Timothy Kern

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Kern Timothy S; Berkowitz Bruce A; Feldman Eva L
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) meeting summary: Advances toward measuring diabetic retinopathy and neuropathy: from the bench to the clinic and back again (April 4-5, 2007, Baltimore, Maryland).
Shelton Melissa D; Distler Anne M; Kern Timothy S; Mieyal John J
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells.
Portillo Jose-Andres C; Okenka Genevieve; Kern Timothy S; Subauste Carlos S
Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry.

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All Publications

2009: Kern Timothy S; Berkowitz Bruce A; Feldman Eva L
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) meeting summary: Advances toward measuring diabetic retinopathy and neuropathy: from the bench to the clinic and back again (April 4-5, 2007, Baltimore, Maryland).
Journal of diabetes and its complications 2009;23(3):219-23.
2009: Shelton Melissa D; Distler Anne M; Kern Timothy S; Mieyal John J
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells.
The Journal of biological chemistry 2009;284(8):4760-6.
2009: Portillo Jose-Andres C; Okenka Genevieve; Kern Timothy S; Subauste Carlos S
Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry.
Molecular vision 2009;15():1383-9.
2008: Portillo Jose-Andres C; Van Grol Jennifer; Zheng Ling; Okenka Genevieve; Gentil Katrin; Garland Alejandra; Carlson Eric C; Kern Timothy S; Subauste Carlos S
CD40 mediates retinal inflammation and neurovascular degeneration.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8719-26.
2008: Berti-Mattera Liliana N; Kern Timothy S; Siegel Ruth E; Nemet Ina; Mitchell Rochanda
Sulfasalazine blocks the development of tactile allodynia in diabetic rats.
Diabetes 2008;57(10):2801-8.
2008: Kern Timothy S; Barber Alistair J
Retinal ganglion cells in diabetes.
The Journal of physiology 2008;586(Pt 18):4401-8.
2008: Gubitosi-Klug Rose A; Talahalli Ramaprasad; Du Yunpeng; Nadler Jerry L; Kern Timothy S
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.
Diabetes 2008;57(5):1387-93.
2007: Zhang Jin-Zhong; Xi Xia; Gao Ling; Kern Timothy S
Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy.
Current eye research 2007;32(10):883-9.
2007: Zheng L; Du Y; Miller C; Gubitosi-Klug R A; Ball S; Berkowitz B A; Kern T S
Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes.
Diabetologia 2007;50(9):1987-96.
2007: Kanwar Mamta; Chan Pooi-See; Kern Timothy S; Kowluru Renu A
Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase.
Investigative ophthalmology & visual science 2007;48(8):3805-11.
2007: Shelton Melissa D; Kern Timothy S; Mieyal John J
Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy.
The Journal of biological chemistry 2007;282(17):12467-74.
2007: Kern Timothy S; Miller Casey M; Du Yunpeng; Zheng Ling; Mohr Susanne; Ball Sherry L; Kim M; Jamison Jeffrey A; Bingaman David P
Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology.
Diabetes 2007;56(2):373-9.
2007: Zheng Ling; Howell Scott J; Hatala Denise A; Huang Kun; Kern Timothy S
Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy.
Diabetes 2007;56(2):337-45.
2007: Zheng Ling; Gong Bendi; Hatala Denise A; Kern Timothy S
Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes.
Investigative ophthalmology & visual science 2007;48(1):361-7.
2007: Kern Timothy S
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy.
Experimental diabetes research 2007;2007():95103.
2006: Mishra Rangnath; Emancipator Steven N; Kern Timothy S; Simonson Michael S
Association between endothelin-1 and collagen deposition in db/db diabetic mouse kidneys.
Biochemical and biophysical research communications 2006;339(1):65-70.
2005: Feit-Leichman Rachel A; Kinouchi Reiko; Takeda Masumi; Fan Zhigang; Mohr Susanne; Kern Timothy S; Chen Dong Feng
Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.
Investigative ophthalmology & visual science 2005;46(11):4281-7.
2005: Rosca Mariana G; Mustata Tiberiu G; Kinter Michael T; Ozdemir Aylin M; Kern Timothy S; Szweda Luke I; Brownlee Michael; Monnier Vincent M; Weiss Miriam F
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
American journal of physiology. Renal physiology 2005;289(2):F420-30.
2005: Mustata Georgian T; Rosca Mariana; Biemel Klaus M; Reihl Oliver; Smith Mark A; Viswanathan Ashwini; Strauch Christopher; Du Yunpeng; Tang Jie; Kern Timothy S; Lederer Markus O; Brownlee Michael; Weiss Miriam F; Monnier Vincent M
Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.
Diabetes 2005;54(2):517-26.
2005: Mishra Rangnath; Emancipator Steven N; Kern Timothy; Simonson Michael S
High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells.
Kidney international 2005;67(1):82-93.
2005: Xi Xia; Gao Ling; Hatala Denise A; Smith Dawn G; Codispoti Maria C; Gong Bendi; Kern Timothy S; Zhang Jin-Zhong
Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells.
Biochemical and biophysical research communications 2005;326(3):548-53.
2004: Zheng Ling; Szabó Csaba; Kern Timothy S
Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.
Diabetes 2004;53(11):2960-7.
2004: Mishra Rangnath; Emancipator Steven N; Miller Casey; Kern Timothy; Simonson Michael S
Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney.
American journal of physiology. Renal physiology 2004;286(5):F913-21.
2004: Puchowicz Michelle A; Xu Kui; Magness Danielle; Miller Casey; Lust W David; Kern Timothy S; LaManna Joseph C
Comparison of glucose influx and blood flow in retina and brain of diabetic rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(4):449-57.
2004: Berkowitz Bruce A; Luan Hongmei; Gupta Rita R; Pacheco Daniel; Seidner Andres; Roberts Robin; Liggett Jessica; Knoerzer Deborah L; Connor Jane R; Du Yunpeng; Kern Timothy S; Ito Yasuki
Regulation of the early subnormal retinal oxygenation response in experimental diabetes by inducible nitric oxide synthase.
Diabetes 2004;53(1):173-8.
2003: Du Yunpeng; Miller Casey M; Kern T S
Hyperglycemia increases mitochondrial superoxide in retina and retinal cells.
Free radical biology & medicine 2003;35(11):1491-9.
2003: Zhang Jin-Zhong; Gao Ling; Widness Mi; Xi Xia; Kern Timothy S
Captopril inhibits glucose accumulation in retinal cells in diabetes.
Investigative ophthalmology & visual science 2003;44(9):4001-5.
2003: Xi Jinghua; Farjo Rafal; Yoshida Shigeo; Kern Timothy S; Swaroop Anand; Andley Usha P
A comprehensive analysis of the expression of crystallins in mouse retina.
Molecular vision 2003;9():410-9.
2002: Romeo Giulio; Liu Wei-Hua; Asnaghi Veronica; Kern Timothy S; Lorenzi Mara
Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes.
Diabetes 2002;51(7):2241-8.
2002: Mohr Susanne; Xi Xia; Tang Jie; Kern Timothy S
Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients.
Diabetes 2002;51(4):1172-9.
2002: Du Yunpeng; Smith Mark A; Miller Casey M; Kern T S
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
Journal of neurochemistry 2002;80(5):771-9.
2001: Berkowitz B A; Ito Y; Kern T S; McDonald C; Hawkins R
Correction of early subnormal superior hemiretinal DeltaPO(2) predicts therapeutic efficacy in experimental diabetic retinopathy.
Investigative ophthalmology & visual science 2001;42(12):2964-9.
2001: Kowluru R A; Tang J; Kern T S
Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.
Diabetes 2001;50(8):1938-42.
2001: Kern T S; Engerman R L
Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin.
Diabetes 2001;50(7):1636-42.
2001: Kowluru R A; Engerman R L; Case G L; Kern T S
Retinal glutamate in diabetes and effect of antioxidants.
Neurochemistry international 2001;38(5):385-90.
2000: Tang J; Zhu X W; Lust W D; Kern T S
Retina accumulates more glucose than does the embryologically similar cerebral cortex in diabetic rats.
Diabetologia 2000;43(11):1417-23.
2000: Kern T S; Tang J; Mizutani M; Kowluru R A; Nagaraj R H; Romeo G; Podesta F; Lorenzi M
Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia.
Investigative ophthalmology & visual science 2000;41(12):3972-8.
2000: Kowluru R A; Engerman R L; Kern T S
Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine.
Current eye research 2000;21(4):814-9.
2000: Badr G A; Tang J; Ismail-Beigi F; Kern T S
Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels.
Diabetes 2000;49(6):1016-21.
2000: Kowluru R A; Engerman R L; Kern T S
Diabetes-induced metabolic abnormalities in myocardium: effect of antioxidant therapy.
Free radical research 2000;32(1):67-74.
1999: Berkowitz B A; Kowluru R A; Frank R N; Kern T S; Hohman T C; Prakash M
Subnormal retinal oxygenation response precedes diabetic-like retinopathy.
Investigative ophthalmology & visual science 1999;40(9):2100-5.
1999: Kowluru R A; Engerman R L; Kern T S
Abnormalities of retinal metabolism in diabetes or experimental galactosemia. VI. Comparison of retinal and cerebral cortex metabolism, and effects of antioxidant therapy.
Free radical biology & medicine 1999;26(3-4):371-8.
1999: Kern T S; Engerman R L
Aldose reductase and the development of renal disease in diabetic dogs.
Journal of diabetes and its complications 1999;13(1):10-6.
1999: Badr G A; Zhang J Z; Tang J; Kern T S; Ismail-Beigi F
Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina.
Brain research. Molecular brain research 1999;64(1):24-33.
1998: Engerman R L; Kern T S
Retinopathy and tissue hexose in drug-treated animals.
Archives of ophthalmology 1998;116(4):543-4.
1998: Kowluru R A; Jirousek M R; Stramm L; Farid N; Engerman R L; Kern T S
Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.
Diabetes 1998;47(3):464-9.
1997: Kowluru R A; Kern T S; Engerman R L
Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system.
Free radical biology & medicine 1997;22(4):587-92.
1996: Kowluru R A; Kern T S; Engerman R L; Armstrong D
Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants.
Diabetes 1996;45(9):1233-7.
1996: Kern T S; Engerman R L
A mouse model of diabetic retinopathy.
Archives of ophthalmology 1996;114(8):986-90.
1996: Ishii H; Jirousek M R; Koya D; Takagi C; Xia P; Clermont A; Bursell S E; Kern T S; Ballas L M; Heath W F; Stramm L E; Feener E P; King G L
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Science (New York, N.Y.) 1996;272(5262):728-31.
1996: Kern T S; Engerman R L
Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia.
Archives of ophthalmology 1996;114(3):306-10.
1995: Engerman R L; Kern T S
Retinopathy in galactosemic dogs continues to progress after cessation of galactosemia.
Archives of ophthalmology 1995;113(3):355-8.
1995: Kern T S; Engerman R L
Galactose-induced retinal microangiopathy in rats.
Investigative ophthalmology & visual science 1995;36(2):490-6.
1994: Kowluru R; Kern T S; Engerman R L
Abnormalities of retinal metabolism in diabetes or galactosemia. II. Comparison of gamma-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy.
Current eye research 1994;13(12):891-6.
1994: Kern T S; Engerman R L
Comparison of retinal lesions in alloxan-diabetic rats and galactose-fed rats.
Current eye research 1994;13(12):863-7.
1994: Xia P; Inoguchi T; Kern T S; Engerman R L; Oates P J; King G L
Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia.
Diabetes 1994;43(9):1122-9.
1994: Kern T S; Kowluru R A; Engerman R L
Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione.
Investigative ophthalmology & visual science 1994;35(7):2962-7.
1994: Engerman R L; Kern T S; Larson M E
Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs.
Diabetologia 1994;37(2):141-4.
1993: Engerman R L; Kern T S; Garment M B
Capillary basement membrane in retina, kidney, and muscle of diabetic dogs and galactosemic dogs and its response to 5 years aldose reductase inhibition.
Journal of diabetes and its complications 1993;7(4):241-5.
1993: Engerman R L; Kern T S
Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs.
Diabetes 1993;42(6):820-5.
1991: Kern T S; Engerman R L
Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor.
Investigative ophthalmology & visual science 1991;32(13):3175-7.
1991: Kern T S; Engerman R L
Renal hemodynamics in experimentally galactosemic dogs and diabetic dogs.
Metabolism: clinical and experimental 1991;40(5):450-4.
1990: Kern T S; Engerman R L
Arrest of glomerulopathy in diabetic dogs by improved glycaemic control.
Diabetologia 1990;33(9):522-5.
1990: Engerman R L; Kern T S; Larson M E
Nerve conduction velocity in dogs is reduced by diabetes and not by galactosemia.
Metabolism: clinical and experimental 1990;39(6):638-40.
1989: Kern T S; Engerman R L
Comparison of DNA breaks in diabetic dogs and galactosemic dogs developing retinopathy.
Current eye research 1989;8(8):765-9.
1989: Engerman R L; Kern T S
Hyperglycemia and development of glomerular pathology: diabetes compared with galactosemia.
Kidney international 1989;36(1):41-5.
1989: Kern T S; Engerman R L; Peterson C M
Elevated blood viscosity in alloxan diabetic dogs and experimentally galactosemic dogs.
The Journal of diabetic complications 1989;3(3):158-62.
1988: Kern T S; Engerman R L
Urinary protein excretion rates in experimentally diabetic dogs and experimentally galactosaemic dogs.
Diabetologia 1988;31(12):928-32.

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Timothy Kern

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