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Olga Khersonsky

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Olga Khersonsky; Gert Kiss; Daniela Röthlisberger; Shira Albeck; David Baker; Orly Dym; Kendall N Houk; Dan S Tawfik
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Olga Khersonsky; Sergey Malitsky; Ilana Rogachev; Dan S Tawfik
Role of chemistry versus substrate binding in recruiting promiscuous enzyme functions.
Olga Khersonsky; Daniela Röthlisberger; Andrew M Wollacott; Paul Murphy; Orly Dym; Shira Albeck; Gert Kiss; Kendall N Houk; David Baker; Dan S Tawfik
Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution.

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All Publications

2012: Olga Khersonsky; Gert Kiss; Daniela Röthlisberger; Shira Albeck; David Baker; Orly Dym; Kendall N Houk; Dan S Tawfik
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10358-63.
2011: Olga Khersonsky; Sergey Malitsky; Ilana Rogachev; Dan S Tawfik
Role of chemistry versus substrate binding in recruiting promiscuous enzyme functions.
Biochemistry 2011;50(13):2683-90.
2011: Olga Khersonsky; Daniela Röthlisberger; Andrew M Wollacott; Paul Murphy; Orly Dym; Shira Albeck; Gert Kiss; Kendall N Houk; David Baker; Dan S Tawfik
Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution.
Journal of molecular biology 2011;407(3):391-412.
2010: Olga Khersonsky; Daniela Röthlisberger; Orly Dym; Shira Albeck; Colin J Jackson; David Baker; Dan S Tawfik
Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series.
Journal of molecular biology 2010;396(4):1025-42.
2009: Olga Khersonsky; Mira Rosenblat; Lilly Toker; Shiri Yacobson; Adrian Hugenmatter; Israel Silman; Joel Sussman; Michael Aviram; Dan S Tawfik
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
Biochemistry 2009;48(28):6644-54.
2006: Olga Khersonsky; Cintia Roodveldt; Dan S Tawfik
Enzyme promiscuity: evolutionary and mechanistic aspects.
Current opinion in chemical biology 2006;10(5):498-508.
2006: Gil Amitai; Leonid Gaidukov; Rellie Adani; Shelly Yishay; Guy Yacov; Moshe Kushnir; Shai Teitlboim; Michal Lindenbaum; Peter Bel; Olga Khersonsky; Dan S Tawfik; Haim Meshulam
Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase.
The FEBS journal 2006;273(9):1906-19.
2006: Olga Khersonsky; Dan S Tawfik
The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases.
The Journal of biological chemistry 2006;281(11):7649-56.
2006: Mira Rosenblat; Leonid Gaidukov; Olga Khersonsky; Jacob Vaya; Roni Oren; Dan S Tawfik; Michael Aviram
The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux.
The Journal of biological chemistry 2006;281(11):7657-65.
2006: Olga Khersonsky; Dan S Tawfik
Chromogenic and fluorogenic assays for the lactonase activity of serum paraoxonases.
Chembiochem : a European journal of chemical biology 2006;7(1):49-53.
2005: Olga Khersonsky; Dan S Tawfik
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase.
Biochemistry 2005;44(16):6371-82.
2005: Asaph Aharoni; Leonid Gaidukov; Olga Khersonsky; Stephen McQ Gould; Cintia Roodveldt; Dan S Tawfik
The 'evolvability' of promiscuous protein functions.
Nature genetics 2005;37(1):73-6.
2004: Michal Harel; Asaph Aharoni; Leonid Gaidukov; Boris Brumshtein; Olga Khersonsky; Ran Meged; Hay Dvir; Raimond B G Ravelli; Andrew McCarthy; Lilly Toker; Israel Silman; Joel Sussman; Dan S Tawfik
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.
Nature structural & molecular biology 2004;11(5):412-9.