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Rama Khokha

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Loredana Fiorentino; Loreto Gesualdo; Rama Khokha; Davide Lauro; Renato Lauro; Valentina Marchetti; Maria Mavilio; Rossella Menghini; Stefano Menini; Paola Pontrelli; Giuseppe Pugliese; Domenico Accili; Ivan Arisi; Viviana Casagrande; Michele Cavalera; Francesca Conserva; Mara D'Onofrio; Marta Fabrizi; Massimo Federici
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
Nina Jasmin Hewing; Rama Khokha; Steven Swendeman; Joost Vermaat; Gisela Weskamp; R V Paul Chan; Michael Chiang; Eric Farage; Krzysztof Glomski; Bela Anand-Apte; Carl P Blobel
Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Purna A Joshi; Marco A Di Grappa; Rama Khokha
Active allies: hormones, stem cells and the niche in adult mammopoiesis.

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2013: Loredana Fiorentino; Loreto Gesualdo; Rama Khokha; Davide Lauro; Renato Lauro; Valentina Marchetti; Maria Mavilio; Rossella Menghini; Stefano Menini; Paola Pontrelli; Giuseppe Pugliese; Domenico Accili; Ivan Arisi; Viviana Casagrande; Michele Cavalera; Francesca Conserva; Mara D'Onofrio; Marta Fabrizi; Massimo Federici
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
EMBO molecular medicine 2013;5(3):441-55.
2013: Nina Jasmin Hewing; Rama Khokha; Steven Swendeman; Joost Vermaat; Gisela Weskamp; R V Paul Chan; Michael Chiang; Eric Farage; Krzysztof Glomski; Bela Anand-Apte; Carl P Blobel
Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Investigative ophthalmology & visual science 2013;54(1):864-70.
2012: Purna A Joshi; Marco A Di Grappa; Rama Khokha
Active allies: hormones, stem cells and the niche in adult mammopoiesis.
Trends in endocrinology and metabolism: TEM 2012;23(6):299-309.
2012: Aditya Murthy; Yang Washington Shao; David S Smookler; Christopher Wedeles; Virginie Defamie; Rama Khokha
Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2876-83.
2012: Alexander G Beristain; Marco A Di Grappa; Swami R Narala; Rama Khokha
Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells.
Journal of cell science 2012;125(Pt 4):943-55.
2012: Aditya Murthy; Swami R Narala; Yang Washington Shao; Juan Carlos Zúñiga-Pflücker; Sam D Molyneux; Rama Khokha
Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis.
Immunity 2012;36(1):105-19.
2012: David R McIlwain; Aditya Murthy; Pamela S Ohashi; Kazuhito Ohishi; Andrew Wakeham; Haifeng C Xu; Sathish Kumar Maney; Thorsten Maretzky; Thorsten Berger; Carl P Blobel; Gordon Duncan; Koichi Hamada; Dieter Häussinger; Annick Itie-Youten; Rama Khokha; Karl S Lang; Philipp A Lang; Tak W Mak
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
Science (New York, N.Y.) 2012;335(6065):229-32.
2012: Purna A Joshi; Rama Khokha
The mammary stem cell conundrum: is it unipotent or multipotent?
Breast cancer research : BCR 2012;14(2):305.
2011: Quteba Ebrahem; Rama Khokha; Jian Hua Qi; Jonathan E Sears; Masahiko Sugimoto; Amit Vasanji; Mariya Ali; Alecia Cutler; Bela Anand-Apte
Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3.
Investigative ophthalmology & visual science 2011;52(9):6117-23.
2011: Rama Khokha; Zena Werb
Mammary gland reprogramming: metalloproteinases couple form with function.
Cold Spring Harbor perspectives in biology 2011;3(4):.
2011: Carlo V Hojilla; Hartland W Jackson; Rama Khokha
TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.
PloS one 2011;6(10):e26718.
2010: Hideaki Nakajima; Miyuki Ito; David S Smookler; Fumi Shibata; Yumi Fukuchi; Yoshihiro Morikawa; Yuichi Ikeda; Fumio Arai; Toshio Suda; Rama Khokha; Toshio Kitamura
TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.
Blood 2010;116(22):4474-82.
2010: Sylvain M Le Gall; Thorsten Maretzky; Priya D A Issuree; Xiao-Da Niu; Karina Reiss; Paul Saftig; Rama Khokha; Daniel Lundell; Carl P Blobel
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.
Journal of cell science 2010;123(Pt 22):3913-22.
2010: Daniel Schramek; Andreas Leibbrandt; Verena Sigl; Lukas Kenner; J Andrew Pospisilik; Heather J Lee; Reiko Hanada; Purna A Joshi; Antonios Aliprantis; Laurie Glimcher; Manolis Pasparakis; Rama Khokha; Christopher J Ormandy; Martin Widschwendter; Georg Schett; Josef M Penninger
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Nature 2010;468(7320):98-102.
2010: Sam D Molyneux; Marco A Di Grappa; Alexander G Beristain; Trevor McKee; Daniel H Wai; Jana Paderova; Meenakshi Kashyap; Pingzhao Hu; Tamara Maiuri; Swami R Narala; Vuk Stambolic; Jeremy Squire; Josef Penninger; Otto Sanchez; Timothy Triche; Geoffrey A Wood; Lawrence S Kirschner; Rama Khokha
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
The Journal of clinical investigation 2010;120(9):3310-25.
2010: Ilpo Koskivirta; Zamaneh Kassiri; Otto Rahkonen; Riku Kiviranta; Gavin Y Oudit; Trevor McKee; Ville Kytö; Antti Saraste; Eero Jokinen; Peter P Liu; Eero Vuorio; Rama Khokha
Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
The Journal of biological chemistry 2010;285(32):24487-93.
2010: Aditya Murthy; Virginie Defamie; David S Smookler; Marco A Di Grappa; Keisuke Horiuchi; Massimo Federici; Maria Sibilia; Carl P Blobel; Rama Khokha
Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice.
The Journal of clinical investigation 2010;120(8):2731-44.
2010: Purna A Joshi; Hartland W Jackson; Alexander G Beristain; Marco A Di Grappa; Patricia A Mote; Christine L Clarke; John Stingl; Paul D Waterhouse; Rama Khokha
Progesterone induces adult mammary stem cell expansion.
Nature 2010;465(7299):803-7.
2010: Sean E Gill; Isham Huizar; Eli M Bench; Samuel W Sussman; Ying Wang; Rama Khokha; William C Parks
Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
The American journal of pathology 2010;176(1):64-73.
2010: Loredana Fiorentino; Alessia Vivanti; Michele Cavalera; Valeria Marzano; Maurizio Ronci; Marta Fabrizi; Stefano Menini; Giuseppe Pugliese; Rossella Menghini; Rama Khokha; Renato Lauro; Andrea Urbani; Massimo Federici
Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.
Hepatology (Baltimore, Md.) 2010;51(1):103-10.
2010: Alison Aiken; Rama Khokha
Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice.
Biochimica et biophysica acta 2010;1803(1):121-32.
2009: Zamaneh Kassiri; Virginie Defamie; Mehrdad Hariri; Gavin Y Oudit; Shalini Anthwal; Fayez Dawood; Peter Liu; Rama Khokha
Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart.
The Journal of biological chemistry 2009;284(43):29893-904.
2009: Rossella Menghini; Stefano Menini; Roberta Amoruso; Loredana Fiorentino; Viviana Casagrande; Valeria Marzano; Federica Tornei; Pierfrancesco Bertucci; Carla Iacobini; Matteo Serino; Ottavia Porzio; Marta Letizia Hribal; Franco Folli; Rama Khokha; Andrea Urbani; Renato Lauro; Giuseppe Pugliese; Massimo Federici
Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.
Gastroenterology 2009;136(2):663-72.e4.
2008: Linda Troeberg; Kazunari Fushimi; Rama Khokha; Hervé EMONARD; Peter Ghosh; Hideaki Nagase
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3515-24.
2008: Gillian Murphy; Aditya Murthy; Rama Khokha
Clipping, shedding and RIPping keep immunity on cue.
Trends in immunology 2008;29(2):75-82.
2008: Anthony Fyles; Geoffrey Wood; Ming Li; Armen S Manoukian; Katrina Gowing; Rama Khokha; William Chapman; Ming Tsao
Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.
Gynecologic oncology 2008;108(2):395-401.
2008: William Cruz-Munoz; Rama Khokha
The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis.
Critical reviews in clinical laboratory sciences 2008;45(3):291-338.
2008: Carlo V Hojilla; Geoffrey A Wood; Rama Khokha
Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer.
Breast cancer research : BCR 2008;10(2):205.
2007: Gavin Y Oudit; Zamaneh Kassiri; Mikin P Patel; Mark Chappell; Jagdish Butany; Peter H Backx; Robert G Tsushima; James W Scholey; Rama Khokha; Josef M Penninger
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Cardiovascular research 2007;75(1):29-39.
2007: Geoffrey A Wood; Jimmie E Fata; Katrina L M Watson; Rama Khokha
Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus.
Reproduction (Cambridge, England) 2007;133(5):1035-44.
2007: Mei Sun; Manyin Chen; Fayez Dawood; Urszula Zurawska; Jeff Y Li; Thomas Parker; Zamaneh Kassiri; Lorrie A Kirshenbaum; Malcolm Arnold; Rama Khokha; Peter P Liu
Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state.
Circulation 2007;115(11):1398-407.
2007: Carlo V Hojilla; Ira Kim; Zamaneh Kassiri; Jimmie E Fata; Hui Fang; Rama Khokha
Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3.
Journal of cell science 2007;120(Pt 6):1050-60.
2007: R A Jones; C I Campbell; Edward J Gunther; Lewis A Chodosh; J J Petrik; Rama Khokha; Roger A Moorehead
Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation.
Oncogene 2007;26(11):1636-44.
2007: Solmaz Sahebjam; Rama Khokha; John S Mort
Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice.
Arthritis and rheumatism 2007;56(3):905-9.
2006: W Cruz-Munoz; Otto H Sanchez; M Di Grappa; Jane L English; Richard P Hill; Rama Khokha
Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice.
Oncogene 2006;25(49):6489-96.
2006: Gavin Y Oudit; Andrew Herzenberg; Zamaneh Kassiri; Denise Wong; Heather Reich; Rama Khokha; Michael A Crackower; Peter H Backx; Josef M Penninger; James W Scholey
Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis.
The American journal of pathology 2006;168(6):1808-20.
2006: Jane L English; Zamaneh Kassiri; Ilpo Koskivirta; Susan J Atkinson; Marco Di Grappa; Paul D Soloway; Hideaki Nagase; Eero Vuorio; Gillian Murphy; Rama Khokha
Individual Timp deficiencies differentially impact pro-MMP-2 activation.
The Journal of biological chemistry 2006;281(15):10337-46.
2006: D Holstead Jones; Tomoki Nakashima; Otto H Sanchez; Ivona Kozieradzki; Svetlana V Komarova; Ildiko Sarosi; Sean Morony; Evelyn Rubin; Renu Sarao; Carlo V Hojilla; Vukoslav Komnenovic; Young-Yun Kong; Martin Schreiber; S Jeffrey Dixon; Stephen M Sims; Rama Khokha; Teiji Wada; Josef M Penninger
Regulation of cancer cell migration and bone metastasis by RANKL.
Nature 2006;440(7084):692-6.
2006: David S Smookler; Fazilat F Mohammed; Zamaneh Kassiri; Gordon S Duncan; Tak W Mak; Rama Khokha
Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):721-5.
2005: Massimo Federici; Marta Letizia Hribal; Rossella Menghini; Hiroko Kanno; Valentina Marchetti; Ottavia Porzio; Susan W Sunnarborg; Stefano Rizza; Matteo Serino; Veronica Cunsolo; Davide Lauro; Alessandro Mauriello; David S Smookler; Paolo Sbraccia; Giorgio Sesti; David C Lee; Rama Khokha; Domenico Accili; Renato Lauro
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
The Journal of clinical investigation 2005;115(12):3494-505.
2005: Fazilat F Mohammed; Rama Khokha
Thinking outside the cell: proteases regulate hepatocyte division.
Trends in cell biology 2005;15(10):555-63.
2005: Anne Hakem; Otto Sanchez-Sweatman; Annick You-Ten; Gordon Duncan; Andrew Wakeham; Rama Khokha; Tak W Mak
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
Genes & development 2005;19(17):1974-9.
2005: Zamaneh Kassiri; Gavin Y Oudit; Otto H Sanchez; Fayez Dawood; Fazilat F Mohammed; Robert K Nuttall; Dylan R Edwards; Peter P Liu; Peter H Backx; Rama Khokha
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Circulation research 2005;97(4):380-90.
2005: Robert J R Singh; Justin C Mason; Elaine A Lidington; Dylan R Edwards; Robert K Nuttall; Rama Khokha; Vera Knauper; Gillian Murphy; Jelena Gavrilovic
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
Cardiovascular research 2005;67(1):39-49.
2005: Mandana Mahmoodi; Solmaz Sahebjam; David S Smookler; Rama Khokha; John S Mort
Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis.
The American journal of pathology 2005;166(6):1733-40.
2005: Fazilat F Mohammed; Caroline J Pennington; Zamaneh Kassiri; Jeffrey S Rubin; Paul D Soloway; Ulrich Ruther; Dylan R Edwards; Rama Khokha
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.
Hepatology (Baltimore, Md.) 2005;41(4):857-67.
2005: Tong Li; Limei Sun; Naomi Miller; Trudey Nicklee; Jennifer Woo; Lee Hulse-Smith; Ming Tsao; Rama Khokha; Lisa Martin; Norman F Boyd
The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(2):343-9.
2005: Zamaneh Kassiri; Rama Khokha
Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors.
Thrombosis and haemostasis 2005;93(2):212-9.
2004: Sefer Elezkurtaj; Charlotte Kopitz; Andrew H Baker; Alejandra Perez-Cantó; Matthias J E Arlt; Rama Khokha; Bernd Gansbacher; Martina Anton; Karsten Brand; Achim Krüger
Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.
The journal of gene medicine 2004;6(11):1228-37.
2004: Paul W M Fedak; David S Smookler; Zamaneh Kassiri; Nobuhisa Ohno; Kevin J Leco; Subodh Verma; Donald A G Mickle; Katrina L M Watson; Carlo V Hojilla; William Cruz; Richard D Weisel; Ren-Ke Li; Rama Khokha
TIMP-3 deficiency leads to dilated cardiomyopathy.
Circulation 2004;110(16):2401-9.
2004: Fazilat F Mohammed; David S Smookler; Suzanne E M Taylor; Barbara Fingleton; Zamaneh Kassiri; Otto H Sanchez; Jane L English; Lynn M Matrisian; Billie Au; Wen-Chen Yeh; Rama Khokha
Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
Nature genetics 2004;36(9):969-77.
2004: Yuan Kong; Raymond Poon; Puviindran Nadesan; Tamara Di Muccio; Riccardo Fodde; Rama Khokha; Benjamin A Alman
Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
Cancer research 2004;64(16):5795-803.
2004: John Peter McPherson; Bénédicte Lemmers; Richard Chahwan; Ashwin Pamidi; Eva Migon; Elzbieta Matysiak-Zablocki; Mary Ellen Moynahan; Jeroen Essers; Katsuhiro Hanada; Anuradha Poonepalli; Otto Sanchez-Sweatman; Rama Khokha; Roland Kanaar; Maria Jasin; M Prakash Hande; Raza Hakem
Involvement of mammalian Mus81 in genome integrity and tumor suppression.
Science (New York, N.Y.) 2004;304(5678):1822-6.
2004: John Peter McPherson; Bénédicte Lemmers; Atsushi Hirao; Anne Hakem; Jacinth Abraham; Eva Migon; Elzbieta Matysiak-Zablocki; Laura Tamblyn; Otto Sanchez-Sweatman; Rama Khokha; Jeremy Squire; M Prakash Hande; Tak W Mak; Raza Hakem
Collaboration of Brca1 and Chk2 in tumorigenesis.
Genes & development 2004;18(10):1144-53.
2004: Mehrdad Hariri; Geoffrey A Wood; Marco A DiGrappa; Michelle MacPherson; Stephanie A Backman; Martin J Yaffe; Tak W Mak; Norman F Boyd; Rama Khokha
Experimental manipulation of radiographic density in mouse mammary gland.
Breast cancer research : BCR 2004;6(5):R540-5.
2003: Roger A Moorehead; Carlo V Hojilla; Ian De Belle; Geoffrey A Wood; Jimmie E Fata; Eileen D Adamson; Katrina L M Watson; Dylan R Edwards; Rama Khokha
Insulin-like growth factor-II regulates PTEN expression in the mammary gland.
The Journal of biological chemistry 2003;278(50):50422-7.
2003: Carlo V Hojilla; Fazilat F Mohammed; Rama Khokha
Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development.
British journal of cancer 2003;89(10):1817-21.
2003: Rob Cairns; Rama Khokha; Richard P Hill
Molecular mechanisms of tumor invasion and metastasis: an integrated view.
Current molecular medicine 2003;3(7):659-71.
2003: Emily K Griffiths; Otto H Sanchez; Pleasantine Mill; Connie M Krawczyk; Carlo V Hojilla; Evelyn Rubin; Marion M Nau; Rama Khokha; Stan Lipkowitz; Chi-Chung Hui; Josef M Penninger
Cbl-3-deficient mice exhibit normal epithelial development.
Molecular and cellular biology 2003;23(21):7708-18.
2003: Fazilat F Mohammed; David S Smookler; Rama Khokha
Metalloproteinases, inflammation, and rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii43-7.
2003: Sean E Gill; M Cynthia Pape; Rama Khokha; Andrew J Watson; Kevin J Leco
A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis.
Developmental biology 2003;261(2):313-23.
2003: Susann Schenk; Edith Hintermann; Martin Bilban; Naohiko Koshikawa; Carlo V Hojilla; Rama Khokha; Vito Quaranta
Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution.
The Journal of cell biology 2003;161(1):197-209.
2003: Roger A Moorehead; Otto H Sanchez; R Mitchell Baldwin; Rama Khokha
Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma.
Oncogene 2003;22(6):853-7.
2002: Matthias J E Arlt; Charlotte Kopitz; Caroline Pennington; Katrina L M Watson; Hans-Willi Krell; Wolfram Bode; Bernd Gansbacher; Rama Khokha; Dylan R Edwards; Achim Krüger
Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.
Cancer research 2002;62(19):5543-50.
2001: AT Ho; EB Voura; Paul D Soloway; Katrina L M Watson; Rama Khokha
MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function.
The Journal of biological chemistry 2001;276(43):40215-24.
2001: Jimmie E Fata; Kevin J Leco; EB Voura; H Y Yu; P Waterhouse; G Murphy; Roger A Moorehead; Rama Khokha
Accelerated apoptosis in the Timp-3-deficient mammary gland.
The Journal of clinical investigation 2001;108(6):831-41.
2001: Kevin J Leco; P Waterhouse; Otto H Sanchez; K L Gowing; A R Poole; A Wakeham; Tak W Mak; Rama Khokha
Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).
The Journal of clinical investigation 2001;108(6):817-29.
2001: Jimmie E Fata; V Chaudhary; Rama Khokha
Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle.
Biology of reproduction 2001;65(3):680-8.
2001: Y P Guo; Lisa J Martin; Wedad M Hanna; D Banerjee; N Miller; Eve Fishell; Rama Khokha; Norman F Boyd
Growth factors and stromal matrix proteins associated with mammographic densities.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(3):243-8.
2001: Zhenyu Zhu; Otto Sanchez-Sweatman; Xiaojun Huang; Robert Wiltrout; Rama Khokha; Qun Zhao; Elieser Gorelik
Anoikis and metastatic potential of cloudman S91 melanoma cells.
Cancer research 2001;61(4):1707-16.
2001: Roger A Moorehead; Jimmie E Fata; M B Johnson; Rama Khokha
Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice.
Cell death and differentiation 2001;8(1):16-29.
2000: Jimmie E Fata; Young-Yun Kong; Joyce Li; Takehiko Sasaki; Junko Irie-Sasaki; Roger A Moorehead; R Elliott; Sheila Scully; EB Voura; David L Lacey; william boyle; Rama Khokha; Josef M Penninger
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
Cell 2000;103(1):41-50.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Y Horie; Kurt Bachmaier; Jimmie E Fata; M Li; Akira Suzuki; Denis Bouchard; Alexandra Ho; Mark Redston; Steven Gallinger; Rama Khokha; Tak W Mak; Phillip T Hawkins; Len Stephens; Stephen W Scherer; May Tsao; Josef M Penninger
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Jimmie E Fata; AT Ho; Kevin J Leco; Roger A Moorehead; Rama Khokha
Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors.
Cellular and molecular life sciences : CMLS 2000;57(1):77-95.
2000: T Ibrahim; Iona T Leong; Otto Sanchez-Sweatman; Rama Khokha; Jaro Sodek; Howard C Tenenbaum; Bernhard Ganss; Sela Cheifetz
Expression of bone sialoprotein and osteopontin in breast cancer bone metastases.
Clinical & experimental metastasis 2000;18(3):253-60.
1999: DC Martin; J L Fowlkes; B Babic; Rama Khokha
Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1.
The Journal of cell biology 1999;146(4):881-92.
1999: Jimmie E Fata; Kevin J Leco; Roger A Moorehead; DC Martin; Rama Khokha
Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development.
Developmental biology 1999;211(2):238-54.
1999: Michael Michael; B Babic; Rama Khokha; May Tsao; James Ho; Melania Pintilie; Kevin J Leco; D Chamberlain; Frances A Shepherd
Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(6):1802-8.
1999: DC Martin; Otto Sanchez-Sweatman; AT Ho; D S Inderdeo; Ming Tsao; Rama Khokha
Transgenic TIMP-1 inhibits simian virus 40 T antigen-induced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):225-34.
1998: D J van Meyel; Otto Sanchez-Sweatman; N Kerkvliet; L Stitt; David A Ramsay; Rama Khokha; A F Chambers; J G Cairncross
Genetic background influences timing, morphology and dissemination of lymphomas in p53-deficient mice.
International journal of oncology 1998;13(5):917-22.
1998: A Krüger; Otto Sanchez-Sweatman; DC Martin; Jimmie E Fata; AT Ho; F William Orr; U Rüther; Rama Khokha
Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line.
Oncogene 1998;16(18):2419-23.
1998: F Xu; Timothy M Carlos; M Li; Otto Sanchez-Sweatman; Rama Khokha; Elieser Gorelik
Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes.
Clinical & experimental metastasis 1998;16(4):358-70.
1998: A Krüger; V Schirrmacher; Rama Khokha
The bacterial lacZ gene: an important tool for metastasis research and evaluation of new cancer therapies.
Cancer metastasis reviews 1998;17(3):285-94.
1997: A Krüger; Jimmie E Fata; Rama Khokha
Altered tumor growth and metastasis of a T-cell lymphoma in Timp-1 transgenic mice.
Blood 1997;90(5):1993-2000.
1997: Kevin J Leco; S S Apte; G T Taniguchi; S P Hawkes; Rama Khokha; Gilbert A Schultz; Dylan R Edwards
Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues.
FEBS letters 1997;401(2-3):213-7.
1996: S Koop; EE Schmidt; Ian C MacDonald; Vincent L Morris; Rama Khokha; M Grattan; J Leone; Ann F Chambers; Alan C Groom
Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):11080-4.
1996: D S Inderdeo; Dylan R Edwards; V K M Han; Rama Khokha
Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse.
Biology of reproduction 1996;55(3):498-508.
1996: DC Martin; U Rüther; Otto Sanchez-Sweatman; F William Orr; Rama Khokha
Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice.
Oncogene 1996;13(3):569-76.
1995: Ann F Chambers; Ian C MacDonald; EE Schmidt; S Koop; Vincent L Morris; Rama Khokha; Alan C Groom
Steps in tumor metastasis: new concepts from intravital videomicroscopy.
Cancer metastasis reviews 1995;14(4):279-301.
1995: Vincent L Morris; EE Schmidt; S Koop; Ian C MacDonald; M Grattan; Rama Khokha; M A McLane; S Niewiarowski; Ann F Chambers; Alan C Groom
Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis.
Experimental cell research 1995;219(2):571-8.
1995: S Koop; Ian C MacDonald; K Luzzi; EE Schmidt; Vincent L Morris; M Grattan; Rama Khokha; Ann F Chambers; Alan C Groom
Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate.
Cancer research 1995;55(12):2520-3.
1995: Rama Khokha; DC Martin; Jimmie E Fata
Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors.
Cancer metastasis reviews 1995;14(2):97-111.
1994: S Koop; Rama Khokha; EE Schmidt; Ian C MacDonald; Vincent L Morris; Ann F Chambers; Alan C Groom
Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.
Cancer research 1994;54(17):4791-7.
1994: Kevin J Leco; Rama Khokha; N Pavloff; S P Hawkes; Dylan R Edwards
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.
The Journal of biological chemistry 1994;269(12):9352-60.
1994: Rama Khokha
Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1.
Journal of the National Cancer Institute 1994;86(4):299-304.
1994: M E Leibbrandt; Rama Khokha; James Koropatnick
Antisense down-regulation of metallothionein in a human monocytic cell line alters adherence, invasion, and the respiratory burst.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(1):17-25.
1994: Rama Khokha; P Waterhouse
The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction.
Journal of neuro-oncology 1994;18(2):123-7.
1993: P Waterhouse; D T Denhardt; Rama Khokha
Temporal expression of tissue inhibitors of metalloproteinases in mouse reproductive tissues during gestation.
Molecular reproduction and development 1993;35(3):219-26.
1992: Rama Khokha; M J Zimmer; Sylvia M Wilson; Ann F Chambers
Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo.
Clinical & experimental metastasis 1992;10(6):365-70.
1992: Rama Khokha; M J Zimmer; C H Graham; Peeyush K Lala; P Waterhouse
Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells.
Journal of the National Cancer Institute 1992;84(13):1017-22.
1992: D T Denhardt; Rama Khokha; S Yagel; C M Overall; R S Parhar
Oncogenic consequences of down-modulating TIMP expression in 3T3 cells with antisense RNA.
Matrix (Stuttgart, Germany). Supplement 1992;1():281-5.
1991: Rama Khokha; P Waterhouse; Peeyush K Lala; M Zimmer; D T Denhardt; R Khokka
Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm? [corrected].
Journal of cancer research and clinical oncology 1991;117(4):333-8.
1990: P Waterhouse; Rama Khokha; D T Denhardt
Modulation of translation by the 5' leader sequence of the mRNA encoding murine tissue inhibitor of metalloproteinases.
The Journal of biological chemistry 1990;265(10):5585-9.
1989: A M Connor; P Waterhouse; Rama Khokha; D T Denhardt
Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily.
Biochimica et biophysica acta 1989;1009(1):75-82.
1989: S Yagel; Rama Khokha; D T Denhardt; R S Kerbel; R S Parhar; Peeyush K Lala
Mechanisms of cellular invasiveness: a comparison of amnion invasion in vitro and metastatic behavior in vivo.
Journal of the National Cancer Institute 1989;81(10):768-75.
1989: Rama Khokha; P Waterhouse; S Yagel; Peeyush K Lala; C M Overall; G Norton; D T Denhardt
Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.
Science (New York, N.Y.) 1989;243(4893):947-50.
1989: Rama Khokha; D T Denhardt
Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion.
Invasion & metastasis 1989;9(6):391-405.
1987: Rama Khokha; D T Denhardt
On the use of anti-sense RNA: down-regulation of mRNA encoding a metalloproteinase inhibitor.
Anticancer research 1987;7(4A):653-60.