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Levon Khachigian

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Anjali V Sheahan; Phoebe A Phillips; Levon M Khachigian
Therapeutic perspectives on pancreatic cancer.
Grace P C Yee; Paul de Souza; Levon M Khachigian
Current and potential treatments for cervical cancer.
E Sanchez-Guerrero; B H Chong; S R Jo; Levon M Khachigian
EGFR and the complexity of receptor crosstalk in the cardiovascular system.

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2013: Anjali V Sheahan; Phoebe A Phillips; Levon M Khachigian
Therapeutic perspectives on pancreatic cancer.
Current cancer drug targets 2013;13(4):400-10.
2013: Grace P C Yee; Paul de Souza; Levon M Khachigian
Current and potential treatments for cervical cancer.
Current cancer drug targets 2013;13(2):205-20.
2013: E Sanchez-Guerrero; B H Chong; S R Jo; Levon M Khachigian
EGFR and the complexity of receptor crosstalk in the cardiovascular system.
Current molecular medicine 2013;13(1):3-12.
2012: Peter J Little; Mandy L Ballinger; Robel Getachew; Levon M Khachigian; Sufen Liao; Hossein Babaahmadi Rezaei; Estella Sanchez-Guerrero; Haitao Wang; Wenhua Zheng; Narin Osman
Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation.
Archives of biochemistry and biophysics 2012;525(1):25-31.
2012: Nor Saadah M Azahri; Belinda A Di Bartolo; Levon M Khachigian; Mary M Kavurma
Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: mechanisms of PDGF-BB-mediated VSMC proliferation and migration.
Journal of cellular biochemistry 2012;113(8):2597-606.
2012: Hong Cai; Colin N Chesterman; Beng H Chong; Miles P Davenport; Douglas J Francis; Gary M Halliday; Ross St C Barnetson; Graham J Lieschke; Ghassan J Maghzal; Fergal J Moloney; Christopher R Parish; Margaret Patrikakis; Leonel Prado-Lourenco; Fernando Santos Santiago; Roland Stocker; Bo Wang; Tak-Wah Wong; Levon M Khachigian
DNAzyme targeting c-jun suppresses skin cancer growth.
Science translational medicine 2012;4(139):139ra82.
2012: Levon M Khachigian; Fergal J Moloney; Christopher R Parish; Roland Stocker; Ross St C Barnetson; Hong Cai; Beng H Chong; Gary M Halliday
Destroying c-jun Messenger: new insights into biological mechanisms of DNAzyme function.
Oncotarget 2012;3(6):594-5.
2012: Kristine P Malabanan; Anjali V Sheahan; Levon M Khachigian
Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C.
The American journal of pathology 2012;180(6):2590-7.
2012: Ravinay Bhindi; Roger G Fahmy; Levon M Khachigian; Aisling C McMahon; Harry C Lowe
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
The Journal of pathology 2012;227(2):157-64.
2012: Ning Zhang; Estella Sanchez-Guerrero; Cecilia W S Chan; Levon M Khachigian
Repression of PDGF-R-α after cellular injury involves TNF-α, formation of a c-Fos-YY1 complex, and negative regulation by HDAC.
American journal of physiology. Cell physiology 2012;302(11):C1590-8.
2012: Hideto Ishii; Jian-Mei Li; Christopher R Parish; Fernando Santos Santiago; Mark D Hulett; Levon M Khachigian
Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
International journal of oncology 2012;40(5):1575-80.
2012: José Perdomo; Daniel R Carter; Xing-Mai Jiang; Levon M Khachigian; Beng H Chong
SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.
PloS one 2012;7(11):e50637.
2012: Cecilia W S Chan; Warren Kaplan; Christopher R Parish; Levon M Khachigian
Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme.
PloS one 2012;7(7):e39160.
2012: Estella Sanchez-Guerrero; Maaike Kockx; Si-Wei An; Elya Chen; Beng H Chong; Levon M Khachigian
IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM.
PloS one 2012;7(7):e39811.
2011: Megan P Hitchins; Levon M Khachigian; Chau-To Kwok; Patsie Polly; Robert W Rapkins; Sameer Srivastava; Jack Goldblatt; Justin J L Wong; Robyn L Ward
Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR.
Cancer cell 2011;20(2):200-13.
2011: S X Liang; S Liu; M Yang; Z Ahmadi; Levon M Khachigian; Beng H Chong
In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1+/CD31+ side-population cells).
Journal of thrombosis and haemostasis : JTH 2011;9(8):1628-37.
2011: Yue Li; Ravinay Bhindi; Levon M Khachigian
Recent developments in drug-eluting stents.
Journal of molecular medicine (Berlin, Germany) 2011;89(6):545-53.
2011: An Truong; Tien Y Wong; Levon M Khachigian
Emerging therapeutic approaches in the management of retinal angiogenesis and edema.
Journal of molecular medicine (Berlin, Germany) 2011;89(4):343-61.
2011: Melanie Murrell; Levon M Khachigian; Michael R Ward
Divergent roles of NF-κB and Egr-1 in flow-dependent restenosis after angioplasty and stenting.
Atherosclerosis 2011;214(1):65-72.
2010: Konstanze Beck; Ben J Wu; Jun Ni; Fernando Santos Santiago; Kristine P Malabanan; Cheng Li; Yutang Wang; Levon M Khachigian; Roland Stocker
Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia.
Circulation research 2010;107(12):1490-7.
2010: J Perdomo; E-L Fock; G Kaur; F Yan; Levon M Khachigian; David A Jans; Beng H Chong
A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production.
Journal of thrombosis and haemostasis : JTH 2010;8(11):2542-53.
2010: Jie Yu Ye; Godfrey Chi Fung Chan; Liang Qiao; Qizhou Lian; Fan-yi Meng; Xue Qun Luo; Levon M Khachigian; Ming Ma; Ruixia Deng; Jian Liang Chen; Beng H Chong; Mo Yang
Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway.
Haematologica 2010;95(10):1745-53.
2010: Simon X Liang; Mykola Pinkevych; Levon M Khachigian; Christopher R Parish; Miles P Davenport; Beng H Chong
Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG.
Blood 2010;116(11):1958-60.
2010: Robel Getachew; Mandy L Ballinger; Micah L Burch; Julianne J Reid; Levon M Khachigian; Thomas N Wight; Peter J Little; Narin Osman
PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.
Endocrinology 2010;151(9):4356-67.
2010: Qiang Cheng; Sonja J McKeown; Leilani Santos; Fernando Santos Santiago; Levon M Khachigian; Eric F Morand; Michael J Hickey
Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(2):1238-47.
2010: Mohammad H Pourgholami; Levon M Khachigian; Roger G Fahmy; Samina Badar; Lisa Wang; Stephanie Wai Ling Chu; David Lawson Morris
Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis.
Biochemical and biophysical research communications 2010;397(4):729-34.
2010: Kristine P Malabanan; Levon M Khachigian
Activation transcription factor-4 and the acute vascular response to injury.
Journal of molecular medicine (Berlin, Germany) 2010;88(6):545-52.
2010: Jeffrey Chan; Leonel Prado-Lourenco; Levon M Khachigian; Martin R Bennett; Belinda A Di Bartolo; Mary M Kavurma
TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner.
Circulation research 2010;106(6):1061-71.
2010: Bo Wang; Jinbiao Chen; Fernando Santos Santiago; Mary Janes; Mary M Kavurma; Beng H Chong; John E Pimanda; Levon M Khachigian
Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):536-45.
2010: Jun Ni; Alla Waldman; Levon M Khachigian
c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.
The Journal of biological chemistry 2010;285(6):4038-48.
2009: Mary Y Liu; Levon M Khachigian
Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and interferon regulatory factor-1.
The Journal of biological chemistry 2009;284(50):35101-12.
2009: Xiao Luo; Hong Cai; Jun Ni; Ravinay Bhindi; Harry C Lowe; Colin N Chesterman; Levon M Khachigian
c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1836-42.
2009: Ning Zhang; Levon M Khachigian
Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter.
The Journal of biological chemistry 2009;284(41):27933-43.
2009: Nicole Y Tan; Jian-Mei Li; Roland Stocker; Levon M Khachigian
Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement.
Circulation research 2009;105(5):422-30.
2009: Levon M Khachigian; Karlheinz Peter; Michael C Berndt
Recent advances in vascular biology: selected highlights from IVBM 2008.
Thrombosis and haemostasis 2009;101(6):997-8.
2009: Bo Wang; Levon M Khachigian; Luke Esau; Michael J Birrer; Xiaohang Zhao; M Iqbal Parker; Denver T Hendricks
A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer.
Molecular cancer research : MCR 2009;7(5):755-64.
2009: Nicole Y Tan; Levon M Khachigian
Sp1 phosphorylation and its regulation of gene transcription.
Molecular and cellular biology 2009;29(10):2483-8.
2009: C W S Chan; Levon M Khachigian
DNAzymes and their therapeutic possibilities.
Internal medicine journal 2009;39(4):249-51.
2009: Cuili Zhang; Q H Song; Levon M Khachigian; I Lubenec; Jue-Lon Shie; Baofeng Yang; Jian Li; Ye Tian
Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells.
Biochemical and biophysical research communications 2009;380(3):689-94.
2009: Nelly A Abdel-Malak; Mahroo Mofarrahi; Dominique Mayaki; Levon M Khachigian; Sabah N A Hussain
Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(2):209-16.
2008: Kristine P Malabanan; Peter Kanellakis; Alex Bobik; Levon M Khachigian
Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury.
Circulation research 2008;103(4):378-87.
2008: Crispin R Dass; Levon M Khachigian; Peter F M Choong
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Molecular cancer research : MCR 2008;6(8):1289-92.
2008: Crispin R Dass; Stuart J Galloway; Jonathan C M Clark; Levon M Khachigian; Peter F M Choong
Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy.
Cancer biology & therapy 2008;7(8):1297-301.
2008: Crispin R Dass; Levon M Khachigian; Peter F M Choong
c-Jun knockdown sensitizes osteosarcoma to doxorubicin.
Molecular cancer therapeutics 2008;7(7):1909-12.
2008: Crispin R Dass; Anna M Friedhuber; Levon M Khachigian; Dave E Dunstan; Peter F M Choong
Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model.
Cancer biology & therapy 2008;7(7):1033-6.
2008: Maria Kavallaris; Sarah J Meachem; Mark D Hulett; Catherine M West; Rachael E Pitt; Jennifer J Chesters; Warren S Laffan; Paul R Boreham; Levon M Khachigian
Perceptions in health and medical research careers: the Australian Society for Medical Research Workforce Survey.
The Medical journal of Australia 2008;188(9):520-4.
2008: Estella Sanchez-Guerrero; Valerie C Midgley; Levon M Khachigian
Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation.
Nucleic acids research 2008;36(6):1941-51.
2008: Mary M Kavurma; Michael Schoppet; Yuri V Bobryshev; Levon M Khachigian; Martin R Bennett
TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor.
The Journal of biological chemistry 2008;283(12):7754-62.
2008: Nicole Y Tan; Valerie C Midgley; Mary M Kavurma; Fernando Santos Santiago; Xiao Luo; Ryan Peden; Roger G Fahmy; Michael C Berndt; Mark P Molloy; Levon M Khachigian
Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.
Circulation research 2008;102(4):e38-51.
2008: Crispin R Dass; Peter F M Choong; Levon M Khachigian
DNAzyme technology and cancer therapy: cleave and let die.
Molecular cancer therapeutics 2008;7(2):243-51.
2007: Ravinay Bhindi; Roger G Fahmy; Harry C Lowe; Colin N Chesterman; Crispin R Dass; Murray J Cairns; Edward Saravolac; Lun-Quan Sun; Levon M Khachigian
Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.
The American journal of pathology 2007;171(4):1079-88.
2007: Mary M Kavurma; Nichola Figg; Martin R Bennett; John Mercer; Levon M Khachigian; Trevor D Littlewood
Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment.
The Biochemical journal 2007;407(1):79-87.
2007: Melanie Murrell; Levon M Khachigian; Michael R Ward
The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting.
Atherosclerosis 2007;194(2):364-71.
2007: Fernando Santos Santiago; Hideto Ishii; Shahida Shafi; Rohit Khurana; Peter Kanellakis; Ravinay Bhindi; Manfred J Ramirez; Alex Bobik; John F Martin; Colin N Chesterman; Ian Zachary; Levon M Khachigian
Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly.
Circulation research 2007;101(2):146-55.
2007: Vicky L Benson; Aisling C McMahon; Harry C Lowe; Levon M Khachigian
The streptozotocin-treated Sprague-Dawley rat: a useful model for the assessment of acute and chronic effects of myocardial ischaemia reperfusion injury in experimental diabetes.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(2):153-4.
2007: Roger G Fahmy; Levon M Khachigian
Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1.
Journal of cellular biochemistry 2007;100(6):1526-35.
2006: Guishui Zhang; X Luo; Eric Sumithran; Vernon S C Pua; Ross StC Barnetson; G M Halliday; Levon M Khachigian
Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression.
Oncogene 2006;25(55):7260-6.
2006: Ravinay Bhindi; Paul K Witting; Aisling C McMahon; Levon M Khachigian; Harry C Lowe
Rat models of myocardial infarction. Pathogenetic insights and clinical relevance.
Thrombosis and haemostasis 2006;96(5):602-10.
2006: Levon M Khachigian
Health and medical research funding: an investment in Australia's future.
The Medical journal of Australia 2006;185(7):348-9.
2006: Guishui Zhang; Roger G Fahmy; Nick diGirolamo; Levon M Khachigian
JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation.
Journal of cell science 2006;119(Pt 15):3219-26.
2006: Ravinay Bhindi; Levon M Khachigian; Harry C Lowe
DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats.
Journal of thrombosis and haemostasis : JTH 2006;4(7):1479-83.
2006: Roger G Fahmy; Alla Waldman; Guishui Zhang; Ainslie Mitchell; Nicodemus Tedla; Hong Cai; Carolyn R Geczy; Colin N Chesterman; Michael Perry; Levon M Khachigian
Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun.
Nature biotechnology 2006;24(7):856-63.
2006: Bronwyn A Kingwell; Gary P Anderson; Stephen J Duckett; Elizabeth A Hoole; Lisa R Jackson-Pulver; Levon M Khachigian; Meg E Morris; David M Roder; Jan Rothwell-Short; Andrew J Wilson
Evaluation of NHMRC funded research completed in 1992, 1997 and 2003: gains in knowledge, health and wealth.
The Medical journal of Australia 2006;184(6):282-6.
2006: Mary Yanxia Liu; Melanie Eyries; Chunyan Zhang; Fernando Santos Santiago; Levon M Khachigian
Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1.
Blood 2006;107(6):2322-9.
2006: Levon M Khachigian
Early growth response-1 in cardiovascular pathobiology.
Circulation research 2006;98(2):186-91.
2006: Levon M Khachigian
Collagen antibody-induced arthritis.
Nature protocols 2006;1(5):2512-6.
2005: Christian Fischer; Hugo Sanchez-Ruderisch; Martina Welzel; Bertram Wiedenmann; Toshiyuki Sakai; Sabine André; Hans-Joachim Gabius; Levon M Khachigian; Katharina M Detjen; Stefan Rosewicz
Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.
The Journal of biological chemistry 2005;280(44):37266-77.
2005: Amanda M de Mestre; Sudha Rao; June R Hornby; Thura Soe-Htwe; Levon M Khachigian; Mark D Hulett
Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
The Journal of biological chemistry 2005;280(42):35136-47.
2005: Michelle R Bonello; Yuri V Bobryshev; Levon M Khachigian
Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells.
The American journal of pathology 2005;167(4):1149-59.
2005: Levon M Khachigian
Suppressing a sick heart.
Nature medicine 2005;11(8):828-9.
2005: Mary M Kavurma; Ravinay Bhindi; Harry C Lowe; Colin N Chesterman; Levon M Khachigian
Vessel wall apoptosis and atherosclerotic plaque instability.
Journal of thrombosis and haemostasis : JTH 2005;3(3):465-72.
2005: Ravinay Bhindi; David Brieger; Hideto Ishii; Nick Di Girolamo; Rakesh K Kumar; Levon M Khachigian; Harry C Lowe
Fibroblast growth factor 2 and the transcription factor Egr-1 localise to endothelial cell microvascular channels in human coronary artery occlusion.
Thrombosis and haemostasis 2005;93(1):172-4.
2004: Colm G Hanratty; Melanie Murrell; Levon M Khachigian; Philip S Tsao; Michael R Ward
Low flow promotes instent intimal hyperplasia. Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate.
Atherosclerosis 2004;177(2):269-74.
2004: Mary M Kavurma; Levon M Khachigian
Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21(WAF1/Cip1) promoter.
Journal of cellular biochemistry 2004;93(5):904-16.
2004: Valerie C Midgley; Levon M Khachigian
Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1.
The Journal of biological chemistry 2004;279(39):40289-95.
2004: Levon M Khachigian
DNAzymes as molecular agents that manipulate Egr-1 gene expression.
Biochemical pharmacology 2004;68(6):1023-5.
2004: Fernando Santos Santiago; Levon M Khachigian
Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1.
Circulation research 2004;95(5):479-87.
2004: Levon M Khachigian
Deoxyribozymes as inhibitors of vascular smooth muscle cell growth.
Current pharmaceutical biotechnology 2004;5(4):337-9.
2004: Laveena Sharma; Els Melis; Michael J Hickey; Colin D Clyne; Jonathan Erlich; Levon M Khachigian; Piers Davenport; Eric F Morand; Peter Carmeliet; Peter G Tipping
The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia.
The American journal of pathology 2004;165(1):331-40.
2004: Guishui Zhang; Crispin R Dass; Eric Sumithran; Nick Di Girolamo; Lun-Quan Sun; Levon M Khachigian
Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents.
Journal of the National Cancer Institute 2004;96(9):683-96.
2004: Melanie Eyries; Tucker Collins; Levon M Khachigian
Modulation of growth factor gene expression in vascular cells by oxidative stress.
Endothelium : journal of endothelial cell research 2004;11(2):133-9.
2004: Michelle R Bonello; Levon M Khachigian
Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter.
The Journal of biological chemistry 2004;279(4):2377-82.
2004: Ainslie Mitchell; Crispin R Dass; Lun-Quan Sun; Levon M Khachigian
Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1.
Nucleic acids research 2004;32(10):3065-9.
2004: Roger G Fahmy; Levon M Khachigian
Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth.
Nucleic acids research 2004;32(7):2281-5.
2004: Levon M Khachigian; Christopher R Parish
Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies.
Cardiovascular drug reviews 2004;22(1):1-6.
2004: Levon M Khachigian
Early growth response-1: blocking angiogenesis by shooting the messenger.
Cell cycle (Georgetown, Tex.) 2004;3(1):10-1.
2003: Amanda M de Mestre; Levon M Khachigian; Fernando Santos Santiago; Maria A Staykova; Mark D Hulett
Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1.
The Journal of biological chemistry 2003;278(50):50377-85.
2003: Harry C Lowe; Ik-Kyung Jang; Levon M Khachigian
Animal models of vulnerable plaque. Clinical context and current status.
Thrombosis and haemostasis 2003;90(5):774-80.
2003: Catherine A Burkhart; Andy J Cheng; Janice Madafiglio; Maria Kavallaris; Mario Mili; Glenn M Marshall; William A Weiss; Levon M Khachigian; Murray D Norris; Michelle Haber
Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma.
Journal of the National Cancer Institute 2003;95(18):1394-403.
2003: Mary M Kavurma; Levon M Khachigian
Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation.
The Journal of biological chemistry 2003;278(35):32537-43.
2003: Roger G Fahmy; Crispin R Dass; Lun-Quan Sun; Colin N Chesterman; Levon M Khachigian
Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth.
Nature medicine 2003;9(8):1026-32.
2003: Cuili Zhang; Mary M Kavurma; Angela Lai; Levon M Khachigian
Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter.
The Journal of biological chemistry 2003;278(30):27903-9.
2003: John E Pimanda; Harry C Lowe; Philip J Hogg; Colin N Chesterman; Levon M Khachigian
Novel and emerging therapies in cardiology and haematology.
Current drug targets. Cardiovascular & haematological disorders 2003;3(2):101-23.
2003: Mary M Kavurma; Levon M Khachigian
ERK, JNK, and p38 MAP kinases differentially regulate proliferation and migration of phenotypically distinct smooth muscle cell subtypes.
Journal of cellular biochemistry 2003;89(2):289-300.
2003: Douglas J Francis; Christopher R Parish; Mark McGarry; Fernando Santos Santiago; Harry C Lowe; Kathryn J Brown; John A Bingley; Ian P Hayward; William B Cowden; Julie H Campbell; Gordon R Campbell; Colin N Chesterman; Levon M Khachigian
Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation.
Circulation research 2003;92(8):e70-7.
2003: Michael Eisbacher; Melissa L Holmes; Anthea Newton; Philip J Hogg; Levon M Khachigian; Merlin Crossley; Beng H Chong
Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding.
Molecular and cellular biology 2003;23(10):3427-41.
2003: Mary M Kavurma; Levon M Khachigian
Signaling and transcriptional control of Fas ligand gene expression.
Cell death and differentiation 2003;10(1):36-44.
2002: Mary M Kavurma; Yuri V Bobryshev; Levon M Khachigian
Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1.
The Journal of biological chemistry 2002;277(39):36244-52.
2002: Harry C Lowe; D Burkoff; Levon M Khachigian; Briain D MacNeill; Motoya Hayase; Stephen N Oesterle
Beyond angioplasty: novel developments in interventional cardiology.
Internal medicine journal 2002;32(9-10):470-4.
2002: Levon M Khachigian; Roger G Fahmy; Guishui Zhang; Yuri V Bobryshev; Anastasia Kaniaros
c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun.
The Journal of biological chemistry 2002;277(25):22985-91.
2002: Levon M Khachigian
DNAzymes: cutting a path to a new class of therapeutics.
Current opinion in molecular therapeutics 2002;4(2):119-21.
2002: Louise A Rafty; Fernando Santos Santiago; Levon M Khachigian
NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter.
The EMBO journal 2002;21(3):334-43.
2002: Harry C Lowe; Levon M Khachigian
Coating stents with antirestenotic drugs: the blunderbuss or the magic bullet?
Circulation 2002;105(4):E29.
2002: Harry C Lowe; Stephen N Oesterle; Levon M Khachigian
Coronary in-stent restenosis: current status and future strategies.
Journal of the American College of Cardiology 2002;39(2):183-93.
2002: Louise A Rafty; Levon M Khachigian
von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter.
Journal of cellular biochemistry 2002;85(3):490-5.
2002: Harry C Lowe; Colin N Chesterman; Levon M Khachigian
Catalytic antisense DNA molecules targeting Egr-1 inhibit neointima formation following permanent ligation of rat common carotid arteries.
Thrombosis and haemostasis 2002;87(1):134-40.
2002: Roger G Fahmy; Levon M Khachigian
Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury.
Journal of cellular biochemistry 2002;84(3):575-82.
2001: Fernando Santos Santiago; Levon M Khachigian
Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.
Journal of molecular medicine (Berlin, Germany) 2001;79(12):695-706.
2001: Levon M Khachigian
Catalytic oligonucleotides targeting EGR-1 as potential inhibitors of in-stent restenosis.
Annals of the New York Academy of Sciences 2001;947():412-5.
2001: Fernando Santos Santiago; Harry C Lowe; Yuri V Bobryshev; Levon M Khachigian
Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.
The Journal of biological chemistry 2001;276(44):41143-9.
2001: Harry C Lowe; Roger G Fahmy; Mary M Kavurma; A Baker; Colin N Chesterman; Levon M Khachigian
Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis.
Circulation research 2001;89(8):670-7.
2001: Harry C Lowe; R K Kumar; Colin N Chesterman; Roger G Fahmy; Levon M Khachigian
Coronary stent thrombosis: insights from the porcine coronary stent model.
Thrombosis and haemostasis 2001;86(3):937-8.
2001: Michael Eisbacher; Levon M Khachigian; T H Khin; Melissa L Holmes; Beng H Chong
Inducible expression of the megakaryocyte-specific gene glycoprotein IX is mediated through an Ets binding site and involves upstream activation of extracellular signal-regulated kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(8):435-45.
2001: Louise A Rafty; Levon M Khachigian
Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.
Nucleic acids research 2001;29(5):1027-33.
2001: Mary M Kavurma; Fernando Santos Santiago; E Bonfoco; Levon M Khachigian
Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement.
The Journal of biological chemistry 2001;276(7):4964-71.
2001: N Gousseva; K Kugathasan; Colin N Chesterman; Levon M Khachigian
Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury.
Journal of cellular biochemistry 2001;81(3):523-34.
2000: Levon M Khachigian
Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function.
The Journal of clinical investigation 2000;106(10):1189-95.
2000: L M Taylor; Levon M Khachigian
Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads.
The Journal of biological chemistry 2000;275(22):16709-16.
2000: R Sungaran; O T Chisholm; Boban Markovic; Levon M Khachigian; Y Tanaka; Beng H Chong
The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells.
Blood 2000;95(10):3094-101.
2000: Louise A Rafty; Levon M Khachigian
Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression.
The Journal of biological chemistry 2000;275(15):11478-83.
1999: Fernando Santos Santiago; Harry C Lowe; Mary M Kavurma; Colin N Chesterman; A Baker; D G Atkins; Levon M Khachigian
New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury.
Nature medicine 1999;5(11):1264-9.
1999: Fernando Santos Santiago; D G Atkins; Levon M Khachigian
Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr-1/NGFI-A-dependent.
The American journal of pathology 1999;155(3):897-905.
1999: F L Day; Louise A Rafty; Colin N Chesterman; Levon M Khachigian
Angiotensin II (ATII)-inducible platelet-derived growth factor A-chain gene expression is p42/44 extracellular signal-regulated kinase-1/2 and Egr-1-dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII antagonized by nitric oxide.
The Journal of biological chemistry 1999;274(34):23726-33.
1999: Levon M Khachigian; Fernando Santos Santiago; Louise A Rafty; O L Chan; G J Delbridge; Alex Bobik; T Collins; A C Johnson
GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.
Circulation research 1999;84(11):1258-67.
1999: Fernando Santos Santiago; Harry C Lowe; F L Day; Colin N Chesterman; Levon M Khachigian
Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2.
The American journal of pathology 1999;154(3):937-44.
1998: Levon M Khachigian; T Collins
Early growth response factor 1: a pleiotropic mediator of inducible gene expression.
Journal of molecular medicine (Berlin, Germany) 1998;76(9):613-6.
1998: Louise A Rafty; Levon M Khachigian
Zinc finger transcription factors mediate high constitutive platelet-derived growth factor-B expression in smooth muscle cells derived from aortae of newborn rats.
The Journal of biological chemistry 1998;273(10):5758-64.
1997: Levon M Khachigian; T Collins; J W Fries
N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo.
The American journal of pathology 1997;151(5):1225-9.
1997: Levon M Khachigian; T Collins
Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium.
Circulation research 1997;81(4):457-61.
1997: M Yang; Levon M Khachigian; C Hicks; Colin N Chesterman; Beng H Chong
Identification of PDGF receptors on human megakaryocytes and megakaryocytic cell lines.
Thrombosis and haemostasis 1997;78(2):892-6.
1997: G J Delbridge; Levon M Khachigian
FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1.
Circulation research 1997;81(2):282-8.
1996: SL Field; Levon M Khachigian; M J Sleigh; G Yang; S E Vandermark; Philip J Hogg; Colin N Chesterman
Extracellular matrix is a source of mitogenically active platelet-derived growth factor.
Journal of cellular physiology 1996;168(2):322-32.
1996: Levon M Khachigian; V Lindner; A J Williams; T Collins
Egr-1-induced endothelial gene expression: a common theme in vascular injury.
Science (New York, N.Y.) 1996;271(5254):1427-31.
1995: A S Neish; Levon M Khachigian; A Park; V R Baichwal; T Collins
Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1.
The Journal of biological chemistry 1995;270(48):28903-9.
1995: Levon M Khachigian; A J Williams; T Collins
Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells.
The Journal of biological chemistry 1995;270(46):27679-86.
1995: A J Williams; Levon M Khachigian; TB Shows; T Collins
Isolation and characterization of a novel zinc-finger protein with transcription repressor activity.
The Journal of biological chemistry 1995;270(38):22143-52.
1995: Levon M Khachigian; N Resnick; Michael A Gimbrone; T Collins
Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.
The Journal of clinical investigation 1995;96(2):1169-75.
1995: Levon M Khachigian; SL Field; R Crouch; Colin N Chesterman
Platelet-derived growth factor A-chain synthetic peptide inhibits human glioma xenograft proliferation in nude mice.
Anticancer research 1995;15(2):337-41.
1995: Levon M Khachigian; T Collins; J W Fries
Nuclear factor-kappa B mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells.
Biochemical and biophysical research communications 1995;206(2):462-7.
1994: Levon M Khachigian; J W Fries; M W Benz; D T Bonthron; T Collins
Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.
The Journal of biological chemistry 1994;269(36):22647-56.
1994: Levon M Khachigian; C N Chesterman
Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6.
Peptides 1994;15(1):133-7.
1993: Levon M Khachigian; Colin N Chesterman
Platelet-derived Growth Factor and its Receptor: Structure and Roles in Normal Growth and Pathology.
Platelets 1993;4(6):304-15.
1992: Levon M Khachigian; Colin N Chesterman
Synthetic peptides representing the alternatively spliced exon of the platelet-derived growth factor A-chain modulate mitogenesis stimulated by normal human serum and several growth factors.
The Journal of biological chemistry 1992;267(11):7478-82.
1992: Levon M Khachigian; DA Owensby; Colin N Chesterman
A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth factors.
The Journal of biological chemistry 1992;267(3):1660-6.
1991: Levon M Khachigian; G Evin; F J Morgan; DA Owensby; Colin N Chesterman
A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine.
Journal of immunological methods 1991;140(2):249-58.