M; Hoque A T; Moskaluk C A; da Costa L T; Rozenblum E; Weinstein C L; Fischer A; Yeo C J; Hruban R H; Kern S E
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
Science (New York, N.Y.) 1996;271(5247):350-3.
1995: Hahn S A; Kern S E
Molecular genetics of exocrine pancreatic neoplasms.
The Surgical clinics of North America 1995;75(5):857-69.
1995: DiGiuseppe J A; Redston M S; Yeo C J; Kern S E; Hruban R H
p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.
The American journal of pathology 1995;147(4):884-8.
1995: Schutte M; Rozenblum E; Moskaluk C A; Guan X; Hoque A T; Hahn S A; da Costa L T; de Jong P J; Kern S E
An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12.
Cancer research 1995;55(20):4570-4.
1995: Schutte M; da Costa L T; Moskaluk C A; Rozenblum E; Guan X; de Jong P J; Bittner M; Meltzer P S; Trent J M; Kern S E
Isolation of YAC insert sequences by representational difference analysis.
Nucleic acids research 1995;23(20):4127-33.
1995: Caldas C; Kern S E
K-ras mutation and pancreatic adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology 1995;18(1):1-6.
1995: Redston M S; Papadopoulos N; Caldas C; Kinzler K W; Kern S E
Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.
Gastroenterology 1995;108(2):383-92.
1994: Caldas C; Hahn S A; da Costa L T; Redston M S; Schutte M; Seymour A B; Weinstein C L; Hruban R H; Yeo C J; Kern S E
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.
Nature genetics 1994;8(1):27-32.
1994: Kern S E; Redston M; Seymour A B; Caldas C; Powell S M; Kornacki S; Kinzler K W
Molecular genetic profiles of colitis-associated neoplasms.
Gastroenterology 1994;107(2):420-8.
1994: Redston M S; Kern S E
Klenow co-sequencing: a method for eliminating "stops".
BioTechniques 1994;17(2):286, 288.
1994: Caldas C; Hahn S A; Hruban R H; Redston M S; Yeo C J; Kern S E
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Cancer research 1994;54(13):3568-73.
1994: Kern S E
p53: tumor suppression through control of the cell cycle.
Gastroenterology 1994;106(6):1708-11.
1994: Redston M S; Caldas C; Seymour A B; Hruban R H; da Costa L; Yeo C J; Kern S E
p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions.
Cancer research 1994;54(11):3025-33.
1994: Seymour A B; Hruban R H; Redston M; Caldas C; Powell S M; Kinzler K W; Yeo C J; Kern S E
Allelotype of pancreatic adenocarcinoma.
Cancer research 1994;54(10):2761-4.
1993: Hamilton S R; Kern S E
Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma and molecular genetics of colorectal carcinoma.
Cancer 1993;72(3):957.
1993: Kern S E
Clonality: more than just a tumor-progression model.
Journal of the National Cancer Institute 1993;85(13):1020-1.
1992: Mulder J W; Offerhaus G J; de Feyter E P; Floyd J J; Kern S E; Vogelstein B; Hamilton S R
The relationship of quantitative nuclear morphology to molecular genetic alterations in the adenoma-carcinoma sequence of the large bowel.
The American journal of pathology 1992;141(4):797-804.
1992: Kern S E; Pietenpol J A; Thiagalingam S; Seymour A; Kinzler K W; Vogelstein B
Oncogenic forms of p53 inhibit p53-regulated gene expression.
Science (New York, N.Y.) 1992;256(5058):827-30.
1992: Offerhaus G J; De Feyter E P; Cornelisse C J; Tersmette K W; Floyd J; Kern S E; Vogelstein B; Hamilton S R
The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma.
Gastroenterology 1992;102(5):1612-9.
1992: Fong C T; White P S; Peterson K; Sapienza C; Cavenee W K; Kern S E; Vogelstein B; Cantor A B; Look A T; Brodeur G M
Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas.
Cancer research 1992;52(7):1780-5.
1992: el-Deiry W S; Kern S E; Pietenpol J A; Kinzler K W; Vogelstein B
Definition of a consensus binding site for p53.
Nature genetics 1992;1(1):45-9.
1991: Giardiello F M; Hamilton S R; Kern S E; Offerhaus G J; Green P A; Celano P; Krush A J; Booker S V
Colorectal neoplasia in juvenile polyposis or juvenile polyps.
Archives of disease in childhood 1991;66(8):971-5.
1991: Kern S E; Kinzler K W; Bruskin A; Jarosz D; Friedman P; Prives C; Vogelstein B
Identification of p53 as a sequence-specific DNA-binding protein.
Science (New York, N.Y.) 1991;252(5013):1708-11.
1991: Bargonetti J; Friedman P N; Kern S E; Vogelstein B; Prives C
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication.
Cell 1991;65(6):1083-91.
1991: Nigro J M; Cho K R; Fearon E R; Kern S E; Ruppert J M; Oliner J D; Kinzler K W; Vogelstein B
Scrambled exons.
Cell 1991;64(3):607-13.
1991: Urban B A; Jones B; Fishman E K; Kern S E; Ravich W J
Gastric antral vascular ectasia ("watermelon stomach"): radiologic findings.
Radiology 1991;178(2):517-8.
1991: Kern S E; Kinzler K W; Baker S J; Nigro J M; Rotter V; Levine A J; Friedman P; Prives C; Vogelstein B
Mutant p53 proteins bind DNA abnormally in vitro.
Oncogene 1991;6(1):131-6.
1990: Friedman P N; Kern S E; Vogelstein B; Prives C
Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9275-9.
1990: Kern S E; Yardley J H; Lazenby A J; Boitnott J K; Yang V W; Bayless T M; Sitzmann J V
Reversal by antrectomy of endocrine cell hyperplasia in the gastric body in pernicious anemia: a morphometric study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1990;3(5):561-6.
1990: Fearon E R; Cho K R; Nigro J M; Kern S E; Simons J W; Ruppert J M; Hamilton S R; Preisinger A C; Thomas G; Kinzler K W
Identification of a chromosome 18q gene that is altered in colorectal cancers.
Science (New York, N.Y.) 1990;247(4938):49-56.
1989: Kern S E; Fearon E R; Tersmette K W; Enterline J P; Leppert M; Nakamura Y; White R; Vogelstein B; Hamilton S R
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]
JAMA : the journal of the American Medical Association 1989;261(21):3099-103.
1989: Vogelstein B; Fearon E R; Kern S E; Hamilton S R; Preisinger A C; Nakamura Y; White R
Allelotype of colorectal carcinomas.
Science (New York, N.Y.) 1989;244(4901):207-11.
1989: Kern S E; Yardley J H; Kafonek D R; Epstein J I; Edlow D W; Morrison S; Moore G W; Gebhardt F C; Diamond M P
Three cases of gastric spirochetelike organisms.
Gastroenterology 1989;96(1):266-8.
1988: Vogelstein B; Fearon E R; Hamilton S R; Kern S E; Preisinger A C; Leppert M; Nakamura Y; White R; Smits A M; Bos J L
Genetic alterations during colorectal-tumor development.
The New England journal of medicine 1988;319(9):525-32.
1987: Kern S E; Keren D F; Pierson C L
Bacterial overgrowth and mucosal changes in isolated (Thirty-Vella) ileal loops in rabbits. Effects of intraluminal antibiotics.
Laboratory investigation; a journal of technical methods and pathology 1987;57(3):336-41.
1987: Kern S E; Keren D F; Beals T F; Varani J
A model for Paneth cell study: tissue culture of the hyperplastic Paneth cell population of rabbit Thiry-Vella ileal loops.
Advances in experimental medicine and biology 1987;216A():419-26.
1985: Kern S E; Cowen M E; Abrams G D
Malignant fibrous histiocytoma of the heart presenting as unilateral pulmonary thromboembolism and infarct.
Human pathology 1985;16(12):1279-81.
1983: Keren D F; Scott P J; McDonald R A; Kern S E
Local IgA-memory response to bacterial antigens.
Annals of the New York Academy of Sciences 1983;409():734-44.
1982: Keren D F; Kern S E; Bauer D H; Scott P J; Porter P
Direct demonstration in intestinal secretions of an IgA memory response to orally administered Shigella flexneri antigens.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(1):475-9.

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