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Rajiv Khanna

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Deborah Cromer; Rajiv Khanna; Siok-Keen Tey; Miles P Davenport
Estimating cytomegalovirus growth rates by using only a single point.
C Smith; Rajiv Khanna
Immune regulation of human herpesviruses and its implications for human transplantation.
Judy T Tellam; Jie Zhong; Lea Lekieffre; David J Lynn; Rajiv Khanna
Messenger RNA sequence rather than protein sequence determines the level of self-synthesis and antigen presentation of the EBV-encoded antigen, EBNA1.

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All Publications

2013: Deborah Cromer; Rajiv Khanna; Siok-Keen Tey; Miles P Davenport
Estimating cytomegalovirus growth rates by using only a single point.
Journal of virology 2013;87(6):3376-81.
2013: C Smith; Rajiv Khanna
Immune regulation of human herpesviruses and its implications for human transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013;13 Suppl 3():9-23; quiz 23.
2012: Judy T Tellam; Jie Zhong; Lea Lekieffre; David J Lynn; Rajiv Khanna
Messenger RNA sequence rather than protein sequence determines the level of self-synthesis and antigen presentation of the EBV-encoded antigen, EBNA1.
PLoS pathogens 2012;8(12):e1003112.
2012: Siok-Keen Tey; Rajiv Khanna
Host immune system strikes back: autophagy-mediated antigen presentation bypasses viral blockade of the classic MHC class I processing pathway.
Autophagy 2012;8(12):1839-41.
2012: Corey Smith; Ross Tellam; Siok-Keen Tey; Katherine K Wynn; Scott R Burrows; Vijayendra Dasari; Diah Elhassen; Stephanie Gras; Yu Chih Liu; Sweera Rehan; Jamie Rossjohn; Rajiv Khanna
Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells.
Blood 2012;120(16):3237-45.
2012: Tania Crough; Linda Jones; Corey Smith; David G Walker; Leone Beagley; Rajiv Khanna
Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirus-specific T-cells in patients with glioblastoma multiforme.
Immunology and cell biology 2012;90(9):872-80.
2012: Siok-Keen Tey; Rajiv Khanna
Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway.
Blood 2012;120(5):994-1004.
2012: Rebekah M Brennan; Jacqueline M Burrows; Rajiv Khanna; James McCluskey; John J Miles; Michelle A Neller; Jan Petersen; Jamie Rossjohn; Corey Smith; Scott R Burrows
The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2742-8.
2012: C Smith; J J Miles; Rajiv Khanna
Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(1):15-26.
2011: Corey Smith; Michelle Martinez; Jesse Peet; Rajiv Khanna
Differential outcome of IL-2/anti-IL-2 complex therapy on effector and memory CD8+ T cells following vaccination with an adenoviral vector encoding EBV epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5784-90.
2011: Vijayendra Dasari; Corey Smith; Jie Zhong; Gillian Scott; William Rawlinson; Rajiv Khanna
Recombinant glycoprotein B vaccine formulation with Toll-like receptor 9 agonist and immune-stimulating complex induces specific immunity against multiple strains of cytomegalovirus.
The Journal of general virology 2011;92(Pt 5):1021-31.
2011: Rajiv Khanna; Scott R Burrows
Human immunology: a case for the ascent of non-furry immunology.
Immunology and cell biology 2011;89(3):330-1.
2011: Scott R Burrows; Denis Moss; Rajiv Khanna
Understanding human T-cell-mediated immunoregulation through herpesviruses.
Immunology and cell biology 2011;89(3):352-8.
2010: Corey Smith; Rajiv Khanna
Herpesvirus vaccines: challenges and future prospects.
Human vaccines 2010;6(12):1062-7.
2010: Jie Zhong; Rajiv Khanna
Delineating the role of CD4+ T cells in the activation of human cytomegalovirus-specific immune responses following immunization with Ad-gBCMVpoly vaccine: implications for vaccination of immunocompromised individuals.
The Journal of general virology 2010;91(Pt 12):2994-3001.
2010: Siok-Keen Tey; Felicia Goodrum; Rajiv Khanna
CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138.
The Journal of general virology 2010;91(Pt 8):2040-8.
2010: Stephanie Gras; Zhenjun Chen; John J Miles; Yu Chih Liu; Melissa J Bell; Lucy C Sullivan; Lars Kjer-Nielsen; Rebekah M Brennan; Jacqueline M Burrows; Michelle A Neller; Rajiv Khanna; Anthony W Purcell; Andrew G Brooks; James McCluskey; Jamie Rossjohn; Scott R Burrows
Allelic polymorphism in the T cell receptor and its impact on immune responses.
The Journal of experimental medicine 2010;207(7):1555-67.
2010: Scott R Burrows; Zhenjun Chen; Julia K Archbold; Fleur E Tynan; Travis Beddoe; Lars Kjer-Nielsen; John J Miles; Rajiv Khanna; Denis Moss; Yu Chih Liu; Stephanie Gras; Lyudmila Kostenko; Rebekah M Brennan; Craig S Clements; Andrew G Brooks; Anthony W Purcell; James McCluskey; Jamie Rossjohn
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10608-13.
2010: Katherine K Wynn; Tania Crough; Scott Campbell; Keith McNeil; Andrew Galbraith; Denis Moss; Sharon L Silins; Scott Bell; Rajiv Khanna
Narrowing of T-cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients.
Immunology and cell biology 2010;88(2):125-35.
2010: Corey Smith; Rajiv Khanna
Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies.
Methods in molecular biology (Clifton, N.J.) 2010;651():49-59.
2010: Geoffrey R Hill; S-K Tey; L Beagley; Tania Crough; J A Morton; Andrew D Clouston; P Whiting; Rajiv Khanna
Successful immunotherapy of HCMV disease using virus-specific T cells expanded from an allogeneic stem cell transplant recipient.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(1):173-9.
2009: Jie Zhong; Rajiv Khanna
Ad-gBCMVpoly: A novel chimeric vaccine strategy for human cytomegalovirus-associated diseases.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2009;46 Suppl 4():S68-72.
2009: Michael Rist; Corey Smith; Melissa J Bell; Scott R Burrows; Rajiv Khanna
Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition.
Blood 2009;114(11):2244-53.
2009: Corey Smith; Naohiro Wakisaka; Tania Crough; Jesse Peet; Tomokazu Yoshizaki; Leone Beagley; Rajiv Khanna
Discerning regulation of cis- and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self-aggregation.
Blood 2009;113(24):6148-52.
2009: Corey Smith; Leone Beagley; Rajiv Khanna
Acquisition of polyfunctionality by Epstein-Barr virus-specific CD8+ T cells correlates with increased resistance to galectin-1-mediated suppression.
Journal of virology 2009;83(12):6192-8.
2009: Melissa J Bell; Jacqueline M Burrows; Rebekah Brennan; John J Miles; Ross Tellam; James McCluskey; Jamie Rossjohn; Rajiv Khanna; Scott R Burrows
The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length.
Molecular immunology 2009;46(8-9):1911-7.
2009: Tania Crough; Rajiv Khanna
Immunobiology of human cytomegalovirus: from bench to bedside.
Clinical microbiology reviews 2009;22(1):76-98, Table of Contents.
2008: Corey Smith; Michelle Martinez; Leanne Cooper; Michael Rist; Jie Zhong; Rajiv Khanna
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals.
European journal of immunology 2008;38(7):1857-66.
2008: Katherine K Wynn; Zara Fulton; Leanne Cooper; Sharon L Silins; Stephanie Gras; Julia K Archbold; Fleur E Tynan; John J Miles; James McCluskey; Scott R Burrows; Jamie Rossjohn; Rajiv Khanna
Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.
Blood 2008;111(8):4283-92.
2008: Jacqueline M Burrows; Melissa J Bell; Rebekah Brennan; John J Miles; Rajiv Khanna; Scott R Burrows
Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition.
Molecular immunology 2008;45(6):1818-24.
2008: Jie Zhong; Michael Rist; Leanne Cooper; Corey Smith; Rajiv Khanna
Induction of pluripotent protective immunity following immunisation with a chimeric vaccine against human cytomegalovirus.
PloS one 2008;3(9):e3256.
2008: Natasha Webb; Geoff Connolly; Ross Tellam; Alpha S Yap; Rajiv Khanna
Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1.
PloS one 2008;3(9):e3254.
2007: Tania Crough; Chrysa Fazou; Julissa Weiss; Scott Campbell; Miles P Davenport; Scott C Bell; Andrew Galbraith; Keith McNeil; Rajiv Khanna
Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response.
Journal of virology 2007;81(20):11538-42.
2007: Maher K Gandhi; Guido Moll; Corey Smith; Ujjwal Dua; Eleanore Lambley; Olivier Ramuz; Devinder Gill; Paula Marlton; John F Seymour; Rajiv Khanna
Galectin-1 mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma.
Blood 2007;110(4):1326-9.
2007: Saparna Pai; Brendan O'Sullivan; Ibtissam Abdul-Jabbar; Judy Peng; Geoff Connoly; Rajiv Khanna; Ranjeny Thomas
Nasopharyngeal carcinoma-associated Epstein-Barr virus-encoded oncogene latent membrane protein 1 potentiates regulatory T-cell function.
Immunology and cell biology 2007;85(5):370-7.
2007: Susan Walker; Chrysa Fazou; Tania Crough; R Holdsworth; P Kiely; M Veale; S Bell; A Gailbraith; K McNeil; S Jones; Rajiv Khanna
Ex vivo monitoring of human cytomegalovirus-specific CD8+ T-cell responses using QuantiFERON-CMV.
Transplant infectious disease : an official journal of the Transplantation Society 2007;9(2):165-70.
2007: Jacqueline M Burrows; Katherine K Wynn; Fleur E Tynan; Julia K Archbold; John J Miles; Melissa J Bell; Rebekah M Brennan; Susan Walker; James McCluskey; Jamie Rossjohn; Rajiv Khanna; Scott R Burrows
The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV.
European journal of immunology 2007;37(4):946-53.
2007: Ross Tellam; Mark H Fogg; Michael Rist; Geoff Connolly; David Tscharke; Natasha Webb; Lea Heslop; Fred Wang; Rajiv Khanna
Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes.
The Journal of experimental medicine 2007;204(3):525-32.
2007: Ross Tellam; Michael Rist; Geoff Connolly; Natasha Webb; Chrysa Fazou; Fred Wang; Rajiv Khanna
Translation efficiency of EBNA1 encoded by lymphocryptoviruses influences endogenous presentation of CD8+ T cell epitopes.
European journal of immunology 2007;37(2):328-37.
2007: Angela K Nehring; Ujjwal Dua; Peter Mollee; Devinder Gill; Karen Grimmett; Rajiv Khanna; Denis Moss; Maher K Gandhi
Epstein-Barr virus T-cell immunity despite rituximab.
British journal of haematology 2007;136(4):628-32.
2006: Corey Smith; Leanne Cooper; Melinda Burgess; Michael Rist; Natasha Webb; Eleanore Lambley; Ross Tellam; Paula Marlton; John F Seymour; Maher Gandhi; Rajiv Khanna
Functional reversion of antigen-specific CD8+ T cells from patients with Hodgkin lymphoma following in vitro stimulation with recombinant polyepitope.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4897-906.
2006: Maher K Gandhi; Eleanore Lambley; Jaikumar Duraiswamy; Ujjwal Dua; Corey Smith; Suzanne Elliott; Devinder Gill; Paula Marlton; John Seymour; Rajiv Khanna
Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients.
Blood 2006;108(7):2280-9.
2006: Maher Gandhi; Rajiv Khanna
Epstein-Barr virus and advanced chronic lymphocytic leukemia: innocent until proven guilty?
Leukemia & lymphoma 2006;47(5):779-80.
2006: Barbara Cameron; Mandvi Bharadwaj; Jacqueline M Burrows; Chrysa Fazou; Denis Wakefield; Ian Hickie; Rosemary A Ffrench; Rajiv Khanna; Andrew Lloyd
Prolonged illness after infectious mononucleosis is associated with altered immunity but not with increased viral load.
The Journal of infectious diseases 2006;193(5):664-71.
2006: Maher K Gandhi; Eleanore Lambley; Jacqueline M Burrows; Ujjwal Dua; Suzanne Elliott; Peter Shaw; H Miles Prince; Max Wolf; Kerrie Clarke; Craig Underhill; Tony Mills; Peter Mollee; Devinder Gill; Paula Marlton; John F Seymour; Rajiv Khanna
Plasma Epstein-Barr virus (EBV) DNA is a biomarker for EBV-positive Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):460-4.
2005: Maher K Gandhi; Rajiv Khanna
Viruses and lymphoma.
Pathology 2005;37(6):420-33.
2005: Rajiv Khanna; Denis Moss; Maher Gandhi
Technology insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies.
Nature clinical practice. Oncology 2005;2(3):138-49.
2005: Michael Rist; Leanne Cooper; Rebecca Elkington; Susan Walker; Chrysa Fazou; Ross Tellam; Tania Crough; Rajiv Khanna
Ex vivo expansion of human cytomegalovirus-specific cytotoxic T cells by recombinant polyepitope: implications for HCMV immunotherapy.
European journal of immunology 2005;35(3):996-1007.
2005: Rebecca Elkington; Rajiv Khanna
Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: implications for graft-versus-host disease.
Blood 2005;105(3):1362-4.
2005: Tania Crough; Jacqueline M Burrows; Chrysa Fazou; Susan Walker; Miles P Davenport; Rajiv Khanna
Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.
European journal of immunology 2005;35(1):139-49.
2004: Maher K Gandhi; Rajiv Khanna
Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments.
The Lancet infectious diseases 2004;4(12):725-38.
2004: Rebecca Elkington; Naglaa H Shoukry; Susan Walker; Tania Crough; Chrysa Fazou; Amitinder Kaur; Christopher M Walker; Rajiv Khanna
Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H.
European journal of immunology 2004;34(11):3216-26.
2004: Jacqueline M Burrows; Lindell Bromham; Megan Woolfit; Gwenaël Piganeau; Ross Tellam; Geoff Connolly; Natasha Webb; Leith Poulsen; Leanne Cooper; Scott R Burrows; Denis Moss; Sofia M Haryana; Mun Ng; John M Nicholls; Rajiv Khanna
Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia.
Journal of virology 2004;78(13):7131-7.
2004: Joanne E Davis; Martina A Sherritt; Mandvi Bharadwaj; Leanne E Morrison; Suzanne L Elliott; Laurie M Kear; Joanne Maddicks-Law; Tom Kotsimbos; Devinder Gill; Monique Malouf; Michael C Falk; Rajiv Khanna; Denis Moss
Determining virological, serological and immunological parameters of EBV infection in the development of PTLD.
International immunology 2004;16(7):983-9.
2004: Ross Tellam; Geoff Connolly; Katherine J Green; John J Miles; Denis Moss; Scott R Burrows; Rajiv Khanna
Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1.
The Journal of experimental medicine 2004;199(10):1421-31.
2004: Maher K Gandhi; Ross Tellam; Rajiv Khanna
Epstein-Barr virus-associated Hodgkin's lymphoma.
British journal of haematology 2004;125(3):267-81.
2004: Jaikumar Duraiswamy; Mandvi Bharadwaj; Ross Tellam; Geoff Connolly; Leanne Cooper; Denis Moss; Scott Thomson; Patricia Yotnda; Rajiv Khanna
Induction of therapeutic T-cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccine.
Cancer research 2004;64(4):1483-9.
2003: Ross Tellam; Geoff Connolly; Natasha Webb; Jaikumar Duraiswamy; Rajiv Khanna
Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity.
Blood 2003;102(13):4535-40.
2003: Scott R Burrows; Rebecca Elkington; John J Miles; Katherine J Green; Susan Walker; Sofia M Haryana; Denis Moss; Heather Dunckley; Jacqueline M Burrows; Rajiv Khanna
Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1407-12.
2003: Jaikumar Duraiswamy; Jacqueline M Burrows; Mandvi Bharadwaj; Scott R Burrows; Leanne Cooper; Nattiya Pimtanothai; Rajiv Khanna
Ex vivo analysis of T-cell responses to Epstein-Barr virus-encoded oncogene latent membrane protein 1 reveals highly conserved epitope sequences in virus isolates from diverse geographic regions.
Journal of virology 2003;77(13):7401-10.
2003: Martina A Sherritt; Mandvi Bharadwaj; Jacqueline M Burrows; Leanne E Morrison; Suzanne L Elliott; Joanne E Davis; Laurie M Kear; Richard E Slaughter; Scott C Bell; Andrew J Galbraith; Rajiv Khanna; Denis Moss
Reconstitution of the latent T-lymphocyte response to Epstein-Barr virus is coincident with long-term recovery from posttransplant lymphoma after adoptive immunotherapy.
Transplantation 2003;75(9):1556-60.
2003: Rebecca Elkington; Susan Walker; Tania Crough; Moira Menzies; Ross Tellam; Mandvi Bharadwaj; Rajiv Khanna
Ex vivo profiling of CD8+-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers.
Journal of virology 2003;77(9):5226-40.
2003: Jaikumar Duraiswamy; Martina A Sherritt; Scott Thomson; Ross Tellam; Leanne Cooper; Geoff Connolly; Mandvi Bharadwaj; Rajiv Khanna
Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma.
Blood 2003;101(8):3150-6.
2002: Saparna Pai; Brendan O'Sullivan; Leanne Cooper; Ranjeny Thomas; Rajiv Khanna
RelB nuclear translocation mediated by C-terminal activator regions of Epstein-Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells.
Journal of virology 2002;76(4):1914-21.
2001: Sharon L Silins; Martina A Sherritt; J M Silleri; SM Cross; Suzanne L Elliott; Mandvi Bharadwaj; T T Le; Leanne E Morrison; Rajiv Khanna; Denis Moss; A Suhrbier; Ihor Misko
Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load.
Blood 2001;98(13):3739-44.
2001: Saparna Pai; Rajiv Khanna
Role of LMP1 in immune control of EBV infection.
Seminars in cancer biology 2001;11(6):455-60.
2001: Mandvi Bharadwaj; Scott R Burrows; Jacqueline M Burrows; Denis Moss; M Catalina; Rajiv Khanna
Longitudinal dynamics of antigen-specific CD8+ cytotoxic T lymphocytes following primary Epstein-Barr virus infection.
Blood 2001;98(8):2588-9.
2001: Ross Tellam; Martina A Sherritt; Scott Thomson; Ross Tellam; Denis Moss; Scott R Burrows; E Wiertz; Rajiv Khanna
Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+ T cell recognition.
The Journal of biological chemistry 2001;276(36):33353-60.
2001: Mandvi Bharadwaj; Martina A Sherritt; Rajiv Khanna; Denis Moss
Contrasting Epstein-Barr virus-specific cytotoxic T cell responses to HLA A2-restricted epitopes in humans and HLA transgenic mice: implications for vaccine design.
Vaccine 2001;19(27):3769-77.
2001: Rajiv Khanna; Ross Tellam; Jaikumar Duraiswamy; Leanne Cooper
Immunotherapeutic strategies for EBV-associated malignancies.
Trends in molecular medicine 2001;7(6):270-6.
2001: Denis Moss; Scott R Burrows; Sharon L Silins; Ihor Misko; Rajiv Khanna
The immunology of Epstein-Barr virus infection.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1408):475-88.
2001: Martina A Sherritt; Leanne Cooper; Denis Moss; Norbert Kienzle; John D Altman; Rajiv Khanna
Immunization with tumor-associated epitopes fused to an endoplasmic reticulum translocation signal sequence affords protection against tumors with down-regulated expression of MHC and peptide transporters.
International immunology 2001;13(3):265-71.
2000: Norbert Kienzle; Marion Buck; Sharon L Silins; Scott R Burrows; Denis Moss; A Winterhalter; A Brooks; Rajiv Khanna
Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1840-6.
2000: Rajiv Khanna; Scott R Burrows
Role of cytotoxic T lymphocytes in Epstein-Barr virus-associated diseases.
Annual review of microbiology 2000;54():19-48.
1999: Rajiv Khanna; S Bell; Martina A Sherritt; Andrew J Galbraith; Scott R Burrows; L Rafter; Belinda Clarke; R Slaughter; Michael C Falk; J Douglass; T Williams; Suzanne L Elliott; Denis Moss
Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10391-6.
1999: Rajiv Khanna; Denis Moss; Scott R Burrows
Vaccine strategies against Epstein-Barr virus-associated diseases: lessons from studies on cytotoxic T-cell-mediated immune regulation.
Immunological reviews 1999;170():49-64.
1999: Denis Moss; Rajiv Khanna; Martina A Sherritt; Suzanne L Elliott; Scott R Burrows
Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies.
Journal of acquired immune deficiency syndromes (1999) 1999;21 Suppl 1():S80-3.
1999: Norbert Kienzle; Tom Sculley; S Greco; Rajiv Khanna
Cutting edge: silencing virus-specific cytotoxic T cell-mediated immune recognition by differential splicing: a novel implication of RNA processing for antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6963-6.
1999: Rajiv Khanna; Sharon L Silins; Z Weng; D Gatchell; Scott R Burrows; Leanne Cooper
Cytotoxic T cell recognition of allelic variants of HLA B35 bound to an Epstein-Barr virus epitope: influence of peptide conformation and TCR-peptide interaction.
European journal of immunology 1999;29(5):1587-97.
1999: Scott R Burrows; Rajiv Khanna; Sharon L Silins; Denis Moss
The influence of antiviral T-cell responses on the alloreactive repertoire.
Immunology today 1999;20(5):203-7.
1999: Ihor Misko; SM Cross; Rajiv Khanna; Suzanne L Elliott; C Schmidt; SJ Pye; Sharon L Silins
Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2279-84.
1999: Rajiv Khanna; Martina A Sherritt; Scott R Burrows
EBV structural antigens, gp350 and gp85, as targets for ex vivo virus-specific CTL during acute infectious mononucleosis: potential use of gp350/gp85 CTL epitopes for vaccine design.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):3063-9.
1999: Scott R Burrows; Rajiv Khanna; Denis Moss
Direct alloreactivity by human cytotoxic T lymphocytes can Be inhibited by altered peptide ligand antagonism.
Blood 1999;93(3):1020-4.
1998: Norbert Kienzle; Tom Sculley; L Poulsen; Marion Buck; S Cross; Nancy Raab-Traub; Rajiv Khanna
Identification of a cytotoxic T-lymphocyte response to the novel BARF0 protein of Epstein-Barr virus: a critical role for antigen expression.
Journal of virology 1998;72(8):6614-20.
1998: Scott A Thomson; Scott R Burrows; Ihor Misko; Denis Moss; Barbara E H Coupar; Rajiv Khanna
Targeting a polyepitope protein incorporating multiple class II-restricted viral epitopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: a novel approach to vaccine design.
Journal of virology 1998;72(3):2246-52.
1998: C A White; Scott A Thomson; L Cooper; Peter van Endert; R Tampe; Barbara E H Coupar; L Qiu; P G Parsons; Denis Moss; Rajiv Khanna
Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.
International journal of cancer. Journal international du cancer 1998;75(4):590-5.
1998: Rajiv Khanna
Tumour surveillance: missing peptides and MHC molecules.
Immunology and cell biology 1998;76(1):20-6.
1998: Rajiv Khanna; Scott R Burrows; J Nicholls; L M Poulsen
Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes.
European journal of immunology 1998;28(2):451-8.
1998: Rajiv Khanna; Pierre Busson; S R Burrows; C Raffoux; Denis Moss; J M Nicholls; Leanne Cooper
Molecular characterization of antigen-processing function in nasopharyngeal carcinoma (NPC): evidence for efficient presentation of Epstein-Barr virus cytotoxic T-cell epitopes by NPC cells.
Cancer research 1998;58(2):310-4.
1997: Rajiv Khanna; Leanne Cooper; Norbert Kienzle; Denis Moss; Scott R Burrows; K K Khanna
Engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5782-5.
1997: Rajiv Khanna; R W Slade; L Poulsen; Denis Moss; Scott R Burrows; J Nicholls; Jacqueline M Burrows
Evolutionary dynamics of genetic variation in Epstein-Barr virus isolates of diverse geographical origins: evidence for immune pressure-independent genetic drift.
Journal of virology 1997;71(11):8340-6.
1997: Rajiv Khanna; Scott R Burrows; PM Steigerwald-Mullen; Denis Moss; Michael Kurilla; L Cooper
Targeting Epstein-Barr virus nuclear antigen 1 (EBNA1) through the class II pathway restores immune recognition by EBNA1-specific cytotoxic T lymphocytes: evidence for HLA-DM-independent processing.
International immunology 1997;9(10):1537-43.
1997: Rajiv Khanna; Scott R Burrows; A Neisig; J Neefjes; Denis Moss; Sharon L Silins
Hierarchy of Epstein-Barr virus-specific cytotoxic T-cell responses in individuals carrying different subtypes of an HLA allele: implications for epitope-based antiviral vaccines.
Journal of virology 1997;71(10):7429-35.
1997: Scott R Burrows; Sharon L Silins; Rajiv Khanna; Jacqueline M Burrows; M Rischmueller; James McCluskey; Denis Moss
Cross-reactive memory T cells for Epstein-Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex-bound peptide by T cells and its role in alloreactivity.
European journal of immunology 1997;27(7):1726-36.
1997: Rajiv Khanna; Scott R Burrows; Scott A Thomson; Denis Moss; P Cresswell; L M Poulsen; L Cooper
Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3619-25.
1997: Joy Gardner; Rajiv Khanna; Martina A Sherritt; Andreas Suhrbier
Use of recombinant vaccinia to restimulate antigen specific human peripheral blood cytotoxic T lymphocytes.
Journal of virological methods 1997;65(1):105-9.
1997: Rajiv Khanna; Scott R Burrows; J M Burrows
The role of cytotoxic T lymphocytes in the evolution of genetically stable viruses.
Trends in microbiology 1997;5(2):64-9.
1996: Rajiv Khanna; Scott R Burrows; Sharon L Silins; Denis Moss; L M Poulsen; Jacqueline M Burrows
Cytotoxic T-lymphocyte clones specific for an immunodominant epitope display discerning antagonistic response to naturally occurring Epstein-Barr virus variants.
Journal of virology 1996;70(10):7306-11.
1996: Rajiv Khanna; Scott R Burrows; Denis Moss; Sharon L Silins
Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: implications for cytotoxic T-lymphocyte control of EBV-associated malignancies.
Journal of virology 1996;70(8):5357-62.
1996: Jacqueline M Burrows; Rajiv Khanna; Tom Sculley; M P Alpers; Denis Moss; Scott R Burrows
Identification of a naturally occurring recombinant Epstein-Barr virus isolate from New Guinea that encodes both type 1 and type 2 nuclear antigen sequences.
Journal of virology 1996;70(7):4829-33.
1996: C A White; SM Cross; Michael Kurilla; B M Kerr; C Schmidt; Ihor Misko; Rajiv Khanna; Denis Moss
Recruitment during infectious mononucleosis of CD3+CD4+CD8+ virus-specific cytotoxic T cells which recognise Epstein-Barr virus lytic antigen BHRF1.
Virology 1996;219(2):489-92.
1996: Jacqueline M Burrows; Scott R Burrows; L M Poulsen; Tom Sculley; Denis Moss; Rajiv Khanna
Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: implications for virus evolution.
Journal of virology 1996;70(4):2490-6.
1995: Rajiv Khanna; Scott R Burrows; P M Steigerwald-Mullen; Scott A Thomson; Michael Kurilla; Denis Moss
Isolation of cytotoxic T lymphocytes from healthy seropositive individuals specific for peptide epitopes from Epstein-Barr virus nuclear antigen 1: implications for viral persistence and tumor surveillance.
Virology 1995;214(2):633-7.
1995: Scott R Burrows; Sharon L Silins; Denis Moss; Rajiv Khanna; Ihor Misko; V P Argaet
T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen.
The Journal of experimental medicine 1995;182(6):1703-15.
1995: Rajiv Khanna; Scott R Burrows; Denis Moss
Immune regulation in Epstein-Barr virus-associated diseases.
Microbiological reviews 1995;59(3):387-405.
1995: Scott A Thomson; Rajiv Khanna; Joy Gardner; Scott R Burrows; Barbara E H Coupar; Denis Moss; Andreas Suhrbier
Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5845-9.
1995: Martin Rowe; Rajiv Khanna; C A Jacob; V Argaet; A Kelly; S Powis; M Belich; D Croom-Carter; S Lee; Scott R Burrows
Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression.
European journal of immunology 1995;25(5):1374-84.
1995: Steven P Lee; S Morgan; J Skinner; Wendy A Thomas; S R Jones; J Sutton; Rajiv Khanna; H C Whittle; Alan B Rickinson
Epstein-Barr virus isolates with the major HLA B35.01-restricted cytotoxic T lymphocyte epitope are prevalent in a highly B35.01-positive African population.
European journal of immunology 1995;25(1):102-10.
1994: Scott R Burrows; J Gardner; Rajiv Khanna; Trina Stewart; Denis Moss; S Rodda; Andreas Suhrbier
Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3.
The Journal of general virology 1994;75 ( Pt 9)():2489-93.
1994: Rajiv Khanna; Scott R Burrows; V Argaet; Denis Moss
Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumour cell line.
International immunology 1994;6(4):639-45.
1994: Scott R Burrows; Rajiv Khanna; Jacqueline M Burrows; Denis Moss
An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.
The Journal of experimental medicine 1994;179(4):1155-61.
1994: Denis Moss; Scott R Burrows; Andreas Suhrbier; Rajiv Khanna
Potential antigenic targets on Epstein-Barr virus-associated tumours and the host response.
Ciba Foundation symposium 1994;187():4-13; discussion 13-20.
1993: Rajiv Khanna; C A Jacob; Scott R Burrows; Denis Moss
Presentation of endogenous viral peptide epitopes by anti-CD40 stimulated human B cells following recombinant vaccinia infection.
Journal of immunological methods 1993;164(1):41-9.
1993: Rajiv Khanna; Scott R Burrows; Andreas Suhrbier; C A Jacob; H Griffin; Ihor Misko; Tom Sculley; Martin Rowe; A B Rickinson; Denis Moss
EBV peptide epitope sensitization restores human cytotoxic T cell recognition of Burkitt's lymphoma cells. Evidence for a critical role for ICAM-2.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5154-62.
1992: Rajiv Khanna; Scott R Burrows; Michael Kurilla; C A Jacob; Ihor Misko; Tom Sculley; Elliott Kieff; Denis Moss
Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development.
The Journal of experimental medicine 1992;176(1):169-76.
1992: Scott R Burrows; Andreas Suhrbier; Rajiv Khanna; Denis Moss
Rapid visual assay of cytotoxic T-cell specificity utilizing synthetic peptide induced T-cell-T-cell killing.
Immunology 1992;76(1):174-5.
1992: Denis Moss; Scott R Burrows; Rajiv Khanna; Ihor Misko; Tom Sculley
Immune surveillance against Epstein-Barr virus.
Seminars in immunology 1992;4(2):97-104.
1991: Rajiv Khanna; C A Jacob; Scott R Burrows; Michael Kurilla; Elliott Kieff; Ihor Misko; Tom Sculley; Denis Moss
Expression of Epstein-Barr virus nuclear antigens in anti-IgM-stimulated B cells following recombinant vaccinia infection and their recognition by human cytotoxic T cells.
Immunology 1991;74(3):504-10.
1991: Denis Moss; Ihor Misko; Tom Sculley; A Apolloni; Rajiv Khanna; Scott R Burrows
Immune regulation of Epstein-Barr virus (EBV): EBV nuclear antigen as a target for EBV-specific T cell lysis.
Springer seminars in immunopathology 1991;13(2):147-56.