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Glenn Kerrick

Research Profile

Chemicals & Drugs

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Myocardial Contraction

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TOP 3
Yuhui Wen; Yuanyuan Xu; Ying Wang; Jose Renato Pinto; James D Potter; W Glenn L Kerrick
Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice.
Katarzyna Kazmierczak; Yuanyuan Xu; Michelle Jones; Georgianna Guzman; Olga M Hernandez; W Glenn L Kerrick; Danuta Szczesna-Cordary
The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction.
W Glenn L Kerrick; Katarzyna Kazmierczak; Yuanyuan Xu; Ying Wang; Danuta Szczesna-Cordary
Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice.

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All Publications

2009: Yuhui Wen; Yuanyuan Xu; Ying Wang; Jose Renato Pinto; James D Potter; W Glenn L Kerrick
Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice.
Journal of molecular biology 2009;392(5):1158-67.
2009: Katarzyna Kazmierczak; Yuanyuan Xu; Michelle Jones; Georgianna Guzman; Olga M Hernandez; W Glenn L Kerrick; Danuta Szczesna-Cordary
The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction.
Journal of molecular biology 2009;387(3):706-25.
2009: W Glenn L Kerrick; Katarzyna Kazmierczak; Yuanyuan Xu; Ying Wang; Danuta Szczesna-Cordary
Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):855-65.
2008: Yuhui Wen; Jose Renato Pinto; Aldrin Gomes; Yuanyuan Xu; Ying Wang; Ying Wang; James D Potter; W Glenn L Kerrick
Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice.
The Journal of biological chemistry 2008;283(29):20484-94.
2007: Xiaohua Shen; Clara Franzini-Armstrong; Jose R Lopez; Larry R Jones; Yvonne M Kobayashi; Ying Wang; W Glenn L Kerrick; Anthony H Caswell; James D Potter; Todd Miller; Paul D Allen; Claudio F Perez
Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle.
The Journal of biological chemistry 2007;282(52):37864-74.
2007: Danuta Szczesna-Cordary; Michelle Jones; Jeffrey R Moore; James Watt; W Glenn L Kerrick; Yuanyuan Xu; Ying Wang; Cory Wagg; Gary D Lopaschuk
Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(14):3974-85.
2006: Ying Wang; Yuanyuan Xu; W Glenn L Kerrick; Yingcai Wang; Georgianna Guzman; Zoraida Diaz-Perez; Danuta Szczesna-Cordary
Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations.
Journal of molecular biology 2006;361(2):286-99.
2005: Olga M Hernandez; Danuta Szczesna-Cordary; Björn C Knollmann; Todd Miller; Michael Bell; Jiaju Zhao; Syevda G Sirenko; Zoraida Diaz; Georgianna Guzman; Yuanyuan Xu; Ying Wang; W Glenn L Kerrick; James D Potter
F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers.
The Journal of biological chemistry 2005;280(44):37183-94.
2005: Gayathri Venkatraman; Aldrin Gomes; W Glenn L Kerrick; James D Potter
Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform.
The Journal of biological chemistry 2005;280(18):17584-92.
2004: W Glenn L Kerrick; Yuanyuan Xu
Inorganic phosphate affects the pCa-force relationship more than the pCa-ATPase by increasing the rate of dissociation of force generating cross-bridges in skinned fibers from both EDL and soleus muscles of the rat.
Journal of muscle research and cell motility 2004;25(2):107-17.
2003: Gayathri Venkatraman; Keita Harada; Aldrin Gomes; W Glenn L Kerrick; James D Potter
Different functional properties of troponin T mutants that cause dilated cardiomyopathy.
The Journal of biological chemistry 2003;278(43):41670-6.
2002: John M Robinson; Ying Wang; W Glenn L Kerrick; Ryoichi Kawai; Herbert C Cheung
Activation of striated muscle: nearest-neighbor regulatory-unit and cross-bridge influence on myofilament kinetics.
Journal of molecular biology 2002;322(5):1065-88.
2002: Ying Wang; W Glenn L Kerrick
The off rate of Ca(2+) from troponin C is regulated by force-generating cross bridges in skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(6):2409-18.
2001: Todd Miller; Danuta Szczesna-Cordary; Philippe R Housmans; Jiaju Zhao; F de Freitas; Aldrin Gomes; L Culbreath; J McCue; Ying Wang; Yuanyuan Xu; W Glenn L Kerrick; James D Potter
Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation.
The Journal of biological chemistry 2001;276(6):3743-55.
2000: K Allen; Y Y Xu; W Glenn L Kerrick
Ca(2+) measurements in skinned cardiac fibers: effects of Mg(2+) on Ca(2+) activation of force and fiber ATPase.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(1):180-5.
1999: Ying Wang; Yuanyuan Xu; K Guth; W Glenn L Kerrick
Troponin C regulates the rate constant for the dissociation of force-generating myosin cross-bridges in cardiac muscle.
Journal of muscle research and cell motility 1999;20(7):645-53.
1997: B Parsons; Danuta Szczesna-Cordary; Jiaju Zhao; G Van Slooten; W Glenn L Kerrick; John A Putkey; James D Potter
The effect of pH on the Ca2+ affinity of the Ca2+ regulatory sites of skeletal and cardiac troponin C in skinned muscle fibres.
Journal of muscle research and cell motility 1997;18(5):599-609.
1997: John A Putkey; Wen Liu; X Lin; S Ahmed; M Zhang; James D Potter; W Glenn L Kerrick
Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ.
Biochemistry 1997;36(4):970-8.
1994: W Glenn L Kerrick; P E Hoar
Relationship between ATPase activity, Ca2+, and force in alpha-toxin- and beta-escin-treated smooth muscle.
Canadian journal of physiology and pharmacology 1994;72(11):1361-7.
1993: Lilly Bouguignon; Vinata B Lokeshwar; X Chen; W Glenn L Kerrick
Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6634-44.
1993: V Pijuan; I Sukholutskaya; W Glenn L Kerrick; M Lam; C van Breemen; Irene Litosch
Rapid stimulation of Ins (1,4,5)P3 production in rat aorta by NE: correlation with contractile state.
The American journal of physiology 1993;264(1 Pt 2):H126-32.
1992: James D Potter; W Glenn L Kerrick
Wrongly citing literature.
Journal of muscle research and cell motility 1992;13(3):381-2.
1992: J E Parente; Michael P Walsh; W Glenn L Kerrick; P E Hoar
Effects of the constitutively active proteolytic fragment of protein kinase C on the contractile properties of demembranated smooth muscle fibres.
Journal of muscle research and cell motility 1992;13(1):90-9.
1991: Christopher C Ashley; T J Lea; P E Hoar; W Glenn L Kerrick; P F Strang; James D Potter
Functional characterization of the two isoforms of troponin C from the arthropod Balanus nubilus.
Journal of muscle research and cell motility 1991;12(6):532-42.
1991: W Glenn L Kerrick; James D Potter; P E Hoar
The apparent rate constant for the dissociation of force generating myosin crossbridges from actin decreases during Ca2+ activation of skinned muscle fibres.
Journal of muscle research and cell motility 1991;12(1):53-60.
1990: R E Kenney; P E Hoar; W Glenn L Kerrick
The relationship between ATPase activity, isometric force, and myosin light-chain phosphorylation and thiophosphorylation in skinned smooth muscle fiber bundles from chicken gizzard.
The Journal of biological chemistry 1990;265(15):8642-9.
1990: J E Parente; Michael P Walsh; W Glenn L Kerrick; P E Hoar
Effects of protein kinase-M on skinned smooth muscle fibres.
Progress in clinical and biological research 1990;327():149-57.
1990: W Glenn L Kerrick; R E Kenney; P E Hoar
Relationship between ATPase activity, isometric force, and myosin light chain phosphorylation and thiophosphorylation in skinned chicken gizzard fiber bundles.
Progress in clinical and biological research 1990;327():635-6.
1989: G Walker; W Glenn L Kerrick; Lilly Bouguignon
The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell.
The Journal of biological chemistry 1989;264(1):496-500.
1988: P E Hoar; W Glenn L Kerrick
Mn2+ activates skinned smooth muscle cells in the absence of myosin light chain phosphorylation.
Pflügers Archiv : European journal of physiology 1988;412(3):225-30.
1988: P E Hoar; James D Potter; W Glenn L Kerrick
Skinned ventricular fibres: troponin C extraction is species-dependent and its replacement with skeletal troponin C changes Sr2+ activation properties.
Journal of muscle research and cell motility 1988;9(2):165-73.
1987: P E Hoar; C W Mahoney; W Glenn L Kerrick
MgADP- increases maximum tension and Ca2+ sensitivity in skinned rabbit soleus fibers.
Pflügers Archiv : European journal of physiology 1987;410(1-2):30-6.
1987: W Glenn L Kerrick; P E Hoar
Non-Ca2+-activated contraction in smooth muscle.
Progress in clinical and biological research 1987;245():437-48.
1986: W Glenn L Kerrick; P E Hoar
Smooth muscle: regulation by calcium and phosphorylation.
Ciba Foundation symposium 1986;122():183-96.
1985: W Glenn L Kerrick; H G Zot; P E Hoar; James D Potter
Evidence that the Sr2+ activation properties of cardiac troponin C are altered when substituted into skinned skeletal muscle fibers.
The Journal of biological chemistry 1985;260(29):15687-93.
1985: P E Hoar; M D Pato; W Glenn L Kerrick
Myosin light chain phosphatase. Effect on the activation and relaxation of gizzard smooth muscle skinned fibers.
The Journal of biological chemistry 1985;260(15):8760-4.
1984: J Y Su; W Glenn L Kerrick; S A Hill
Effects of diethyl ether and nitrous oxide on functionally skinned myocardial cells of rabbits.
Anesthesia and analgesia 1984;63(4):451-6.
1984: W Glenn L Kerrick; Lilly Bouguignon
Regulation of receptor capping in mouse lymphoma T cells by Ca2+-activated myosin light chain kinase.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(1):165-9.
1983: M P Walsh; R Bridenbaugh; W Glenn L Kerrick; D J Hartshorne
Gizzard Ca2+-independent myosin light chain kinase: evidence in favor of the phosphorylation theory.
Federation proceedings 1983;42(1):45-50.
1983: Lilly Bouguignon; W Glenn L Kerrick
Receptor capping in mouse T-lymphoma cells: a Ca2+ and calmodulin-stimulated ATP-dependent process.
The Journal of membrane biology 1983;75(1):65-72.
1982: W Glenn L Kerrick; L L Bolles
Evidence that myosin light chain phosphorylation regulates contraction in the body wall muscles of the sea cucumber.
Journal of cellular physiology 1982;112(3):307-15.
1982: P Cassidy; W Glenn L Kerrick
Superprecipitation of gizzard actomyosin, and tension in gizzard muscle skinned fibers in the presence of nucleotides other than ATP.
Biochimica et biophysica acta 1982;705(1):63-9.
1982: M P Walsh; R Bridenbaugh; D J Hartshorne; W Glenn L Kerrick
Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.
The Journal of biological chemistry 1982;257(11):5987-90.
1982: D J Harshorne; M P Walsh; R Bridenbaugh; W Glenn L Kerrick
Regulation of the contractile apparatus in smooth muscle.
Proceedings of the Western Pharmacology Society 1982;25():339-41.
1981: W Glenn L Kerrick; L L Bolles
Regulation of Ca2+-activated tension in limulus striated muscle.
Pflügers Archiv : European journal of physiology 1981;392(2):121-4.
1981: P S Cassidy; W Glenn L Kerrick; P E Hoar; D A Malencik
Exogenous calmodulin increases Ca2+ sensitivity of isometric tension activation and myosin phosphorylation in skinned smooth muscle.
Pflügers Archiv : European journal of physiology 1981;392(2):115-20.
1981: W Glenn L Kerrick; P E Hoar
Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase.
Nature 1981;292(5820):253-5.
1981: W Glenn L Kerrick; P E Hoar; P S Cassidy; L Bolles; D A Malencik
Calcium-regulatory mechanisms. Functional classification using skinned fibers.
The Journal of general physiology 1981;77(2):177-90.
1980: P Cassidy; P E Hoar; W Glenn L Kerrick
Inhibition of Ca2+-activated tension and myosin light chain phosphorylation in skinned smooth muscle strips by the phenothiazines.
Pflügers Archiv : European journal of physiology 1980;387(2):115-20.
1980: W Glenn L Kerrick; D A Malencik; P E Hoar; James D Potter; R L Coby; S Pocinwong; Edmond H Fischer
Ca2+ and Sr2+ activation: comparison of cardiac and skeletal muscle contraction models.
Pflügers Archiv : European journal of physiology 1980;386(3):207-13.
1980: J Y Su; W Glenn L Kerrick
Effects of enflurane on functionally skinned myocardial fibers from rabbits.
Anesthesiology 1980;52(5):385-9.
1980: W Glenn L Kerrick; P E Hoar; P S Cassidy
Calcium-activated tension: the role of myosin light chain phosphorylation.
Federation proceedings 1980;39(5):1558-63.
1980: D J Secrist; W Glenn L Kerrick
Associated changes in Ca2+ and Sr2+ activation properties and fiber proteins in cross-reinnervated rabbit soleus.
Pflügers Archiv : European journal of physiology 1980;384(3):219-29.
1980: D L Brautigan; W Glenn L Kerrick; Edmond H Fischer
Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(2):936-9.
1980: P K Bhagat; W Glenn L Kerrick; R W Ware
Ultrasonic characterization of aging in skin tissue.
Ultrasound in medicine & biology 1980;6(4):369-75.
1979: P S Cassidy; W Glenn L Kerrick
Enzymatic preparation of adenosine 5'-O-(3-[35S]thiotriphosphate) by thiophosphorylation of adenosine diphosphate.
Biochimica et biophysica acta 1979;565(1):209-13.
1979: P Cassidy; P E Hoar; W Glenn L Kerrick
Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S]ATP gamma S.
The Journal of biological chemistry 1979;254(21):11148-53.
1979: P E Hoar; W Glenn L Kerrick
Rabbit diaphragm: two types of fibres determined by calcium strontium activation and protein content.
The Journal of physiology 1979;295():345-52.
1979: W Glenn L Kerrick; P E Hoar; D A Malencik; L Stamps; Edmond H Fischer
Characterization of Ca2+- and Sr2+-activated tension in functionally skinned chicken fibers of normal and dystrophic skeletal and normal cardiac muscle.
Pflügers Archiv : European journal of physiology 1979;381(1):53-62.
1979: J Y Su; W Glenn L Kerrick
Effects of halothane on caffeine-induced tension transients in functionally skinned myocardial fibers.
Pflügers Archiv : European journal of physiology 1979;380(1):29-34.
1979: S P Robertson; W Glenn L Kerrick
The effects of pH on Ca2+-activated force in frog skeletal muscle fibers.
Pflügers Archiv : European journal of physiology 1979;380(1):41-5.
1979: P E Hoar; W Glenn L Kerrick; P S Cassidy
Chicken gizzard: relation between calcium-activated phosphorylation and contraction.
Science (New York, N.Y.) 1979;204(4392):503-6.
1979: H J Moeschler; D A Malencik; S Pocinwong; O Alaba; W Glenn L Kerrick; Edmond H Fischer
Exchange of calcium between muscle Ca2+-binding proteins.
Biochimie 1979;61(5-6):615-24.
1978: J Y Su; W Glenn L Kerrick
Effects of halothane on Ca2+-activated tension development in mechanically disrupted rabbit myocardial fibers.
Pflügers Archiv : European journal of physiology 1978;375(2):111-7.
1978: S K Donaldson; Philip M Best; W Glenn L Kerrick
Characterization of the effects of Mg2+ on Ca2+- and Sr2+-activated tension generation of skinned rat cardiac fibers.
The Journal of general physiology 1978;71(6):645-55.
1977: Philip M Best; S K Donaldson; W Glenn L Kerrick
Tension in mechanically disrupted mammalian cardiac cells: effects of magnesium adenosine triphosphate.
The Journal of physiology 1977;265(1):1-17.
1976: W Glenn L Kerrick; D Secrist; R Coby; S Lucas
Development of difference between red and white muscles in sensitivity to Ca2+ in the rabbit from embryo to adult.
Nature 1976;260(5550):440-1.
1975: W Glenn L Kerrick; B Krasner
Disruption of the sarcolemma of mammalian skeletal muscle fibers by homogenization.
Journal of applied physiology 1975;39(6):1052-5.
1975: S K Donaldson; W Glenn L Kerrick
Characterization of the effects of Mg2+ on Ca2+- and Sr2+-activated tension generation of skinned skeletal muscle fibers.
The Journal of general physiology 1975;66(4):427-44.
1975: W Glenn; W Glenn L Kerrick; S K Donaldson
The comparative effects of (Ca2+) and (Mg2+) on on tension generation in the fibers of skinned frog skeletal muscle and mechanically disrupted rat ventricular cardiac muscle.
Pflügers Archiv : European journal of physiology 1975;358(3):195-201.
1974: W Glenn L Kerrick; Philip M Best
Calcium ion release in mechanically disrupted heart cells.
Science (New York, N.Y.) 1974;183(4123):435-7.
1972: W Glenn L Kerrick; S K Donaldson
The effects of Mg 2+ on submaximum Ca 2+ -activated tension in skinned fibers of frog skeletal muscle.
Biochimica et biophysica acta 1972;275(1):117-22.
1971: A M Scher; W W Ohm; W Glenn L Kerrick; S M Lewis; A C Young
Effects of body surface boundary and of tissue inhomogeneity on the electrocardiogram of the dog.
Circulation research 1971;29(6):600-9.