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Daniel Khananshvili

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TOP 3
Liron Boyman; Daniel Khananshvili; Israel Sekler; George S B Williams; William Lederer
NCLX: The mitochondrial sodium calcium exchanger.
David Weisbrod; Anna Ziskind; Lili Barad; Ofer Binah; Nathan Dascal; Sivan Eliyahu; Joseph Itskovitz-Eldor; Daniel Khananshvili; Nataly Menaker; Shimrit Oz; Asher Peretz; Bernard Attali
SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.
Daniel Khananshvili
The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.

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All Publications

2013: Liron Boyman; Daniel Khananshvili; Israel Sekler; George S B Williams; William Lederer
NCLX: The mitochondrial sodium calcium exchanger.
Journal of molecular and cellular cardiology 2013;59():205-13.
2013: David Weisbrod; Anna Ziskind; Lili Barad; Ofer Binah; Nathan Dascal; Sivan Eliyahu; Joseph Itskovitz-Eldor; Daniel Khananshvili; Nataly Menaker; Shimrit Oz; Asher Peretz; Bernard Attali
SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):E1685-94.
2013: Daniel Khananshvili
The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Molecular aspects of medicine 2013;34(2-3):220-35.
2013: Moshe Giladi; Daniel Khananshvili
Molecular determinants of allosteric regulation in NCX proteins.
Advances in experimental medicine and biology 2013;961():35-48.
2012: Moshe Giladi; Reuben Hiller; Xianyang Fang; Itay Friedberg; Yun-Xing Wang; Daniel Khananshvili
G503 is obligatory for coupling of regulatory domains in NCX proteins.
Biochemistry 2012;51(37):7313-20.
2012: Moshe Giladi; Reuben Hiller; Hilla Bohbot; Tal Buki; Dan H Schulze; Daniel Khananshvili
Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.
Cell calcium 2012;51(6):478-85.
2012: Iulia I Nita; Eyal Ozeri; Guy A Rutter; Daniel Fishman; Michal Hershfinkel; Daniel Khananshvili; Eli C Lewis; Stefano L Sensi; Israel Sekler
The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.
PloS one 2012;7(10):e46649.
2012: Moshe Giladi; Reuben Hiller; Joel A Hirsch; Tal Buki; Xianyang Fang; Yehezkel Sasson; Yun-Xing Wang; Daniel Khananshvili
A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
PloS one 2012;7(6):e39985.
2011: Liron Boyman; Moshe Giladi; Brian Hagen; Reuben Hiller; W Jonathan Lederer; Daniel Khananshvili
Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger.
The Journal of biological chemistry 2011;286(33):28811-20.
2010: Moshe Giladi; Liron Boyman; Helen Mikhasenko; Reuben Hiller; Daniel Khananshvili
Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.
The Journal of biological chemistry 2010;285(36):28117-25.
2010: Raz Palty; William F Silverman; Michal Hershfinkel; Teresa Caporale; Stefano L Sensi; Julia Parnis; Christiane Nolte; Daniel Fishman; Varda Shoshan-Barmatz; Sharon Herrmann; Daniel Khananshvili; Israel Sekler
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):436-41.
2009: Liron Boyman; Helen Mikhasenko; Reuben Hiller; Daniel Khananshvili
Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein.
The Journal of biological chemistry 2009;284(10):6185-93.
2008: Liron Boyman; Reuben Hiller; W Jonathan Lederer; Daniel Khananshvili
Direct Loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein.
Biochemistry 2008;47(25):6602-11.
2006: Beni Shpak; Yana Gofman; Chagit Shpak; Reuben Hiller; Liron Boyman; Daniel Khananshvili
Effects of purified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig.
European journal of pharmacology 2006;553(1-3):196-204.
2006: Raz Palty; Michal Hershfinkel; Oren Yagev; Drorit Saar; Ronit Barkalifa; Daniel Khananshvili; Asher Peretz; Yoram Grossman; Israel Sekler
Single alpha-domain constructs of the Na+/Ca2+ exchanger, NCLX, oligomerize to form a functional exchanger.
Biochemistry 2006;45(39):11856-66.
2006: Boyman Liron; Hiller Reuben; Shpak Beni; Shpak Chagit; Daniel Khananshvili
Purified endogenous inhibitor of the Na/Ca exchanger can enhance the cardiomyocytes contractility and calcium transients.
Biochemical and biophysical research communications 2006;346(3):1100-7.
2005: Liron Boyman; Reuben Hiller; Beni Shpak; Erika Yomtov; Chagit Shpak; Daniel Khananshvili
Advanced procedures for separation and analysis of low molecular weight inhibitor (NCXIF) of the cardiac sodium-calcium exchanger.
Biochemical and biophysical research communications 2005;337(3):936-43.
2004: Chagit Shpak; Reuben Hiller; Beni Shpak; Liron Boyman; Daniel Khananshvili
The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion-transport site of the Na/Ca exchanger.
Biochemical and biophysical research communications 2004;324(4):1346-51.
2004: Beni Shpak; Chagit Shpak; Reuben Hiller; Liron Boyman; Daniel Khananshvili
Inotropic and lusitropic effects induced by the inhibitory factor of the Na/Ca exchanger are not mediated by the beta-adrenergic activation.
Journal of cardiovascular pharmacology 2004;44(4):466-72.
2003: Chagit Shpak; Reuben Hiller; Beni Shpak; Daniel Khananshvili
The endogenous inhibitor of NCX1 does not resemble the properties of digitalis compound.
Biochemical and biophysical research communications 2003;308(1):114-9.
2000: Reuben Hiller; Chagit Shpak; G Shavit; Beni Shpak; Daniel Khananshvili
An unknown endogenous inhibitor of Na/Ca exchange can enhance the cardiac muscle contractility.
Biochemical and biophysical research communications 2000;277(1):138-46.
1999: D Baazov; X Wang; Daniel Khananshvili
Time-resolved monitoring of electrogenic Na+-Ca2+ exchange in the isolated cardiac sarcolemma vesicles by using a rapid-response fluorescent probe.
Biochemistry 1999;38(5):1435-45.
1997: Daniel Khananshvili; B Mester; M Saltoun; X Wang; G Shaulov; D Baazov
Inhibition of the cardiac sarcolemma Na+/Ca2+ exchanger by conformationally constrained small cyclic peptides.
Molecular pharmacology 1997;51(1):126-31.
1996: Daniel Khananshvili; D Baazov; E Weil-Maslansky; G Shaulov; B Mester
Rapid interaction of FRCRCFa with the cytosolic side of the cardiac sarcolemma Na(+)-Ca2+ exchanger blocks the ion transport without preventing the binding of either sodium or calcium.
Biochemistry 1996;35(49):15933-40.
1996: Daniel Khananshvili; E Weil-Maslansky; D Baazov
Kinetics and mechanism: modulation of ion transport in the cardiac sarcolemma sodium-calcium exchanger by protons, monovalent, ions, and temperature.
Annals of the New York Academy of Sciences 1996;779():217-35.
1995: Daniel Khananshvili; G Shaulov; E Weil-Maslansky
Rate-limiting mechanisms of exchange reactions in the cardiac sarcolemma Na(+)-Ca2+ exchanger.
Biochemistry 1995;34(32):10290-7.
1995: Daniel Khananshvili; G Shaulov; E Weil-Maslansky; D Baazov
Positively charged cyclic hexapeptides, novel blockers for the cardiac sarcolemma Na(+)-Ca2+ exchanger.
The Journal of biological chemistry 1995;270(27):16182-8.
1994: Daniel Khananshvili; E Weil-Maslansky
The cardiac Na(+)-Ca2+ exchanger: relative rates of calcium and sodium movements and their modulation by protonation-deprotonation of the carrier.
Biochemistry 1994;33(1):312-9.
1993: Daniel Khananshvili; D C Price; M J Greenberg; Yosef Sarne
Phe-Met-Arg-Phe-NH2 (FMRFa)-related peptides inhibit Na(+)-Ca2+ exchange in cardiac sarcolemma vesicles.
The Journal of biological chemistry 1993;268(1):200-5.
1992: Daniel Khananshvili; Yosef Sarne
The effect of opiate agonists and antagonists on Na(+)-Ca2+ exchange in cardiac sarcolemma vesicles.
Life sciences 1992;51(4):275-83.
1991: Daniel Khananshvili
Voltage-dependent modulation of ion binding and translocation in the cardiac Na(+)-Ca2+ exchange system.
The Journal of biological chemistry 1991;266(21):13764-9.
1991: Daniel Khananshvili
Mechanism of partial reactions in the cardiac Na(+)-Ca2+ exchange system.
Annals of the New York Academy of Sciences 1991;639():85-95.
1990: Daniel Khananshvili
Cation antiporters.
Current opinion in cell biology 1990;2(4):731-4.
1990: Daniel Khananshvili
Distinction between the two basic mechanisms of cation transport in the cardiac Na(+)-Ca2+ exchange system.
Biochemistry 1990;29(10):2437-42.