Kum Kum Khanna

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van der Horst Armando; Simmons Jacinta; Khanna Kum Kum
Cep55 stabilization is required for normal execution of cytokinesis.
Bolderson Emma; Richard Derek J; Zhou Bin-Bing S; Khanna Kum Kum
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.
Skaar Jeffrey R; Richard Derek J; Saraf Anita; Toschi Alfredo; Bolderson Emma; Florens Laurence; Washburn Michael P; Khanna Kum Kum; Pagano Michele
INTS3 controls the hSSB1-mediated DNA damage response.

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All Publications

2009: van der Horst Armando; Simmons Jacinta; Khanna Kum Kum
Cep55 stabilization is required for normal execution of cytokinesis.
Cell cycle (Georgetown, Tex.) 2009;8(22):3742-9.
2009: Bolderson Emma; Richard Derek J; Zhou Bin-Bing S; Khanna Kum Kum
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(20):6314-20.
2009: Skaar Jeffrey R; Richard Derek J; Saraf Anita; Toschi Alfredo; Bolderson Emma; Florens Laurence; Washburn Michael P; Khanna Kum Kum; Pagano Michele
INTS3 controls the hSSB1-mediated DNA damage response.
The Journal of cell biology 2009;187(1):25-32.
2009: Di Cosmo Caterina; McLellan Neil; Liao Xiao-Hui; Khanna Kum Kum; Weiss Roy E; Papp Laura; Refetoff Samuel
Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X).
The Journal of clinical endocrinology and metabolism 2009;94(10):4003-9.
2009: van der Horst Armando; Khanna Kum Kum
The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55.
Cancer research 2009;69(16):6651-9.
2009: Li Yongjiang; Bolderson Emma; Kumar Rakesh; Muniandy Parameswary A; Xue Yutong; Richard Derek J; Seidman Michael; Pandita Tej K; Khanna Kum Kum; Wang Weidong
HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.
The Journal of biological chemistry 2009;284(35):23525-31.
2009: Gupta Arun; Yang Qin; Pandita Raj K; Hunt Clayton R; Xiang Tao; Misri Sandeep; Zeng Sicong; Pagan Julia; Jeffery Jessei; Puc Janusz; Kumar Rakesh; Feng Zhihui; Powell Simon N; Bhat Audesh; Yaguchi Tomoko; Wadhwa Renu; Kaul Sunil C; Parsons Ramon; Khanna Kum Kum; Pandita Tej K
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.
Cell cycle (Georgetown, Tex.) 2009;8(14):2198-210.
2009: Bolderson Emma; Richard Derek J; Edelmann Winfried; Khanna Kum Kum
Involvement of Exo1b in DNA damage-induced apoptosis.
Nucleic acids research 2009;37(10):3452-63.
2009: Chircop Megan; Oakes Vanessa; Graham Mark E; Ma Maggie P C; Smith Charlotte M; Robinson Phillip J; Khanna Kum Kum
The actin-binding and bundling protein, EPLIN, is required for cytokinesis.
Cell cycle (Georgetown, Tex.) 2009;8(5):757-64.
2008: Richard Derek J; Bolderson Emma; Cubeddu Liza; Wadsworth Ross I M; Savage Kienan; Sharma Girdhar G; Nicolette Matthew L; Tsvetanov Sergie; McIlwraith Michael J; Pandita Raj K; Takeda Shunichi; Hay Ronald T; Gautier Jean; West Stephen C; Paull Tanya T; Pandita Tej K; White Malcolm F; Khanna Kum Kum
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Nature 2008;453(7195):677-81.
2007: Marsh Anna; Healey Sue; Lewis Aaron; Spurdle Amanda B; Kedda Mary Anne; Khanna Kum Kum; Mann Graham J; Pupo Gulietta M; Lakhani Sunil R; Chenevix-Trench Georgia
Mutation analysis of five candidate genes in familial breast cancer.
Breast cancer research and treatment 2007;105(3):377-89.
2007: Papp Laura Vanda; Lu Jun; Holmgren Arne; Khanna Kum Kum
From selenium to selenoproteins: synthesis, identity, and their role in human health.
Antioxidants & redox signaling 2007;9(7):775-806.
2007: Pagan Julia K; Arnold Jeremy; Hanchard Kim J; Kumar Raman; Bruno Tiziana; Jones Mathew J K; Richard Derek J; Forrest Alistair; Spurdle Amanda; Verdin Eric; Crossley Merlin; Fanciulli Maurizio; Chenevix-Trench Georgia; Young David B; Khanna Kum Kum
A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.
The Journal of biological chemistry 2007;282(20):15248-57.
2007: Pylkäs Katri; Tommiska Johanna; Syrjäkoski Kirsi; Kere Juha; Gatei Magtouf; Waddell Nicola; Allinen Minna; Karppinen Sanna-Maria; Rapakko Katrin; Kääriäinen Helena; Aittomäki Kristiina; Blomqvist Carl; Mustonen Aki; Holli Kaija; Khanna Kum Kum; Kallioniemi Olli-Pekka; Nevanlinna Heli; Winqvist Robert
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
Carcinogenesis 2007;28(5):1040-5.
2007: Lose Felicity; Arnold Jeremy; Young David B; Brown Carolyn J; Mann Graham J; Pupo Gulietta M; Khanna Kum Kum; Chenevix-Trench Georgia; Spurdle Amanda B
BCoR-L1 variation and breast cancer.
Breast cancer research : BCR 2007;9(4):R54.
2006: Bruno Tiziana; De Nicola Francesca; Iezzi Simona; Lecis Daniele; D'Angelo Carmen; Di Padova Monica; Corbi Nicoletta; Dimiziani Leopoldo; Zannini Laura; Jekimovs Christian; Scarsella Marco; Porrello Alessandro; Chersi Alberto; Crescenzi Marco; Leonetti Carlo; Khanna Kum Kum; Soddu Silvia; Floridi Aristide; Passananti Claudio; Delia Domenico; Fanciulli Maurizio
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
Cancer cell 2006;10(6):473-86.
2006: Henderson Michelle J; Munoz Marcia A; Saunders Darren N; Clancy Jennifer L; Russell Amanda J; Williams Brandi; Pappin Darryl; Khanna Kum Kum; Jackson Stephen P; Sutherland Robert L; Watts Colin K W
EDD mediates DNA damage-induced activation of CHK2.
The Journal of biological chemistry 2006;281(52):39990-40000.
2006: Waddell Nic; Jonnalagadda Jyoti; Marsh Anna; Grist Scott; Jenkins Mark; Hobson Karen; Taylor Malcolm; Lindeman Geoff J; Tavtigian Sean V; Suthers Graeme; Goldgar David; Oefner Peter J; Taylor Darrin; Grimmond Sean; Khanna Kum Kum; Chenevix-Trench Georgia
Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling.
Genes, chromosomes & cancer 2006;45(12):1169-81.
2006: Deans Andrew J; Khanna Kum Kum; McNees Carolyn J; Mercurio Ciro; Heierhorst Jörg; McArthur Grant A
Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers.
Cancer research 2006;66(16):8219-26.
2006: Papp Laura V; Lu Jun; Striebel Frank; Kennedy Derek; Holmgren Arne; Khanna Kum Kum
The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function.
Molecular and cellular biology 2006;26(13):4895-910.
2006: Kang Hyo Jin; Kim Hee Jeong; Kim Sang Keun; Barouki Robert; Cho Chi-Heum; Khanna Kum Kum; Rosen Eliot M; Bae Insoo
BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells.
The Journal of biological chemistry 2006;281(21):14654-62.
2006: Khanna Kum Kum; Gatei Magtouf; Tribbick Gordon
Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage.
Methods in molecular medicine 2006;120():441-52.
2005: Jung Cha-Gyun; Kim Hye-Jung; Kawaguchi Makoto; Khanna Kum Kum; Hida Hideki; Asai Kiyofumi; Nishino Hitoo; Miura Yutaka
Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation.
Development (Cambridge, England) 2005;132(23):5137-45.
2005: Fabbro Megan; Zhou Bin-Bing; Takahashi Mikiko; Sarcevic Boris; Lal Preeti; Graham Mark E; Gabrielli Brian G; Robinson Phillip J; Nigg Erich A; Ono Yoshitaka; Khanna Kum Kum
Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.
Developmental cell 2005;9(4):477-88.
2005: Young David B; Jonnalagadda Jyoti; Gatei Magtouf; Jans David A; Meyn Stephen; Khanna Kum Kum
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
The Journal of biological chemistry 2005;280(30):27587-94.
2005: Gupta Arun; Sharma Girdhar G; Young Charles S H; Agarwal Manjula; Smith Edwin R; Paull Tanya T; Lucchesi John C; Khanna Kum Kum; Ludwig Thomas; Pandita Tej K
Involvement of human MOF in ATM function.
Molecular and cellular biology 2005;25(12):5292-305.
2005: Thompson Deborah; Antoniou Antonis C; Jenkins Mark; Marsh Anna; Chen Xiaoqing; Wayne Tierney; Tesoriero Andrea; Milne Roger; Spurdle Amanda; Thorstenson Yvonne; Southey Melissa; Giles Graham G; Khanna Kum Kum; Sambrook Joseph; Oefner Peter; Goldgar David; Hopper John L; Easton Doug; Chenevix-Trench Georgia;
Two ATM variants and breast cancer risk.
Human mutation 2005;25(6):594-5.
2005: Jekimovs C R; Chen X; Arnold J; Gatei M; Richard D J; Spurdle A B; Khanna K K; Chenevix-Trench G;
Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals.
British journal of cancer 2005;92(4):784-90.
2004: Goodarzi Aaron A; Jonnalagadda Jyoti C; Douglas Pauline; Young David; Ye Ruiqiong; Moorhead Greg B G; Lees-Miller Susan P; Khanna Kum Kum
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
The EMBO journal 2004;23(22):4451-61.
2004: Buscemi Giacomo; Perego Paola; Carenini Nives; Nakanishi Makoto; Chessa Luciana; Chen Junjie; Khanna Kumkum; Delia Domenico
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.
Oncogene 2004;23(46):7691-700.
2004: Khanna Kum Kum; Chenevix-Trench Georgia
ATM and genome maintenance: defining its role in breast cancer susceptibility.
Journal of mammary gland biology and neoplasia 2004;9(3):247-62.
2004: Fabbro Megan; Savage Kienan; Hobson Karen; Deans Andrew J; Powell Simon N; McArthur Grant A; Khanna Kum Kum
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
The Journal of biological chemistry 2004;279(30):31251-8.
2003: Krause Darren R; Jonnalagadda Jyoti C; Gatei Magtouf H; Sillje Herman H W; Zhou Bin-Bing; Nigg Erich A; Khanna Kumkum
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
Oncogene 2003;22(38):5927-37.
2003: Gatei Magtouf; Sloper Katie; Sorensen Claus; Syljuäsen Randi; Falck Jacob; Hobson Karen; Savage Kienan; Lukas Jiri; Zhou Bin-Bing; Bartek Jiri; Khanna Kum Kum
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
The Journal of biological chemistry 2003;278(17):14806-11.
2003: Sørensen Claus Storgaard; Syljuåsen Randi G; Falck Jacob; Schroeder Tine; Rönnstrand Lars; Khanna Kum Kum; Zhou Bin-Bing; Bartek Jiri; Lukas Jiri
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Cancer cell 2003;3(3):247-58.
2003: Zhou Bin-Bing S; Mattern Michael R; Khanna Kum Kum
Role of tumor suppressors in DNA damage response.
Methods in molecular biology (Clifton, N.J.) 2003;223():39-50.
2002: Brown Melissa A; Nicolai Hans; Howe Kathy; Katagiri Toyomasa; Lalani El-Nasir; Simpson Kaylene J; Manning Nathan W; Deans Andrew; Chen Phil; Khanna Kum Kum; Wati Mas Rina; Griffiths Beatrice L; Xu Chun-Fang; Stamp Gordon W H; Solomon Ellen
Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice.
Transgenic research 2002;11(5):467-78.
2002: Chenevix-Trench Georgia; Spurdle Amanda B; Gatei Magtouf; Kelly Helena; Marsh Anna; Chen Xiaoqing; Donn Karen; Cummings Margaret; Nyholt Dale; Jenkins Mark A; Scott Clare; Pupo Gulietta M; Dörk Thilo; Bendix Regina; Kirk Judy; Tucker Katherine; McCredie Margaret R E; Hopper John L; Sambrook Joseph; Mann Graham J; Khanna Kum Kum
Dominant negative ATM mutations in breast cancer families.
Journal of the National Cancer Institute 2002;94(3):205-15.
2001: Khanna K K; Lavin M F; Jackson S P; Mulhern T D
ATM, a central controller of cellular responses to DNA damage.
Cell death and differentiation 2001;8(11):1052-65.
2001: Buscemi G; Savio C; Zannini L; Miccichè F; Masnada D; Nakanishi M; Tauchi H; Komatsu K; Mizutani S; Khanna K; Chen P; Concannon P; Chessa L; Delia D
Chk2 activation dependence on Nbs1 after DNA damage.
Molecular and cellular biology 2001;21(15):5214-22.
2001: Gatei M; Zhou B B; Hobson K; Scott S; Young D; Khanna K K
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
The Journal of biological chemistry 2001;276(20):17276-80.
2001: Khanna K K; Jackson S P
DNA double-strand breaks: signaling, repair and the cancer connection.
Nature genetics 2001;27(3):247-54.
2001: Gueven N; Keating K E; Chen P; Fukao T; Khanna K K; Watters D; Rodemann P H; Lavin M F
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
The Journal of biological chemistry 2001;276(12):8884-91.
2001: Ye R; Bodero A; Zhou B B; Khanna K K; Lavin M F; Lees-Miller S P
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
The Journal of biological chemistry 2001;276(7):4828-33.
2001: Fillippovich I; Sorokina N; Gatei M; Haupt Y; Hobson K; Moallem E; Spring K; Mould M; McGuckin M A; Lavin M F; Khanna K K
Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.
Oncogene 2001;20(4):514-22.
2001: Gatei M; Shkedy D; Khanna K K; Uziel T; Shiloh Y; Pandita T K; Lavin M F; Rotman G
Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid.
Oncogene 2001;20(3):289-94.
2000: Gatei M; Scott S P; Filippovitch I; Soronika N; Lavin M F; Weber B; Khanna K K
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
Cancer research 2000;60(12):3299-304.
2000: Khanna K K
Cancer risk and the ATM gene: a continuing debate.
Journal of the National Cancer Institute 2000;92(10):795-802.
2000: Gatei M; Young D; Cerosaletti K M; Desai-Mehta A; Spring K; Kozlov S; Lavin M F; Gatti R A; Concannon P; Khanna K
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Nature genetics 2000;25(1):115-9.
2000: Zhou B B; Chaturvedi P; Spring K; Scott S P; Johanson R A; Mishra R; Mattern M R; Winkler J D; Khanna K K
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.
The Journal of biological chemistry 2000;275(14):10342-8.
2000: Chan D W; Son S C; Block W; Ye R; Khanna K K; Wold M S; Douglas P; Goodarzi A A; Pelley J; Taya Y; Lavin M F; Lees-Miller S P
Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase.
The Journal of biological chemistry 2000;275(11):7803-10.
1999: Imyanitov E N; Birrell G W; Filippovich I; Sorokina N; Arnold J; Mould M A; Wright K; Walsh M; Mok S C; Lavin M F; Chenevix-Trench G; Khanna K K
Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target.
Oncogene 1999;18(32):4640-2.
1999: Chen P; Gatei M; O'Connell M J; Khanna K K; Bugg S J; Hogg A; Scott S P; Hobson K; Lavin M F
Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells.
Oncogene 1999;18(1):249-56.
1998: Waterhouse N J; Finucane D M; Green D R; Elce J S; Kumar S; Alnemri E S; Litwack G; Khanna K; Lavin M F; Watters D J
Calpain activation is upstream of caspases in radiation-induced apoptosis.
Cell death and differentiation 1998;5(12):1051-61.
1998: Khanna K K; Keating K E; Kozlov S; Scott S; Gatei M; Hobson K; Taya Y; Gabrielli B; Chan D; Lees-Miller S P; Lavin M F
ATM associates with and phosphorylates p53: mapping the region of interaction.
Nature genetics 1998;20(4):398-400.
1998: Zhang N; Chen P; Gatei M; Scott S; Khanna K K; Lavin M F
An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells.
Oncogene 1998;17(7):811-8.
1998: Scott S P; Zhang N; Khanna K K; Khromykh A; Hobson K; Watters D; Lavin M F
Cloning and expression of the ataxia-telangiectasia gene in baculovirus.
Biochemical and biophysical research communications 1998;245(1):144-8.
1997: Zhang N; Chen P; Khanna K K; Scott S; Gatei M; Kozlov S; Watters D; Spring K; Yen T; Lavin M F
Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8021-6.
1997: Shafman T; Khanna K K; Kedar P; Spring K; Kozlov S; Yen T; Hobson K; Gatei M; Zhang N; Watters D; Egerton M; Shiloh Y; Kharbanda S; Kufe D; Lavin M F
Interaction between ATM protein and c-Abl in response to DNA damage.
Nature 1997;387(6632):520-3.
1997: Watters D; Khanna K K; Beamish H; Birrell G; Spring K; Kedar P; Gatei M; Stenzel D; Hobson K; Kozlov S; Zhang N; Farrell A; Ramsay J; Gatti R; Lavin M
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Oncogene 1997;14(16):1911-21.
1997: Khanna K K; Yan J; Watters D; Hobson K; Beamish H; Spring K; Shiloh Y; Gatti R A; Lavin M F
Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells.
The Journal of biological chemistry 1997;272(14):9489-95.
1996: Beamish H; Williams R; Chen P; Khanna K K; Hobson K; Watters D; Shiloh Y; Lavin M
Rapamycin resistance in ataxia-telangiectasia.
Oncogene 1996;13(5):963-70.
1996: Khanna K K; Wie T; Song Q; Burrows S R; Moss D J; Krajewski S; Reed J C; Lavin M F
Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells.
Cell death and differentiation 1996;3(3):315-22.
1996: Song Q; Lees-Miller S P; Kumar S; Zhang Z; Chan D W; Smith G C; Jackson S P; Alnemri E S; Litwack G; Khanna K K; Lavin M F
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
The EMBO journal 1996;15(13):3238-46.
1996: Yan J; Khanna K K; Lavin M F
Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.
International journal of radiation biology 1996;69(5):539-46.
1996: Chen P; Girjes A A; Hobson K; Beamish H; Khanna K K; Farrell A; Gatei M; Teale B; Buchwald M; Legerski R; Lavin M F
Genetic complementation of radiation response by 3' untranslated regions (UTR) of RNA.
International journal of radiation biology 1996;69(3):385-95.
1995: Lavin M F; Khanna K K; Beamish H; Spring K; Watters D; Shiloh Y
Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase.
Trends in biochemical sciences 1995;20(10):382-3.
1995: Khanna K K; Beamish H; Yan J; Hobson K; Williams R; Dunn I; Lavin M F
Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia.
Oncogene 1995;11(4):609-18.
1994: Lavin M F; Khanna K K; Beamish H; Teale B; Hobson K; Watters D
Defect in radiation signal transduction in ataxia-telangiectasia.
International journal of radiation biology 1994;66(6 Suppl):S151-6.
1994: Beamish H; Khanna K K; Lavin M F
Ionizing radiation and cell cycle progression in ataxia telangiectasia.
Radiation research 1994;138(1 Suppl):S130-3.
1994: Filippovich I; Sorokina N; Khanna K K; Lavin M F
Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA.
Biochemical and biophysical research communications 1994;198(1):257-65.
1993: Khanna K K; Lavin M F
Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.
Oncogene 1993;8(12):3307-12.
1993: Teale B; Khanna K K; Singh S P; Lavin M F
Radiation-activated DNA-binding protein constitutively present in ataxia telangiectasia nuclei.
The Journal of biological chemistry 1993;268(30):22450-5.
1992: Teale B; Singh S; Khanna K K; Findik D; Lavin M F
Purification and characterization of a DNA-binding protein activated by ionizing radiation.
The Journal of biological chemistry 1992;267(15):10295-301.

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