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Ruoli Bai

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Taradas Sarkar; Zhi-Wei Su; Ruoli Bai; Rick Gussio; Jun Hao; Tam Luong Nguyen; Samuel X Qiu; Ernest Hamel
Interaction of pseudolaric acid B with the colchicine site of tubulin.
Demetrio Raffa; Benedetta Maggio; Fabiana Plescia; Stella Cascioferro; Salvatore Plescia; Maria Valeria Raimondi; Giuseppe Daidone; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Rosaria Maria Pipitone; Ruoli Bai; Ernest Hamel
Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides.
Ruoli Bai; James C Burnett; Rick Gussio; Murray H G Munro; Tam Luong Nguyen; George R Pettit; Amos B Smith; Onur Atasoylu; Ernest Hamel
Interactions of halichondrin B and eribulin with tubulin.

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All Publications

2012: Taradas Sarkar; Zhi-Wei Su; Ruoli Bai; Rick Gussio; Jun Hao; Tam Luong Nguyen; Samuel X Qiu; Ernest Hamel
Interaction of pseudolaric acid B with the colchicine site of tubulin.
Biochemical pharmacology 2012;84(4):444-50.
2011: Demetrio Raffa; Benedetta Maggio; Fabiana Plescia; Stella Cascioferro; Salvatore Plescia; Maria Valeria Raimondi; Giuseppe Daidone; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Rosaria Maria Pipitone; Ruoli Bai; Ernest Hamel
Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides.
European journal of medicinal chemistry 2011;46(7):2786-96.
2011: Ruoli Bai; James C Burnett; Rick Gussio; Murray H G Munro; Tam Luong Nguyen; George R Pettit; Amos B Smith; Onur Atasoylu; Ernest Hamel
Interactions of halichondrin B and eribulin with tubulin.
Journal of chemical information and modeling 2011;51(6):1393-404.
2010: Arun K Ghosh; Zachary L Dawson; Deuk Kyu Moon; Ruoli Bai; Ernest Hamel
Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs.
Bioorganic & medicinal chemistry letters 2010;20(17):5104-7.
2009: Giuseppe La Regina; Taradas Sarkar; Ruoli Bai; Michael Edler; Roberto Saletti; Antonio Coluccia; Francesco Piscitelli; Lara Minelli; Valerio Gatti; Carmela Mazzoccoli; Vanessa Palermo; cristina mazzoni; Claudio Falcone; Anna Scovassi; Vincenzo Giansanti; Pietro Campiglia; Amalia Porta; Bruno Maresca; Ernest Hamel; Andrea Brancale; Ettore Novellino; Romano Silvestri
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
Journal of medicinal chemistry 2009;52(23):7512-27.
2009: Michael Edler; Guangli Yang; M Katherine Jung; Ruoli Bai; William G Bornmann; Ernest Hamel
Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity.
Archives of biochemistry and biophysics 2009;487(2):98-104.
2009: Suwei Dong; Ernest Hamel; Ruoli Bai; David G Covell; John A Beutler; John A Porco
Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor.
Angewandte Chemie (International ed. in English) 2009;48(8):1494-7.
2008: RAVI ANCHOORI; Madeline Kortenhorst; Manuel Hidalgo; Taradas Sarkar; Gurulingappa Hallur; Ruoli Bai; Paulus van Diest; Ernest Hamel; Saeed R Khan
Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy.
Journal of medicinal chemistry 2008;51(19):5953-7.
2008: Ruoli Bai; Christopher D Vanderwal; J Fernando Díaz; Ernest Hamel
Interaction of a cyclostreptin analogue with the microtubule taxoid site: the covalent reaction rapidly follows binding.
Journal of natural products 2008;71(3):370-4.
2006: Donnette A Dabydeen; James C Burnett; Ruoli Bai; Pascal Verdier-Pinard; Sarah J H Hickford; George R Pettit; John W Blunt; Murray H G Munro; Rick Gussio; Ernest Hamel
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.
Molecular pharmacology 2006;70(6):1866-75.
2006: Pixu Li; Cory D Evans; Erin M Forbeck; Haengsoon Park; Ruoli Bai; Ernest Hamel; Madeleine M Joullié
Total synthesis and biological evaluation of ustiloxin natural products and two analogs.
Bioorganic & medicinal chemistry letters 2006;16(18):4804-7.
2005: Alexander V Statsuk; Ruoli Bai; Jeremy L Baryza; Vishal A Verma; Ernest Hamel; Paul A Wender; Sergey A Kozmin
Actin is the primary cellular receptor of bistramide A.
Nature chemical biology 2005;1(7):383-8.
2004: Ruoli Bai; David G Covell; George F Taylor; John A Kepler; Terry D Copeland; Nga Y Nguyen; George R Pettit; Ernest Hamel
Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12.
The Journal of biological chemistry 2004;279(29):30731-40.
2004: Eric J Gapud; Ruoli Bai; Arun K Ghosh; Ernest Hamel
Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.
Molecular pharmacology 2004;66(1):113-21.
2004: Demetrio Raffa; Michael Edler; Giuseppe Daidone; Benedetta Maggio; Mourad Merikech; Mourad Merickech; Salvatore Plescia; Domenico Schillaci; Ruoli Bai; Ernest Hamel
Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones.
European journal of medicinal chemistry 2004;39(4):299-304.
2003: Zobeida Cruz-Monserrate; Hélène C Vervoort; Ruoli Bai; David Newman; Stephen B Howell; Gerrit Los; Jeffrey T Mullaney; Michael D Williams; George R Pettit; William Fenical; Ernest Hamel
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
Molecular pharmacology 2003;63(6):1273-80.
2002: Ruoli Bai; Robert B Bates; Ernest Hamel; Richard E Moore; Pichaya Nakkiew; George R Pettit; Bilal A Sufi
Lyngbyastatin 1 and Ibu-epilyngbyastatin 1: synthesis, stereochemistry, and NMR line broadening.
Journal of natural products 2002;65(12):1824-9.
2002: Ruoli Bai; David G Covell; Chunfeng Liu; Arun K Ghosh; Ernest Hamel
(-)-Doliculide, a new macrocyclic depsipeptide enhancer of actin assembly.
The Journal of biological chemistry 2002;277(35):32165-71.
2002: Emmanuel A Ojo-Amaize; Emeka J Nchekwube; Howard B Cottam; Ruoli Bai; Pascal Verdier-Pinard; Vellalore N Kakkanaiah; Judith A Varner; Lorenzo Leoni; Joseph I Okogun; Akinbo A Adesomoju; Olusola A Oyemade; Ernest Hamel
Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action.
Cancer research 2002;62(14):4007-14.
2001: Ruoli Bai; Pascal Verdier-Pinard; S Gangwar; Chad C Stessman; K J McClure; Edward A Sausville; George R Pettit; Robert B Bates; Ernest Hamel
Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.
Molecular pharmacology 2001;59(3):462-9.
2000: Ruoli Bai; David G Covell; X F Pei; JB Ewell; Nga Y Nguyen; Arnold Brossi; Ernest Hamel
Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354.
The Journal of biological chemistry 2000;275(51):40443-52.
1999: Ruoli Bai; N A Durso; D L Sackett; Ernest Hamel
Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.
Biochemistry 1999;38(43):14302-10.
1999: Ruoli Bai; JB Ewell; Nga Y Nguyen; Ernest Hamel
Direct photoaffinity labeling of cysteine 211 or a nearby amino acid residue of beta-tubulin by guanosine 5'-diphosphate bound in the exchangeable site.
The Journal of biological chemistry 1999;274(18):12710-4.
1998: Ruoli Bai; K Choe; JB Ewell; Nga Y Nguyen; Ernest Hamel
Direct photoaffinity labeling of cysteine-295 of alpha-tubulin by guanosine 5'-triphosphate bound in the nonexchangeable site.
The Journal of biological chemistry 1998;273(16):9894-7.
1996: Ruoli Bai; R E Schwartz; J A Kepler; George R Pettit; E Hamel
Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.
Cancer research 1996;56(19):4398-406.
1996: Ruoli Bai; X F Pei; O Boyé; Z Getahun; S Grover; J Bekisz; Nga Y Nguyen; Arnold Brossi; E Hamel
Identification of cysteine 354 of beta-tubulin as part of the binding site for the A ring of colchicine.
The Journal of biological chemistry 1996;271(21):12639-45.
1995: George R Pettit; J K Srirangam; J Barkoczy; Michael D Williams; K P Durkin; Michael R Boyd; Ruoli Bai; E Hamel; Jean M Schmidt; Jean-Charles Chapuis
Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.
Anti-cancer drug design 1995;10(7):529-44.
1995: Ruoli Bai; G F Taylor; Zbigniew A Cichacz; C L Herald; J A Kepler; George R Pettit; E Hamel
The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
Biochemistry 1995;34(30):9714-21.
1995: Ruoli Bai; G F Taylor; Jean M Schmidt; M D Williams; J A Kepler; George R Pettit; E Hamel
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.
Molecular pharmacology 1995;47(5):965-76.
1993: Ruoli Bai; Zbigniew A Cichacz; C L Herald; George R Pettit; E Hamel
Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
Molecular pharmacology 1993;44(4):757-66.
1993: Ruoli Bai; M C Roach; S K Jayaram; J Barkoczy; George R Pettit; Richard Luduena; E Hamel
Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
Biochemical pharmacology 1993;45(7):1503-15.
1992: Ruoli Bai; S J Friedman; George R Pettit; E Hamel
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
Biochemical pharmacology 1992;43(12):2637-45.
1991: Ruoli Bai; KD Paull; C L Herald; L Malspeis; George R Pettit; E Hamel
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
The Journal of biological chemistry 1991;266(24):15882-9.
1990: Ruoli Bai; George R Pettit; E Hamel
Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
Biochemical pharmacology 1990;40(8):1859-64.
1990: Ruoli Bai; George R Pettit; E Hamel
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
The Journal of biological chemistry 1990;265(28):17141-9.
1990: Ruoli Bai; George R Pettit; E Hamel
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Biochemical pharmacology 1990;39(12):1941-9.
1989: Ruoli Bai; C M Lin; Nga Y Nguyen; T Y Liu; E Hamel
Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.
Biochemistry 1989;28(13):5606-12.
1989: Ruoli Bai; C Duanmu; E Hamel
Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: alkylation of sulfhydryl group(s) of beta-tubulin.
Biochimica et biophysica acta 1989;994(1):12-20.