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Kusum Kharbanda

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Liver Diseases, Alcoholic

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Publications

TOP 3
Valentina Medici; Noreene M Shibata; Natalie J Török; Rima Woods; Peter J Havel; Joy X Jiang; Kusum K Kharbanda; Kyoungmi Kim; Janine M LaSalle; Sarah Liu; Bo Lonnerdal; Sridevi Devaraj; Jesse A Engelberg; Charles H Halsted
Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.
Kusum K Kharbanda
Methionine metabolic pathway in alcoholic liver injury.
Kusum K Kharbanda; Patricia E Molina; Fawzia Bardag-Gorce; Shirish Barve; Natalia A Osna
Impact of altered methylation in cytokine signaling and proteasome function in alcohol and viral-mediated diseases.

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2013: Valentina Medici; Noreene M Shibata; Natalie J Török; Rima Woods; Peter J Havel; Joy X Jiang; Kusum K Kharbanda; Kyoungmi Kim; Janine M LaSalle; Sarah Liu; Bo Lonnerdal; Sridevi Devaraj; Jesse A Engelberg; Charles H Halsted
Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.
Hepatology (Baltimore, Md.) 2013;57(2):555-65.
2013: Kusum K Kharbanda
Methionine metabolic pathway in alcoholic liver injury.
Current opinion in clinical nutrition and metabolic care 2013;16(1):89-95.
2013: Kusum K Kharbanda; Patricia E Molina; Fawzia Bardag-Gorce; Shirish Barve; Natalia A Osna
Impact of altered methylation in cytokine signaling and proteasome function in alcohol and viral-mediated diseases.
Alcoholism, clinical and experimental research 2013;37(1):1-7.
2012: Natalia A Osna; Steven A Weinman; Ronda L White; Fawzia Bardag-Gorce; Terrence M Donohue; Kusum K Kharbanda
Ethanol and hepatitis C virus suppress peptide-MHC class I presentation in hepatocytes by altering proteasome function.
Alcoholism, clinical and experimental research 2012;36(12):2028-35.
2011: Michael L McCaskill; Kusum K Kharbanda; Dean J Tuma; Jill D Reynolds; Jane Devasure; Joseph H Sisson; Todd A Wyatt
Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke.
Alcoholism, clinical and experimental research 2011;35(6):1106-13.
2011: Razia S Aziz-Seible; Serene M Lee; Kusum K Kharbanda; Benita L McVicker; Carol A Casey
Ethanol feeding potentiates the pro-inflammatory response of Kupffer cells to cellular fibronectin.
Alcoholism, clinical and experimental research 2011;35(4):717-25.
2011: Razia S Aziz-Seible; Benita L McVicker; Kusum K Kharbanda; Carol A Casey
Cellular fibronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury.
World journal of hepatology 2011;3(2):45-55.
2011: Mostafa I Waly; Kusum K Kharbanda; Richard C Deth
Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner.
Alcoholism, clinical and experimental research 2011;35(2):277-83.
2010: Natalia A Osna; Ronda L White; Terrence M Donohue; Michael R Beard; Dean J Tuma; Kusum K Kharbanda
Impaired methylation as a novel mechanism for proteasome suppression in liver cells.
Biochemical and biophysical research communications 2010;391(2):1291-6.
2009: Kusum K Kharbanda; Sandra L Todero; Brian W Ward; John J Cannella; Dean J Tuma
Betaine administration corrects ethanol-induced defective VLDL secretion.
Molecular and cellular biochemistry 2009;327(1-2):75-8.
2009: Benita L McVicker; Pamela L Tuma; Kusum K Kharbanda; Serene M L Lee; Dean J Tuma
Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells.
World journal of gastroenterology : WJG 2009;15(21):2609-16.
2009: Kusum K Kharbanda
Alcoholic liver disease and methionine metabolism.
Seminars in liver disease 2009;29(2):155-65.
2009: Diane S Allen-Gipson; Justin C Jarrell; Kristina L Bailey; James E Robinson; Kusum K Kharbanda; Joseph H Sisson; Todd A Wyatt
Ethanol blocks adenosine uptake via inhibiting the nucleoside transport system in bronchial epithelial cells.
Alcoholism, clinical and experimental research 2009;33(5):791-8.
2009: Kusum K Kharbanda; Vasanthy Vigneswara; Benita L McVicker; Anna U Newlaczyl; Kevin Bailey; Dean J Tuma; David E Ray; Wayne G Carter
Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats.
Biochemical and biophysical research communications 2009;381(4):523-7.
2009: Shana R Dalton; Serene M L Lee; Rachel N King; Amin A Nanji; Kusum K Kharbanda; Carol A Casey; Benita L McVicker
Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice.
Biochemical pharmacology 2009;77(7):1283-90.
2009: Peter Sykora; Kusum K Kharbanda; Sara E Crumm; Alan Cahill
S-adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats.
Alcoholism, clinical and experimental research 2009;33(1):1-9.
2007: Terrence M Donohue; Tiana V Curry-McCoy; Amin A Nanji; Kusum K Kharbanda; Natalia A Osna; Stanley J Radio; Sandra L Todero; Ronda L White; Carol A Casey
Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats.
Alcoholism, clinical and experimental research 2007;31(11):1944-52.
2007: Kusum K Kharbanda
Role of transmethylation reactions in alcoholic liver disease.
World journal of gastroenterology : WJG 2007;13(37):4947-54.
2007: Vishnudutt Purohit; Manal F Abdelmalek; Shirish Barve; Norlin J Benevenga; Charles H Halsted; Neil Kaplowitz; Kusum K Kharbanda; Qi-Ying Liu; Shelly C Lu; Craig J McClain; Christine Swanson; Samir Zakhari
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
The American journal of clinical nutrition 2007;86(1):14-24.
2007: Terrence M Donohue; Tiana V Curry-McCoy; Sandra L Todero; Ronda L White; Kusum K Kharbanda; Amin A Nanji; Natalia A Osna
L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury.
Alcoholism, clinical and experimental research 2007;31(6):1053-60.
2007: Kusum K Kharbanda; Mark E Mailliard; Cheryl R Baldwin; Michael F Sorrell; Dean J Tuma
Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity.
Journal of hepatology 2007;46(6):1119-25.
2007: Kusum K Kharbanda; Mark E Mailliard; Cheryl R Baldwin; Harriet C Beckenhauer; Michael F Sorrell; Dean J Tuma
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway.
Journal of hepatology 2007;46(2):314-21.
2007: Benita L McVicker; Dean J Tuma; Kusum K Kharbanda; Jacy L Kubik; Carol A Casey
Effect of chronic ethanol administration on the in vitro production of proinflammatory cytokines by rat Kupffer cells in the presence of apoptotic cells.
Alcoholism, clinical and experimental research 2007;31(1):122-9.
2006: Shannon M Bailey; Gloria Robinson; Anita Pinner; Laura Chamlee; Elena Ulasova; MELISSA POMPILIUS; Grier P Page; David C Chhieng; Nirag C Jhala; Aimee Landar; Kusum K Kharbanda; Scott W Ballinger; Victor Darley-Usmar
S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(5):G857-67.
2005: Kusum K Kharbanda; David D Rogers; Mark E Mailliard; Gerri L Siford; Anthony J Barak; Harriet C Beckenhauer; Michael F Sorrell; Dean J Tuma
Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine.
Biochemical pharmacology 2005;70(12):1883-90.
2005: Todd A Wyatt; Kusum K Kharbanda; Dean J Tuma; Joseph H Sisson; John R Spurzem
Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair.
Alcohol (Fayetteville, N.Y.) 2005;36(1):31-40.
2005: Kusum K Kharbanda; David D Rogers; Mark E Mailliard; Gerri L Siford; Anthony J Barak; Harriet C Beckenhauer; Michael F Sorrell; Dean J Tuma
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes.
The Journal of nutrition 2005;135(3):519-24.
2004: Terrence M Donohue; Kusum K Kharbanda; Carol A Casey; Amin A Nanji
Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease.
Alcoholism, clinical and experimental research 2004;28(8):1257-63.
2004: Kusum K Kharbanda; David D Rogers; Todd A Wyatt; Michael F Sorrell; Dean J Tuma
Transforming growth factor-beta induces contraction of activated hepatic stellate cells.
Journal of hepatology 2004;41(1):60-6.
2003: Anthony J Barak; Harriet C Beckenhauer; Mark E Mailliard; Kusum K Kharbanda; Dean J Tuma
Betaine lowers elevated s-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats.
The Journal of nutrition 2003;133(9):2845-8.
2003: Robert G Bennett; Kusum K Kharbanda; Dean J Tuma
Inhibition of markers of hepatic stellate cell activation by the hormone relaxin.
Biochemical pharmacology 2003;66(5):867-74.
2002: Philippe Mathurin; Shigang Xiong; Kusum K Kharbanda; Nary Veal; Takeo Miyahara; Kenta Motomura; Richard A Rippe; Max G Bachem; Hidekazu Tsukamoto
IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(6):G981-90.
2002: Thomas L Freeman; Kusum K Kharbanda; Dean J Tuma; Mark E Mailliard
Inhibition of hepatic stellate cell collagen synthesis by N-(methylamino)isobutyric acid.
Biochemical pharmacology 2002;63(4):697-706.
2002: Kusum K Kharbanda; Kris A Shubert; Todd A Wyatt; Michael F Sorrell; Dean J Tuma
Effect of malondialdehyde-acetaldehyde-protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells.
Biochemical pharmacology 2002;63(3):553-62.
2001: Todd A Wyatt; Kusum K Kharbanda; Dean J Tuma; Joseph H Sisson
Malondialdehyde-acetaldehyde-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells.
Alcohol (Fayetteville, N.Y.) 2001;25(3):159-66.
2001: Kusum K Kharbanda; Sandra L Todero; K A Shubert; Michael F Sorrell; Dean J Tuma
Malondialdehyde-acetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cells.
Alcohol (Fayetteville, N.Y.) 2001;25(2):123-8.
2001: Anthony J Barak; Harriet C Beckenhauer; Kusum K Kharbanda; Dean J Tuma
Chronic ethanol consumption increases homocysteine accumulation in hepatocytes.
Alcohol (Fayetteville, N.Y.) 2001;25(2):77-81.
1999: Dean J Tuma; T E Smith; Courtney S Schaffert; Kusum K Kharbanda; Michael F Sorrell
Ethanol feeding selectively impairs the spreading of rat perivenous hepatocytes on extracellular matrix substrates.
Alcoholism, clinical and experimental research 1999;23(10):1673-80.
1997: Kusum K Kharbanda; Daniel L McVicker; RK Zetterman; Richard G MacDonald; Terrence M Donohue
Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration.
Hepatology (Baltimore, Md.) 1997;26(4):929-34.