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Horst Kessler

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Florian Rechenmacher; Joachim P Spatz; Carlos Mas-Moruno; Stefanie Neubauer; Julien Polleux; Elisabetta Ada Cavalcanti-Adam; Mariarosaria De Simone; Reinhard Fässler; Horst Kessler
Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro.
Marco Retzlaff; Julia Rohrberg; Alexander Bepperling; Horst Kessler; Natascha Jennifer Küpper; Stephan Lagleder; Florian Manzenrieder; Jirka Peschek; Johannes Buchner
The regulatory domain stabilizes the p53 tetramer by intersubunit contacts with the DNA binding domain.
Iina Laitinen; Stephan G Nekolla; Stefanie Neubauer; Johannes Notni; Karolin Pohle; Martina Rudelius; Eliane Farrell; Gjermund Henriksen; Horst Kessler; Hans-Jürgen Wester; Markus Schwaiger
Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction.

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All Publications

2013: Florian Rechenmacher; Joachim P Spatz; Carlos Mas-Moruno; Stefanie Neubauer; Julien Polleux; Elisabetta Ada Cavalcanti-Adam; Mariarosaria De Simone; Reinhard Fässler; Horst Kessler
Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro.
Angewandte Chemie (International ed. in English) 2013;52(5):1572-5.
2013: Marco Retzlaff; Julia Rohrberg; Alexander Bepperling; Horst Kessler; Natascha Jennifer Küpper; Stephan Lagleder; Florian Manzenrieder; Jirka Peschek; Johannes Buchner
The regulatory domain stabilizes the p53 tetramer by intersubunit contacts with the DNA binding domain.
Journal of molecular biology 2013;425(1):144-55.
2013: Iina Laitinen; Stephan G Nekolla; Stefanie Neubauer; Johannes Notni; Karolin Pohle; Martina Rudelius; Eliane Farrell; Gjermund Henriksen; Horst Kessler; Hans-Jürgen Wester; Markus Schwaiger
Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction.
EJNMMI research 2013;3(1):38.
2013: Carlos Mas-Moruno; Stefanie Neubauer; Ute Reuning; Rainer Burgkart; Petra M Dorfner; Florian Manzenrieder; Horst Kessler
Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides.
Journal of biomedical materials research. Part A 2013;101(1):87-97.
2012: Oliver Demmer; Andreas O Frank; Franz Hagn; Stephan Kremb; Luciana Marinelli; Margret Schottelius; Hans-Jürgen Wester; Ruth Brack-Werner; Sandro Cosconati; Horst Kessler
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity.
Angewandte Chemie (International ed. in English) 2012;51(32):8110-3.
2012: Karolin Pohle; Markus Schwaiger; Johanna Bussemer; Horst Kessler; Johannes Notni; Ambros J Beer
68Ga-NODAGA-RGD is a suitable substitute for (18)F-Galacto-RGD and can be produced with high specific activity in a cGMP/GRP compliant automated process.
Nuclear medicine and biology 2012;39(6):777-84.
2012: Johannes G Beck; Jayanta Chatterjee; Andreas O Frank; Chaim Gilon; Sarit Greenberg; Amnon Hoffman; Marelli Udaya Kiran; Burkhardt Laufer; Stefanie Neubauer; Oded Ovadia; Horst Kessler
Intestinal permeability of cyclic peptides: common key backbone motifs identified.
Journal of the American Chemical Society 2012;134(29):12125-33.
2012: Jochen Spiegel; Carlos Mas-Moruno; Horst Kessler; William D Lubell
Cyclic aza-peptide integrin ligand synthesis and biological activity.
The Journal of organic chemistry 2012;77(12):5271-8.
2012: Andreas B Schmid; Sebastian K Wandinger; Marc B Cox; Oliver Demmer; Melissa Ann Gräwert; Michael Groll; Franz Hagn; Horst Kessler; Stephan Lagleder; Klaus Richter; Alina Röhl; Johannes Buchner
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
The EMBO journal 2012;31(6):1506-17.
2012: Jayanta Chatterjee; Burkhardt Laufer; Horst Kessler
Synthesis of N-methylated cyclic peptides.
Nature protocols 2012;7(3):432-44.
2012: Florian C Gaertner; Horst Kessler; Markus Schwaiger; Hans-Jürgen Wester; Ambros J Beer
Radiolabelled RGD peptides for imaging and therapy.
European journal of nuclear medicine and molecular imaging 2012;39 Suppl 1():S126-38.
2012: Markus Bollinger; Joseph Fanous; Amnon Hoffman; Alexander Bochen; Roman Kolb; Vittorio Limongelli; Wolfgang Lindner; Florian Manzenrieder; Luciana Marinelli; G Moessmer; Stefanie Neubauer; Ettore Novellino; Reinhard Pell; Horst Kessler
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site.
Journal of medicinal chemistry 2012;55(2):871-82.
2011: Oliver Demmer; Ingrid Dijkgraaf; Eleni Gourni; Luciana Marinelli; Udo Schumacher; Hans-Jürgen Wester; Sandro Cosconati; Horst Kessler
Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.
Journal of medicinal chemistry 2011;54(21):7648-62.
2011: Eleni Gourni; Horst Kessler; Margret Schottelius; Stefan Schulz; Udo Schumacher; Markus Schwaiger; Calogero D'Alessandria; Oliver Demmer; Ingrid Dijkgraaf; Hans-Jürgen Wester
PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(11):1803-10.
2011: Oliver Demmer; Eleni Gourni; Horst Kessler; Udo Schumacher; Hans-Jürgen Wester
PET imaging of CXCR4 receptors in cancer by a new optimized ligand.
ChemMedChem 2011;6(10):1789-91.
2011: Carlos Mas-Moruno; Ettore Novellino; Luciana Marinelli; Johannes G Beck; Sandro Cosconati; Lucas Doedens; Andreas O Frank; Horst Kessler
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.
Angewandte Chemie (International ed. in English) 2011;50(40):9496-500.
2011: Thomas A Knappe; Uwe Linne; Florian Manzenrieder; Carlos Mas-Moruno; Florenz Sasse; Xiulan Xie; Horst Kessler; Mohamed A Marahiel
Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.
Angewandte Chemie (International ed. in English) 2011;50(37):8714-7.
2011: Janosch A Deeg; Ilia Louban; Daniel Aydin; Christine Selhuber-Unkel; Horst Kessler; Joachim P Spatz
Impact of local versus global ligand density on cellular adhesion.
Nano letters 2011;11(4):1469-76.
2011: Franz Hagn; Christopher Thamm; Thomas Scheibel; Horst Kessler
pH-dependent dimerization and salt-dependent stabilization of the N-terminal domain of spider dragline silk--implications for fiber formation.
Angewandte Chemie (International ed. in English) 2011;50(1):310-3.
2011: Ambros J Beer; Horst Kessler; Hans-Jürgen Wester; Markus Schwaiger
PET Imaging of Integrin αVβ3 Expression.
Theranostics 2011;1():48-57.
2010: Sebastian Kruss; Tobias Wolfram; Raquel Martin; Stefanie Neubauer; Horst Kessler; Joachim P Spatz
Stimulation of cell adhesion at nanostructured teflon interfaces.
Advanced materials (Deerfield Beach, Fla.) 2010;22(48):5499-506.
2010: Andreas O Frank; Elke Otto; Carlos Mas-Moruno; Herbert B Schiller; Luciana Marinelli; Sandro Cosconati; Alexander Bochen; Dörte Vossmeyer; Grit Zahn; Roland Stragies; Ettore Novellino; Horst Kessler
Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch.
Angewandte Chemie (International ed. in English) 2010;49(48):9278-81.
2010: Ilka Varnay; Vincent Truffault; Sergej Djuranovic; Astrid Ursinus; Murray Coles; Horst Kessler
Optimized measurement temperature gives access to the solution structure of a 49 kDa homohexameric β-propeller.
Journal of the American Chemical Society 2010;132(44):15692-8.
2010: Daniel Aydin; Ilia Louban; Nadine Perschmann; Jacques Blümmel; Theobald Lohmüller; Elisabetta Ada Cavalcanti-Adam; Tobias L Haas; Henning Walczak; Horst Kessler; Roberto Fiammengo; Joachim P Spatz
Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation.
Langmuir : the ACS journal of surfaces and colloids 2010;26(19):15472-80.
2010: Sylvia Welker; Birgit Rudolph; Elke Frenzel; Franz Hagn; Gerhard Liebisch; Gerd Schmitz; Johannes Scheuring; Andreas Kerth; Alfred Blume; Sevil Weinkauf; Martin Haslbeck; Horst Kessler; Johannes Buchner
Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function.
Molecular cell 2010;39(4):507-20.
2010: Lucas Doedens; Florian Opperer; Minying Cai; Johannes G Beck; Matt Dedek; Erin Palmer; Victor J Hruby; Horst Kessler
Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies.
Journal of the American Chemical Society 2010;132(23):8115-28.
2010: Franz Hagn; Lukas Eisoldt; John G Hardy; Charlotte Vendrely; Murray Coles; Thomas Scheibel; Horst Kessler
A conserved spider silk domain acts as a molecular switch that controls fibre assembly.
Nature 2010;465(7295):239-42.
2010: Burkhardt Laufer; Andreas O Frank; Jayanta Chatterjee; Thomas Neubauer; Carles Mas-Moruno; Grit Kummerlöwe; Horst Kessler
The impact of amino acid side chain mutations in conformational design of peptides and proteins.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(18):5385-90.
2010: Alex G F de Beer; Elisabetta Ada Cavalcanti-Adam; Günter Majer; M Lopez-García; Horst Kessler; Joachim P Spatz
Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces.
Physical review. E, Statistical, nonlinear, and soft matter physics 2010;81(5 Pt 1):051914.
2010: C Selhuber-Unkel; T Erdmann; M López-García; Horst Kessler; Ulrich S Schwarz; Joachim P Spatz
Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors.
Biophysical journal 2010;98(4):543-51.
2010: Marco Retzlaff; Franz Hagn; Lars Mitschke; Martin Hessling; Frederik Gugel; Horst Kessler; Klaus Richter; Johannes Buchner
Asymmetric activation of the hsp90 dimer by its cochaperone aha1.
Molecular cell 2010;37(3):344-54.
2009: Oliver Schnell; Bjarne Krebs; Janette Carlsen; Isabelle Miederer; Claudia Goetz; Roland Goldbrunner; Hans-Jürgen Wester; Roland Haubner; Gabriele Pöpperl; Markus Holtmannspötter; Hans A Kretzschmar; Horst Kessler; Jörg-Christian Tonn; Markus Schwaiger; Ambros J Beer
Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography.
Neuro-oncology 2009;11(6):861-70.
2009: Marco Retzlaff; Michael Stahl; H Christian Eberl; Stephan Lagleder; Jürgen Beck; Horst Kessler; Johannes Buchner
Hsp90 is regulated by a switch point in the C-terminal domain.
EMBO reports 2009;10(10):1147-53.
2009: Timo Huber; Florian Manzenrieder; Christian Kuttruff; Cornelia Dorner-Ciossek; Horst Kessler
Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of beta-secretase (BACE1).
Bioorganic & medicinal chemistry letters 2009;19(15):4427-31.
2009: Margret Schottelius; Burkhardt Laufer; Horst Kessler; Hans-Jürgen Wester
Ligands for mapping alphavbeta3-integrin expression in vivo.
Accounts of chemical research 2009;42(7):969-80.
2009: Matthias J Feige; Sandra Groscurth; Moritz Marcinowski; Yuichiro Shimizu; Horst Kessler; Linda M Hendershot; Johannes Buchner
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.
Molecular cell 2009;34(5):569-79.
2009: Maya J Pandya; Henriette Bendz; Florian Manzenrieder; Elfriede Noessner; Horst Kessler; Johannes Buchner; Rolf Issels
Interaction of human heat shock protein 70 with tumor-associated peptides.
Biological chemistry 2009;390(4):305-12.
2009: Burkhardt Laufer; Jayanta Chatterjee; Andreas O Frank; Horst Kessler
Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?
Journal of peptide science : an official publication of the European Peptide Society 2009;15(3):141-6.
2009: Martin Hoefling; Horst Kessler; Kay-Eberhard Gottschalk
The transmembrane structure of integrin alphaIIbbeta3: significance for signal transduction.
Angewandte Chemie (International ed. in English) 2009;48(36):6590-3.
2009: Horst Kessler; Jayanta Chatterjee; Lucas Doedens; Florian Operrer; Eric Biron; Daniel Hoyer; Herbert Schmid; Chaim Gilon; Victor J Hruby; Dale F Mierkes
New perspective in peptide chemistry by N-alkylation.
Advances in experimental medicine and biology 2009;611():229-31.
2009: Jayanta Chatterjee; Oded Ovadia; Grit Zahn; Luciana Marinelli; Amnon Hoffman; Chaim Gilon; Horst Kessler
Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation.
Advances in experimental medicine and biology 2009;611():209-10.
2009: Burkhardt Laufer; Jayanta Chatterjee; Andreas O Frank; Horst Kessler
Making double-minded peptides strong-willed? The side chain impact on the backbone conformation of N-methylated cyclic pentapeptides.
Advances in experimental medicine and biology 2009;611():157-8.
2009: Sebastian Knör; Burkhardt Laufer; Alexey Khrenov; Abdellah Benhida; Sabrina C Grailly; Nathalie Beaufort; Viktor Magdolen; Charlotte A E Hauser; Evgueni L Saenko; Jean-Marie Saint-Remy; Horst Kessler
Development of a small molecule peptidomimetic affinity ligand for efficient purification of the large protein factor VIII.
Advances in experimental medicine and biology 2009;611():151-2.
2009: Jayanta Chatterjee; Oded Ovadia; Chaim Gilon; Amnon Hoffman; Dale Mierke; Horst Kessler
N-methylated cyclic pentapeptides as template structures.
Advances in experimental medicine and biology 2009;611():109-10.
2009: Florian Manzenrieder; Horst Kessler
Solid-phase synthesis of phosphinic dipepetide isosteres and beta amino acids via activated N-terminal acrylamides.
Advances in experimental medicine and biology 2009;611():11-2.
2009: Dominik Heckmann; Burkhardt Laufer; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Grit Zahn; Roland Stragies; Horst Kessler
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity.
Angewandte Chemie (International ed. in English) 2009;48(24):4436-40.
2008: Christine Selhuber-Unkel; Mónica López-García; Horst Kessler; Joachim P Spatz
Cooperativity in adhesion cluster formation during initial cell adhesion.
Biophysical journal 2008;95(11):5424-31.
2008: Grit Kummerlöwe; Sebastian Knör; Andreas O Frank; Thomas Paululat; Horst Kessler; Burkhard Luy
Deuterated polymer gels for measuring anisotropic NMR parameters with strongly reduced artefacts.
Chemical communications (Cambridge, England) 2008;(44):5722-4.
2008: Jochen Klages; Alexander Kotzsch; Murray Coles; Walter Sebald; Joachim Nickel; Thomas Müller; Horst Kessler
The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding.
Biochemistry 2008;47(46):11930-9.
2008: Jayanta Chatterjee; Chaim Gilon; Amnon Hoffman; Horst Kessler
N-methylation of peptides: a new perspective in medicinal chemistry.
Accounts of chemical research 2008;41(10):1331-42.
2008: Matthias J Feige; Sandra Groscurth; Moritz Marcinowski; Zu Thur Yew; Vincent Truffault; Emanuele Paci; Horst Kessler; Johannes Buchner
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13373-8.
2008: Vera C Hirschfeld-Warneken; Marco Arnold; Ada Cavalcanti-Adam; Mónica López-García; Horst Kessler; Joachim P Spatz
Cell adhesion and polarisation on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patches.
European journal of cell biology 2008;87(8-9):743-50.
2008: Marco Arnold; Vera C Hirschfeld-Warneken; Theobald Lohmüller; Patrick Heil; Jacques Blümmel; Elisabetta A Cavalcanti-Adam; Mónica López-García; Paul Walther; Horst Kessler; Benjamin Geiger; Joachim P Spatz
Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing.
Nano letters 2008;8(7):2063-9.
2008: Sviatlana Kalinina; Hartmut Gliemann; Mónica López-García; Andre Petershans; Jörg Auernheimer; Thomas Schimmel; Michael Bruns; Alexandra Schambony; Horst Kessler; Doris Wedlich
Isothiocyanate-functionalized RGD peptides for tailoring cell-adhesive surface patterns.
Biomaterials 2008;29(20):3004-13.
2008: Dominik Heckmann; Axel Meyer; Burkhardt Laufer; Grit Zahn; Roland Stragies; Horst Kessler
Rational design of highly active and selective ligands for the alpha5beta1 integrin receptor.
Chembiochem : a European journal of chemical biology 2008;9(9):1397-407.
2008: Doris Kaufmann; Anne Fiedler; Andreas Junger; Jörg Auernheimer; Horst Kessler; Ralf Weberskirch
Chemical conjugation of linear and cyclic RGD moieties to a recombinant elastin-mimetic polypeptide--a versatile approach towards bioactive protein hydrogels.
Macromolecular bioscience 2008;8(6):577-88.
2008: Andreas Enthart; J Christoph Freudenberger; Julien Furrer; Horst Kessler; Burkhard Luy
The CLIP/CLAP-HSQC: pure absorptive spectra for the measurement of one-bond couplings.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2008;192(2):314-22.
2008: O Demmer; I Dijkgraaf; Margret Schottelius; Hans-Jürgen Wester; Horst Kessler
Introduction of functional groups into peptides via N-alkylation.
Organic letters 2008;10(10):2015-8.
2008: Sebastian Knör; Alexey V Khrenov; B Laufer; Abdellah Benhida; Sabrina Grailly; R Schwaab; J Oldenburg; Nathalie Beaufort; Viktor Magdolen; Jean-Marie Saint-Remy; Evgueni L Saenko; Charlotte A E Hauser; Horst Kessler
Efficient factor VIII affinity purification using a small synthetic ligand.
Journal of thrombosis and haemostasis : JTH 2008;6(3):470-7.
2008: Florian Manzenrieder; Andreas O Frank; Horst Kessler
Phosphorus NMR spectroscopy as a versatile tool for compound library screening.
Angewandte Chemie (International ed. in English) 2008;47(14):2608-11.
2008: Eric Biron; Jayanta Chatterjee; Oded Ovadia; Daniel Langenegger; Joseph Brueggen; Daniel Hoyer; Herbert A Schmid; Raz Jelinek; Chaim Gilon; Amnon Hoffman; Horst Kessler
Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.
Angewandte Chemie (International ed. in English) 2008;47(14):2595-9.
2008: Jayanta Chatterjee; Dale F Mierke; Horst Kessler
Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(5):1508-17.
2008: Sebastian Knör; Sumito Sato; Timo Huber; Alfred Morgenstern; Frank Bruchertseifer; Manfred Schmitt; Horst Kessler; Reingard Senekowitsch-Schmidtke; Viktor Magdolen; Christof Seidl
Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer.
European journal of nuclear medicine and molecular imaging 2008;35(1):53-64.
2007: Jochen Klages; Horst Kessler; Steffen J Glaser; Burkhard Luy
J-ONLY-TOCSY: efficient suppression of RDC-induced transfer in homonuclear TOCSY experiments using JESTER-1-derived multiple pulse sequences.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2007;189(2):217-27.
2007: Jayanta Chatterjee; Oded Ovadia; Grit Zahn; Luciana Marinelli; Amnon Hoffman; Chaim Gilon; Horst Kessler
Multiple N-methylation by a designed approach enhances receptor selectivity.
Journal of medicinal chemistry 2007;50(24):5878-81.
2007: Jacques Blümmel; Nadine Perschmann; Daniel Aydin; Jovana Drinjakovic; Thomas Surrey; Monica Lopez-Garcia; Horst Kessler; Joachim P Spatz
Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces.
Biomaterials 2007;28(32):4739-47.
2007: Sebastian Knör; Alexey V Khrenov; Burkhardt Laufer; Evgueni L Saenko; Charlotte A E Hauser; Horst Kessler
Development of a peptidomimetic ligand for efficient isolation and purification of factor VIII via affinity chromatography.
Journal of medicinal chemistry 2007;50(18):4329-39.
2007: Oliver Lieleg; Mónica López-García; Christine Semmrich; Jörg Auernheimer; Horst Kessler; Andreas R Bausch
Specific integrin labeling in living cells using functionalized nanocrystals.
Small (Weinheim an der Bergstrasse, Germany) 2007;3(9):1560-5.
2007: Jochen Klages; Murray Coles; Horst Kessler
NMR-based screening: a powerful tool in fragment-based drug discovery.
The Analyst 2007;132(7):693-705.
2007: Florian Manzenrieder; Andreas O Frank; Timo Huber; Cornelia Dorner-Ciossek; Horst Kessler
Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human beta-secretase (BACE1).
Bioorganic & medicinal chemistry 2007;15(12):4136-43.
2007: Stefan V Graeter; Jinghuan Huang; Nadine Perschmann; Mónica López-García; Horst Kessler; Jiandong Ding; Joachim P Spatz
Mimicking cellular environments by nanostructured soft interfaces.
Nano letters 2007;7(5):1413-8.
2007: Elisabetta Ada Cavalcanti-Adam; Tova Volberg; Alexandre Micoulet; Horst Kessler; Benjamin Geiger; Joachim P Spatz
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands.
Biophysical journal 2007;92(8):2964-74.
2007: Julien Furrer; Michael John; Horst Kessler; Burkhard Luy
J-Spectroscopy in the presence of residual dipolar couplings: determination of one-bond coupling constants and scalable resolution.
Journal of biomolecular NMR 2007;37(3):231-43.
2007: Matthias J Feige; Franz Hagn; Julia Esser; Horst Kessler; Johannes Buchner
Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain.
Journal of molecular biology 2007;365(4):1232-44.
2007: Sebastian Knör; Armin Modlinger; Thorsten Poethko; Margret Schottelius; Hans-Jürgen Wester; Horst Kessler
Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(21):6082-90.
2007: Dominik Heckmann; Axel Meyer; Luciana Marinelli; Grit Zahn; Roland Stragies; Horst Kessler
Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor.
Angewandte Chemie (International ed. in English) 2007;46(19):3571-4.
2006: Jayanta Chatterjee; Dale F Mierke; Horst Kessler
N-methylated cyclic pentaalanine peptides as template structures.
Journal of the American Chemical Society 2006;128(47):15164-72.
2006: Markus Heller; Martin Sukopp; Natia Tsomaia; Michael John; Dale F Mierke; Bernd Reif; Horst Kessler
The conformation of cyclo(-D-Pro-Ala4-) as a model for cyclic pentapeptides of the DL4 type.
Journal of the American Chemical Society 2006;128(42):13806-14.
2006: Lin Römer; Christian Klein; Alexander Dehner; Horst Kessler; Johannes Buchner
p53--a natural cancer killer: structural insights and therapeutic concepts.
Angewandte Chemie (International ed. in English) 2006;45(39):6440-60.
2006: Sebastian Knör; Burkhardt Laufer; Horst Kessler
Efficient enantioselective synthesis of condensed and aromatic-ring-substituted tyrosine derivatives.
The Journal of organic chemistry 2006;71(15):5625-30.
2006: Mandar Deshmukh; Michael John; Murray Coles; Jürgen Peters; Wolfgang Baumeister; Horst Kessler
Inter-domain orientation and motions in VAT-N explored by residual dipolar couplings and 15N backbone relaxation.
Magnetic resonance in chemistry : MRC 2006;44 Spec No():S89-S100.
2006: Daniela Lössner; Horst Kessler; Georgette Thumshirn; Claudia Dahmen; Birgit Wiltschi; Motomu Tanaka; Wolfgang Knoll; Eva-Kathrin Sinner; Ute Reuning
Binding of small mono- and oligomeric integrin ligands to membrane-embedded integrins monitored by surface plasmon-enhanced fluorescence spectroscopy.
Analytical chemistry 2006;78(13):4524-33.
2006: Ulla Magdolen; Jörg Auernheimer; Claudia Dahmen; Johannes Schauwecker; Hans Gollwitzer; Jutta Tübel; Reiner Gradinger; Horst Kessler; Manfred Schmitt; Peter Diehl
Growth promoting in vitro effect of synthetic cyclic RGD-peptides on human osteoblast-like cells attached to cancellous bone.
International journal of molecular medicine 2006;17(6):1017-21.
2006: Eric Biron; Jayanta Chatterjee; Horst Kessler
Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics.
Organic letters 2006;8(11):2417-20.
2006: Michael John; Michaela Wendeler; Markus Heller; Konrad Sandhoff; Horst Kessler
Characterization of human saposins by NMR spectroscopy.
Biochemistry 2006;45(16):5206-16.
2006: Klaus Richter; Sandra Moser; Franz Hagn; Rainer Friedrich; Otmar Hainzl; Markus Heller; Sandra Schlee; Horst Kessler; Jochen Reinstein; Johannes Buchner
Intrinsic inhibition of the Hsp90 ATPase activity.
The Journal of biological chemistry 2006;281(16):11301-11.
2006: Melina Haupt; Marc Bramkamp; Markus Heller; Murray Coles; Gabriele Deckers-Hebestreit; Brigitte Herkenhoff-Hesselmann; Karlheinz Altendorf; Horst Kessler
The holo-form of the nucleotide binding domain of the KdpFABC complex from Escherichia coli reveals a new binding mode.
The Journal of biological chemistry 2006;281(14):9641-9.
2006: Elisabetta Ada Cavalcanti-Adam; Alexandre Micoulet; Jacques Blümmel; Jörg Auernheimer; Horst Kessler; Joachim P Spatz
Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly.
European journal of cell biology 2006;85(3-4):219-24.
2006: Nadine Walter; Christine Selhuber; Horst Kessler; Joachim P Spatz
Cellular unbinding forces of initial adhesion processes on nanopatterned surfaces probed with magnetic tweezers.
Nano letters 2006;6(3):398-402.
2006: Eric Biron; Jayanta Chatterjee; Horst Kessler
Optimized selective N-methylation of peptides on solid support.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(3):213-9.
2006: Jörg Auernheimer; Horst Kessler
Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium.
Bioorganic & medicinal chemistry letters 2006;16(2):271-3.
2006: A Meyer; Jörg Auernheimer; A Modlinger; Horst Kessler
Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting.
Current pharmaceutical design 2006;12(22):2723-47.
2006: Timo Weide; Lars Arve; Heino Prinz; Herbert Waldmann; Horst Kessler
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(1):59-63.
2005: Jörg Auernheimer; Claudia Dahmen; Ulrich Hersel; Andreas R Bausch; Horst Kessler
Photoswitched cell adhesion on surfaces with RGD peptides.
Journal of the American Chemical Society 2005;127(46):16107-10.
2005: Jörg Auernheimer; Daniel Zukowski; Claudia Dahmen; Martin Kantlehner; Anja Enderle; Simon L Goodman; Horst Kessler
Titanium implant materials with improved biocompatibility through coating with phosphonate-anchored cyclic RGD peptides.
Chembiochem : a European journal of chemical biology 2005;6(11):2034-40.
2005: Jochen Klages; Cajetan Neubauer; Murray Coles; Horst Kessler; Burkhard Luy
Structure refinement of cyclosporin A in chloroform by using RDCs measured in a stretched PDMS-gel.
Chembiochem : a European journal of chemical biology 2005;6(9):1672-8.
2005: Alexander Dehner; Horst Kessler
Diffusion NMR spectroscopy: folding and aggregation of domains in p53.
Chembiochem : a European journal of chemical biology 2005;6(9):1550-65.
2005: Alexander Dehner; Christian Klein; Silke Hansen; Lin Müller; Johannes Buchner; Manfred Schwaiger; Horst Kessler
Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge.
Angewandte Chemie (International ed. in English) 2005;44(33):5247-51.
2005: Luciana Marinelli; Axel Meyer; Dominik Heckmann; Antonio Lavecchia; Ettore Novellino; Horst Kessler
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Journal of medicinal chemistry 2005;48(13):4204-7.
2005: Eric Biron; Horst Kessler
Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis.
The Journal of organic chemistry 2005;70(13):5183-9.
2005: Kyryl Kobzar; Horst Kessler; Burkhard Luy
Stretched gelatin gels as chiral alignment media for the discrimination of enantiomers by NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2005;44(20):3145-7.
2005: Burkhard Luy; Kyryl Kobzar; Sebastian Knör; Julien Furrer; Dominik Heckmann; Horst Kessler
Orientational properties of stretched polystyrene gels in organic solvents and the suppression of their residual 1H NMR signals.
Journal of the American Chemical Society 2005;127(17):6459-65.
2005: Esther Lieb; Michael Hacker; Jörg Tessmar; L A Kunz-Schughart; J Fiedler; Claudia Dahmen; Ulrich Hersel; Horst Kessler; Michaela B Schulz; Achim Göpferich
Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides.
Biomaterials 2005;26(15):2333-41.
2005: Martin Sukopp; Richard Schwab; Luciana Marinelli; Eric Biron; Markus Heller; Edit Várkondi; Akos Pap; Ettore Novellino; György Kéri; Horst Kessler
Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid.
Journal of medicinal chemistry 2005;48(8):2916-26.
2005: Mandar Deshmukh; Georg Voll; Angelika Kühlewein; Helmut R Mäcke; Jörg Schmitt; Horst Kessler; Gerd Gemmecker
NMR studies reveal structural differences between the gallium and yttrium complexes of DOTA-D-Phe1-Tyr3-octreotide.
Journal of medicinal chemistry 2005;48(5):1506-14.
2005: Veronika Beck; Hannes Herold; Anke Benge; Birgit Luber; Peter Hutzler; Harald Tschesche; Horst Kessler; Manfred Schmitt; Harald-Gerhard Geppert; Ute Reuning
ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion.
The international journal of biochemistry & cell biology 2005;37(3):590-603.
2005: J Christoph Freudenberger; Sebastian Knör; Kyryl Kobzar; Dominik Heckmann; Thomas Paululat; Horst Kessler; Burkhard Luy
Stretched poly(vinyl acetate) gels as NMR alignment media for the measurement of residual dipolar couplings in polar organic solvents.
Angewandte Chemie (International ed. in English) 2005;44(3):423-6.
2005: Melina Haupt; Marc Bramkamp; Murray Coles; Horst Kessler; Karlheinz Altendorf
Prokaryotic Kdp-ATPase: recent insights into the structure and function of KdpB.
Journal of molecular microbiology and biotechnology 2005;10(2-4):120-31.
2004: Claudia Dahmen; Jörg Auernheimer; Axel Meyer; Anja Enderle; Simon L Goodman; Horst Kessler
Improving implant materials by coating with nonpeptidic, highly specific integrin ligands.
Angewandte Chemie (International ed. in English) 2004;43(48):6649-52.
2004: Melina Haupt; Marc Bramkamp; Murray Coles; Karlheinz Altendorf; Horst Kessler
Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes.
Journal of molecular biology 2004;342(5):1547-58.
2004: Angelika Kühlewein; Georg Voll; Birte Hernandez Alvarez; Horst Kessler; Gunter Fischer; Jens-Ulrich Rahfeld; Gerd Gemmecker
Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases.
Protein science : a publication of the Protein Society 2004;13(9):2378-87.
2004: Luciana Marinelli; Kay-Eberhard Gottschalk; Axel Meyer; Ettore Novellino; Horst Kessler
Human integrin alphavbeta5: homology modeling and ligand binding.
Journal of medicinal chemistry 2004;47(17):4166-77.
2004: Melina Haupt; Murray Coles; Vincent Truffault; Marc Bramkamp; Karlheinz Altendorf; Horst Kessler
1H, 13C and 15N resonance assignment of the nucleotide binding domain of KdpB from Escherichia coli.
Journal of biomolecular NMR 2004;29(3):437-8.
2004: Kay-Eberhard Gottschalk; Horst Kessler
A computational model of transmembrane integrin clustering.
Structure (London, England : 1993) 2004;12(6):1109-16.
2004: Kay-Eberhard Gottschalk; Misha Soskine; Shimon Schuldiner; Horst Kessler
A structural model of EmrE, a multi-drug transporter from Escherichia coli.
Biophysical journal 2004;86(6):3335-48.
2004: Margret Schottelius; Thorsten Poethko; Michael Herz; Jean Claude Reubi; Horst Kessler; Markus Schwaiger; Hans-Jürgen Wester
First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3593-606.
2004: Thorsten Poethko; Margret Schottelius; Georgette Thumshirn; Ulrich Hersel; Michael Herz; Gjermund Henriksen; Horst Kessler; Markus Schwaiger; Hans-Jürgen Wester
Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(5):892-902.
2004: Marco Arnold; Elisabetta Ada Cavalcanti-Adam; Roman Glass; Jacques Blümmel; Wolfgang Eck; Martin Kantlehner; Horst Kessler; Joachim P Spatz
Activation of integrin function by nanopatterned adhesive interfaces.
Chemphyschem : a European journal of chemical physics and physical chemistry 2004;5(3):383-8.
2004: C Riemer; T Bayer; H Schmitt; Horst Kessler
3-Azido-aspartic acid derivatives - orthogonally protected precursors for the stereoselective incorporation of 2,3-diaminosuccinic acid into peptide structures.
The journal of peptide research : official journal of the American Peptide Society 2004;63(3):196-9.
2004: Michaela Wendeler; Joerg Hoernschemeyer; Michael John; Norbert Werth; Maike Schoeniger; Thorsten Lemm; Rudolf Hartmann; Horst Kessler; Konrad Sandhoff
Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization.
Protein expression and purification 2004;34(1):147-57.
2004: Markus Heller; Michael John; Murray Coles; Gundula Bosch; Wolfgang Baumeister; Horst Kessler
NMR studies on the substrate-binding domains of the thermosome: structural plasticity in the protrusion region.
Journal of molecular biology 2004;336(3):717-29.
2004: Burkhard Luy; Kyryl Kobzar; Horst Kessler
An easy and scalable method for the partial alignment of organic molecules for measuring residual dipolar couplings.
Angewandte Chemie (International ed. in English) 2004;43(9):1092-4.
2004: Kay-Eberhard Gottschalk; Horst Kessler
Evidence for hetero-association of transmembrane helices of integrins.
FEBS letters 2004;557(1-3):253-8.
2003: Elsa Locardi; Jürgen Boer; Armin Modlinger; Anja Schuster; Bernhard Holzmann; Horst Kessler
Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1.
Journal of medicinal chemistry 2003;46(26):5752-62.
2003: Enrique Mann; Horst Kessler
New oxazole-based peptidomimetics: useful building blocks for the synthesis of orthogonally protected macrocyclic scaffolds.
Organic letters 2003;5(24):4567-70.
2003: Ulrich Hersel; Claudia Dahmen; Horst Kessler
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond.
Biomaterials 2003;24(24):4385-415.
2003: Luciana Marinelli; Antonio Lavecchia; Kay-Eberhard Gottschalk; Ettore Novellino; Horst Kessler
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design.
Journal of medicinal chemistry 2003;46(21):4393-404.
2003: Roger Dawson; Lin Müller; Alexander Dehner; Christian Klein; Horst Kessler; Johannes Buchner
The N-terminal domain of p53 is natively unfolded.
Journal of molecular biology 2003;332(5):1131-41.
2003: Renate M van Well; Luciana Marinelli; Cornelis Altona; Kees Erkelens; Gregg Siegal; Mark van Raaij; Antonio Luis Llamas-Saiz; Horst Kessler; Ettore Novellino; Antonio Lavecchia; Jacques H van Boom; Mark Overhand
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure.
Journal of the American Chemical Society 2003;125(36):10822-9.
2003: Alexander Dehner; Julien Furrer; Klaus Richter; Ioana Schuster; Johannes Buchner; Horst Kessler
NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol.
Chembiochem : a European journal of chemical biology 2003;4(9):870-7.
2003: Murray Coles; Markus Heller; Horst Kessler
NMR-based screening technologies.
Drug discovery today 2003;8(17):803-10.
2003: Julien Furrer; Andreas Enthart; Angelika Kühlewein; Alexander Dehner; Christian Klein; Silke Hansen; Manfred Schwaiger; Horst Kessler; Gerd Gemmecker
Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein.
Journal of biomolecular NMR 2003;26(4):377-8.
2003: Sandra Hapke; Horst Kessler; Birgit Luber; Anke Benge; Peter Hutzler; Heinz Höfler; Manfred Schmitt; Ute Reuning
Ovarian cancer cell proliferation and motility is induced by engagement of integrin alpha(v)beta3/Vitronectin interaction.
Biological chemistry 2003;384(7):1073-83.
2003: Georgette Thumshirn; Ulrich Hersel; Simon L Goodman; Horst Kessler
Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(12):2717-25.
2003: Dirk Weber; Claudia Berger; Peter Eickelmann; Jochen Antel; Horst Kessler
Design of selective peptidomimetic agonists for the human orphan receptor BRS-3.
Journal of medicinal chemistry 2003;46(10):1918-30.
2003: René Mühlberger; Rudolf Robelek; Wolfgang Eisenreich; Christian Ettenhuber; Eva-Kathrin Sinner; Horst Kessler; Adelbert Bacher; Gerald Richter
RNA DNA discrimination by the antitermination protein NusB.
Journal of molecular biology 2003;327(5):973-83.
2003: Ute Reuning; Stefan Sperl; Charlotte Kopitz; Horst Kessler; Achim Krüger; Manfred Schmitt; Viktor Magdolen
Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo.
Current pharmaceutical design 2003;9(19):1529-43.
2003: Elke Guthaus; Niko Schmiedeberg; Markus Bürgle; Viktor Magdolen; Horst Kessler; Manfred Schmitt
The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;162():3-14.
2002: Niko Schmiedeberg; Manfred Schmitt; Christian Rölz; Vincent Truffault; Martin Sukopp; Markus Bürgle; Olaf G Wilhelm; Wolfgang Schmalix; Viktor Magdolen; Horst Kessler
Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics.
Journal of medicinal chemistry 2002;45(23):4984-94.
2002: Kay-Eberhard Gottschalk; Horst Kessler
The structures of integrins and integrin-ligand complexes: implications for drug design and signal transduction.
Angewandte Chemie (International ed. in English) 2002;41(20):3767-74.
2002: Sibylle A W Gruner; Vincent Truffault; Georg Voll; Elsa Locardi; Matthias Stöckle; Horst Kessler
Design, synthesis, and NMR structure of linear and cyclic oligomers containing novel furanoid sugar amino acids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(19):4365-76.
2002: Sumito Sato; Charlotte Kopitz; Wolfgang A Schmalix; Bernd Muehlenweg; Horst Kessler; Manfred Schmitt; Achim Krüger; Viktor Magdolen
High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread.
FEBS letters 2002;528(1-3):212-6.
2002: Dirk Gottschling; Jürgen Boer; Anja Schuster; Bernhard Holzmann; Horst Kessler
Combinatorial and rational strategies to develop nonpeptidic alpha4beta7-integrin antagonists from cyclic peptides.
Angewandte Chemie (International ed. in English) 2002;41(16):3007-11.
2002: Dirk Weber; Claudia Berger; Timo Heinrich; Peter Eickelmann; Jochen Antel; Horst Kessler
Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3.
Journal of peptide science : an official publication of the European Peptide Society 2002;8(8):461-75.
2002: Brigitte Jeschke; Jörg Meyer; Alfred Jonczyk; Horst Kessler; Peter Adamietz; Norbert M Meenen; Martin Kantlehner; Christiane Goepfert; Berthold Nies
RGD-peptides for tissue engineering of articular cartilage.
Biomaterials 2002;23(16):3455-63.
2002: Matthias Stöckle; Georg Voll; Robert Günther; Elisabeth Lohof; Elsa Locardi; Sibylle A W Gruner; Horst Kessler
Synthesis and NMR studies of cyclopeptides containing a sugar amino Acid.
Organic letters 2002;4(15):2501-4.
2002: Kay-Eberhard Gottschalk; Paul D Adams; Axel T Brunger; Horst Kessler
Transmembrane signal transduction of the alpha(IIb)beta(3) integrin.
Protein science : a publication of the Protein Society 2002;11(7):1800-12.
2002: Dirk Gottschling; Jürgen Boer; Luciana Marinelli; Georg Voll; Melina Haupt; Anja Schuster; Bernhard Holzmann; Horst Kessler
Synthesis and NMR structure of peptidomimetic alpha4beta7-integrin antagonists.
Chembiochem : a European journal of chemical biology 2002;3(6):575-8.
2002: Kay-Eberhard Gottschalk; Robert Günther; Horst Kessler
A three-state mechanism of integrin activation and signal transduction for integrin alpha(v)beta(3).
Chembiochem : a European journal of chemical biology 2002;3(5):470-3.
2002: Holger Lüttgen; Rudolf Robelek; René Mühlberger; Tammo Diercks; Stephan C Schuster; Peter Köhler; Horst Kessler; Adelbert Bacher; Gerald Richter
Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli.
Journal of molecular biology 2002;316(4):875-85.
2002: Simon L Goodman; Günter Hölzemann; Gábor A G Sulyok; Horst Kessler
Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.
Journal of medicinal chemistry 2002;45(5):1045-51.
2002: Sibylle A W Gruner; Elsa Locardi; Elisabeth Lohof; Horst Kessler
Carbohydrate-based mimetics in drug design: sugar amino acids and carbohydrate scaffolds.
Chemical reviews 2002;102(2):491-514.
2002: Elke Guthaus; Markus Bürgle; Niko Schmiedeberg; Stefan Hocke; Alexandra Eickler; Michael D Kramer; C G J Sweep; Viktor Magdolen; Horst Kessler; Manfred Schmitt
uPA-silica-Particles (SP-uPA): a novel analytical system to investigate uPA-uPAR interaction and to test synthetic uPAR antagonists as potential cancer therapeutics.
Biological chemistry 2002;383(1):207-16.
2001: Christian Klein; E Planker; Tammo Diercks; Horst Kessler; Klaus-Peter Künkele; K Lang; S Hansen; M Schwaiger
NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA.
The Journal of biological chemistry 2001;276(52):49020-7.
2001: Dirk Gottschling; Jürgen Boer; Anja Schuster; Bernhard Holzmann; Horst Kessler
Cellular solid-phase binding assay and mass spectrometry for screening of alpha 4 beta 7 integrin antagonists.
Bioorganic & medicinal chemistry letters 2001;11(23):2997-3000.
2001: Elsa Locardi; Matthias Stöckle; Sibylle A W Gruner; Horst Kessler
Cyclic homooligomers from sugar amino acids: synthesis, conformational analysis, and significance.
Journal of the American Chemical Society 2001;123(34):8189-96.
2001: Jürgen Boer; Dirk Gottschling; Anja Schuster; Monika Semmrich; Bernhard Holzmann; Horst Kessler
Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists.
Journal of medicinal chemistry 2001;44(16):2586-92.
2001: Viktor Magdolen; Markus Bürgle; N A de Prada; Niko Schmiedeberg; C Riemer; Florian Schroeck; Josef Kellermann; Klaus Degitz; Olaf G Wilhelm; Manfred Schmitt; Horst Kessler
Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87).
Biological chemistry 2001;382(8):1197-205.
2001: Sandra Hapke; Horst Kessler; Nuria Arroyo De Prada; Anke Benge; Manfred Schmitt; Ernst Lengyel; Ute Reuning
Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
The Journal of biological chemistry 2001;276(28):26340-8.
2001: Alexander Dehner; E Planker; Gerd Gemmecker; Quirinus B Broxterman; W Bisson; Fernando Formaggio; Marco Crisma; C Toniolo; Horst Kessler
Solution structure, dimerization, and dynamics of a lipophilic alpha/3(10)-helical, C alpha-methylated peptide. Implications for folding of membrane proteins.
Journal of the American Chemical Society 2001;123(27):6678-86.
2001: Vincent Truffault; Murray Coles; Tammo Diercks; K Abelmann; Sabine Eberhardt; Holger Lüttgen; Adelbert Bacher; Horst Kessler
The solution structure of the N-terminal domain of riboflavin synthase.
Journal of molecular biology 2001;309(4):949-60.
2001: G A Sulyok; C Gibson; Simon L Goodman; Günter Hölzemann; Matthias Wiesner; Horst Kessler
Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective alphavbeta3 integrin antagonists.
Journal of medicinal chemistry 2001;44(12):1938-50.
2001: Tammo Diercks; M Coles; Horst Kessler
Applications of NMR in drug discovery.
Current opinion in chemical biology 2001;5(3):285-91.
2001: T Bayer; C Riemer; Horst Kessler
A new strategy for the synthesis of cyclopeptides containing diaminoglutaric acid.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(5):250-61.
2000: Clemens Glaubitz; A Gröger; Kay-Eberhard Gottschalk; Paul J R Spooner; Anthony Watts; Shimon Schuldiner; Horst Kessler
31P-CP-MAS NMR studies on TPP+ bound to the ion-coupled multidrug transport protein EmrE.
FEBS letters 2000;480(2-3):127-31.
2000: Martin Kantlehner; P Schaffner; D Finsinger; Jörg Meyer; Alfred Jonczyk; B Diefenbach; Berthold Nies; Günter Hölzemann; Simon L Goodman; Horst Kessler
Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation.
Chembiochem : a European journal of chemical biology 2000;1(2):107-14.
2000: Bernd Muehlenweg; Elke Guthaus; N A de Prada; Manfred Schmitt; Niko Schmiedeberg; Matthias Kotzsch; Sabine Creutzburg; Michael D Kramer; Horst Kessler; Olaf G Wilhelm; Viktor Magdolen
Epitope mapping of monoclonal antibodies directed to PAI-1 using PAI-1/PAI-2 chimera and PAI-1-derived synthetic peptides.
Thrombosis research 2000;98(1):73-81.
1999: P Schaffner; Jörg Meyer; Michel Dard; R Wenz; Berthold Nies; S Verrier; Horst Kessler; Martin Kantlehner
Induced tissue integration of bone implants by coating with bone selective RGD-peptides in vitro and in vivo studies.
Journal of materials science. Materials in medicine 1999;10(12):837-9.
1999: Murray Coles; Tammo Diercks; J Liermann; A Gröger; B Rockel; Wolfgang Baumeister; Kristin K Koretke; Andrei N Lupas; J Peters; Horst Kessler
The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple betaalphabetabeta element.
Current biology : CB 1999;9(20):1158-68.
1999: Tammo Diercks; Murray Coles; Horst Kessler
An efficient strategy for assignment of cross-peaks in 3D heteronuclear NOESY experiments.
Journal of biomolecular NMR 1999;15(2):177-80.
1999: M A Dechantsreiter; E Planker; B Mathä; Elisabeth Lohof; Günter Hölzemann; Alfred Jonczyk; Simon L Goodman; Horst Kessler
N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
Journal of medicinal chemistry 1999;42(16):3033-40.
1999: Murray Coles; Tammo Diercks; Bernd Muehlenweg; S Bartsch; V Zölzer; Harald Tschesche; Horst Kessler
The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.
Journal of molecular biology 1999;289(1):139-57.
1999: RM Gschwind; Horst Kessler; Gerd Gemmecker
A new multi-quantum version of the HBHA(CBCACO)NH experiment with enhanced sensitivity for partially deuterated samples.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1999;137(1):285-8.
1998: K Fischer; Verena Lutz; Olaf G Wilhelm; Manfred Schmitt; Henner Graeff; P Heiss; T Nishiguchi; Nadia Harbeck; Horst Kessler; Thomas Luther; Viktor Magdolen; Ute Reuning
Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function.
FEBS letters 1998;438(1-2):101-5.
1998: M Schwaiger; Mario Lebendiker; H Yerushalmi; Murray Coles; A Gröger; C Schwarz; Shimon Schuldiner; Horst Kessler
NMR investigation of the multidrug transporter EmrE, an integral membrane protein.
European journal of biochemistry / FEBS 1998;254(3):610-9.
1998: Martin Bachelin; G Hessler; G Kurz; J G Hacia; P B Dervan; Horst Kessler
Structure of a stereoregular phosphorothioate DNA/RNA duplex.
Nature structural biology 1998;5(4):271-6.
1998: J Schmitt; Michael Bernd; Bernhard Kutscher; Horst Kessler
Synthesis of Dolastatin 15 mimetic peptoids.
Bioorganic & medicinal chemistry letters 1998;8(4):385-8.
1998: RM Gschwind; Gerd Gemmecker; Horst Kessler
A Spin System Labeled and Highly Resolved ed-H(CCO)NH-TOCSY Experiment for the Facilitated Assignment of Proton Side Chains in Partially Deuterated Samples.
Journal of biomolecular NMR 1998;11(2):191-8.
1998: Viktor Magdolen; Sybille Albrecht; Matthias Kotzsch; C Haller; Markus Bürgle; Uwe Jacob; Marianne Grosser; Horst Kessler; Henner Graeff; M Müller; Manfred Schmitt; Thomas Luther
Immunological and functional analyses of the extracellular domain of human tissue factor.
Biological chemistry 1998;379(2):157-65.
1998: Tammo Diercks; M Schwaiger; Horst Kessler
HSQC-based methyl group selection via gradients in mutidimensional NMR spectroscopy of proteins.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1998;130(2):335-40.
1998: M Leutner; RM Gschwind; J Liermann; C Schwarz; Gerd Gemmecker; Horst Kessler
Automated backbone assignment of labeled proteins using the threshold accepting algorithm.
Journal of biomolecular NMR 1998;11(1):31-43.
1997: F Berglechner; Gerald Richter; Markus Fischer; Adelbert Bacher; RM Gschwind; M Huenges; Gerd Gemmecker; Horst Kessler
Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy.
European journal of biochemistry / FEBS 1997;248(2):338-46.
1997: Gerd Gemmecker; M Eberstadt; A Buhr; Roland Lanz; S G Grdadolnik; Horst Kessler; Bernhard Erni
Glucose transporter of Escherichia coli: NMR characterization of the phosphocysteine form of the IIB(Glc) domain and its binding interface with the IIA(Glc) subunit.
Biochemistry 1997;36(24):7408-17.
1997: Thomas Luther; Viktor Magdolen; Sybille Albrecht; M Kasper; C Riemer; Horst Kessler; Henner Graeff; M Müller; Manfred Schmitt
Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue.
The American journal of pathology 1997;150(4):1231-44.
1997: RM Gschwind; Gerd Gemmecker; M Leutner; Horst Kessler; Regula Gutknecht; Roland Lanz; Karin Flükiger; Bernhard Erni
Secondary structure of the IIB domain of the Escherichia coli mannose transporter, a new fold in the class of alpha/beta twisted open-sheet structures.
FEBS letters 1997;404(1):45-50.
1997: Markus Bürgle; M Koppitz; C Riemer; Horst Kessler; B König; U H Weidle; Josef Kellermann; F Lottspeich; Henner Graeff; Manfred Schmitt; L Goretzki; Ute Reuning; Olaf G Wilhelm; Viktor Magdolen
Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides.
Biological chemistry 1997;378(3-4):231-7.
1996: M Eberstadt; Simona Golic Grdadolnik; Gerd Gemmecker; Horst Kessler; Andreas Buhr; Bernhard Erni
Solution structure of the IIB domain of the glucose transporter of Escherichia coli.
Biochemistry 1996;35(35):11286-92.
1994: W Jahnke; Horst Kessler
Enhanced sensitivity of rapidly exchanging amide protons by improved phase cycling and the constructive use of radiation damping.
Journal of biomolecular NMR 1994;4(5):735-40.
1994: W Jahnke; D F Mierke; L Béress; Horst Kessler
Structure of cobra cardiotoxin CTX I as derived from nuclear magnetic resonance spectroscopy and distance geometry calculations.
Journal of molecular biology 1994;240(5):445-58.
1994: Simona Golic Grdadolnik; D F Mierke; G Byk; Irina Zeltser; Chaim Gilon; Horst Kessler
Comparison of the conformation of active and nonactive backbone cyclic analogs of substance P as a tool to elucidate features of the bioactive conformation: NMR and molecular dynamics in DMSO and water.
Journal of medicinal chemistry 1994;37(14):2145-52.
1994: S Seip; J Balbach; S Behrens; Horst Kessler; Karin Flükiger; R de Meyer; Bernhard Erni
Mannose transporter of Escherichia coli. Backbone assignments and secondary structure of the IIA domain of the IIABMan subunit.
Biochemistry 1994;33(23):7174-83.
1994: S Golic Grdadolnik; M Eberstadt; Gerd Gemmecker; Horst Kessler; Andreas Buhr; Bernhard Erni
The glucose transporter of Escherichia coli. Assignment of the 1H, 13C and 15N resonances and identification of the secondary structure of the soluble IIB domain.
European journal of biochemistry / FEBS 1994;219(3):945-52.