FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Benedikt Kessler

Research Profile

Chemicals & Drugs

Procedures

Concepts & Ideas

Phenomena

Physiology

Post Translational Protein Processing

Anatomy

Hela Cells

Co-author Network

Publications

TOP 3
Min Lu; Mark R Middleton; Indrika Ratnayaka; Victoria Salter; Christian Siebold; Alex Sullivan; Elena V Sviderskaya; Shan Zhong; Caroline Baer; Hilde Breyssens; Nick R Brown; Otavia L Caballero; Jonathan Cebon; Jane Endicott; Colin R Goding; Ying Hu; Thomas John; E Yvonne Jones; Benedikt M Kessler; Stefan Knapp; Xin Lu
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
Andrew J M Howden; Kristin Katsch; Benedikt M Kessler; Benjamin Thomas; David C Trudgian; Bhaskar Bhushan; Omar Boutureira; Benjamin G Davis; Daniela C Dieterich; Georgios Efstathiou; Vincent Geoghegan; Oreste Acuto
QuaNCAT: quantitating proteome dynamics in primary cells.
Nicola Ternette; Kathryn Wolhulter; Ming Yang; Kaori Saito; Tomoyoshi Soga; Julie Adam; Alexandre Berquand; Roman Fischer; Norma Frizzell; Kaori Igarashi; Keiko Kato; Benedikt M Kessler; Mitsuhiro Kitagawa; Terry Lappin; Mahima Laroyia; Linda O'Flaherty; Patrick J Pollard
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Benedikt Kessler (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Min Lu; Mark R Middleton; Indrika Ratnayaka; Victoria Salter; Christian Siebold; Alex Sullivan; Elena V Sviderskaya; Shan Zhong; Caroline Baer; Hilde Breyssens; Nick R Brown; Otavia L Caballero; Jonathan Cebon; Jane Endicott; Colin R Goding; Ying Hu; Thomas John; E Yvonne Jones; Benedikt M Kessler; Stefan Knapp; Xin Lu
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
Cancer cell 2013;23(5):618-33.
2013: Andrew J M Howden; Kristin Katsch; Benedikt M Kessler; Benjamin Thomas; David C Trudgian; Bhaskar Bhushan; Omar Boutureira; Benjamin G Davis; Daniela C Dieterich; Georgios Efstathiou; Vincent Geoghegan; Oreste Acuto
QuaNCAT: quantitating proteome dynamics in primary cells.
Nature methods 2013;10(4):343-6.
2013: Nicola Ternette; Kathryn Wolhulter; Ming Yang; Kaori Saito; Tomoyoshi Soga; Julie Adam; Alexandre Berquand; Roman Fischer; Norma Frizzell; Kaori Igarashi; Keiko Kato; Benedikt M Kessler; Mitsuhiro Kitagawa; Terry Lappin; Mahima Laroyia; Linda O'Flaherty; Patrick J Pollard
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
Cell reports 2013;3(3):689-700.
2013: Marie L Thézénas; Michael Walther; David J Conway; katalin di gleria; Roman Fischer; Honglei Huang; Benedikt M Kessler; Madi Njie; Davis Nwakanma; Abhinay Ramaprasad; Climent Casals-Pascual
PfHPRT: a new biomarker candidate of acute Plasmodium falciparum infection.
Journal of proteome research 2013;12(3):1211-22.
2013: Benedikt M Kessler
Ubiquitin - omics reveals novel networks and associations with human disease.
Current opinion in chemical biology 2013;17(1):59-65.
2012: Davor Frleta; Barton F Haynes; Benedikt M Kessler; Shaukat Ali Khan; Holger B Kramer; Carolyn E Ochoa; Andrea R Stacey; Persephone Borrow; Nina Bhardwaj
HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.
The Journal of clinical investigation 2012;122(12):4685-97.
2012: Jason L Parsons; Nicola Ternette; Pran K Datta; Irina I Dianova; Benedikt M Kessler; Svetlana V Khoronenkova; Grigory L Dianov
Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.
Nucleic acids research 2012;40(22):11404-15.
2012: Holger B Kramer; Benjamin Nicholson; Benedikt M Kessler; Mikael Altun
Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development.
Biochimica et biophysica acta 2012;1823(11):2029-37.
2012: Dharminder Chauhan; Mariaterresa Fulcinniti; Teru Hideshima; Benedikt M Kessler; William D Kingsbury; Matthew P Kodrasov; K G Suresh Kumar; Craig A Leach; Jeffrey L McDermott; Stephane Minvielle; Nikhil Munshi; Benjamin Nicholson; Robert Orlowski; Paul Richardson; Parantu K Shah; Ze Tian; Joseph Weinstock; Bin Zhou; Mikael Altun; Ruben Carrasco; Kenneth C Anderson
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Cancer cell 2012;22(3):345-58.
2012: Alexander Iphöfer; Lothar Jänsch; Benedikt M Kessler; Anne Kummer; Manfred Nimtz; Antje Ritter; Joop van den Heuvel; Tatjana Arnold; Ronald Frank; Raimo Franke
Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.
Chembiochem : a European journal of chemical biology 2012;13(10):1416-20.
2012: Joanna F McGouran; Mikael Altun; katalin di gleria; Holger B Kramer; Mukram M Mackeen; Benedikt M Kessler
Fluorescence-based active site probes for profiling deubiquitinating enzymes.
Organic & biomolecular chemistry 2012;10(17):3379-83.
2012: Svetlana V Khoronenkova; Jason L Parsons; Nicola Ternette; Irina I Dianova; Benedikt M Kessler; Grigory L Dianov
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
Molecular cell 2012;45(6):801-13.
2012: Norma Masson; Melroy X Miranda; Lucy J Ambrose; Benedikt M Kessler; Christopher J Schofield; Rok Sekirnik; Rachelle S Singleton; Ya-Min Tian; David C Trudgian; Peter J Ratcliffe
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
EMBO reports 2012;13(3):251-7.
2012: Roman Fischer; Paul Bowness; Linda A Bradbury; Matthew A Brown; Gethin Thomas; David C Trudgian; Cynthia Wright; Benedikt M Kessler
Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis.
Molecular & cellular proteomics : MCP 2012;11(2):M111.013904.
2012: Despoina A I Mavridou; Leonie Mönkemeyer; Julie M Stevens; Oliver Daltrop; katalin di gleria; Stuart J Ferguson; Benedikt M Kessler; James W A Allen
A pivotal heme-transfer reaction intermediate in cytochrome c biogenesis.
The Journal of biological chemistry 2012;287(4):2342-52.
2012: Anca M Farcas; Benedikt M Kessler; Neil P Blackledge; Neil Brockdorff; Andrea Cerase; Haruhiko Koseki; Sheena Lee; Hannah K Long; Joanna F McGouran; Chris P Ponting; Nathan R Rose; Thomas W Sheahan; David Sims; Ian Sudbery; Robert J Klose
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.
eLife 2012;1():e00205.
2012: Honglei Huang; Benedikt M Kessler; Emily Locke; Mukram M Mackeen; Davis Nwakanma; Eniyou Oriero; Marie L Thézénas; Matthew Cook; Climent Casals-Pascual
Proteomic identification of host and parasite biomarkers in saliva from patients with uncomplicated Plasmodium falciparum malaria.
Malaria journal 2012;11():178.
2012: Rebecca Konietzny; Nicola Ternette; Benjamin W Turney; Cynthia A Wright; Aron Chakera; Roman Fischer; David Hughes; Benedikt M Kessler; Chris W Pugh
Detection of BK virus in urine from renal transplant subjects by mass spectrometry.
Clinical proteomics 2012;9(1):4.
2012: Cornelia Meisenberg; Jason L Parsons; Phillip S Tait; Takafumi Tasaki; Nicola Ternette; Katherine Wright; Irina I Dianova; Mariola J Edelmann; Benedikt M Kessler; Yong Tae Kwon; Grigory L Dianov
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
Nucleic acids research 2012;40(2):701-11.
2011: Mikael Altun; Grigory L Dianov; Roman Fischer; Seth J Goldenberg; Svetlana V Khoronenkova; Edward Kogan; Rebecca Konietzny; Holger B Kramer; K G Suresh Kumar; Craig A Leach; Mukram M Mackeen; Jeffrey L McDermott; Joanna McGouran; Benjamin Nicholson; Jason L Parsons; Lianne I Willems; Benedikt M Kessler
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Chemistry & biology 2011;18(11):1401-12.
2011: Julie Adam; Dilair Baban; Peter Carmeliet; Mona El-Bahrawy; Roman Fischer; Norma Frizzell; Emine Hatipoglu; Benedikt M Kessler; Helen Lockstone; Patrick H Maxwell; Emma Nye; Linda O'Flaherty; Christopher W Pugh; Peter J Ratcliffe; Natasha Sahgal; Tomoyoshi Soga; Gordon W Stamp; Marcus Stevens; Nicola Ternette; Kathryn Wolhuter; Patrick J Pollard
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Cancer cell 2011;20(4):524-37.
2011: Rachelle S Singleton; David C Trudgian; Roman Fischer; Benedikt M Kessler; Peter J Ratcliffe; Matthew E Cockman
Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
The Journal of biological chemistry 2011;286(39):33784-94.
2011: C A Wright; F C Hamdy; S Howles; Benedikt M Kessler; Jeremy G Noble; John M Reynard; D C Trudgian; Benjamin W Turney
Label-free quantitative proteomics reveals differentially regulated proteins influencing urolithiasis.
Molecular & cellular proteomics : MCP 2011;10(8):M110.005686.
2011: Rasheduzzaman Chowdhury; Ian J Clifton; Emily Flashman; Yves-Michel Frapart; Benedikt M Kessler; Holger B Kramer; Michael McDonough; Jasmin Mecinović; Jean-Luc Boucher; Christopher J Schofield
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
Journal of molecular biology 2011;410(2):268-79.
2011: David C Trudgian; Oreste Acuto; Roman Fischer; Benedikt M Kessler; Mukram M Mackeen; Gabriela Ridlova; Nicola Ternette; Benjamin Thomas
Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline.
Proteomics 2011;11(14):2790-7.
2011: Benedikt M Kessler; Mariola J Edelmann
PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.
Cell biochemistry and biophysics 2011;60(1-2):21-38.
2011: dante rotili; Mikael Altun; Akane Kawamura; Alexander Wolf; Roman Fischer; Ivanhoe K H Leung; Mukram M Mackeen; Ya-Min Tian; Peter J Ratcliffe; Antonello Mai; Benedikt M Kessler; Christopher J Schofield
A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.
Chemistry & biology 2011;18(5):642-54.
2011: Grazyna Kochan; Tobias Krojer; David Harvey; Roman Fischer; Liye Chen; Melanie Vollmar; Frank von Delft; Kathryn L Kavanagh; Matthew A Brown; Paul Bowness; Paul Wordsworth; Benedikt M Kessler; Udo Oppermann
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7745-50.
2011: Srinika R F Ranasinghe; Holger B Kramer; Cynthia Wright; Benedikt M Kessler; katalin di gleria; Yonghong Zhang; Geraldine M A Gillespie; Marie-Eve Blais; Abigail Culshaw; Tica Pichulik; Alison Simmons; Sarah L Rowland-Jones; Andrew J McMichael; Tao Dong
The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.
PLoS pathogens 2011;7(5):e1001341.
2011: Ya-Min Tian; Kar Kheng Yeoh; Myung Kyu Lee; Tuula Eriksson; Benedikt M Kessler; Holger B Kramer; Mariola J Edelmann; Carsten Willam; Christopher W Pugh; Christopher J Schofield; Peter J Ratcliffe
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
The Journal of biological chemistry 2011;286(15):13041-51.
2011: Ming Yang; Rasheduzzaman Chowdhury; Wei Ge; Refaat B Hamed; Michael McDonough; Timothy D W Claridge; Benedikt M Kessler; Matthew E Cockman; Peter J Ratcliffe; Christopher J Schofield
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
The FEBS journal 2011;278(7):1086-97.
2011: Muna M El-Kasti; Cynthia Wright; Haddy K S Fye; Fenella Roseman; Benedikt M Kessler; Christian M Becker
Urinary peptide profiling identifies a panel of putative biomarkers for diagnosing and staging endometriosis.
Fertility and sterility 2011;95(4):1261-6.e1-6.
2011: Jason L Parsons; Irina I Dianova; Svetlana V Khoronenkova; Mariola J Edelmann; Benedikt M Kessler; Grigory L Dianov
USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
Molecular cell 2011;41(5):609-15.
2011: Ming Yang; Wei Ge; Rasheduzzaman Chowdhury; Timothy D W Claridge; Holger B Kramer; Bernhard Schmierer; Michael A McDonough; Lingzhi Gong; Benedikt M Kessler; Peter J Ratcliffe; Mathew L Coleman; Christopher J Schofield
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
The Journal of biological chemistry 2011;286(9):7648-60.
2011: dante rotili; Mikael Altun; Refaat B Hamed; Christoph Loenarz; Armin Thalhammer; Richard J Hopkinson; Ya-Min Tian; Peter J Ratcliffe; Antonello Mai; Benedikt M Kessler; Christopher J Schofield
Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions.
Chemical communications (Cambridge, England) 2011;47(5):1488-90.
2011: Mariola J Edelmann; Benjamin Nicholson; Benedikt M Kessler
Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.
Expert reviews in molecular medicine 2011;13():e35.
2011: Mattias Vesterlund; Fahad Zadjali; Benedikt M Kessler; Michael Lund Nielsen; Gunnar Norstedt; Torbjörn Persson; Amilcar Flores-Morales
The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
PloS one 2011;6(9):e25358.
2011: Edward J Andress; Mariola J Edelmann; Roman Holic; Benedikt M Kessler; Veronica P C C Yu
Dia2 controls transcription by mediating assembly of the RSC complex.
PloS one 2011;6(6):e21172.
2010: Paul P Geurink; Bogdan I Florea; Gijs A Van der Marel; Benedikt M Kessler; Herman S Overkleeft
Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates.
Chemical communications (Cambridge, England) 2010;46(47):9052-4.
2010: Mikael Altun; Henrike C Besche; Herman S Overkleeft; Rosanna Piccirillo; Mariola J Edelmann; Benedikt M Kessler; Alfred L Goldberg; Brun Ulfhake
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.
The Journal of biological chemistry 2010;285(51):39597-608.
2010: Joanna L Fox; Ferina Ismail; Abul Azad; Nicola Ternette; Sabrina Leverrier; Mariola J Edelmann; Benedikt M Kessler; Irene M Leigh; Sarah Jackson; Alan Storey
Tyrosine dephosphorylation is required for Bak activation in apoptosis.
The EMBO journal 2010;29(22):3853-68.
2010: Danmei Xu; Chad M McKee; Yunhong Cao; Yunchuan Ding; Benedikt M Kessler; Ruth J Muschel
Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1.
Cancer research 2010;70(17):6988-98.
2010: Mukram M Mackeen; Holger B Kramer; Kai-Hsuan Chang; Matthew L Coleman; Richard J Hopkinson; Christopher J Schofield; Benedikt M Kessler
Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry.
Journal of proteome research 2010;9(8):4082-92.
2010: Roman Holic; Alexander Kukalev; Sophie Lane; Edward J Andress; Ivy Lau; Conny W H Yu; Mariola J Edelmann; Benedikt M Kessler; Veronica P C C Yu
Cks1 activates transcription by binding to the ubiquitylated proteasome.
Molecular and cellular biology 2010;30(15):3894-901.
2010: Mariola J Edelmann; Holger B Kramer; Mikael Altun; Benedikt M Kessler
Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
The FEBS journal 2010;277(11):2515-30.
2010: Holger B Kramer; Kerry J Lavender; Li Qin; Andrea R Stacey; Michael K P Liu; katalin di gleria; Alison Simmons; Nancy Gasper-Smith; Barton F Haynes; Andrew J McMichael; Persephone Borrow; Benedikt M Kessler
Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.
PLoS pathogens 2010;6(5):e1000893.
2010: David C Trudgian; Benjamin Thomas; Simon J McGowan; Benedikt M Kessler; Mogjiborahman Salek; Oreste Acuto
CPFP: a central proteomics facilities pipeline.
Bioinformatics (Oxford, England) 2010;26(8):1131-2.
2010: Daniele V F Tauriello; Andrea Haegebarth; Ineke Kuper; Mariola J Edelmann; Marre Henraat; Marijke R Canninga-Van Dijk; Benedikt M Kessler; Hans Clevers; Madelon M Maurice
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Molecular cell 2010;37(5):607-19.
2010: Benedikt M Kessler
Challenges ahead for mass spectrometry and proteomics applications in epigenetics.
Epigenomics 2010;2(1):163-7.
2010: Meftun Ahmed; Matt J Neville; Mariola J Edelmann; Benedikt M Kessler; Fredrik Karpe
Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake.
Obesity (Silver Spring, Md.) 2010;18(1):27-34.
2009: Jason L Parsons; Phillip S Tait; David Finch; Irina I Dianova; Mariola J Edelmann; Svetlana V Khoronenkova; Benedikt M Kessler; Ricky A Sharma; W Gillies McKenna; Grigory L Dianov
Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
The EMBO journal 2009;28(20):3207-15.
2009: Frank Sobott; Stephen J Watt; Julia Smith; Mariola J Edelmann; Holger B Kramer; Benedikt M Kessler
Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.
Journal of the American Society for Mass Spectrometry 2009;20(9):1652-9.
2009: Mariola J Edelmann; Alexander Iphöfer; Masato Akutsu; Mikael Altun; katalin di gleria; Holger B Kramer; Edda Fiebiger; Sirano Dhe-Paganon; Benedikt M Kessler
Structural basis and specificity of human otubain 1-mediated deubiquitination.
The Biochemical journal 2009;418(2):379-90.
2009: Matthew E Cockman; James D Webb; Holger B Kramer; Benedikt M Kessler; Peter J Ratcliffe
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
Molecular & cellular proteomics : MCP 2009;8(3):535-46.
2008: Mariola J Edelmann; Benedikt M Kessler
Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles.
Biochimica et biophysica acta 2008;1782(12):809-16.
2008: Danmei Xu; Naoko Suenaga; Mariola J Edelmann; Rafael Fridman; Ruth J Muschel; Benedikt M Kessler
Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach.
Molecular & cellular proteomics : MCP 2008;7(11):2215-28.
2008: Muhammad Emaduddin; Mariola J Edelmann; Benedikt M Kessler; Stephan M Feller
Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells.
Cell communication and signaling : CCS 2008;6():7.
2007: Benedikt M Kessler; Elisabetta Fortunati; Monique Melis; Cornelieke E G M Pals; Hans Clevers; Madelon M Maurice
Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.
Journal of proteome research 2007;6(11):4163-72.
2007: Mathew L Coleman; Michael McDonough; Kirsty S Hewitson; Charlotte Coles; Jasmin Mecinovic; Mariola Edelmann; Kristina M Cook; Matthew E Cockman; David E Lancaster; Benedikt M Kessler; Neil J Oldham; Peter J Ratcliffe; Christopher J Schofield
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
The Journal of biological chemistry 2007;282(33):24027-38.
2007: Mikael Altun; Erik Edström; Eric Spooner; Amilcar Flores-Morales; Esbjörn Bergman; Petra Tollet-Egnell; Gunnar Norstedt; Benedikt M Kessler; Brun Ulfhake
Iron load and redox stress in skeletal muscle of aged rats.
Muscle & nerve 2007;36(2):223-33.
2007: Paul F van Swieten; Emlyn Samuel; Rosa Orient Hernández; Adrianus M C H van den Nieuwendijk; Michiel A Leeuwenburgh; Gijsbert A van der Marel; Benedikt M Kessler; Herman S Overkleeft; Alexei F Kisselev
A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.
Bioorganic & medicinal chemistry letters 2007;17(12):3402-5.
2006: Benedikt M Kessler
Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes.
Expert review of proteomics 2006;3(2):213-21.
2006: Mariola Batycka; Neil F Inglis; Ken Cook; Alex Adam; Douglas Fraser-Pitt; David G E Smith; Laura Main; Anneke Lubben; Benedikt M Kessler
Ultra-fast tandem mass spectrometry scanning combined with monolithic column liquid chromatography increases throughput in proteomic analysis.
Rapid communications in mass spectrometry : RCM 2006;20(14):2074-80.
2005: Mikael Altun; Paul J Galardy; Reshma Shringarpure; Teru Hideshima; Richard LeBlanc; Kenneth C Anderson; Hidde L Ploegh; Benedikt M Kessler
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells.
Cancer research 2005;65(17):7896-901.
2005: Lisa M Kattenhorn; Gregory A Korbel; Benedikt M Kessler; Eric Spooner; Hidde L Ploegh
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae.
Molecular cell 2005;19(4):547-57.
2005: Celia R Berkers; Martijn Verdoes; Eben Lichtman; Edda Fiebiger; Benedikt M Kessler; Kenneth C Anderson; Hidde L Ploegh; Huib Ovaa; Paul J Galardy
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib.
Nature methods 2005;2(5):357-62.
2005: Anna Borodovsky; Huib Ovaa; Wim J N Meester; Emily Venanzi; Matthew Bogyo; Brian G Hekking; Hidde L Ploegh; Benedikt M Kessler; Herman S Overkleeft
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.
Chembiochem : a European journal of chemical biology 2005;6(2):287-91.
2005: Paul F van Swieten; Michiel A Leeuwenburgh; Benedikt M Kessler; Herman S Overkleeft
Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules.
Organic & biomolecular chemistry 2005;3(1):20-7.
2004: Jana Kadlcíková; Milan Holecek; Roman Safránek; Ivan Tilser; Benedikt M Kessler
Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats.
International journal of experimental pathology 2004;85(6):365-71.
2004: Xin Ye; Grzegorz Nalepa; Markus Welcker; Benedikt M Kessler; Eric Spooner; Jun Qin; Stephen J Elledge; Bruce E Clurman; J Wade Harper
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.
The Journal of biological chemistry 2004;279(48):50110-9.
2004: Lisa M Kattenhorn; Ryan Mills; Markus Wagner; Alexandre Lomsadze; Vsevolod Makeev; Mark Borodovsky; Hidde L Ploegh; Benedikt M Kessler
Identification of proteins associated with murine cytomegalovirus virions.
Journal of virology 2004;78(20):11187-97.
2004: Paul F van Swieten; Rene Maehr; Adrianus M C H van den Nieuwendijk; Benedikt M Kessler; Michael Reich; Chung-Sing Wong; Hubert Kalbacher; Michiel A Leeuwenburgh; Christoph Driessen; Gijsbert A van der Marel; Hidde L Ploegh; Herman S Overkleeft
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.
Bioorganic & medicinal chemistry letters 2004;14(12):3131-4.
2004: Haim Y Cohen; Siva Lavu; Kevin J Bitterman; Brian Hekking; Thomas A Imahiyerobo; Christine Miller; Roy Frye; Hidde L Ploegh; Benedikt M Kessler; David A Sinclair
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Molecular cell 2004;13(5):627-38.
2004: Joris Hemelaar; Paul J Galardy; Anna Borodovsky; Benedikt M Kessler; Hidde L Ploegh; Huib Ovaa
Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases.
Journal of proteome research 2004;3(2):268-76.
2004: Huib Ovaa; Benedikt M Kessler; Ulrika Rolén; Paul J Galardy; Hidde L Ploegh; Maria Masucci
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2253-8.
2004: Joris Hemelaar; Anna Borodovsky; Benedikt M Kessler; David Reverter; Julie Cook; Nagamalleswari Kolli; Tudeviin Gan-Erdene; Keith Wilkinson; Grace Gill; Christopher D Lima; Hidde L Ploegh; Huib Ovaa
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.
Molecular and cellular biology 2004;24(1):84-95.
2003: Joris Hemelaar; Victor S Lelyveld; Benedikt M Kessler; Hidde L Ploegh
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L.
The Journal of biological chemistry 2003;278(51):51841-50.
2003: Christine Kocks; Rene Maehr; Herman S Overkleeft; Evelyn W Wang; Lackshmanan K Iyer; Ana-Maria Lennon-Dumenil; Hidde L Ploegh; Benedikt M Kessler
Functional proteomics of the active cysteine protease content in Drosophila S2 cells.
Molecular & cellular proteomics : MCP 2003;2(11):1188-97.
2003: Huib Ovaa; Paul F van Swieten; Benedikt M Kessler; Michiel A Leeuwenburgh; Edda Fiebiger; Adrianus M C H van den Nieuwendijk; Paul J Galardy; Gijsbert A van der Marel; Hidde L Ploegh; Herman S Overkleeft
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy.
Angewandte Chemie (International ed. in English) 2003;42(31):3626-9.
2003: Ae-Ran Kwon; Benedikt M Kessler; Herman S Overkleeft; David B McKay
Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome.
Journal of molecular biology 2003;330(2):185-95.
2002: Anna Borodovsky; Huib Ovaa; Nagamalleswari Kolli; Tudeviin Gan-Erdene; Keith Wilkinson; Hidde L Ploegh; Benedikt M Kessler
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
Chemistry & biology 2002;9(10):1149-59.
2002: Benedikt M Kessler; Rickard Glas; Hidde L Ploegh
MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation.
Molecular immunology 2002;39(3-4):171-9.
2002: Marcelo C Sousa; Benedikt M Kessler; Herman S Overkleeft; David B McKay
Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU.
Journal of molecular biology 2002;318(3):779-85.
2001: Anna Borodovsky; Benedikt M Kessler; R Casagrande; Herman S Overkleeft; Keith Wilkinson; Hidde L Ploegh
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.
The EMBO journal 2001;20(18):5187-96.
2001: Benedikt M Kessler; Domenico Tortorella; Mikael Altun; Alexei F Kisselev; Edda Fiebiger; Brian Hekking; Hidde L Ploegh; Herman S Overkleeft
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
Chemistry & biology 2001;8(9):913-29.
2000: Evelyn W Wang; Benedikt M Kessler; Anna Borodovsky; Benjamin F Cravatt; Matthew Bogyo; Hidde L Ploegh; Rickard Glas
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9990-5.